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102. THE NRMP: ALL-IN...AND TESTING THE SOAPY WATERS?

Author

Mazzone, M., primary, Wieschhaus, M., additional, Abercrombie, S., additional, Chacko, S., additional, Gravel, J., additional, Hall, K., additional, Hoekzema, G., additional, Maxwell, L., additional, Shaffer, T., additional, and Tuggy, M., additional

Published
2012
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104. A FAMILY MEDICINE RESIDENCY PROGRAM CURRICULUM RESOURCE

Author

Tuggy, M., primary, Abercrombie, S., additional, Chacko, S., additional, Gravel, J., additional, Hall, K., additional, Hoekzema, G., additional, Maxwell, L., additional, Mazzone, M., additional, Shaffer, T., additional, and Wieschhaus, M., additional

Published
2012
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106. IMPLICATIONS OF THE 2011 ACGME DUTY HOUR RULES

Author

Gravel, J., primary, Abercrombie, S., additional, Chacko, S., additional, Hall, K., additional, Hoekzema, G., additional, Maxwell, L., additional, Mazzone, M., additional, Shaffer, T., additional, Tuggy, M., additional, and Wieschhaus, M., additional

Published
2011
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107. THE DELTA-EXCHANGE

Author

Mazzone, M., primary, Abercrombie, S., additional, Gravel, J., additional, Hall, K., additional, Hoekzema, G., additional, Kozakowski, S., additional, Schneider, B., additional, Shaffer, T., additional, and Wieschhaus, M., additional

Published
2011
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110. Sharpen the Saw!

Author

Hoekzema, G., primary, Wieschhaus, M., additional, Abercrombie, S., additional, Gravel, J. W., additional, Hall, K. L., additional, Kozakowski, S., additional, Mazzone, M. F., additional, Schneider, B. N., additional, and Shaffer, T., additional

Published
2011
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112. AFMRD STRATEGIC PLAN: PROGRESS IN GOVERNANCE

Author

Hall, K., primary, Carr, S., additional, Abercrombie, S., additional, Gravel, J. W., additional, Hoekzema, G., additional, Kozakowski, S., additional, Mazzone, M. F., additional, Schneider, B. N., additional, Shaffer, T., additional, and Wieschhaus, M., additional

Published
2010
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114. THE FAMILY MEDICINE MATCH: BULL MARKET OR DEAD CAT BOUNCE?

Author

Gravel, J., primary, Hall, K. L., additional, Abercrombie, S., additional, Carr, S., additional, Hoekzema, G., additional, Kozakowksi, S., additional, Lindsay, D., additional, Mazzone, M. F., additional, Shaffer, T. D., additional, and Wieshhaus, M., additional

Published
2010
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126. Significantly Improved Survival Time in Pigs with Complete Liver Ischemia Treated with a Novel Bioartificial Liver

Author

Flendrig, L.M., primary, Calise, F., additional, Di Florio, E., additional, Mancini, A., additional, Ceriello, A., additional, Santaniello, W., additional, Mezza, E., additional, Sicoli, F., additional, Belleza, G., additional, Bracco, A., additional, Cozzolino, S., additional, Scala, D., additional, Mazzone, M., additional, Fattore, M., additional, Gonzales, E., additional, and Chamuleau, R.A.F.M., additional

Published
1999
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129. Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way.

Author

Carmeliet P, De Smet F, Loges S, Mazzone M, Carmeliet, Peter, De Smet, Frederik, Loges, Sonja, and Mazzone, Massimiliano

Abstract

From the original concepts that tumors require a vascular supply to grow and that blocking angiogenesis could suppress tumor growth, the oncology field has witnessed clinical successes of VEGF-targeted antiangiogenic medicine. The field is now facing the challenge of overcoming resistance to VEGF-targeted therapy, and therefore additional angiogenesis inhibitors are being developed. Studies on how endothelial 'tip, stalk and phalanx cells' form sprouts have identified promising candidate targets with complementary mechanisms to VEGF. This Review provides a conceptual framework in which molecular discoveries and principles are discussed in light of clinical opportunities to develop new antiangiogenic agents. [ABSTRACT FROM AUTHOR]

Published
2009
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130. Design of new reaction conditions for characterization of a mutant thermophilic α-l-fucosidase.

Author

Cobucci-Ponzano, B., Conte, F., Mazzone, M., Bedini, E., Corsaro, M. M., Rossi, M., and Moracci, M.

Subjects
GLYCOSIDASES, GLYCOSIDES, CARBOHYDRATES, OLIGOSACCHARIDES, ENZYMES, CATALYSTS
Abstract

Glycosynthases are mutant glycosidases, which in the presence of activated glycosides and suitable reaction conditions, synthesize oligosaccharides without hydrolysing them. This feature makes these catalysts promising tools for the large scale synthesis of carbohydrates. However, despite the popularity of the glycosynthetic approach, the number of enzymes effecting glycosynthetic reactions is still limited. We report here on the design of novel reaction conditions for a thermophilic α-l-fucosidase mutant, which might provide a route for the production of novel glycosynthases. [ABSTRACT FROM AUTHOR]

Published
2008
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131. The use of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema.

Author

Ursella, S., Mazzone, M., Portale, G., Conti, G., Antonelli, M., and Silveri, N. Gentiloni

Abstract

The patient with acute heart failure may present with acute cardiogenic pulmonary edema (ACPE), a condition accompanied by severe respiratory distress, with crackles over the lung and orthopnea, and an O2 saturation usually < 90% on room air, prior to treatment. Non-invasive ventilation is the delivery of assisted ventilation without the need for endotracheal intubation and an invasive artificial airway. Two techniques are used for ventilatory support: continuous positive airway pressure (CPAP) and non-invasive positive-pressure ventilation (NPPV). There is a strong consensus that one of these two techniques should be used before endotracheal intubation and mechanical ventilation because non-invasive techniques dramatically reduce the need for mechanical ventilation via endotracheal intubation and its complications. The aim of this review is to evaluate and resume the evidence for the use of non-invasive positive pressure ventilation in the treatment of acute cardiogenic pulmonary edema according recent literature in order to guide physicians in using CPAP and NPPV in patients affected by ACPE in clinical practice. Recent literature showed that CPAP and NPPV both significantly decrease the need for endotracheal intubation, and CPAP significantly decreases mortality when compared to standard medical treatment. These techniques resulted safe and there is no evidence of increased risk of acute myocardial infarction (AMI) with either of them. Although both CPAP and NPPV present similar efficacy, CPAP has been shown to be cheaper and easier to implement in clinical practice and it could be considered the preferred intervention in patients with ACPE especially in the Emergency Department setting. [ABSTRACT FROM AUTHOR]

Published
2007

135. Raman study of fluorine effects on silica with embedded SnO2 nanoparticles

Author

Magni, E., Mazzone, M., Pegolotti, G., Lauria, A., Lorenzi, R., Chiodini, N., and Paleari, A.

Subjects
*SILICA, *FLUORINATION, *STANNIC oxide, *NANOPARTICLES, *GELATION, *CERAMIC materials, *RAMAN spectroscopy
Abstract

Abstract: Silica samples with embedded SnO2 nanoparticles have been produced by sol–gel method with a synthesis modified by the introduction of fluorinated silicon precursors. The structural features of silica network and SnO2 nanophase have been mapped inside the samples by means of confocal micro-Raman scattering spectroscopy. The results show that the detection of residual fluorine into the matrix as Si–F groups is accompanied by network dehydration, by intensity depletion of the D2 peak assigned to three-member rings of coordinated tetrahedra, and by SnO2 nanoparticles with much larger sizes than in fluorine-free material. [Copyright &y& Elsevier]

Published
2009
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136. Dilatative myocardiopathy and hemorheologic assessment

Author

Mazzone, M., Forte, P., Portale, G., Buccelletti, F., Ursella, S., La Sala, M., Testa, A., Marcello Covino, Pignataro, G., Ierardi, C., Bellocci, F., Biasucci, L., Rebuzzi, A., and Gentiloni Silveri, N.

144. Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism

Author

Thompson, AAR, Dickinson, RS, Murphy, F, Thomson, JP, Marriott, HM, Tavares, A, Willson, J, Williams, L, Lewis, A, Mirchandani, A, Dos Santos Coelho, P, Doherty, C, Ryan, E, Watts, E, Morton, NM, Forbes, S, Stimson, RH, Hameed, AG, Arnold, N, Preston, JA, Lawrie, A, Finisguerra, V, Mazzone, M, Sadiku, P, Goveia, J, Taverna, F, Carmeliet, P, Foster, SJ, Chilvers, ER, Cowburn, AS, Dockrell, DH, Johnson, RS, Meehan, RR, Whyte, MKB, and Walmsley

Subjects
Basic Science, 1108 Medical Microbiology, 2.1 Biological and endogenous factors, Infection, 3. Good health
Abstract

Hypoxia and bacterial infection frequently co-exist, in both acute and chronic clinical settings, and typically result in adverse clinical outcomes. To ameliorate this morbidity, we investigated the interaction between hypoxia and the host response. In the context of acute hypoxia, both S. aureus and S. pneumoniae infections rapidly induced progressive neutrophil mediated morbidity and mortality, with associated hypothermia and cardiovascular compromise. Preconditioning animals through longer exposures to hypoxia, prior to infection, prevented these pathophysiological responses and profoundly dampened the transcriptome of circulating leukocytes. Specifically, perturbation of HIF pathway and glycolysis genes by hypoxic preconditioning was associated with reduced leukocyte glucose utilisation, resulting in systemic rescue from a global negative energy state and myocardial protection. Thus we demonstrate that hypoxia preconditions the innate immune response and determines survival outcomes following bacterial infection through suppression of HIF-1α and neutrophil metabolism. The therapeutic implications of this work are that in the context of systemic or tissue hypoxia therapies that target the host response could improve infection associated morbidity and mortality.

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