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630 results on '"Ohya Y"'

103. PP104. Pregnancy-induced hypertension is a strong risk factor for hypertension just 5 years after delivery: A double cohort study at the National Center for Child Health and Development and Showa University Hospital, Tokyo

Author

Mito, A., primary, Arata, N., additional, Jwa, S.C., additional, Sakamoto, N., additional, Qiu, D., additional, Murashima, A., additional, Ichihara, A., additional, Matsuoka, R., additional, Sekizawa, A., additional, Ohya, Y., additional, and Kitagawa, M., additional

Published
2012
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110. Inhibitory action of betaxolol, a beta 1-selective adrenoceptor antagonist, on voltage-dependent calcium channels in guinea-pig artery and vein

Author

Setoguchi, M., Ohya, Y., Abe, I., and Fujishima, M.

Subjects
Dose-Response Relationship, Drug, Nifedipine, Portal Vein, Guinea Pigs, Electric Conductivity, In Vitro Techniques, Calcium Channel Blockers, Muscle, Smooth, Vascular, Betaxolol, Mesenteric Arteries, Diltiazem, Animals, Female, Research Article
Abstract

1. The effects of betaxolol, (+/-)-1-[4-[2-(cyclopropylmethoxy) ethyl] phenoxy]-3-(isopropylamino)-2-propanol hydrochloride, a beta 1-selective adrenoceptor antagonist, on voltage-dependent Ca2+ channels were investigated in single smooth muscle cells from guinea-pig mesenteric artery and portal vein using a whole-cell variant of the patch-clamp technique. Ca2+ channel currents were recorded with bath solutions contained 10 mM Ba2+ for arterial cells and 2 mM Ca2+ for venous cells. 2. Betaxolol inhibited Ca2+ channel currents dose-dependently in both mesenteric artery cells and portal vein cells. The two isomers, (+)-betaxolol and (-)-betaxolol (relative beta-antagonistic efficacies of 0.1 and 1, respectively), had similar potencies for inhibiting Ca2+ channel currents in portal vein cells. Propranolol did not inhibit the currents. Thus the inhibitory action of betaxolol on Ca2+ channel currents was independent of the beta-adrenoceptor. 3. The inhibitory action of betaxolol on Ca2+ channel currents was compared with that of diltiazem and of nifedipine in mesenteric artery cells. The current inhibition depended on the stimulation frequency with all drugs (use-dependent block). All drugs also accelerated the current decay and shifted the voltage-dependent inactivation curve in a negative direction. 4. In conclusion, betaxolol inhibited Ca2+ channel currents in vascular smooth muscle cells. The mode of inhibitory action was similar to that of diltiazem and nifedipine. Our results suggest that betaxolol is a unique beta-adrenoceptor antagonist that has a direct inhibitory action on voltage-dependent Ca2+ channels in vascular smooth muscle cells.

Published
1995

113. Amyloid turnover after liver transplantation in FAP

Author

Obayashi, K., primary, Ueda, M., additional, Jono, H., additional, Yamashita, T., additional, Yazaki, M., additional, Kametani, F., additional, Ohya, Y., additional, Inomata, Y., additional, Ikeda, S., additional, and Ando, Y., additional

Published
2011
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131. G.P.12.06 Resting energy expenditure and nutritional inadequacy in Duchenne muscular dystrophy

Author

Komaki, H., primary, Shimizu, M., additional, Nakagawa, E., additional, Yoshimura, M., additional, Ohya, Y., additional, Fujisaki, T., additional, Saida, Y., additional, Kubota, C., additional, Itoh, S., additional, Shimazaki, R., additional, Sato, K., additional, Ishikawa, T., additional, Mochizuki, H., additional, Takanoha, T., additional, Konagaya, M., additional, Miyazaki, T., additional, and Tatara, K., additional

Published
2008
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143. Total serum Ig E level influences oral food challenge tests for Ig E-mediated food allergies.

Author

Horimukai, K., Hayashi, K., Tsumura, Y., Nomura, I., Narita, M., Ohya, Y., Saito, H., and Matsumoto, K.

Subjects
IMMUNOGLOBULIN E, FOOD allergy, LOGISTIC regression analysis, ENZYME-linked immunosorbent assay, RECEIVER operating characteristic curves
Abstract

Probability curves predicting oral food challenge test ( OFC) results based on specific IgE levels are widely used to prevent serious allergic reactions. Although several confounding factors are known to affect probability curves, the main factors that affect OFC outcomes are currently unclear. We hypothesized that an increased total IgE level would reduce allergic reactivity. Medical records of 337 and 266 patients who underwent OFCs for 3.5 g boiled hen's egg white and 3.1 ml raw cow's milk, respectively, were examined retrospectively. We subdivided the patients into three groups based on total IgE levels and age by percentile (<25th, 25-75th, and >75th percentiles), and logistic regression analyses were performed on each group. Patients with higher total IgE levels were significantly less responsive. In addition, age did not significantly affect the OFC results. Therefore, total IgE levels should be taken into account when predicting OFC results based on food-specific IgE levels. [ABSTRACT FROM AUTHOR]

Published
2015
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148. Impaired Quality of Life in Child Asthmatics in Tokyo, Japan

Author

Kojima, N., primary, Ohya, Y., additional, Futamura, M., additional, Akashi, M., additional, Akiyama, K., additional, Takahashi, K., additional, Nakagawa, T., additional, Kobayashi, F., additional, Eboshida, A., additional, Nakamura, H., additional, Odajima, H., additional, Adachi, Y., additional, and Akasawa, A., additional

Published
2006
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