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C27H20FN3S2Sn, monoclinic, P21/n (no. 14), a = 15.631(4) Å, b = 9.865(3) Å, c = 17.256(3) Å β = 108.335(11)°, V = 2525.8(10) Å3, Z = 4, Rgt(F) = 0.0398, wRref(F2) = 0.0917, T = 298 K. [ABSTRACT FROM AUTHOR]

Carbon dioxide flooding can accelerate the development of low-permeability reservoirs of the Kexia group in the K region of the T oil field, thus resolving the issue of inadequate water drive effects. This study was focused on the well group 80513 in the K region, and based on the reservoir and fluid parameters, a simulation model of water-sensitive post-CO 2 flooding was constructed to refine the gas injection strategy gradually. The injection rate of the continuous gas injection stage was preferred based on the degree of recovery. Multiindicator and multifactor injection and extraction schemes were established to optimize and analyze the key controlling factors, including the gas injection rate, gas injection period, gas-to-water ratio, and bottom-hole flow pressure, in the carbon dioxide gas-to-water alternation process. Recovery efficiency, oil exchange rate, formation pressure, and carbon dioxide storage rate were used as indicators. After 5 years of continuous CO 2 flooding, the results indicated that switching to CO 2 gas-water alternating flooding was more appropriate for the target block's environment. The best development plan was achieved when the gas injection rates were 1.0 and 1.25 × 10 4 m 3 ·d -1 for continuous gas injection and CO 2 gas-water alternating flooding, respectively, with a gas-water ratio of 1:1, a gas injection cycle of 90 days, and a bottom-hole flow pressure of 25 MPa in the production wells. A comparison between the results revealed that the formation pressure and oil recovery efficiency of this well group significantly increased upon CO 2 flooding, and the parameter optimization results were well suited for controlling the gas flurry, offering a versatile model for future development of the block., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)

Numerous studies have demonstrated the important roles of epigenetic modifications in tumorigenesis, progression and prognosis. However, in hepatocellular carcinoma, the potential link between N 7 -methylguanosine (m 7 G) modification and molecular heterogeneity and tumor microenvironment (TME) remains unclear., Method: We performed a comprehensive evaluation of m 7 G modification patterns in 816 hepatocellular carcinoma samples based on 24 m 7 G regulatory factors, identified different m 7 G modification patterns, and made a systematic correlation of these modification patterns with the infiltration characteristics of immunocytes. Then, we built and validated a scoring tool called m 7 G score., Results: In this study, we revealed the presence of three distinct m 7 G modification patterns in liver cancer, with remarkable differences in the immunocyte infiltration characteristics of these three subtypes. The m 7 G scoring system of this study could assess m 7 G modification patterns in individual hepatocellular carcinoma patients, could predict TME infiltration characteristics, genetic variants and patient prognosis. We also found that the m 7 G scoring system may be useful in guiding patients' clinical use of medications., Conclusions: This study revealed that m 7 G methylation modifications exerted a significant role in formation of TME in hepatocellular carcinoma. Assessing the m 7 G modification patterns of single patients would help enhance our perception of TME infiltration characteristics and give significant insights into immunotherapy efficacy., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Wang, Hu, Liu, Feng, Zhang, Han, Liu and Meng.)

In the crystal structure of the title compound, C(5)H(6)N(6)S(4), the mol-ecules are linked by strong N-H⋯N hydrogen bonds into a two-dimensional network and an intra-molecular C-H⋯S inter-action also occurs.

In the title mononuclear complex, [Ni(C(4)H(5)O(2))(2)(C(10)H(9)N(3))]·1.5H(2)O, the Ni(II) ion is in a distorted square-planar coordination environment, formed by two O atoms from two methacrylate ligands and two N atoms from a bis-chelating dipyridylamine ligand. In the crystal structure, inter-molecular O-H⋯O and N-H⋯O hydrogen bonds link complex mol-ecules and water mol-ecules into one-dimensional chains.