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This study investigated: 1) monitoring post-match neuromuscular fatigue (NMF) status in rugby union players using two submaximal running tests (SRT); and 2) the sensitivity of each SRT to locomotor variables obtained during match-play. Twenty-three male rugby players (age: 21.0 ± 1.3 years; height: 185.2 ± 6.1 cm; body mass; 97.3 ± 10.3 kg) were monitored across one season ( n  = 71 player-match and 159 fatigue-players-testing observations). Two different SRTs (SRT-jog [5-minute shuttle run protocol] and SRT-stride [a repeat stride effort protocol]) were used to characterise post-match NMF, with measures taken two days prior to match day (baseline), on MD + 1, and MD + 2. Linear mixed models (±90% CIs) were used to explore differences between measures and match-play locomotor variables. SRT-jog presented a meaningful increase following MD + 1 (ES: 0.63 [0.37 to 0.89]). SRT-Stride showed small increases at MD + 1 (ES: 0.24 [0.02 to 0.49]) and MD + 2 (ES: 0.33 [0.07 to 0.59]) suggesting a potential impairment in running mechanics. SRT-stride was significantly associated with total distance (ES: 0.41 [-0.01 to 0.83]) and collisions (ES: 0.58 [0.18 to 0.99]). While both tests presented small to moderate changes post-match, only the SRT-stride was related to match locomotor variables. Therefore, the SRT-stride may be a more sensitive monitoring tool for monitoring NMF in rugby union players.

The purpose of this study was to assess quantitatively the effects of compression garments (CGs) on fatigue behaviour during sport activities such as running, which are the subject of a series of qualitative and physiological studies. A quantitative biomechanical analysis of the effects of CGs could assist coaches and athletes to adopt these types of performance enhancement garments. In this research, kinematic changes are measured using 2D phase portraits to study the influence of CGs on fatigue behaviour. Fifteen healthy male intermediate athletes participated in this study and the kinematic data of hip repetitive movements with and without CG were measured during running tasks. These data are used to reconstruct the state space and the local flow variation method is adopted to quantify the trajectory drifts caused by fatigue in the state space. The effects of CGs on the complexity of kinematic changes are also evaluated using permutation entropy. The results indicate that fluctuations in the kinematics are reduced when compression garments are used. It is also shown that adoption of CGs results in a reduction of the rate of fatigue development and decreased complexities in the movement kinematics.

Purpose: To investigate the effects of 3 training volumes in the bench-press exercise performed with interrepetition rest periods, matched for fatigue, on strength gains and neuromuscular adaptations., Methods: Forty-three resistance-trained men were randomized into 3 groups: low (LOW), moderate (MOD), and high (HIG) volume. The intensities increased from 70% to 85% of 1-repetition maximum (1RM) over the 8-week training period. Each session consisted of only 1 set with short interrepetition rest periods. LOW performed only 3 repetitions per session (8-wk total: 48 repetitions); MOD completed 15, 12, 10, and 8 repetitions per session with 70%, 75%, 80%, and 85% 1RM, respectively (8-wk total: 180); and HIG performed 24, 21, 18, and 15 repetitions per session with 70%, 75%, 80%, and 85% 1RM, respectively (8-wk total: 312). Progressive loading and fatigue tests were conducted in the bench-press exercise before and after the training period. Electromyography (EMG) signals from the triceps brachii were registered during these tests., Results: HIG and MOD showed higher velocity loss than LOW (16% vs 12%). No significant group × time interaction was observed for any variable. All groups improved significantly in all strength-related variables, except for maximal unloaded velocity, where only MOD obtained significant gains. Only LOW and MOD induced significant improvements in EMG. MOD obtained the greatest effect sizes in almost all strength variables., Conclusions: No significant differences were found in the performance gains obtained by each group despite the wide differences in the total volume accumulated by each group.

Purpose: To determine the effects of repeated Brazilian jiujitsu (BJJ) matches on neuromuscular fatigue in forearm-flexor and knee-extensor muscles., Methods: Twelve BJJ athletes (8 men and 4 women) performed a simulated BJJ tournament composed of four 8-minute matches interspersed by 16-minute intervals. Neuromuscular fatigue was assessed via prematch to postmatch(es) reductions in maximal voluntary isometric contraction (MVIC), voluntary activation, and potentiated twitch force (Ptwpot) in the forearm-flexor and knee-extensor muscles., Results: The MVIC of the knee extensors and forearm flexors reduced from prematch 1 to postmatch 2 and remained suppressed until postmatch 4 (P < .034). The voluntary activation of the knee extensors declined only after match 4, whereas the voluntary activation of the forearm flexors did not change throughout the matches (P = .102). Ptwpot of knee extensors decreased from prematch 1 to postmatch 1 (P < .001) and remained reduced until postmatch 4 (P < .001). Ptwpot of the forearm flexors reduced after every match (P < .010), with complete recovery occurring only before the second match (P = .99). The magnitude of the prematch-to-postmatch reduction in Ptwpot was lower in knee extensors than in forearm flexors (P = .044)., Conclusions: Repeated BJJ matches induced neuromuscular fatigue, mainly due to impairments in muscle contractile function (ie, peripheral fatigue). The time between BJJ matches seems to be insufficient to allow complete recovery of neuromuscular function, which may influence performance during subsequent matches.

This study aims to optimize surface electromyography-based gesture recognition technique, focusing on the impact of muscle fatigue on the recognition performance. An innovative real-time analysis algorithm is proposed in the paper, which can extract muscle fatigue features in real time and fuse them into the hand gesture recognition process. Based on self-collected data, this paper applies algorithms such as convolutional neural networks and long short-term memory networks to provide an in-depth analysis of the feature extraction method of muscle fatigue, and compares the impact of muscle fatigue features on the performance of surface electromyography-based gesture recognition tasks. The results show that by fusing the muscle fatigue features in real time, the algorithm proposed in this paper improves the accuracy of hand gesture recognition at different fatigue levels, and the average recognition accuracy for different subjects is also improved. In summary, the algorithm in this paper not only improves the adaptability and robustness of the hand gesture recognition system, but its research process can also provide new insights into the development of gesture recognition technology in the field of biomedical engineering.

Objective: To investigate the effects of mild fatigue on the biomechanics of the lower limbs of young male volleyball players while performing single leg landing tasks., Methods: A total of ten young male volleyball players were recruited as participants in this study. After the single leg landing was performed, we compared the performance between those with and without fatigue (post- and non-fatigue, respectively). Kinematics and kinetics were collected using instruments, and related captured data were imported into OpenSim to analyze the hip, knee, and ankle joints., Results: We found that the ankle dorsiflexion angle at initial contact was significantly decreased in the post-fatigue group compared to the non-fatigue one. Meanwhile, the peak gluteus maximus force, peak gluteus medius force, peak tibialis posterior force, and peak gastrocnemius force significantly increased. There were no significant differences in the hip and knee joint flexion angles as well as the quadriceps and biceps femoris long head forces between the two groups., Conclusions: Mild fatigue can affect the performance of single leg landing, and players need to control the lower limbs by generating a higher muscle force to cope with the instability induced by fatigue. In a fatigued state, following initial contact with the ground, a decreased ankle dorsiflexion angle necessitates an increase in gastrocnemius and tibialis posterior muscle force to maintain stance during landing.

Despite the increase in research of hamstring stiffness through the use of ultrasound-based shear wave elastography, the active stiffness of biceps femoris long head (BFlh) and semitendinosus (ST) muscles under fatigue conditions at various contraction intensities has not been sufficiently explored. This study aimed to compare the effects of knee flexor's isometric contraction until exhaustion performed at 20% vs. 40% of maximal voluntary isometric contraction (MVIC), on the active stiffness responses of BFlh and ST. Eighteen recreationally active males performed two experimental sessions. The knee flexors' MVIC was assessed before the fatiguing task, which involved a submaximal isometric contraction until failure at 20% or 40% of MVIC. Active muscle stiffness of the BFlh and ST was assessed using shear wave elastography. BFlh active stiffness remained relatively unaltered at 20% of MVIC, while ST active stiffness decreased from ≅ 91% contraction time (55.79 to 44.52 kPa; p < 0.001). No intramuscular stiffness changes were noted in BFlh (36.02 to 41.36 kPa; p > 0.05) or ST (63.62 to 53.54 kPa; p > 0.05) at 40% of MVIC session. Intermuscular active stiffness at 20% of MVIC differed until 64% contraction time (p < 0.05) whereas, at 40% of MVIC, differences were observed until 33% contraction time (p < 0.05). BFlh/ST ratios were not different between intensities (20%=0.75 ± 0.24 ratio vs. 40%=0.72 ± 0.32 ratio; p > 0.05), but a steeper increase in BFlh/ST ratio was found for 20% (0.004 ± 0.003 ratio/%) compared to 40% (0.001 ± 0.003 ratio/%) of MVIC (p = 0.003). These results suggest that contraction duration could play a major role in inducing changes in hamstrings' mechanical properties during fatigue tasks compared to contraction intensity., (© 2024. The Author(s).)

Background: Sympathetic nervous system hyperactivity and chronic intermittent nocturnal hypoxia in individuals with obstructive sleep apnea (OSA) predispose them to microvascular impairment, which may contribute to increased daytime muscle fatigue. This study aimed to assess microvascular reactivity of the skeletal muscle, examine fatigability, and determine the relationship between fatigability and microvascular reactivity in adults with OSA., Methods: Twenty-six participants were allocated into two groups-those with OSA and those without i.e. non-OSA. Each group comprised of 13 individuals who underwent an arterial occlusion test on their non-dominant leg. The percentage change of maximal hyperemic response (MHR) and the time to achieve MHR (tM) of both the total myoglobin/hemoglobin (∆[Hbtot]) and the oxygenated myoglobin/hemoglobin (∆[HbO 2 ]) signals from near-infrared spectroscopy were calculated to examine microvascular reactivity. In addition, a 10-min walk test was performed to assess performance and perceived fatigability., Results: The OSA group demonstrated a reduced in ∆[Hbtot]MHR (150.9 ± 16.2% vs. 235.8 ± 72.7%, p = 0.006), ∆[HbO 2 ]MHR (131.4 ± 8% vs. 161.7 ± 10.6%, p = 0.001) and increased ∆[Hbtot]tM (80.5 ± 13.1 s vs. 47.7 ± 9.9 s, p < 0.001), ∆[HbO 2 ]tM (85.2 ± 22.4 s vs. 52.1 ± 5.9 s, p = 0.001) compared to the non-OSA group. In addition, participants in the OSA group experienced greater perceived (6 ± 1 vs. 2.8 ± 0.1, p = 0.001) and performance fatigability (1.1 ± 0.1 vs. 0.9 ± 0.1, p = 0.001) compared to adults in the non-OSA group. Moreover, both performance and perceived fatigability were significantly associated with microvascular reactivity parameters (all p < 0.05)., Conclusion: Microvascular dysfunction, as determined by an attenuated post-occlusive reactive hyperemia, is observed in individuals with OSA that may contribute to increased fatigability in these individuals., (© 2024. The Author(s).)

This study investigates the impact of quadriceps fatigue on lower limb biomechanics during the landing phase of a single-leg vertical jump (SLJ) in 25 amateur male basketball players from Ningbo University. Fatigue was induced through single-leg knee flexion and extension exercises until task failure. Kinematic and dynamic data were collected pre-fatigue (PRF) and post-fatigue (POF) using the Vicon motion capture system and the AMTI force platform and analyzed using an OpenSim musculoskeletal model. Paired sample t -tests revealed significant changes in knee and hip biomechanics under different fatigue conditions, with knee joint angle ( p < 0.001), velocity ( p = 0.006), moment ( p = 0.006), and power ( p = 0.036) showing significant alterations. Hip joint angle ( p = 0.002), moment ( p = 0.033), and power ( p < 0.001) also exhibited significant changes. Muscle activation and joint power were significantly higher in the POF condition, while joint stiffness was lower. These findings suggest that quadriceps fatigue leads to biomechanical adjustments in the knee and hip joints, which may increase the risk of injury despite aiding in landing stability.

Background: It is unclear whether chronically training close to volitional failure influences motor unit recruitment strategies during fatigue., Purpose: We compared resistance training to near volitional failure vs . non-failure on individual motor unit action potential amplitude (MUAP) and surface electromyographic excitation (sEMG) during fatiguing contractions., Methods: Nineteen resistance-trained adults (11 males, 8 females) underwent 5 weeks (3×/week) of either low repetitions-in-reserve (RIR; 0-1 RIR) or high RIR training (4-6 RIR). Before and after the intervention, participants performed isometric contractions of the knee extensors at 30% of maximal peak torque until exhaustion while vastus lateralis sEMG signals were recorded and later decomposed. MUAP and sEMG excitation for the vastus lateralis were quantified at the beginning, middle, and end of the fatigue assessment., Results: Both training groups improved time-to-task failure (mean change = 43.3 s, 24.0%), with no significant differences between low and high RIR training groups (low RIR = 28.7%, high RIR = 19.4%). Our fatigue assessment revealed reduced isometric torque steadiness and increased MUAP amplitude and sEMG excitation during the fatiguing task, but these changes were consistent between groups., Conclusion: Both low and high RIR training improved time-to-task failure, but resulted in comparable motor unit recruitment during fatiguing contractions. Our findings indicate that both low and high RIR training can be used to enhance fatiguability among previously resistance-trained adults., Competing Interests: The authors declare that they have no competing interests., (© 2024 Beausejour et al.)

Fatigue specifically affects the force production capacity of the working muscle, leading to a decline in athletes' performance. This study investigated the impact of fatigue on ankle flexor muscle activity and ground reaction forces (GRFs) in elite table tennis players, with a focus on the implications for performance and injury risk. Twelve elite male table tennis athletes participated in this study, undergoing a fatigue protocol that simulated intense gameplay conditions. Muscle activity of the soleus (SOL) and gastrocnemius lateralis (GL) muscles, heel height, and GRFs were measured using a combination of wireless electromyography (EMG), motion capture, and force plate systems. Results showed a significant decrease in muscle activity in both legs post-fatigue, with a more pronounced decline in the right leg. This decrease in muscle activity negatively affected ankle joint flexibility, limiting heel lift-off. Interestingly, the maximal anteroposterior GRF generated by the left leg increased in the post-fatigue phase, suggesting the use of compensatory strategies to maintain balance and performance. These findings underscore the importance of managing fatigue, addressing muscle imbalances, and improving ankle flexibility and strength to optimize performance and reduce the risk of injuries.

Objective. This study examined sex-related differences in fatigability and neuromuscular responses using surface electromyographic (sEMG) and mechanomyographic (sMMG) amplitude (AMP) and frequency (MPF) during fatiguing, maximal, bilateral isometric leg extensions. Approach. Twenty recreationally active males and females with resistance training experience performed continuous, maximal effort, bilateral isometric leg extensions until their force reduced by 50%. Linear mixed effect models analyzed patterns of force, sEMG, and sMMG AMP and MPF responses in the dominant limb. An independent samples t-test compared time-to-task failure (TTF) between sexes. Main Results. There were no significant differences in TTF between males and females. However, males experienced a greater rate of force loss compared to females. Furthermore, sEMG AMP and MPF and sMMG AMP responses followed similar linear trends for both sexes, while sMMG MPF showed non-linear responses with sex-dependent differences. Significance. These data suggest that although TTF was similar, males had a higher rate of force reduction, likely due to greater absolute strength. Furthermore, despite parallel changes in sEMG AMP and MPF, as well as sMMG AMP, the divergent responses observed in sMMG MPF highlight sex-dependent differences in how males and females experience changes in the firing rates of active motor units during sustained maximal contractions., (© 2024 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.)

Background: This study aimed to analyse the effects of a plank-based strength training programme on muscle activation in patients with long COVID., Subjects and Methods: Case series study that included patients with long COVID who participated in a 12-week trunk and pelvic muscle strength training programme. Clinical variables and the modified fatigue impact scale (MFIS) were used to assess fatigue levels. Percentage of muscle activation during a core muscle plank was measured via surface electromyography. Pre- and post-intervention results were compared using the Wilcoxon signed-rank test and evaluated with Cohen's D effect size (ES)., Results: Twenty-one subjects participated in the study; 81% female, mean age 47.5 years (range: 28-55 years), and median duration of symptoms 21 months (range: 5-24 months); 90.5% of the participants experienced fatigue (MFIS score = 38). Muscle activation during plank exercises improved across all muscles after the intervention, with significant increases in the left (p = 0.011, medium ES) and right external oblique (p =0.039, small ES) muscles and the right latissimus dorsi muscle (p = 0.039, small ES). Additionally, significant reductions in fatigue were observed in the total MFIS score (p = 0.004, medium ES) and in the physical (p < 0.001, large ES) and psychosocial subscales (p = 0.033, small ES)., Conclusions: Results suggest that a plank-based strength training programme may be effective in enhancing trunk and pelvic muscle activation in individuals with long COVID.

The primary aim of the study was to assess differences in strength performance, neuromuscular fatigue, and perceived exertion across phases of the menstrual cycle [MC; early follicular (eFP), late follicular (lFP), and mid-luteal phase (mLP)] and oral contraceptives [OCs; active pill phase (aPP) and nonactive pill phase (nPP)]. The secondary aim was to analyze the influence of fluctuating serum 17β-estradiol and progesterone concentrations on these parameters in naturally menstruating women. Thirty-four women (21 with a natural MC and 13 using OCs) completed three or two experimental sessions, respectively. Mean propulsive velocity (MPV mean ) and total number of repetitions (REP total ) were assessed during a power [3 × 8 at 60% 1RM (one-repetition maximum)] and hypertrophy squat loading (3 sets to failure at 70% 1RM), respectively. Changes in bench press and squat MPV at 60% 1RM in response to the loadings were used as surrogates for nonlocal and local fatigue, respectively. Total blood lactate accumulation (BLA A ) and markers of perceived exertion were assessed in each session. No significant differences between any of the MC or OC phases were observed for MPV mean , REP total , nonlocal and local fatigue, and markers of perceived exertion (all P > 0.050). A higher intraindividual 17β-estradiol concentration was significantly associated with a lower MPV mean ( P = 0.019). BLA A was significantly higher in the lFP than in the mLP ( P = 0.019) and negatively associated with the intraindividual progesterone concentration ( P = 0.005). Although 17β-estradiol may negatively influence the MPV, it appears that fluctuations of both sex hormones across the MC and OC phases are not prominent enough to induce significant or practically relevant changes in the assessed parameters. NEW & NOTEWORTHY Although a high intraindividual 17β-estradiol concentration was associated with a lower movement velocity, markers of strength performance and surrogates for nonlocal and local fatigue remained unaffected by MC and OC phases. Blood lactate accumulation was significantly reduced in the mLP. Furthermore, our findings suggest that the impact of the MC phases varies greatly among individuals. Individuals with high fluctuations in sex hormone concentrations may experience relevant changes in the assessed parameters.

Objective: This study aimed to investigate the effects of a head/neck supporting exoskeleton (HNSE) on the electromyographic fatigue threshold (EMG FT ) of the neck and shoulder muscles during a simulated overhead work task., Background: Overhead work is a well-known risk factor for neck and shoulder musculoskeletal disorders due to the excessive strain imposed on the muscles and joints in these regions., Method: Fourteen healthy males performed a repetitive overhead nut fastening/unfastening task to exhaustion while wearing and not wearing the HNSE at two neck extension angles (40% and 80% of neck maximum range of motion). Electromyographic signals were continuously recorded from the right and left sternocleidomastoid (SCMR, SCML), splenius capitis (SCR, SCL), upper trapezius (UTR, UTL), and anterior deltoid (ADR, ADL) muscles. The normalized electromyographic amplitude (nEMG) data was time normalized, and a bisegmental linear regression was applied to determine the muscle fatigue break point., Results: The results showed a significant increase in fatigue threshold time in the SCMR ( p < .001), SCML ( p = .002), and UTR ( p = .037) muscles when the HNSE was used. However, the EMG FT times for the right and left deltoid and left trapezius muscles showed a nonsignificant reduction due to the head/neck support exoskeleton use. In addition, the neck extension angle did not reveal a significant effect on muscles' EMG FT time., Conclusion: Overall, the findings confirmed a significant delay in fatigue onset in sternocleidomastoid muscles, as measured by the electromyographic fatigue threshold. This finding suggests that the HNSE can be an effective ergonomic intervention for reducing the risk of musculoskeletal disorders in overhead workers. However, further studies are needed to investigate the effect of the HNSE at other neck extension angles and more realistic tasks to ensure the generalizability of our results., Application: The present findings emphasize the application of the fatigue onset time to evaluate the effectiveness of ergonomic interventions, including exoskeletons, which can subsequently be utilized to alleviate postural demands and reduce the risk of musculoskeletal disorders.

Background: A deficit in neuromuscular trunk control can impact the lower limb motion, predisposing runners to injuries. This deficit may show a greater impact on runners with dynamic knee valgus. This study aimed to compare the effect of core fatigue on kinetic, kinematic, and electromyographic parameters of the trunk and lower limbs during single-leg drop landing between runners with and without dynamic knee valgus., Methods: Twenty-seven recreational runners were allocated to the valgus (n = 14) and non-valgus groups (n = 13). They performed the test before and after a fatigue protocol, taking a step forward and landing on the force platform while maintaining balance. The fatigue protocol included isometric and dynamic exercises performed consecutively until voluntary exhaustion. The vertical ground reaction force, the sagittal and frontal plane angles, and the electromyographic activity were evaluated. The integral of electromyographic activity was calculated into three movement phases. ANOVA with repeated measures was used to verify the group, time, and interaction effects., Results: After fatigue, both groups showed a significant reduction in the minimum (p = 0.01) and maximum (p = 0.02) knee angles in the frontal plane (more dynamic knee valgus) and greater gluteus medius activity (p = 0.05) from the peak of knee flexion to the end of the movement. The valgus group had a greater hip excursion (p = 0.01) and vertical linear shoulder displacement (p = 0.02) than the non-valgus., Conclusion: Our results suggest that core fatigue can impact the local muscle and the distal joint and that the groups presented different strategies to deal with the demand during landing., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Clinical Scenario: Following intense physical training, it is common for athletes to develop muscle soreness, muscle tightness and a sense of fatigue. Minimizing the time spent in this state is advantageous to limit time off from sport, potential injury and lack of mental focus., Clinical Question: Does dry needling aid in post-training recovery in athletes?, Summary of Key Findings: A search was performed for articles exploring the effect of dry needling on exercise/training recovery in athletes. Six articles were included in this critically appraised topic. Three articles were randomized controlled trials, one was a cross-over design, one was a case series, and one was a survey. Five of the six studies demonstrated that dry needling had some sort of positive effect on post-training recovery. One article found DN did not improve muscle soreness after a long distance race., Clinical Bottom Line: Based on six studies, DN provides mixed results on a variety of physiological and subjective measures. No adverse effects were reported with the use of DN on athletes following post-training., Strength of Recommendation: In agreement with the Center of Evidence-Based Medicine, the consistent results from three Level II and two Level III intervention studies designate that there is grade D evidence that DN may aid in some post-training recovery variables., Competing Interests: Declaration of competing interest We have no declarations of interest., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

We investigated the influence of anaerobic speed reserve (ASR) on post-activation performance enhancement (PAPE). Twenty-two endurance runners and triathletes were evaluated for maximum sprinting speed (MSS) and countermovement jump (CMJ) before (non-fatigued) and after (fatigued) an incremental running test. They were allocated in LASR (low-ASR) and HASR (high-ASR) groups for comparisons between conditions. HASR showed greater CMJ and MSS (both p  ≤ 0.005) performances, with enhanced CMJ in fatigued condition ( p  ≤ 0.008). Significant correlations were found between ASR, CMJ, and MSS in both conditions ( p  ≤ 0.01) for the entire sample, and between ∆CMJ and ∆MSS ( p  ≤ 0.001) in LASR. Our results show that ASR profile influences PAPE., Competing Interests: The authors declare there are no competing interests.

The aim of the study was to assess the impact of aging on neuromuscular fatigue and recovery. Ten young (23.08 ± 1.43 years) and older (61.19 ± 1.80 years) males performed an intermittent maximal isometric exercise with the knee extensors followed by 27 min of recovery. Maximal voluntary contraction (MVC), total work (W'), voluntary activation (VA), potentiated resting twitch (Ptw), and electromyography (EMG) were recorded and then analyzed. Peripheral and central fatigue following exercise were lower in old compared to young (- 29.99% vs.  - 42.68% and  - 14.55 vs.  - 20.02%; P < 0.05, respectively). Despite old performing 50% less work, RMS/M max reduction was similar between old and young (- 26.46% vs.  - 29.93%; P > 0.05, respectively). During the recovery period, our results showed that recovery of the MVC was impaired for old (14.93% for old vs. 30.66% for young) and still incomplete until 27 min.VA increased significantly compared to post exercise after 1 min only for young (P = 0.001), potentially affecting the recovery pattern of MVC during the early phase due to their significant correlation (r 2  = 0.58, P = 0.01). Peripheral fatigue recovery was also lower for old (11.18% vs. 18.72%; P < 0.001), and both groups failed to recover their baseline value (both P < 0.005). The lower peripheral and central fatigue observed in elderly following exercise appears for the first instance as a fatigue resistance. However, the delayed neuromuscular recovery reveals instead a reduced fatigue tolerance reflecting age-related alteration within contractile properties and/or within central nervous system., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Background: In general, it has been suggested that females are more fatigue-resistant than males, with the magnitude of difference being most pronounced during low-intensity sustained contractions. However, the mechanisms for the apparent sex difference have not yet been fully elucidated in the literature. This study aimed to examine sex-related differences in fatigability and patterns of neuromuscular responses for surface electromyographic (sEMG) and mechanomyographic (sMMG) amplitude and frequency (MPF) characteristics during a sustained submaximal bilateral, isometric leg extension muscle action., Methods: A sample of 20 young recreationally active males and females with previous resistance training experience performed a sustained, submaximal, bilateral isometric leg extension until task failure. Time-to-task failure was compared using a nonparametric bootstrap of the 95% confidence interval for the mean difference between males and females. Additionally, patterns of response for sEMG and sMMG amplitude and MPF of the dominant limb were examined using linear mixed effect models., Results: There were no differences in time-to-task failure between males and females. Additionally, neuromuscular responses revealed similar patterns of responses between males and females. Interestingly, sEMG amplitude and sMMG amplitude and MPF all revealed non-linear responses, while sEMG MPF demonstrated linear responses., Conclusion: These data revealed that time-to-task failure was not different between males and females during sustained submaximal bilateral, isometric leg extension. Interestingly, the parallel, non-linear, increases in sEMG and sMMG amplitude may indicate fatigue induced increases in motor unit recruitment, while the parallel decreases in sMMG MPF may be explained by the intrinsic properties of later recruited motor units, which may have inherently lower firing rates than those recruited earlier., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

We examined the sensitivity and time-course of recovery of neuromuscular and perceptual player monitoring measures to U-18 English Premier League academy football match play. Eighteen players performed maximal posterior chain, hip adductor and abductor isometric strength tests, countermovement jumps (CMJ) and provided self-report wellbeing scores around eight competitive league home games: 1 day before (MD-1), pre-match (MD-PRE), post-match (MD-POST) and two (MD+2) and three (MD+3) days post-match. A permutational multivariate analysis of variance and post hoc univariate analyses of variance were used to examine match-induced responses to monitoring variables. Between MD-1 and MD-POST, we observed small to moderate reductions to the adductor and abductor peak force and maximal impulse and IPCS peak force; small reductions to CMJ jump height (JH) (flight time), eccentric peak force and eccentric deceleration rate of force development and moderate to large reductions to perceived fatigue, muscle soreness and mood. No match-induced changes were observed for CMJ flight time: contraction time or eccentric duration. Posterior chain, abductor, CMJ and self-report measures normalised by MD+3 but adductor peak force remained compromised at MD+3 (ES = small). Posterior chain, adductor and abductor peak isometric force and maximal impulse; CMJ JH, eccentric peak force and eccentric deceleration rate of force development and perceived fatigue, muscle soreness and mood are sensitive to match-induced fatigue. Since adductor peak force remained compromised at MD+3, it is apparent that players might not achieve complete neuromuscular recovery within 3 days of match play, and that the adductor muscle group might be particularly vulnerable to match-induced fatigue., (© 2024 The Author(s). European Journal of Sport Science published by Wiley‐VCH GmbH on behalf of European College of Sport Science.)

In giant slalom, the ability to apply a high amount of force in the radial direction is essential for performance. A race is characterized by repeated turns performed at high velocity, potentially inducing fatigue. Therefore, this study aimed to assess the effect of fatigue on performance, trajectory characteristics, and force production capacities onto the snow. Twelve skiers ran a 4-turn section with (FATIGUE) and without pre-induced fatigue (CONTROL). Knee extensor maximal voluntary contraction (MVC) was performed before the experiment and after both conditions. Section time, energy dissipation, path length, total force output, force application effectiveness, and EMG activity of the main lower-limb muscles were compared between conditions. Multiple linear regressions were used to understand whether interindividual variability in the kinematic, kinetic and EMG between conditions explains variability in performance changes with fatigue. MVC was lower after FATIGUE (-19.1 ± 6.4%, p  < 0.001) but did not change after CONTROL. FATIGUE was associated with longer section times (+0.21 ± 0.11 s, p  < 0.001), energy dissipation (-0.78 ± 1.05 J.s.kg.m -1 , p  = 0.026), path length (+1.1 ± 1.6 m, p  = 0.033) and lower force application effectiveness (-0.1 ± 0.1, p  = 0.017). This study experimentally demonstrates that fatigue in giant slalom results in lower force application effectiveness, inducing over-dissipation of mechanical energy and longer path length, leading to lower performance.

Achilles tendinopathy is prevalent among Irish dancers, believed to be due to aesthetic technical requirements and high-impact landing tasks. However, the peak Achilles tendon force during Irish dancing-specific landing tasks has not been quantified. Furthermore, the influence of fatigue is unclear. This study aimed to quantify the peak Achilles tendon force during three common Irish dancing landing tasks and investigate the effects of fatigue on this force. Twelve nationally competitive Irish dancers completed the landing tasks prior to and following a fatigue protocol. A Vicon motion analysis system and AMTI force plates were used to calculate sagittal plane ankle joint kinematics during landing to estimate peak Achilles tendon force. Three independent measures (Rating-of-Fatigue scale, Flight time: Contraction during a counter movement jump and jump height during the landing trials) were used to evaluate participant fatigue between conditions. Results revealed a significant difference in peak Achilles tendon force between the three landing tasks, however, no significant difference was observed between pre- and post-fatigue. Further research is required to investigate the effects of the landing technique used in Irish Dancing on peak Achilles tendon force with the aim to reduce peak Achilles tendon force and the risk of developing Achilles tendinopathy.

The overall objective was to determine how no extracellular glucose and/or low glycogen content affect fatigue kinetics in mouse flexor digitorum brevis (FDB) single muscle fibers. High glycogen content (Hi GLY), near normal in situ level, was obtained by incubating fibers in culture medium containing glucose and insulin while low glycogen content (Lo GLY), at about 19% of normal in situ level, was achieved by incubating fibers without glucose. Neither Lo GLY nor the absence of extracellular glucose (0GLU) affected tetanic [Ca 2+ ] i prior to fatigue. The number of contracting unfatigued fibers versus stimulus strength relationship of Lo GLY-0GLU fibers was shifted to higher voltages compared to Hi GLY fibers exposed to 5.5 mM glucose (5GLU). The relationship for Lo GLY-0GLU fibers was shifted back toward that of Hi GLY-5GLU fibers when glucose was reintroduced, whereas the removal of glucose from Hi GLY-5GLU fibers had no effect. Fatigue was elicited with one 200 ms long tetanic contraction every s for 3 min. Both Lo GLY and 0GLU increased the rate at which intracellular tetanic concentration ([Ca 2+ ] i ) declined and unstimulated [Ca 2+ ] i increased during fatigue in the order of the least fatigue resistant > mid fatigue resistant > the most fatigue resistant fibers., (© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)

Introduction: The aim was to compare the fatiguing effects induced by continuous (CONT) and intermittent (INT) tasks of an identical duration by equating the force-time integral., Method: ː Fourteen men performed two sequences (4 blocks of 378s) of contractions (CONT or INT) of the quadriceps femoris. The CONT contraction of 378s corresponded to 10% of the maximum voluntary muscle contraction (MVC). The INT 3s contractions corresponded to 70% of the MVC, separated by rest periods of 18s (a 21s cycle) and repeated 18 times (21s x 18) for 378s. Hence, the force-time integral was identical for the both contraction tasks (378s × 10% MVC = 37.8; 3s x 18 repetitions x 70% MVC = 37.8)., Results: ː The MVC and central activation ratio were measured before, during and after the sequence of muscle contractions. For a same force-time integral done during an identical duration of activity, the CONT contractions engendered earlier and greater decrease in motor output and voluntary activation than the INT contractions., Conclusion: Continuous muscle actions are more fatiguing than intermittent muscle actions. They could therefore be relevant to develop resistance to muscle fatigue but would be not suitable for undertaking long or sustained workloads., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

The study investigated the effects of unilateral and bilateral lower extremity fatigue on both postural stability and postural adjustments. Fourteen young male subjects performed unilateral and bilateral dynamic lower extremity pedaling exercises with 5 sets of 20 times at 50 % maximum voluntary contraction. Center of pressure (COP) signals were recorded before and after the fatigue exercise. Electromyography activities of six trunk and leg muscles were recorded and analyzed during the anticipatory (APAs) and compensatory (CPAs) postural adjustments. The results showed that both fatiguing exercises caused an increase in COP and larger APAs and CPAs in the rectus femoris and tibialis anterior during externally initiated perturbation. However, the observed indicators showed no clear difference between unilateral and bilateral fatigue. These results validated that when enlarged APAs were not sufficient to resist the external perturbation, the central nervous system increased the strength of CPAs to maintain the stability of the body. These findings provided a perspective on the association between APAs and CPAs, which may apply to the athletic training or rehabilitation on postural control., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Background: The present study aimed to investigate whether head and neck cooling (at 18 °C next to the skin) and fatiguing submaximal exercise at a thermoneutral ambient temperature can induce peripheral and central responses in healthy men and those with multiple sclerosis (MS)., Methods: A local head-neck cooling (at 18 °C next to the skin) intervention in men with a relapsing-remitting form of MS (n = 18; age 30.9 ± 8.1 years) and healthy men (n = 22; age 26.7 ± 5.9 years) was assessed. Men in both groups performed 100 intermittent isometric knee extensions with 5 s contractions and 20 s of rest. The primary variables were measured before exercise, after 50 and 100 repetitions, and 1 h after recovery. The central activation ratio, maximal voluntary contraction, electrically induced force, electromyography, contractile properties, blood markers, muscle temperature, and perception of effort were measured., Results: Compared with noncooled conditions, head and neck cooling increased the central capacity to activate exercising muscles but resulted in greater exercise-induced peripheral fatigue in men with MS (p < 0.05). Local cooling did not affect motor accuracy or the amplitude of electromyography signals; however, these factors were related to the intensity of the motor task (p > 0.05). The changes in central and peripheral fatigability induced by local cooling during submaximal exercise were more pronounced in men with MS than in healthy men (p < 0.05)., Conclusion: Head and neck cooling enhances central activation of muscles during exercise, leading to improved exercise performance compared with noncooled conditions in men with MS., Competing Interests: Declaration of competing interest The authors declare that they have no competing interests., (Copyright © 2024 Elsevier B.V. All rights reserved.)

The aim of this study was to examine the acute metabolic response, neuromuscular activity, and mechanical performance of different set configurations in bench-press (BP). Twenty-two resistance-trained men performed three resistance exercise protocols consisting of 3 x 12 BP repetitions at 60% 1RM, with 4 minutes of rest between sets, but with different set configurations: (a) traditional set (TS), without rest within the set; (b) cluster-6 (CS6), with 30-second intraset rest after the sixth repetition in each set; and (c) cluster-2 (CS2), with 30-second intraset rest every two repetitions. Mean propulsive force (MPF), velocity (MPV), power (MPP), and electromyography (EMG) values were recorded for each repetition. Blood lactate, maximal voluntary isometric BP contraction, and dynamic strength in BP were assessed pre- and post-exercise. The CS2 protocol resulted in greater mechanical performance (i. e. MPF, MPV, and MPP) and lower alterations of EMG parameters (i. e. root mean square and median frequency) during the exercise compared to CS6 and TS (TS

We explored the feasibility of utilizing immediate changes in flight time-based vertical countermovement jump height as an on-field measure for fatigue-induced decrements in performance. Comparing Inertial Measurement Units (IMUs) worn at five body locations (feet, shorts for thighs and pelvis, waist strap, and thorax in a standard GPS vest) with a force plate as a reference, we enlisted 19 amateur football players who performed a series of 10 maximal 30 m sprints (initiated every minute). Maximal jumps were executed immediately before and after each sprint, with the latter jumps recorded on a force plate integrated into the field. Bland Altman's bias (-0.49 cm) and limits of agreement (1.01 cm) were minimal for the feet IMUs. The thorax IMU had the highest bias (-6.35 cm), but the limits of agreement (2.73 cm) were similar to the other locations. Repeated measures correlations (rmcorr) between force plate and IMUs were excellent for the feet (rmcorr = 0.98) and good for the thorax (rmcorr = 0.86) and other locations except for the waist strap. In the fatigued state, within-session coefficients of variation ranged from 4.0% (pelvis in shorts) to 6.5% (waist strap). These findings suggest that body-worn IMUs possess the potential for a prompt and straightforward on-field vertical jump assessment to monitor acute fatigue.

When fatigued, the wrist extensors, which are the primary wrist stabilizers, impair distal upper limb motor performance in a surprisingly similar way as when fatiguing the wrist flexors. It is possible that the wrist extensors are so active as antagonists that they develop an equal degree of fatigue during wrist flexion contractions, making it difficult to truly isolate their impact on performance. Thus, the purpose of this study was to examine how wrist flexion/extension forces are impaired following either agonist or antagonist sustained submaximal wrist contractions. 13 male participants attended four laboratory sessions. In these sessions, fatigue was induced via a sustained submaximal isometric contraction of either wrist flexion or extension. These contractions were held for up to 10 min at 20% of the participant's baseline maximal voluntary contraction (MVC) force. Throughout the sustained contraction, intermittent agonist (matching the sustained contraction) or antagonist (opposing the sustained contraction) MVCs were performed. Unsurprisingly, agonist MVC forces decreased significantly more than antagonist (Agonist: 58.5%, Antagonist: 86.5% of MVC, P < 0.001). However, while there were no differences in antagonist wrist extension and flexion MVC decreases (Wrist Flexion: 87.5%, Wrist Extension: 85.5%, P = 0.41), wrist extension MVCs did decrease significantly more than wrist flexion MVCs when forces were expressed relative to the agonist (P = 0.036). These findings partially support the hypothesis that the wrist extensors may be more susceptible to developing fatigue when functioning as antagonists than the wrist flexors. This work will help equip future research into the motor control of the upper limb and the prevention of forearm-related musculoskeletal disorders., Competing Interests: Declaration of competing interest None., (Crown Copyright © 2024. Published by Elsevier B.V. All rights reserved.)

Emerging research suggests that muscular and kinematic responses to overhead work display a high degree of variability in fatigue-related muscular and kinematics changes, both between and within individuals when evaluated across separate days. This study examined whether electromyographic (EMG), kinematic, and kinetic responses to an overhead drilling task performed until volitional fatigue were comparable to those of a repeated identical exposure of the task completed 1 week later. Surface EMG and intramuscular EMG, sampled from 7 shoulder muscles, and right upper limb kinematics and kinetics were analyzed from 15 male and 14 female participants. No significant day-to-day changes in EMG mean power frequency (MPF) were observed, though serratus anterior displayed significantly less fatigue-related increase in EMG root-mean-squared (RMS) signal amplitude on day 2. Unfatigued upper kinematics on day 2 featured an increase in thoracohumeral elevation, elbow flexion, and decrease in wrist ulnar deviation compared to unfatigued state on day 1. Fatigue-related changes in shoulder joint flexion moment that were present on day 1 were reduced on day 2, suggesting that a more efficient overhead work strategy was learned and preserved across successive days. Day-to-day changes in upper limb joint angle variability, quantified by median absolute deviation (MdAD), were joint dependent. Despite yielding a variable fatigue-related kinetic strategy on both days, kinematic and kinetic fatigue-related changes on a second day of completing an overhead drilling task suggested a potential kinematic learning effect., Competing Interests: Declaration of competing interest None., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Introduction: Muscle fatigue is considered a risk factor for hamstring injury (HSI), which occurs during high-speed running. To decrease this risk, higher gluteal muscle activity may have a role to play. This study aimed to compare the muscle activities of the gluteus maximus (GMax) and hamstring (HS) muscles between HSI-experienced and inexperienced people in pre- and post-fatigue conditions during the swing and stance phases of running., Methods: Participants were asked to run 13 sets of 20 km/h on the treadmill. GMax and HS muscle activities of the (i) injured and (ii) uninjured legs in the HSI-experienced group and (iii) dominant leg (healthy leg) in the inexperienced group were collected using the first run as pre-fatigue data, and the last (13th) run as post-fatigue data., Results: GMax activity of the injured legs was higher than in the healthy leg during the stance phase in pre-fatigue condition (p < 0.05). The activity of the GMax and semitendinosus were higher in the uninjured legs than in the healthy legs during the swing phase in pre-fatigue condition (p < 0.05). However, no differences in muscle activities between pre- and post-fatigue or the injured and uninjured legs were found., Conclusion: The GMax may prevent HSI recurrence during the stance phase of running. The GMax and semitendinosus of the uninjured leg may act as stabilizers of the body while the injured leg is placed on the ground., Competing Interests: Declaration of competing interest None declared., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

This study presents a novel method for evaluating the submaximal velocity-force (V(F)) relationship in mountain ultramarathon races using crowdsourced data from Strava.com. The dataset includes positional data from 408 participants of the 171-km UTMB® 2023 race (9,850-m D+). The race was divided into 100-m segments. The mean net propulsive force and velocity were computed for each segment to describe the submaximal V(F) relationship as a rational function of three parameters. F 1 : propulsive force at 1 m · s -1 ; V 0 : theoretical maximum velocity on flat terrain; C: curvature parameter (the lower C, the more linear the V(F) relationship). The V(F) profile parameters were found to be F 1  = 1.80 ± 0.33 N · kg -1 , V 0  = 2.36 ± 0.42 m · s -1 , and C = 0.66 ± 1.81, with good independence between the parameters within a group of homogeneous performance. The best athletes had the highest F 1 , V 0 , and C values. V(F) parameters were affected by fatigue during the race, with decreases of 20.9%, 32.0%, and 59.8% between the first and second parts of the race respectively. These findings suggest that the V(F) relationship is an interesting original approach for studying performance and fatigability during mountain ultra-endurance races.

Neck pain associated with helmet-wear is an occupational health problem often observed in helicopter pilots and aircrew. Whether aircrew helmet wearing is associated with physiological and biomechanical differences between sexes is currently unknown. This study investigated neuromuscular activation patterns during different helmet-wearing conditions. The helmet load was manipulated through a novel Helmet Balancing System (HBS) in healthy, non-pilot male and female participants (n = 10 each, age 19-45 years) in two phases. Phase A assessed the acute effects of helmet-wear on neck muscles activation during head movements. Phase B examined changes in muscle activity and cervical disc height after wearing a helmet for 45 min. In Phase A, muscle activity was similar between sexes in many movements, but it was higher in female participants when wearing a helmet than in males. The HBS reduced muscle activity in both sexes. In Phase B, female participants exhibited a greater level of muscular fatigue, and male participants' cervical disc height was significantly decreased [5.7 (1.4) vs. 4.4 (1.5) mm, P < 0.001] after continuous wearing. Both sexes showed no significant change in muscle fatigue and disc height [male: 5.0 (1.3) vs. 5.2 (1.4) mm, P = 0.604] after applying HBS. These findings demonstrate sex-specific physiological and biomechanical responses to wearing a helmet. They may indicate different postural and motor control strategies, associated with different neck pain aetiologies in male and female aircrew, the knowledge of which is important to reduce or prevent musculoskeletal injuries associated with helmet wearing., (© 2024 The Author(s). Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.)

Skeletal muscle fibers need to have mechanisms to decrease energy consumption during intense physical exercise to avoid devastatingly low ATP levels, with the formation of rigor cross bridges and defective ion pumping. These protective mechanisms inevitably lead to declining contractile function in response to intense exercise, characterizing fatigue. Through our work, we have gained insights into cellular and molecular mechanisms underlying the decline in contractile function during acute fatigue. Key mechanistic insights have been gained from studies performed on intact and skinned single muscle fibers and more recently from studies performed and single myosin molecules. Studies on intact single fibers revealed several mechanisms of impaired sarcoplasmic reticulum Ca 2+ release and experiments on single myosin molecules provide direct evidence of how putative agents of fatigue impact myosin's ability to generate force and motion. We conclude that changes in metabolites due to an increased dependency on anaerobic metabolism (e.g., accumulation of inorganic phosphate ions and H + ) act to directly and indirectly (via decreased Ca 2+ activation) inhibit myosin's force and motion-generating capacity. These insights into the acute mechanisms of fatigue may help improve endurance training strategies and reveal potential targets for therapies to attenuate fatigue in chronic diseases.

Introduction: Quadriceps femoris muscle (QFM) fatigue has a detrimental impact on athlete performance. Therefore, it is crucial to evaluate various performance parameters under fatigued conditions. This study aimed to assess the performance of the QFM during both concentric and eccentric contractions before and after fatigue in the lower extremities of healthy amateur soccer players., Method: Twenty-four healthy amateur soccer players performed three consecutive knee extension and flexion movements concentrically and eccentrically at a velocity of 120°/s with maximum effort, using a Biodex dynamometer. Fatigue was induced by a protocol involving repetitive concentric knee extension and flexion movements at 120°/s, with a load of 50% of maximal voluntary isometric contraction (MVIC) of the QFM until its moment declined to 50% of MVIC. Separate 2-way analyses of variance were conducted to assess the influence of contraction and fatigue on various isokinetic parameters., Results: No significant interaction effect between contraction and fatigue was observed for any of the parameters. There was a significant main effect of fatigue on average power for both lower extremities. However, no significant main effect of fatigue was observed for normalized peak moment, angle of peak moment, moment at 0.2s, total work, acceleration, and deceleration times. In contrast, significant main effects of contraction were noted for normalized peak moment, moment at 0.2s, average power, acceleration, and deceleration times in both lower extremities., Conclusion: Average power appeared as the most sensitive performance parameter to fatigue. To enhance QFM performance, emphasizing eccentric exercises during training and conditioning programs could be beneficial for athletes., Competing Interests: Declaration of competing interest None., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Fatigue of temporomandibular joint (TMJ) tissues reflects the effects of magnitude (energy density; ED) and frequency of loading (jaw muscle duty factor; DF). This observational study measured these variables and tested for differences in mechanobehavior scores (MBS = ED 2 × DF) and component variables in subjects with and without TMJ disc displacement (±D). In accordance with Institutional Review Board and STROBE guidelines, written informed consent was obtained, and examination and imaging protocols identified eligible adult subjects. Specifically, magnetic resonance imaging was used to assign subjects' TMJs to ±D groups. Subjects were trained to record in-field jaw muscle activities, from which DFs (percentage of recording time) were determined. EDs (mJ/mm 3 ) were estimated using modeled TMJ loads and in vivo dynamic stereometry. Multivariate analysis of variance, post hoc independent t tests, and K-means cluster analysis identified significant group differences ( P < 0.05). Of 242 individuals screened, 65 females (TMJs: 78 +D, 52 -D) and 53 males (TMJs: 39 +D, 67 -D) participated. Subjects produced 312 daytime and 319 nighttime recordings of average duration 6.0 ± 0.2 h and 7.6 ± 0.1 h, respectively, and 219 (114 right, 105 left) intact dynamic stereometry recordings. Average EDs were 2-fold and significantly larger in +D than -D TMJs ( P < 0.0001). DFs were on average 3-fold larger during the daytime versus nighttime for both masseter and temporalis muscles and 1.8- and 3.0-fold larger for the masseter versus temporalis muscle during the daytime and nighttime, respectively. Daytime masseter MBSs for +D TMJs in females were the largest overall at 621 ± 212 (mJ/mm 3 ) 2 % and 2- to 43-fold larger versus -D TMJs in both sexes during daytime and nighttime. Cluster analysis ( P < 0.0001) identified groups 2 and 3, which comprised 87% +D TMJs and had average MBSs 21-fold larger than group 1. The results show MBS as a potential biomarker to predict homeostasis versus progression or reversal of degenerative TMJ structural changes., Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

This study aimed to utilize the nonnegative matrix factorization (NNMF) algorithm for muscle synergy analysis, extracting synergy structures and muscle weightings and mining biomarkers reflecting changes in muscle fatigue from these synergy structures. A leg press exercise to induce fatigue was performed by 11 participants. Surface electromyography (sEMG) data from seven muscles, electrocardiography (ECG) data, Borg CR-10 scale scores, and the z-axis acceleration of the weight block were simultaneously collected. Three indices were derived from the synergy structures: activation phase difference, coactivation area, and coactivation time. The indicators were further validated for single-leg landing. Differences in heart rate (HR) and heart rate variability (HRV) were observed across different fatigue levels, with varying degrees of disparity. The median frequency (MDF) exhibited a consistent decline in the primary working muscle groups. Significant differences were noted in activation phase difference, coactivation area, and coactivation time before and after fatigue onset. Moreover, a significant correlation was found between the activation phase difference and the coactivation area with fatigue intensity. The further application of single-leg landing demonstrated the effectiveness of the coactivation area. These indices can serve as biomarkers reflecting simultaneous alterations in the central nervous system and muscle activity post-exertion., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Textile-based surface electromyography (sEMG) electrodes have emerged as a prominent tool in muscle fatigue assessment, marking a significant shift toward innovative, noninvasive methods. This review examines the transition from metallic fibers to novel conductive polymers, elastomers, and advanced material-based electrodes, reflecting on the rapid evolution of materials in sEMG sensor technology. It highlights the pivotal role of materials science in enhancing sensor adaptability, signal accuracy, and longevity, crucial for practical applications in health monitoring, while examining the balance of clinical precision with user comfort. Additionally, it maps the global sEMG research landscape of diverse regional contributors and their impact on technological progress, focusing on the integration of Eastern manufacturing prowess with Western technological innovations and exploring both the opportunities and challenges in this global synergy. The integration of such textile-based sEMG innovations with artificial intelligence, nanotechnology, energy harvesting, and IoT connectivity is also anticipated as future prospects. Such advancements are poised to revolutionize personalized preventive healthcare. As the exploration of textile-based sEMG electrodes continues, the transformative potential not only promises to revolutionize integrated wellness and preventive healthcare but also signifies a seamless transition from laboratory innovations to real-world applications in sports medicine, envisioning the future of truly wearable material technologies.

Background: The handstand is an essential skill in acrobatic sports. This skill requires the athlete to maintain an inverted upright stance with only the hands supported, which requires a great effort of muscular coordination and motor control. Several factors influence the ability to control the posture, including fatigue, which is a bit studied constraint of handstand performance., Research Question: With the aim to find out whether variability in movement control can be an indicator of fatigue, the present study was carried out., Method: Fourteen male acrobatic gymnasts were required to perform handstands. The time series for analyzing variability were capturing using Force Platforms, which is a traditional laboratory instrument, and Inertial Measurement Units (IMU), which is a more recent and less widely used, but more accessible tool. For this purpose, an analysis of the amount of variability was carried out, using the standard deviation. And analysis of the structure of variability (or complexity), using Detrended Fluctuation Analysis (DFA) and Fuzzy Entropy (FuEn)., Results: Our results reveal that fatigue causes significant increases in the amount of variability in the medio-lateral axis on the force platform, and in the IMU located in the area of the L5 vertebra. These changes are accompanied by increased auto-correlation in the medio-lateral axis of the force platform, and more unpredictable behavior in the L5 IMU., (© 2024. The Author(s).)

Although it is clear that the bioenergetic basis of skeletal muscle fatigue (transient decrease in peak torque or power in response to contraction) involves intramyocellular acidosis (decreased pH) and accumulation of inorganic phosphate (Pi) in response to the increased energy demand of contractions, the effects of old age on the build-up of these metabolites has not been evaluated systematically. The purpose of this study was to compare pH and [Pi] in young (18-45 yr) and older (55+ yr) human skeletal muscle in vivo at the end of standardized contraction protocols. Full study details were prospectively registered on PROSPERO (CRD42022348972). PubMed, Web of Science, and SPORTDiscus databases were systematically searched and returned 12 articles that fit the inclusion criteria for the meta-analysis. Participant characteristics, contraction mode (isometric, dynamic), and final pH and [Pi] were extracted. A random-effects model was used to calculate the mean difference (MD) and 95% confidence interval (CI) for pH and [Pi] across age groups. A subgroup analysis for contraction mode was also performed. Young muscle acidified more than older muscle (MD = -0.12 pH; 95%CI = -0.18,-0.06; p<0.01). There was no overall difference by age in final [Pi] (MD = 2.14 mM; 95%CI = -0.29,4.57; p = 0.08), although sensitivity analysis revealed that removing one study resulted in greater [Pi] in young than older muscle (MD = 3.24 mM; 95%CI = 1.72,4.76; p<0.01). Contraction mode moderated these effects (p = 0.02) such that young muscle acidified (MD = -0.19 pH; 95%CI = -0.27,-0.11; p<0.01) and accumulated Pi (MD = 4.69 mM; 95%CI = 2.79,6.59; p<0.01) more than older muscle during isometric, but not dynamic, contractions. The smaller energetic perturbation in older muscle indicated by these analyses is consistent with its relatively greater use of oxidative energy production. During dynamic contractions, elimination of this greater reliance on oxidative energy production and consequently lower metabolite accumulations in older muscle may be important for understanding task-specific, age-related differences in fatigue., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Arieta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

The quadriceps are particularly susceptible to fatigue during repetitive lifting, lowering, and carrying (LLC), affecting worker performance, posture, and ultimately lower-back injury risk. Although robotic exoskeletons have been developed and optimized for specific use cases like lifting-lowering, their controllers lack the versatility or customizability to target critical muscles across many fatiguing tasks. Here, we present a task-adaptive knee exoskeleton controller that automatically modulates virtual springs, dampers, and gravity and inertia compensation to assist squatting, level walking, and ramp and stairs ascent/descent. Unlike end-to-end neural networks, the controller is composed of predictable, bounded components with interpretable parameters that are amenable to data-driven optimization for biomimetic assistance and subsequent application-specific tuning, for example, maximizing quadriceps assistance over multiterrain LLC. When deployed on a backdrivable knee exoskeleton, the assistance torques holistically reduced quadriceps effort across multiterrain LLC tasks (significantly except for level walking) in 10 human users without user-specific calibration. The exoskeleton also significantly improved fatigue-induced deficits in time-based performance and posture during repetitive lifting-lowering. Last, the system facilitated seamless task transitions and garnered a high effectiveness rating postfatigue over a multiterrain circuit. These findings indicate that this versatile control framework can target critical muscles across multiple tasks, specifically mitigating quadriceps fatigue and its deleterious effects.

Forecasting can be utilized to predict future trends in physiological demands, which can be beneficial for developing effective interventions. This study implemented forecasting models to predict fatigue level progression when performing exoskeleton (EXO)-assisted tasks. Specifically, perceived and muscle activity data were utilized from nine recruited participants who performed 45° trunk flexion tasks intermittently with and without assistance until they reached medium-high exertion in the low-back region. Two forecasting algorithms, Autoregressive Integrated Moving Average (ARIMA) and Facebook Prophet, were implemented using perceived fatigue levels alone, and with external features of low-back muscle activity. Findings showed that univariate models without external features performed better with the Prophet model having the lowest mean (SD) of root mean squared error (RMSE) across participants of 0.62 (0.24) and 0.67 (0.29) with and without EXO-assisted tasks, respectively. Temporal effects of BSIE on delaying fatigue progression were then evaluated by forecasting back fatigue up to 20 trials. The slope of fatigue progression for 20 trials without assistance was ~48-52% higher vs. with assistance. Median benefits of 54% and 43% were observed for ARIMA (with external features) and Prophet algorithms, respectively. This study demonstrates some potential applications for forecasting models for workforce health monitoring, intervention assessment, and injury prevention.

Purpose: This pilot study investigated the functional outcomes after ischemic preconditioning (IPC) in high-level para-athletes with spinal-cord injury., Methods: Nine athletes completed 2 handgrip exercise trials (an isometric hold to failure at 60% maximal voluntary contraction [ISO] and a progressive, intermittent handgrip to failure [INT]), preceded by either IPC (220 mm Hg) or sham (20 mm Hg) for six 5-minute periods, in a repeated-measures, crossover design., Results: Although small performance improvements in time to task failure were observed in the ISO (∼5%) and INT (∼8%) IPC conditions, which are similar to those reported elsewhere, no statistical influence was observed (ISO-IPC, 74.2 [32.6] s; SHAM, 70.7 [27.2] s; P = .73; INT-IPC, 426.0 [80.1] s; SHAM, 392.2 [42.5] s; P = .35). Fatigue was evident in the forearm muscle force (maximal voluntary contraction) ISO (mean decline of 178.1 [76.0] N [95% CI, -10.4 to 366.7 N]; P < .05) and INT (mean decline of 182.2 [72.5] N [95% CI, 34.5-329.8 N]; P < .05) trials but not different between treatments (P > .95)., Conclusions: Although small performance improvements in time to task failure were observed, the findings of the present data set suggest that acute bouts of IPC do not meaningfully influence fatigue during handgrip exercise in para-athletes with spinal-cord injury.

Purpose: To examine the reproducibility and sensitivity of a self-paced field running test (SFT) in monitoring positive and negative changes in endurance performance., Methods: A total of 27 (11 women) recreational runners participated in a 6-week training intervention. The intervention was divided into a 3-week baseline period, a 2-week overload period, and a 1-week recovery period. An incremental treadmill test was performed before the baseline period and a 3000-m running test before and after all periods (T1-T4). In addition, the participants performed once a week an SFT (SFT1-6), which consisted of submaximal (6 + 6 + 3-min test at perceived exertion of 9/20, 13/20, and 17/20) and maximal sections (6 × 3-min intervals at maximum sustainable effort). The associations between the incremental treadmill test and the SFT1 performance were examined with the Pearson correlation, and the intraclass correlation was analyzed for the parameters of SFT1 to SFT3 sessions during the baseline period. The repeated-measures correlation was calculated for the 3000-m speed at T1 to T4 and the corresponding speeds at SFT., Results: Significant associations (r = .68-.93; P < .001) were found between the speeds of the SFT and the peak and lactate threshold speeds of the incremental treadmill test. Intraclass correlations varied between .77 and .96, being the highest for the average speed of 6 × 3-minute intervals. Repeated-measures correlation was significant (P < .05) for the 9/20 (r = .24), 13/20 (r = .24), and 6 × 3-minute intervals (r = .29)., Conclusions: The SFT seemed a reproducible method to estimate endurance performance in recreational runners. The sensitivity to track short-term and small-magnitude changes in performance seems more limited and might require more standardized conditions.

Purpose: To study whether, during typical-level running, non-rear-foot strikers (non-RFS) or rear-foot strikers (RFS) presented a similar or different extent of neuromuscular fatigue after a prolonged graded run., Methods: Sixteen experienced male trail runners (8 non-RFS and 8 RFS) performed a 2.5-hour treadmill graded running exercise. Before and after exercise, neuromuscular tests were performed to assess neuromuscular fatigue of the plantar flexors. Biomechanical gait parameters were acquired with an instrumented treadmill, and electromyographic activity of the lower-limb muscles was collected as an index of muscle activation., Results: There were no significant time × foot strike interactions for neuromuscular (all P ≥ .742), muscle activation (all P ≥ .157), or biomechanical (all P ≥ .096) variables., Conclusions: A dominant level running foot-strike pattern did not directly affect the extent of neuromuscular fatigue during a prolonged graded run. This suggests that no ideal running foot-strike pattern exists to minimize neuromuscular fatigue during prolonged-duration races wherein cumulative uphill and downhill segments are high, such as in trail running.

Understanding the changes in running mechanics caused by fatigue is essential to assess its impact on athletic performance. Changes in running biomechanics after constant speed conditions are well documented, but the adaptive responses after a maximal incremental test are unknown. We compared the spatiotemporal, joint kinematics, elastic mechanism, and external work parameters before and after a maximal incremental treadmill test. Eighteen recreational runners performed 2-minute runs at 8 km·h-1 before and after a maximal incremental test on a treadmill. Kinematics, elastic parameters, and external work were determined using the OpenCap and OpenSim software. We did not find differences in spatiotemporal parameters and elastic parameters (mechanical work, ankle, and knee motion range) between premaximal and postmaximal test conditions. After the maximal test, the runners flexed their hips more at contact time (19.4°-20.6°, P = .013) and presented a larger range of pelvis rotation at the frontal plane (10.3°-11.4°, P = .002). The fatigue applied in the test directly affects pelvic movements; however, it does not change the lower limb motion or the spatiotemporal and mechanical work parameters in recreational runners. A larger frontal plane motion of the pelvis deserves attention due to biomechanical risk factors associated with injuries.

Purpose: This study examined the acute influence of a bench press (BP) loading on the explosive squat (SQ) performance and vice versa. Methods: Nineteen strength-trained men completed 2 experimental sessions consisting of either a SQ+BP loading or a BP+SQ loading with 3 × 5 + 3 × 3 repetitions at 80% of the 1-repetition maximum in a randomized order. SQ and BP mean propulsive velocity (MPV) were assessed during both loadings, at baseline (T0) as well as immediately after the first (T1) and second strength loading (T2). Results: Both BP and SQ MPV decreased between T0 and T1 in SQ+BP (-6.13 ± 6.13%, p = .014, g = 0.485 and -9.11 ± 7.23%, p  < .001, g = 0.905, respectively) and BP+SQ (-15.15 ± 7.69%, p  < .001, g = 1.316 and -7.18 ± 6.16%, p  < .001, g = 0.724, respectively). Mean BP MPV was lower in set 2 to set 6 in SQ+BP when compared to BP+SQ (-7.90% - 9.88%, all p  < .05, g = 0.523-0.808). Mean SQ MPV was lower in set 1 and set 4 in BP+SQ when compared to SQ+BP (-4.94% - 5.22%, all p  < .001, g = 0.329-0.362). Conclusions: These results demonstrate that the presence of non-local muscle fatigue affects the movement velocity. Therefore, if a training program aims to perform strength training exercises with maximal movement velocity, it is essential to carefully evaluate whether upper and lower body exercises should be carried out within close proximity.

The measurement of skeletal muscle fatigue in response to cycling exercise is commonly done in isometric conditions, potentially limiting its ecological validity, and creating challenges in monitoring the time course of muscle fatigue across an exercise bout. This study aimed to determine if muscle fatigue could be reliably assessed by measuring quadriceps twitch force evoked while pedaling, using instrumented pedals. Nine participants completed three laboratory visits: a step incremental test to determine power output at lactate threshold, and on separate occasions, two constant-intensity bouts at a power output 10% above lactate threshold. Femoral nerve electrical stimulation was applied to elicit quadriceps twitch force both while pedaling (dynamic) and at rest (isometric). The test-retest reliability of the dynamic twitch forces and the agreement between the dynamic and isometric twitch forces were evaluated. Dynamic twitch force was found to have excellent reliability in an unfatigued state (intraclass correlation coefficient (ICC) = 0.920 and mean coefficient of variation (CV) = 7.5%), and maintained good reliability at task failure (ICC = 0.846 and mean CV = 11.5%). When comparing dynamic to isometric twitch forces across the task, there was a greater relative decline in the dynamic condition (P = 0.001). However, when data were normalized to the 5 min timepoint when potentiation between conditions was presumed to be more similar, this difference disappeared (P = 0.207). The reliability of this method was shown to be commensurate with the gold standard method utilizing seated isometric dynamometers and offers a new avenue to monitor the kinetics of muscle fatigue during cycling in real time., (© 2024 The Author(s). European Journal of Sport Science published by Wiley‐VCH GmbH on behalf of European College of Sport Science.)

The aim of this study was to compare the acute effects of compression contrast therapy (CT) and dry needling therapy (DN) on muscle tension (MT), muscle strength (Fmax), pressure pain threshold (PPT), and perfusion (PU) following fatigue of forearm muscles (e.g., flexor carpi radialis) in combat sports athletes. A single-blind randomized controlled trial was employed. Participants first underwent muscle fatigue induction, which involved sustaining an isometric handgrip at 60% of their maximum voluntary contraction in 5-second cycles. This was followed by exposure to one of the regenerative therapies. Forty-five participants were randomly assigned to one of three groups: CT/DN (n = 15), CT/ShDN (n = 15), and ShCT/DN (n = 15). The sham condition (Sh) involved a simulated version of the technique. Measurements were taken at four time points: (i) at rest; (ii) immediately after exercise that led to a state of fatigue; (iii) 5 minutes after therapy (PostTh5min); and (iv) 24 hours after therapy (PostTh24h). Each participant was exposed to one experimental condition and one control condition, thereby undergoing evaluation in two sessions. Significant differences between groups were found in MT during the PostTh5min ( p = 0.005), as well as in PU during the PostTh5min ( p < 0.001) and PU during the PostTh24h ( p < 0.001). All groups showed significant improvements at 5 minutes post-therapy compared to immediately post-muscle fatigue. As conclusions, CT/DN seems to be significantly better for enhancing MT and PU after 5 minutes of muscle fatigue induction. Using either CT, DN, or both combined is recommended to enhance the recovery of muscle functionality and properties, favoring recovery and potentially speeding up performance enhancement., (© Journal of Sports Science and Medicine.)