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1,080 results on '"Otsuki, Makoto"'

122. Troglitazone stimulates pancreatic growth in congenitally CCK-A receptor-deficient OLETF rats

Author

JIA, DONG MEI, FUKUMITSU, KEN-ICHIRO, TABARU, AKINARI, AKIYAMA, TOSHIHARU, and OTSUKI, MAKOTO

Subjects
Pancreas -- Physiological aspects, Glucose metabolism -- Research, Troglitazone -- Research, Biological sciences
Abstract

Troglitazone stimulates pancreatic growth in congenitally CCK-A receptor-deficient OLETF rats. Am J Physiol Regulatory Integrative Comp Physiol 280: R1332-R1340, 2001.--We examined the effect of troglitazone treatment on pancreatic growth in the CCK-A receptor-deficient Otsuka Long-Evans Tokushima fatty (OLETF) rat, an animal model for type 2 diabetes mellitus. A troglitazone-rich diet (0.2%) was given from 12 to 28 wk of age or from 12 or 28 wk of age to 72 wk of age. Fasting serum glucose concentrations in control OLETF rats increased progressively with age, which was almost completely prevented by troglitazone treatment. Insulin levels in serum and pancreatic content in the control rat markedly increased at 28 wk of age but significantly decreased at 72 wk of age compared with those at 12 wk of age, whereas those in troglitazone-treated rats were nearly the same at all ages and were similar to those in control rats at 12 wk of age. Pancreatic wet weight in control rats decreased with age irrespective of whether they were hyperinsulinemic (28 wk old) or hypoinsulinemic (72 wk old). Troglitazone treatment significantly increased pancreatic wet weight and protein, DNA, and enzyme contents compared with those in the control rats. Moreover, troglitazone treatment completely prevented or reversed histological alterations such as fibrosis, fatty replacement, and inflammatory cell infiltration. Our results indicate that troglitazone stimulates pancreatic growth in the congenitally CCK-A receptor-deficient OLETF rat not only by reducing insulin resistance and potentiating insulin action but also by suppressing inflammatory changes in the pancreas. insulin; glucose metabolism; peroxisome proliferator-activated receptor-[Gamma]; leptin; cholecystokinin-A; Otsuka Long-Evans Tokushima fatty

Published
2001

134. Proceedings of the 25th annual meeting From October 13–15, 1983—Yamaguchi, Japan

Author

Takasu, Sachio, Takizawa, Thouichiro, Koike, Morio, Tatsuta, Masaharu, Okuda, Shigeru, Okuda, Junichi, Ida, Kazunori, Yamada, Naoyuki, Furuchi, Sohtaroh, Kurokawa, Kimie, Adachi, Hitomi, Sakaki, Nobuhiro, Tada, Masahiro, Yachi, Akira, Namatame, Kimio, Watanabe, Hiromu, Ohara, Shuichi, Asaki, Shigeru, Yoshino, Junji, Nakazawa, Saburo, Hasegawa, Toshihiro, Suzuki, Shigeru, Nakahara, Akira, Fukutomi, Hisayuki, Yoshimura, Katsunori, Saito, Toshihiko, Harada, Kazumichi, Hayashi, Hideki, Sasako, Mitsuru, Iwasaki, Masaru, Kato, Osamu, Hattori, Kazuhiko, Ariyama, Shigemi, Ohshita, Yoshito, Mimura, Seishiro, Ichii, Makoto, Esaki, Masatoshi, Hiratsuka, Hideo, Nishisaka, Tsuyoshi, Yonekawa, Motoki, Ido, Kenichi, Kimura, Ken, Ito, Yoshiaki, Kasugai, Tatsuzo, Maruyama, Masahiro, Kouzu, Teruo, Hirashima, Toshio, Oguro, Yanao, Ozaki, Masayuki, Imaoka, Wataru, Nishioka, Toshio, Sekiguchi, Toshikazu, Funakoshi, Akihiro, Ibayashi, Hiroshi, Naruse, S., Magee, D. F., Otsuki, Makoto, Ohki, Atsushi, Namba, Mitsuyoshi, Matsuyama, Tatsuo, Kishimoto, Shinya, Imamura, Mikio, Sato, Toshio, Nakaya, S., Saitoh, Y., Kanno, Tomio, Marino, Tetsuya, Okada, Toshikuni, Fujimori, Takahiro, Nagasako, Kou, Ohida, Masahito, Saigenji, Katsunori, Hayakawa, Kazuo, Fukuchi, Sotaro, Asakh, Shigeru, Shibuya, Daisuke, Yambe, Toru, Shibuk, Satoru, Okata, Toshiki, Yoshida, Koichi, Shoji, Tadayoshi, Itch, Shoichiro, Mochizuki, Fukuharu, Hamada, Tsutomu, Yarita, Tadashi, Baba, Yasumasa, Takekoshi, Takeo, Misono, Toshiaki, Nakano, H., Sasaki, K., Misumi, Atsunobu, Akagi, Masanobu, Yamaguchi, Hajime, Yoshida, Shigeaki, Kozawa, Hiroshi, Kawaguchi, Shinpei, Iishi, Hiroyasu, Tatsuta, Masaharu, Takechi, Keishi, Ida, Kazunori, Nomura, Hidehiro, Nishi, Mitsumasa, Yamaguchi, Akihiro, Hachisuka, Kitao, Sakamoto, Kazuhiro, Mori, Katsutaka, Sekoguchi, Tsutomu, Mizumoto, Ryuji, Higashino, Yoshinobu, Nagakawa, Takukazu, Matsuno, Seiki, Sato, Toshio, Imaizumi, Toshihide, Hanyu, Fujio, Sada, Masayuki, Nakayama, Toshimichi, Tajiri, Hisao, Yoshimori, Masayoshi, Katagiri, Kenji, Hayashi, Katsuji, Hamasaki, Keisuke, Mimura, Hisashi, Miyata, Susumu, Shibue, Tadashi, Shimaguchi, Seikoh, Ariyama, Joe, Harima, Kazuo, Asagami, Fumio, Ichikawa, Masafumi, and Naito, Yasuo

Published
1984
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139. Animal Models of Chronic Pancreatitis

Author

Otsuki, Makoto, Yamamoto, Mitsuyoshi, and Yamaguchi, Taizo

Subjects
Article Subject
Abstract

Animal models for CP in rats can be classified into 2 groups: one is noninvasive or nonsurgical models and the other is invasive or surgical models. Pancreatic injury induced by repetitive injections of supramaximal stimulatory dose of caerulein (Cn) or by intraductal infusion of sodium taurocholate (NaTc) recovered within 14 days, whereas that caused by repetitive injection of arginine or by intraductal infusion of oleic acid was persistent. However, the destroyed acinar tissues were replaced by fatty tissues without fibrosis. Transient stasis of pancreatic fluid flow by 0.01% agarose and minimum injury of the pancreatic duct by 0.1% NaTc solution induced progressive pancreatic injury although one alone is insufficient to cause persistent pancreatic injury. However, the damaged tissue was replaced by fatty tissue without fibrosis. Continuous pancreatic ductal hypertension (PDH) caused diffuse interlobular and intralobular fibrosis closely resembling human CP.

Published
2010
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140. [Alpha]-Glcosidase Inhibitor Prevents the Development of IGT to NIDDM

Author

KANNDA, KIKUO, AKIYAMA, TOSHIHARU, KUME, KEIICHIROU, DONGMEI, JIA, YAMAMOTO, MITUYOSI, and OTSUKI, MAKOTO

Subjects
Diabetes -- Research, Health
Abstract

[Background] Approximately 1 to 10% of impaired glucose tolerance (IGT) develops to diabetes each year. In this study, we examined whether the long term treatment with [Alpha]-glucosidase inhibitor ([Alpha]GI), acarbose [...]

Published
1999

146. Epidemiological Study of Pancreatic Diabetes in Japan in 2005

Author

Ito, Tetsuhide, primary, Otsuki, Makoto, additional, Igarashi, Hisato, additional, Kihara, Yasuyuki, additional, Kawabe, Ken, additional, Nakamura, Taichi, additional, Fujimori, Nao, additional, Oono, Takamasa, additional, Takayanagi, Ryoichi, additional, and Shimosegawa, Tooru, additional

Published
2010
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150. Differential Diagnosis Between Autoimmune Pancreatitis and Pancreatic Cancer

Author

Kawa, Shigeyuki, primary, Fujinaga, Yasunari, additional, Irisawa, Atsushi, additional, Notohara, Kenji, additional, Hatori, Takashi, additional, Inui, Kazuro, additional, Funakoshi, Akihiro, additional, Suda, Koichi, additional, Takase, Masaru, additional, Akashi, Ryuukichi, additional, Arakura, Norikazu, additional, Kamisawa, Terumi, additional, Koizumi, Masaru, additional, Hirota, Masahiko, additional, Okazaki, Kazuichi, additional, and Otsuki, Makoto, additional

Published
2009
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