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101. Negative prognostic impact of electrolyte disorders in patients hospitalized for Covid-19 in a large multicenter study

Author

Genovesi, S, Regolisti, G, Rebora, P, Occhino, G, Belli, M, Molon, G, Citerio, G, Beltrame, A, Maloberti, A, Generali, E, Giannattasio, C, Epis, O, Rossetti, C, Bellelli, G, De Nalda, A, Capua, I, Valsecchi, M, Genovesi, Simonetta, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Belli, Michele, Molon, Giulio, Citerio, Giuseppe, Beltrame, Anna, Maloberti, Alessandro, Generali, Elena, Giannattasio, Cristina, Epis, Oscar Massimiliano, Rossetti, Claudio, Bellelli, Giuseppe, De Nalda, Ana Lleo, Capua, Ilaria, Valsecchi, Maria Grazia, Genovesi, S, Regolisti, G, Rebora, P, Occhino, G, Belli, M, Molon, G, Citerio, G, Beltrame, A, Maloberti, A, Generali, E, Giannattasio, C, Epis, O, Rossetti, C, Bellelli, G, De Nalda, A, Capua, I, Valsecchi, M, Genovesi, Simonetta, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Belli, Michele, Molon, Giulio, Citerio, Giuseppe, Beltrame, Anna, Maloberti, Alessandro, Generali, Elena, Giannattasio, Cristina, Epis, Oscar Massimiliano, Rossetti, Claudio, Bellelli, Giuseppe, De Nalda, Ana Lleo, Capua, Ilaria, and Valsecchi, Maria Grazia

Abstract

Background: The prognostic impact of electrolyte disorders in hospitalized COVID-19 patients is unclear. Methods: The study included all adult patients hospitalized for COVID-19 in four hospitals in Northern Italy between January 2020 and May 2021 with at least one serum potassium and sodium measurement performed within 3 days since admission. Primary outcome was in-hospital death; secondary outcome was Intensive Care Unit (ICU) admission. A cause-specific Cox proportional-hazards regression model was used for investigating the association between potassium and sodium (as either categorical or continuous variables) and mortality or admission to ICU. Results: Analyses included 3,418 adult hospitalized COVID-19 patients. At multivariable analysis, both hyperkalemia (Hazard Ratio, [HR] 1.833, 95% Confidence Interval [CI] 1.371–2.450) and sK above the median (K 5.1 vs 4.1 mmol/L: HR 1.523, 95% CI 1.295–1.798), and hypernatremia (HR 2.313, 95%CI 1.772–3.018) and sNa above the median (Na 149 vs 139 mmol/L: HR 1.442, 95% CI 1.234–1.686), were associated with in-hospital death, whereas hypokalemia and hyponatremia were not. Hyponatremia was associated with increased hazard of ICU admission (HR 1.884, 95%CI 1.389–2.556). Conclusions: Electrolyte disorders detected at hospital admission may allow early identification of COVID-19 patients at increased risk of adverse outcomes.

Published
2023

102. Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values

Author

Casiglia, E, Tikhonoff, V, Virdis, A, Grassi, G, Angeli, F, Barbagallo, C, Bombelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, D'Elia, L, Desideri, G, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Maloberti, A, Masulli, M, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Casiglia, Edoardo, Tikhonoff, Valérie, Virdis, Agostino, Grassi, Guido, Angeli, Fabio, Barbagallo, Carlo M, Bombelli, Michele, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Dell'Oro, Raffaella, D'elia, Lanfranco, Desideri, Giovambattista, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Maloberti, Alessandro, Masulli, Maria, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, Borghi, Claudio, Casiglia, E, Tikhonoff, V, Virdis, A, Grassi, G, Angeli, F, Barbagallo, C, Bombelli, M, Cicero, A, Cirillo, M, Cirillo, P, Dell'Oro, R, D'Elia, L, Desideri, G, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Lippa, L, Mallamaci, F, Masi, S, Maloberti, A, Masulli, M, Mazza, A, Mengozzi, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Pontremoli, R, Quarti-Trevano, F, Rattazzi, M, Reboldi, G, Rivasi, G, Salvetti, M, Tocci, G, Ungar, A, Verdecchia, P, Viazzi, F, Volpe, M, Borghi, C, Casiglia, Edoardo, Tikhonoff, Valérie, Virdis, Agostino, Grassi, Guido, Angeli, Fabio, Barbagallo, Carlo M, Bombelli, Michele, Cicero, Arrigo F G, Cirillo, Massimo, Cirillo, Pietro, Dell'Oro, Raffaella, D'elia, Lanfranco, Desideri, Giovambattista, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Lippa, Luciano, Mallamaci, Francesca, Masi, Stefano, Maloberti, Alessandro, Masulli, Maria, Mazza, Alberto, Mengozzi, Alessandro, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Pontremoli, Roberto, Quarti-Trevano, Fosca, Rattazzi, Marcello, Reboldi, Gianpaolo, Rivasi, Giulia, Salvetti, Massimo, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Viazzi, Francesca, Volpe, Massimo, and Borghi, Claudio

Abstract

Objective:In the frame of the Uric Acid Right for Heart Health (URRAH) study, a nationwide multicenter study involving adult participants recruited on a regional community basis from all the territory of Italy under the patronage of the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension, we searched for the cut-off values of the ratio between serum uric acid (SUA) and serum creatinine (sCr) able to predict cardiovascular (CV) events.Methods:Among 20 724 participants followed-up for 126 ± 64 months, after detecting cut-off by the receiver operating characteristic curves, we calculated by Cox models adjusted for confounders having CV events as dependent variable the hazard ratio (HR) of SUA/sCr > cut-off. We also verified if the role of cut-off varied with increasing SUA/sCr.Results:A plausible prognostic cut-off of SUA/sCr was found and was the same in the whole database, in men and in women (>5.35). The HR of SUA/sCr > cut-off was 1.159 (95% confidence interval [CI] 1.092-1.131, P < 0.03) in all, 1.161 (95% CI 1.021-1.335, P < 0.02) in men, and 1.444 (95% CI 1.012-1.113, P < 0.03) in women. In increasing quintiles of SUA/sCr the cut-offs were >3.08, >4.87, >5.35, >6.22 and >7.58, respectively. The HRs significantly increased from the 3rd to the 5th quintile (1.21, 95% CI 1.032-1.467, P = 0.018; 1.294, 95% CI 1.101-1.521, P = 0.002; and 1.642, 95% CI 1.405-1.919, P < 0.0001; respectively), that is, over 5.35, whereas the 2nd quintile was not significantly different from the 1st (reference).Conclusion:Having SUA/sCr >5.35 is an independent CV risk indicator both in men and women. The cut-off is dynamic and significantly increases with increasing SUA/sCr.

Published
2023

103. The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation

Author

Maloberti, Alessandro; https://orcid.org/0000-0002-2612-6264, Mengozzi, Alessandro; https://orcid.org/0000-0003-2834-9725, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe; https://orcid.org/0000-0002-4367-3884, Angeli, Fabio; https://orcid.org/0000-0003-4925-7985, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria; https://orcid.org/0000-0002-4114-038X, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo; https://orcid.org/0000-0002-0003-3289, Cianci, Rosario, Ciccarelli, Michele; https://orcid.org/0000-0003-2379-1960, Cirillo, Massimo; https://orcid.org/0000-0002-6409-3504, Cirillo, Pietro, Desideri, Giovambattista; https://orcid.org/0000-0002-0145-1271, D'Elia, Lanfranco; https://orcid.org/0000-0002-1782-0211, Dell'Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto; https://orcid.org/0000-0002-4861-0911, Iaccarino, Guido, Lippa, Luciano; https://orcid.org/0000-0003-1249-3861, Mallamaci, Francesca, Masi, Stefano; https://orcid.org/0000-0002-7591-3686, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza; https://orcid.org/0000-0002-4007-9441, et al, Maloberti, Alessandro; https://orcid.org/0000-0002-2612-6264, Mengozzi, Alessandro; https://orcid.org/0000-0003-2834-9725, Russo, Elisa, Cicero, Arrigo Francesco Giuseppe; https://orcid.org/0000-0002-4367-3884, Angeli, Fabio; https://orcid.org/0000-0003-4925-7985, Agabiti Rosei, Enrico, Barbagallo, Carlo Maria; https://orcid.org/0000-0002-4114-038X, Bernardino, Bruno, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo; https://orcid.org/0000-0002-0003-3289, Cianci, Rosario, Ciccarelli, Michele; https://orcid.org/0000-0003-2379-1960, Cirillo, Massimo; https://orcid.org/0000-0002-6409-3504, Cirillo, Pietro, Desideri, Giovambattista; https://orcid.org/0000-0002-0145-1271, D'Elia, Lanfranco; https://orcid.org/0000-0002-1782-0211, Dell'Oro, Raffaella, Facchetti, Rita, Ferri, Claudio, Galletti, Ferruccio, Giannattasio, Cristina, Gesualdo, Loreto; https://orcid.org/0000-0002-4861-0911, Iaccarino, Guido, Lippa, Luciano; https://orcid.org/0000-0003-1249-3861, Mallamaci, Francesca, Masi, Stefano; https://orcid.org/0000-0002-7591-3686, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza; https://orcid.org/0000-0002-4007-9441, and et al

Abstract

The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.

Published
2023

104. Serum Uric Acid Predicts All-Cause and Cardiovascular Mortality Independently of Hypertriglyceridemia in Cardiometabolic Patients without Established CV Disease: A Sub-Analysis of the URic acid Right for heArt Health (URRAH) Study

Author

Mengozzi, Alessandro; https://orcid.org/0000-0003-2834-9725, Pugliese, Nicola Riccardo; https://orcid.org/0000-0002-5473-227X, Desideri, Giovambattista; https://orcid.org/0000-0002-0145-1271, Masi, Stefano; https://orcid.org/0000-0002-7591-3686, Angeli, Fabio; https://orcid.org/0000-0003-4925-7985, Barbagallo, Carlo Maria; https://orcid.org/0000-0002-4114-038X, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo; https://orcid.org/0000-0002-0003-3289, Cianci, Rosario, Ciccarelli, Michele; https://orcid.org/0000-0003-2379-1960, Cicero, Arrigo F G; https://orcid.org/0000-0002-4367-3884, Cirillo, Massimo; https://orcid.org/0000-0002-6409-3504, Cirillo, Pietro, Dell'Oro, Raffaella, D'Elia, Lanfranco; https://orcid.org/0000-0002-1782-0211, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto; https://orcid.org/0000-0002-4861-0911, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano; https://orcid.org/0000-0003-1249-3861, Mallamaci, Francesca, Maloberti, Alessandro; https://orcid.org/0000-0002-2612-6264, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza; https://orcid.org/0000-0002-4007-9441, Nazzaro, Pietro, Palatini, Paolo; https://orcid.org/0000-0001-5402-4946, et al, Mengozzi, Alessandro; https://orcid.org/0000-0003-2834-9725, Pugliese, Nicola Riccardo; https://orcid.org/0000-0002-5473-227X, Desideri, Giovambattista; https://orcid.org/0000-0002-0145-1271, Masi, Stefano; https://orcid.org/0000-0002-7591-3686, Angeli, Fabio; https://orcid.org/0000-0003-4925-7985, Barbagallo, Carlo Maria; https://orcid.org/0000-0002-4114-038X, Bombelli, Michele, Cappelli, Federica, Casiglia, Edoardo; https://orcid.org/0000-0002-0003-3289, Cianci, Rosario, Ciccarelli, Michele; https://orcid.org/0000-0003-2379-1960, Cicero, Arrigo F G; https://orcid.org/0000-0002-4367-3884, Cirillo, Massimo; https://orcid.org/0000-0002-6409-3504, Cirillo, Pietro, Dell'Oro, Raffaella, D'Elia, Lanfranco; https://orcid.org/0000-0002-1782-0211, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto; https://orcid.org/0000-0002-4861-0911, Giannattasio, Cristina, Grassi, Guido, Iaccarino, Guido, Lippa, Luciano; https://orcid.org/0000-0003-1249-3861, Mallamaci, Francesca, Maloberti, Alessandro; https://orcid.org/0000-0002-2612-6264, Masulli, Maria, Mazza, Alberto, Muiesan, Maria Lorenza; https://orcid.org/0000-0002-4007-9441, Nazzaro, Pietro, Palatini, Paolo; https://orcid.org/0000-0001-5402-4946, and et al

Abstract

High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in the presence of normal and high TG levels has never been investigated. We included 8124 patients from the URic acid Right for heArt Health (URRAH) study cohort who were followed for over 20 years and had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) and cardiovascular mortality (CVM) were explored by the Kaplan-Meier estimator and Cox multivariable regression, adopting recently defined SUA cut-offs for ACM (≥4.7 mg/dL) and CVM (≥5.6 mg/dL). Exploratory analysis across cardiometabolic subgroups and a sensitivity analysis using SUA/serum creatinine were performed as validation. SUA predicted ACM (HR 1.25 [1.12-1.40], p < 0.001) and CVM (1.31 [1.11-1.74], p < 0.001) in the whole study population, and according to TG strata: ACM in normotriglyceridemia (HR 1.26 [1.12-1.43], p < 0.001) and hypertriglyceridemia (1.31 [1.02-1.68], p = 0.033), and CVM in normotriglyceridemia (HR 1.46 [1.23-1.73], p < 0.001) and hypertriglyceridemia (HR 1.31 [0.99-1.64], p = 0.060). Exploratory and sensitivity analyses confirmed our findings, suggesting a substantial role of SUA in normotriglyceridemia and hypertriglyceridemia. In conclusion, we report that SUA can predict ACM and CVM in cardiometabolic patients without established cardiovascular disease, independent of TG levels.

Published
2023

105. Serum uric acid and left ventricular mass index independently predict cardiovascular mortality: The uric acid right for heart health (URRAH) project

Author

Muiesan, Maria Lorenza, Agabiti Rosei, Claudia, Paini, Anna, Casiglia, Edoardo, Cirillo, Massimo, Grassi, Guido, Iaccarino, Guido, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Mengozzi, Alessandro, Palatini, Paolo, Parati, Gianfranco, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Borghi, Claudio, Working Group on Uric Acid and Cardiovascular Risk of the Italia, Muiesan, Maria Lorenza, Agabiti Rosei, Claudia, Paini, Anna, Casiglia, Edoardo, Cirillo, Massimo, Grassi, Guido, Iaccarino, Guido, Mallamaci, Francesca, Maloberti, Alessandro, Mazza, Alberto, Mengozzi, Alessandro, Palatini, Paolo, Parati, Gianfranco, Reboldi, Gianpaolo, Rivasi, Giulia, Russo, Elisa, Salvetti, Massimo, Tikhonoff, Valerie, Tocci, Giuliano, Borghi, Claudio, and Working Group on Uric Acid and Cardiovascular Risk of the Italia

Abstract

UNLABELLED A relationship between serum uric acid (SUA) and cardiovascular (CV) events has been documented in the Uric Acid Right for Heart Health (URRAH) study. AIM of this study was to investigate the association between SUA and left ventricular mass index (LVMI) and whether SUA and LVMI or their combination may predict the incidence of CV death. METHODS Subjects with echocardiographic measurement of LVMI included in the URRAH study (n=10733) were part of this analysis. LV hypertrophy (LVH) was defined as LVMI > 95 g/m2 in women and 115 g/m2 in men. RESULTS A significant association between SUA and LVMI was observed in multiple regression analysis in men: beta 0,095, F 5.47, P< 0.001 and women: beta 0,069, F 4.36, P<0.001. During follow-up 319 CV deaths occurred. Kaplan-Meier curves showed a significantly poorer survival rate in subjects with higher SUA (> 5.6 mg/dl in men and 5.1 mg/dl in women) and LVH (log-rank chi-square 298.105; P<0.0001). At multivariate Cox regression analysis in women LVH alone and the combination of higher SUA and LVH but not hyperuricemia alone, were associated with a higher risk of CV death, while in men hyperuricemia without LVH, LVH without hyperuricemia and their combination were all associated with a higher incidence of CV death. CONCLUSIONS Our findings demonstrate that SUA is independently associated with LVMI and suggest that the combination of hyperuricemia with LVH is an independent and powerful predictor for CV death both in men and women.

Published
2023

107. Spring Meeting of the Young Researchers of SID, SIIA, SIMI, SIPREC, SISA

Author

Pavanello, Chiara, additional, Bianconi, Vanessa, additional, Da Dalt, Lorenzo, additional, Gallo, Giovanna, additional, Mancusi, Costantino, additional, Ciccarelli, Michele, additional, Maloberti, Alessandro, additional, Spannella, Francesco, additional, Fimiani, Fabio, additional, D’Ardes, Damiano, additional, Lombardi, Rosa, additional, Talerico, Giovanni, additional, and Cavallo, Massimiliano, additional

Published
2023
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109. Serum uric acid and left ventricular mass index independently predict cardiovascular mortality: The uric acid right for heart health (URRAH) project

Author

Muiesan, Maria Lorenza, primary, Agabiti Rosei, Claudia, additional, Paini, Anna, additional, Casiglia, Edoardo, additional, Cirillo, Massimo, additional, Grassi, Guido, additional, Iaccarino, Guido, additional, Mallamaci, Francesca, additional, Maloberti, Alessandro, additional, Mazza, Alberto, additional, Mengozzi, Alessandro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Russo, Elisa, additional, Salvetti, Massimo, additional, Tikhonoff, Valerie, additional, Tocci, Giuliano, additional, and Borghi, Claudio, additional

Published
2023
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113. Serum Uric Acid Predicts All-Cause and Cardiovascular Mortality Independently of Hypertriglyceridemia in Cardiometabolic Patients without Established CV Disease: A Sub-Analysis of the URic acid Right for heArt Health (URRAH) Study

Author

Mengozzi, Alessandro, primary, Pugliese, Nicola Riccardo, additional, Desideri, Giovambattista, additional, Masi, Stefano, additional, Angeli, Fabio, additional, Barbagallo, Carlo Maria, additional, Bombelli, Michele, additional, Cappelli, Federica, additional, Casiglia, Edoardo, additional, Cianci, Rosario, additional, Ciccarelli, Michele, additional, Cicero, Arrigo F. G., additional, Cirillo, Massimo, additional, Cirillo, Pietro, additional, Dell’Oro, Raffaella, additional, D’Elia, Lanfranco, additional, Ferri, Claudio, additional, Galletti, Ferruccio, additional, Gesualdo, Loreto, additional, Giannattasio, Cristina, additional, Grassi, Guido, additional, Iaccarino, Guido, additional, Lippa, Luciano, additional, Mallamaci, Francesca, additional, Maloberti, Alessandro, additional, Masulli, Maria, additional, Mazza, Alberto, additional, Muiesan, Maria Lorenza, additional, Nazzaro, Pietro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Pontremoli, Roberto, additional, Quarti-Trevano, Fosca, additional, Rattazzi, Marcello, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Russo, Elisa, additional, Salvetti, Massimo, additional, Tikhonoff, Valerie, additional, Tocci, Giuliano, additional, Ungar, Andrea, additional, Verdecchia, Paolo, additional, Viazzi, Francesca, additional, Volpe, Massimo, additional, Borghi, Claudio, additional, and Virdis, Agostino, additional

Published
2023
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114. The Key Role of a Psychoactive Substance Use History in Comprehensive Cardiovascular Risk Assessment, Diagnosis, Treatment, and Prevention

Author

Ciccirillo, Francesco, primary, Abrignani, Maurizio G., additional, Temporelli, Pier Luigi, additional, Binaghi, Giulio, additional, Cappelletto, Chiara, additional, Lopriore, Vincenzo, additional, Cesaro, Arturo, additional, Maloberti, Alessandro, additional, Cozzoli, Danilo, additional, Riccio, Carmine, additional, Caldarola, Pasquale, additional, Oliva, Fabrizio, additional, Gabrielli, Domenico, additional, and Colivicchi, Furio, additional

Published
2023
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116. Lipoprotein(a): Cardiovascular Disease, Aortic Stenosis and New Therapeutic Option

Author

Maloberti, Alessandro, primary, Fabbri, Saverio, additional, Colombo, Valentina, additional, Gualini, Elena, additional, Monticelli, Massimiliano, additional, Daus, Francesca, additional, Busti, Andrea, additional, Galasso, Michele, additional, De Censi, Lorenzo, additional, Algeri, Michela, additional, Merlini, Piera Angelica, additional, and Giannattasio, Cristina, additional

Published
2022
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117. 555 ADHERENCE AND PERSISTENCE OF PCSK9 INHIBITORS IN CLINICAL PRACTICE: THE REAL-WORLD ITALIAN EXPERIENCE (AT-TARGET-IT STUDY)

Author

Marzano, Federica, primary, Basile, Christian, additional, Paolillo, Stefania, additional, Cesaro, Arturo, additional, Buonocore, Davide, additional, Asile, Gaetano, additional, Abbate, Vincenza, additional, Vicidomini, Francesca, additional, Maria Spaccarotella, Carmen Anna, additional, Spirito, Giulio, additional, Maloberti, Alessandro, additional, Iannuzzo, Gabriella, additional, Ciccone, Marco Matteo, additional, D´alleva, Alberto, additional, Corleto, Antonella, additional, Brunetti, Natale Daniele, additional, Indolfi, Ciro, additional, Gargiulo, Paola, additional, and Perrone-filardi, Pasquale, additional

Published
2022
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118. 85 ATRIAL FIBRILLATION INCIDENCE IN SARS-COV-2 INFECTED PATIENTS: PREDICTORS AND RELATIONSHIP WITH IN-HOSPITAL MORTALITY

Author

Maloberti, Alessandro, primary, Giannattasio, Cristina, additional, Rebora, Paola, additional, Occhino, Giuseppe, additional, Ughi, Nicola, additional, Rizzo, Jacopo, additional, Fabbri, Saverio, additional, Leidi, Filippo, additional, Cartella, Iside, additional, Rossetti, Claudio, additional, Epis, Oscar Massimiliano, additional, Molon, Giulio, additional, Bonfanti, Paolo, additional, Valsecchi, Maria Grazia, additional, and Genovesi, Simonetta, additional

Published
2022
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120. Mycotic coronary aneurysms

Author

Buono, Andrea, Maloberti, Alessandro, Bossi, Irene M., Piccaluga, Emanuela, Piccalò, Giacomo, Oreglia, Jacopo A., Moreo, Antonella, Russo, Claudio F., Oliva, Fabrizio, and Giannattasio, Cristina

Published
2019
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122. Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values

Author

Casiglia, Edoardo, primary, Tikhonoff, Valérie, additional, Virdis, Agostino, additional, Grassi, Guido, additional, Angeli, Fabio, additional, Barbagallo, Carlo M., additional, Bombelli, Michele, additional, Cicero, Arrigo F.G., additional, Cirillo, Massimo, additional, Cirillo, Pietro, additional, Dell’Oro, Raffaella, additional, D’elia, Lanfranco, additional, Desideri, Giovambattista, additional, Ferri, Claudio, additional, Galletti, Ferruccio, additional, Gesualdo, Loreto, additional, Giannattasio, Cristina, additional, Iaccarino, Guido, additional, Lippa, Luciano, additional, Mallamaci, Francesca, additional, Masi, Stefano, additional, Maloberti, Alessandro, additional, Masulli, Maria, additional, Mazza, Alberto, additional, Mengozzi, Alessandro, additional, Muiesan, Maria Lorenza, additional, Nazzaro, Pietro, additional, Palatini, Paolo, additional, Parati, Gianfranco, additional, Pontremoli, Roberto, additional, Quarti-Trevano, Fosca, additional, Rattazzi, Marcello, additional, Reboldi, Gianpaolo, additional, Rivasi, Giulia, additional, Salvetti, Massimo, additional, Tocci, Giuliano, additional, Ungar, Andrea, additional, Verdecchia, Paolo, additional, Viazzi, Francesca, additional, Volpe, Massimo, additional, and Borghi, Claudio, additional

Published
2022
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123. CMV seroprevalence and coronary CMV-DNA detection in immunocompetent patients with heart diseases

Author

CENTO, Valeria, primary, COLAGROSSI, Luna, additional, BOSSI, Irene, additional, ARMENIA, Daniele, additional, NAVA, Alice, additional, PICCINELLI, Enrico, additional, MALOBERTI, Alessandro, additional, INGLESE, Elvira, additional, MATARAZZO, Elisa, additional, DI RUSCIO, Federica, additional, PABA, Pierpaolo, additional, MARCUCCILLI, Fabbio, additional, PERRONE, Marco, additional, CHIRICOLO, Gaetano, additional, ALTERI, Claudia, additional, SCAGLIONE, Francesco, additional, VISMARA, Chiara, additional, CAMPISI, Daniela A., additional, FANTI, Diana, additional, ROMEO, Francesco, additional, ANDREONI, Massimo, additional, OLIVA, Fabrizio, additional, CECCHERINI-SILBERSTEIN, Francesca, additional, GIANNATTASIO, Cristina, additional, and PERNO, Carlo F., additional

Published
2022
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124. Relationship Between 24-Hour Ambulatory Central Systolic Blood Pressure and Left Ventricular Mass: A Prospective Multicenter Study

Author

Weber, Thomas, Wassertheurer, Siegfried, Schmidt-Trucksäss, Arno, Rodilla, Enrique, Ablasser, Cornelia, Jankowski, Piotr, Lorenza Muiesan, Maria, Giannattasio, Cristina, Mang, Claudia, Wilkinson, Ian, Kellermair, Jörg, Hametner, Bernhard, Pascual, Jose Maria, Zweiker, Robert, Czarnecka, Danuta, Paini, Anna, Salvetti, Massimo, Maloberti, Alessandro, and McEniery, Carmel

Published
2017
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125. CMV seroprevalence and coronary CMV-DNA detection in immunocompetent patients with heart diseases.

Author

CENTO, Valeria, COLAGROSSI, Luna, BOSSI, Irene, ARMENIA, Daniele, NAVA, Alice, PICCINELLI, Enrico, MALOBERTI, Alessandro, INGLESE, Elvira, MATARAZZO, Elisa, RUSCIO, Federica DI, PABA, Pierpaolo, MARCUCCILLI, Fabbio, PERRONE, Marco, CHIRICOLO, Gaetano, ALTERI, Claudia, SCAGLIONE, Francesco, VISMARA, Chiara, CAMPISI, Daniela A., FANTI, Diana, and ROMEO, Francesco

Published
2023
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127. Effects of Renal Sympathetic Denervation on Arterial Stiffness and Blood Pressure Control in Resistant Hypertensive Patients: A Single Centre Prospective Study

Author

Baroni, Matteo, Nava, Stefano, Giupponi, Luca, Meani, Paolo, Panzeri, Francesco, Varrenti, Marisa, Maloberti, Alessandro, Soriano, Francesco, Agrati, Antonio Maria, Ferraro, Giovanni, Colombo, Fabrizio, Rampoldi, Antonio, Mancia, Giuseppe, Colombo, Paola, Klugmann, Silvio, and Giannattasio, Cristina

Published
2015
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129. P34 24-Hour Ambulatory Brachial Versus Aortic Systolic Blood Pressure: Relationship with Left Ventricular Mass Significantly Differs. Pooled Results from the International 24 Hour Aortic Blood Pressure Consortium (i24ABC)

Author

Wassertheurer, Siegfried, Protogerou, Athanase, Sharman, James, Sala, Enrique Rodilla, Jankowski, Piotr, Muiesan, Maria Lorenza, Giannattasio, Cristina, Hametner, Bernhard, Pascual, Jose Maria, Zweiker, Robert, Argyris, Antonio, Paini, Anna, Wilkinson, Ian, Czarnecka, Danuta, Salvetti, Massimo, Maloberti, Alessandro, McEniery, Carmel, Li, Yan, Nemcsik, Janos, Pucci, Giacomo, Ablasser, Cornelia, Blacher, Jacques, Valleé, Alexandre, de la Sierra, Alejandro, Zhang, Yi, Ji, Hongwei, McDonnell, Barry, Mota, Marco, Paiva, Annelise, Brandao, Andrea, and Weber, Thomas

Published
2019
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130. Endothelial Dysfunction in Patients with Advanced Heart Failure Treated with Levosimendan Periodic Infusion Compared with Optimal Medical Therapy: A Pilot Study

Author

Maloberti, Alessandro, primary, Sun, Jinwei, additional, Zannoni, Jessica, additional, Occhi, Lucia, additional, Bassi, Ilaria, additional, Fabbri, Saverio, additional, Colombo, Valentina, additional, Gualini, Elena, additional, Algeri, Michela, additional, Varrenti, Marisa, additional, Masciocco, Gabriella, additional, Perna, Enrico, additional, Oliva, Fabrizio, additional, Cipriani, Manlio, additional, Frigerio, Maria, additional, and Giannattasio, Cristina, additional

Published
2022
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131. Negative prognostic impact of electrolyte disorders in patients hospitalized for Covid-19 in a large multicenter study

Author

Genovesi, Simonetta, primary, Regolisti, Giuseppe, additional, Rebora, Paola, additional, Occhino, Giuseppe, additional, Belli, Michele, additional, Molon, Giulio, additional, Citerio, Giuseppe, additional, Beltrame, Anna, additional, Maloberti, Alessandro, additional, Generali, Elena, additional, Giannattasio, Cristina, additional, Epis, Oscar Massimiliano, additional, Rossetti, Claudio, additional, Bellelli, Giuseppe, additional, De Nalda, Ana Lleo, additional, Capua, Ilaria, additional, and Valsecchi, Maria Grazia, additional

Published
2022
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132. Incident Atrial Fibrillation and In-Hospital Mortality in SARS-CoV-2 Patients

Author

Maloberti, Alessandro, primary, Giannattasio, Cristina, additional, Rebora, Paola, additional, Occhino, Giuseppe, additional, Ughi, Nicola, additional, Biolcati, Marco, additional, Gualini, Elena, additional, Rizzi, Jacopo Giulio, additional, Algeri, Michela, additional, Giani, Valentina, additional, Rossetti, Claudio, additional, Epis, Oscar Massimiliano, additional, Molon, Giulio, additional, Beltrame, Anna, additional, Bonfanti, Paolo, additional, Valsecchi, Maria Grazia, additional, and Genovesi, Simonetta, additional

Published
2022
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134. ATRIAL FIBRILLATION INCIDENCE IN SARS-COV-2 INFECTED PATIENTS: PREDICTORS AND RELATIONSHIP WITH IN-HOSPITAL MORTALITY

Author

Maloberti, Alessandro, primary, Giannattasio, Cristina, additional, Rebora, Paola, additional, Occhino, Giuseppe, additional, Ughi, Nicola, additional, Rizzo, Jacopo, additional, Fabbri, Saverio, additional, Leidi, Filippo, additional, Cartella, Iside, additional, Algeri, Michela, additional, Scarpellini, Sara, additional, Rossetti, Claudio, additional, Epis, Oscar, additional, Molon, Giulio, additional, Bonfanti, Paolo, additional, Valsecchi, Maria Grazia, additional, and Genovesi, Simonetta, additional

Published
2022
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138. Nutraceuticals in Chronic Coronary Syndromes: Preclinical Data and Translational Experiences

Author

Cristina Giannattasio, Maloberti Alessandro, Martina Milani, Giovanni Tavecchia, Enzo Grasso, Iside Cartella, Jinwey Sun, Chiara Tognola, Tognola, C, Alessandro, M, Milani, M, Cartella, I, Tavecchia, G, Grasso, E, Sun, J, and Giannattasio, C

Subjects
0301 basic medicine, medicine.medical_specialty, Cardiac energetic, Ischemic myocardium, Cardiovascular risk factors, Ischemia-reperfusion injury, Chronic coronary syndrome, Chronic coronary syndromes, Myocardial Reperfusion Injury, Review Article, Cardiac energetics, Translational Research, Biomedical, 03 medical and health sciences, 0302 clinical medicine, Nutraceutical, Pharmacotherapy, Internal Medicine, Animals, Humans, Medicine, Acute Coronary Syndrome, Intensive care medicine, business.industry, Myocardium, Preclinical data, Treatment Outcome, 030104 developmental biology, Dietary Supplements, Energy Metabolism, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Abstract

Non-pharmacological treatments have always been considered important in the management of Chronic Coronary Syndromes. Nutraceuticals ("Nutrition" + "Pharmaceutical") could fall both under the definition of non-pharmacological treatment and pharmacological one or, probably more correctly, in the middle of these two kinds of therapies. However, the word “nutraceuticals” never appears in the latest guidelines on this issue. This is probably determined by the fact that evidences on this topic are scarce and most of the published articles are based on preclinical data while translational experiences are available only for some molecules. In this review we will focus on nutraceutical strategies that act on the ischemic myocardium itself and not only on the cardiovascular risk factors. As demonstrated by the important number of papers published in recent years, this is an evolving topic and evaluated substances principally act on two mechanisms (cardiac energetics and ischemia-reperfusion damage) that will be also reviewed. Electronic supplementary material The online version of this article (doi:10.1007/s40292-020-00416-8) contains supplementary material, which is available to authorized users.

Published
2020
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139. IMPORTANCE OF URIC ACID THRESHOLD IN ITS CORRELATION WITH METABOLIC SYNDROME

Author

Maloberti, A, Garofani, I, Fumagalli, S, Ciampi, C, Ossola, P, Carbonaro, M, Monticelli, M, Tavecchia, G, Bombelli, M, Giannattasio, C, Maloberti, Alessandro, Garofani, Ilaria, Fumagalli, Stefano, Ciampi, Claudio Mario, Ossola, Paolo, Carbonaro, Marco, Monticelli, Massimiliano, Tavecchia, Giovanni, Bombelli, Michele, Giannattasio, Cristina, Maloberti, A, Garofani, I, Fumagalli, S, Ciampi, C, Ossola, P, Carbonaro, M, Monticelli, M, Tavecchia, G, Bombelli, M, Giannattasio, C, Maloberti, Alessandro, Garofani, Ilaria, Fumagalli, Stefano, Ciampi, Claudio Mario, Ossola, Paolo, Carbonaro, Marco, Monticelli, Massimiliano, Tavecchia, Giovanni, Bombelli, Michele, and Giannattasio, Cristina

Published
2022

140. Twenty-Four-Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals

Author

Weber, Thomas Protogerou, Athanase D. Agharazii, Mohsen and Argyris, Antonis Aoun Bahous, Sola Banegas, Jose R. Binder, Ronald K. Blacher, Jacques Araujo Brandao, Andrea Cruz, Juan J. Danninger, Kathrin Giannatasio, Cristina Graciani, Auxiliadora Hametner, Bernhard Jankowski, Piotr Li, Yan and Maloberti, Alessandro Mayer, Christopher C. McDonnell, Barry J. and McEniery, Carmel M. Antonio Mota Gomes, Marco Machado Gomes, Annelise Lorenza Muiesan, Maria Nemcsik, Janos Paini, Anna and Rodilla, Enrique Schutte, Aletta E. Sfikakis, Petros P. and Terentes-Printzios, Dimitrios Vallee, Alexandre Vlachopoulos, Charalambos Ware, Lisa Wilkinson, Ian Zweiker, Robert and Sharman, James E. Wassertheurer, Siegfried Int Acad 24 Hour Ambulatory Arot and Weber, Thomas Protogerou, Athanase D. Agharazii, Mohsen and Argyris, Antonis Aoun Bahous, Sola Banegas, Jose R. Binder, Ronald K. Blacher, Jacques Araujo Brandao, Andrea Cruz, Juan J. Danninger, Kathrin Giannatasio, Cristina Graciani, Auxiliadora Hametner, Bernhard Jankowski, Piotr Li, Yan and Maloberti, Alessandro Mayer, Christopher C. McDonnell, Barry J. and McEniery, Carmel M. Antonio Mota Gomes, Marco Machado Gomes, Annelise Lorenza Muiesan, Maria Nemcsik, Janos Paini, Anna and Rodilla, Enrique Schutte, Aletta E. Sfikakis, Petros P. and Terentes-Printzios, Dimitrios Vallee, Alexandre Vlachopoulos, Charalambos Ware, Lisa Wilkinson, Ian Zweiker, Robert and Sharman, James E. Wassertheurer, Siegfried Int Acad 24 Hour Ambulatory Arot

Abstract

Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18-94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBP(MAP/DBPcal)), or bSBP/diastolic blood pressure (cSBP(SBP/DBPcal)), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBP(MAP/DBPcal) were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBP(SBP/DBPcal), respectively. We pragmatically propose as upper normal limit for 24-hour cSBP(MAP/DBPcal) 135 mm Hg and for 24-hour cSBP(SBP/DBPcal) 120 mm Hg. bSBP dipping (nighttime-daytime/daytime SBP) was -10.6 % in young participants and decreased with increasing age. Central SBPSBP/DBPcal dipping was less pronounced (-8.7% in young participants). In contrast, cSBP(MAP/DBPcal) dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation.

Published
2022

141. Incident Atrial Fibrillation and In-Hospital Mortality in SARS-CoV-2 Patients

Author

Maloberti, A, Giannattasio, C, Rebora, P, Occhino, G, Ughi, N, Biolcati, M, Gualini, E, Rizzi, J, Algeri, M, Giani, V, Rossetti, C, Epis, O, Molon, G, Beltrame, A, Bonfanti, P, Valsecchi, M, Genovesi, S, Maloberti, Alessandro, Giannattasio, Cristina, Rebora, Paola, Occhino, Giuseppe, Ughi, Nicola, Biolcati, Marco, Gualini, Elena, Rizzi, Jacopo Giulio, Algeri, Michela, Giani, Valentina, Rossetti, Claudio, Epis, Oscar Massimiliano, Molon, Giulio, Beltrame, Anna, Bonfanti, Paolo, Valsecchi, Maria Grazia, Genovesi, Simonetta, Maloberti, A, Giannattasio, C, Rebora, P, Occhino, G, Ughi, N, Biolcati, M, Gualini, E, Rizzi, J, Algeri, M, Giani, V, Rossetti, C, Epis, O, Molon, G, Beltrame, A, Bonfanti, P, Valsecchi, M, Genovesi, S, Maloberti, Alessandro, Giannattasio, Cristina, Rebora, Paola, Occhino, Giuseppe, Ughi, Nicola, Biolcati, Marco, Gualini, Elena, Rizzi, Jacopo Giulio, Algeri, Michela, Giani, Valentina, Rossetti, Claudio, Epis, Oscar Massimiliano, Molon, Giulio, Beltrame, Anna, Bonfanti, Paolo, Valsecchi, Maria Grazia, and Genovesi, Simonetta

Abstract

Background: Among the different cardiovascular (CV) manifestations of the coronavirus disease 2019 (COVID-19), arrhythmia and atrial fibrillation (AF) in particular have recently received special attention. The aims of our study were to estimate the incidence of AF in patients hospitalized for COVID-19, and to evaluate its role as a possible predictor of in-hospital all-cause mortality. (2) Methods: We enrolled 3435 people with SARS-CoV2 infection admitted to three hospitals in Northern Italy from February 2020 to May 2021. We collected data on their clinical history, laboratory tests, pharmacological treatment and intensive care unit (ICU) admission. Incident AF and all-cause in-hospital mortality were considered as outcomes. (3) Results: 145 (4.2%) patients developed AF during hospitalization, with a median time since admission of 3 days (I-III quartile: 0, 12). Patients with incident AF were admitted more frequently to the ICU (39.3 vs. 12.4%, p < 0.001), and more frequently died (37.2 vs. 16.9%, p < 0.001). In the Cox regression model, the significant determinants of incident AF were age (HR: 1.041; 95% CI: 1.022, 1.060 per year), a history of AF (HR: 2.720; 95% CI: 1.508, 4.907), lymphocyte count (HR: 0.584; 95% CI: 0.384, 0.888 per 103/µL), estimated glomerular filtration rate (eGFR, HR: 0.988; 95% CI: 0.980, 0.996 per mL/min) and ICU admission (HR: 5.311; 95% CI: 3.397, 8.302). Incident AF was a predictor of all-cause mortality (HR: 1.405; 95% CI: 1.027, 1.992) along with age (HR: 1.057; 95% CI: 1.047, 1.067), male gender (HR: 1.315; 95% CI: 1.064; 1.626), dementia (HR: 1.373; 95% CI: 1.045, 1.803), lower platelet (HR: 0.997; 95% CI: 0.996, 0.998 per 103/µL) and lymphocyte counts (HR: 0.843; 95% CI: 0.725, 0.982 per 103/µL), C-Reactive protein values (HR: 1.004; 95% CI: 1.003, 1.005 per mg/L), eGFR (HR: 0.990; 95% CI: 0.986, 0.994 per mL/min), and ICU admission (HR: 1.759; 95% CI: 1.292, 2.395). (4) Conclusions: Incident AF is a common complication in C

Published
2022

142. Prescriptive Appropriateness in Primary Cardiovascular Prevention: Data from Niguarda Hospital

Author

Maloberti, A, Ceruti, D, Gualini, E, Colombo, V, Giani, V, Milani, M, Sun, J, Alloni, M, Giannattasio, C, Maloberti, Alessandro, Ceruti, Davide, Gualini, Elena, Colombo, Valentina, Giani, Valentina, Milani, Martina, Sun, Jinwei, Alloni, Marta, Giannattasio, Cristina, Maloberti, A, Ceruti, D, Gualini, E, Colombo, V, Giani, V, Milani, M, Sun, J, Alloni, M, Giannattasio, C, Maloberti, Alessandro, Ceruti, Davide, Gualini, Elena, Colombo, Valentina, Giani, Valentina, Milani, Martina, Sun, Jinwei, Alloni, Marta, and Giannattasio, Cristina

Published
2022

143. Resting Heart Rate and Arterial Stiffness: a Longitudinal Prospective Study in a Population of Hypertensive Patients

Author

Maloberti, A, Fumagalli, S, Garofani, I, Ghidini, S, Ruzzenenti, G, Bombelli, M, Fabbri, S, Giannattasio, C, Maloberti, Alessandro, Fumagalli, Stefano, Garofani, Ilaria, Ghidini, Simone, Ruzzenenti, Giacomo, Bombelli, Michele, Fabbri, Saverio, Giannattasio, Cristina, Maloberti, A, Fumagalli, S, Garofani, I, Ghidini, S, Ruzzenenti, G, Bombelli, M, Fabbri, S, Giannattasio, C, Maloberti, Alessandro, Fumagalli, Stefano, Garofani, Ilaria, Ghidini, Simone, Ruzzenenti, Giacomo, Bombelli, Michele, Fabbri, Saverio, and Giannattasio, Cristina

Abstract

The role of resting Heart Rate on the progression of arterial stiffness has not yet been extensively evaluated. The aim of this study is to investigate the relationship between resting HR and baseline arterial stiffness (evaluated by cfPWV) as well as its progression in a population of hypertensive patients over a 3.7 years follow-up period.

Published
2022

144. Atrial Fibrillation Incidence in SARS-COV-2 Infected Patients: Predictors and Relationship with in-Hospital Mortality

Author

Maloberti, A, Giannattasio, C, Rebora, P, Occhino, G, Ughi, N, Rizzo, J, Fabbri, S, Leidi, F, Cartella, I, Algeri, M, Scarpellini, S, Rossetti, C, Epis, O, Molon, G, Bonfanti, P, Valsecchi, M, Genovesi, S, Maloberti, Alessandro, Giannattasio, Cristina, Rebora, Paola, Occhino, Giuseppe, Ughi, Nicola, Rizzo, Jacopo, Fabbri, Saverio, Leidi, Filippo, Cartella, Iside, Algeri, Michela, Scarpellini, Sara, Rossetti, Claudio, Epis, Oscar, Molon, Giulio, Bonfanti, Paolo, Valsecchi, Maria Grazia, Genovesi, Simonetta, Maloberti, A, Giannattasio, C, Rebora, P, Occhino, G, Ughi, N, Rizzo, J, Fabbri, S, Leidi, F, Cartella, I, Algeri, M, Scarpellini, S, Rossetti, C, Epis, O, Molon, G, Bonfanti, P, Valsecchi, M, Genovesi, S, Maloberti, Alessandro, Giannattasio, Cristina, Rebora, Paola, Occhino, Giuseppe, Ughi, Nicola, Rizzo, Jacopo, Fabbri, Saverio, Leidi, Filippo, Cartella, Iside, Algeri, Michela, Scarpellini, Sara, Rossetti, Claudio, Epis, Oscar, Molon, Giulio, Bonfanti, Paolo, Valsecchi, Maria Grazia, and Genovesi, Simonetta

Abstract

Among the different CardioVascular (CV) manifestation of the COronaVIrus-related Disease (COVID) particular attention has been paid to arrhythmia and particularly to Atrial fibrillation (AF). The aim of our study was to assess the incidence of AF episodes in patients ospitalisat for COVID and to evaluate its predictors and its relationship with in-hospital all-cause mortality.

Published
2022

145. Endothelial Dysfunction in Patients with Advanced Heart Failure Treated with Levosimendan Periodic Infusion Compared with Optimal Medical Therapy: A Pilot Study

Author

Maloberti, A, Sun, J, Zannoni, J, Occhi, L, Bassi, I, Fabbri, S, Colombo, V, Gualini, E, Algeri, M, Varrenti, M, Masciocco, G, Perna, E, Oliva, F, Cipriani, M, Frigerio, M, Giannattasio, C, Maloberti, Alessandro, Sun, Jinwei, Zannoni, Jessica, Occhi, Lucia, Bassi, Ilaria, Fabbri, Saverio, Colombo, Valentina, Gualini, Elena, Algeri, Michela, Varrenti, Marisa, Masciocco, Gabriella, Perna, Enrico, Oliva, Fabrizio, Cipriani, Manlio, Frigerio, Maria, Giannattasio, Cristina, Maloberti, A, Sun, J, Zannoni, J, Occhi, L, Bassi, I, Fabbri, S, Colombo, V, Gualini, E, Algeri, M, Varrenti, M, Masciocco, G, Perna, E, Oliva, F, Cipriani, M, Frigerio, M, Giannattasio, C, Maloberti, Alessandro, Sun, Jinwei, Zannoni, Jessica, Occhi, Lucia, Bassi, Ilaria, Fabbri, Saverio, Colombo, Valentina, Gualini, Elena, Algeri, Michela, Varrenti, Marisa, Masciocco, Gabriella, Perna, Enrico, Oliva, Fabrizio, Cipriani, Manlio, Frigerio, Maria, and Giannattasio, Cristina

Abstract

Endothelial dysfunction (ED) is frequently found in patients with heart failure (HF). Among several pharmacological agents reported to improve endothelial function, levosimendan seems to be a promising one, even though, to date, only two previously published studies have evaluated its effects on ED in these patients. The aim of our pilot study was to further investigate the role of periodic levosimendan infusion on endothelial function in patients affected by advanced HF. In this cross-sectional study, three different groups were enrolled: 20 patients with advanced HF treated with periodic levosimendan (LEVO), 20 patients with HF on optimal medical therapy (OMT), and 20 healthy subjects (control group). ED was evaluated through flow-mediated dilation (FMD) at the level of the brachial artery. The three groups presented similar ages with significant differences in gender distribution, systolic blood pressure, and chronic kidney disease (eGFR < 30 mL/min). In HF patients, ischaemic aetiology was more prevalent in the LEVO group than in the OMT group (60 vs. 40%, p < 0.001). The New York Heart Association (NYHA) functional class was worse in the LEVO group, as well as in NT-proBNP (5636.7 ± 6164.6 ng/dL and 1243.7 ± 1487.2 ng/dL, in the LEVO and OMT groups, respectively, p = 0.005). The FMD was significantly higher in the healthy control group compared to that of the OMT group (15.7 ± 6.4 vs. 9.1 ± 6.0%, p = 0.007) while it showed an intermediate value in LEVO patients (12.4 ± 7.1%) (ANOVA p = 0.010). In conclusion, levosimendan therapy seems to ameliorate endothelial dysfunction related to heart failure. Longitudinal studies in patients on periodic therapy are needed in order to confirm the long-term effects of levosimendan on ED.

Published
2022

146. Accuracy of home blood pressure measurement: the ACCURAPRESS study–a proposal of Young Investigator Group of the Italian Hypertension Society (Società Italiana dell’Ipertensione Arteriosa)

Author

Mancusi, C, Bisogni, V, Maloberti, A, Manzi, M, Visco, V, Biolcati, M, Giani, V, Spannella, F, Monticone, S, Saladini, F, Rivasi, G, Turrin, G, Pucci, G, Pengo, M, Bertacchini, F, Ferri, C, Grassi, G, Muiesan, M, Mancusi, Costantino, Bisogni, Valeria, Maloberti, Alessandro, Manzi, Maria Virginia, Visco, Valeria, Biolcati, Marco, Giani, Valentina, Spannella, Francesco, Monticone, Silvia, Saladini, Francesca, Rivasi, Giulia, Turrin, Giada, Pucci, Giacomo, Pengo, Martino, Bertacchini, Fabio, Ferri, Claudio, Grassi, Guido, Muiesan, Maria Lorenza, Mancusi, C, Bisogni, V, Maloberti, A, Manzi, M, Visco, V, Biolcati, M, Giani, V, Spannella, F, Monticone, S, Saladini, F, Rivasi, G, Turrin, G, Pucci, G, Pengo, M, Bertacchini, F, Ferri, C, Grassi, G, Muiesan, M, Mancusi, Costantino, Bisogni, Valeria, Maloberti, Alessandro, Manzi, Maria Virginia, Visco, Valeria, Biolcati, Marco, Giani, Valentina, Spannella, Francesco, Monticone, Silvia, Saladini, Francesca, Rivasi, Giulia, Turrin, Giada, Pucci, Giacomo, Pengo, Martino, Bertacchini, Fabio, Ferri, Claudio, Grassi, Guido, and Muiesan, Maria Lorenza

Abstract

Purpose: Home blood pressure monitoring (HBPM) might be considered a valid alternative to ambulatory blood pressure monitoring (ABPM) for both the diagnosis and management of hypertension. Correct information on how to perform HBPM are crucial for its reliability. The aim of the present survey was to assess if hypertensive patients followed current recommendation on how to correctly perform HBPM measurements. Materials and methods: The survey included 30 different items on how to perform the HBPM. It was developed by the ‘Young Investigators’ group of the Italian Society of Arterial Hypertension (SIIA) and it was administered during the office visit between May 2019 and December 2021. Results: A total of 643 hypertensive patients participated in the study. Main results show that, despite the rate of informed patients was relatively high (71% of the whole population), unacceptable number of patients did not follow indications on how to perform a correct HBPM. Patients who were informed on how to measure home BP had a significantly higher rate of correct position during measurement (78 vs. 22%, p < 0.01), avoidance of talking and moving during measurement (68 vs. 32%, p < 0.0001), and correct number and time interval between two measurements (85 vs. 15%, p < 0.001). More accurate measurements of home BP were associated with less prevalence of carotid plaque. Conclusions: Correct performance for HBPM is low among patients treated in Italian hypertension centers. These findings shed light on the importance of correct HBPM measurements for the detection of accurate BP values for the proper management of hypertensive patients.

Published
2022

147. Prevalence of hypertension mediated organ damage in subjects with high-normal blood pressure without known hypertension as well as cardiovascular and kidney disease

Author

Maloberti, A, Rebora, P, Occhino, G, Alloni, M, Musca, F, Belli, O, Spano, F, Santambrogio, G, Occhi, L, De Chiara, B, Casadei, F, Moreo, A, Valsecchi, M, Giannattasio, C, Maloberti, Alessandro, Rebora, Paola, Occhino, Giuseppe, Alloni, Marta, Musca, Francesco, Belli, Oriana, Spano, Francesca, Santambrogio, Gloria Maria, Occhi, Lucia, De Chiara, Benedetta, Casadei, Francesca, Moreo, Antonella, Valsecchi, Maria Grazia, Giannattasio, Cristina, Maloberti, A, Rebora, P, Occhino, G, Alloni, M, Musca, F, Belli, O, Spano, F, Santambrogio, G, Occhi, L, De Chiara, B, Casadei, F, Moreo, A, Valsecchi, M, Giannattasio, C, Maloberti, Alessandro, Rebora, Paola, Occhino, Giuseppe, Alloni, Marta, Musca, Francesco, Belli, Oriana, Spano, Francesca, Santambrogio, Gloria Maria, Occhi, Lucia, De Chiara, Benedetta, Casadei, Francesca, Moreo, Antonella, Valsecchi, Maria Grazia, and Giannattasio, Cristina

Abstract

Purpose of our study was to assess the prevalence of hypertension mediated organ damage (HMOD) in healthy subjects with high-normal Blood Pressure (BP) comparing them with subjects with BP values that are considered normal (<130/85 mmHg) or indicative of hypertension (≥140/90 mmHg). Seven hundred fifty-five otherwise healthy subjects were included. HMOD was evaluated as pulse wave velocity (PWV), left ventricular mass index (LVMI), and carotid intima-media thickness (IMT) and plaque. When subjects were classified according to BP levels we found that the high-normal BP group showed intermediate values of PWV and higher values of IMT. This corresponds to intermediate prevalence of arterial stiffness, while there were no differences for increased IMT or carotid plaque. No subjects showed left ventricular hypertrophy. At multivariable analysis, the odds of having arterial stiffness or carotid HMOD in the high-normal group resulted not different to the normal group. In conclusion, in our otherwise healthy population, high-normal BP values were not related to aortic, carotid or cardiac HMOD.

Published
2022

148. Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) Project

Author

Russo, E, Viazzi, F, Pontremoli, R, Barbagallo, C, Bombelli, M, Casiglia, E, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Leoncini, G, Mallamaci, F, Maloberti, A, Masi, S, Mengozzi, A, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Rattazzi, M, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Virdis, A, Volpe, M, Grassi, G, Borghi, C, Russo, Elisa, Viazzi, Francesca, Pontremoli, Roberto, Barbagallo, Carlo Maria, Bombelli, Michele, Casiglia, Edoardo, Cicero, Arrigo Francesco Giuseppe, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Leoncini, Giovanna, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mengozzi, Alessandro, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valérie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Virdis, Agostino, Volpe, Massimo, Grassi, Guido, Borghi, Claudio, Russo, E, Viazzi, F, Pontremoli, R, Barbagallo, C, Bombelli, M, Casiglia, E, Cicero, A, Cirillo, M, Cirillo, P, Desideri, G, D'Elia, L, Ferri, C, Galletti, F, Gesualdo, L, Giannattasio, C, Iaccarino, G, Leoncini, G, Mallamaci, F, Maloberti, A, Masi, S, Mengozzi, A, Mazza, A, Muiesan, M, Nazzaro, P, Palatini, P, Parati, G, Rattazzi, M, Rivasi, G, Salvetti, M, Tikhonoff, V, Tocci, G, Ungar, A, Verdecchia, P, Virdis, A, Volpe, M, Grassi, G, Borghi, C, Russo, Elisa, Viazzi, Francesca, Pontremoli, Roberto, Barbagallo, Carlo Maria, Bombelli, Michele, Casiglia, Edoardo, Cicero, Arrigo Francesco Giuseppe, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D'Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Leoncini, Giovanna, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mengozzi, Alessandro, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valérie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Virdis, Agostino, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio

Abstract

Background: Hyperuricemia is commonly observed in patients with chronic kidney disease (CKD). However, a better understanding of the relationship among uric acid (UA) values, glomerular filtration rate (GFR) and albuminuria may shed light on the mechanisms underlying the excess of cardiovascular mortality associated with both chronic kidney disease and hyperuricemia and lead to better risk stratification. Our main goal was to study the relationships between serum uric acid and kidney disease measures (namely estimated GFR [eGFR] and albuminuria) in a large cohort of individuals at cardiovascular risk from the URic acid Right for heArt Health (URRAH) Project database. Methods: Clinical data of 26,971 individuals were analyzed. Factors associated with the presence of hyperuricemia defined on the basis of previously determined URRAH cutoffs for cardiovascular and all-cause mortality were evaluated through multivariate analysis. Chronic kidney disease was defined as eGFR < 60 ml/min per 1.73 m2 and/or abnormal urinary albumin excretion diagnosed as: (i) microalbuminuria if urinary albumin concentration was > 30 and ≤ 300 mg/L, or if urinary albumin-to-creatinine ratio (ACR) was > 3.4 mg/mmol and ≤ 34 mg/mmol; (ii) macroalbuminuria if urinary albumin concentration was > 300 mg/L, or if ACR was > 34 mg/mmol. Results: Mean age was 58 ± 15 years (51% males, 62% with hypertension and 12% with diabetes), mean eGFR was 81 ml/min per 1.73m22with a prevalence of eGFR < 60 and micro- or macroalbuminuria of 16, 15 and 4%, respectively. Serum uric acid showed a trend towards higher values along with decreasing renal function. Both the prevalence of gout and the frequency of allopurinol use increased significantly with the reduction of eGFR and the increase in albuminuria. Hyperuricemia was independently related to male gender, eGFR strata, and signs of insulin resistance such as body mass index (BMI) and triglycerides. Conclusions: The lower the eGFR the higher th

Published
2022

149. High heart rate amplifies the risk of cardiovascular mortality associated with elevated uric acid

Author

Palatini, P, Parati, G, Virdis, A, Reboldi, G, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Verdecchia, P, Angeli, F, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Georgiopoulos, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Palatini, Paolo, Parati, Gianfranco, Virdis, Agostino, Reboldi, Gianpaolo, Masi, Stefano, Mengozzi, Alessandro, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo M, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Verdecchia, Paolo, Angeli, Fabio, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Georgiopoulos, Georgios, Iaccarino, Guido, Nazzaro, Pietro, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, Borghi, Claudio, Palatini, P, Parati, G, Virdis, A, Reboldi, G, Masi, S, Mengozzi, A, Casiglia, E, Tikhonoff, V, Cicero, A, Ungar, A, Rivasi, G, Salvetti, M, Barbagallo, C, Bombelli, M, Dell'Oro, R, Bruno, B, Lippa, L, D'Elia, L, Verdecchia, P, Angeli, F, Mallamaci, F, Cirillo, M, Rattazzi, M, Cirillo, P, Gesualdo, L, Mazza, A, Giannattasio, C, Maloberti, A, Volpe, M, Tocci, G, Georgiopoulos, G, Iaccarino, G, Nazzaro, P, Galletti, F, Ferri, C, Desideri, G, Viazzi, F, Pontremoli, R, Muiesan, M, Grassi, G, Borghi, C, Palatini, Paolo, Parati, Gianfranco, Virdis, Agostino, Reboldi, Gianpaolo, Masi, Stefano, Mengozzi, Alessandro, Casiglia, Edoardo, Tikhonoff, Valerie, Cicero, Arrigo F G, Ungar, Andrea, Rivasi, Giulia, Salvetti, Massimo, Barbagallo, Carlo M, Bombelli, Michele, Dell'Oro, Raffaella, Bruno, Berardino, Lippa, Luciano, D'Elia, Lanfranco, Verdecchia, Paolo, Angeli, Fabio, Mallamaci, Francesca, Cirillo, Massimo, Rattazzi, Marcello, Cirillo, Pietro, Gesualdo, Loreto, Mazza, Alberto, Giannattasio, Cristina, Maloberti, Alessandro, Volpe, Massimo, Tocci, Giuliano, Georgiopoulos, Georgios, Iaccarino, Guido, Nazzaro, Pietro, Galletti, Ferruccio, Ferri, Claudio, Desideri, Giovambattista, Viazzi, Francesca, Pontremoli, Roberto, Muiesan, Maria Lorenza, Grassi, Guido, and Borghi, Claudio

Abstract

Aims: Whether the association between uric acid (UA) and cardiovascular disease is influenced by some facilitating factors is unclear. The aim of this study was to investigate whether the risk of cardiovascular mortality (CVM) associated with elevated UA was modulated by the level of resting heart rate (HR). Methods and results: Multivariable Cox analyses were made in 19 128 participants from the multicentre Uric acid Right for heArt Health study. During a median follow-up of 11.2 years, there were 1381 cases of CVM. In multivariable Cox models both UA and HR, either considered as continuous or categorical variables were independent predictors of CVM both improving risk discrimination (P ≤ 0.003) and reclassification (P < 0.0001) over a multivariable model. However, the risk of CVM related to high UA (≥5.5 mg/dL, top tertile) was much lower in the subjects with HR

Published
2022

150. Biochemical but not imaging parameters are predictive of outcome in septic shock: a pilot study

Author

Belli, O, Campolo, J, Vallerio, P, Musca, F, Moreo, A, Maloberti, A, Parolini, M, Bonacchini, L, Monti, G, De Gasperi, A, Fumagalli, R, Giannattasio, C, Belli, Oriana E, Campolo, Jonica, Vallerio, Paola, Musca, Francesco, Moreo, Antonella, Maloberti, Alessandro, Parolini, Marina, Bonacchini, Luca, Monti, Gianpaola, De Gasperi, Andrea, Fumagalli, Roberto, Giannattasio, Cristina, Belli, O, Campolo, J, Vallerio, P, Musca, F, Moreo, A, Maloberti, A, Parolini, M, Bonacchini, L, Monti, G, De Gasperi, A, Fumagalli, R, Giannattasio, C, Belli, Oriana E, Campolo, Jonica, Vallerio, Paola, Musca, Francesco, Moreo, Antonella, Maloberti, Alessandro, Parolini, Marina, Bonacchini, Luca, Monti, Gianpaola, De Gasperi, Andrea, Fumagalli, Roberto, and Giannattasio, Cristina

Abstract

Background: Septic shock is a severe form of sepsis marked by hypotension with an ominous outcome despite the introduction of modern intensive care. The aim of the present study is to obtain a panel with biomarkers, echocardiographic and vascular parameters to better risk stratify patients and identify those at higher risk of ominous outcome. Methods: Between May 2013 and April 2016, 35 consecutive patients admitted at the Intensive Care Unit (ICU) of ASST Great Metropolitan Hospital Niguarda with the diagnosis of severe sepsis or septic shock were enrolled. All patients underwent rest echocardiography and several circulating biomarkers of myocardial damage or oxidative stress. Results: The multivariate Cox’s proportional hazard model showed that the only independent prognostic predictor for 30-day mortality was the angiopoietin-2, (HR 1.017, 95% CI 1.000–1.034; P = 0.049). An angiopoietin-2 concentrations ≥ of 33,418 pg/mL was identified as the optimal threshold for the discrimination between survivors and non survivors at the time of admission in ICU, with a sensitivity of 80% and a specificity of 68%. Conclusions: Septic shock has a poor in-hospital outcome even when the best of care is implemented. Among the biochemical parameters angiopoietin was able to identify patients at risk of death. The lowest the value at admission, the highest the risk of in-hospital death. No echocardiographic nor vascular parameter was able to predict outcome in this setting.

Published
2022

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