4,121 results on '"O’Brien, Paul"'
Search Results
102. The workload distribution of acute stroke CT imaging in a level three hospital in Ireland
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Mc Garvey, Caoimhe, Ruddy, Sarah, and O’Brien, Paul
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- 2021
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103. Transient Computational Fluid Dynamics Analysis of Passive Cooling in a Building with Diurnal Radiative Cooling Material Coated onto Its Rooftop
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Kafaei, Amir, primary, Pirvaram, Atousa, additional, Karbasishargh, Kamyab, additional, Massah, Fatemeh, additional, Ning Leung, Siu, additional, Lakzian, Esmail, additional, and O’Brien, Paul G., additional
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- 2023
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104. Cherenkov Telescope Array is Well Suited to Follow Up Gravitational Wave Transients
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Bartos, Imre, Veres, Peter, Nieto, Daniel, Connaughton, Valerie, Humensky, Brian, Hurley, Kevin, Marka, Szabolcs, Meszaros, Peter, Mukherjee, Reshmi, O'Brien, Paul, and Osborne, Julian P.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The first gravitational-wave (GW) observations will greatly benefit from the detection of coincident electromagnetic counterparts. Electromagnetic follow-ups will nevertheless be challenging for GWs with poorly reconstructed directions. GW source localization can be inefficient (i) if only two GW observatories are in operation; (ii) if the detectors' sensitivities are highly non-uniform; (iii) for events near the detectors' horizon distance. For these events, follow-up observations will need to cover 100-1000 square degrees of the sky over a limited period of time, reducing the list of suitable telescopes. We demonstrate that the Cherenkov Telescope Array will be capable of following up GW event candidates over the required large sky area with sufficient sensitivity to detect short gamma-ray bursts, which are thought to originate from compact binary mergers, out to the horizon distance of advanced LIGO/Virgo. CTA can therefore be invaluable starting with the first multimessenger detections, even with poorly reconstructed GW source directions. This scenario also provides a further scientific incentive for GW observatories to further decrease the delay of their event reconstruction.
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- 2014
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105. Scalable synthesis of Cu–Sb–S phases from reactive melts of metal xanthates and effect of cationic manipulation on structural and optical properties
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Alqahtani, Tahani, Khan, Malik Dilshad, Lewis, David J., Zhong, Xiang Li, and O’Brien, Paul
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- 2021
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106. Diverse coral reef invertebrates exhibit patterns of phylosymbiosis
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O’Brien, Paul A., Tan, Shangjin, Yang, Chentao, Frade, Pedro R., Andreakis, Nikos, Smith, Hillary A., Miller, David J., Webster, Nicole S., Zhang, Guojie, and Bourne, David G.
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- 2020
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107. Pre-operative Restraint and Post-operative Hunger, Disinhibition and Emotional Eating Predict Weight Loss at 2 Years Post-laparoscopic Adjustable Gastric Banding
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Hindle, Annemarie, De la Piedad Garcia, Xochitl, Hayden, Melissa, O’Brien, Paul E., and Brennan, Leah
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- 2020
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108. The Currency of Conservation: How Is Landscape Extent Applied in Conservation Planning?
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Solmundson, Kirsten, Bowman, Jeff, Adey, Elizabeth, Baici, Jennifer E., Dillon, Rachel M., Dupuis, Arthur E., Marrotte, Robby R., Morin, Samantha J., Newar, Sasha L., O’Brien, Paul P., and Scott, Laura M.
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- 2020
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109. Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives
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Via, Laura E, Savic, Rada, Weiner, Danielle M, Zimmerman, Matthew D, Prideaux, Brendan, Irwin, Scott M, Lyon, Eddie, O’Brien, Paul, Gopal, Pooja, Eum, Seokyong, Lee, Myungsun, Lanoix, Jean-Philippe, Dutta, Noton K, Shim, TaeSun, Cho, Jeong Su, Kim, Wooshik, Karakousis, Petros C, Lenaerts, Anne, Nuermberger, Eric, Barry, Clifton E, and Dartois, Véronique
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Medical Microbiology ,Biomedical and Clinical Sciences ,HIV/AIDS ,Infectious Diseases ,Rare Diseases ,Prevention ,Vaccine Related ,Tuberculosis ,Orphan Drug ,Biodefense ,Lung ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Infection ,Good Health and Well Being ,pyrazinamide ,pyrazinoic acid ,bioactivation ,Mycobacterium tuberculosis ,host metabolism ,Medical microbiology - Abstract
Pyrazinamide has played a critical role in shortening therapy against drug-sensitive, drug-resistant, active, and latent tuberculosis (TB). Despite widespread recognition of its therapeutic importance, the sterilizing properties of this 60-year-old drug remain an enigma given its rather poor activity in vitro. Here we revisit longstanding paradigms and offer pharmacokinetic explanations for the apparent disconnect between in vitro activity and clinical impact. We show substantial host-mediated conversion of prodrug pyrazinamide (PZA) to the active form, pyrazinoic acid (POA), in TB patients and in animal models. We demonstrate favorable penetration of this pool of circulating POA from plasma into lung tissue and granulomas, where the pathogen resides. In standardized growth inhibition experiments, we show that POA exhibits superior in vitro potency compared to PZA, indicating that the vascular supply of host-derived POA may contribute to the in vivo efficacy of PZA, thereby reducing the apparent discrepancy between in vitro and in vivo activity. However, the results also raise the possibility that subinhibitory concentrations of POA generated by the host could fuel the emergence of resistance to both PZA and POA. In contrast to widespread expectations, we demonstrate good oral bioavailability and exposure in preclinical species in pharmacokinetic studies of oral POA. Baseline exposure of oral POA can be further increased by the xanthine oxidase inhibitor and approved gout drug allopurinol. These promising results pave the way for clinical investigations of oral POA as a therapeutic alternative or an add-on to overcome PZA resistance and salvage this essential TB drug.
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- 2015
110. The Hot and Energetic Universe: Luminous extragalactic transients
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Jonker, Peter, O'Brien, Paul, Amati, Lorenzo, Atteia, Jean-Luc, Campana, Sergio, Evans, Phil, Fender, Rob, Kouveliotou, Chryssa, Lodato, Giuseppe, Osborne, Julian, Piro, Luigi, Rau, Arne, Tanvir, Nial, and Willingale, Richard
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We discuss the importance and potential contribution of Athena+ to the science questions related to gamma-ray bursts, tidal disruption events and supernova shock break-out. Athena+ will allow breakthrough observations involving high-resolution X-ray spectroscopic observations of high-z gamma-ray bursts, observations of tidal disruption events tailored to determine the mass and potentially the spin of the black hole responsible for the tidal disruption and observations of X-rays from the supernova shock breakout providing a measure of the radius of the exploding star or of the companion in the case of type Ia supernovae. We briefly discuss survey facilities that will provide triggers to these events envisaged to be operational around 2028., Comment: Supporting paper for the science theme "The Hot and Energetic Universe" to be implemented by the Athena+ X-ray observatory (http://www.the-athena-x-ray-observatory.eu). 8 pages, 3 figures
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- 2013
111. The Hot and Energetic Universe: A White Paper presenting the science theme motivating the Athena+ mission
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Nandra, Kirpal, Barret, Didier, Barcons, Xavier, Fabian, Andy, Herder, Jan-Willem den, Piro, Luigi, Watson, Mike, Adami, Christophe, Aird, James, Afonso, Jose Manuel, Alexander, Dave, Argiroffi, Costanza, Amati, Lorenzo, Arnaud, Monique, Atteia, Jean-Luc, Audard, Marc, Badenes, Carles, Ballet, Jean, Ballo, Lucia, Bamba, Aya, Bhardwaj, Anil, Battistelli, Elia Stefano, Becker, Werner, De Becker, Michaël, Behar, Ehud, Bianchi, Stefano, Biffi, Veronica, Bîrzan, Laura, Bocchino, Fabrizio, Bogdanov, Slavko, Boirin, Laurence, Boller, Thomas, Borgani, Stefano, Borm, Katharina, Bouché, Nicolas, Bourdin, Hervé, Bower, Richard, Braito, Valentina, Branchini, Enzo, Branduardi-Raymont, Graziella, Bregman, Joel, Brenneman, Laura, Brightman, Murray, Brüggen, Marcus, Buchner, Johannes, Bulbul, Esra, Brusa, Marcella, Bursa, Michal, Caccianiga, Alessandro, Cackett, Ed, Campana, Sergio, Cappelluti, Nico, Cappi, Massimo, Carrera, Francisco, Ceballos, Maite, Christensen, Finn, Chu, You-Hua, Churazov, Eugene, Clerc, Nicolas, Corbel, Stephane, Corral, Amalia, Comastri, Andrea, Costantini, Elisa, Croston, Judith, Dadina, Mauro, D'Ai, Antonino, Decourchelle, Anne, Della Ceca, Roberto, Dennerl, Konrad, Dolag, Klaus, Done, Chris, Dovciak, Michal, Drake, Jeremy, Eckert, Dominique, Edge, Alastair, Ettori, Stefano, Ezoe, Yuichiro, Feigelson, Eric, Fender, Rob, Feruglio, Chiara, Finoguenov, Alexis, Fiore, Fabrizio, Galeazzi, Massimiliano, Gallagher, Sarah, Gandhi, Poshak, Gaspari, Massimo, Gastaldello, Fabio, Georgakakis, Antonis, Georgantopoulos, Ioannis, Gilfanov, Marat, Gitti, Myriam, Gladstone, Randy, Goosmann, Rene, Gosset, Eric, Grosso, Nicolas, Guedel, Manuel, Guerrero, Martin, Haberl, Frank, Hardcastle, Martin, Heinz, Sebastian, Herrero, Almudena Alonso, Hervé, Anthony, Holmstrom, Mats, Iwasawa, Kazushi, Jonker, Peter, Kaastra, Jelle, Kara, Erin, Karas, Vladimir, Kastner, Joel, King, Andrew, Kosenko, Daria, Koutroumpa, Dimita, Kraft, Ralph, Kreykenbohm, Ingo, Lallement, Rosine, Lanzuisi, Giorgio, Lee, J., Lemoine-Goumard, Marianne, Lobban, Andrew, Lodato, Giuseppe, Lovisari, Lorenzo, Lotti, Simone, McCharthy, Ian, McNamara, Brian, Maggio, Antonio, Maiolino, Roberto, De Marco, Barbara, de Martino, Domitilla, Mateos, Silvia, Matt, Giorgio, Maughan, Ben, Mazzotta, Pasquale, Mendez, Mariano, Merloni, Andrea, Micela, Giuseppina, Miceli, Marco, Mignani, Robert, Miller, Jon, Miniutti, Giovanni, Molendi, Silvano, Montez, Rodolfo, Moretti, Alberto, Motch, Christian, Nazé, Yaël, Nevalainen, Jukka, Nicastro, Fabrizio, Nulsen, Paul, Ohashi, Takaya, O'Brien, Paul, Osborne, Julian, Oskinova, Lida, Pacaud, Florian, Paerels, Frederik, Page, Mat, Papadakis, Iossif, Pareschi, Giovanni, Petre, Robert, Petrucci, Pierre-Olivier, Piconcelli, Enrico, Pillitteri, Ignazio, Pinto, C., de Plaa, Jelle, Pointecouteau, Etienne, Ponman, Trevor, Ponti, Gabriele, Porquet, Delphine, Pounds, Ken, Pratt, Gabriel, Predehl, Peter, Proga, Daniel, Psaltis, Dimitrios, Rafferty, David, Ramos-Ceja, Miriam, Ranalli, Piero, Rasia, Elena, Rau, Arne, Rauw, Gregor, Rea, Nanda, Read, Andy, Reeves, James, Reiprich, Thomas, Renaud, Matthieu, Reynolds, Chris, Risaliti, Guido, Rodriguez, Jerome, Hidalgo, Paola Rodriguez, Roncarelli, Mauro, Rosario, David, Rossetti, Mariachiara, Rozanska, Agata, Rovilos, Emmanouil, Salvaterra, Ruben, Salvato, Mara, Di Salvo, Tiziana, Sanders, Jeremy, Sanz-Forcada, Jorge, Schawinski, Kevin, Schaye, Joop, Schwope, Axel, Sciortino, Salvatore, Severgnini, Paola, Shankar, Francesco, Sijacki, Debora, Sim, Stuart, Schmid, Christian, Smith, Randall, Steiner, Andrew, Stelzer, Beate, Stewart, Gordon, Strohmayer, Tod, Strüder, Lothar, Sun, Ming, Takei, Yoh, Tatischeff, V., Tiengo, Andreas, Tombesi, Francesco, Trinchieri, Ginevra, Tsuru, T. G., Ud-Doula, Asif, Ursino, Eugenio, Valencic, Lynne, Vanzella, Eros, Vaughan, Simon, Vignali, Cristian, Vink, Jacco, Vito, Fabio, Volonteri, Marta, Wang, Daniel, Webb, Natalie, Willingale, Richard, Wilms, Joern, Wise, Michael, Worrall, Diana, Young, Andrew, Zampieri, Luca, Zand, Jean In't, Zane, Silvia, Zezas, Andreas, Zhang, Yuying, and Zhuravleva, Irina
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Cosmology and Extragalactic Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
This White Paper, submitted to the recent ESA call for science themes to define its future large missions, advocates the need for a transformational leap in our understanding of two key questions in astrophysics: 1) How does ordinary matter assemble into the large scale structures that we see today? 2) How do black holes grow and shape the Universe? Hot gas in clusters, groups and the intergalactic medium dominates the baryonic content of the local Universe. To understand the astrophysical processes responsible for the formation and assembly of these large structures, it is necessary to measure their physical properties and evolution. This requires spatially resolved X-ray spectroscopy with a factor 10 increase in both telescope throughput and spatial resolving power compared to currently planned facilities. Feedback from supermassive black holes is an essential ingredient in this process and in most galaxy evolution models, but it is not well understood. X-ray observations can uniquely reveal the mechanisms launching winds close to black holes and determine the coupling of the energy and matter flows on larger scales. Due to the effects of feedback, a complete understanding of galaxy evolution requires knowledge of the obscured growth of supermassive black holes through cosmic time, out to the redshifts where the first galaxies form. X-ray emission is the most reliable way to reveal accreting black holes, but deep survey speed must improve by a factor ~100 over current facilities to perform a full census into the early Universe. The Advanced Telescope for High Energy Astrophysics (Athena+) mission provides the necessary performance (e.g. angular resolution, spectral resolution, survey grasp) to address these questions and revolutionize our understanding of the Hot and Energetic Universe. These capabilities will also provide a powerful observatory to be used in all areas of astrophysics., Comment: Submitted in response to the call for White Papers for the definition of the L2 and L3 missions in the ESA Science program. More information: http://www.the-athena-x-ray-observatory.eu/. 19 pages, 12 figures, 4 tables
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- 2013
112. The Transient Gravitational-Wave Sky
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Andersson, Nils, Baker, John, Belczynski, Kris, Bernuzzi, Sebastiano, Berti, Emanuele, Cadonati, Laura, Cerda-Duran, Pablo, Clark, James, Favata, Marc, Finn, Lee Samuel, Fryer, Chris, Giacomazzo, Bruno, Gonzalez, Jose Antonio, Hendry, Martin, Heng, Ik Siong, Hild, Stefan, Johnson-McDaniel, Nathan, Kalmus, Peter, Klimenko, Sergei, Kobayashi, Shiho, Kokkotas, Kostas, Laguna, Pablo, Lehner, Luis, Levin, Janna, Liebling, Steve, MacFadyen, Andrew, Mandel, Ilya, Marka, Szabolcs, Marka, Zsuzsa, Neilsen, David, O'Brien, Paul, Perna, Rosalba, Pfeiffer, Harald, Read, Jocelyn, Reisswig, Christian, Rodriguez, Carl, Ruffert, Max, Schnetter, Erik, Searle, Antony, Shawhan, Peter, Shoemaker, Deirdre, Soderberg, Alicia, Sperhake, Ulrich, Sutton, Patrick, Tanvir, Nial, Was, Michal, and Whitcomb, Stan
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General Relativity and Quantum Cosmology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Interferometric detectors will very soon give us an unprecedented view of the gravitational-wave sky, and in particular of the explosive and transient Universe. Now is the time to challenge our theoretical understanding of short-duration gravitational-wave signatures from cataclysmic events, their connection to more traditional electromagnetic and particle astrophysics, and the data analysis techniques that will make the observations a reality. This paper summarizes the state of the art, future science opportunities, and current challenges in understanding gravitational-wave transients., Comment: 33 pages, 2 figures
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- 2013
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113. Can magnetar spin-down power extended emission in some short GRBs?
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Gompertz, Ben, O'Brien, Paul, Wynn, Graham, and Rowlinson, Antonia
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Extended emission gamma-ray bursts are a subset of the `short' class of burst which exhibit an early time rebrightening of gamma emission in their light curves. This extended emission arises just after the initial emission spike, and can persist for up to hundreds of seconds after trigger. When their light curves are overlaid, our sample of 14 extended emission bursts show a remarkable uniformity in their evolution, strongly suggesting a common central engine powering the emission. One potential central engine capable of this is a highly magnetized, rapidly rotating neutron star, known as a magnetar. Magnetars can be formed by two compact objects coallescing, a scenario which is one of the leading progenitor models for short bursts in general. Assuming a magnetar is formed, we gain a value for the magnetic field and late time spin period for 9 of the extended emission bursts by fitting the magnetic dipole spin-down model of Zhang & Meszaros (2001). Assuming the magnetic field is constant, and the observed energy release during extended emission is entirely due to the spin-down of this magnetar, we then derive the spin period at birth for the sample. We find all birth spin periods are in good agreement with those predicted for a newly born magnetar., Comment: 7 pages, 4 figures, 3 tables. Accepted for publication in MNRAS
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- 2013
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114. Gamma-Ray Burst Science in the Era of the Cherenkov Telescope Array
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Inoue, Susumu, Granot, Jonathan, O'Brien, Paul T., Asano, Katsuaki, Bouvier, Aurelien, Carosi, Alessandro, Connaughton, Valerie, Garczarczyk, Markus, Gilmore, Rudy, Hinton, Jim, Inoue, Yoshiyuki, Ioka, Kunihito, Kakuwa, Jun, Markoff, Sera, Murase, Kohta, Osborne, Julian P., Otte, A. Nepomuk, Starling, Rhaana, Tajima, Hiroyasu, Teshima, Masahiro, Toma, Kenji, Wagner, Stefan, Wijers, Ralph A. M. J., Williams, David A., Yamamoto, Tokonatsu, and Yamazaki, Ryo
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We outline the science prospects for gamma-ray bursts (GRBs) with the Cherenkov Telescope Array (CTA), the next-generation ground-based gamma-ray observatory operating at energies above few tens of GeV. With its low energy threshold, large effective area and rapid slewing capabilities, CTA will be able to measure the spectra and variability of GRBs at multi-GeV energies with unprecedented photon statistics, and thereby break new ground in elucidating the physics of GRBs, which is still poorly understood. Such measurements will also provide crucial diagnostics of ultra-high-energy cosmic ray and neutrino production in GRBs, advance observational cosmology by probing the high-redshift extragalactic background light and intergalactic magnetic fields, and contribute to fundamental physics by testing Lorentz invariance violation with high precision. Aiming to quantify these goals, we present some simulated observations of GRB spectra and light curves, together with estimates of their detection rates with CTA. Although the expected detection rate is modest, of order a few GRBs per year, hundreds or more high-energy photons per burst may be attainable once they are detected. We also address various issues related to following up alerts from satellites and other facilities with CTA, as well as follow-up observations at other wavelengths. The possibility of discovering and observing GRBs from their onset including short GRBs during a wide-field survey mode is also briefly discussed., Comment: Astroparticle Physics, in press, for the special issue on "Physics with the Cherenkov Telescope Array"; 28 pages, 19 figures; replaced with cosmetically revised version
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- 2013
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115. Synthesis of iron sulfide thin films and powders from new xanthate precursors
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Almanqur, Laila, Alam, Firoz, Whitehead, George, Vitorica-yrezabal, Inigo, O'Brien, Paul, and Lewis, David J.
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- 2019
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116. Clinical Transformation Through Change Management Case Study: Chest Pain in the Emergency Department
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Kuhlman, Jeffrey, Moorhead, David, Kerpchar, Joyce, Peach, Daniel J., Ahmad, Sarfraz, and O'Brien, Paul B.
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- 2019
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117. The Gravitational-wave Optical Transient Observer (GOTO)
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Marshall, Heather K., Spyromilio, Jason, Usuda, Tomonori, Dyer, Martin J., Ackley, Kendall, Jiménez-Ibarra, Felipe, Lyman, Joseph, Ulaczyk, Krzysztof, Steeghs, Danny, Galloway, Duncan K., Dhillon, Vik S., O'Brien, Paul, Ramsay, Gavin, Noysena, Kanthanakorn, Kotak, Rubina, Breton, Rene, Nuttall, Laura, Pallé, Enric, Pollacco, Don, Killestein, Tom, Kumar, Amit, O'Neill, David, Kelsey, Lisa, Godson, Ben, and Jarvis, Dan
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- 2024
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118. THESEUS: Transient High Energy Sky and Early Universe Surveyor
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den Herder, Jan-Willem A., Nikzad, Shouleh, Nakazawa, Kazuhiro, Bozzo, Enrico, Amati, Lorenzo, O’Brien, Paul, Goetz, Diego, and Santangelo, Andrea
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- 2024
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119. Remarkable Spectral Variability of PDS 456
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Behar, Ehud, Kaspi, Shai, Reeves, James, Turner, T. J., Mushotzky, Richard, and O'Brien, Paul T.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report on the highest to date signal-to-noise-ratio X-ray spectrum of the luminous quasar PDS 456, as obtained during two XMM-Newton orbits in September 2007. The present spectrum is considerably different from several previous X-ray spectra recorded for PDS 456 since 1998. The ultra-high-velocity outflow seen as recently as February 2007 is not detected in absorption. Conversely, a significant reflection component is detected. The reflection model suggests the reflecting medium may be outflowing at a velocity v/c = -0.06 +/- 0.02. The present spectrum is analyzed in the context of the previous ones in an attempt to understand all spectra within the framework of a single model. We examine whether an outflow with variable partial covering of the X-ray source along the line of sight that also reflects the source from other lines of sight can explain the dramatic variations in the broad-band spectral curvature of PDS 456. It is established that absorption plays a major role in shaping the spectrum of other epochs, while the 2007 XMM-Newton spectrum is dominated by reflection, and the coverage of the source by the putative outflow is small (< 20%)., Comment: submitted to ApJ
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- 2009
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120. Going out with a bang: compact object collisions resulting from supernovae in binary systems
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Troja, Eleonora, Wynn, Graham A., O'Brien, Paul T., and Rosswog, Stephan
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Binary star systems containing a neutron star or a black hole with an evolved, massive star are dynamically perturbed when the latter undergoes a supernova explosion. It is possible that the natal kick received by the newly-formed neutron star in the supernova may place the stellar remnants into a bound, highly eccentric orbit. In this case, the two compact objects can tidally interact and spiral into one another on a short timescale. The interaction with an accretion disc of supernova debris is also considered. We quantify the likelihood of such events and show that they would be expected to produce a high-energy transient, possibly a short gamma-ray burst, typically within a few days of the supernova., Comment: 7 pages, 4 figures, accepted for publication in MNRAS
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- 2009
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121. Are all short-hard gamma-ray bursts produced from mergers of compact stellar objects?
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Virgili, Francisco J., Zhang, Bing, O'Brien, Paul, and Troja, Eleonora
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The origin and progenitors of short-hard gamma-ray bursts remain a puzzle and a highly debated topic. Recent Swift observations suggest that these GRBs may be related to catastrophic explosions in degenerate compact stars, denoted as "Type I" GRBs. The most popular models include the merger of two compact stellar objects (NS-NS or NS-BH). We utilize a Monte Carlo approach to determine whether a merger progenitor model can self-consistently account for all the observations of short-hard GRBs, including a sample with redshift measurements in the Swift era (z-known sample) and the CGRO/BATSE sample. We apply various merger time delay distributions invoked in compact star merger models to derive the redshift distributions of these Type I GRBs, and then constrain the unknown luminosity function of Type I GRBs using the observed luminosity-redshift (L - z) distributions of the z-known sample. The best luminosity function model, together with the adopted merger delay model, are then applied to confront the peak flux distribution (log N - log P distribution) of the BATSE and Swift samples. We find that for all the merger models invoking a range of merger delay time scales (including those invoking a large fraction of "prompt mergers"), it is difficult to reconcile the models with all the data. The data are instead statistically consistent with the following two possible scenarios. First, that short/hard GRBs are a superposition of compact-star-merger origin (Type I) GRBs and a population of GRBs that track the star formation history, which are probably related to the deaths of massive stars (Type II GRBs). Sec- ond, the entire short/hard GRB population is consistent with a typical delay of 2 Gyr with respect to the star formation history with modest scatter. This may point towards a different Type I progenitor than the traditional compact star merger models., Comment: ApJ, accepted. Addition models and statistical tests added, main conclusion expanded but largely unchanged
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- 2009
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122. Phase 2 Trial of Induction Gemcitabine, Oxaliplatin, and Cetuximab Followed by Selective Capecitabine-Based Chemoradiation in Patients With Borderline Resectable or Unresectable Locally Advanced Pancreatic Cancer
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Esnaola, Nestor F, Chaudhary, Uzair B, O'Brien, Paul, Garrett-Mayer, Elizabeth, Camp, E Ramsay, Thomas, Melanie B, Cole, David J, Montero, Alberto J, Hoffman, Brenda J, Romagnuolo, Joseph, Orwat, Kelly P, and Marshall, David T
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Rare Diseases ,Cancer ,Pancreatic Cancer ,Patient Safety ,Clinical Trials and Supportive Activities ,Digestive Diseases ,Clinical Research ,Evaluation of treatments and therapeutic interventions ,6.5 Radiotherapy and other non-invasive therapies ,6.1 Pharmaceuticals ,Adenocarcinoma ,Adult ,Aged ,Antineoplastic Combined Chemotherapy Protocols ,Capecitabine ,Chemoradiotherapy ,Deoxycytidine ,Drug Administration Schedule ,Female ,Fluorouracil ,Humans ,Induction Chemotherapy ,Male ,Middle Aged ,Organoplatinum Compounds ,Oxaliplatin ,Pancreatic Neoplasms ,Radiotherapy Dosage ,Radiotherapy ,Intensity-Modulated ,Gemcitabine ,Other Physical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
PurposeTo evaluate, in a phase 2 study, the safety and efficacy of induction gemcitabine, oxaliplatin, and cetuximab followed by selective capecitabine-based chemoradiation in patients with borderline resectable or unresectable locally advanced pancreatic cancer (BRPC or LAPC, respectively).Methods and materialsPatients received gemcitabine and oxaliplatin chemotherapy repeated every 14 days for 6 cycles, combined with weekly cetuximab. Patients were then restaged; "downstaged" patients with resectable disease underwent attempted resection. Remaining patients were treated with chemoradiation consisting of intensity modulated radiation therapy (54 Gy) and concurrent capecitabine; patients with borderline resectable disease or better at restaging underwent attempted resection.ResultsA total of 39 patients were enrolled, of whom 37 were evaluable. Protocol treatment was generally well tolerated. Median follow-up for all patients was 11.9 months. Overall, 29.7% of patients underwent R0 surgical resection (69.2% of patients with BRPC; 8.3% of patients with LAPC). Overall 6-month progression-free survival (PFS) was 62%, and median PFS was 10.4 months. Median overall survival (OS) was 11.8 months. In patients with LAPC, median OS was 9.3 months; in patients with BRPC, median OS was 24.1 months. In the group of patients who underwent R0 resection (all of which were R0 resections), median survival had not yet been reached at the time of analysis.ConclusionsThis regimen was well tolerated in patients with BRPC or LAPC, and almost one-third of patients underwent R0 resection. Although OS for the entire cohort was comparable to that in historical controls, PFS and OS in patients with BRPC and/or who underwent R0 resection was markedly improved.
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- 2014
123. An experimental comparison of thermal energy storage in directly and indirectly radiated adsorbent beds integrated with solar thermal collectors.
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Narwal, Kapil, Massah, Fatemeh, Kempers, Roger, and O'Brien, Paul G.
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SOLAR thermal energy ,SOLAR collectors ,SOLAR energy ,HEAT storage ,SOLAR heating ,ENERGY storage ,ENERGY density ,HEAT losses - Abstract
Adsorbents heated using solar energy can be used to achieve thermal energy storage and sorption refrigeration with low environmental impacts. This research compares two different methods of heating adsorbents with solar energy to store thermal energy: (1) by exposing the adsorbents to incident light transmitted through a solar collector window, and (2) by heating a highly absorbing solar collector cover, and then transferring the heat from this solar absorber to adsorbents located beneath it. To carry out this comparison experiments are conducted for three cases of adsorbent beds using zeolite 13X and water as the adsorbent-adsorbate pair. In the first case, the top of the adsorbent bed is a polycarbonate sheet, and the zeolites are heated directly by solar-simulated light transmitted through this sheet. In the second case, a blackened aluminum sheet is placed beneath the polycarbonate sheet to generate heat by absorbing incident light. For the third case, the blackened aluminum absorber is placed directly on top of the zeolite beads and the absorber is isolated from the walls of the reactor to avoid heat losses. The outcomes reveal an energy storage density (ESD) of 43.6 kWh/m³ (63.4 Wh/kg) when light is directly incident onto the zeolite 13X and an ESD of 33.3 kWh/m³ (48.4 Wh/kg) when light is incident onto a blackened absorber plate that transfers heat to Zeolite beads residing beneath it. However, ESD values were improved to 48.9 kWh/m³ (71.0 Wh/kg) when the blackened absorber plate was thermally insulated from the walls of the adsorbent bed. These results demonstrate the importance of an optimal absorber arrangement in enhancing the adsorption process for the purpose of elevating energy storage densities. [ABSTRACT FROM AUTHOR]
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- 2024
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124. Heavy element production in a compact object merger observed by JWST
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Levan, Andrew, primary, Gompertz, Benjamin P., additional, Salafia, Om Sharan, additional, Bulla, Mattia, additional, Burns, Eric, additional, Hotokezaka, Kenta, additional, Izzo, Luca, additional, Lamb, Gavin P., additional, Malesani, Daniele B., additional, Oates, Samantha R., additional, Ravasio, Maria Edvige, additional, Rouco Escorial, Alicia, additional, Schneider, Benjamin, additional, Sarin, Nikhil, additional, Schulze, Steve, additional, Tanvir, Nial R., additional, Ackley, Kendall, additional, Anderson, Gemma, additional, Brammer, Gabriel B., additional, Christensen, Lise, additional, Dhillon, Vikram S., additional, Evans, Phil A., additional, Fausnaugh, Michael, additional, Fong, Wen-fai, additional, Fruchter, Andrew S., additional, Fryer, Chris, additional, Fynbo, Johan P. U., additional, Gaspari, Nicola, additional, Heintz, Kasper E., additional, Hjorth, Jens, additional, Kennea, Jamie A., additional, Kennedy, Mark R., additional, Laskar, Tanmoy, additional, Leloudas, Giorgos, additional, Mandel, Ilya, additional, Martin-Carrillo, Antonio, additional, Metzger, Brian D., additional, Nicholl, Matt, additional, Nugent, Anya, additional, Palmerio, Jesse T., additional, Pugliese, Giovanna, additional, Rastinejad, Jillian, additional, Rhodes, Lauren, additional, Rossi, Andrea, additional, Saccardi, Andrea, additional, Smartt, Stephen J., additional, Stevance, Heloise F., additional, Tohuvavohu, Aaron, additional, van der Horst, Alexander, additional, Vergani, Susanna D., additional, Watson, Darach, additional, Barclay, Thomas, additional, Bhirombhakdi, Kornpob, additional, Breedt, Elmé, additional, Breeveld, Alice A., additional, Brown, Alexander J., additional, Campana, Sergio, additional, Chrimes, Ashley A., additional, D’Avanzo, Paolo, additional, D’Elia, Valerio, additional, De Pasquale, Massimiliano, additional, Dyer, Martin J., additional, Galloway, Duncan K., additional, Garbutt, James A., additional, Green, Matthew J., additional, Hartmann, Dieter H., additional, Jakobsson, Páll, additional, Kerry, Paul, additional, Kouveliotou, Chryssa, additional, Langeroodi, Danial, additional, Le Floc’h, Emeric, additional, Leung, James K., additional, Littlefair, Stuart P., additional, Munday, James, additional, O’Brien, Paul, additional, Parsons, Steven G., additional, Pelisoli, Ingrid, additional, Sahman, David I., additional, Salvaterra, Ruben, additional, Sbarufatti, Boris, additional, Steeghs, Danny, additional, Tagliaferri, Gianpiero, additional, Thöne, Christina C., additional, de Ugarte Postigo, Antonio, additional, and Kann, David Alexander, additional
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- 2023
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125. Using sentinel nodes to evaluate changing connectivity in a protected area network
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O’Brien, Paul, primary, Carr, Natasha, additional, and Bowman, Jeff, additional
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- 2023
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126. Digital Patient Reported Outcome Measures Platform for Post–COVID-19 Condition and Other Long-Term Conditions: User-Centered Development and Technical Description
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Sivan, Manoj, primary, Rocha Lawrence, Román, additional, and O'Brien, Paul, additional
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- 2023
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127. Late time observations of GRB080319B: jet break, host galaxy and accompanying supernova
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Tanvir, Nial R., Rol, Evert, Levan, Andrew, Fruchter, Andrew, Granot, Jonathan, Svensson, Karl M., O'Brien, Paul T., Wiersema, Klaas, Starling, Rhaana L. C., Jakobsson, Pall, Fynbo, Johan, Hjorth, Jens, Curran, Peter, van der Horst, Alexander J., Kouveliotou, Chryssa, Racusin, Judith L., Burrows, David N., and Genet, Frank
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Astrophysics - Abstract
The Swift discovered GRB080319B was by far the most distant source ever observed at naked eye brightness, reaching a peak apparent magnitude of 5.3 at a redshift of z=0.937. We present our late-time optical (HST, Gemini & VLT) and X-ray (Chandra) observations, which confirm that an achromatic break occurred in the power-law afterglow light curve at ~11 days post-burst. This most likely indicates that the gamma-ray burst (GRB) outflow was collimated, which for a uniform jet would imply a total energy in the jet E_{jet} \gsim 10^{52} erg. Our observations also show a late-time excess of red light, which is well explained if the GRB was accompanied by a supernova (SN), similar to those seen in some other long-duration GRBs. The latest observations are dominated by light from the host and show that the GRB took place in a faint dwarf galaxy (r(AB)\approx27.0, rest-frame M_B\approx-17.2). This galaxy is small even by the standards of other GRB hosts, which is suggestive of a low metallicity environment. Intriguingly, the properties of this extreme event - a small host and bright supernova - are entirely typical of the very low-luminosity bursts such as GRB980425 and GRB060218., Comment: Revised in response to referee's comments, and with some additional data added
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- 2008
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128. X-Ray Afterglows
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O'Brien, Paul and Willingale, Richard
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Astrophysics - Abstract
We summarise the X-ray temporal and spectral variability properties of GRBs as observed using the Swift satellite. Despite much individual complexity, the flux and spectral variability can be reasonably well described by a combination of two components - which we denote as the prompt and the afterglow. The first, prompt component consists of the burst and its initial decay while the second, afterglow component fits the X-ray plateau phase and subsequent decline observed in the majority of GRBs. When strong spectral variability occurs it is associated with the prompt component while the X-ray plateau and later emission shows little if any spectral variability. We briefly compare the observations with some of the proposed models. Any model for the early or late emission must explain the differences in both temporal and spectral behaviour., Comment: 6 pages, 6 figures. To appear in: 2008 Nanjing GRB Conference, AIP, Eds. Y.F. Huang, Z.G. Dai, B. Zhang
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- 2008
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129. The Dust Scattering Model Can Not Explain The Shallow X-ray Decay in GRB Afterglows
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Shen, Rong-Feng, Willingale, Richard, Kumar, Pawan, O'Brien, Paul T., and Evans, Phil A.
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Astrophysics - Abstract
A dust scattering model was recently proposed to explain the shallow X-ray decay (plateau) observed prevalently in Gamma-Ray Burst (GRB) early afterglows. In this model the plateau is the scattered prompt X-ray emission by the dust located close (about 10 to a few hundred pc) to the GRB site. In this paper we carefully investigate the model and find that the scattered emission undergoes strong spectral softening with time, due to the model's essential ingredient that harder X-ray photons have smaller scattering angle thus arrive earlier, while softer photons suffer larger angle scattering and arrive later. The model predicts a significant change, i.e., $\Delta \b \sim 2 - 3$, in the X-ray spectral index from the beginning of the plateau toward the end of the plateau, while the observed data shows close to zero softening during the plateau and the plateau-to-normal transition phase. The scattering model predicts a big difference between the harder X-ray light curve and the softer X-ray light curve, i.e., the plateau in harder X-rays ends much earlier than in softer X-rays. This feature is not seen in the data. The large scattering optical depths of the dust required by the model imply strong extinction in optical, $A_V \gtrsim $ 10, which contradicts current findings of $A_V= 0.1 - 0.7$ from optical and X-ray afterglow observations. We conclude that the dust scattering model can not explain the X-ray plateaus., Comment: 9 pages, 7 figures, MNRAS in press. Updated references. Added two paragraphs discussing the relation between A_v and X-ray scattering optical depth. Conclusion not changed
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- 2008
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130. Working in and Against Hybrid Landscapes: Reflections on the Skills and Capabilities of Chief Officers in UK Local Government
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Barnett, Neil, primary, Giovannini, Arianna, additional, Griggs, Steven, additional, and O’Brien, Paul, additional
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- 2020
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131. Different progenitors of short hard gamma-ray bursts
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Troja, Eleonora, King, Andrew R., O'Brien, Paul T., Lyons, Nicola, and Cusumano, Giancarlo
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Astrophysics - Abstract
We consider the spatial offsets of short hard gamma-ray bursts (SHBs) from their host galaxies. We show that all SHBs with extended duration soft emission components lie very close to their hosts. We suggest that NS-BH binary mergers offer a natural explanation for the properties of this extended duration/low offset group. SHBs with large offsets have no observed extended emission components and are less likely to have an optically detected afterglow, properties consistent with NS-NS binary mergers occurring in low density environments., Comment: 5 pages, 2 figures, accepted for publication in MNRAS
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- 2007
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132. GRB051022: physical parameters and extinction of a prototype dark burst
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Rol, Evert, van der Horst, Alexander, Wiersema, Klaas, Patel, Sandeep K., Levan, Andrew, Nysewander, Melissa, Kouveliotou, Chryssa, Wijers, Ralph A. M. J., Tanvir, Nial, Reichart, Dan, Fruchter, Andrew S., Graham, John, Ovaldsen, Jan-Erik, Jaunsen, Andreas O., Jonker, Peter, van Ham, Wilbert, Hjorth, Jens, Starling, Rhaana L. C., O'Brien, Paul T., Fynbo, Johan, Burrows, David N., and Strom, Richard
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Astrophysics - Abstract
GRB051022 was undetected to deep limits in early optical observations, but precise astrometry from radio and X-ray showed that it most likely originated in a galaxy at z~0.8. We report radio, optical, near infra-red and X-ray observations of GRB051022. Using the available X-ray and radio data, we model the afterglow and calculate the energetics of the afterglow, finding it to be an order of magnitude lower than that of the prompt emission. The broad-band modeling also allows us to precisely define various other physical parameters and the minimum required amount of extinction, to explain the absence of an optical afterglow. Our observations suggest a high extinction, at least 2.3 magnitudes in the infrared (J) and at least 5.4 magnitudes in the optical (U) in the host-galaxy restframe. Such high extinctions are unusual for GRBs, and likely indicate a geometry where our line of sight to the burst passes through a dusty region in the host that is not directly co-located with the burst itself., Comment: 18 pages, 1 figure. Accepted to ApJ, includes referee's comments
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- 2007
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133. An Update on the X-ray transient Narrow-Line Seyfert 1 galaxy WPVS 007: Swift observations of UV variability and persistence of X-ray faintness
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Grupe, Dirk, Schady, Patricia, Leighly, Karen M., Komossa, Stefanie, O'Brien, Paul, and Nousek, John A.
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Astrophysics - Abstract
We report on the detection of UV variability and the persistence of X-ray faintness of the X-ray transient Narrow-Line Seyfert 1 galaxy WPVS 007 based on the first year of monitoring this AGN with Swift between 2005 October and 2007 January. WPVS 007 has been an unusual source. While being X-ray bright during the ROSAT All-Sky Survey it has been extremely faint in all following X-ray observations. Swift also finds this NLS1 to be X-ray faint and not detected in the Swift X-Ray Telescope at an 3$\sigma$ upper limit of $2.6\times 10^{-17}$ W m$^{-2}$ in the 0.3-10.0 keV band and confirms that the AGN is still in a low state. During the 2006 July and December observations with \swift's UV-Optical Telescope (UVOT) the AGN became fainter by about 0.2 mag in the UV filters and by about 0.1 mag in V, B, and U compared with the 2005 October to 2006 January and 2006 September/October observations followed by a rebrightening in the 2007 January observation. This variability can be caused either by a change in the absorption column density and therefore the reddening in the UV, or by flux variations of the central engine. We also noticed that the flux in the UVOT filters agree with earlier measurements by the International Ultraviolet Explorer taken between 1993-1995, but spectra taken by the Hubble Space Telescope Faint Object Spectrograph show that WPVS 007 was fainter in the UV by a factor of at least 2 in 1996. The flat optical/UV spectrum suggests that some UV extinction is present in the spectrum, but that alone cannot at all account for the dramatic fading in the X-ray flux. Most likely we see a partial covering absorber in X-rays. Alternatively, the current X-ray emission seen from WPVS 007 may also be the emission from the host galaxy., Comment: Accepted for publications in the Astronomical Journal, 14 pages, 5 figures, 4 tables
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- 2007
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134. GRB Radiative Efficiencies Derived from the Swift Data: GRBs vs. XRFs, Long vs. Short
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Zhang, Bing, Liang, Enwei, Page, Kim L., Grupe, Dirk, Zhang, Bin-Bin, Barthelmy, Scott D., Burrows, David N., Campana, Sergio, Chincarini, Guido, Gehrels, Neil, Kobayashi, Shiho, Meszaros, Peter, Moretti, Alberto, Nousek, John A., O'Brien, Paul T., Osborne, Julian P., Roming, Peter W. A., Sakamoto, Takanori, Schady, Patricia, and Willingale, Richard
- Subjects
Astrophysics - Abstract
We systematically analyze the prompt emission and the early afterglow data of a sample of 31 GRBs detected by {\em Swift} before September 2005, and estimate the GRB radiative efficiency. BAT's narrow band inhibits a precise determination of the GRB spectral parameters, and we have developed a method to estimate these parameters with the hardness ratio information. The shallow decay component commonly existing in early X-ray afterglows, if interpreted as continuous energy injection in the external shock, suggests that the GRB efficiency previously derived from the late-time X-ray data were not reliable. We calculate two radiative efficiencies using the afterglow kinetic energy E_K derived at the putative deceleration time t_{dec}) and at the break time (t_b) when the energy injection phase ends, respectively. At t_b XRFs appear to be less efficient than normal GRBs. However, when we analyze the data at t_{dec} XRFs are found to be as efficient as GRBs. Short GRBs have similar radiative efficiencies to long GRBs despite of their different progenitors. Twenty-two bursts in the sample are identified to have the afterglow cooling frequency below the X-ray band. Assuming \epsilon_e = 0.1, we find \eta_\gamma(t_b) usually <10% and \eta_\gamma (t_{dec}) varying from a few percents to > 90%. Nine GRBs in the sample have the afterglow cooling frequency above the X-ray band for a very long time. This suggests a very small \epsilon_B and/or a very low ambient density n., Comment: 43 pages, 10 figures, ApJ, in press
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- 2006
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135. Swift Observations of the highly X-ray variable Narrow Line Seyfert 1 galaxy RX J0148.3-2758
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Grupe, Dirk, Leighly, Karen M., Komossa, Stefanie, Schady, Patricia, O'Brien, Paul T., Burrows, Davis N., and Nousek, John A.
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Astrophysics - Abstract
We report on Swift observations of the Narrow-Line Seyfert 1 galaxy (NLS1) RX J0148.3--2758. It was observed for 41.6 ks in 2005 May and for 15.8 ks in 2005 December. On short as well as on long timescales RX J0148.3--2758 is a highly variable source. It doubles its X-ray flux within 18-25 ks. The observation of 2005 December 09, which had a flux 4 times lower than during the 2005 May observations, shows a significant hardening of the X-ray hardness ratio compared with the 2005-May and 2005-December 20/21 observations. A detailed analysis of the X-ray spectra shows that we actually observe two spectral changes in RX J0148.3-2758: First a decrease of the soft X-ray component between 2005 May and December 09, which is most likely due to an increase of the intrinsic absorber column, and second a decrease of the hard X-ray flux in the December 20/21 observations. The soft X-ray spectral slope $\alpha_{\rm X, soft}$=2.58$^{+0.15}_{-0.12}$ during the high state in 2005 May agrees well with that measured by ROSAT (\axs=2.54\plm0.82). In contrast to the strong X-ray variability, the analysis of the Swift UVOT photometry from December 2005 of RX J0148.3--2758 shows no significant variability in any of the 6 UVOT filters. From the simultaneous X-ray and UV observations in 2005 December we measured the X-ray loudness alpha-ox varies between alpha-ox=1.5 and 1.8. Our Swift observations of RX J0148.3-2758 demonstrate the great potential the multi-wavelength observatory Swift has for AGN science. (shortened), Comment: 19 pages; accepted for publication the Astronomical Journal
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- 2006
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136. Swift Observations of GRB 050603: An afterglow with a steep late time decay slope
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Grupe, Dirk, Brown, Peter, Cummings, Jay, Zhang, Bing, Retter, Alon, Burrows, David N., Boyd, Patricia T., Capalbi, Milvia, Gehrels, Neil, Holland, Stephen T., Meszaros, Peter, Nousek, John A., Kennea, Jamie A., O'Brien, Paul, Osborne, Julian, Pagani, Claudio, Racusin, Judith L., Roming, Peter, and Schady, Patricia
- Subjects
Astrophysics - Abstract
We report the results of Swift observations of the Gamma Ray Burst GRB 050603. With a V magnitude V=18.2 about 10 hours after the burst the optical afterglow was the brightest so far detected by Swift and one of the brightest optical afterglows ever seen. The Burst Alert Telescope (BAT) light curves show three fast-rise-exponential-decay spikes with $T_{90}$=12s and a fluence of 7.6$\times 10^{-6}$ ergs cm$^{-2}$ in the 15-150 keV band. With an $E_{\rm \gamma, iso} = 1.26 \times 10^{54}$ ergs it was also one of the most energetic bursts of all times. The Swift spacecraft began observing of the afterglow with the narrow-field instruments about 10 hours after the detection of the burst. The burst was bright enough to be detected by the Swift UV/Optical telescope (UVOT) for almost 3 days and by the X-ray Telescope (XRT) for a week after the burst. The X-ray light curve shows a rapidly fading afterglow with a decay index $\alpha$=1.76$^{+0.15}_{-0.07}$. The X-ray energy spectral index was $\beta_{\rm X}$=0.71\plm0.10 with the column density in agreement with the Galactic value. The spectral analysis does not show an obvious change in the X-ray spectral slope over time. The optical UVOT light curve decays with a slope of $\alpha$=1.8\plm0.2. The steepness and the similarity of the optical and X-ray decay rates suggest that the afterglow was observed after the jet break. We estimate a jet opening angle of about 1-2$^{\circ}$, Comment: 14 pages, accepted for publication in ApJ
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- 2006
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137. Design of an innovative boat ramp to improve the safety of boat launching and retrieval
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Australasian Port and Harbour Conference (16th : 2017 : Cairns, Qld.), McCowan, Andrew, Riedel, Peter, O'Brien, Paul, Schwartz, Robert, and Hinch, Justin
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- 2017
138. Gamma-ray bursts: Restarting the Engine
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King, Andrew, O'Brien, Paul T., Goad, Michael R., Osborne, Julian, Olsson, Emma, and Page, Kim
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Astrophysics - Abstract
Recent gamma-ray burst observations have revealed late-time, highly energetic events which deviate from the simplest expectations of the standard fireball picture. Instead they may indicate that the central engine is active or restarted at late times. We suggest that fragmentation and subsequent accretion during the collapse of a rapidly rotating stellar core offers a natural mechanism for this., Comment: 8 pages, 1 figure; accepted by ApJ Letters
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- 2005
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139. The Connection between Ultraviolet and X-ray Outflows in AGN: the case of PDS 456
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O'Brien, Paul T., Reeves, James N., Simpson, Chris, and Ward, Martin J.
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Astrophysics - Abstract
High-velocity outflows from AGN are a well-known phenomena in terms of the Broad Absorption Lines seen in the UV/optical. More recently, similar, possibly related, outflows have been reported in the X-ray. The most extreme example is seen in the nearby, luminous QSO PDS 456, which displays a massive, high velocity (50000 km s-1), high-ionization X-ray outflow of 10 solar masses yr-1. Here we present the UV spectrum of PDS 456 as observed by the Hubble Space Telescope. We find the UV spectrum is also extreme, displaying very broad emission-lines, with CIV 1549 blueshifted by 5000 km s-1 and a broad Ly-alpha absorption trough blueshifted by 14000-24000 km s-1. No strong, broad high-ionization absorption features are seen. We interpret the combined UV and X-ray spectrum of PDS 456 as the signature of a decelerating, cooling outflow, which may be driven by radiation and/or magnetic field. This outflow may be the source of some of the broad emission and absorption-line gas., Comment: Accepted for publication in MNRAS. 6 pages. 6 figures
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- 2005
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140. Swift XRT and VLT Observations of the Afterglow of GRB 041223
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Burrows, David N., Hill, Joanne E., Chincarini, Guido, Tagliaferri, Gianpiero, Campana, Sergio, Moretti, Alberto, Romano, Patrizia, Malesani, Daniele, Racusin, Judith L., Kobayashi, Shiho, Zhang, Bing, Meszaros, Peter, O'Brien, Paul T., Willingale, Richard, Osborne, Julian P., Cusumano, Giancarlo, Giommi, Paolo, Angelini, Lorella, Abbey, Antony F., Antonelli, L. Angelo, Beardmore, Andrew P., Capalbi, Milvia, Covino, Stefano, D'Avanzo, Paolo, Goad, Michael R., Kennea, Jamie A., Morris, David C., Pagani, Claudio, Page, Kim L., Stella, Luigi, Nousek, John A., Wells, Alan A., and Gehrels, Neil
- Subjects
Astrophysics - Abstract
The Swift Gamma-Ray Burst Explorer, launched on 2004 November 20, is a multiwavelength, autonomous, rapid-slewing observatory for gamma-ray burst (GRB) astronomy. On 2004 December 23, during the activation phase of the mission, the Swift X-Ray Telescope (XRT) was pointed at a burst discovered earlier that day by the Swift Burst Alert Telescope. A fading, uncataloged X-ray source was discovered by the XRT and was observed over a period of about 3 hours, beginning 4.6 hours after the burst. The X-ray detection triggered a VLT observation of the optical/NIR counterpart, located about 1.1 arcseconds from the XRT position. The X-ray counterpart faded rapidly, with a power law index of -1.72 +/- 0.20. The average unabsorbed X-ray flux 4.6-7.9 hours after the burst was 6.5 x 10^{-12} erg cm^{-2} s^{-1} in the 0.5-10 keV band, for a power-law spectrum of photon index 2.02 +/- 0.13 with Galactic absorption. The NIR counterpart was observed at three epochs between 16 and 87 hours after the burst, and faded with a power-law index of -1.14 +/- 0.08 with a reddening-corrected SED power-law slope of -0.40 +/- 0.03. We find that the X-ray and NIR data are consistent with a two-component jet in a wind medium, with an early jet break in the narrow component and an underlying electron index of 1.8-2.0., Comment: 16 pages, including 4 figures. Accepted by Astrophysical Journal (Letters) on 15 February 2005
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- 2005
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141. Exploring processes of adaptation in a group of post-2004 Polish migrants in the UK : an interpretative phenomenological analysis
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O'Brien, Paul
- Subjects
304.8 - Abstract
This study explores how a group of post-2004 Polish migrants have adapted to life in the UK. Eight participants were interviewed and transcripts were analysed using the qualitative methodology of interpretative phenomenological analysis. Four master themes emerged: relating to Poland; relating to the UK; impact on self; and adaptive ability. Migrants’ relationship with Poland and the UK is considered and the psychological impact of migration on the individual is explored. The findings suggest that migration brings benefits as well as challenges. It is evident that participants are equipped with a range of adaptive characteristics and employ a variety of strategies to cope with difficulties, and these are explored in detail. Exploring identity processes reveals that participants’ adaptation is aided by prior identification with UK and ‘Western culture’, which is understood as a reflection of the socio-economic changes taking place in Poland since 1989. Theoretical implications and relevance of the findings to the field of counselling psychology are considered and further areas of exploration are discussed.
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- 2012
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142. Understanding habitat co-occurrence and the potential for competition between native mammals and invasive wild pigs (Sus scrofa) at the northern edge of their range
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O'Brien, Paul, Vander Wal, Eric, Koen, Erin L., Brown, Carissa D., Guy, Jenn, van Beest, Floris M., and Brook, Ryan K.
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Swine ,Wildlife conservation ,Moose ,Deciduous forests ,White-tailed deer ,Zoology and wildlife conservation - Abstract
Invasive species are a major contributor to biodiversity loss worldwide. Wild pigs (Sus scrofa Linnaeus, 1758) are highly invasive in their introduced ranges; they modify habitat and threaten native species. As recent invaders in Canada, it is unknown what habitats wild pigs occupy at the northern edge of their range and how they affect mammalian diversity. We examined habitat factors that we predicted would affect co-occurrence of wild pigs with native mammals. We randomly placed 17 camera traps in four stratified habitat types (deciduous forest, grassland, cropland, and wetland) for 2 years to examine species co-occurrence in these habitats. We analyzed camera-trap data using nonmetric multidimensional scaling. Wild pig detection during winter was greatest in wetland and cropland and positively associated with occurrence of moose (Alces alces (Linnaeus, 1758)) and coyote (Canis latrans Say, 1823) and negatively associated with the presence of white-tailed deer (Odocoileus virginianus (Zimmermann, 1780)), mule deer (Odocoileus hemionus (Rafinesque, 1817)), and humans. In summer, we detected wild pigs only in grassland; these detections were positively associated with moose and mule deer and negatively associated with domesticated cattle (Bos taurus Linnaeus, 1758), elk (Cervus canadensis Erxleben, 1777), and humans. We conclude that invasive wild pig occurrence at the northern edge of their Canadian range varies seasonally, by habitat, and is negatively affected by the presence of humans. Moreover, apparent co-occurrence with native fauna and avoidance of domestic species provides early evidence for potential competitive interactions. Key words: habitat occurrence, Sus scrofa, wild pig, invasive species, community ecology, ordination, camera trap, Saskatchewan. Les especes envahissantes sont un important facteur de perte de biodiversite a l'echelle planetaire. Les sangliers (Sus scrofa Linnaeus, 1758) sont tres envahissants dans les aires où ils sont introduits; ils modifient les habitats et menacent les especes indigenes. Comme l'espece est un envahisseur recent au Canada, les habitats qu'elle occupe a la limite nord de son aire de repartition et son incidence sur la diversite des mammiferes ne sont pas connus. Nous avons examine des facteurs associes a l'habitat qui, selon nos predictions, auraient une incidence sur la cooccurrence des sangliers avec des mammiferes indigenes. Nous avons place aleatoirement 17 pieges photographiques dans quatre types d'habitats stratifies (foret de feuillus, prairie, terre cultivee et milieu humide) pendant 2 ans afin d'examiner la cooccurrence d'especes dans ces habitats. Nous avons analyse les donnees des pieges photographiques en utilisant une mise a l'echelle multidimensionnelle non metrique. Durant l'hiver, des sangliers etaient detectes le plus souvent dans les habitats de milieu humide et de terre cultivee et leur presence montrait une association positive avec celle de l'orignal (Alces alces (Linnaeus, 1758)) et du coyote (Canis latrans Say, 1823) et une association negative avec la presence de cerfs de Virginie (Odocoileus virginianus (Zimmermann, 1780)), de cerfs mulets (Odocoileus hemionus (Rafinesque, 1817)) et d'humains. En ete, des sangliers n'ont ete detectes que dans l'habitat de prairie, et ces detections etaient positivement associees a l'orignal et au cerf mulet et negativement associees aux bovins domestiques (Bos taurus Linnaeus, 1758), au wapiti (Cervus canadensis Erxleben, 1777) et aux humains. Nous en concluons que la presence de sangliers envahissants a la limite nord de leur aire de repartition canadienne varie selon la saison et l'habitat et que la presence d'humains a une incidence negative sur elle. En outre, sa cooccurrence apparente avec des animaux indigenes et l'evitement d'especes domestiques constitueraient les premiers indices de possibles interactions concurrentielles. [Traduit par la Redaction] Mots-cles : presence d'habitat, Sus scrofa, sanglier, espece envahissante, ecologie des communautes, ordination, piege photographique, Saskatchewan., Introduction Invasive species are considered a major threat to native species around the world. Few introduced species, however, can be considered responsible for species extinctions (Gurevitch and Padilla 2004). Wild [...]
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- 2019
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143. A Massive X-Ray Outflow from the Quasar PDS 456
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Reeves, James, O'Brien, Paul, and Ward, Martin
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Astrophysics - Abstract
We report on XMM-Newton spectroscopic observations of the luminous, radio-quiet quasar PDS 456. The hard X-ray spectrum of PDS 456 shows a deep absorption trough (constituting 50% of the continuum) at energies above 7 keV in the quasar rest frame, which can be attributed to a series of blue-shifted K-shell absorption edges due to highly ionized iron. The higher resolution soft X-ray RGS spectrum exhibits a broad absorption line feature near 1 keV, which can be modeled by a blend of L-shell transitions from highly ionized iron (Fe XVII-XXIV). An extreme outflow velocity of 50000 km/s is required to model the K and L shell iron absorption present in the XMM-Newton data. Overall, a large column density ($N_{H}=5\times10^{23}$cm$^{-2}$) of highly ionized gas (logxi=2.5) is required in PDS 456. A high mass outflow rate of 10 solar masses per year (assuming a conservative outflow covering factor of 0.1 steradian) is derived, which is of the same order as the overall mass accretion rate in PDS 456. The kinetic energy of the outflow represents a substantial fraction (10%) of the quasar energy budget, whilst the large column and outflow velocity place PDS 456 towards the extreme end of the broad absorption line quasar population., Comment: 13 pages, 3 figures. Accepted for publication in ApJ Letters
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- 2003
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144. Simulation and theory of liquid crystals
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O'Brien, Paul A.
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530.42 ,QC Physics - Abstract
We present a study of the theory and simulation of Liquid Crystals. A general introduction to the field is given, then the essential features of the Monte Carlo (MC) sampling algorithm are described and explained, along with some of the practical considerations in the implementation of MC. Several quantitative measures used to describe liquid crystalline systems are outlined, including the second rank order tensor, in addition to some of those from elastic theory and density functional theory. Monte Carlo Simulations were performed in bulk geometry in the canonical ensemble in order to calculate the Frank elastic constants of hard spherocylinders, hard platelets and hard cut-spheres at three thicknesses. Onsager’s density functional theory was also performed to yield the elastic constants for hard platelets, and this amounts to using a virial expansion in the free energy, truncated at second order. Our collaborators for O’Brien et al. [2008] provided results for the elastic constants from a calculation of the higher order virial coefficients. All of the results from theory are compared to simulation, with some experimental determinations available. All three elastic constants compared well with the high-order virial theory, there is quantitative agreement with the experimental values, and the effect of increasing thickness of discs was found to improve the agreement of the ratio of K1/K3. Aspects of translationally ordered phases are studied in the context of constrained non-equilibrium systems. Monte Carlo was also performed for platelets confined in wedge geometry, with several choices for the types of wall. A local approximation is utilised to yield the depletion force and potential as a function of the wall separation, as well as the adsorption between the walls. The adsorption for large separations exhibited general qualitative agreement with theory and Gibbs Ensemble simulations. The two different wall boundary conditions produced different orientational structural features, with repulsive and attractive depletion potentials measured, and a planar surface phase that does not appear in the bulk is categorised.
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- 2010
145. A Facile Green Synthesis of Ultranarrow PbS Nanorods
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Saah, Selina Ama, Khan, Malik Dilshad, Awudza, Johannes A. M., Revaprasadu, Neerish, and O’Brien, Paul
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- 2019
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146. Tailoring Shape and Crystallographic Phase of Copper Sulfide Nanostructures Using Novel Thiourea Complexes as Single Source Precursors
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Ketchemen, Kevin I. Y., Khan, Malik D., Mlowe, Sixberth, Nyamen, Linda D., Ndifon, Peter T., O’Brien, Paul, and Revaprasadu, Neerish
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- 2019
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147. Chemical vapor deposition of tin sulfide from diorganotin(IV) dixanthates
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Al-Shakban, Mundher, Matthews, Peter D., Lewis, Edward A., Raftery, James, Vitorica-Yrezabal, Inigo, Haigh, Sarah J., Lewis, David J., and O’Brien, Paul
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- 2019
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148. Long-Term Outcomes After Bariatric Surgery: a Systematic Review and Meta-analysis of Weight Loss at 10 or More Years for All Bariatric Procedures and a Single-Centre Review of 20-Year Outcomes After Adjustable Gastric Banding
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O’Brien, Paul E., Hindle, Annemarie, Brennan, Leah, Skinner, Stewart, Burton, Paul, Smith, Andrew, Crosthwaite, Gary, and Brown, Wendy
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- 2019
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149. The Remarkably Featureless High Resolution X-ray Spectrum of Mrk 478
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Marshall, Herman L., Edelson, Rick A., Vaughan, Simon, Malkan, Mathew A., O'Brien, Paul, and Warwick, Robert
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Astrophysics - Abstract
An observation of Mrk 478 using the Chandra Low Energy Transmission Grating Spectrometer is presented. The source exhibited 30-40% flux variations on timescales of order 10000 s together with a slow decline in the spectral softness over the full 80 ks observation. The 0.15--3.0 keV spectrum is well fitted by a single power law with photon index of Gamma = 2.91 +/- 0.03. Combined with high energy data from BeppoSAX, the spectrum from 0.15 to 10 keV is well fit as the sum of two power laws with Gamma = 3.03 +/- 0.04, which dominates below 2 keV and 1.4 +/- 0.2, which dominates above 2 keV (quoting 90% confidence uncertainties). No significant emission or absorption features are detected in the high resolution spectrum, supporting our previous findings using the Extreme Ultraviolet Explorer but contradicting the claims of emission lines by Hwang & Bowyer (1997). There is no evidence of a warm absorber, as found in the high resolution spectra of many Sy 1 galaxies including others classified as narrow line Sy 1 galaxies such as Mrk 478. We suggest that the X-ray continuum may result from Comptonization of disk thermal emission in a hot corona through a range of optical depths., Comment: 21 pages, 7 figures; accepted for publication in the Astronomical Journal
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- 2002
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150. An XMM-Newton observation of the luminous Seyfert 1 galaxy Markarian 509
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Pounds, Ken, Reeves, James, O'Brien, Paul, Page, Kim, Turner, Martin, and Nayakshin, Sergei
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Astrophysics - Abstract
We present the spectral analysis of an early XMM-Newton observation of the luminous Seyfert 1 galaxy Markarian 509. We find the hard (2-10 keV) continuum slope, including reflection, to be somewhat flatter ($\Gamma=1.75$) than for a typical BLS1. The most obvious feature in the hard X-ray spectrum is a narrow emission line near 6.4 keV, with an equivalent width of 50 eV. The energy and strength of this line is consistent with fluorescence from `neutral' iron in the molecular torus, and we note the emerging ubiquity of this feature in XMM-Newton and Chandra observations of Seyfert 1 galaxies over a wide luminosity range. We also find evidence for a second emission line at 6.7-6.9 keV, which we attempt to model by reflection from a highly ionised disc. A `soft excess', evident as an upward curvature in the continuum flux below 1.5 keV, cannot be explained solely by enhanced reflection from the ionised disc. The RGS spectrum shows only weak discrete emission and absorption features in the soft X-ray spectrum, supporting our conclusion that the soft excess emission in Mkn 509 represents the high energy portion of optically thick, thermal emission from the inner accretion disc., Comment: 16 pages, including postscript figures. Accepted for Publication in ApJ
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- 2001
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