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1,141 results on '"McCORMICK, RICHARD"'

101. Enhanced transforming growth factor-[beta] signaling and fibrogenesis in ovine fetal skeletal muscle of obese dams at late gestation

Author

Huang, Yan, Yan, Xu, Zhu, Mei J., McCormick, Richard J., Ford, Stephen P., Nathanielsz, Peter W., and Du, Min

Subjects
Pregnancy -- Diagnosis, Collagen -- Properties, Obesity -- Diagnosis, Transforming growth factors -- Properties, Cellular signal transduction -- Observations, Fibrosis -- Diagnosis, Muscles -- Medical examination, Biological sciences
Abstract

Maternal obesity (MO) is increasing at an alarming rate. The objective of this study was to evaluate the effect of MO on fibrogenesis in fetal skeletal muscle during maturation in late gestation. Nonpregnant ewes were assigned to a control diet (Con; fed 100% of NRC nutrient recommendations, n = 6) or obesogenic diet (OB; fed 150% of NRC recommendations, n = 6) from 60 days before conception, and fetal semitendenosus (St) muscle was sampled at 135 days of gestation (term 148 days). Total concentration and area of collagen in cross-sections of muscle increased by 27.0 [+ or -] 6.0 (P < 0.05) and 105.1 [+ or -] 5.9% (P = 0.05) in OB compared with Con fetuses. The expression of precursor TGF-[beta] was 177.3 [+ or -] 47.6% higher, and concentration of phospho-p38 74.7 [+ or -] 23.6% was higher (P < 0.05) in OB than in CON fetal muscle. Increases of 327.9 [+ or -] 168.0 (P < 0.05) and 188.9 [+ or -] 82.1% (P < 0.05), respectively, were observed for mRNA expression of Smad7 and fibronectin in OB compared with Con muscles. In addition, enzymes involved in collagen synthesis, including lysyl oxidase, lysyl hydroxylase 2b, and prolyl 4-hydroxylase-[alpha]1, were increased by 350.2 [+ or -] 90.0 (P < 0.05), 236.5 [+ or -] 25.2 (P < 0.05), and 82.0 [+ or -] 36.2% (P = 0.05), respectively, in OB muscle. In conclusion, MO-enhanced fibrogenesis in fetal muscle in late gestation was associated with upregulation of the TGF-[beta]/p38 signaling pathway. Enhanced fibrogenesis at such an early stage of development is expected to negatively affect the properties of offspring muscle because muscle fibrosis is a hallmark of aging. collagen; maternal obesity; fetus doi: 10.1152/ajpendo.00015.2010.

Published
2010

104. Aldosterone antagonism fails to attenuate age-associated left ventricular fibrosis

Author

Hwang, Hyun Seok, Cirrincione, Georgina, Thomas, D. Paul, McCormick, Richard J., and Boluyt, Marvin O.

Subjects
Fibrosis -- Drug therapy, Fibrosis -- Demographic aspects, Aldosterone -- Properties, Aldosterone -- Influence, Aging -- Health aspects, Aging -- Influence, Heart ventricle, Left -- Research, Spironolactone -- Properties, Spironolactone -- Influence, Hypertension -- Drug therapy, Hypertension -- Demographic aspects, Collagen -- Control, Health, Seniors
Abstract

Collagen accumulates disproportionately in cardiac remodeling induced by hypertension and associated with advancing age. Spironolactone (Spiro), an aldosterone antagonist, attenuates the accumulation of collagen induced by hypertension. It was hypothesized that Spiro would attenuate the age-associated increase in percent collagen in the heart. Female Fisher 344 rats at 3 months (Y), 12 months (M), and 21 months (O) of age were treated with Spiro (30 mg/kg/d) or vehicle (Veh) for 2 months, yielding six groups: Y-Veh, Y-Spiro, M-Veh, M-Spiro, O-Veh, and O-Spiro. Hearts were harvested for immunoblotting, RNA blotting, and biochemical analysis. Percent collagen in the left ventricle and septum was greatest in the oldest rats. Spiro did not significantly attenuate the age-associated increase in collagen fraction or the age-associated increases in expression of atrial natriuretic factor and [beta]-myosin heavy chain messenger RNA. Chronic aldosterone antagonism does not attenuate the age-associated increase in collagen fraction in the female Fisher 344 rat heart.

Published
2007

105. Platelet rich plasma injection for acute Achilles tendon rupture: PATH-2 randomised, placebo controlled, superiority trial

Author

Keene, David J, Alsousou, Joseph, Harrison, Paul, Hulley, Philippa Anne, Wagland, Susan, Parsons, Scott R, Thompson, Jacqueline, O'Connor, Heather M, Schlussel, Michael Maia, Dutton, Susan J, Lamb, Sarah E, Willett, Keith, Handley, Robert, Lewis, Kathryn, Spoors, Louise, Zhang, Yuhan, Mestre, Maria, Muller, Doreeen, Prasath, Sangeetha, Austin, Martin, Bhatia, Maneesh, Attwal, Manjit, Christie, Carla, Brear, Tracy, Kelly, Andrew, Beacham, Keira, Brown, Sarah, Allen, James, Whitcher, Alison, James, Kate, Foster, Eliza, Hepple, Steve, Barnfield, Steven, Coates, Katherine, Halliday, Ruth, Hooper, Lucille, Hodgson, Paul, Hodgson, Helen, Cleary, Cheryl, Nott, Claire, Whiteman, Jessica, Carmont, Michael, Tonics, Louise, Heidari, Nima, Kassam, Jamila, Hilton, Catherine, Ahmad, Shanaz, Young, Sophie, Young, Jonathan, Clarkson, Louise, Turner, Sylvia, McGowan, Kerri, Lowe, Janet, Stables, Gareth, Bunworth, Kerry, de Feyter, Pascal, Ravindran, Ranjith, Vertue, Mark, Frostick, Simon, Maitland, Kate, Stokes-Denson, Joanne, Watson, Lisa, Scanlon, Deborah, Walker, Philip, Carmichael, James, O'Sullivan, Susie, Butcher, Deborah, Topliss, Claire, Hutchison, Anne-Marie, Storton, Sharon, Cook, Amanda, Quinn, Leanne, Mason, Lyndon, Earley, Joanne, Ballal, Moez, Bradley-Potts, Joanne, Williamson, Georgina, McCormick, Richard, Davies, Mark, Walker, Julie, Badloe, Joanne, Hughes, Adrian, Grice, Anna, Dark, Jayne, Barnes, Simon, Velpula, Jagan, Amor, Kelly, Brown, Janet, Solan, Matthew, and Grp, PATH-2 Trial

Subjects
Adult, Male, Heel, Visual analogue scale, Placebo, Conservative Treatment, Achilles Tendon, law.invention, Injections, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Quality of life, law, Tendon Injuries, medicine, Humans, Patient Reported Outcome Measures, Rupture, 030222 orthopedics, Intention-to-treat analysis, business.industry, Platelet-Rich Plasma, Research, Muscles, 030229 sport sciences, General Medicine, Recovery of Function, Middle Aged, United Kingdom, Tendon, medicine.anatomical_structure, Treatment Outcome, Anesthesia, Quality of Life, Female, Achilles tendon rupture, medicine.symptom, business
Abstract

Objective To determine whether an injection of platelet rich plasma improves outcomes after acute Achilles tendon rupture. Design Randomised, placebo controlled, two arm, parallel group, participant and assessor masked, superiority trial. Setting Secondary care trauma units across 19 hospitals in the United Kingdom’s health service. Participants Recruitment commenced in July 2015 and follow-up was completed in March 2018. 230 adults aged 18 years and over were included, with acute Achilles tendon rupture presenting within 12 days of injury and managed with non-surgical treatment. Exclusions were injury at the insertion or musculotendinous junction, major leg injury or deformity, diabetes mellitus, platelet or haematological disorder, systemic corticosteroids, anticoagulation treatment, and other contraindicating conditions. Interventions Participants were randomised 1:1 to platelet rich plasma (n=114) or placebo (dry needle; n=116) injection. All participants received standard rehabilitation care (ankle immobilisation followed by physiotherapy). Main outcomes and measures Primary outcome was muscle tendon function at 24 weeks, measured objectively with the limb symmetry index (injured/uninjured×100) in maximal work done during the heel rise endurance test (an instrumented measure of repeated single leg heel rises until fatigue). Secondary outcomes included patient reported function (Achilles tendon rupture score), quality of life (short form 12 version 2®), pain (visual analogue scale), goal attainment (patient specific functional scale), and adverse events. A central laboratory analysed the quality and content of platelet rich plasma. Analyses were by modified intention to treat. Results Participants were 46 years old on average, and 57 (25%) of 230 were female. At 24 weeks, 202 (88%) participants completed the heel rise endurance test and 216 (94%) the patient reported outcomes. The platelet rich plasma was of good quality, with expected growth factor content. No difference was detected in muscle tendon function between participants receiving platelet rich plasma injections and those receiving placebo injections (limb symmetry index, mean 34.7% (standard deviation 17.7%) v 38.5% (22.8%); adjusted mean difference −3.9% (95% confidence interval −10.5% to 2.7%)) or in any secondary outcomes or adverse event rates. Complier average causal effect analyses gave similar findings. Conclusions There is no evidence to indicate that injections of platelet rich plasma can improve objective muscle tendon function, patient reported function, or quality of life after acute Achilles tendon rupture compared with placebo, or that they offer any patient benefit. Trial registration ISRCTN54992179.

Published
2019

106. Impacts of motivation for change on the severity of alcohol use by patients with severe and persistent mental illness *

Author

Zhang, Amy Y., Harmon, Julie A., Werkner, Janet, and McCormick, Richard Arthur

Subjects
Motivation (Psychology), Drinking of alcoholic beverages, Mentally ill, Health, Psychology and mental health
Abstract

Objective: This study examined the effect of motivation for change, measured by the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES), on alcohol use severity among alcoholic patients with severe and persistent mental illness. Method: At a Veterans Affairs hospital, 390 dually diagnosed patients were recruited and assessed for motivation for change, alcohol use severity, psychotic symptoms and global functioning at baseline and 9-month follow-up. Results: Regression analyses showed that patients who were highly ambivalent about their alcohol use at baseline consumed significantly more alcohol 9 months later, on the basis of Addiction Severity Index ratings (p ≤ .01), than patients who felt less ambivalent. Conclusions: The findings suggest that increased awareness of alcohol-related problems is essential to reducing alcohol use severity for alcoholic patients with severe and persistent mental illness. The implications and limitations of the findings are discussed., SUBSTANCE USE DISORDERS are prevalent among patients with severe and persistent mental illness. The Epidemiologic Catchment Area (ECA) study reports that 47% of patients with a lifetime diagnosis of schizophrenia [...]

Published
2004

107. Unloading-induced remodeling in the normal and hypertrophic left ventricle

Author

McGowan, Brian S., Scott, Christopher B., Mu, Anbin, McCormick, Richard J., Thomas, D. Paul, and Margulies, Kenneth B.

Subjects
Human physiology -- Research, Cardiomyopathy -- Physiological aspects, Atrophy, Muscular -- Physiological aspects, Heart diseases, Biological sciences
Abstract

To date, no study has assessed the degree of similarity between left ventricular (LV) reverse remodeling and atrophic remodeling. Stable LV hypertrophy was induced by creation of an arteriovenous fistula (AVF) in Lewis rats (32 days). LV unloading was induced by heterotopic transplantation of normal (NL-HT) and/or hypertrophic (AVF-HT) hearts (7 days). We compared indexes of remodeling in AVF, NL-HT, and AVF-HT groups with those of normal controls. LV unloading induced decreases in cardiomyocyte size in NL-HT and AVF-HT hearts. NL-HT and AVF-HT LV were both characterized by relative increases in collagen concentration that were largely a reflection of decreases in myocyte volume. NL-HT and AVF-HT LV were associated with similar increases in matrix metalloproteinase (MMP-2 and -9) zymographic activity, without change in the abundance of the tissue inhibitors of the MMPs. In contrast, AVF-HT, but not NL-HT, was associated with a dramatic increase in collagen cross-linking. Our findings suggest an overall similarity in the response of the normal and hypertrophic LV to surgical unloading. However, the dramatic increase in collagen cross-linking after just 1 wk of unloading suggests a potential difference in the dynamics of collagen metabolism between the two models. Further studies will be required to determine the precise molecular mechanisms responsible for these differences in extracellular matrix regulation. However, with respect to these and related issues, heterotopic transplantation of hypertrophied hearts will be a useful small animal model for defining mechanisms of myocyte-matrix interactions during decreased loading conditions. myocardial atrophy; reverse remodeling; extracellular matrix; volume overload

Published
2003

110. Suicide prevalence in chemical dependency programs: preliminary data from a national sample, and an examination of risk factors

Author

Kausch, Otto and McCormick, Richard Arthur

Subjects
Suicide -- Risk factors, Substance abuse -- Psychological aspects, Health
Abstract

Completed suicides over a one year period of time were reported from a nationwide survey of Department of Veteran Affairs medical centers. Of a total of 248 completed suicides, 11 occurred in outpatient substance abuse programs, and an additional 5 occurred among patients receiving combined outpatient substance abuse and psychiatric treatment. There were no inpatient suicides. During this time, there were 7 suicide attempts on inpatient units and 37 suicide attempts in outpatient chemical dependency treatment. The majority of suicides were committed by males who had a primary alcohol addiction (63%). Thirty-eight percent of the sample had a comorbid mood disorder and 38% had a comorbid personality disorder. Risk factors relating to the potential for suicide in chemical dependency programs are discussed. Keywords: Suicide; Chemical dependency treatment; Assessing suicide risk; Suicide in treatment programs; Suicide attempts

Published
2002

112. Prophylactic biological mesh reinforcement versus standard closure of stoma site (ROCSS): a multicentre, randomised controlled trial

Author

Bhangu, Aneel, primary, Nepogodiev, Dmitri, additional, Ives, Natalie, additional, Magill, Laura, additional, Glasbey, James, additional, Forde, Colm, additional, Bisgaard, Thue, additional, Handley, Kelly, additional, Mehta, Samir, additional, Morton, Dion, additional, Pinkney, Thomas, additional, Bhangu, Aneel, additional, Brown, James, additional, Futaba, Kaori, additional, Khan, Sarah, additional, Pallan, Arvind, additional, Patel, Abhilasha, additional, Ashdown-Phillips, Steve, additional, Roberts, Tracy, additional, Jowett, Susan, additional, Munetsi, Lorraine, additional, Torrance, Andrew, additional, Hilken, Nicholas, additional, Hill, Matt, additional, Hunter, Mark, additional, Leek, Susan, additional, Lilly, Helen, additional, Sawant, Amruta, additional, Vince, Alexandra, additional, Walters, Michael, additional, Bemelman, Willem, additional, Blussé, Marjolein, additional, Borstlap, Wernard, additional, Busch, Olivier RC, additional, Buskens, Christianne, additional, Klaver, Charlotte, additional, Marsman, Hendrik, additional, van Ruler, Oddeke, additional, Tanis, Pieter, additional, Westerduin, Emma, additional, Wicherts, Dennis, additional, Das, Parthasarathi, additional, Essapen, Sharadah, additional, Frost, Victoria, additional, Glennon, Ana, additional, Gray, Catherine, additional, Hussain, Anwar, additional, McNichol, Lisa, additional, Nisar, Pasha, additional, Scott, Humphrey, additional, Trickett, Jonathan, additional, Trivedi, Prateesh, additional, White, Daniel, additional, Amarnath, Talakalukoppa, additional, Ardley, Rohan, additional, Gupta, Robin, additional, Hall, Emily, additional, Hodgkins, Kathryn, additional, Narula, Harjeet, additional, Sewell, Terri-Ann, additional, Simms, John M, additional, Toms, Julie, additional, White, Tim, additional, Atkinson, Angela, additional, Beral, Dan, additional, Lancaster, Nicola, additional, Mackenzie, Felicity, additional, Wilson, Tim, additional, Cruttenden-Wood, David, additional, Gibbins, Jackie, additional, Halls, Mark, additional, Hill, Dennise, additional, Hogben, Karen, additional, Jones, Stephanie, additional, Lamparelli, Michael J, additional, Lewis, Mark, additional, Moreton, Sarah, additional, Ng, Paul, additional, Oglesby, Arabis, additional, Orbell, James, additional, Stubbs, Benjamin, additional, Subramanian, Krishnan, additional, Talwar, Anjay, additional, Wilsher, Simon, additional, Al-Rashedy, Mohammed, additional, Fensom, Catherine, additional, Gok, Muhammed, additional, Hardstaff, Lisa, additional, Malik, Kamran, additional, Sadat, Mohammed, additional, Townley, Barbara, additional, Wilkinson, Lesley, additional, Cosier, Tracey, additional, Mangam, Sudhakar, additional, Rabie, Mohamed, additional, Broadley, Graham, additional, Canny, John, additional, Fallis, Simon, additional, Green, Nikki, additional, Hawash, Ahmed, additional, Karandikar, Sharad, additional, Mirza, Mehboob, additional, Rawstorne, Edward, additional, Reddan, Julie, additional, Richardson, Jonathan, additional, Thompson, Chris, additional, Waite, Kathryn, additional, Youssef, Haney, additional, De Nes, Lindsey, additional, Rosenstock, Steffen, additional, Strandfelt, Pernille, additional, Westen, Mikkel, additional, Aryal, Kamal, additional, Kshatriya, Kirosh Shankar, additional, Lal, Roshan, additional, Velchuru, Vamsi, additional, Wilhelmsen, Elva, additional, Akbar, Ayesha, additional, Antoniou, Anthony, additional, Clark, Sue, additional, Datt, Pooja, additional, Goh, Jason, additional, Jenkins, Ian, additional, Kennedy, Robin, additional, Maeda, Yasuko, additional, Nastro, Piero, additional, Owen, Harriet, additional, Phillips, Robin KS, additional, Warusavitarne, Janindra, additional, Bradley-Potts, Joanne, additional, Charleston, Peter, additional, Clouston, Hamish, additional, Duff, Sarah, additional, Fatayer, Taher, additional, Gipson, Anna, additional, Heywood, Nick, additional, Junejo, Muneer, additional, Kennedy, James, additional, Lalor, Helen, additional, Manning, Chris, additional, McCormick, Richard, additional, Parmar, Kathryn, additional, Preston, Stephen, additional, Ramesh, Aswatha, additional, Sharma, Abhiram, additional, Telford, Karen, additional, Adeosun, Abidemi, additional, Hammond, Toby, additional, Smolen, Susan, additional, Topliffe, Joanne, additional, Docherty, James G, additional, Lim, Michael, additional, Macleod, Kathleen, additional, Monaghan, Eimar, additional, Patience, Lesley, additional, Thomas, Ian, additional, Walker, Kenneth G, additional, Walker, Michael, additional, Watson, Angus JM, additional, Burgess, Amanda, additional, Ghanem, Yasser, additional, Glister, Georgina, additional, Kapur, Sandeep, additional, Paily, Abhilash, additional, Pal, Atanu, additional, Ravikumar, Rathinam, additional, Rosbergen, Melissa, additional, Sargen, Kevin, additional, Speakman, Christopher, additional, Agarwal, Anil K, additional, Banerjee, Amlan, additional, Borowski, David, additional, Garg, Dharmendra, additional, Gill, Talvinder, additional, Johnston, Tracey, additional, Kelsey, Susan, additional, Munipalle, Phanibhushana Chakravarthy, additional, Tabaqchali, Mohamed, additional, Wilson, Deborah, additional, Acheson, Austin, additional, Cripps, Heather, additional, El-Sharkawy, Ahmed, additional, Ng, Oliver, additional, Sharma, Parveen, additional, Ward, Kym, additional, Chandler, Dawne, additional, Courtney, Edward, additional, Bunni, John, additional, Butcher, Katrina, additional, Dalton, Stephen, additional, Flindall, Ian, additional, Katebe, Joyce, additional, Roy, Pratik, additional, Tate, Jeremy, additional, Vincent, Tracy, additional, Williamson, Michael ER, additional, Wood, James, additional, Bignell, Mark, additional, Branagan, Graham, additional, Broardhurst, Jack, additional, Chave, Helen, additional, Dean, Hilary, additional, D'Souza, Nigel, additional, Foster, Gemma, additional, Sleight, Simon, additional, Sutaria, Rupesh, additional, Ahmed, Ishmail, additional, Budhoo, Misra Rai, additional, Colley, Julie, additional, Cruickshank, Neil, additional, Gill, Kathryn, additional, Hayes, Anne, additional, Joy, Howard, additional, Kamabjha, Carrington, additional, Plowright, James, additional, Radley, Simon, additional, Rea, Mr, additional, Thumbe, Vijay, additional, Varghese, Philip, additional, Wilkin, Richard, additional, Zulueta, Elzbieta, additional, Allsop, Lynne, additional, Atkari, Bence, additional, Badrinath, Krishnamurthy, additional, Daliya, Prita, additional, Dube, Mukul, additional, Heeley, Cheryl, additional, Hind, Richard, additional, Nash, Dominic, additional, Palfreman, Andrea, additional, Peacock, Oliver, additional, Watson, Nicholas, additional, Blodwell, Michelle, additional, Javaid, Ali, additional, Mohamad, Ashiq, additional, Muhammad, Karim, additional, Qureshi, Nafees, additional, Ridgway, Stephanie, additional, Siddiqui, Kamran, additional, Solkar, Mamoon, additional, Vere, Joanne, additional, Wordie, Alexander, additional, Chang, Jessica, additional, Elgaddal, Sanaa, additional, Green, Marie, additional, Hollyman, Marianne, additional, Mirza, Nazzia, additional, Rankin, Jayne, additional, Williams, Graham, additional, Ali, Wadah, additional, Hardwick, Anne, additional, Mohamed, Zakir, additional, Navid, Ahmad, additional, Netherton, Kimberley, additional, Obreja, Mugurel, additional, Rao, Milind, additional, Stringer, Joanna, additional, Tennakoon, Athula, additional, Bullen, Timothy, additional, Butt, Mansoor, additional, Dawson, Robin, additional, Dawson, Sarah, additional, Farmer, Martin, additional, Garimella, Veerabhadram, additional, Gates, Zoe, additional, Wilkings, Lisa, additional, Yeomans, Neil, additional, Adedeji, Olufunso, additional, Alalawi, Rashid, additional, Al Araimi, Aamed, additional, Ashraf, Shazad, additional, Bach, Simon, additional, Beggs, Andrew, additional, Cagigas, Carmen, additional, Dattani, Mit, additional, Dimitriou, Nikolletta, additional, Ghods-Ghorbani, Manijeh, additional, Gourevitch, David, additional, Haydon, Geoffrey, additional, Ismail, Tariq, additional, Keh, Christopher, additional, Morton, Dion G, additional, Narewal, Mandip, additional, Papettas, Trifonas, additional, Pinkney, Tom, additional, Poh, Aaron, additional, Ranstorne, Edward, additional, Royle, Timothy J, additional, Shah, Tahir, additional, Singh, Jagdeep, additional, Smart, Chris, additional, Suggett, Nigel, additional, Tayyab, Muhammad, additional, Vijayan, Deepak, additional, Vohra, Ravinder, additional, Wairaich, Naseem, additional, Yeung, Denise, additional, Bamford, Richard, additional, Chambers, Joanne, additional, Cotton, David, additional, Houlihan, Rebecca, additional, Kynaston, James, additional, Longman, Rob, additional, Lowe, Amelia, additional, Messenger, David, additional, Owais, Anwar, additional, Phillpott, Catherine, additional, Shabbir, Jamshed, additional, Baragwanath, Phil, additional, El-Sayed, Charlotte, additional, Gaunt, Anne, additional, Khatri, Chetan, additional, McCullough, Peter, additional, Ward, Stephen, additional, Obukofe, Ross, additional, Stroud, Robert, additional, Mason, David, additional, Williams, Nigel, additional, Wong, Ling S, additional, Chaudhri, Sanjay, additional, Cooke, Jill, additional, Cunha, Melissa, additional, Fairey, Howard, additional, Norwood, Michael, additional, Singh, Baljit, additional, Thomasset, Sarah, additional, Abbott, Sian, additional, Addison, Sarah, additional, Archer, James, additional, Church, Robert, additional, Holford, Erika, additional, Lenehan, Fionnaula, additional, Odogwu, Steve, additional, Richardson, Lisa, additional, Sidebotham, Jane, additional, Swan, Elaine, additional, Tilley, Alison, additional, Wagstaff, Lynda, additional, Amey, Isobel, additional, Baird, Yolanda, additional, Cripps, Neil, additional, Greenslade, Susanna, additional, Harris, Guy, additional, Levy, Bruce, additional, Mckenzie, Paul, additional, Misselbrook, Alison, additional, Moore, Sally, additional, Skull, Angela, additional, Nicol, Deborah, additional, Reddy, Bala, additional, Thrush, Jessica, additional, Iglesias Vecchio, Miriam, additional, Dunn, Yvonne, additional, Williams, Claire, additional, Furtado, Sanjay, additional, Gill, Michael, additional, Gilmore, Lydia, additional, Goldsmith, Paul, additional, Kocialkowski, Cezary, additional, Loganathan, Sadasivam, additional, Nath, Rabindra, additional, Paraoan, Marius, additional, Taylor, Tracey, additional, Allison, Andrew, additional, Allison, Joanna, additional, Curtis, Nathan, additional, Dalton, Richard, additional, D'Costa, Conrad, additional, Dennison, Godwin, additional, Foster, Jake, additional, Francis, Nader, additional, Gibbons, James, additional, Hamdan, Mohammed, additional, Lewis, Alison, additional, Ockrim, Jonathan, additional, Sharma, Rishabha, additional, Spurdle, Katie, additional, Varadharajan, Saseendran, additional, Aghahoseini, Assad, additional, Alexander, David J, additional, Bandyopadhyay, Dibyendu, additional, Bradford, Ian, additional, Chitsabesan, Praminthra, additional, Coleman, Zoe, additional, Gibson, Andrew, additional, Lasithiotakis, Kostas, additional, Panagiotou, Dimitrios, additional, Polyzois, Konstantinos, additional, Stojkovic, Stevan, additional, Woodcock, Nicholas, additional, Wright, Monica, additional, Hargest, Rachel, additional, Jackson, Richard, additional, Rajesh, Arumugam, additional, Ogunbiyi, Olagunju, additional, Slater, Andrew, additional, and Yu, Ly-Mee, additional

Published
2020
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113. Effectiveness of Specialized Treatment Programs for Veterans With Serious and Persistent Mental Illness: A Three-Year Follow-Up

Author

Blow, Frederic C., Ullman, Esther, Barry, Kristen Lawton, Bingham, C. Raymond, Copeland, Laurel A., McCormick, Richard, and Van Stone, William

Subjects
Mental illness -- Care and treatment, Hospitals, Veterans' -- Research, Health, Psychology and mental health
Abstract

This is the first study to test concurrently the effectiveness of four treatment programs for patients with serious mental illness. Three-year outcome data on utilization and functioning demonstrated important positive changes for seriously mentally ill veterans enrolled in specialized, enhanced inpatient and community case management treatment programs, when compared to patients in an enhanced day treatment program or traditional standard care.

Published
2000

114. Higher Brain Blood Flow at Amygdala and Lower Frontal Cortex Blood Flow in PTSD Patients with Comorbid Cocaine and Alcohol Abuse Compared with Normals

Author

Semple, William E., Goyer, Peter F., McCormick, Richard, Donovan, Beverly, Muzic, Raymond F., Jr., Rugle, Loreen, McCutcheon, Kevan, Lewis, Colleen, Liebling, David, Kowaliw, Sean, Vapenik, Ken, Semple, Mary Ann, Flener, Christy R., and Schulz, S. Charles

Subjects
Post-traumatic stress disorder -- Physiological aspects, Blood flow -- Measurement, Cocaine abuse -- Physiological aspects, Alcoholism -- Physiological aspects, Amygdala (Brain) -- Research, Frontal lobes -- Research, Psychology and mental health
Abstract

Posttraumatic stress disorder (PTSD) patients with histories of cocaine and alcohol abuse (CA-PTSD) were compared with normal volunteers. Positron emission tomography (PET) scans with (super 15)O-butanol were used to compare regional cerebral blood flow (rCBF) between the groups during rest and during an auditory continuous performance task (ACPT). CA-PTSD patients had significantly higher rCBF in right amygdala and left parahippocampal gyrus than normals during the ACPT. Normals had higher rCBF at frontal cortex during the resting scan and during the ACPT. The role of the amygdala in attention and fear conditioning suggests that increased amygdala rCBF may be related to clinical features of PTSD. Cocaine use may be associated with increased amygdala rCBF in PTSD patients. Amygdala and frontal cortex attention system components may be reciprocally related and their relative contributions to processing of neutral stimuli perturbed in CA-PTSD.

Published
2000

118. Public Sector Collaboration for Agricultural IP Management

Author

Atkinson, Richard C., Beachy, Roger N., Conway, Gordon, Cordova, France A., Fox, Marye Anne, Holbrook, Karen A., Klessig, Daniel F., McCormick, Richard L., McPherson, Peter M., Rawlings, Hunter R., Rapson, Rip, Vanderhoef, Larry N., Wiley, John D., and Young, Charles E.

Published
2003

120. The relationship of neo-pi performance to coping styles, patterns of use, and triggers for use among substance abusers

Author

McCormick, Richard Arthur, Dowd, E. Thomas, Quirk, Stuart, and Zegarra, Juan Hernando

Subjects
Substance abuse -- Research, Drug abuse -- Research, Psychology, Pathological -- Measurement, Health, Sociology and social work
Abstract

NEO Personality Inventory (NEO-PI) data from male substance abusers undergoing treatment were analyzed to elucidate the relationship of neo-pi performance to coping mechanisms, patterns of abuse, and triggers for use. The results were then compared to the scores on measures of psychopathology that evaluate characteristics related to those incorporated in the NEO-PI. Extroversion, agreebleness and conscientiousness were found to be related to the greater confidence in the capability to avoid usage, while neuroticism was more related to the absence of confidence in self-control.

Published
1998

121. It's not obvious how much KSR changed anything.

Author

Lewis, Jeffrey I.D. and McCormick, Richard J.

Subjects
Patent licenses -- Laws, regulations and rules, Prior art (Patent law) -- Laws, regulations and rules, Patent infringement -- Laws, regulations and rules, KSR International Co. v. Teleflex, Inc. (127 S. Ct. 1727 (2007)), Government regulation, Patent Code of 1952 (35 U.S.C. 103)
Abstract

The Supreme Court's recent decision in KSR Int'l Co. v. Teleflex, Inc. (1) on the obviousness standard for patentability contains something for everyone. The Federal Circuit faithful will find the [...]

Published
2007

128. Aggression and hostility in substance abusers: the relationship to abuse patterns, coping style, and relapse triggers

Author

McCormick, Richard Arthur and Smith, Mark

Subjects
Substance abuse -- Care and treatment, Aggressiveness (Psychology) -- Analysis, Health, Sociology and social work
Abstract

Examination of the hostile and aggressive attitudes using the NEO Personality Inventory Hostility Scale of 3,367 substance abusers undergoing treatment revealed that multiple substance abusers scored substantially high on all the measures with frequent inclinations for escape avoidance, distancing and confrontational coping styles. Highly hostile and aggressive patients experienced more episodes that triggered substance use and reported lower confidence in resisting use during adverse situations.

Published
1995

129. Testing a tripartite model: I. Evaluating the convergent and discriminant validity of anxiety and depression symptom scales

Author

Watson, David, Clark, Lee Anna, Weber, Kris, Assenheimer, Jana Smith, Strauss, Milton E., and McCormick, Richard Arthur

Subjects
Depression, Mental -- Identification and classification, Diagnosis -- Observations, Psychology and mental health
Abstract

A tripartite model enables the grouping of depression symptoms to three types, namely, the indications of somatic tension and arousal that are specific to anxiety, nonspecific symptoms of general stress and symptoms of anhedonia and low Positive Affect unique to depression. The results from this model are consistent with the MASQ Anxious Arousal and Anhedonic Depression scales. Thus, an understanding of the several symptoms enables a comprehension of the depression phenomena.

Published
1995

130. Testing a tripartite model: II. Exploring the symptom structure of anxiety and depression in student, adult, and patient samples

Author

Watson, David, Clark, Lee Ana, Weber, Kris, Assenheimer, Jana Smith, Strauss, Milton E., and McCormick, Richard Arthur

Subjects
Depression, Mental -- Research, Diagnosis -- Analysis, Anxiety -- Analysis, Psychology and mental health
Abstract

A study of a tripartite model of depression and anxiety by separate factor analysis of three students, one adult and a patient revealed symptom structures to be similar for diverse groups of people. The three symptom groups proposed by the model are non-specific general distress, somatic arousal related to anxiety and symptoms of anhedonia pertaining to depression.

Published
1995

132. The Writings of Theobald Wolfe Tone 1763–98, Vol. 1: Tone's Career in Ireland to June 1795

Author

Russell, Thomas, primary, Tone, Theobald Wolfe, additional, Canterbury, George Abbot, archbishop of, additional, Burke, Richard, additional, Burrowes, Peter, additional, Emmet, Thomas Addis, additional, [Witherington], Matilda [Martha] Tone, additional, Simms, Robert, additional, Haliday, Dr Alexander Henry, additional, MacDermot, Dr Hugh, additional, Jones, William Todd, additional, Mooney, James, additional, Barry, Col. Henry, additional, Grattan, Henry, additional, Devereux, James Edward, additional, Neilson, Samuel, additional, Lord, Rawdon,, additional, [McDonnell], Randal MacDonnell, additional, Lord, Fitzgibbon,, additional, Pollock, Joseph, additional, McCormick, Richard, additional, Lord, Moira,, additional, Beresford, Marcus, additional, Tone, Mary, additional, O'Connor, Rowland J., additional, Knox, George, additional, Plunket, William Conyngham, additional, Duigenan, Patrick, additional, [Dawson], Sarah Anne Hamilton Rowan, additional, Beresford, John, additional, Rowan, Archibald Hamilton, additional, Dundas, Henry, additional, Dabzac, Henry, additional, Murray, Richard, additional, Fitzgerald, Gerald, additional, Ussher, Henry, additional, Young, Matthew, additional, Hales, William, additional, Hely-Hutchinson, John, additional, Drought, James, additional, Allen, John, additional, Greene, Molesworth, additional, Pottinger, Eldred, additional, Heyland, Charles, additional, Barber, Rev. Samuel, additional, Bell, Capt. Robert Adair, additional, [Macabe], Thomas McCabe, additional, [Haslitt], Henry Haslett, additional, Hyndman, James, additional, Rabb, John, additional, Hastings, Elizabeth Rawdon [Hastings], counte, additional, Bell, David, additional, Keogh, John, additional, Butler, Simon, additional, Burston, Beresford, additional, [Sinclaire], William Sinclair, additional, Byrne, Edward, additional, Bellew, Christopher Dillon, additional, baronet, Sir Thomas French, second, additional, Moira, Francis Rawdon Hastings, first marq, additional, Sweetman, John, additional, Russell, Thomas, additional, Darling, Sisson Putland, additional, Clare, John FitzGibbon, first earl of, additional, Galtrim, John Hussey, baron of, additional, Plunket, William Conyngham Plunket, first Ba, additional, McCracken, Henry Joy, additional, Aubigny, Charles Lennox, third duke of Richm, additional, Grenville, William Wyndham Grenville, Baron, additional, and Bernard, Scrope, additional

Published
1998
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134. Some early reactions to 'Veritatis spendor.' (encyclical letter signed August 6, 1993)

Author

McCormick, Richard Arthur

Subjects
Catholic Church, Catholic authors, Christian ethics, Encyclicals, Papal -- Criticism and interpretation, Philosophy and religion, Criticism and interpretation
Abstract

VERITATIS SPLENDOR has elicited a broad range of reactions, both favorable and unfavorable. In this article, I shall first review comments on, responses to, and studies of the papal letter, [...]

Published
1994

135. Regional differences in LV collagen accumulation and mature cross-linking after myocardial infarction in rats

Author

McCormick, Richard J., Musch, Timothy I., Bergman, Bryan C., and Thomas, D. Paul

Subjects
Extracellular matrix -- Research, Collagen -- Analysis, Heart attack -- Analysis, Biological sciences
Abstract

Experiments on the rat left ventricular free wall reveal that extracellular matrix (ECM) response and constituent collagen changes are essential components of post-myocardial infarction (MI) myocardium. The left ventricular wall scar exhibits elevated collagen and hydroxylsylpyridinoline (HP) levels after MI. THe HP concentration indicates that covalent cross-linking of collagen fibrils varies regionally in the ECM.

Published
1994

136. Copper deficiency alters collagen types and covalent cross-linking in swine myocardium and cardiac valves

Author

Vadlamudi, Ratna K., McCormick, Richard J., Medeiros, Denis M., Vassoughi, Jafar, and Failla, Maric C.

Subjects
Hypocupremia -- Research, Collagen -- Ultrastructure, Biological sciences
Abstract

A diet deficient in copper results in altered connective tissue metabolism responsible for lesions in cardiovascular and other organ systems, and affects the structural and functional features of collagen and elastin by causing abnormal collagen and elastin cross-linking. Extensive restructuring of collagen fraction of cardiac interstitium occurs due to Cu deficiency. Cardiac hypertrophy arises due to impaired left ventricular collagen cross-linking, resulting in enhanced compliance of the ventricular wall.

Published
1993

147. Changing my mind about the changeable church

Author

McCormick, Richard Arthur

Subjects
Catholic Church, Second Vatican Council, 1962-1965 -- Influence, Priests -- Beliefs, opinions and attitudes, Christian ethics -- Evaluation
Published
1990

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