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101. Phantosmia May Predict Long‐Term Measurable Olfactory Dysfunction After COVID ‐19

Author

Leung, Jai‐Sen, primary, Cordano, Valentina Paz, additional, Fuentes‐López, Eduardo, additional, Lagos, Antonia Elisa, additional, García‐Huidobro, Francisco Gustavo, additional, Aliaga, Rodrigo, additional, Díaz, Luis Antonio, additional, García‐Salum, Tamara, additional, Salinas, Erick, additional, Toro, Adriana, additional, Callejas, Claudio Andrés, additional, Riquelme, Arnoldo, additional, Palmer, James N., additional, Medina, Rafael A., additional, and González G, Claudia, additional

Published
2022
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104. Multi‐institutional review of sinonasal and skull base chondrosarcoma: 20‐year experience

Author

Eide, Jacob G., primary, Kshirsagar, Rijul S., additional, Harris, Jacob C., additional, Civantos, Alyssa, additional, Brody, Robert M., additional, Lee, John Y. K., additional, Alonso‐Basanta, Michelle, additional, Lazor, Jillian W., additional, Nabavizadeh, Ali, additional, Wang, Beverly Y., additional, Kuan, Edward C., additional, Palmer, James N., additional, and Adappa, Nithin D., additional

Published
2022
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107. In‐Hospital Costs for Open versus Endoscopic Endonasal Approach for Craniopharyngioma Resection

Author

Parasher, Arjun K, primary, Lerner, David K, additional, Miranda, Stephen P., additional, Douglas, Jennifer E., additional, Glicksman, Jordan T, additional, Alexander, Tyler, additional, Lin, Theodore, additional, Ebesutani, Darren, additional, Kohanski, Michael, additional, Lee, John YK, additional, Storm, Phillip B, additional, O'Malley, Bert W, additional, Yoshor, Daniel, additional, Palmer, James N, additional, Grady, M Sean, additional, and Adappa, Nithin D, additional

Published
2022
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108. Biofilms

Author

Woodworth, Bradford A., Palmer, James N., Önerci, T. Metin, editor, and Ferguson, Berrylin J., editor

Published
2010
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109. Biofilms

Author

Woodworth, Bradford A., Cohen, Noam A., Palmer, James N., Stucker, Fred J., editor, de Souza, Chris, editor, Kenyon, Guy S., editor, Lian, Timothy S., editor, Draf, Wolfgang, editor, and Schick, Bernhard, editor

Published
2009
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110. Recurrent Mucoceles

Author

Bleier, Benjamin, Palmer, James N., Woodworth, Bradford A., Kountakis, Stilianos, Jacobs, Joseph, and Gosepath, Jan

Published
2008
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115. Determinants of Patient Refusal of Postoperative Radiation Therapy in Sinonasal Squamous Cell Carcinoma.

Author

Kshirsagar, Rijul S., Eide, Jacob G., Prasad, Aman, Carey, Ryan M., Rajasekaran, Karthik, Brant, Jason A., Newman, Jason G., Palmer, James N., and Adappa, Nithin D.

Subjects
PROPORTIONAL hazards models, SQUAMOUS cell carcinoma, PROGRESSION-free survival, PARANASAL sinuses, RADIOTHERAPY, OLDER patients
Abstract

Objectives Although adjuvant radiotherapy may be indicated in patients with sinonasal squamous cell carcinoma (SNSCC) following primary surgery, some patients choose to forgo recommended postoperative radiation therapy (PORT). This study aimed to elucidate factors associated with patient refusal of recommended PORT in SNSCC and examine overall survival. Methods Retrospective analysis of patients with SNSCC treated with primary surgery from the National Cancer Database diagnosed between 2004 and 2016. A multivariable logistic regression model was created to determine the association between clinical or demographic covariates and likelihood of PORT refusal. Unadjusted Kaplan–Meier estimates, log-rank tests, and a multivariable Cox proportional hazard model were used to assess overall survival. Results A total of 2,231 patients were included in the final analysis, of which 1,456 (65.3%) were males and 73 (3.3%) refused recommended PORT. Patients older than 74 years old were more likely to refuse PORT than those younger than 54 (odds ratio [OR] 3.43, 95% confidence interval [CI]: 1.84–6.62). Median survival among the entire cohort, those who received recommended PORT, and those who refused PORT was 83.0 months (95% CI: 74.6–97.1), 83.0 months (95% CI: 74.9–98.2), and 63.6 months (95% CI: 37.3–101.4), respectively. Refusal of PORT was not associated with overall survival (hazard ratio: 0.99, 95% CI: 0.69–1.42). Conclusions PORT refusal in patients with SNSCC is rare and was found to be associated with several patient factors. The decision to forgo PORT is not independently associated with overall survival in this cohort. Further study is required to determine the clinical implications of these findings as the treatment decisions are complex. [ABSTRACT FROM AUTHOR]

Published
2023
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116. Image‐Guided Surgical Device Failures in Functional Endoscopic Sinus Surgery: A MAUDE Analysis.

Author

Hassanin, Samir W., Kshirsagar, Rijul S., Eide, Jacob G., Chang, Jeremy, Liang, Jonathan, Palmer, James N., and Adappa, Nithin D.

Abstract

Objective: Image‐guided surgery (IGS) devices have become widely used for anatomic localization during functional endoscopic sinus surgery (FESS). However, there are no studies that analyze the post‐market complications associated with IGS device use during FESS. The objective of this study was to better characterize post‐market complications associated with the use of IGS devices during sinus surgery. Methods: The US Food and Drug Administration's Manufacturer and User Facility Device Experience database was queried for event reports associated with neurological stereotaxic devices utilized in IGS between the dates of January 1, 2016 and December 31, 2020. Medical device reports that were analyzed for this study pertained strictly to FESS. Results: There were 1873 reports involving IGS devices for FESS included in this study. Fifty‐five reports involved adverse events to patients (2.9%) and 1818 (97.1%) involved device malfunctions. Of the adverse events to patients, the most common included cerebrospinal fluid leakage (45.6%), tissue damage (12.7%), and nervous system injury (3.6%). The most commonly reported device malfunction was imprecision (21.1%). Conclusion: IGS devices are widely utilized in FESS. Of the medical device reports between 2016 and 2020, less than 3% resulted in adverse events. Further studies of the infrequent post‐market complications of IGS devices used in FESS can help guide surgeons on the risks of their clinical use. Level of Evidence: 4—Retrospective database survey without controls Laryngoscope, 133:1310–1314, 2023 [ABSTRACT FROM AUTHOR]

Published
2023
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117. In-Hospital Cost Comparison for Open Versus Endoscopic Endonasal Approach for Meningioma Resection.

Author

Parasher, Arjun K., Lerner, David K., Miranda, Stephen P., Douglas, Jennifer E., Glicksman, Jordan T., Alexander, Tyler, Lin, Theodore, Ebesutani, Darren, Kohanski, Michael, Lee, John Y.K., Storm, Phillip B., O'Malley Jr., Bert W., Yoshor, Daniel, Palmer, James N., Grady, M. Sean, and Adappa, Nithin D.

Subjects
CONSUMER price indexes, MENINGIOMA, SKULL base, LENGTH of stay in hospitals, ELECTRONIC health records
Abstract

Objective: To determine the in-hospital cost implications of an endoscopic expanded endonasal approach (EEEA) for meningioma resection relative to the open transcranial approach. Methods: All anterior skull base meningioma surgeries performed over a period from January 1st, 2015 to October 31th, 2017 were evaluated. The electronic medical record was reviewed for patient factors, tumor characteristics, and cost variables associated with each hospital stay and univariate analysis was performed using R software. All cost data were converted into August 2021-equivalent dollar amounts using the United States Bureau of Labor Statistics consumer price index. Results: Thirty-five patients met study criteria, including 27 patients undergoing an open transcranial approach and 8 undergoing an EEEA. Average length of stay for patients undergoing an open approach was 9.3 days compared to 5.6 within the EEEA group (P =.126). The average total in-hospital cost of patient undergoing an EEEA was $35417.1 compared to $46406.9 among patients undergoing an open transcranial approach (P =.168). On univariate analysis, the cost of an open transcranial approach relative to the EEEA was $10989.8 (P =.411). Conclusions: The open transcranial approach remained the dominant surgical approach to anterior skull base meningiomas over our study time period. However, despite limited patient numbers the EEEA was associated with decreased total in-hospital costs. [ABSTRACT FROM AUTHOR]

Published
2023
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137. Long‐term outcomes in sinonasal squamous cell carcinoma arising from inverted papilloma: Systematic review

Author

Birkenbeuel, Jack L., primary, Pang, Jonathan C., additional, Lee, Ariel, additional, Nguyen, Emily S., additional, Risbud, Adwight, additional, Goshtasbi, Khodayar, additional, Abiri, Arash, additional, Lehrich, Brandon M., additional, Tong, Charles C. L., additional, Adappa, Nithin D., additional, Palmer, James N., additional, and Kuan, Edward C., additional

Published
2022
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138. Outcomes after Endoscopic Resection of Inverted Papilloma Based on Preoperative Lund-Mackay Score

Author

Ungerer, Heather N., additional, Tripathi, Siddhant, additional, Salmon, Mandy K., additional, Prasad, Aman, additional, Stevens, Elizabeth M., additional, Davin, Kathleen M., additional, Ig-Izevbekhai, Kevin, additional, Sweis, Auddie M., additional, Locke, Tran B., additional, Kohanski, Michael A., additional, Palmer, James N., additional, and Adappa, Nithin D., additional

Published
2022
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140. Postoperative Cerebrospinal Fluid Leaks following No Intraoperative Leak: A Multi-institutional Study

Author

Kshirsagar, Rijul S., additional, Asmaro, Karam P., additional, Eide, Jacob G., additional, Filip, Peter, additional, Pangal, Dhiraj, additional, Ruzevik, Jacob, additional, Adappa, Nithin D., additional, Batra, Pete S., additional, Bergsneider, Marvin, additional, Fernandez-Miranda, Juan C., additional, Gardner, Paul A., additional, Grady, M. S., additional, Hsu, Frank P., additional, Mohyeldin, Ahmed, additional, Palmer, James N., additional, Papagiannopoulos, Peter, additional, Snyderman, Carl H., additional, Tajudeen, Bobby A., additional, Wang, Eric W., additional, Wang, Marilene B., additional, Zada, Gabriel, additional, Zenonos, Georgios A., additional, and Kuan, Edward C., additional

Published
2022
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146. Determinants of Survival in Skull Base Chondrosarcoma: A National Cancer Database Study

Author

Merna, Catherine, primary, Lehrich, Brandon M., additional, Kshirsagar, Rijul S., additional, Eide, Jacob G., additional, Diaz-Aguilar, Luis Daniel, additional, Goshtasbi, Khodayar, additional, Yasaka, Tyler M., additional, Sahyouni, Ronald, additional, Palmer, James N., additional, Adappa, Nithin D., additional, Hsu, Frank P.K., additional, and Kuan, Edward C., additional

Published
2022
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147. Additional file 1 of Small-molecule Akt-activation in airway cells induces NO production and reduces IL-8 transcription through Nrf-2

Author

Gopallawa, Indiwari, Kuek, Li Eon, Adappa, Nithin D., Palmer, James N., and Lee, Robert J.

Abstract

Additional file 1: Figure S1. Co-localization and expression of glut1 and eNOS in A549 cells. IF was performed for GLUT1 (SLC2A1) and eNOS as described in the main text. (a) Secondary antibody only control, (b) glut-1 (cyan) and eNOs (magenta) localized largely to the plasma membrane, and (c) Line-scan showing colocalization of glut1 and eNOS. Scale bar is 10 μm. Figure S2. Inhibition of PI3K with 1μg/ml LY294002 reverses SC79-induced p-Akt. A549s were treated with SC79 (10μg/ml; DMSO only as control) or PI3K inhibitor LY294002 (1μg/ml) for 1 h before incubating with SC79 for 2 h. Cell lysates were collected for Western. Bars are means ± SEM; n = 3 experiments. (a) *p

Published
2022
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148. Carcinosarcoma of the nasal cavity and paranasal sinuses: Review of the national cancer database

Author

Harris, Jacob C., Eide, Jacob G., Kshirsagar, Rijul S., Brant, Jason A., Palmer, James N., and Adappa, Nithin D.

Abstract

Carcinosarcomas are rare, aggressive malignancies that can arise in the nasal cavity and paranasal sinuses. There are limited outcome data available. Accordingly, we sought to use the National Cancer Database (NCDB) to characterize patient demographics and outcomes. A retrospective analysis of the NCDB from 2004 to 2016 for patients with sinonasal carcinosarcoma was conducted. Thirty patients were included. The patients were predominantly male (n= 20), white (n= 23), and privately insured (n= 15), with an average age of 62.4 years. The nasal cavity was the most common subsite (n= 14), followed by the maxillary sinus (n= 8). Most patient were treated with surgery followed by radiation (n= 23), with the remaining undergoing surgery alone (n= 4), radiation alone (n= 2), or no treatment (n= 1). One‐third (n= 10) received adjuvant chemotherapy. The 1‐ and 5‐year overall survival (OS) in the cohort were 79.2% and 43.3%, respectively. Univariate log‐rank testing showed OS varied based on intervention (P< 0.029), sex (P< 0.042), and age (P< 0.025), while on multivariate analysis none of these factors independently predicted OS. We describe the demographics and presenting features of a national cohort of sinonasal carcinosarcoma patients. Future research is needed to identify predictors of overall survival, and to assess the optimal roles for radiation and systemic chemotherapy. The demographics and outcomes for a cohort of 30 patients with sinonasal carcinosarcoma were described.Seventy‐six percent of patients were treated with surgery followed by adjuvant radiotherapy.1‐ and 5‐year survival from the time of diagnosis were 79.2% and 43.3% respectively.Neither surgical intervention, patient sex, nor patient age independently predicted survival outcomes. The demographics and outcomes for a cohort of 30 patients with sinonasal carcinosarcoma were described. Seventy‐six percent of patients were treated with surgery followed by adjuvant radiotherapy. 1‐ and 5‐year survival from the time of diagnosis were 79.2% and 43.3% respectively. Neither surgical intervention, patient sex, nor patient age independently predicted survival outcomes.

Published
2023
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150. Steroid affected cytokines in aspirin‐exacerbated respiratory disease

Author

Tan, Li Hui, primary, Lin, Cailu, additional, Ungerer, Heather, additional, Kumar, Ankur, additional, Qatanani, Anas, additional, Adappa, Nithin D., additional, Palmer, James N., additional, Bosso, John V., additional, Reed, Danielle, additional, Cohen, Noam A., additional, and Kohanski, Michael A., additional

Published
2022
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