101. Rate of malignancy in MRI-detected probably benign (BI-RADS 3) lesions.
- Author
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Spick C, Szolar DH, Baltzer PA, Tillich M, Reittner P, Preidler KW, Pinker-Domenig K, and Helbich TH
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Austria epidemiology, Female, Humans, Incidence, Middle Aged, Reproducibility of Results, Risk Assessment, Sensitivity and Specificity, Young Adult, Breast Neoplasms epidemiology, Breast Neoplasms pathology, Early Detection of Cancer statistics & numerical data, Magnetic Resonance Imaging statistics & numerical data
- Abstract
Objective: The purpose of this study was to evaluate the malignancy rate in MRI-detected probably benign (BI-RADS 3) lesions in women without a history of breast cancer., Materials and Methods: In this study, 1265 patients underwent breast MRI during a 7-year period. One hundred and eight (8.5%) patients with a nonpalpable breast lesion classified as BI-RADS 3 at MRI and with a needle biopsy or adequate follow-up of at least 24 months were included. Statistical analysis included calculation of the negative predictive value with its 95% CI., Results: Of 108 lesions, 107 (99.1%) were correctly assessed as probably benign, resulting in a negative predictive value of 99.1% (95% CI, 94.99-99.98%). Histopathology was requested by the patient or referring physician in 44 patients. Of these, 43 (39.8%) lesions were classified as benign and one (0.9%) as malignant. There were no changes evident in any of the remaining 64 (59.2%) lesions during follow-up (range, 2-9 years)., Conclusion: In MRI-detected probably benign (BI-RADS 3) lesions, the malignancy rate is low and within the accepted cancer rate for mammographically or sonographically detected BI-RADS 3 lesions. Short-term follow-up MRI at intervals of 6, 12, and 24 months in MRI BI-RADS 3 lesions remains a strong tool with which to detect suspicious lesions. Interval changes in size, morphology, or enhancement are regarded as indicative of malignancy.
- Published
- 2014
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