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637 results on '"Piazza, V."'

101. Recurrent ETNK1 mutations in atypical chronic myeloid leukemia

Author

Gambacorti-Passerini, C.B. Donadoni, C. Parmiani, A. Pirola, A. Redaelli, S. Signore, G. Piazza, V. Malcovati, L. Fontana, D. Spinelli, R. Magistroni, V. Gaipa, G. Peronaci, M. Morotti, A. Panuzzo, C. Saglio, G. Usala, E. Kim, D.-W. Rea, D. Zervakis, K. Viniou, N. Symeonidis, A. Becker, H. Boultwood, J. Campiotti, L. Carrabba, M. Elli, E. Bignell, G.R. Papaemmanuil, E. Campbell, P.J. Cazzola, M. Piazza, R.

Abstract

Despite the recent identification of recurrent SETBP1 mutations in atypical chronic myeloid leukemia (aCML), a complete description of the somatic lesions responsible for the onset of this disorder is still lacking. To find additional somatic abnormalities in aCML, we performed whole-exome sequencing on 15 aCML cases. In 2 cases (13.3%), we identified somatic missense mutations in the ETNK1 gene. Targeted resequencing on 515 hematological clonal disorders revealed the presence of ETNK1 variants in 6 (8.8%) of 68 aCML and 2 (2.6%) of 77 chronic myelomonocytic leukemia samples. These mutations clustered in a small region of the kinase domain, encoding for H243Y and N244S (1/8 H243Y; 7/8 N244S). They were all heterozygous and present in the dominant clone. The intracellular phosphoethanolamine/phosphocholine ratio was, on average, 5.2-fold lower in ETNK1-mutated samples ( P < .05). Similar results were obtained using myeloid TF1 cells transduced with ETNK1 wild type, ETNK1-N244S, and ETNK1-H243Y, where the intracellular phosphoethanolamine/phosphocholine ratio was significantly lower in ETNK1-N244S (0.76 ± 0.07) and ETNK1-H243Y (0.37 ± 0.02) than in ETNK1-WT (1.37 ± 0.32; P = .01 and P = .0008, respectively), suggesting that ETNK1 mutations may inhibit the catalytic activity of the enzyme. In summary, our study shows for the first time the evidence of recurrent somatic ETNK1 mutations in the context of myeloproliferative/myelodysplastic disorders. © 2015 by The American Society of Hematology.

Published
2015

102. Age-related changes in the function and structure of the peripheral sensory pathway in mice

Author

Canta, A, Chiorazzi, A, Carozzi, V, Meregalli, C, Oggioni, N, Bossi, M, RODRIGUEZ MENENDEZ, V, Avezza, F, Crippa, L, Lombardi, R, de Vito, G, Piazza, V, Cavaletti, G, Marmiroli, P, CANTA, ANNALISA ROSANNA, CHIORAZZI, ALESSIA, CAROZZI, VALENTINA ALDA, MEREGALLI, CRISTINA, OGGIONI, NORBERTO, BOSSI, MARIO, RODRIGUEZ MENENDEZ, VIRGINIA, AVEZZA, FEDERICA, CAVALETTI, GUIDO ANGELO, MARMIROLI, PAOLA LORENA, Canta, A, Chiorazzi, A, Carozzi, V, Meregalli, C, Oggioni, N, Bossi, M, RODRIGUEZ MENENDEZ, V, Avezza, F, Crippa, L, Lombardi, R, de Vito, G, Piazza, V, Cavaletti, G, Marmiroli, P, CANTA, ANNALISA ROSANNA, CHIORAZZI, ALESSIA, CAROZZI, VALENTINA ALDA, MEREGALLI, CRISTINA, OGGIONI, NORBERTO, BOSSI, MARIO, RODRIGUEZ MENENDEZ, VIRGINIA, AVEZZA, FEDERICA, CAVALETTI, GUIDO ANGELO, and MARMIROLI, PAOLA LORENA

Abstract

This study is aimed at describing the changes occurring in the entire peripheral nervous system sensory pathway along a 2-year observation period in a cohort of C57BL/6 mice. The neurophysiological studies evidenced significant differences in the selected time points corresponding to childhood, young adulthood, adulthood, and aging (i.e., 1, 7, 15, and 25 months of age), with a parabolic course as function of time. The pathological assessment allowed to demonstrate signs of age-related changes since the age of 7 months, with a remarkable increase in both peripheral nerves and dorsal root ganglia at the subsequent time points. These changes were mainly in the myelin sheaths, as also confirmed by the Rotating-Polarization Coherent-Anti-stokes-Raman-scattering microscopy analysis. Evident changes were also present at the morphometric analysis performed on the peripheral nerves, dorsal root ganglia neurons, and skin biopsies. This extensive, multimodal characterization of the peripheral nervous system changes in aging provides the background for future mechanistic studies allowing the selection of the most appropriate time points and readouts according to the investigation aims.

Published
2016

109. The effect of on-line high-flux hemofiltration versus low-flux hemodialysis on mortality in chronic kidney failure: a small randomized controlled trial

Author

Santoro A., Mancini E., Boggi R., Cagnoli L., Francioso A., Fusaroli M., Piazza V., Rapanà R., Strippoli G. F., BOLZANI, ROBERTO, Santoro A., Mancini E., Bolzani R., Boggi R., Cagnoli L., Francioso A., Fusaroli M., Piazza V., Rapanà R., and Strippoli G.F.

Subjects
HEMODIALYSIS, DIALYSIS ADEQUACY, HEMOFILTRATION, HIGH FLUX
Abstract

Background: Given the paucity of prospective randomized controlled trials assessing comparative performances of different dialysis techniques, we compared on-line high-flux hemofiltration (HF) with ultrapure low-flux hemodialysis (HD), assessing survival and morbidity in patients with end-stage renal disease (ESRD). Study Design: An investigator-driven, prospective, multicenter, 3-year-follow-up, centrally randomized study with no blinding and based on the intention-to-treat principle. Setting & Participants: Prevalent patients with ESRD (age, 16 to 80 years; vintage > 6 months) receiving renal replacement therapy at 20 Italian dialysis centers. Interventions: Patients were centrally randomly assigned to HD (n = 32) or HF (n = 32). Outcomes & Measurements: All-cause mortality, hospitalization rate for any cause, prevalence of dialysis hypotension, standard biochemical indexes, and nutritional status. Analyses were performed using the multivariate analysis of variance and Cox proportional hazard method. Results: There was significant improvement in survival with HF compared with HD (78%, HF versus 57%, HD) at 3 years of follow-up after allowing for the effects of age (P < 0.05). End-of-treatment Kt/V was significantly higher with HD (1.42 ± 0.06 versus 1.07 ± 0.06 with HF), whereas β2-microglobulin levels remained constant in HD patients (33.90 ± 2.94 mg/dL at baseline and 36.90 ± 5.06 mg/dL at 3 years), but decreased significantly in HF patients (30.02 ± 3.54 mg/dL at baseline versus 23.9 ± 1.77 mg/dL; P < 0.05). The number of hospitalization events for each patient was not significantly different (2.36 ± 0.41 versus 1.94 ± 0.33 events), whereas length of stay proved to be significantly shorter in HF patients compared with HD patients (P < 0.001). End-of-treatment body mass index decreased in HD patients, but increased in HF patients. Throughout the study period, the difference in trends of intradialytic acute hypotension was statistically significant, with a clear decrease in HF (P < 0.03). Limitations: This is a small preliminary intervention study with a high dropout rate and problematic generalizability. Conclusion: On-line HF may improve survival independent of Kt/V in patients with ESRD, with a significant decrease in plasma β2-microglobulin levels and increased body mass index. A larger study is required to confirm these results.

Published
2008

110. Method and device for measuring position and mass

Author

BELTRAM, Fabio, PINGUE, Pasqualantonio, BIASIOL G, PIAZZA V, SORBA L, STRAMBINI E., Beltram, Fabio, Biasiol, G, Piazza, V, Pingue, Pasqualantonio, Sorba, L, and Strambini, E.

Published
2008

111. Studio degli indicatori di risultato multipli nella popolazione affetta da irc in terapia conservativa (SIR-SIN). Risultati del questionario KDQOL-SF (Kidney Disease Quality of Life Short Form) sulla qualità della vita

Author

Locatelli F, Zoccali C, Catucci AE, Minutolo R, De Nicola L, Grillo C, Beltrame A, Fagugli R, Catizone L, Mancini W, Di Luzio V, Brigante M, Battaglia G, Adorati Menegato M, Bonfante L, Parravano M, Ronco C, Farina M, Spotti D, De Santo NG, Moriconi L, Bellinghieri G, Ricciardi B, Costanzo R, Conti M, Piazza V, Dal Canton A, Corti MM, Della Grotta F, Bonofiglio R, Paone A, Chiarinotti D, Messa PG, Teodoro C, Pedrini L, Feriani M, Greco S, Merico G, Gallieni M., STEFONI, SERGIO, Locatelli F, Zoccali C, Catucci AE, Minutolo R, De Nicola L, Grillo C, Beltrame A, Fagugli R, Catizone L, Mancini W, Di Luzio V, Brigante M, Battaglia G, Adorati Menegato M, Bonfante L, Stefoni S, Parravano M, Ronco C, Farina M, Spotti D, De Santo NG, Moriconi L, Bellinghieri G, Ricciardi B, Costanzo R, Conti M, Piazza V, Dal Canton A, Corti MM, Della Grotta F, Bonofiglio R, Paone A, Chiarinotti D, Messa PG, Teodoro C, Pedrini L, Feriani M, Greco S, Merico G, and Gallieni M

Published
2007

112. Diagnosi e trattamento dell'anemia nell'IRC in terapia conservativa. Dati preliminari dello studio SIN-SIR (Studio italiano Indicatori di Risultato multipli - Epidemiologia dell'IRC in Italia) della Società Italiana di Nefrologia

Author

Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, Bottalico D., STEFONI, SERGIO, Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Stefoni S, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, and Bottalico D.

Subjects
ANEMIA, TERAPIA CONSERVATIVA, INSUFFICIENZA RENALE CRONICA
Published
2006

113. Studio SIR-SIN (Studio italiano Indicatori di Risultato multipli - Epidemiologia dell'IRC in Italia) della Societa Italiana di Nefrologia nella popolazione affetta da IRC in terapia conservativa. Dati preliminari

Author

Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, Bottalico D., STEFONI, SERGIO, Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Stefoni S, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, and Bottalico D.

Subjects
INSUFFICIENZA RENAEL CRONICA, TERAPIA CONSERVATIVA
Published
2006

114. Timing di creazione dell'accesso vascolare per emodialisi. Dati preliminari dello studio SIN-SIR (Studio italiano Indicatori di Risultato multipli - Epidemiologia dell'IRC in Italia) della Società Italiana di Nefrologia nella popolazione affetta da IRC in terapia conservativa

Author

Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, Bottalico D., STEFONI, SERGIO, Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Stefoni S, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, and Bottalico D.

Subjects
ACCESSO VASCOLARE, EMODIALISI, TERAPIA CONSERVATIVA, INSUFFICIENZA RENALE CRONICA
Published
2006

115. Chronic kidney disease (CKD) in Italy: A multicenter study. Results of a questionnaire on the clinical management of CKD stage 3-5 patients

Author

Locatelli, F., Zoccali, C., Catucci, Ae, Savica, V., Liuzzo, G., Nardo, A., Minutolo, R., Nicola, L., Ricciardi, B., Mancini, W., Balducci, A., Costanzo, R., Di Luca, M., Ariano, R., Di Luzio, V., Brigante, M., Battaglia, G., Menegato, Ma, Di Landro, D., Altieri, P., Auricchio, Mr, Lodeserto, C., Stefoni, S., D Angelo, A., Imbasciati, E., Spotti, D., Cristofaro, V., Rapisarda, F., Piazza, V., Claudio Ronco, De Santo NG, Stella, A., Dani, L., Dal Canton, A., Corti, Mm, Teodoro, C., Della Grotta, F., Grillo, C., Catizone, L., Cabibbe, M., Bonofiglio, R., Capistrano, M., Paone, A., Buongiorno, E., Feliciani, Al, Chiarinotti, D., Rotolo, U., Feriani, M., Garibotto, G., Gallieni, M., Merico, G., Del Santo, A., Bottalico, D., Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Adorati Menegato M, Di Landro D, Altieri P, Auricchio MR, Lodeserto C, Stefoni S, D'Angelo A, Imbasciati E, Spotti D, De Cristofaro V, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Dani L, Dal Canton A, Corti MM, Teodoro C, Della Grotta F, Grillo C, Catizone L, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Rotolo U, Feriani M, Garibotto G, Gallieni M, Merico G, Del Santo A, and Bottalico D

Published
2006

116. Modalità di stima del filtrato glomerulare (FG) e inizio della dialisi. Dati preliminari dello studio SIR-SIN (Studio italiano Indicatori di Risultato multipli - Epidemiologia dell'IRC in Italia) della Societa Italiana di Nefrologia nella popolazione affetta da IRC in terapia conservativa

Author

Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, Bottalico D., STEFONI, SERGIO, Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Stefoni S, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, and Bottalico D

Subjects
FILTRATO GLOMERULARE, DIALISI, INSUFFICIENZA RENALE CRONICA
Published
2006

119. Low field magnetotransport in strained Si/SiGe cavities RID C-7045-2008

Author

Scappucci G, DI GASPARE, LUCIANA, Evangelisti F, Giovine E, Notargiacomo A, Leoni R, Piazza V, Pingue P, Beltram F., Scappucci, G, DI GASPARE, Luciana, Evangelisti, F, Giovine, E, Notargiacomo, A, Leoni, R, Piazza, V, Pingue, P, and Beltram, F.

Subjects
Condensed Matter::Materials Science, Condensed Matter::Strongly Correlated Electrons, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Computer Science::Other
Abstract

Low field magnetotransport revealing signatures of ballistic transport effects in strained Si/SiGe cavities is investigated. We fabricated strained Si/SiGe cavities by confining a high mobility Si/SiGe two-dimensional electron gas in a bended nanowire geometry defined by electron-beam lithography and reactive ion etching. The main features observed in the low temperature magnetoresistance curves are the presence of a zero-field magnetoresistance peak and of an oscillatory structure at low fields. By adopting a simple geometrical model we explain the oscillatory structure in terms of electron magnetic focusing. A detailed examination of the zero-field peak line shape clearly shows deviations from the predictions of ballistic weak localization theory.

Published
2005

120. Recurrent ETNK1 mutations in atypical chronic myeloid leukemia

Author

GAMBACORTI PASSERINI, C, Donadoni, C, Parmiani, A, Pirola, A, Redaelli, S, Signore, G, Piazza, V, Malcovati, L, Fontana, D, Spinelli, R, Magistroni, V, Gaipa, G, Peronaci, M, Morotti, A, Panuzzo, C, Saglio, G, Usala, E, Kim, D, Rea, D, Zervakis, K, Viniou, N, Symeonidis, A, Becker, H, Boultwood, J, Campiotti, L, Carrabba, M, Elli, E, Bignell, G, Papaemmanuil, E, Campbell, P, Cazzola, M, Piazza, R, GAMBACORTI PASSERINI, CARLO, DONADONI, CARLA, PIROLA, ALESSANDRA, REDAELLI, SARA, FONTANA, DILETTA, SPINELLI, ROBERTA, MAGISTRONI, VERA, PERONACI, MARCO, PIAZZA, ROCCO GIOVANNI, GAMBACORTI PASSERINI, C, Donadoni, C, Parmiani, A, Pirola, A, Redaelli, S, Signore, G, Piazza, V, Malcovati, L, Fontana, D, Spinelli, R, Magistroni, V, Gaipa, G, Peronaci, M, Morotti, A, Panuzzo, C, Saglio, G, Usala, E, Kim, D, Rea, D, Zervakis, K, Viniou, N, Symeonidis, A, Becker, H, Boultwood, J, Campiotti, L, Carrabba, M, Elli, E, Bignell, G, Papaemmanuil, E, Campbell, P, Cazzola, M, Piazza, R, GAMBACORTI PASSERINI, CARLO, DONADONI, CARLA, PIROLA, ALESSANDRA, REDAELLI, SARA, FONTANA, DILETTA, SPINELLI, ROBERTA, MAGISTRONI, VERA, PERONACI, MARCO, and PIAZZA, ROCCO GIOVANNI

Abstract

Despite the recent identification of recurrent SETBP1 mutations in atypical chronic myeloid leukemia (aCML), a complete description of the somatic lesions responsible for the onset of this disorder is still lacking. To find additional somatic abnormalities in aCML, we performed whole-exome sequencing on 15 aCML cases. In 2 cases (13.3%), we identified somatic missense mutations in the ETNK1 gene. Targeted resequencing on 515 hematological clonal disorders revealed the presence of ETNK1 variants in 6 (8.8%) of 68 aCML and 2 (2.6%) of 77 chronic myelomonocytic leukemia samples. These mutations clustered in a small region of the kinase domain, encoding for H243Y and N244S (1/8 H243Y; 7/8 N244S). They were all heterozygous and present in the dominant clone. The intracellular phosphoethanolamine/phosphocholine ratio was, on average, 5.2-fold lower in ETNK1-mutated samples ( P < .05). Similar results were obtained using myeloid TF1 cells transduced with ETNK1 wild type, ETNK1-N244S, and ETNK1-H243Y, where the intracellular phosphoethanolamine/phosphocholine ratio was significantly lower in ETNK1-N244S (0.76 ± 0.07) and ETNK1-H243Y (0.37 ± 0.02) than in ETNK1-WT (1.37 ± 0.32; P = .01 and P = .0008, respectively), suggesting that ETNK1 mutations may inhibit the catalytic activity of the enzyme. In summary, our study shows for the first time the evidence of recurrent somatic ETNK1 mutations in the context of myeloproliferative/myelodysplastic disorders.

Published
2015

121. Interface nano-confined acoustic waves in polymeric surface phononic crystals

Author

Travagliati, M, Nardi, D, Giannetti, Claudio, Gusev, V, Pingue, P, Piazza, V, Ferrini, Gabriele, Banfi, Francesco, Giannetti, Claudio (ORCID:0000-0003-2664-9492), Ferrini, Gabriele (ORCID:0000-0002-5062-9099), Banfi, Francesco (ORCID:0000-0002-7465-8417), Travagliati, M, Nardi, D, Giannetti, Claudio, Gusev, V, Pingue, P, Piazza, V, Ferrini, Gabriele, Banfi, Francesco, Giannetti, Claudio (ORCID:0000-0003-2664-9492), Ferrini, Gabriele (ORCID:0000-0002-5062-9099), and Banfi, Francesco (ORCID:0000-0002-7465-8417)

Abstract

The impulsive acoustic dynamics of soft polymeric surface phononic crystals is investigated here in the hypersonic frequency range by near-IR time resolved optical diffraction. The acoustic response is analysed by means of wavelet spectral methods and finite element modeling. An unprecedented class of acoustic modes propagating within the polymer surface phononic crystal and confined within 100 nm of the nano-patterned interface is revealed. The present finding opens the path to an alternative paradigm for characterizing the mechanical properties of soft polymers at interfaces and for sensing schemes exploiting polymers as embedding materials.

Published
2015

128. Terpenes from the Red Alga Sphaerococcus coronopifolius Inhibit the Settlement of Barnacles

Author

Piazza, V. Roussis, V. Garaventa, F. Greco, G. Smyrniotopoulos, V. Vagias, C. Faimali, M.

Abstract

In this study, we screened eight terpenes isolated from the organic extract of Sphaerococcus coronopifolius for their antifouling activity in order to find possible new sources of non-toxic or less toxic bioactive antifoulants. The anti-settlement activity (EC 50) and the degree of toxicity (LC 50) of S. coronopifolius metabolites was evaluated using larvae of the cirriped crustacean Amphibalanus (Balanus) amphitrite (cyprids and nauplii) as model organism. For five of eight tested metabolites EC 50 was lower than 5 mg/L. The most promising results were observed for bromosphaerol (3), which expressed an EC 50 value of 0.23 mg/L, in combination with low toxicity levels (LC 50 > 100 mg/L). The therapeutic ratio-an index used to estimate whether settlement inhibition is due to toxicity or other mechanisms-is also calculated and discussed. © 2010 Springer Science+Business Media, LLC.

Published
2011

135. A multi-endpoints bioassay with Amphibalanus amphitrite larvae as a tool in ecotoxicology studies

Author

Piazza V., Garaventa F., Corrà C., and Faimali M.

Subjects
fungi
Abstract

In recent years massive efforts have been directed to identify ecologically relevant invertebrate toxicity testing models. The crustacean Amphibalanus amphitrite represent a valid model for ecotoxicology studies, as it is widely distributed, ecologically relevant and its larvae can be easily obtained and reared in laboratory. The UNICHIM standardization process of the acute toxicity assay with larvae (II stage nauplii) of A. amphitrite has recently been concluded. Aim of this work is to show the possibility of obtaining three distinct end-points (acute and sub-lethal), characterized by different sensitivity levels, by the use of the same model organism and the preparation of just one bioassay. Marine sediments (elutriates and whole sediment) were used as an example of environmental sample.

Published
2010

136. Patient preferences in the choice of anti-TNF therapies in heumatoid arthritis. Results from a questionnaire survey (RIVIERA study)

Author

Scarpato, S., Antivalle, M., Favalli, E. G., Nacci, F., Frigelli, S., Bartoli, F., Bazzichi, L., Minisola, G., Matucci Cerinic, M., Salvarani, Carlo, Altucci, P, Bombardieri, S, Battaglia, E, Ferri, Clodoveo, Pozzi, Mr, Afeltra, A, Bersi, M, Tartarelli, G, Montecucco, Cm, Altomare, E, Bambara, Lm, Bucci, R, Colombelli, Pl, Corsaro, S, Rinaldi, F, Sinigaglia, L, Trotta, F, Carrabba, M, Migliore, A, Bianchi, G, Grassi, W, Rocchetta, Pa, Altomonte, L, Coaccioli, S, Danieli Armando, G, Perpignano, G, Broggini, M, Morassi, P, Peronato, G, Canesi, B, Delsante, G, Di Giuseppe, P, Di Rosa SO, Gorla, R, Malavolta, N, Solinas, F, Todesco, S, Varcasia, G, Versace, F, Sabadini, L, Del Giacco, S, Marasini, B, Bagnato, G, Gerli, R, Modena, V, and Di Piazza, V.

Subjects
rheumatoid arthritis, Adult, Male, medicine.medical_specialty, Adolescent, Rheumatoid arthritis, Anti-TNF therapy, Decision making, Patient empowerment, Arthritis, Self Administration, Infusions, Subcutaneous, Choice Behavior, Arthritis, Rheumatoid, Route of administration, Young Adult, Rheumatology, Internal medicine, medicine, Humans, Pharmacology (medical), Young adult, RIVIERA study, anti-TNF therapies, Infusions, Intravenous, Aged, Response rate (survey), Aged, 80 and over, business.industry, Tumor Necrosis Factor-alpha, Questionnaire, Patient Preference, Middle Aged, medicine.disease, Italy, Antirheumatic Agents, Physical therapy, Female, Analysis of variance, business, Epidemiologic Methods
Abstract

Objective. To identify the determinants of anti-TNF-naive patients’ preferences for the route of administration of anti-TNF agents. Methods. The study was carried out in 50 Italian rheumatology centres (802 patients). All patients completed a 31-item questionnaire addressing their perceptions of current treatment and the preferences for treatment with anti-TNF agents. Statistical methods included analysis of variance (ANOVA), t-test and chi-square test. Results. The response rate to the questionnaire was 97.6%. At the time of the survey, 310 (39.9%) patients were dissatisfied with current treatments, owing to inefficacy, side effects and inconvenience of administration. The i.v. and s.c. routes of administration were preferred by 50.2 and 49.8%, respectively. No significant difference was found in patients by gender, age, RA duration or number of drugs used. Reasons for the choice of i.v. administration were the safety of treatment at the hospital and the reassuring effect of physician presence. The s.c. administration was chosen for the convenience of treatment and in particular for home treatment. Patients dissatisfied with current therapy due to side effects preferred s.c. administration (P ¼ 0.029), whereas patients choosing the i.v. route had slightly higher scores on ‘today pain’ (P ¼ 0.047) and ‘articular pain’ (P ¼ 0.023) of the Rheumatoid Arthritis Disease Activity Index (RADAI). Conclusions. Both i.v. and s.c. treatments were well accepted by patients. However, treatment choice has to be discussed with patients, as individual preference seems to be determined by personal attitudes towards safety and convenience, by past experience and by the perception of current disease status.

Published
2010

143. Evidence of ETNK1 Somatic Variants in Atypical Chronic Myeloid Leukemia

Author

Donadoni, C, Piazza, R, Fontana, D, Parmiani, A, Pirola, A, Redaelli, S, Signore, G, Piazza, V, Malcovati, L, Spinelli, R, Magistroni, V, Gaipa, G, Peronaci, M, Morotti, A, Panuzzo, C, Saglio, G, Elli, E, Usala, E, Kim, D, Rea, D, Zervakis, K, Viniou, N, Symeonidis, A, Becker, H, Boultwood, J, Campiotti, L, Carrabba, M, Bignell, G, Papaemmanuil, E, Campbell, P, Cazzola, M, GAMBACORTI PASSERINI, C, DONADONI, CARLA, PIAZZA, ROCCO GIOVANNI, FONTANA, DILETTA, PIROLA, ALESSANDRA, REDAELLI, SARA, SPINELLI, ROBERTA, MAGISTRONI, VERA, GAIPA, GIUSEPPE, PERONACI, MARCO, ELLI, ELENA MARIA, GAMBACORTI PASSERINI, CARLO, Donadoni, C, Piazza, R, Fontana, D, Parmiani, A, Pirola, A, Redaelli, S, Signore, G, Piazza, V, Malcovati, L, Spinelli, R, Magistroni, V, Gaipa, G, Peronaci, M, Morotti, A, Panuzzo, C, Saglio, G, Elli, E, Usala, E, Kim, D, Rea, D, Zervakis, K, Viniou, N, Symeonidis, A, Becker, H, Boultwood, J, Campiotti, L, Carrabba, M, Bignell, G, Papaemmanuil, E, Campbell, P, Cazzola, M, GAMBACORTI PASSERINI, C, DONADONI, CARLA, PIAZZA, ROCCO GIOVANNI, FONTANA, DILETTA, PIROLA, ALESSANDRA, REDAELLI, SARA, SPINELLI, ROBERTA, MAGISTRONI, VERA, GAIPA, GIUSEPPE, PERONACI, MARCO, ELLI, ELENA MARIA, and GAMBACORTI PASSERINI, CARLO

Published
2014

150. Clinical policies on the management of chronic kidney disease patients in Italy

Author

Locatelli, F, Zoccali, C, SIR SIN STUDY INVESTIGATORS, COLLABORATORS ACCIARRI, P, Menegato, Ma, Ancarani, E, Andreucci, V, Antonelli, A, Auricchio, Mr, Balducci, A, Bassi, A, Battaglia, G, Bellingheri, G, Beltrame, A, Biagini, M, Bonfante, L, Bonofiglio, R, Bonomini, M, Borghi, M, Brigante, M, Buccianti, G, Buongiorno, E, Cabibbe, M, Cancarini, Giovanni, Capistrano, M, Cappelli, G, Capuano, M, Cascone, C, Catizone, L, Catucci, Ae, Cavatorta, F, Chiarinotti, D, Cicchetti, T, Concas, G, Concetti, M, Conte, F, Conti, M, Coratelli, P, Corti, Mm, Costanzo, R, Dal, Canton, A, D'Apice, L, David, S, DE CRISTOFARO, V, Deferrari, G, DELLA GROTTA, F, Nicola, L, DE SANTO NG, DE SIMONE, W, DI DANIELE, N, DI GIULIO, S, DI LANDRO, D, Luzio, V, DI MAGGIO, A, Fagugli, R, Farina, M, Feriani, M, Gallieni, M, Gambaro, G, Giordano, R, Greco, S, Grillo, C, Huber, W, Liuzzo, G, Lombardi, L, Lopez, T, Malberti, F, Mancini, W, Manenti, F, Manisco, G, Marrocco, A, Matocci, G, Merico, G, Messa, P, Minutolo, R, Monardo, P, Moriconi, L, Murrone, P, Nardo, A, Naso, A, Nobile, R, Panarello, G, Paone, A, Parravano, M, Pedrini, L, Piazza, V, Pistis, R, Procida, M, Quarello, F, Rapisarda, F, Ricciardi, B, Rindi, P, Ronco, C, Rotolo, U, Russo, G, Saraniti, A, Sasdelli, M, Savica, V, Scanziani, R, Sidoti, A, Spotti, D, Stalteri, A, Stefoni, S, Stella, A, Strippoli, P, Teatini, U, Teodoro, C, Tozzo, C, Triolo, G, and Zoccali, C.

Subjects
Chrinic kidney disease, anemia
Published
2008

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