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1,016 results on '"Magnani, Jared W."'

101. Abstract 01: Association of Copayment Level and Glucagon-Like Peptide-1 Receptor Agonist and Sodium-Glucose Cotransporter 2 Inhibitor Adherence in Diabetes and Heart Failure

Author

Essien, Utibe R, primary, Singh, Balvindar, additional, Swabe, Gretchen, additional, Johnson, Amber E, additional, Eberly, Lauren, additional, Wadhera, Rishi, additional, Breathett, Khadijah, additional, Vaduganathan, Muthiah, additional, and Magnani, Jared W, additional

Published
2023
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104. Transforming Atrial Fibrillation Research to Integrate Social Determinants of Health

Author

Benjamin, Emelia J., primary, Thomas, Kevin L., additional, Go, Alan S., additional, Desvigne-Nickens, Patrice, additional, Albert, Christine M., additional, Alonso, Alvaro, additional, Chamberlain, Alanna M., additional, Essien, Utibe R., additional, Hernandez, Inmaculada, additional, Hills, Mellanie True, additional, Kershaw, Kiarri N., additional, Levy, Phillip D., additional, Magnani, Jared W., additional, Matlock, Daniel D., additional, O’Brien, Emily C., additional, Rodriguez, Carlos J., additional, Russo, Andrea M., additional, Soliman, Elsayed Z., additional, Cooper, Lawton S., additional, and Al-Khatib, Sana M., additional

Published
2023
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105. Association Between Electrocardiographic Age and Cardiovascular Events in Community Settings : The Framingham Heart Study

Author

Brant, Luisa C. C., Horta Ribeiro, Antônio, Pinto-Filho, Marcelo M., Kornej, Jelena, Preis, Sarah R., Fetterman, Jessica L., Eromosele, Oseiwe B., Magnani, Jared W., Murabito, Joanne M., Larson, Martin G., Benjamin, Emelia J., Ribeiro, Antonio L. P., Lin, Honghuang, Brant, Luisa C. C., Horta Ribeiro, Antônio, Pinto-Filho, Marcelo M., Kornej, Jelena, Preis, Sarah R., Fetterman, Jessica L., Eromosele, Oseiwe B., Magnani, Jared W., Murabito, Joanne M., Larson, Martin G., Benjamin, Emelia J., Ribeiro, Antonio L. P., and Lin, Honghuang

Abstract

BACKGROUND: Deep neural networks have been used to estimate age from ECGs, the electrocardiographic age (ECG-age), which predicts adverse outcomes. However, this prediction ability has been restricted to clinical settings or relatively short periods. We hypothesized that ECG-age is associated with death and cardiovascular outcomes in the long-standing community-based FHS (Framingham Heart Study). METHODS: We tested the association of ECG-age with chronological age in the FHS cohorts in ECGs from 1986 to 2021. We calculated the gap between chronological and ECG-age (& UDelta;age) and classified individuals as having normal, accelerated, or decelerated aging, if & UDelta;age was within, higher, or lower than the mean absolute error of the model, respectively. We assessed the associations of & UDelta;age, accelerated and decelerated aging with death or cardiovascular outcomes (atrial fibrillation, myocardial infarction, and heart failure) using Cox proportional hazards models adjusted for age, sex, and clinical factors. RESULTS:The study population included 9877 FHS participants (mean age, 55 & PLUSMN;13 years; 54.9% women) with 34 948 ECGs. ECG-age was correlated to chronological age (r=0.81; mean absolute error, 9 & PLUSMN;7 years). After 17 & PLUSMN;8 years of follow-up, every 10-year increase of & UDelta;age was associated with 18% increase in all-cause mortality (hazard ratio [HR], 1.18 [95% CI, 1.12-1.23]), 23% increase in atrial fibrillation risk (HR, 1.23 [95% CI, 1.17-1.29]), 14% increase in myocardial infarction risk (HR, 1.14 [95% CI, 1.05-1.23]), and 40% increase in heart failure risk (HR, 1.40 [95% CI, 1.30-1.52]), in multivariable models. In addition, accelerated aging was associated with a 28% increase in all-cause mortality (HR, 1.28 [95% CI, 1.14-1.45]), whereas decelerated aging was associated with a 16% decrease (HR, 0.84 [95% CI, 0.74-0.95]). CONCLUSIONS:ECG-age was highly correlated with chronological age in FHS. The dif

Published
2023
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110. Association of Race and Ethnicity With Oral Anticoagulation and Associated Outcomes in Patients With Atrial Fibrillation

Author

Essien, Utibe R., primary, Chiswell, Karen, additional, Kaltenbach, Lisa A., additional, Wang, Tracy Y., additional, Fonarow, Gregg C., additional, Thomas, Kevin L., additional, Turakhia, Mintu P., additional, Benjamin, Emelia J., additional, Rodriguez, Fatima, additional, Fang, Margaret C., additional, Magnani, Jared W., additional, Yancy, Clyde W., additional, and Piccini, Jonathan P., additional

Published
2022
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113. Association of Neighborhood Disadvantage and Anticoagulation for Patients with Atrial Fibrillation in the Veterans Health Administration: the REACH-AF Study

Author

McDermott, Annie, primary, Kim, Nadejda, additional, Hausmann, Leslie R.M., additional, Magnani, Jared W., additional, Good, Chester B., additional, Litam, Terrence M.A., additional, Mor, Maria K., additional, Omole, Toluwa D., additional, Gellad, Walid F., additional, Fine, Michael J., additional, and Essien, Utibe R., additional

Published
2022
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123. Relation of Household Income to Access and Adherence to Combination Sacubitril/Valsartan in Heart Failure: A Retrospective Analysis of Commercially Insured Patients

Author

Johnson, Amber E., primary, Swabe, Gretchen M., additional, Addison, Daniel, additional, Essien, Utibe R., additional, Breathett, Khadijah, additional, Brewer, LaPrincess C., additional, Mazimba, Sula, additional, Mohammed, Selma F., additional, and Magnani, Jared W., additional

Published
2022
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130. Abstract P108: Natural Language Processing Extracted Social And Behavioral Determinants Of Health And Newer Glucose-lowering Drug Initiation Among Real-world Patients With Type 2 Diabetes

Author

Guo, Jingchuan, primary, Wu, Yonghui, additional, Guo, Yi, additional, Chen, Aokun, additional, Yu, Zehao, additional, Yang, Xi, additional, Magnani, Jared W, additional, Hernandez, Inmaculada, additional, O'Neal, LaToya, additional, Shenkman, Elizabeth, additional, and Bian, Jiang, additional

Published
2022
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133. Abstract 003: Contextual- And Personal-level Social Determinants Of Health And Real-world Adoption Of Novel Treatments For Improving Cardiovascular Outcomes In Type 2 Diabetes

Author

Guo, Jingchuan, primary, Hu, Hui, additional, Zheng, Yi, additional, Guo, Yi, additional, Chen, Aokun, additional, Magnani, Jared W, additional, Hernandez, Inmaculada, additional, O'Neal, LaToya, additional, Shenkman, Elizabeth, additional, and Bian, Jiang, additional

Published
2022
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139. Care at the End of Life: A Novel Curriculum Module Implemented by Medical Students.

Author

Magnani, Jared W., Minor, Melissa A., and Aldrich, Jon Matthew

Abstract

Describes the development, implementation, and evaluation of a curriculum module on end-of-life care developed by medical students and implemented at Stanford University School of Medicine. The curriculum teaches students a protocol for communicating with patients when breaking bad news and discussing treatment options. (EV)

Published
2002

140. Incidence of VTE in Patients With OSA: A Cohort Study

Author

Genuardi, Michael V., Rathore, Aman, Ogilvie, Rachel P., DeSensi, Rebecca S., Borker, Priya V., Magnani, Jared W., and Patel, Sanjay R.

Subjects
Cohort Studies, Sleep Apnea, Obstructive, Risk Factors, Incidence, Sleep: Original Research, Humans, Female, Obesity, Venous Thromboembolism, Middle Aged, Hypoxia
Abstract

BACKGROUND: Previous studies suggesting that OSA may be an independent risk factor for VTE have been limited by reliance on administrative data and lack of adjustment for clinical variables, including obesity. RESEARCH QUESTION: Does OSA confer an independent risk of incident VTE among a large clinical cohort referred for sleep-disordered breathing evaluation? STUDY DESIGN AND METHODS: We analyzed the clinical outcomes of 31,309 patients undergoing overnight polysomnography within a large hospital system. We evaluated the association of OSA severity with incident VTE, using Cox proportional hazards modeling accounting for age, sex, BMI, and common comorbid conditions. RESULTS: Patients were of mean age 50.4 years, and 50.1% were female. There were 1,791 VTE events identified over a mean follow-up of 5.3 years. In age- and sex-adjusted analyses, each 10-event/h increase in the apnea-hypopnea index was associated with a 4% increase in incident VTE risk (hazard ratio [HR], 1.04; 95% CI, 1.02-1.06). After adjusting for BMI, this association disappeared (HR, 1.01; 95% CI, 0.99-1.03). In contrast, nocturnal hypoxemia had an independent association with incident VTE. Patients with > 50% sleep time spent with oxyhemoglobin saturation < 90% are at 48% increased VTE risk compared with those without nocturnal hypoxemia (HR, 1.48; 95% CI, 1.16-1.69). INTERPRETATION: In this large cohort, we found that patients with more severe OSA as measured by the apnea-hypopnea index are more likely to have incident VTE. Adjusted analyses suggest that this association is explained on the basis of confounding by obesity. However, severe nocturnal hypoxemia may be a mechanism by which OSA heightens VTE risk.

Published
2021

148. Abstract 9306: Association of Race and Ethnicity and Anticoagulation in Patients With Atrial Fibrillation Dually Enrolled in Va and Medicare: Effects of Medicare Part D on the Equity of Prescribing

Author

Essien, Utibe R, primary, Kim, Nadejda, additional, Magnani, Jared W, additional, Good, Chester, additional, Litam, Terrence, additional, Hausmann, Leslie, additional, Mor, Maria, additional, Gellad, Walid, additional, and Fine, Michael J, additional

Published
2021
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