101. Low serum Insulin Like Growth Factor - 1 in patients with Stress Urinary Incontinence
- Author
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Emin Ozbek, Feti Tulubas, Suleyman Sahin, Mustafa Baki Cekmen, Alper Otunctemur, Murat Dursun, Emrecan Polat, and Levent Ozcan
- Subjects
Igf-1 ,Adult ,medicine.medical_specialty ,Urinary Incontinence, Stress ,Urology ,medicine.medical_treatment ,Periurethral Connective-Tissue ,Serum insulin ,030232 urology & nephrology ,Expression ,Urinary incontinence ,Enzyme-Linked Immunosorbent Assay ,Urine ,Stress ,lcsh:RC870-923 ,03 medical and health sciences ,0302 clinical medicine ,Prolapse ,Urethral pressure ,Early prediction ,Humans ,Medicine ,Women ,In patient ,Prospective Studies ,Insulin-Like Growth Factor I ,Gynecology ,030219 obstetrics & reproductive medicine ,business.industry ,Biochemical-Composition ,Growth factor ,Therapeutic effect ,Pelvic Floor ,Middle Aged ,lcsh:Diseases of the genitourinary system. Urology ,Continent ,Urinary Incontinence ,Case-Control Studies ,Original Article ,Female ,Collagen ,medicine.symptom ,business - Abstract
WOS: 000391024000022 PubMed ID: 27564291 Objective: SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in women. Recent animal study has shown that there are therapeutic effects of Insulin-like growth factors (IGF-1) on stress urinary incontinence in rats with simulated childbirth trauma. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues and stimulates fibroblast proliferation and enhances collagen synthesis. The purpose of the current study was to determine the association between IGF-1 levels and SUI. Materials and Methods: All patients were evaluated for SUI and divided into two groups: 116 women with SUI and 76 women without SUI. Diagnosis of SUI was based on the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). Levels of IGF-1 were measured in serum by enzyme-linked immunosorbent assay. The relationship between IGF-1 levels and SUI in patients was evaluated statisticaly. Results: The mean age of patients wiyh SUI was 49.9 +/- 8.6 and 48.7 +/- 7.8 in control group. Plasma IGF-1 levels were significantly lower in SUI than in control group (106.5 +/- 26.4 and 133.3 +/- 37.1ng/mL, respectively, P < 0.001). Body mass indexes were higher in women with SUI than women without SUI. Conclusion: In this study lower serum IGF-1 levels were found to be associated with SUI. Serum IGF-1 level appears to be a specific predictor of SUI, and it may be used in early prediction of SUI in female population.