1,153 results on '"Omma A"'
Search Results
102. Evaluation and follow-up data of patients diagnosed with hypophysitis: A multicentric nationwide study
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Aysa Hacioglu, Zuleyha Karaca, Serhat Uysal, Hande Mefkure Ozkaya, Pinar Kadioglu, Ozlem Soyluk Selcukbiricik, Sema Yarman, Nurdan Gul, Damla Koksalan, Alev Selek, Berrin Cetinarslan, Zeynep Canturk, Şah unal Fatma Tuğce, Demet Corapcıoğlu, Mustafa Sahin, Afruz Babayeva, Mujde Akturk, Ayten Eraydin, Semin Fenkci, Hamide Piskinpasa, Sema Ciftci, Meric Dokmetaş, Onur Şahin, Dokmetas H. Sebile, Sadettin Ozturk, Ersin Akarsu, Kan Elif Kılıc, Aysegul Atmaca, Esma Pehlivan, Fusun Saygili, Buruc Erkan, Sebnem Burhan, Tulay Omma, Ziynet Alphan Uc, Gulsah Elbuken, Fahri Bayram, Goknur Yorulmaz, Guven Baris Cansu, Hayri Bostan, Kubra Turan, Selcuk Yusuf Sener, Suheyla Gorar, Zafer Pekkolay, Zeliha Hekimsoy, Hakan Dogruel, Melek Eda Ertorer, Omercan Topaloğlu, Ozlem Celik, Ozlem Iyidir, and Fahrettin Kelestimur more...
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General Medicine - Published
- 2023
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103. The relationship between steroidogenesis and healthy eating index in polycystic ovary syndrome
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Tulay Omma, Yucel Cigdem, Murat Kızılgun, Coskun Seyma Osmanlıoglu, Zengin Fatmanur Humeyra, and Cavit Culha
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General Medicine - Published
- 2023
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104. The Reassessment of Therapeutic Decisions by Clinicians According to the SAGIT® Instrument in Acromegaly: Results of a Multicenter Study
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Seda Turgut, Sema Ciftci, Nusret Yilmaz, Serhat Uysal, İlkin Muradov, Kan Elif Kılıc, Guven Baris Cansu, Yalın Gulşah Yenidunya, Ziynet ALphan Uc, Goktuğ Sarıbeyliler, Esma Pehlivan, Gulay Simsek Bagir, Seher Tanrikulu, Guzin Yaylali, Fuat Mısıroğlu, Tulay Omma, Ozlem Soyluk Selcukbiricik, İlkay Cakir, Banu Sarer Yurekli, Melek Eda Ertorer, Pinar Kadioglu, Fusun Saygili, and Sema Yarman more...
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General Medicine - Published
- 2023
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105. A case with late-onset Ornithine Transcarbamylase Deficiency as a possible cause of osteoporosis
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Sena İlin, Serife Mehlika Kuskonmaz, Gonul Koc, Sevde Nur Fırat, Tulay Omma, and Cavit Culha
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General Medicine - Published
- 2023
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106. Achilles tendon rupture in an uncontrolled diabetes patient
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Şerife Ezgi Doğan, Serife Mehlika Kuskonmaz, Gonul Koc, Tulay Omma, Sevde Nur Firat, and Cavit Culha
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General Medicine - Published
- 2023
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107. Comprehensive Policy-Brief to the EU Commission: Roadmap to Decolonial Arctic Research
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Herrmann, T., Brunner Alfani, F., Chahine, A., Döring, N., Dudeck, S., Elster, J., Fjellheim, E., Henriksen, J., Hermansen, N., Holmberg, A., Kramvig, B., Keskitalo, A., Omma, E., Saxinger, G., Scheepstra, A., and van der Schot, J. more...
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The "Comprehensive Policy Brief to the EU Commission - Roadmap to Decolonial Arctic Research" is an evidence-based tool for achieving decolonial innovation in methodology and funding mechanisms in the Arctic research landscape, including the natural and social sciences and the humanities. In four concise chapters, the group of experts, consisting of Indigenous and non-Indigenous researchers and Indigenous rights holders, 1) guide the readership through the legal and political dimensions as well as that of research innovation and paradigmatic shifts in Arctic research; 2) it offers concrete methodological considerations in carrying out projects; 3) it elaborates on the participation of Indigenous rights holders in the EU research funding structures from a practice perspective. 4) it outlines the benefits of Indigenous-led Arctic research and of funding co-creative projects. This Roadmap can support the mainstreaming of co-creative and collaborative principles and equal partnership by Indigenous and non-Indigenous actors in 1) large-scale research projects, 2) calls for projects, 3) proposal design and project evaluation, and 4) in the implementation of the European Polar Research Program. At the international level, the rights of Indigenous Peoples have been receiving increasing legal recognition. Similarly, EU calls-for-proposals ask nowadays increasingly for a ‘co-design approach’ in research (e.g., in the past Horizon 2020, and the current Horizon Europe funding schemes). Arctic researchers are increasingly adopting decolonial research approaches. Yet implementing decolonial research practices as new standards and taking initiative that supports Indigenous sovereignty in the Arctic is often still lacking. Therefore, theoretical and methodological expertise about co-creation of knowledge, as offered in this Roadmap, can help to foster capacity among researchers in all disciplines (natural and social sciences, the humanities) and among the relevant funding bodies such as the EU Commission and the large variety of international and national funding organisations. more...
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- 2023
108. The Importance of Eurekan Mountains on Cenozoic Sediment Routing on the Western Barents Shelf
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Flowerdew, Michael J., Fleming, Edward J., Chew, David M., Morton, Andrew C., Frei, Dirk, Benedictus, Aukje, Omma, Jenny, Riley, Teal. R., Badenszki, Eszter, Whitehouse, Martin J., Flowerdew, Michael J., Fleming, Edward J., Chew, David M., Morton, Andrew C., Frei, Dirk, Benedictus, Aukje, Omma, Jenny, Riley, Teal. R., Badenszki, Eszter, and Whitehouse, Martin J. more...
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The importance of topography generated by Eocene Eurekan deformation as a sediment source for sandstones deposited on the western Barents Shelf margin is evaluated through a sediment provenance study conducted on wellbore materials retrieved from Spitsbergen and from the Vestbakken Volcanic Province and the Sørvestsnaget Basin in the southwest Barents Sea. A variety of complementary techniques record a provenance change across the Paleocene-Eocene boundary in wellbore BH 10-2008, which samples Paleogene strata of the Central Tertiary Basin in Spitsbergen. Sandstones containing K-feldspar with radiogenic Pb isotopic compositions, chrome spinel in the heavy mineral assemblage, and detrital zircons and rutiles with prominent Palaeoproterozoic and Late Palaeozoic—Early Mesozoic U-Pb age populations are up-section replaced by sandstone containing albitic plagioclase feldspar, metasedimentary schist rock fragments, a heavy mineral assemblage with abundant chloritoid, metamorphic apatite with low REE contents, metapelitic rutile with Silurian U-Pb ages and zircons with predominantly Archaean and Palaeoproterozoic U-Pb age populations. Our results clearly demonstrate the well-known regional change in source area from an exposed Barents Shelf terrain east of the Central Tertiary Basin during the Paleocene to the emerging Eurekan mountains west and north of the Central Tertiary Basin during the Eocene. Eocene sandstones deposited in the marginal basins of the southwestern Barents Shelf, which were sampled in wellbores 7316/5-1 and 7216/11-1S, contain elements of both the Eurekan and the eastern Barents Shelf provenance signatures. The mixing of the two sand types and delivery to the southwest margin of the Barents Shelf is consistent with a fill and spill model for the Central Teritary Basin, with transport of Eurekan-derived sediment east then south hundreds of kilometres across the Shelf. more...
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- 2023
109. A multi-proxy provenance study of Late Carboniferous to Middle Jurassic sandstones in the Eastern Sverdrup Basin and its bearing on Arctic palaeogeographic reconstructions
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Pointon, Michael A., Smyth, Helen, Omma, Jenny E., Morton, Andrew C., Schneider, Simon, Hülse, Peter, Rippington, Stephen J., Lopez-Mir, Berta, Crowley, Quentin G., Millar, Ian, Whitehouse, Martin J., Frei, Dirk, Scott, Robert A., Flowerdew, Michael J., Pointon, Michael A., Smyth, Helen, Omma, Jenny E., Morton, Andrew C., Schneider, Simon, Hülse, Peter, Rippington, Stephen J., Lopez-Mir, Berta, Crowley, Quentin G., Millar, Ian, Whitehouse, Martin J., Frei, Dirk, Scott, Robert A., and Flowerdew, Michael J. more...
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A multi-proxy provenance study of Late Carboniferous to Middle Jurassic sandstones from the eastern Sverdrup Basin was undertaken employing optical petrography and heavy mineral analysis, chemical analysis of apatite, garnet and rutile grains, as well as detrital zircon U–Pb geochronology and Hf isotope analysis. Late Carboniferous to Middle Jurassic strata on the southern basin margin are inferred as being predominantly reworked from Silurian to Devonian strata within the adjacent Franklinian Basin succession. Higher-grade metamorphic detritus appeared during Middle to Late Triassic times and indicates exhumation and erosion of lower (Neoproterozoic to Cambrian) levels within the Franklinian Basin succession and/or a direct detrital input from the Canadian-Greenland Shield. The provenance of northern-derived sediments is more enigmatic owing to the subsequent opening of the Arctic Ocean. Northern-derived Middle Permian to Early Triassic sediments were likely derived from proximal areas of the Chukotkan part of the Arctic Alaska-Chukotka microplate. Late Triassic northern-derived sediments have different detrital zircon U–Pb age spectra from Middle Permian to Early Triassic ones and were likely derived from the Uralian orogenic belt and/or the Arctic Uralides. The loss of this sand input during latest Triassic times is interpreted to reflect drainage reorganisation farther upstream on the Barents Shelf. Middle Jurassic sands in the northern and axial parts of the basin were largely reworked from local northern-derived Late Triassic strata. This may have been facilitated by rift flank uplift of the northern basin margin in response to rifting in the adjacent proto-Amerasia Basin. more...
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- 2023
110. Towards Arctic Research Upholding Indigenous Peoples’ Rights:Recommendations for ICARP IV, the International Conference on Arctic Research Planning
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Holmberg, Aslak, Morin, Evie, Chahine, Anne S., Doering, Nina N., Dudeck, Stephan, Fisher, Charleen, Hermansen, Nina, Herrmann, Thora Martina, Ikaarvik, Kramvig, Britt, Omma, Elle Merete, Riedel, Arne, Saxinger, Gertrude, Scheepstra, Annette J.M., van der Schot, Jorrit, Holmberg, Aslak, Morin, Evie, Chahine, Anne S., Doering, Nina N., Dudeck, Stephan, Fisher, Charleen, Hermansen, Nina, Herrmann, Thora Martina, Ikaarvik, Kramvig, Britt, Omma, Elle Merete, Riedel, Arne, Saxinger, Gertrude, Scheepstra, Annette J.M., and van der Schot, Jorrit more...
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Contemporary Arctic research frequently perpetuates colonial injustices against local Indigenous communities. A team of researchers, including scientists from the Research Institute for Sustainability – Helmholtz Centre Potsdam, have published a policy brief with recommendations aimed at upholding the rights of Indigenous Peoples and fostering the parity and complementarity of Traditional Knowledge, Indigenous Knowledge, and academic scientific knowledge. The policy brief is a contribution to the International Arctic Science Committee’s multi-year planning process for the Fourth International Conference on Arctic Research Planning. more...
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- 2023
111. The relationship between nutrition, inflammation and colchicine resistance in familial Mediterranean fever
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Tülay OMMA, Seda ÇOLAK, Sevinç CAN SANDIKÇI, Fatmanur Hümeyra ZENGİN, and Ahmet OMMA
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Health Care Sciences and Services ,Sağlık Bilimleri ve Hizmetleri ,Familial Mediterranean fever ,inflammation ,nutrition ,colchicine resistance ,dietary inflammatory index - Abstract
Aim: Familial Mediterranean fever (FMF) is an autoinflammatory and genetic disease associated with chronic inflammation. Colchicine is the gold standard treatment for FMF, although some patients respond partially. Factors such as heavy exercise, cold exposure, stress, recent infection or surgery have been associated with the occurrence of attacks. Recently, nutrition is thought to be involved in the pathogenesis of autoimmune and autoinflammatory diseases. Therefore, we aimed to investigate the relationship between nutrition, inflammation and colchicine resistance by considering the nutritional status of FMF patients. Material and Method: The study included 59 patients and 67 healthy individuals who were matched for gender, age and body mass index (BMI). Clinical, anthropometric, and biochemical measurements were obtained. Three-days, 24-hour diet records were recorded in the nutrient database program (BeBiS software program), the amounts of macro and micronutrient contents were determined and the Diet Inflammatory Index (DII) score was calculated and compared between groups. Results: Statistically, the diets of FMF patients were found to be higher in omega-6, carbohydrate percentage and salt content, and lower in terms of lactose, fat percentage, monounsaturated fatty acids, retinol and biotin compared to controls. There was no correlation between DII and acute phase reactants and colchicine dose. Conclusion: The course of FMF can be affected by environmental factors, as well as its genetic background. Nutrition is a new and interesting topic in this regard and may contribute to inflammation and disease activity in FMF patients. more...
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- 2022
112. Clinical characteristics and disease course before and after SARS-CoV-2 infection in a large cohort of systemic sclerosis patients.
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AVANOGLU GÜLER, Aslıhan, ÖZÇİMEN, Büşra, AYDOĞDU, Mesude Seda, SARI, Alper, NUMUNE, Aliyeva, ERSAN, Nazife TÜZÜN, ÇOLAK, Seda, KARADENİZ, Hazan, VASİ, İbrahim, KÜÇÜK, Hamit, YALÇINKAYA, Yasemin, ERDEN, Abdülsamet, KAYAALP, Mehmet, ÖZTÜRK, Mehmet Akif, GÖKER, Berna, OMMA, Ahmet, YILMAZ, Sedat, KOCA, Süleyman Serdar, İNANÇ, Murat, and AKDOĞAN, Ali more...
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SYSTEMIC scleroderma ,COVID-19 ,SARS-CoV-2 ,DISEASE progression ,INTERSTITIAL lung diseases ,COUGH - Abstract
Background/aim: The objective of this study is to evaluate the clinical presentations and adverse outcomes of Coronavirus Disease 2019 (COVID-19) in patients with systemic sclerosis (SSc) and assess the impact of SSc features on the clinical course of COVID-19. Materials and methods: In this multicenter, retrospective study, SSc patients with COVID-19 were included. Clinical features of SSc, along with detailed COVID-19 data, were extracted from medical records and patient interviews. Results: The study included 112 patients (mean age 51.4 ± 12.8 years; 90.2% female). SSc-associated interstitial lung disease (ILD) was evident in 57.1% of the patients. The findings revealed hospitalization in 25.5%, respiratory support in 16.3%, intensive care unit admission in 3.6%, and a mortality rate of 2.7% among SSc patients with COVID-19. Risk factors for respiratory failure, identified through univariate analysis, included ILD (OR: 7.49, 95% CI: 1.63-34.46), =1 comorbidity (OR: 4.55, 95% CI: 1.39-14.88), a higher physician global assessment score at the last outpatient visit (OR 2.73, 95% CI: 1.22-6.10), and the use of mycophenolate at the time of infection (OR: 5.16, 95 %CI: 1.79-14.99). Notably, =1 comorbidity emerged as the sole significant predictor of the need for respiratory support in COVID-19 (OR: 5.78, 95% CI: 1.14-29.23). In the early post-COVID-19 period, 17% of patients reported the progression of the Raynaud phenomenon, and 10.6% developed new digital ulcers. Furthermore, progression or new onset of dyspnea and cough were detected in 28.3% and 11.4% of patients, respectively. Conclusion: This study suggests a potential association between adverse outcomes of COVID-19 and SSc-related ILD, severe disease activity, and the use of mycophenolate. Additionally, it highlights that having comorbidities is an independent risk factor for the need for respiratory support in COVID-19 cases. [ABSTRACT FROM AUTHOR] more...
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- 2024
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113. Coronavirus Disease 2019 Outcomes in Amyloid A Protein Amyloidosis Secondary to Rheumatic Conditions and Signs of Post-Coronavirus Disease 2019 Proteinuria Progression.
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Güven, Serdar Can, Erden, Abdulsamet, Küçük, Hamit, Apaydın, Hakan, Polat, Bünyamin, Kardaş, Rıza Can, Yıldırım, Derya, Usul, Eren, Armağan, Berkan, Küçükşahin, Orhan, Omma, Ahmet, and Tufan, Abdurrahman more...
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SARS-CoV-2 ,COVID-19 pandemic ,COVID-19 ,AMYLOIDOSIS ,CHRONIC kidney failure - Abstract
Background: We aimed to investigate coronavirus diease 2019 (COVID-19) outcomes in patients with amyloid A protein (AA) amyloidosis secondary to rheumatic diseases and discuss factors associated with disease course. Methods: A retrospective cohort was formed from adult patients with a diagnosis of AA amyloidosis. In patients with a positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction (PCR) test, rates of hospitalization, intensive care unit admission and mortality due to COVID-19 were collected from medical records. Data regarding to demographics, comorbidities, laboratory tests, medical treatments, adherence to previous treatments during COVID-19 and treatment administered for COVID-19 were collected from hospital databases and patient reviews. Results: In 96 patients with AA amyloidosis, 16 had COVID-19 with a positive PCR. Ten (62.5%) patients were hospitalized, 2 (12.5%) were admitted to ICU, 1 (6.25%) was died. Hospitalized patients tended to be older. Comorbidities seemed to be more frequent in hospitalized patients. None of the patients had rapid progression to end-stage renal disease post-COVID-19. Seven patients had pre-COVID-19 and post-COVID-19 proteinuria levels. Three had notable increase in proteinuria after COVID-19 in 2 of which amyloidosis treatment was revised accordingly. Conclusion: Despite high rates of hospitalization in AA amyloidosis patients, mortality was observed only in 1 patient. Progression of proteinuria requiring treatment adjustment may be an issue in these patients. [ABSTRACT FROM AUTHOR] more...
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- 2024
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114. Investigating the impact of a pharmacist intervention on inappropriate prescribing practices at hospital admission and discharge in older patients: a secondary outcome analysis from a randomized controlled trial.
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Garcia, Beate Hennie, Omma, Katharina Kaino, Småbrekke, Lars, Johansen, Jeanette Schultz, Skjold, Frode, and Halvorsen, Kjell Hermann
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- 2024
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115. Diyabetik Kadınlarda Serum Hem Oksijenaz-1 (Ho-1) Enziminin Glisemik Kontrol ile İlişkisi.
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SAĞLAM, Osman, GÜLÇELİK, Neşe ERSÖZ, OMMA, Tülay, KARACA, Anara, ARAL, Yalçın, and GÜRSOY, Gül
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HEME oxygenase ,GLYCEMIC control ,PEOPLE with diabetes ,OXIDATIVE stress ,APOPTOSIS - Published
- 2024
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116. Semaphorin 3A levels in vascular and nonvascular phenotypes in systemic sclerosis.
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Kayaalp, Mehmet, Erden, Abdulsamet, Apaydin, Hakan, Güven, Serdar Can, Armağan, Berkan, Cağlayan Kayaalp, Merve, Andac Uzdogan, Esma, Enli, Şeymanur Ala, Omma, Ahmet, and Kucuksahin, Orhan more...
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PROTEINS ,BIOMARKERS ,SYSTEMIC scleroderma ,CASE-control method ,DESCRIPTIVE statistics ,PHENOTYPES - Abstract
Objective Semaphorin 3A (Sema3A) plays a regulatory role in immune responses. The aim of this study was to evaluate Sema3A levels in patients with systemic sclerosis (SSc), especially in major vascular involvements such as digital ulcer (DU), scleroderma renal crisis (SRC), pulmonary arterial hypertension (PAH), and to compare Sema3A level with SSc disease activity. Methods In SSc patients, patients with DU, SRC, or PAH were grouped as major vascular involvements and those without as nonvascular, and Sema3A levels were compared between the groups and with a healthy control group. The Sema3A levels and acute phase reactants in SSc patients, as well as their association with the Valentini disease activity index and modified Rodnan skin score, were evaluated. Results The Sema3A values (mean ± SD) were 57.60 ± 19.81 ng/mL in the control group (n = 31), 44.32 ± 5.87 ng/mL in patients with major vascular involvement SSc (n = 21), and 49.96 ± 14.00 ng/mL in the nonvascular SSc group (n = 35). When all SSc patients were examined as a single group, the mean Sema3A value was significantly lower than controls (P = .016). The SSc with major vascular involvement group had significantly lower Sema3A levels than SSc with nonmajor vascular involvement group (P = .04). No correlation was found between Sema3A, acute phase reactants, and disease activity scores. Also, no relationship was observed between Sema3A levels and diffuse (48.36 ± 11.47 ng/mL) or limited (47.43 ± 12.38 ng/mL) SSc types (P = .775). Conclusion Our study suggests that Sema3A may play a significant role in the pathogenesis of vasculopathy and can be used as a biomarker in SSc patients with vascular complications such as DU and PAH. [ABSTRACT FROM AUTHOR] more...
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- 2023
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117. Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study
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Batman, Adnan, primary, Yazici, Dilek, additional, Dikbas, Oguz, additional, Agbaht, Kemal, additional, Saygili, Emre Sedar, additional, Demirci, Ibrahim, additional, Bursa, Nurbanu, additional, Ayas, Görkem, additional, Anıl, Cüneyd, additional, Cesur, Mustafa, additional, Korkmaz, Fatma Nur, additional, Bahçecioglu, Adile Begüm, additional, Corapcıoglu, Demet, additional, Erdogan, Murat Faik, additional, Bostan, Hayri, additional, Calapkulu, Murat, additional, Hepsen, Sema, additional, Ucan, Bekir, additional, Cakal, Erman, additional, Guler, Bagdagul Yuksel, additional, Haymana, Cem, additional, Ipekci, Suleyman Hilmi, additional, Aydın, Selami, additional, Sezer, Havva, additional, Ozısık, Seçil, additional, Deyneli, Oguzhan, additional, Alagol, Faruk, additional, Tanakol, Refik, additional, Eroglu, Mustafa, additional, Mutlu, Ummu, additional, Hacisahinogullari, Hulya, additional, Uzum, Ayse Kubat, additional, Demir, Canan, additional, Koç, Gonul, additional, Fırat, Sevde Nur, additional, Omma, Tulay, additional, Ince, Nurcan, additional, Polat, Şefika Burcak, additional, Topaloglu, Oya, additional, Aydın, Cevdet, additional, Cakır, Bekir, additional, Bahadır, Cigdem Tura, additional, Guven, Mehmet, additional, Sözen, Mehmet, additional, Selek, Alev, additional, Canturk, Zeynep, additional, Cetinarslan, Berrin, additional, Aydemir, Mustafa, additional, Taskaldiran, Isilay, additional, Bozkus, Yusuf, additional, Iyidir, Özlem Turhan, additional, Haydardedeoglu, Filiz Eksi, additional, Basmaz, Seda Erem, additional, Unal, Mehmet Cagri, additional, Demir, Tevfik, additional, Oguz, Ayten, additional, Celik, Ozlem, additional, Yilmaz, Merve, additional, Cimsir, Aykut, additional, Kayihan, Serdar, additional, Uc, Ziynet Alphan, additional, Tekin, Sakin, additional, Topaloglu, Ömercan, additional, Saydam, Basak Ozgen, additional, Unsal, Yasemin Aydogan, additional, Ozer, Ozge, additional, Yorulmaz, Goknur, additional, Ugur, Kader, additional, Cakir, Sezin Dogan, additional, Asik, Mehmet, additional, Unubol, Mustafa, additional, Genc, Selin, additional, Andac, Burak, additional, Okur, Mine, additional, Dogan, Ozlem, additional, Karakiliç, Ersen, additional, Kocabas, Gokcen Unal, additional, Kirac, Cem Onur, additional, Cansu, Guven Baris, additional, Uygur, Meliha Melin, additional, Pekkolay, Zafer, additional, Ozturk, Sadettin, additional, Gungunes, Askin, additional, Gurkan, Eren, additional, Keskin, Lezzan, additional, Caglayan, Kenan, additional, Gunay, Yasemin Emur, additional, İmre, Eren, additional, Sener, Selcuk Yusuf, additional, Kalkan, Ahmet Toygar, additional, Gok, Deniz Engin, additional, and Sahin, Mustafa, additional more...
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- 2023
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118. Ustekinumab in Enteropathic Arthritis
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Ulusoy, Bahar Özdemir, primary, Erden, Abdulsamet, additional, Güven, Serdar Can, additional, Armağan, Berkan, additional, Yürekli, Öykü Tayfur, additional, Özin, Yasemin Özderin, additional, Omma, Ahmet, additional, and Küçükşahin, Orhan, additional more...
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- 2023
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119. COVID ‐19 disease frequency, risk factors, and re‐infection rates in patients with autoimmune rheumatic disease receiving rituximab
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Armağan, Berkan, primary, Konak, Hatice Ecem, additional, Özdemir, Bahar, additional, Apaydın, Hakan, additional, Atalar, Ebru, additional, Akyüz Dağlı, Pınar, additional, Güven, Serdar Can, additional, Erden, Abdulsamet, additional, Küçükşahin, Orhan, additional, Omma, Ahmet, additional, and Erten, Şükran, additional more...
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- 2023
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120. The Importance of Eurekan Mountains on Cenozoic Sediment Routing on the Western Barents Shelf
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Flowerdew, Michael J., primary, Fleming, Edward J., additional, Chew, David M., additional, Morton, Andrew C., additional, Frei, Dirk, additional, Benedictus, Aukje, additional, Omma, Jenny, additional, Riley, Teal. R., additional, Badenszki, Eszter, additional, and Whitehouse, Martin J., additional more...
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- 2023
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121. POLİKİSTİK OVER SENDROMU FENOTİPLERİ VE METABOLİK DİSFONKSİYON İLİŞKİSİ
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OSMANLIOĞLU, Şeyma, primary and OMMA, Tülay, additional
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- 2023
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122. Tocilizumab as a first line biologic agent in rheumatoid arthritis patients with inadequate response to disease-modifying anti-rheumatic drugs: real life experience from the TReasure Registry
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Karadag, Omer, primary, Farisogullari, Bayram, additional, Yagiz, Burcu, additional, Erden, Abdulsamet, additional, Ademoglu, Zeliha, additional, Kimyon, Gezmis, additional, Bilge, Nazife Sule, additional, Icacan, Ozan Cemal, additional, Kilic, Levent, additional, Coskun, Belkis Nihan, additional, Ersozlu, Emine Duygu, additional, Kucuksahin, Orhan, additional, Mercan, Ridvan, additional, Koca, Suleyman Serdar, additional, Gonullu, Emel, additional, Cinar, Muhammet, additional, Akar, Servet, additional, Emmungil, Hakan, additional, Kasifoglu, Timucin, additional, Bes, Cemal, additional, Omma, Ahmet, additional, Pehlivan, Yavuz, additional, Kiraz, Sedat, additional, Ertenli, Ihsan, additional, Dalkilic, Ediz, additional, and Kalyoncu, Umut, additional more...
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- 2023
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123. A National Multicenter Study of Leptin (LEP) and Leptin Receptor (LEPR) Deficiency and Systematic Review
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Besci, Özge, primary, Fırat, Sevde Nur, additional, Özen, Samim, additional, Çetinkaya, Semra, additional, Akın, Leyla, additional, Kör, Yılmaz, additional, Pekkolay, Zafer, additional, Özalkak, Şervan, additional, Özsu, Elif, additional, Erdeve, Şenay Savaş, additional, Poyrazoğlu, Şükran, additional, Berberoğlu, Merih, additional, Aydın, Murat, additional, Omma, Tülay, additional, Akıncı, Barış, additional, Demir, Korcan, additional, and Oral, Elif Arioglu, additional more...
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- 2023
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124. The relationship between nutrition, inflammation and colchicine resistance in familial Mediterranean fever
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OMMA, Tülay, primary, ÇOLAK, Seda, additional, CAN SANDIKÇI, Sevinç, additional, ZENGİN, Fatmanur Hümeyra, additional, and OMMA, Ahmet, additional
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- 2022
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125. Provenance of Late Carboniferous to Jurassic sandstones for southern Taimyr, Arctic Russia: A comparison of heavy mineral analysis by optical and QEMSCAN methods
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Zhang, Xiaojing, Pease, Victoria, Omma, Jenny, and Benedictus, Aukje
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- 2015
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126. The Importance of DHEA-S Levels in Cushing’s Syndrome; Is There a Cut-off Value in the Differential Diagnosis?
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Zeliha Hekimsoy, Serdar Sahin, Huseyin Dursun, Hüseyin Soylu, Selvinaz Erol, Mehtap Evran, Kadriye Aydin, Ertorer Melek Eda, Meral Mert, Zafer Pekkolay, Selcukbiricik Ozlem Soyluk, Mine Adaș, Bulent Can, Zeynep Cantürk, Zuleyha Karaca, Seher Tanrikulu, Sema Yarman, Pazir Ayse Esen, Alev Selek, Pinar Kadioglu, Dogansen Sema Ciftci, Berrin Çetinarslan, Gonca Oruk, Ersen Karakilic, Yurekli Banu Sarer, Habib Bilen, and Tülay Omma more...
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Dehydroepiandrosterone-Sulfate ,Pediatrics ,medicine.medical_specialty ,Hydrocortisone ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,adrenal Cushing's syndrome ,Adrenal Androgen ,Biochemistry ,Acth ,Cortisol ,Diagnosis, Differential ,Endocrinology ,Adrenocorticotropic Hormone ,Recurrence ,differential diagnosis ,Medicine ,Humans ,Disease ,DHEA-S cut-off ,Cushing Syndrome ,Secretion ,Retrospective Studies ,S syndrome ,Tumor ,business.industry ,Dehydroepiandrosterone Sulfate ,Cut off value ,Biochemistry (medical) ,ectopic ACTH syndrome ,General Medicine ,Cushing's disease ,Differential diagnosis ,business ,Dissociation ,hormones, hormone substitutes, and hormone antagonists - Abstract
The purpose of this study was to determine possible cut-off levels of basal DHEA-S percentile rank in the differential diagnosis of patients with Cushing’s syndrome (CS) with ACTH levels in the gray zone and normal DHEA-S levels. In this retrospective study including 623 pathologically confirmed CS, the DHEA-S percentile rank was calculated in 389 patients with DHEA-S levels within reference interval. The patients were classified as group 1 (n=265 Cushing’s disease; CD), group 2 (n=104 adrenal CS) and group 3 (n=20 ectopic ACTH syndrome).ROC-curve analyses were used to calculate the optimal cut-off level of DHEA-S percentile rank in the reference interval in the differential diagnosis of CS, and the effectiveness of this cut-off level in the identification of the accurate etiology of CS was assessed in patients who were in gray zone according to their ACTH levels. The DHEA-S percentile rank in the reference interval were significantly lower in group 2 compared to the other two groups (p This study showed that the cut-off value of DHEA-S level less than 20% of the reference interval could be used for differential diagnosis of CD and adrenal CS with high sensitivity and specificity, and it should be taken into the initial evaluation. more...
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- 2022
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127. Antineutrophil cytoplasmic antibody positivity and clinical implications in COVID-19
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Serdar Can Güven, Hakan Apaydın, Bahar Özdemir, Berkan Armağan, İhsan Ateş, Abdulsamet Erden, Orhan Küçükşahin, and Ahmet Omma
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immune system diseases ,Virology ,cardiovascular diseases ,urologic and male genital diseases ,skin and connective tissue diseases ,respiratory tract diseases - Abstract
Aim: To investigate clinical implications of antineutrophil cytoplasmic antibody (ANCA) positivity detected in COVID-19 patients during follow up. Materials & methods: A retrospective survey in a hospital database was carried out to detect COVID-19 patients in which ANCAs had been tested. Clinical, laboratory and imaging data were collected from this hospital database and compared between ANCA-negative and -positive patients. Results: ANCAs were tested in 87 COVID-19 patients. Eight had positivity in at least one ANCA test. COVID-19 symptoms on admission and rate of pulmonary involvement were similar. Acute phase reactant levels were higher in ANCA-positive patients. Rate of mortality was higher in the ANCA-positive group without statistical significance. Conclusion: ANCA positivity detected during COVID-19 in patients without a prior diagnosis of any rheumatic condition may be related with worse outcomes. more...
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- 2022
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128. Evaluation of Coronavirus Disease-2019 Patients with Nailfold Capillaroscopy
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Berkan ARMAĞAN, Bahar ÖZDEMİR, Adalet ALTUNSOY AYPAK, Esragül AKINCI, Özlem KARAKAŞ, Serdar Can GÜVEN, Orhan KÜÇÜKŞAHİN, Ahmet OMMA, and Abdulsamet ERDEN
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General Medicine - Published
- 2022
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129. The clinical significance of antiphospholipid antibodies in COVID-19 infection
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Ebru Atalar, Abdulsamet Erden, Serdar Can Guven, Berkan Armagan, İhsan Ates, Orhan Küçüksahin, and Ahmet Omma
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Infectious Diseases ,immune system diseases ,Virology ,Antibodies, Antiphospholipid ,COVID-19 ,Humans ,Parasitology ,General Medicine ,Antiphospholipid Syndrome ,neoplasms ,Microbiology ,Retrospective Studies - Abstract
Introduction: One of the factors that may aggravate the clinical presentation in COVID-19 is the increased level of antiphospholipid antibodies (aPLs) and thrombotic events that can be seen with the disease. In our retrospective study, we aimed to evaluate the effect of aPLs on the clinical findings in patients with a diagnosis of COVID-19. Methodology: Seventy-three patients diagnosed with COVID-19 and examined for aPLs were included in the study. Patients were divided into two groups according to the test results of aPLs. Clinical and laboratory parameters were compared in both groups to reveal whether there was any difference between the groups. Results: There were 15 patients with a positive aPLs test. Dyspnea, nausea, vomiting, myalgia, and abdominal pain were significantly higher in the aPLs positive group than those with negative aPLs. The duration of hospital stays and the need for oxygen therapy of the patients in the aPLs positive group were significantly higher than the aPLs negative group. However, no difference was found between the two groups in terms of mechanical ventilation need, intensive care admission rate, thrombosis and mortality. In terms of laboratory findings, those with positive aPLs have higher median C-reactive protein (CRP) and ferritin values than those with negative aPLs. Conclusions: In our study group, we could not find a relationship between aPLs positivity and critical complications. According to our hypothesis, it may not be necessary to routinely examine aPLs in patients with a diagnosis of COVID-19 to determine the risk of thromboembolic complications. more...
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- 2022
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130. Status of Anxiety Disorders among Elderly People in a Selected Urban Area in Bangladesh
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Omma Hafsa Any, Sharna Moin, Mahbuba Akter, Khandakar Nadia Afreen, and Manas Kanti Mazumder
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Background: Anxiety disorders are reported in the different age group of people in the urban area. Objective: The purpose of the present study was to determine the level of anxiety disorder among urban elderly people. Methodology: This cross-sectional community based study was carried out from January to December 2016 at Bakolia, Chawkbazar urban area of Chittagong, Bangladesh.The individuals who were aged 60 years and above were interviewed by using convenient sampling. Face to face interview was done with semi structural questionnaire. Results: Out of 300 respondents female respondents were higher in number which was 168(56%) respondents; however, 71.7%, respondents were in 60 to 69 age groups. Majority of respondents did not have any income which was 72(60.0%) subjects. Most of the respondents were suffering from hypertension which was 198(66.0%) respondents. In urban areas 82(27.3%) subjects did not have anxiety disorder, while 133(44.3%) respondents had mild anxiety disorder, 63 (21.0%) respondents had moderate and 22 (7.3%) respondents had severe anxiety disorder. Furthermore, 192 (64.0%) respondents who were concerned about their finance had anxiety disorder. 160 (53.3%) were concerned about their health had anxiety disorder. Conclusion: In conclusion majority urban dwelling elderly people are suffering from anxiety disorders. Journal of National Institute of Neurosciences Bangladesh, July 2021, Vol. 7, No. 2, pp. 137-141 more...
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- 2022
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131. Semaphorin 3A levels in vascular and nonvascular phenotypes in systemic sclerosis
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Mehmet Kayaalp, Abdulsamet Erden, Hakan Apaydin, Serdar Can Güven, Berkan Armağan, Merve Cağlayan Kayaalp, Esma Andac Uzdogan, Şeymanur Ala Enli, Ahmet Omma, and Orhan Kucuksahin
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Biochemistry (medical) ,Clinical Biochemistry - Abstract
Objective Semaphorin 3A (Sema3A) plays a regulatory role in immune responses. The aim of this study was to evaluate Sema3A levels in patients with systemic sclerosis (SSc), especially in major vascular involvements such as digital ulcer (DU), scleroderma renal crisis (SRC), pulmonary arterial hypertension (PAH), and to compare Sema3A level with SSc disease activity. Methods In SSc patients, patients with DU, SRC, or PAH were grouped as major vascular involvements and those without as nonvascular, and Sema3A levels were compared between the groups and with a healthy control group. The Sema3A levels and acute phase reactants in SSc patients, as well as their association with the Valentini disease activity index and modified Rodnan skin score, were evaluated. Results The Sema3A values (mean ± SD) were 57.60 ± 19.81 ng/mL in the control group (n = 31), 44.32 ± 5.87 ng/mL in patients with major vascular involvement SSc (n = 21), and 49.96 ± 14.00 ng/mL in the nonvascular SSc group (n = 35). When all SSc patients were examined as a single group, the mean Sema3A value was significantly lower than controls (P = .016). The SSc with major vascular involvement group had significantly lower Sema3A levels than SSc with nonmajor vascular involvement group (P = .04). No correlation was found between Sema3A, acute phase reactants, and disease activity scores. Also, no relationship was observed between Sema3A levels and diffuse (48.36 ± 11.47 ng/mL) or limited (47.43 ± 12.38 ng/mL) SSc types (P = .775). Conclusion Our study suggests that Sema3A may play a significant role in the pathogenesis of vasculopathy and can be used as a biomarker in SSc patients with vascular complications such as DU and PAH. more...
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- 2023
132. Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study
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Adnan Batman, Dilek Yazıcı, Oğuz Dikbaş, Kemal Ağbaht, Emre Sedar Saygılı, İbrahim Demirci, Nurbanu Bursa, Görkem Ayas, Cüneyd Anıl, Mustafa Cesur, Fatma Nur Korkmaz, Adile Begüm Bahçecioglu, Demet Çorapçıoğlu, Murat Faik Erdoğan, Hayri Bostan, Murat Calapkulu, Sema Hepşen, Bekir Uçan, Erman Çakal, Bağdagül Yüksel Güler, Cem Haymana, Süleyman Hilmi İpekçi, Selami Aydın, Havva Sezer, Seçil Özışık, Oğuzhan Deyneli, Faruk Alagöl, Refik Tanakol, Mustafa Eroğlu, Ümmü Mutlu, Hülya Hacışahinoğulları, Ayşe Kubat Üzüm, Canan Demir, Gönül Koç, Sevde Nur Fırat, Tülay Omma, Nurcan İnce, Şefika Burçak Polat, Oya Topaloğlu, Cevdet Aydın, Bekir Çakır, Çiğdem Tura Bahadır, Mehmet Güven, Mehmet Sözen, Alev Selek, Zeynep Cantürk, Berrin Çetinarslan, Mustafa Aydemir, Işılay Taşkaldıran, Yusuf Bozkuş, Özlem Turhan İyidir, Filiz Ekşi Haydardedeoğlu, Seda Erem Basmaz, Mehmet Çağrı Ünal, Tevfik Demir, Ayten Oğuz, Özlem Çelik, Merve Yilmaz, Aykut Cimsir, Serdar Kayıhan, Ziynet Alphan Uc, Sakin Tekin, Ömercan Topaloğlu, Başak Özgen Saydam, Yasemin Aydoğan Ünsal, Özge Özer, Göknur Yorulmaz, Kader Uğur, Sezin Doğan Çakır, Mehmet Aşık, Mustafa Unubol, Selin Genc, Burak Andac, Mine Okur, Ozlem Dogan, Ersen Karakiliç, Gokcen Unal Kocabas, Cem Onur Kirac, Güven Barış Cansu, Meliha Melin Uygur, Zafer Pekkolay, Sadettin Öztürk, Aşkın Güngüneş, Eren Gürkan, Lezzan Keskin, Kenan Çağlayan, Yasemin Emur Günay, Eren İmre, Selcuk Yusuf Şener, Ahmet Toygar Kalkan, Deniz Engin Gök, and Mustafa Şahin more...
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Endocrinology ,Endocrinology, Diabetes and Metabolism ,Biochemistry (medical) ,Clinical Biochemistry ,Biochemistry - Abstract
Context The aims of the study are to compare characteristics of subacute thyroiditis (SAT) related to different etiologies, and to identify predictors of recurrence of SAT and incident hypothyroidism. Methods This nationwide, multicenter, retrospective cohort study included 53 endocrinology centers in Turkey. The study participants were divided into either COVID-19–related SAT (Cov-SAT), SARS-CoV-2 vaccine–related SAT (Vac-SAT), or control SAT (Cont-SAT) groups. Results Of the 811 patients, 258 (31.8%) were included in the Vac-SAT group, 98 (12.1%) in the Cov-SAT group, and 455 (56.1%) in the Cont-SAT group. No difference was found between the groups with regard to laboratory and imaging findings. SAT etiology was not an independent predictor of recurrence or hypothyroidism. In the entire cohort, steroid therapy requirement and younger age were statistically significant predictors for SAT recurrence. C-reactive protein measured during SAT onset, female sex, absence of antithyroid peroxidase (TPO) positivity, and absence of steroid therapy were statistically significant predictors of incident (early) hypothyroidism, irrespective of SAT etiology. On the other hand, probable predictors of established hypothyroidism differed from that of incident hypothyroidism. Conclusion Since there is no difference in terms of follow-up parameters and outcomes, COVID-19– and SARS-CoV-2 vaccine–related SAT can be treated and followed up like classic SATs. Recurrence was determined by younger age and steroid therapy requirement. Steroid therapy independently predicts incident hypothyroidism that may sometimes be transient in overall SAT and is also associated with a lower risk of established hypothyroidism. more...
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- 2023
133. Tofacitinib experience in patients with enteropathic arthritis
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Pınar Akyüz Dağlı, Abdulsamet Erden, Serdar Can Güven, Berkan Armağan, Öykü Tayfur Yürekli, Yasemin Özderin Özin, Ahmet Omma, and Orhan Küçükşahin
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Oncology ,Immunology ,Immunology and Allergy - Abstract
Background/aim: The JAK-STAT pathway is involved in the pathogenesis of both the inflammatory bowel disease (IBD) and spondyloarthropathy group of diseases. The purpose of this study was to evaluate the effectiveness of tofacitinib, a Janus kinase inhibitor, in the treatment of enteropathic arthritis (EA). Materials & methods: The study included seven patients, four from the authors' follow-up and three from the literature. All cases were recorded for demographic characteristics, comorbidities, IBD and EA symptoms, medical treatments and changes in clinical and laboratory results with treatment. Results & conclusion: Clinical and laboratory remission in terms of IBD and EA was achieved in three patients after tofacitinib treatment. For both spondyloarthritis spectrum diseases and IBD, tofacitinib may be an appropriate choice, as its efficacy has been shown in both conditions. more...
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- 2023
134. A New Predictor for Insulin Resistance in Polycystic Ovary Syndrome: InsuTAG
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Tulay Omma, Aksanur Gokce, Mustafa Celik, Irfan Karahan, Cavit Culha, and Nese Ersoz Gulcelik
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Obstetrics and Gynecology - Abstract
Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among women of reproductive age. PCOS leads to metabolic dysfunction such as dyslipidemia, obesity, and glucose intolerance based on hyperandrogenemia, hyperinsulinemia, and dysregulated adipokine secretion. Objective: The aim of this study was to investigate whether a new marker, InsuTAG (fasting insulin×fasting triglycerides) could predict insulin resistance (IR) in patients of PCOS. Methods: In this study, retrospective data of 300 female patients diagnosed with PCOS were analyzed. The relationship between InsuTAG and HOMA-IR, TyG, and TG/HDL-C scores related to insulin resistance was evaluated. In addition, the distribution of the cases according to the cut-off values was determined. Results: Log-transformed forms of InsuTAG and HOMA-IR, TyG and TG/HDL-C results were positively correlated, respectively. (r=0.85, p Conclusions: This study is the first to compare the InsuTAG, another predictor of insulin resistance, with other IR markers in women with PCOS. InsuTAG is a novel biomarker based on plasma sampling of insulin and triglyceride, with minimally invasive, inexpensive and orientally accessible features. more...
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- 2023
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135. A National Multicenter Study of Leptin (LEP) and Leptin Receptor (LEPR) Deficiency and Systematic Review
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Özge Besci, Sevde Nur Fırat, Samim Özen, Semra Çetinkaya, Leyla Akın, Yılmaz Kör, Zafer Pekkolay, Şervan Özalkak, Elif Özsu, Şenay Savaş Erdeve, Şükran Poyrazoğlu, Merih Berberoğlu, Murat Aydın, Tülay Omma, Barış Akıncı, Korcan Demir, and Elif Arioglu Oral more...
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Endocrinology ,Endocrinology, Diabetes and Metabolism ,Biochemistry (medical) ,Clinical Biochemistry ,Biochemistry - Abstract
Context Homozygous leptin (LEP) and leptin receptor (LEPR) variants lead to childhood-onset obesity. Objective To present new cases with LEP and LEPR deficiency, report the long-term follow-up of previously described patients, and to define, based on all reported cases in literature, genotype-phenotype relationships. Methods Our cohort included 18 patients (LEP = 11, LEPR = 7), eight of whom had been previously reported. A systematic literature review was conducted in July 2022. 42/47 studies on LEP/LEPR were selected. Results Of 10 new cases, two novel pathogenic variants were identified in LEP (c.16delC) and LEPR (c.40+5G>C). Eleven patients with LEP deficiency received metreleptin, four of whom had been treated for over 20 years. One patient developed loss of efficacy associated with neutralizing antibody development. Of 152 patients, including 134 cases from the literature review in addition to our cases, frameshift variants were the most common (48%) in LEP and missense variants (35%) in LEPR. Patients with LEP deficiency were diagnosed at a younger age (3 (9) vs. 7 (13) years, p = 0.02), and had a higher median BMI SD score (3.1 (2) vs. 2.8 (1) kg/m2, p = 0.02), which was more closely associated with frameshift variants (p = 0.02). Patients with LEP deficiency were more likely to have hyperinsulinemia (p = 0.02). Conclusion Frameshift variants were more common in patients with LEP deficiency whereas missense variants were more common in LEPR deficiency. Patients with LEP deficiency were identified at younger ages, had higher BMI SD scores, and had higher rates of hyperinsulinemia than patients with LEPR deficiency. Eleven patients benefited from long-term metreleptin, with one losing efficacy due to neutralizing antibodies. more...
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- 2023
136. Performance of the systemic lupus erythematosus risk probability index in a cohort of undifferentiated connective tissue disease
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Abdulsamet Erden, Hakan Apaydın, Antonis Fanouriakis, Serdar Can Güven, Berkan Armagan, Pınar Akyüz Dağlı, Hatice Ecem Konak, Bünyamin Polat, Ebru Atalar, Serdar Esmer, Özlem Karakaş, Bahar Özdemir, Mehmet Akif Eksin, Ahmet Omma, Orhan Kücüksahin, George K Bertsias, and Dimitrios T Boumpas more...
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Cohort Studies ,Rheumatology ,Humans ,Lupus Erythematosus, Systemic ,Pharmacology (medical) ,Undifferentiated Connective Tissue Diseases ,Connective Tissue Diseases ,Probability - Abstract
Objectives We sought to evaluate the performance of the SLE Risk Probability Index (SLERPI) for identification of SLE in a large cohort of patients with UCTD. Methods The SLERPI was applied in a cohort of patients who met classification criteria for UCTD and did not fulfil any classification criteria for other defined CTD including SLE. Patients with a SLERPI score of >7 were ‘diagnosed’ as SLE. Patients diagnosed with SLE and those not were compared in terms of disease characteristics and index parameters. Results A total of 422 patients with UCTD were included in the study. Median (interquartile range) SLERPI was 4.25 (2.5) points, while 39 (9.2%) patients had a SLERPI score >7 and were diagnosed as SLE. Patients with younger age (P = 0.026) and presence of malar rash (P 500 mg/24 h (P = 0.001), thrombocytopenia (P = 0.009) or autoimmune haemolytic anaemia (P Conclusion SLERPI enabled a significant proportion of patients to be identified as SLE in our UCTD cohort. This new probability index may be useful for early identification of SLE among patients with signs of CTD without fulfilling any definite criteria set. more...
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- 2022
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137. COVID-19 outcomes in patients with antiphospholipid syndrome: a retrospective cohort study
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A, Erden, O, Karakas, B, Armagan, S C, Guven, B, Ozdemir, E, Atalar, H, Apaydin, E, Usul, I, Ates, A, Omma, and O, Kucuksahin
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Economics and Econometrics ,SARS-CoV-2 ,Antibodies, Antiphospholipid ,Materials Chemistry ,Media Technology ,Anticoagulants ,COVID-19 ,Humans ,Forestry ,Heparin, Low-Molecular-Weight ,Antiphospholipid Syndrome ,Retrospective Studies - Abstract
Aim of this study is to investigate COVID-19 outcomes in patients with antiphospholipid syndrome (APS).A retrospective cohort was formed from APS patients. Patients were screened for a record of positive SARS-CoV 2 PCR. In PCR‑positive patients, clinical data and information regarding COVID-19 outcomes were collected from medical records.A positive PCR test was detected in 9/53 APS patients, while 66.7 %, 33.3 % and 11.1 % of APS patients with COVID-19 were under hydroxychloroquine, LMWH or warfarin, and acetylsalicylic acid, respectively. There were 3/9 patients found to be hospitalized and one died. No new thrombotic event was reported in any of the patients during COVID-19 infection.Baseline use of hydroxychloroquine, antiaggregants and anticoagulants may be associated with an absence of new thrombotic event (Tab. 2, Ref. 33). more...
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- 2022
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138. An overview of the hematological picture with antithyroid therapy in Graves' disease
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Aksanur Gokce, Tulay Omma, Mustafa Çelikc, and Işılay Taşkaldıran
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General Medicine - Abstract
Aim: Graves' disease is an autoimmune thyroid disease that is the most common cause of hyperthyroidism. Peripheral blood cell parameters such as neutrophils, lymphocytes, and platelets play a role in inflammation control. Several studies have proven that neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio are indicators of chronic subclinical inflammation in various diseases. In our study, we aimed to review the peripheral blood picture by evaluating these parameters before and after antithyroid treatment in patients with Graves' disease. Patients and methods: A total of 120 patients (93 female, 27 male) between the ages of 18-65 were included. Demographic data, hemogram and biochemical data of the patients were recorded retrospectively at the time of diagnosis and after euthyroidism was achieved with medical treatment. Results: During the treatment, there was an increase in hemoglobin, lymphocytes, neutrophils and red cell distribution width, while a decrease in monocytes was observed. There was no significant difference between white blood cell, platelet and mean platelet volume. In addition, while there was no statistically significant difference between neutrophil-lymphocyte ratio (p = 0.8) and thrombocyt-lymphocyte ratio (p = 0.078) after euthyroid state, a statistically significant difference was found in favor of a decrease in monocyte-lymphocyte ratio (p = 0.006). Conclusion: Changes in hematopoiesis are relatively common in patients with newly diagnosed Graves' disease, and initiation of antithyroid therapy leads to improvement in these parameters. Although neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio are accepted as new, non-invasive markers in clinical evaluation, in our study only a significant decrease in monocyte-lymphocyte ratio levels was observed after euthyroidism was achieved with antithyroid treatment. more...
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- 2022
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139. An evaluation of the results of convalescent plasma therapy applied to pregnant womendiagnosed as COVID-19- positive in a pandemic center: A prospective cohort study
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SEYİT AHMET EROL, ATAKAN TANAÇAN, HAKAN APAYDIN, ŞULE GÖNCÜ AYHAN, DENİZ OLUKLU, DERYA UYAN HENDEM, SERPİL ÜNLÜ, ABDULSAMET ERDEN, ÖZLEM MORALOĞLU TEKİN, AHMET OMMA, İHSAN ATEŞ, ORHAN KÜÇÜKŞAHİN, and DİLEK ŞAHİN more...
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General Medicine - Published
- 2022
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140. Metabolic syndrome is associated with increased cardiovascular risk and disease damage in patients with Takayasu arteritis
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Burçin Sağlam, Sema Kaymaz‐Tahra, Gökçe Kenar, Sinem Kocaer, Ahmet Omma, Abdulsamet Erden, Mete Kara, Ayten Yazıcı, Ayşe Cefle, Önay Gerçik, Servet Akar, Kenan Aksu, Gökhan Keser, Handan Yarkan Tuğsal, Fatoş Önen, Sevil Kamalı, Fatma Alibaz‐Öner, Haner Direskeneli, Nilüfer Alpay‐Kanıtez, and Sağlam B., Kaymaz-Tahra S., Kenar G., Kocaer S., Omma A., Erden A., Kara M., Yazıcı A., Cefle A., Gerçik Ö., et al. more...
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Adult ,Male ,RHEUMATOLOGY ,Klinik Tıp ,MULTICENTER ,Middle Aged ,CLINICAL MEDICINE ,Clinical Medicine (MED) ,metabolic syndrome ,vasculitis ,Cross-Sectional Studies ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Risk Factors ,cardiovascular disease ,Humans ,Female ,Klinik Tıp (MED) ,ROMATOLOJİ ,Takayasu arteritis - Abstract
Objective: Metabolic syndrome (MetS) is one of the preventable risk factors for cardiovascular disease (CVD). The aim of this study was to investigate the effect of MetS on CVD and cumulative organ damage in a multi-center, large cohort of patients with Takayasu arteritis (TAK). Methods: This is a cross-sectional study involving 192 consecutive TAK patients from seven tertiary rheumatology centers in Turkey. Clinical data of TAK patients fulfilling the 1990 American College of Rheumatology classification criteria were collected from medical records. They were evaluated for risk factors of CVD, disease activity, damage, and MetS at their last visits. Results: A total of 192 consecutive TAK patients were included in this study. One hundred and fifty-eight (82%) were female, the mean age was 43.3 +/- 13 years, and mean disease duration was 13.5 +/- 9.3 years. MetS was detected in 50 (26%) of the patients and CVD was detected in 28 (14.6%). The presence of MetS was detected as an independent risk factor for CVD (P < 0.001). In addition, the mean vasculitis damage index of the group with MetS was significantly higher than in the other patients (4.5 +/- 3.3 vs 3.2 +/- 2.2, respectively, P = 0.004). Conclusion: The presence of MetS in TAK is associated with increased CVD and disease damage. Awareness and management of MetS can improve disease prognosis in patients with TAK. more...
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- 2022
141. Determination of serum vascular endothelial growth factor (VEGF) and VEGF receptor levels with VEGF gene polymorphisms in patients with Behçet’s uveitis
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Erdim Sertoglu, çiğdem yücel, Ahmet Omma, Yildiz Hayran, Seda Colak, Sevinc CAN SANDIKÇI, Ali Durukan, and Taner Ozgurtas
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Vascular Endothelial Growth Factor A ,Polymorphism, Genetic ,Vascular Endothelial Growth Factor Receptor-1 ,Behcet Syndrome ,Case-Control Studies ,Reviews and References (medical) ,Internal Medicine ,Humans ,Medicine (miscellaneous) ,Pharmacology (medical) ,Vascular Endothelial Growth Factor Receptor-3 ,General Biochemistry, Genetics and Molecular Biology ,Genetics (clinical) - Abstract
Behçet's disease (BD) is a chronic inflammatory vasculitis affecting multiple organs. Uveitis is frequently seen in patients with BD, especially in Turkish population.To investigate vascular endothelial growth factor (VEGF) gene polymorphisms along with the levels of VEGF and VEGF receptors in patients with Behçet's uveitis (BU).Fifty-five BD-associated uveitis patients and 30 ageand sex-matched controls were included in this case-control study. The genotypes of the single nucleotide poymorphisms (SNPs): rs2010963 (+405G), rs3025039 (+936T) and rs699947 (-2598A) of the VEGF-A gene were determined using real-time polymerase chain reaction (RT-PCR) and serum levels of VEGF and VEGF receptors were measured using enzyme-linked immunosorbent assay (ELISA).No associations of the VEGF gene polymorphisms were observed in BD uveitis patients, but arthritis was present in 53.3% of patients not possessing CT genotype in C3025039→T polymorphism (p = 0.024). Although there were no statistically significant differences in serum VEGF-A, VEGF-C and soluble vascular endothelial growth factor receptor-3 (sVEGFR-3) levels (p0.05), serum vascular endothelial growth factor receptor-1 (VEGFR-1) and sVEGFR-3 levels were significantly higher in the BD group (p0.001 and p = 0.001, respectively). In addition, VEGF-C/soluble vascular endothelial growth factor receptor-2 (sVEGFR-2) ratio was significantly higher (p0.001), while VEGF-A/VEGFR-1 and VEGF-C/sVEGFR-3 ratios were significantly lower (p0.001 and p = 0.033, respectively) in BD patients compared to controls. Also, VEGF-C/sVEGFR-3 (p = 0.024, r = 0.37) and VEGF-C/sVEGFR-2 (p = 0.020, r = 0.38) ratios were positively correlated with disease duration.The significant changes in sVEGFR-3 levels and VEGF-C/sVEGFR-3 ratio has shown that lymphangiogenesis processes might take place in the pathogenesis of BD uveitis, and these parameters can be important indicators of evaluation of BD patients with uveitis together with disease duration. more...
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- 2021
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142. CO-CREATE Comprehensive Policy-Brief to the EU Commission. Roadmap to Decolonial Arctic Research
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Herrmann, Thora Martina, Brunner Alfani, Francesca, Chahine, Anne, Doering, Nina, Dudeck, Stephan, Elster, Josef, Fjellheim, Eva, Henriksen, Jan Erik, Hermansen, Nina, Holmberg, Aslak, Kramvig, Britt, Nystø Keskitalo, Anja Márjá, Omma, Elle Merete, Saxinger, Gertrude, Scheepstra, Annette, and van der Schot, Jorrit more...
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decolonial methodologies ,role of funding organisations ,Indigenous research politics ,Indigenous rights holders as research actors ,ÖFOS 2012 -- SOCIAL SCIENCES (5) -- Other Social Sciences (509) -- Other Social Sciences (5090) -- Action research (509001) ,co-creative and collaborative methods ,Aktionsforschung ,Arctic research ,ÖFOS 2012 -- SOZIALWISSENSCHAFTEN (5) -- Andere Sozialwissenschaften (509) -- Andere Sozialwissenschaften (5090) -- Aktionsforschung (509001) ,Indigenous rights ,Action research - Abstract
The "Comprehensive Policy Brief to the EU Commission - Roadmap to Decolonial Arctic Research" is an evidence-based tool for achieving decolonial innovation in methodology and funding mechanisms in the Arctic research landscape, including the natural and social sciences and the humanities. In four concise chapters, the group of experts, consisting of Indigenous and non-Indigenous researchers and Indigenous rights holders, 1) guide the readership through the legal and political dimensions as well as that of research innovation and paradigmatic shifts in Arctic research; 2) it offers concrete methodological considerations in carrying out projects; 3) it elaborates on the participation of Indigenous rights holders in the EU research funding structures from a practice perspective. 4) it outlines the benefits of Indigenous-led Arctic research and of funding co-creative projects. This Roadmap can support the mainstreaming of co-creative and collaborative principles and equal partnership by Indigenous and non-Indigenous actors in 1) large-scale research projects, 2) calls for projects, 3) proposal design and project evaluation, and 4) in the implementation of the European Polar Research Program. At the international level, the rights of Indigenous Peoples have been receiving increasing legal recognition. Similarly, EU calls-for-proposals ask nowadays increasingly for a ‘co-design approach’ in research (e.g., in the past Horizon 2020, and the current Horizon Europe funding schemes). Arctic researchers are increasingly adopting decolonial research approaches. Yet implementing decolonial research practices as new standards and taking initiative that supports Indigenous sovereignty in the Arctic is often still lacking. Therefore, theoretical and methodological expertise about co-creation of knowledge, as offered in this Roadmap, can help to foster capacity among researchers in all disciplines (natural and social sciences, the humanities) and among the relevant funding bodies such as the EU Commission and the large variety of international and national funding organisations. more...
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- 2023
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143. Derivation and validation of adult Still Activity Score (SAS)
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Mutlu Hayran, Kenan Aksu, Hakan Emmungil, Emre Bilgin, Cemal Bes, Abdulsamet Erden, Ediz Dalkilic, Servet Akar, Ahmet Omma, Orhan Küçükşahin, Selime Ermurat, Umut Kalyoncu, Nilüfer Alpay Kanıtez, Timuçin Kaşifoğlu, Fatih Yildiz, and Muhammet Cinar more...
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History ,medicine.medical_specialty ,Ferritin ,Scoring system ,Adult-onset Still?s disease ,Polymers and Plastics ,business.industry ,Ethics committee ,Arthralgia ,Industrial and Manufacturing Engineering ,Helsinki declaration ,Disease Course ,Rheumatology ,Informed consent ,Internal medicine ,Clinical-Manifestations ,Linear regression ,Disease activity score ,medicine ,Test performance ,Derivation ,Ordered logit ,Business and International Management ,business ,Multicenter - Abstract
Background/Aim: Adult-onset Still’s disease (AOSD) is a multi-systemic, autoinflammatory disorder. Several activity scores have been proposed but none of them have been adopted universally. Our aim was to create a clinician-friendly activity scoring system by using simple clinical and laboratory parameters. Methods: AODS patients according to Yamaguchi criteria were included in this cross-sectional, multi-center study. Derivation and validation cohorts were constituted. Demographic, clinical and laboratory evaluation at study visit; patients’, and physicians’ global assessments of disease activity (both VAS/ Likert scale) were recorded. To develop the score; ordinal logistic regression model was used to determine independent predictors of patient’ global assessments of disease activity. Clinically and statistically significant variables were weighted according to regression coefficients. Then, performance of the score was tested on the validation cohort. Results: Total of 197 consecutive AOSD patient (125 in derivation, 72 in validation cohorts) were included. Final Still Activity Score was fever (2 points), arthralgia (2 points, plus 1 point if arthritis was present in ≥2 joints), neutrophilia≥65% (1 point) and ferritin≥350 ng/mL (1 point) (maximum of 7 points). The SAS yielded an AUC value of 0.98(0.96-1.00) in the derivation cohort and 0.91(95%CI:0.85-0.98) in the validation cohort to discriminate high AOSD activity from moderate-inactive AOSD. Correlation of SAS with PtGA was 83% for the derivation cohort and 76% for the validation cohort. Conclusions: SAS has shown a good test performance to distinguish active AOSD patients from the others. SAS may be a useful method for evaluating disease activity of AOSD patients in daily practice. Funding: None to declare. Declaration of Interest: None to declare. Ethical Approval: The present study was conducted in compliance with the Helsinki Declaration and was approved by the Local Ethics Committee of Hacettepe University (GO- 20/824). A written informed consent form was completed by all participants. more...
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- 2023
144. Evaluation of adult immunoglobulin A vasculitis with oxidative stress and inflammation biomarkers
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Balik, Zeynep, primary, Balik, Ahmet, additional, Omma, Ahmet, additional, Yucel, Cigdem, additional, Kizilgun, Murat, additional, Oguz, Esra, additional, Neselioglu, Salim, additional, and Erel, Ozcan, additional more...
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- 2023
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145. Percentage of immature granulocytes in subacute thyroiditis follow-up and differential diagnosis with Graves’ disease
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Fırat, Sevde Nur, primary, Omma, Tülay, additional, Gökbulut, Püren, additional, Kuşkonmaz, Şerife Mehlika, additional, and Çulha, Cavit, additional
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- 2023
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146. Effects of breast milk on Behçet's disease clinical features
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KONAK, HATİCE ECEM, primary, ERDEN, ABDULSAMET, additional, ARMAĞAN, BERKAN, additional, GÜVEN, SERDAR CAN, additional, APAYDIN, HAKAN, additional, DAĞLI, PINAR AKYÜZ, additional, UZUN, YAĞNUR, additional, KAYGISIZ, MERVE, additional, KÜÇÜKŞAHİN, ORHAN, additional, and OMMA, AHMET, additional more...
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- 2023
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147. Effects of sulfasalazine in axial spondyloarthritis on COVID-19 outcomes: real-life data from a single center
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Berkan Armağan, Ebru Atalar, Serdar Can Güven, Bahar Özdemir, Hatice Ecem Konak, Pınar Akyüz Dağlı, Abdulsamet Erden, Kevser Gök, Yüksel Maraş, İsmail Doğan, Orhan Küçükşahin, Şükran Erten, and Ahmet Omma more...
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Pharmacology ,Immunology ,Immunology and Allergy ,General Medicine ,Toxicology - Abstract
Compared to biological agents, little is known about the impact of sulfasalazine therapy on COVID-19 outcomes in patients with Axial Spondyloarthritis (AxSpA). Therefore, we aimed to evaluate the COVID-19 severity in AxSpAs receiving sulfasalazine and biologic-agent.A total of 219 SARS-CoV-2 positive AxSpA patients were retrospectively analyzed. COVID-19 pneumonia, hospitalization rate, and length of stay were used to determine COVID-19 severity. AxSpA patients were mainly grouped and compared as sulfasalazine and non-sulfasalazine. Afterward, we excluded no-treatment patients to reveal the drug's effects more clearly and regrouped AxSpA patients as sulfasalazine-monotherapy (34.3%), biologic-monotherapy (33.7%), and sulfasalazine + biologic (7.3%).Fifty-nine percent of the patients were male and the mean age was 45.0 years. Peripheral arthritis was 35% and uveitis 15%. In total, 41.5% of them have received sulfasalazine and 41.0% biologic agents, and the remaining patients with no AxSpA-specific treatment. In the first comparison, the sulfasalazine group had a higher age, more frequent COVID-19 pneumonia, hospitalization, and longer hospitalization than a non-sulfasalazine group. In the pairwise comparison of 3 treatment groups, the demographic and clinical features, the hospitalization rate and the length of hospital stay were similar but the sulfasalazine-monotherapy group had a higher frequency of COVID-19 pneumonia than the biologic-monotherapy group (23% vs. 7%,Our results imply sulfasalazine may be related to more severe COVID-19 in AxSpA patients. These patients should be followed more carefully in the presence of COVID-19, regardless of reasons such as age, comorbidity, and extra-axial disease, and consideration of discontinuing sulfasalazine maybe even thought. more...
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- 2022
148. Effects of sulfasalazine in axial spondyloarthritis on COVID-19 outcomes: real-life data from a single center
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Armağan, Berkan, primary, Atalar, Ebru, additional, Güven, Serdar Can, additional, Özdemir, Bahar, additional, Konak, Hatice Ecem, additional, Akyüz Dağlı, Pınar, additional, Erden, Abdulsamet, additional, Gök, Kevser, additional, Maraş, Yüksel, additional, Doğan, İsmail, additional, Küçükşahin, Orhan, additional, Erten, Şükran, additional, and Omma, Ahmet, additional more...
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- 2022
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149. A Multi-proxy Provenance Study of Late Carboniferous to Middle Jurassic Sandstones in the Eastern Sverdrup Basin and Its Bearing on Arctic Palaeogeographic Reconstructions
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Pointon, Michael A., primary, Smyth, Helen, additional, Omma, Jenny E., additional, Morton, Andrew C., additional, Schneider, Simon, additional, Hülse, Peter, additional, Rippington, Stephen J., additional, Lopez-Mir, Berta, additional, Crowley, Quentin G., additional, Millar, Ian, additional, Whitehouse, Martin J., additional, Frei, Dirk, additional, Scott, Robert A., additional, and Flowerdew, Michael J., additional more...
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- 2022
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150. Restless leg syndrome and sleep quality in granulomatosis with polyangiitis
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Güven, Serdar Can, primary, Akyüz Dağlı, Pınar, additional, Karacaoğlu, Selin, additional, Armağan, Berkan, additional, Erden, Abdulsamet, additional, Küçükşahin, Orhan, additional, and Omma, Ahmet, additional more...
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- 2022
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