2,414 results on '"P. Bennet"'
Search Results
102. Advances in neonatal cell therapies: Proceedings of the First Neonatal Cell Therapies Symposium (2022)
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Malhotra, Atul, Thebaud, Bernard, Paton, Madison C. B., Fleiss, Bobbi, Papagianis, Paris, Baker, Elizabeth, Bennet, Laura, Yawno, Tamara, Elwood, Ngaire, Campbell, Belinda, Chand, Kirat, Zhou, Lindsay, Penny, Tayla, Nguyen, Timothy, Pepe, Salvatore, Gunn, Alistair J., and McDonald, Courtney A.
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- 2023
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103. A novel DPH5-related diphthamide-deficiency syndrome causing embryonic lethality or profound neurodevelopmental disorder
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Shankar, Suma P, Grimsrud, Kristin, Lanoue, Louise, Egense, Alena, Willis, Brandon, Hörberg, Johanna, AlAbdi, Mayer, Klaus, Ütkür, Koray, Monaghan, Kristin G, Krier, Joel, Stoler, Joan, Alnemer, Maha, Shankar, Prabhu R, Schaffrath, Raffael, Alkuraya, Fowzan S, Brinkmann, Ulrich, Eriksson, Leif A, Lloyd, Kent, Rauen, Katherine A, Network, Undiagnosed Diseases, Acosta, Maria T, Adam, Margaret, Adams, David R, Alvey, Justin, Amendola, Laura, Andrews, Ashley, Ashley, Euan A, Azamian, Mahshid S, Bacino, Carlos A, Bademci, Guney, Balasubramanyam, Ashok, Baldridge, Dustin, Bale, Jim, Bamshad, Michael, Barbouth, Deborah, Bayrak-Toydemir, Pinar, Beck, Anita, Beggs, Alan H, Behrens, Edward, Bejerano, Gill, Bennet, Jimmy, Berg-Rood, Beverly, Bernstein, Jonathan A, Berry, Gerard T, Bican, Anna, Bivona, Stephanie, Blue, Elizabeth, Bohnsack, John, Bonner, Devon, Botto, Lorenzo, Boyd, Brenna, Briere, Lauren C, Brokamp, Elly, Brown, Gabrielle, Burke, Elizabeth A, Burrage, Lindsay C, Butte, Manish J, Byers, Peter, Byrd, William E, Carey, John, Carrasquillo, Olveen, Cassini, Thomas, Chang, Ta Chen Peter, Chanprasert, Sirisak, Chao, Hsiao-Tuan, Clark, Gary D, Coakley, Terra R, Cobban, Laurel A, Cogan, Joy D, Coggins, Matthew, Cole, F Sessions, Colley, Heather A, Cooper, Cynthia M, Cope, Heidi, Craigen, William J, Crouse, Andrew B, Cunningham, Michael, D'Souza, Precilla, Dai, Hongzheng, Dasari, Surendra, Davis, Joie, Dayal, Jyoti G, Deardorff, Matthew, Dell'Angelica, Esteban C, Dipple, Katrina, Doherty, Daniel, Dorrani, Naghmeh, Doss, Argenia L, Douine, Emilie D, Duncan, Laura, Earl, Dawn, Eckstein, David J, Emrick, Lisa T, Eng, Christine M, Esteves, Cecilia, Falk, Marni, Fernandez, Liliana, Fieg, Elizabeth L, and Fisher, Paul G
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Biological Sciences ,Bioinformatics and Computational Biology ,Genetics ,Pediatric ,Human Genome ,2.1 Biological and endogenous factors ,Adenosine Diphosphate ,Animals ,Histidine ,Humans ,Methyltransferases ,Mice ,Mice ,Inbred C57BL ,Neurodevelopmental Disorders ,Saccharomyces cerevisiae ,Saccharomyces cerevisiae Proteins ,Syndrome ,Nonverbal neurodevelopment delays ,Novel gene discovery ,Precision animal modeling ,Precision genomics ,Translational genetics ,Undiagnosed Diseases Network ,Clinical Sciences ,Genetics & Heredity - Abstract
PurposeDiphthamide is a post-translationally modified histidine essential for messenger RNA translation and ribosomal protein synthesis. We present evidence for DPH5 as a novel cause of embryonic lethality and profound neurodevelopmental delays (NDDs).MethodsMolecular testing was performed using exome or genome sequencing. A targeted Dph5 knockin mouse (C57BL/6Ncrl-Dph5em1Mbp/Mmucd) was created for a DPH5 p.His260Arg homozygous variant identified in 1 family. Adenosine diphosphate-ribosylation assays in DPH5-knockout human and yeast cells and in silico modeling were performed for the identified DPH5 potential pathogenic variants.ResultsDPH5 variants p.His260Arg (homozygous), p.Asn110Ser and p.Arg207Ter (heterozygous), and p.Asn174LysfsTer10 (homozygous) were identified in 3 unrelated families with distinct overlapping craniofacial features, profound NDDs, multisystem abnormalities, and miscarriages. Dph5 p.His260Arg homozygous knockin was embryonically lethal with only 1 subviable mouse exhibiting impaired growth, craniofacial dysmorphology, and multisystem dysfunction recapitulating the human phenotype. Adenosine diphosphate-ribosylation assays showed absent to decreased function in DPH5-knockout human and yeast cells. In silico modeling of the variants showed altered DPH5 structure and disruption of its interaction with eEF2.ConclusionWe provide strong clinical, biochemical, and functional evidence for DPH5 as a novel cause of embryonic lethality or profound NDDs with multisystem involvement and expand diphthamide-deficiency syndromes and ribosomopathies.
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- 2022
104. The Role of First-Language Heterogeneity in the Acquisition of Online Interaction Self-Efficacy in CSCL
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Natalia Reich-Stiebert, Jan-Bennet Voltmer, Jennifer Raimann, and Stefan Stürmer
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The acquisition of online interaction competencies is an important learning objective. The present study explored the relationships between the first-language heterogeneity of computer-supported collaborative learning (CSCL) groups and the development of students' online interaction self-efficacy via a pretest--posttest design in the context of a nine-week CSCL course. The research participants were 1525 freshmen receiving distance education who were randomly assigned to 343 CSCL groups. Independent of their own language status, students in CSCL groups featuring first-language heterogeneity exhibited lower precourse--postcourse gains in online interaction self-efficacy than students in groups without heterogeneity. Consistent with a theoretically derived moderation model, the relationships between first-language heterogeneity and self-efficacy gains were moderated by the amount of time that the groups spent on task-related communication during the initial collaboration phase (i.e., the relationships were significant when little time was spent on it but not when a great deal of time was spent on it). In contrast, the amount of time that groups spent on communication related to getting to know each other was ineffective as a significant moderator. Follow-up analyses indicated that time spent getting to know each other in first-language heterogeneous CSCL groups seems to have had the paradoxical effect of increasing rather than decreasing perceptions of heterogeneity among group members. Apparently, this effect impaired online interaction self-efficacy gains.
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- 2023
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105. Squeezing Quantum Many-Body Scars
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Windt, Bennet and Pichler, Hannes
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Quantum Physics - Abstract
We develop an analytical approach for the description of quantum many-body scars in PXP models. We show that the scarred dynamics in the PXP model on a complete bipartite graph can be interpreted as a one-dimensional chiral scattering problem, and solve this problem analytically. The insights from this analysis allow us to predict that dynamical signatures of scars in PXP models can be enhanced by spin squeezing the initial states. We show numerically that this stabilization mechanism applies not only to the complete bipartite graph but also to one- and two-dimensional lattices, which are relevant for Rydberg atom array experiments. Moreover, our findings provide a physical motivation for Hamiltonian deformations reminiscent of those known to produce perfect scars., Comment: 12 pages, 6 figures
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- 2021
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106. On the structure of regularization paths for piecewise differentiable regularization terms
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Gebken, Bennet, Bieker, Katharina, and Peitz, Sebastian
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Mathematics - Optimization and Control ,65F22, 62J07, 90C29, 49J52 - Abstract
Regularization is used in many different areas of optimization when solutions are sought which not only minimize a given function, but also possess a certain degree of regularity. Popular applications are image denoising, sparse regression and machine learning. Since the choice of the regularization parameter is crucial but often difficult, path-following methods are used to approximate the entire regularization path, i.e., the set of all possible solutions for all regularization parameters. Due to their nature, the development of these methods requires structural results about the regularization path. The goal of this article is to derive these results for the case of a smooth objective function which is penalized by a piecewise differentiable regularization term. We do this by treating regularization as a multiobjective optimization problem. Our results suggest that even in this general case, the regularization path is piecewise smooth. Moreover, our theory allows for a classification of the nonsmooth features that occur in between smooth parts. This is demonstrated in two applications, namely support-vector machines and exact penalty methods.
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- 2021
107. AGC 226178 and NGVS 3543: Two deceptive dwarfs towards Virgo
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Jones, Michael G., Sand, David J., Bellazzini, Michele, Spekkens, Kristine, Cannon, John M., Mutlu-Pakdil, Burçin, Karunakaran, Ananthan, Beccari, Giacomo, Magrini, Laura, Cresci, Giovanni, Inoue, John L., Fuson, Jackson, Adams, Elizabeth A. K., Battaglia, Giuseppina, Bennet, Paul, Crnojević, Denija, Caldwell, Nelson, Guhathakurta, Puragra, Haynes, Martha P., Muñoz, Ricardo R., Seth, Anil, Strader, Jay, Toloba, Elisa, and Zaritsky, Dennis
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Astrophysics - Astrophysics of Galaxies - Abstract
The two sources AGC 226178 and NGVS 3543, an extremely faint, clumpy, blue stellar system and a low surface brightness dwarf spheroidal, are adjacent systems in the direction of the Virgo cluster. Both have been studied in detail previously, with it being suggested that they are unrelated normal dwarf galaxies or that NGVS 3543 recently lost its gas through ram pressure stripping, and that AGC 226178 formed from this stripped gas. However, with HST ACS imaging we demonstrate that the stellar population of NGVS 3543 is inconsistent with being at the distance of the Virgo cluster, and that it is likely a foreground object at approximately 10 Mpc. Whereas the stellar population of AGC 226178 is consistent with it being a very young (10-100 Myr) object in the Virgo cluster. Through a re-analysis of the original ALFALFA HI detection we show that AGC 226178 likely formed from gas stripped from the nearby dwarf galaxy VCC 2034, a hypothesis strengthened by the high metallicity measured with MUSE VLT observations. However, it is unclear whether ram pressure or a tidal interaction is responsible for stripping the gas. AGC 226178 is one of at least five similar objects now known towards Virgo. These objects are all young and unlikely to remain visible for over ~500 Myr, suggesting that they are continually produced in the cluster., Comment: Accepted to ApJL
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- 2021
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108. Application of Time Separation Technique to Enhance C-arm CT Dynamic Liver Perfusion Imaging
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Haseljić, Hana, Kulvait, Vojtěch, Frysch, Robert, Hensen, Bennet, Wacker, Frank, Rose, Georg, and Werncke, Thomas
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Physics - Medical Physics ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Perfusion imaging is an interesting new modality for evaluation and assessment of the liver cancer treatment. C-Arm CT provides a possibility to perform perfusion imaging scans intra-operatively for even faster evaluation. The slow speed of the C-Arm CT rotation and the presence of the noise, however, have an impact on the reconstruction and therefore model based approaches have to be applied. In this work we apply the Time separation technique (TST), to denoise data, speed up reconstruction and improve resulting perfusion images. We show on animal experiment data that Dynamic C-Arm CT Liver Perfusion Imaging together with the processing of the data based on the TST provides comparable results to standard CT liver perfusion imaging., Comment: 5 pages, 8 figures, published in Proceedings of the 16th Virtual International Meeting on Fully 3D Image Reconstruction in Radiology and Nuclear Medicine 2021 arXiv:2110.04143
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- 2021
109. A characterization of two-dimensional Buchsbaum matching complexes
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Goeckner, Bennet, Herr, Fran, Jones II, Legrand, and Rowlands, Rowan
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Mathematics - Combinatorics ,05C70, 05E45, 13F55, 13H10 - Abstract
The matching complex $M(G)$ of a graph $G$ is the set of all matchings in $G$. A Buchsbaum simplicial complex is a generalization of both a homology manifold and a Cohen--Macaulay complex. We give a complete characterization of the graphs $G$ for which $M(G)$ is a two-dimensional Buchsbaum complex. As an intermediate step, we determine which graphs have matching complexes that are themselves connected graphs., Comment: Some material in Sections 3 and 4 have reordered to emphasize the main result of each section. Other small changes throughout based on referee feedback. To appear in the Electronic Journal of Combinatorics
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- 2021
110. Prosaccade and Antisaccade Behavior in Fragile X‐Associated Tremor/Ataxia Syndrome Progression
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McLennan, Yingratana A, Mosconi, Matthew W, McKenzie, Forrest J, Famula, Jessica, Krawchuk, Bennet, Kim, Kyoungmi, Clark, Courtney J, Hessl, David, Rivera, Susan M, Simon, Tony J, Tassone, Flora, and Hagerman, Randi J
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Rare Diseases ,Fragile X Syndrome ,Neurodegenerative ,Clinical Research ,Brain Disorders ,Intellectual and Developmental Disabilities (IDD) ,FXTAS ,prosaccade ,antisaccade ,eye movements ,inhibitory deficits ,inhibitory deficits. ,Clinical sciences - Abstract
BackgroundQuantitative measurement of eye movements can reveal subtle progression in neurodegenerative diseases.ObjectiveTo determine if quantitative measurements of eye movements may reveal subtle progression of fragile X-associated tremor and ataxia (FXTAS).MethodsProsaccade (PS) and antisaccade (AS) behavior was analyzed in 25 controls, 57 non-FXTAS carriers, and 46 carriers with FXTAS.ResultsSymptomatic individuals with FXTAS had longer AS latencies, increased rates of AS errors, and increased AS dysmetria relative to non-FXTAS carriers and controls. These deficits, along with PS latency and velocity, were greater in advanced FXTAS stages.ConclusionAS deficits differentiated FXTAS from non-FXTAS premutation carriers implicating top-down control and frontostriatal deterioration. However, the absence of group differences between non-FXTAS carriers and controls in AS and PS markers suggests saccade performance may not be a sensitive enough measure for detecting conversion to FXTAS, but instead more helpful as translational biomarkers of FXTAS progression.
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- 2022
111. 2.5D Thermometry Maps for MRI-guided Tumor Ablation
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Alpers, Julian, Reimert, Daniel L., Rötzer, Maximilian, Gerlach, Thomas, Gutberlet, Marcel, Wacker, Frank, Hensen, Bennet, and Hansen, Christian
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Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Fast and reliable monitoring of volumetric heat distribution during MRI-guided tumor ablation is an urgent clinical need. In this work, we introduce a method for generating 2.5D thermometry maps from uniformly distributed 2D MRI phase images rotated around the applicator's main axis. The images can be fetched directly from the MR device, reducing the delay between image acquisition and visualization. For reconstruction, we use a weighted interpolation on a cylindric coordinate representation to calculate the heat value of voxels in a region of interest. A pilot study on 13 ex vivo bio protein phantoms with flexible tubes to simulate a heat sink effect was conducted to evaluate our method. After thermal ablation, we compared the measured coagulation zone extracted from the post-treatment MR data set with the output of the 2.5D thermometry map. The results show a mean Dice score of 0.75+-0.07, a sensitivity of 0.77+-0.03, and a reconstruction time within 18.02ms+-5.91ms. Future steps should address improving temporal resolution and accuracy, e.g., incorporating advanced bioheat transfer simulations., Comment: 11 pages and 4 figures, submitted to and accepted by the 24th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2021)
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- 2021
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112. Sexing Caucasian 2D footprints using convolutional neural networks
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Budka, Marcin, Bennet, Matthew R., Reynolds, Sally, Barefoot, Shelby, Reel, Sarah, Reidy, Selina, and Walker, Jeremy
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Computer Science - Computer Vision and Pattern Recognition ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Footprints are left, or obtained, in a variety of scenarios from crime scenes to anthropological investigations. Determining the sex of a footprint can be useful in screening such impressions and attempts have been made to do so using single or multi landmark distances, shape analyses and via the density of friction ridges. Here we explore the relative importance of different components in sexing two-dimensional foot impressions namely, size, shape and texture. We use a machine learning approach and compare this to more traditional methods of discrimination. Two datasets are used, a pilot data set collected from students at Bournemouth University (N=196) and a larger data set collected by podiatrists at Sheffield NHS Teaching Hospital (N=2677). Our convolutional neural network can sex a footprint with accuracy of around 90% on a test set of N=267 footprint images using all image components, which is better than an expert can achieve. However, the quality of the impressions impacts on this success rate, but the results are promising and in time it may be possible to create an automated screening algorithm in which practitioners of whatever sort (medical or forensic) can obtain a first order sexing of a two-dimensional footprint.
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- 2021
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113. Predicting sepsis in multi-site, multi-national intensive care cohorts using deep learning
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Moor, Michael, Bennet, Nicolas, Plecko, Drago, Horn, Max, Rieck, Bastian, Meinshausen, Nicolai, Bühlmann, Peter, and Borgwardt, Karsten
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Computer Science - Machine Learning - Abstract
Despite decades of clinical research, sepsis remains a global public health crisis with high mortality, and morbidity. Currently, when sepsis is detected and the underlying pathogen is identified, organ damage may have already progressed to irreversible stages. Effective sepsis management is therefore highly time-sensitive. By systematically analysing trends in the plethora of clinical data available in the intensive care unit (ICU), an early prediction of sepsis could lead to earlier pathogen identification, resistance testing, and effective antibiotic and supportive treatment, and thereby become a life-saving measure. Here, we developed and validated a machine learning (ML) system for the prediction of sepsis in the ICU. Our analysis represents the largest multi-national, multi-centre in-ICU study for sepsis prediction using ML to date. Our dataset contains $156,309$ unique ICU admissions, which represent a refined and harmonised subset of five large ICU databases originating from three countries. Using the international consensus definition Sepsis-3, we derived hourly-resolved sepsis label annotations, amounting to $26,734$ ($17.1\%$) septic stays. We compared our approach, a deep self-attention model, to several clinical baselines as well as ML baselines and performed an extensive internal and external validation within and across databases. On average, our model was able to predict sepsis with an AUROC of $0.847 \pm 0.050$ (internal out-of sample validation) and $0.761 \pm 0.052$ (external validation). For a harmonised prevalence of $17\%$, at $80\%$ recall our model detects septic patients with $39\%$ precision 3.7 hours in advance.
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- 2021
114. Golimumab in Children with Chronic Recurrent Multifocal Osteomyelitis: A Case Series and Review of the Literature
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Yang, Claire, Rosenwasser, Natalie, Wang, Xing, Xu, Zheng, Scheck, Joshua, Boos, Markus D., Gupta, Deepti, Brandling-Bennet, Heather A., Sidbury, Robert, Iyer, Ramesh S., and Zhao, Yongdong
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- 2023
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115. Highly selective aromatization of light naphtha using mesoporous aluminosilicate catalysts and theoretical model for predicting activity
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Sujith, S., Vaishnavi, B. J., Kamath, Girish, Kumar, Ranjith R., Reddy, R. Sudarshan, Valavarasu, G., Ravishankar, Raman, Maradur, Sanjeev P., Bennet, C., and Shanbhag, Ganapati V.
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- 2023
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116. Clinical application of a scale to assess genomic healthcare empowerment (GEmS): Process and illustrative case examples
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McConkie‐Rosell, Allyn, Schoch, Kelly, Sullivan, Jennifer, Spillmann, Rebecca C, Cope, Heidi, Tan, Queenie K‐G, Palmer, Christina GS, Hooper, Stephen R, Shashi, Vandana, Acosta, Maria T, Adam, Margaret, Adams, David R, Agrawal, Pankaj B, Alejandro, Mercedes E, Alvey, Justin, Amendola, Laura, Andrews, Ashley, Ashley, Euan A, Azamian, Mahshid S, Bacino, Carlos A, Bademci, Guney, Baker, Eva, Balasubramanyam, Ashok, Baldridge, Dustin, Bale, Jim, Bamshad, Michael, Barbouth, Deborah, Bayrak‐Toydemir, Pinar, Beck, Anita, Beggs, Alan H, Behrens, Edward, Bejerano, Gill, Bennet, Jimmy, Berg‐Rood, Beverly, Bernstein, Jonathan A, Berry, Gerard T, Bican, Anna, Bivona, Stephanie, Blue, Elizabeth, Bohnsack, John, Bonnenmann, Carsten, Bonner, Devon, Botto, Lorenzo, Boyd, Brenna, Briere, Lauren C, Brokamp, Elly, Brown, Gabrielle, Burke, Elizabeth A, Burrage, Lindsay C, Butte, Manish J, Byers, Peter, Byrd, William E, Carey, John, Carrasquillo, Olveen, Chang, Ta Chen Peter, Chanprasert, Sirisak, Chao, Hsiao‐Tuan, Clark, Gary D, Coakley, Terra R, Cobban, Laurel A, Cogan, Joy D, Coggins, Matthew, Sessions Cole, F, Colley, Heather A, Cooper, Cynthia M, Craigen, William J, Crouse, Andrew B, Cunningham, Michael, D'Souza, Precilla, Dai, Hongzheng, Dasari, Surendra, Davids, Mariska, Dayal, Jyoti G, Deardorff, Matthew, Dell'Angelica, Esteban C, Dhar, Shweta U, Dipple, Katrina, Doherty, Daniel, Dorrani, Naghmeh, Douine, Emilie D, Draper, David D, Duncan, Laura, Earl, Dawn, Eckstein, David J, Emrick, Lisa T, Eng, Christine M, Esteves, Cecilia, Estwick, Tyra, Falk, Marni, Fernandez, Liliana, Ferreira, Carlos, Fieg, Elizabeth L, Findley, Laurie C, Fisher, Paul G, Fogel, Brent L, Forghani, Irman, Fresard, Laure, Gahl, William A, Glass, Ian, and Godfrey, Rena A
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Pediatric ,Biotechnology ,Human Genome ,Clinical Research ,Genetics ,Good Health and Well Being ,Child ,Delivery of Health Care ,Family ,Genomics ,Humans ,Parents ,Exome Sequencing ,exome and genomic sequencing ,undiagnosed disorders ,healthcare empowerment ,genetic counseling ,parental perspectives ,rare disorders ,Undiagnosed Disease Network ,Clinical Sciences ,Genetics & Heredity - Abstract
The Genome Empowerment Scale (GEmS), developed as a research tool, assesses perspectives of parents of children with undiagnosed disorders about to undergo exome or genome sequencing related to the process of empowerment. We defined genomic healthcare empowerment as follows: perceived ability to understand and seek new information related to the genomic sequencing, manage emotions related to the diagnostic process and outcomes, and utilize genomic sequencing information to the betterment of the individual/child and family. The GEmS consists of four scales, two are primarily emotion-focused (Meaning of a Diagnosis, and Emotional Management of the Process) and two are action-oriented (Seeking Information and Support, and Implications and Planning). The purpose of this research was to provide a strategy for interpreting results from the GEmS and present illustrative cases. These illustrations should serve to facilitate use of the GEmS in the clinical and research arena, particularly with respect to guiding genetic counseling processes for parents of children with undiagnosed conditions.
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- 2022
117. Urge intolerance predicts tic severity and impairment among adults with Tourette syndrome and chronic tic disorders
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Ramsey, Kesley A, De Nadai, Alessandro S, Espil, Flint M, Ricketts, Emily, Stiede, Jordan T, Schild, Jennifer, Specht, Matthew W, Woods, Douglas W, Bennet, Shannon, Walkup, John T, Chang, Susanna, Piacentini, John, and McGuire, Joseph F
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Biomedical and Clinical Sciences ,Clinical Sciences ,Brain Disorders ,Neurodegenerative ,Behavioral and Social Science ,Tourette Syndrome ,Mental Health ,Mind and Body ,Neurosciences ,Clinical Research ,premonitory urge ,distress tolerance ,adults ,impairment ,Public Health and Health Services ,Psychology ,Clinical sciences - Abstract
BackgroundIndividuals with Tourette Syndrome and Persistent Tic Disorders (collectively TS) often experience premonitory urges-aversive physical sensations that precede tics and are temporarily relieved by tic expression. The relationship between tics and premonitory urges plays a key role in the neurobehavioral treatment model of TS, which underlies first-line treatments such as the Comprehensive Behavioral Intervention for Tics (CBIT). Despite the efficacy of CBIT and related behavioral therapies, less than 40% of adults with TS respond to these treatments. Further examination of the relationship between premonitory urges, tic severity, and tic impairment can provide new insights into therapeutic targets to optimize behavioral treatment outcomes. This study examined whether urge intolerance-difficulty tolerating premonitory urges-predicted tic severity and tic-related impairment among adults with TS.MethodsParticipants were 80 adults with TS. Assessments characterized premonitory urge, distress tolerance, tic severity, and tic impairment. We used structural equation modeling (SEM) to examine the construct of urge intolerance-comprised of premonitory urge ratings and distress tolerance ratings. We first evaluated a measurement model of urge intolerance through bifactor modeling, including tests of the incremental value of subfactors that reflect premonitory urge severity and distress tolerance within the model. We then evaluated a structural model where we predicted clinician-rated tic severity and tic impairment by the latent variable of urge intolerance established in our measurement model.ResultsAnalyses supported a bifactor measurement model of urge intolerance among adults with TS. Consistent with theoretical models, higher levels of urge intolerance predicted greater levels of clinician-rated tic severity and tic impairment.ConclusionThis investigation supports the construct of urge intolerance among adults with TS and distinguishes it from subcomponents of urge severity and distress tolerance. Given its predictive relationship with tic severity and tic impairment, urge intolerance represents a promising treatment target to improve therapeutic outcomes in adults with TS.
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- 2022
118. The large inner Micromegas modules for the Atlas Muon Spectrometer Upgrade: construction, quality control and characterization
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Allard, J., Anfreville, M., Andari, N., Attié, D., Aune, S., Bachacou, H., Balli, F., Bauer, F., Bennet, J., Benoit, T., Beltramelli, J., Bervas, H., Bey, T., Bouaziz, S., Boyer, M., Challey, T., Chevalérias, T., Copollani, X., Costa, J., Cara, G., Decock, G., Deliot, F., Denysiuk, D., Desforge, D., Disset, G., Durand, G. A., Durand, R., Elman, J., Ribas, E. Ferrer, Fontaine, M., Formica, A., Gamache, W., Galán, J., Giganon, A., Giraud, J., Giraud, P. F., Glonti, G., Goblin, C., Graffin, P., Guillard, J. C., Hassani, S., Hervé, S., Javello, S., Jeanneau, F., Jourde, D., Jurie, S., Kebbiri, M., Kawamoto, T., Lampoudis, C., Laporte, J. F., Leboeuf, D., Lefevre, M., Lohan, M., Loiseau, C., Magnier, P., Mandjavidze, I., Manjarrés, J., Mas, P., Mur, M., Nikolaidou, R., Peyaud, A., Pierrepont, D., Piret, Y., Ponsot, P., Prono, G., Riallot, M., Rossi, F., Schune, P., Vacher, T., Vandenbroucke, M., Vigier, A., Vuillemin, C., Usseglio, M., and Wu, Z.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The steadily increasing luminosity of the LHC requires an upgrade with high-rate and high-resolution detector technology for the inner end cap of the ATLAS muon spectrometer: the New Small Wheels (NSW). In order to achieve the goal of precision tracking at a hit rate of about 15 kHz/cm$^2$ at the inner radius of the NSW, large area Micromegas quadruplets with 100\,\microns spatial resolution per plane have been produced. % IRFU, from the CEA research center of Saclay, is responsible for the production and validation of LM1 Micromegas modules. The construction, production, qualification and validation of the largest Micromegas detectors ever built are reported here. Performance results under cosmic muon characterisation will also be discussed., Comment: To be submitted to NIMA
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- 2021
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119. Satellites Around Milky Way Analogs: Tension in the Number and Fraction of Quiescent Satellites Seen in Observations Versus Simulations
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Karunakaran, Ananthan, Spekkens, Kristine, Oman, Kyle A., Simpson, Christine M., Fattahi, Azadeh, Sand, David J., Bennet, Paul, Crnojević, Denija, Frenk, Carlos S., Gómez, Facundo A., Grand, Robert J. J., Jones, Michael G., Marinacci, Federico, Mutlu-Pakdil, Burçin, Navarro, Julio F., and Zaritsky, Dennis
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Astrophysics - Astrophysics of Galaxies - Abstract
We compare the star-forming properties of satellites around Milky Way (MW) analogs from the Stage~II release of the Satellites Around Galactic Analogs Survey (SAGA-II) to those from the APOSTLE and Auriga cosmological zoom-in simulation suites. We use archival GALEX UV imaging as a star-formation indicator for the SAGA-II sample and derive star-formation rates (SFRs) to compare with those from APOSTLE and Auriga. We compare our detection rates from the NUV and FUV bands to the SAGA-II H$\alpha$ detections and find that they are broadly consistent with over $85\%$ of observed satellites detected in all three tracers. We apply the same spatial selection criteria used around SAGA-II hosts to select satellites around the MW-like hosts in APOSTLE and Auriga. We find very good overall agreement in the derived SFRs for the star-forming satellites as well as the number of star-forming satellites per host in observed and simulated samples. However, the number and fraction of quenched satellites in the SAGA-II sample are significantly lower than those in APOSTLE and Auriga below a stellar mass of $M_*\sim10^{8}\,M_{\odot}$, even when the SAGA-II incompleteness and interloper corrections are included. This discrepancy is robust with respect to the resolution of the simulations and persists when alternative star-formation tracers are employed. We posit that this disagreement is not readily explained by vagaries in the observed or simulated samples considered here, suggesting a genuine discrepancy that may inform the physics of satellite populations around MW analogs., Comment: Accepted for publication in ApJ Letters after minor changes to text
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- 2021
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120. Statistical inference for continuous-time locally stationary processes using stationary approximations
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Ströh, Bennet
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Mathematics - Statistics Theory ,Mathematics - Probability ,primary 62F10, 62F12, secondary 60G51, 62M09 - Abstract
We establish asymptotic properties of $M$-estimators, defined in terms of a contrast function and observations from a continuous-time locally stationary process. Using the stationary approximation of the sequence, $\theta$-weak dependence, and hereditary properties, we give sufficient conditions on the contrast function that ensure consistency and asymptotic normality of the $M$-estimator. As an example, we obtain consistency and asymptotic normality of a localized least squares estimator for observations from a sequence of time-varying L\'evy-driven Ornstein-Uhlenbeck processes. Furthermore, for a sequence of time-varying L\'evy-driven state space models, we show consistency of a localized Whittle estimator and an $M$-estimator that is based on a quasi maximum likelihood contrast. Simulation studies show the applicability of the estimation procedures.
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- 2021
121. Asymptotics of time-varying processes in continuous-time using locally stationary approximations
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Stelzer, Robert and Ströh, Bennet
- Subjects
Mathematics - Probability ,Mathematics - Statistics Theory ,primary 60F05, 60F25, 60G10, 60G51, secondary 62M09 - Abstract
We introduce a general theory on stationary approximations for locally stationary continuous-time processes. Based on the stationary approximation, we use $\theta$-weak dependence to establish laws of large numbers and central limit type results under different observation schemes. Hereditary properties for a large class of finite and infinite memory transformations show the flexibility of the developed theory. Sufficient conditions for the existence of stationary approximations for time-varying L\'evy-driven state space models are derived and compared to existing results. We conclude with comprehensive results on the asymptotic behavior of the first and second order localized sample moments of time-varying L\'evy-driven state space models.
- Published
- 2021
122. Continuous-time locally stationary time series models
- Author
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Bitter, Annemarie, Stelzer, Robert, and Ströh, Bennet
- Subjects
Mathematics - Probability ,Mathematics - Statistics Theory ,primary 60G07, 60G51, secondary 62M15 - Abstract
We adapt the classical definition of locally stationary processes in discrete-time to the continuous-time setting and obtain equivalent representations in the time and frequency domain. From this, a unique time-varying spectral density is derived using the Wigner-Ville spectrum. As an example, we investigate time-varying L\'evy-driven state space processes, including the class of time-varying L\'evy-driven CARMA processes. First, the connection between these two classes of processes is examined. Considering a sequence of time-varying L\'evy-driven state space processes, we then give sufficient conditions on the coefficient functions that ensure local stationarity with respect to the given definition.
- Published
- 2021
123. Evidence for Ultra-Diffuse Galaxy Formation Through Tidal Heating of Normal Dwarfs
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Jones, Michael G., Bennet, Paul, Mutlu-Pakdil, Burcin, Sand, David J., Spekkens, Kristine, Crnojevic, Denija, Karunakaran, Ananthan, and Zaritsky, Dennis
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We have followed up two ultra-diffuse galaxies (UDGs), detected adjacent to stellar streams, with Hubble Space Telescope (HST) imaging and HI mapping with the Jansky Very Large Array (VLA) in order to investigate the possibility that they might have a tidal origin. With the HST F814W and F555W images we measure the globular cluster (GC) counts for NGC 2708-Dw1 and NGC 5631-Dw1 as $2^{+1}_{-1}$ and $5^{+1}_{-2}$, respectively. NGC 2708-Dw1 is undetected in HI down to a 3$\sigma$ limit of $\log (M_\mathrm{HI}/\mathrm{M_\odot}) = 7.3$, and there is no apparent HI associated with the nearby stellar stream. There is a 2$\sigma$ HI feature coincident with NGC 5631-Dw1. However, this emission is blended with a large gaseous tail emanating from NGC 5631 and is not necessarily associated with the UDG. The presence of any GCs and the lack of clear HI connections between the UDGs and their parent galaxies strongly disfavor a tidal dwarf galaxy origin, but cannot entirely rule it out. The GC counts are consistent with those of normal dwarf galaxies, and the most probable formation mechanism is one where these UDGs were born as normal dwarfs and were later tidally stripped and heated. We also identify an over-luminous ($M_\mathrm{V} = -11.1$) GC candidate in NGC 2708-Dw1, which may be a nuclear star cluster transitioning to an ultra-compact dwarf as the surrounding dwarf galaxy gets stripped of stars., Comment: Accepted to ApJ
- Published
- 2021
- Full Text
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124. Investigating the Relationship Between Air Quality and COVID-19 Transmission
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Albrecht, Laura, Czarnecki, Paulina, and Sakelaris, Bennet
- Subjects
Statistics - Applications - Abstract
It is hypothesized that short-term exposure to air pollution may influence the transmission of aerosolized pathogens such as COVID-19. We used data from 23 provinces in Italy to build a generalized additive model to investigate the association between the effective reproductive number of the disease and air quality while controlling for ambient environmental variables and changes in human mobility. The model finds that there is a positive, nonlinear relationship between the density of particulate matter in the air and COVID-19 transmission, which is in alignment with similar studies on other respiratory illnesses., Comment: Supplementary materials available at: https://jds-online.org/journal/JDS/article/549/info
- Published
- 2021
- Full Text
- View/download PDF
125. Long-distance entanglement of purification and reflected entropy in conformal field theory
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Camargo, Hugo A., Hackl, Lucas, Heller, Michal P., Jahn, Alexander, and Windt, Bennet
- Subjects
High Energy Physics - Theory ,Condensed Matter - Statistical Mechanics ,Condensed Matter - Strongly Correlated Electrons ,Quantum Physics - Abstract
Quantifying entanglement properties of mixed states in quantum field theory via entanglement of purification and reflected entropy is a new and challenging subject. In this work, we study both quantities for two spherical subregions far away from each other in the vacuum of a conformal field theory in any number of dimensions. Using lattice techniques, we find an elementary proof that the decay of both, the entanglement of purification and reflected entropy, is enhanced with respect to the mutual information behaviour by a logarithm of the distance between the subregions. In the case of the Ising spin chain at criticality and the related free fermion conformal field theory, we compute also the overall coefficients numerically for the both quantities of interest., Comment: 5 pages, 2 figures + appendices; v2: previous results unchanged, added proof of the long-distance behaviour of EoP, reorganized presentation
- Published
- 2021
- Full Text
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126. Hubble Space Telescope Imaging of Isolated Local Volume Dwarfs GALFA-Dw3 and Dw4
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Bennet, P., Sand, D. J., Crnojević, D., Weisz, D. R., Caldwell, N., Guhathakurta, P., Hargis, J. R., Karunakaran, A., Mutlu-Pakdil, B., Olszewski, E., Salzer, J. J., Seth, A. C., Simon, J. D., Spekkens, K., Stark, D. P., Strader, J., Tollerud, E. J., Toloba, E., and Willman, B.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We present observations of the dwarf galaxies GALFA Dw3 and GALFA Dw4 with the Advanced Camera for Surveys (ACS) on the Hubble Space Telescope (HST). These galaxies were initially discovered as optical counterparts to compact HI clouds in the GALFA survey. Both objects resolve into stellar populations which display an old red giant branch, younger helium burning, and massive main sequence stars. We use the tip of the red giant branch method to determine the distance to each galaxy, finding distances of 7.61$_{-0.29}^{+0.28}$ Mpc and 3.10$_{-0.17}^{+0.16}$ Mpc, respectively. With these distances we show that both galaxies are extremely isolated, with no other confirmed objects within ~1.5 Mpc of either dwarf. GALFA Dw4 is also found to be unusually compact for a galaxy of its luminosity. GALFA Dw3 and Dw4 contain HII regions with young star clusters and an overall irregular morphology; they show evidence of ongoing star formation through both ultraviolet and H$\alpha$ observations and are therefore classified as dwarf irregulars (dIrrs). The star formation histories of these two dwarfs show distinct differences: Dw3 shows signs of a recently ceased episode of active star formation across the entire dwarf, while Dw4 shows some evidence for current star formation in spatially limited HII regions. Compact HI sources offer a promising method for identifying isolated field dwarfs in the Local Volume, including GALFA Dw3 & Dw4, with the potential to shed light on the driving mechanisms of dwarf galaxy formation and evolution., Comment: 18 pages, 7 figures, 1 table, submitted to ApJ
- Published
- 2021
- Full Text
- View/download PDF
127. Effects of systemic anticoagulation in a murine model of compensatory lung growth
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Yu, Lumeng J., Ko, Victoria H., Tsikis, Savas T., Dao, Duy T., Secor, Jordan D., Pan, Amy, Cho, Bennet S., Michell, Paul D., Fligor, Scott C., Kishikawa, Hiroko, and Puder, Mark
- Published
- 2023
- Full Text
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128. Gendered Mental Labor: A Systematic Literature Review on the Cognitive Dimension of Unpaid Work Within the Household and Childcare
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Reich-Stiebert, Natalia, Froehlich, Laura, and Voltmer, Jan-Bennet
- Published
- 2023
- Full Text
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129. Modelling maximum cyber incident losses of German organisations: an empirical study and modified extreme value distribution approach
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von Skarczinski, Bennet, Raschke, Mathias, and Teuteberg, Frank
- Published
- 2023
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130. Primary hyperparathyroidism in pregnancy: experience of a tertiary centre
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Arshad, Muhammad Fahad, Arambewela, Maulee Hiromi, Bennet, William M., Sterrenburg, Monique, and Balasubramanian, Saba P.
- Published
- 2023
- Full Text
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131. Three Quenched, Faint Dwarf Galaxies in the Direction of NGC 300: New Probes of Reionization and Internal Feedback
- Author
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David J. Sand, Burçin Mutlu-Pakdil, Michael G. Jones, Ananthan Karunakaran, Jennifer E. Andrews, Paul Bennet, Denija Crnojević, Giuseppe Donatiello, Alex Drlica-Wagner, Catherine Fielder, David Martínez-Delgado, Clara E. Martínez-Vázquez, Kristine Spekkens, Amandine Doliva-Dolinsky, Laura C. Hunter, Jeffrey L. Carlin, William Cerny, Tehreem N. Hai, Kristen B.W. McQuinn, Andrew B. Pace, and Adam Smercina
- Subjects
Dwarf galaxies ,Quenched galaxies ,Galaxy quenching ,Astrophysics ,QB460-466 - Abstract
We report the discovery of three faint and ultrafaint dwarf galaxies—Sculptor A, Sculptor B, and Sculptor C—in the direction of NGC 300 ( D = 2.0 Mpc), a Large Magellanic Cloud–mass galaxy. Deep ground-based imaging with Gemini/GMOS resolves all three dwarf galaxies into stars, each displaying a red giant branch indicative of an old, metal-poor stellar population. No young stars or H i gas are apparent, and the lack of a GALEX UV detection suggests that all three systems are quenched. Sculptor C ( D = 2.04 ${}_{-0.13}^{+0.10}$ Mpc; M _V = −9.1 ± 0.1 mag or L _V = (3.7 ${}_{-0.3}^{+0.4}$ ) × 10 ^5 L _⊙ ) is consistent with being a satellite of NGC 300. Sculptor A ( D = 1.35 ${}_{-0.08}^{+0.22}$ Mpc; M _V = −6.9 ± 0.3 mag or L _V = (5 ${}_{-1}^{+1}$ ) × 10 ^4 L _⊙ ) is likely in the foreground of NGC 300 and at the extreme edge of the Local Group, analogous to the recently discovered ultrafaint Tucana B in terms of its physical properties and environment. Sculptor B ( D = 2.48 ${}_{-0.24}^{+0.21}$ Mpc; M _V = −8.1 ± 0.3 mag or L _V = (1.5 ${}_{-0.4}^{+0.5}$ ) × 10 ^5 L _⊙ ) is likely in the background, but future distance measurements are necessary to solidify this statement. It is also of interest due to its quiescent state and low stellar mass. Both Sculptor A and B are ≳2–4 r _vir from NGC 300 itself. The discovery of three dwarf galaxies in isolated or low-density environments offers an opportunity to study the varying effects of ram-pressure stripping, reionization, and internal feedback in influencing the star formation history of the faintest stellar systems.
- Published
- 2024
- Full Text
- View/download PDF
132. On the Treatment of Optimization Problems with L1 Penalty Terms via Multiobjective Continuation
- Author
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Bieker, Katharina, Gebken, Bennet, and Peitz, Sebastian
- Subjects
Mathematics - Optimization and Control ,Computer Science - Machine Learning - Abstract
We present a novel algorithm that allows us to gain detailed insight into the effects of sparsity in linear and nonlinear optimization, which is of great importance in many scientific areas such as image and signal processing, medical imaging, compressed sensing, and machine learning (e.g., for the training of neural networks). Sparsity is an important feature to ensure robustness against noisy data, but also to find models that are interpretable and easy to analyze due to the small number of relevant terms. It is common practice to enforce sparsity by adding the $\ell_1$-norm as a weighted penalty term. In order to gain a better understanding and to allow for an informed model selection, we directly solve the corresponding multiobjective optimization problem (MOP) that arises when we minimize the main objective and the $\ell_1$-norm simultaneously. As this MOP is in general non-convex for nonlinear objectives, the weighting method will fail to provide all optimal compromises. To avoid this issue, we present a continuation method which is specifically tailored to MOPs with two objective functions one of which is the $\ell_1$-norm. Our method can be seen as a generalization of well-known homotopy methods for linear regression problems to the nonlinear case. Several numerical examples - including neural network training - demonstrate our theoretical findings and the additional insight that can be gained by this multiobjective approach., Comment: Accepted by IEEE TPAMI 2021
- Published
- 2020
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133. Analysis and fabrication of a photonic crystal based anti-reflective coating for photovoltaics generated by evolutionary optimization
- Author
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Bennet, Pauline, Juillet, Perrine, Ibrahim, Sara, Berhier, Vincent, Barry, Mamadou Aliou, Réveret, François, Bousquet, Angélique, Teytaud, Olivier, Centeno, Emmanuel, and Moreau, Antoine
- Subjects
Physics - Optics ,Physics - Applied Physics - Abstract
We optimize multilayered anti-reflective coatings for photovoltaic devices, using modern evolutionary algorithms. We apply a rigorous methodology to show that a given structure, which is particularly regular, emerge spontaneously in a very systematical way for a very broad range of conditions. The very regularity of the structure allows for a thorough physical analysis of how the designs operate. This allows to understand that the central part is a photonic crystal utilized as a buffer for light, and that the external layers have the purpose of reducing the impedance mismatch between the outer media and the Bloch mode supported by the photonic crystal. This shows how optimization can suggest new design rules and be considered as a source of inspiration. Finally, we fabricate these structures with easily deployable techniques.
- Published
- 2020
- Full Text
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134. OnionBot: A System for Collaborative Computational Cooking
- Author
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Cobley, Bennet and Boyle, David
- Subjects
Computer Science - Human-Computer Interaction ,Computer Science - Robotics - Abstract
An unsolved challenge in cooking automation is designing for shared kitchen workspaces. In particular, robots struggle with dexterity in the unstructured and dynamic kitchen environment. We propose that human-machine collaboration can be achieved without robotic manipulation. We describe a novel system design using computer vision to inform intelligent cooking interventions. This human-centered approach does not require actuators and promotes dynamic, natural collaboration. We show that automation that assists user-led actions can offer meaningful cooking assistance and can generate the image databases needed for fully autonomous robotic systems of the future. We provide an open source implementation of our work and encourage the research community to build upon it., Comment: 6 pages, 7 figures. Open source repository is available at https://github.com/onionbot
- Published
- 2020
135. Entanglement and Complexity of Purification in (1+1)-dimensional free Conformal Field Theories
- Author
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Camargo, Hugo A., Hackl, Lucas, Heller, Michal P., Jahn, Alexander, Takayanagi, Tadashi, and Windt, Bennet
- Subjects
High Energy Physics - Theory ,Condensed Matter - Statistical Mechanics ,Quantum Physics - Abstract
Finding pure states in an enlarged Hilbert space that encode the mixed state of a quantum field theory as a partial trace is necessarily a challenging task. Nevertheless, such purifications play the key role in characterizing quantum information-theoretic properties of mixed states via entanglement and complexity of purifications. In this article, we analyze these quantities for two intervals in the vacuum of free bosonic and Ising conformal field theories using, for the first time, the~most general Gaussian purifications. We provide a comprehensive comparison with existing results and identify universal properties. We further discuss important subtleties in our setup: the massless limit of the free bosonic theory and the corresponding behaviour of the mutual information, as well as the Hilbert space structure under the Jordan-Wigner mapping in the spin chain model of the Ising conformal field theory., Comment: 31 pages, 14 figures
- Published
- 2020
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- View/download PDF
136. Local optimization on pure Gaussian state manifolds
- Author
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Windt, Bennet, Jahn, Alexander, Eisert, Jens, and Hackl, Lucas
- Subjects
Quantum Physics ,Condensed Matter - Statistical Mechanics ,High Energy Physics - Theory - Abstract
We exploit insights into the geometry of bosonic and fermionic Gaussian states to develop an efficient local optimization algorithm to extremize arbitrary functions on these families of states. The method is based on notions of gradient descent attuned to the local geometry which also allows for the implementation of local constraints. The natural group action of the symplectic and orthogonal group enables us to compute the geometric gradient efficiently. While our parametrization of states is based on covariance matrices and linear complex structures, we provide compact formulas to easily convert from and to other parametrization of Gaussian states, such as wave functions for pure Gaussian states, quasiprobability distributions and Bogoliubov transformations. We review applications ranging from approximating ground states to computing circuit complexity and the entanglement of purification that have both been employed in the context of holography. Finally, we use the presented methods to collect numerical and analytical evidence for the conjecture that Gaussian purifications are sufficient to compute the entanglement of purification of arbitrary mixed Gaussian states., Comment: 33 pages, supplementary Mathematica package with example notebook (as ancillary file)
- Published
- 2020
- Full Text
- View/download PDF
137. Minkowski summands of cubes
- Author
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Castillo, Federico, Doolittle, Joseph, Goeckner, Bennet, Ross, Michael S., and Ying, Li
- Subjects
Mathematics - Combinatorics ,52B05, 52B35 - Abstract
In pioneering works of Meyer and of McMullen in the early 1970s, the set of Minkowski summands of a polytope was shown to be a polyhedral cone called the type cone. Explicit computations of type cones are in general intractable. Nevertheless, we show that the type cone of the product of simplices is the cone over a simplex. This remarkably simple result derives from insights about rainbow point configurations and the work of McMullen., Comment: 12 pages, 4 figures. Incorporated referee suggestions, minor edits throughout. This version focuses more on type cones of products of simplices than the previous version. Introduction has been partially rewritten to reflect this change. To appear in the Bulletin of the London Mathematical Society
- Published
- 2020
- Full Text
- View/download PDF
138. Soft X-Ray Observations of Quiescent Solar Active Regions using Novel Dual-zone Aperture X-ray Solar Spectrometer (DAXSS)
- Author
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Schwab, Bennet D., Sewell, Robert H. A., Woods, Thomas N., Caspi, Amir, Mason, James Paul, and Moore, Christopher
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
The Dual-zone Aperture X-ray Solar Spectrometer (DAXSS) was flown on 2018 June18 on the NASA 36.336 sounding rocket flight and obtained the highest resolution to date for solar soft X-ray (SXR) spectra over a broad energy range. This observation was during a time with quiescent (non-flaring) small active regions on the solar disk and when the 10.7 cm radio flux (F10.7) was 75 solar flux units (1 sfu = 10-22 W/m^2/Hz). The DAXSS instrument consists of a LASP-developed dual-zone aperture and a commercial X-ray spectrometer from Amptek that measures solar full-disk irradiance from 0.5-20 keV with a resolving power of 20 near 1 keV. This paper discusses the novel design of the spectrometer and the instrument characterization techniques. Additionally,the solar measurements obtained from the 2018 sounding rocket flight are analyzed using CHIANTI spectral models to fit the temperatures, emission measures, and relative elemental abundances of the solar corona plasma. The abundance of iron was found to be 35 percent higher than expected in the quiescent sun's corona suggesting either that our spectral models require additional sophistication or that the underlying atomic database may require updates. Future long-term systematic observations of this spectral range are needed. DAXSS will fly on the INSPIRESat-1 CubeSat in late-2020, and its SXR spectral data could provide further insight into the sources of coronal heating through modeling the changes of relative elemental abundances during developments of active regions and solar flaring events., Comment: 21 pages, 12 figures, Submitted to The Astrophysical Journal
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- 2020
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139. Central limit theorems for stationary random fields under weak dependence with application to ambit and mixed moving average fields
- Author
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Curato, Imma Valentina, Stelzer, Robert, and Ströh, Bennet
- Subjects
Mathematics - Statistics Theory ,Mathematics - Probability ,primary 60G10, 60G57, 60G60, 62M40, secondary 62F10, 62M30 - Abstract
We obtain central limit theorems for stationary random fields employing a novel measure of dependence called $\theta$-lex weak dependence. We show that this dependence notion is more general than strong mixing, i.e., it applies to a broader class of models. Moreover, we discuss hereditary properties for $\theta$-lex and $\eta$-weak dependence and illustrate the possible applications of the weak dependence notions to the study of the asymptotic properties of stationary random fields. Our general results apply to mixed moving average fields (MMAF in short) and ambit fields. We show general conditions such that MMAF and ambit fields, with the volatility field being an MMAF or a $p$-dependent random field, are weakly dependent. For all the models mentioned above, we give a complete characterization of their weak dependence coefficients and sufficient conditions to obtain the asymptotic normality of their sample moments. Finally, we give explicit computations of the weak dependence coefficients of MSTOU processes and analyze under which conditions the developed asymptotic theory applies to CARMA fields.
- Published
- 2020
140. Lattice polytopes from Schur and symmetric Grothendieck polynomials
- Author
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Bayer, Margaret, Goeckner, Bennet, Hong, Su Ji, McAllister, Tyrrell, Olsen, McCabe, Pinckney, Casey, Vega, Julianne, and Yip, Martha
- Subjects
Mathematics - Combinatorics - Abstract
Given a family of lattice polytopes, two common questions in Ehrhart Theory are determining when a polytope has the integer decomposition property and determining when a polytope is reflexive. While these properties are of independent interest, the confluence of these properties is a source of active investigation due to conjectures regarding the unimodality of the $h^\ast$-polynomial. In this paper, we consider the Newton polytopes arising from two families of polynomials in algebraic combinatorics: Schur polynomials and inflated symmetric Grothendieck polynomials. In both cases, we prove that these polytopes have the integer decomposition property by using the fact that both families of polynomials have saturated Newton polytope. Furthermore, in both cases, we provide a complete characterization of when these polytopes are reflexive. We conclude with some explicit formulas and unimodality implications of the $h^\ast$-vector in the case of Schur polynomials., Comment: 37 pages, 3 tables, 4 figures; Comments Welcome; Version 2: updated references to acknowledge one result was previously known, corrected values in Table 1 and reference correct OEIS sequence; Version 3: Final Version. To appear in Electronic Journal of Combinatorics
- Published
- 2020
141. An efficient descent method for locally Lipschitz multiobjective optimization problems
- Author
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Gebken, Bennet and Peitz, Sebastian
- Subjects
Mathematics - Optimization and Control ,90C29, 90C30, 90C56, 49J52 - Abstract
In this article, we present an efficient descent method for locally Lipschitz continuous multiobjective optimization problems (MOPs). The method is realized by combining a theoretical result regarding the computation of descent directions for nonsmooth MOPs with a practical method to approximate the subdifferentials of the objective functions. We show convergence to points which satisfy a necessary condition for Pareto optimality. Using a set of test problems, we compare our method to the multiobjective proximal bundle method by M\"akel\"a. The results indicate that our method is competitive while being easier to implement. While the number of objective function evaluations is larger, the overall number of subgradient evaluations is lower. Finally, we show that our method can be combined with a subdivision algorithm to compute entire Pareto sets of nonsmooth MOPs.
- Published
- 2020
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142. The Satellite Luminosity Function of M101 into the Ultra-Faint Dwarf Galaxy Regime
- Author
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Bennet, P., Sand, D. J., Crnojevic, D., Spekkens, K., Karunakaran, A., Zaritsky, D., and Mutlu-Pakdil, B.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We have obtained deep Hubble Space Telescope (HST) imaging of four faint and ultra-faint dwarf galaxy candidates in the vicinity of M101 - Dw21, Dw22, Dw23 and Dw35, originally discovered by Bennet et al. (2017). Previous distance estimates using the surface brightness fluctuation technique have suggested that these four dwarf candidates are the only remaining viable M101 satellites identified in ground based imaging out to the virial radius of M101 (D~250 kpc). Advanced Camera for Surveys imaging of all four dwarf candidates shows no associated resolved stellar populations, indicating that they are thus background galaxies. We confirm this by generating simulated HST color magnitude diagrams of similar brightness dwarfs at the distance of M101. Our targets would have displayed clear, resolved red giant branches with dozens of stars if they had been associated with M101. With this information, we construct a satellite luminosity function for M101, which is 90% complete to M_V=-7.7 mag and 50% complete to M_V=-7.4 mag, that extends into the ultra-faint dwarf galaxy regime. The M101 system is remarkably poor in satellites in comparison to the Milky Way and M31, with only eight satellites down to an absolute magnitude of M_V=-7.7 mag, compared to the 14 and 26 seen in the Milky Way and M31, respectively. Further observations of Milky Way analogs are needed to understand the halo-to-halo scatter in their faint satellite systems, and connect them with expectations from cosmological simulations., Comment: 9 Pages, 3 Figures, 1 Table, Accepted by ApJL
- Published
- 2020
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143. Evaluation of the adsorption behavior and divalent metal ions removal efficiency of ceramic point-of-use water filter materials
- Author
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Apea, Ohene B., Akorley, Bennet Edem, Oyelude, Emmanuel O., and Ampadu, Boateng
- Published
- 2023
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144. The association of copeptin with metabolic risk markers is modified by region of origin
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Franzén, Anna, Pikkemaat, Miriam, Melander, Olle, Bennet, Louise, and Enhörning, Sofia
- Published
- 2023
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145. A 10-year update to the principles for clinical trial data sharing by pharmaceutical companies: perspectives based on a decade of literature and policies
- Author
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Modi, Natansh D., Kichenadasse, Ganessan, Hoffmann, Tammy C., Haseloff, Mark, Logan, Jessica M., Veroniki, Areti A., Venchiarutti, Rebecca L., Smit, Amelia K., Tuffaha, Haitham, Jayasekara, Harindra, Manning-Bennet, Arkady, Morton, Erin, McKinnon, Ross A., Rowland, Andrew, Sorich, Michael J., and Hopkins, Ashley M.
- Published
- 2023
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146. Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model
- Author
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Uchida, Naoya, Stasula, Ulana, Demirci, Selami, Germino-Watnick, Paula, Hinds, Malikiya, Le, Anh, Chu, Rebecca, Berg, Alexander, Liu, Xiong, Su, Ling, Wu, Xiaolin, Krouse, Allen E., Linde, N. Seth, Bonifacino, Aylin, Hong, So Gun, Dunbar, Cynthia E., Lanieri, Leanne, Bhat, Anjali, Palchaudhuri, Rahul, Bennet, Bindu, Hoban, Megan, Bertelsen, Kirk, Olson, Lisa M., Donahue, Robert E., and Tisdale, John F.
- Published
- 2023
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147. First experiences using transurethral ultrasound ablation (TULSA) as a promising focal approach to treat localized prostate cancer: a monocentric study
- Author
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Peters, Inga, Hensen, Bennet, Glandorf, Julian, Gutberlet, Marcel, Dohna, Martha, Struckmann, Steffen, Kuczyk, Markus Antonius, Wacker, Frank, and Hellms, Susanne
- Published
- 2023
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148. Ex vivo intestinal permeability assay (X-IPA) for tracking barrier function dynamics
- Author
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Bootz-Maoz, Hadar, Simon, Ariel, Del Mare-Roumani, Sara, Bennet, Yifat, Toister, Einat, Romano, Hadar, Zheng, Danping, Amidror, Sivan, Elinav, Eran, and Yissachar, Nissan
- Published
- 2023
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149. Automated prioritization of sick newborns for whole genome sequencing using clinical natural language processing and machine learning
- Author
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Peterson, Bennet, Hernandez, Edgar Javier, Hobbs, Charlotte, Malone Jenkins, Sabrina, Moore, Barry, Rosales, Edwin, Zoucha, Samuel, Sanford, Erica, Bainbridge, Matthew N., Frise, Erwin, Oriol, Albert, Brunelli, Luca, Kingsmore, Stephen F., and Yandell, Mark
- Published
- 2023
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150. Cancer, cardiovascular disease, and all-cause mortality in Iraqi- and Swedish-born individuals in Sweden: the MEDIM cohort study
- Author
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Dhaher, Nadine Fadhel, Pikkemaat, Miriam, Shaat, Nael, Nilsson, Anton, and Bennet, Louise
- Published
- 2023
- Full Text
- View/download PDF
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