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Global concern over widely documented declines in pollinators.sup.1-3 has led to the identification of anthropogenic stressors that, individually, are detrimental to bee populations.sup.4-7. Synergistic interactions between these stressors could substantially amplify the environmental effect of these stressors and could therefore have important implications for policy decisions that aim to improve the health of pollinators.sup.3,8,9. Here, to quantitatively assess the scale of this threat, we conducted a meta-analysis of 356 interaction effect sizes from 90 studies in which bees were exposed to combinations of agrochemicals, nutritional stressors and/or parasites. We found an overall synergistic effect between multiple stressors on bee mortality. Subgroup analysis of bee mortality revealed strong evidence for synergy when bees were exposed to multiple agrochemicals at field-realistic levels, but interactions were not greater than additive expectations when bees were exposed to parasites and/or nutritional stressors. All interactive effects on proxies of fitness, behaviour, parasite load and immune responses were either additive or antagonistic; therefore, the potential mechanisms that drive the observed synergistic interactions for bee mortality remain unclear. Environmental risk assessment schemes that assume additive effects of the risk of agrochemical exposure may underestimate the interactive effect of anthropogenic stressors on bee mortality and will fail to protect the pollinators that provide a key ecosystem service that underpins sustainable agriculture. A meta-analysis of studies in which bees were exposed to combinations of agrochemicals, nutritional stressors and/or parasites revealed evidence for synergistic effects on mortality when bees were exposed to multiple agrochemicals at field-realistic levels., Author(s): Harry Siviter [sup.1] [sup.2] , Emily J. Bailes [sup.1] [sup.3] [sup.4] , Callum D. Martin [sup.1] , Thomas R. Oliver [sup.1] [sup.4] [sup.5] , Julia Koricheva [sup.1] , Ellouise [...]

Light-harvesting complex II (LHCII) serves a central role in light harvesting for oxygenic photosynthesis and is arguably the most important photosynthetic antenna complex. In this work, we present two-dimensional electronic-vibrational (2DEV) spectra of LHCII isolated from spinach, demonstrating the possibility of using this technique to track the transfer of electronic excitation energy between specific pigments within the complex. We assign the spectral bands via comparison with the 2DEV spectra of the isolated chromophores, chlorophyll a and b, and present evidence that excitation energy between the pigments of the complex are observed in these spectra. Finally, we analyze the essential components of the 2DEV spectra using singular value decomposition, which makes it possible to reveal the relaxation pathways within this complex.

In this article I describe the contributions made by Samuel Alexander to the issue of relations which so vexed Bertrand Russell and F. H. Bradley in the late nineteenth and early twentieth centuries. I provide a novel understanding of Alexander's position concerning relations and describe the way in which he viewed his position as superior to those of Bradley and Russell. I offer, therefore, a more complete picture of a philosophical debate central to the relevant period, through the introduction of a third character whose views have been largely omitted from available narratives. [ABSTRACT FROM AUTHOR]

In this discussion I argue that Peter Sullivan is wrong to suggest that Wittgenstein's position in the Philosophical Investigations involves a commitment to transcendental idealism. I show that Sullivan's interpretation involves holding that transcendental idealism was employed by Wittgenstein in the attempt to combat a Platonist mythology. I show, through a detailed appraisal of Wittgenstein's discussion of samples, that Wittgenstein's approach to Platonism does not involve any such employment of transcendental idealism. I conclude that there is no such motivation as Sullivan finds in Wittgenstein for endorsing transcendental idealism, and that we ought not, therefore, ascribe to him such a view. [ABSTRACT FROM AUTHOR]

Background: Hospital discharge summaries play an essential role in informing GPs of recent admissions to ensure excellent continuity of care and prevent adverse events; however, they are notoriously poorly written, time-consuming, and can result in delayed discharge. Aim: To evaluate the potential of artificial intelligence (AI) to produce high-quality discharge summaries equivalent to the level of a doctor who has completed the UK Foundation Programme. Design & setting: Feasibility study using 25 mock patient vignettes. Method: Twenty-five mock patient vignettes were written by the authors. Five junior doctors wrote discharge summaries from the case vignettes (five each). The same case vignettes were input into ChatGPT. In total, 50 discharge summaries were generated; 25 by Al and 25 by junior doctors. Quality and suitability were determined through both independent GP evaluators and adherence to a minimum dataset. Results: Of the 25 AI-written discharge summaries 100% were deemed by GPs to be of an acceptable quality compared with 92% of the junior doctor summaries. They both showed a mean compliance of 97% with the minimum dataset. In addition, the ability of GPs to determine if the summary was written by ChatGPT was poor, with only a 60% accuracy of detection. Similarly, when run through an AI-detection tool all were recognised as being very unlikely to be written by AI. Conclusion: AI has proven to produce discharge summaries of equivalent quality to a junior doctor who has completed the UK Foundation Programme; however, larger studies with real-world patient data with NHS-approved AI tools will need to be conducted. [ABSTRACT FROM AUTHOR]