Search

Your search keyword '"Plaja A"' showing total 2,174 results
Start Over Author "Plaja A"
Sorry, I don't understand your search. ×
2,174 results on '"Plaja A"'

103. Prognostic Role of Neutrophil, Monocyte and Platelet to Lymphocyte Ratios in Advanced Ovarian Cancer According to the Time of Debulking Surgery

Author

Plaja, Andrea, primary, Teruel, Iris, additional, Ochoa-de-Olza, Maria, additional, Cucurull, Marc, additional, Arroyo, Álvaro Javier, additional, Pardo, Beatriz, additional, Ortiz, Irene, additional, Gil-Martin, Marta, additional, Piulats, Josep María, additional, Pla, Helena, additional, Fina, Claudia, additional, Carbó, Anna, additional, Barretina-Ginesta, Maria-Pilar, additional, Martínez-Román, Sergio, additional, Carballas, Elvira, additional, González, Andrea, additional, Esteve, Anna, additional, and Romeo, Margarita, additional

Published
2023
Full Text
View/download PDF

107. Surprise in Highly Correlated Two-Electron System: Extended Secondary Plateau in X-ray High Harmonic Generation from Helium Due to Double Electron Recombination

Author

Wang, Siyang, primary, Yan, Jieyu, additional, De las Heras, Alba, additional, Song, Sirius, additional, Prodanov, Aleksander, additional, Wu, Zhihan, additional, Hernández-García, Carlos, additional, Plaja, Luis, additional, Popmintchev, Dimitar, additional, and Popmintchev, Tenio, additional

Published
2023
Full Text
View/download PDF

110. Hypoxia: The Cornerstone of Glioblastoma

Author

Marta Domènech, Ainhoa Hernández, Andrea Plaja, Eva Martínez-Balibrea, and Carmen Balañà

Subjects
glioblastoma, hypoxia, HIF-1, HIF-1 inhibitors, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Glioblastoma is the most aggressive form of brain tumor in adults and is characterized by the presence of hypervascularization and necrosis, both caused by a hypoxic microenvironment. In this review, we highlight that hypoxia-induced factor 1 (HIF-1), the main factor activated by hypoxia, is an important driver of tumor progression in GB patients. HIF-1α is a transcription factor regulated by the presence or absence of O2. The expression of HIF-1 has been related to high-grade gliomas and aggressive tumor behavior. HIF-1 promotes tumor progression via the activation of angiogenesis, immunosuppression, and metabolic reprogramming, promoting cell invasion and survival. Moreover, in GB, HIF-1 is not solely modulated by oxygen but also by oncogenic signaling pathways, such as MAPK/ERK, p53, and PI3K/PTEN. Therefore, the inhibition of the hypoxia pathway could represent an important treatment alternative in a disease with very few therapy options. Here, we review the roles of HIF-1 in GB progression and the inhibitors that have been studied thus far, with the aim of shedding light on this devastating disease.

Published
2021
Full Text
View/download PDF

113. Lectura, educación y bibliotecas: ideas para crear buenos lectores

Author

Gómez-Hernández, José-Antonio, Calvo-Alonso-Cortés, Blanca, Benito-Morales, Félix, Salaberria, Ramón, Guillermo-Díaz, María, Palacios-Rozalén, Alonso, Díaz-Plaja, Aurora, Martín-Nebrás, Federico, Cobos, Laura, Álvarez, Melquíades, Gómez-Hernández, José-Antonio, Gómez-Hernández, José-Antonio, Calvo-Alonso-Cortés, Blanca, Benito-Morales, Félix, Salaberria, Ramón, Guillermo-Díaz, María, Palacios-Rozalén, Alonso, Díaz-Plaja, Aurora, Martín-Nebrás, Federico, Cobos, Laura, and Álvarez, Melquíades

Subjects
CC. User categories: children, young people, social groups., CE. Literacy., DE. School libraries.
Abstract

Some strategies of reading promotion are described and explained

Published
1994

114. Bright Isolated Attosecond Soft X-Ray Pulses

Author

Chen, M.-C., Mancuso, C., Hernández-García, C., Dollar, F., Galloway, B., Popmintchev, D., Langdon, B., Auger, A., Huang, P.-C., Walker, B.C., Plaja, L., Jaron-Becker, A., Becker, A., Murnane, M. M., Kapteyn, H. C., Popmintchev, T., Yamanouchi, Kaoru, editor, Cundiff, Steven, editor, de Vivie-Riedle, Regina, editor, Kuwata-Gonokami, Makoto, editor, and DiMauro, Louis, editor

Published
2015
Full Text
View/download PDF

115. Polarization control of isolated high-harmonic pulses

Author

Huang, Pei-Chi, Hernández-García, Carlos, Huang, Jen-Ting, Huang, Po-Yao, Lu, Chih-Hsuan, Rego, Laura, Hickstein, Daniel D., Ellis, Jennifer L., Jaron-Becker, Agnieszka, Becker, Andreas, Yang, Shang-Da, Durfee, Charles G., Plaja, Luis, Kapteyn, Henry C., Murnane, Margaret M., Kung, A. H., and Chen, Ming-Chang

Published
2018
Full Text
View/download PDF

116. Persistence of long-term COVID-19 sequelae in patients with cancer: An analysis from the OnCovid registry

Author

Alessio Cortellini, Ramon Salazar, Alessandra Gennari, Juan Aguilar-Company, Mark Bower, Alexia Bertuzzi, Joan Brunet, Matteo Lambertini, Clara Maluquer, Paolo Pedrazzoli, Alvin JX. Lee, MCarmen Carmona-García, Thomas Newsom-Davis, Mieke Van Hemelrijck, Andrea Plaja, Alberto Zambelli, Carlo Tondini, Daniele Generali, Rossella Bertulli, Nikolaos Diamantis, Uma Mukherjee, Gianpiero Rizzo, Tamara Yu, Federica Zoratto, Riccardo Bruna, Anna Sureda, Clara Martinez-Vila, Luca Cantini, Francesca Mazzoni, Federica Grosso, Alessandro Parisi, Maristella Saponara, Aleix Prat, David J. Pinato, and Pulmonary Medicine

Subjects
Cancer Research, COVID-19 Testing, Post-Acute COVID-19 Syndrome, SDG 3 - Good Health and Well-being, Oncology, Neoplasms, Disease Progression, COVID-19, Humans, Registries
Abstract

Introduction: A significant proportion of patients with cancer who recover from Coronavirus Disease 2019 (COVID-19) may experience COVID-19 sequelae in the early post-infection phase, which negatively affect their continuity of care and oncological outcome. The long-term prevalence and clinical impact of the post-COVID-19 syndrome in patients with cancer are largely unknown. Methods: In this study, we describe the time course of COVID-19 sequelae in patients with non-advanced cancers enrolled in the OnCovid registry. Results: Overall, 186 patients were included, with a median observation period of 9.9 months (95%CI:8,8–11.3) post-COVID-19 resolution. After a median interval of 2.3 months post-COVID-19 (interquartile range: 1.4–3.7), 31 patients (16.6%) reported ≥1 sequelae, including respiratory complications (14, 7.6%), fatigue (13, 7.1%), neuro-cognitive sequelae (7, 3.8%). The vast majority of the patients were not vaccinated prior to COVID-19. COVID-19-related sequelae persisted in 9.8% and 8% of patients 6 and 12 months after COVID-19 resolution. Persistence of sequelae at first oncological follow-up was associated with history of complicated COVID-19 (45.2% vs 24.8%, p = 0.0223), irrespective of oncological features at COVID-19 diagnosis. Conclusion: This study confirms for the first time that, in a largely unvaccinated population, post-COVID-19 syndrome can affect a significant proportion of patients with non-advanced cancer who recovered from the acute illness. COVID-19 sequelae may persist up to 12 months in some patients, highlighting the need for dedicated prevention and supportive strategies.

Published
2022

117. Pandemic Phase-Adjusted Analysis of COVID-19 Outcomes Reveals Reduced Intrinsic Vulnerability and Substantial Vaccine Protection From Severe Acute Respiratory Syndrome Coronavirus 2 in Patients With Breast Cancer

Author

Tagliamento, Marco, primary, Gennari, Alessandra, additional, Lambertini, Matteo, additional, Salazar, Ramon, additional, Harbeck, Nadia, additional, Del Mastro, Lucia, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Sharkey, Rachel, additional, Dalla Pria, Alessia, additional, Plaja, Andrea, additional, Jackson, Amanda, additional, Handford, Jasmine, additional, Sita-Lumsden, Ailsa, additional, Martinez-Vila, Clara, additional, Matas, Marta, additional, Miguel Rodriguez, Ana, additional, Vincenzi, Bruno, additional, Tonini, Giuseppe, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Pedrazzoli, Paolo, additional, D'Avanzo, Francesca, additional, Biello, Federica, additional, Sinclair, Alasdair, additional, Lee, Alvin J.X., additional, Rossi, Sabrina, additional, Rizzo, Gianpiero, additional, Mirallas, Oriol, additional, Pimentel, Isabel, additional, Iglesias, Maria, additional, Sanchez de Torre, Ana, additional, Guida, Annalisa, additional, Berardi, Rossana, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Filetti, Marco, additional, Mazzoni, Francesca, additional, Mukherjee, Uma, additional, Diamantis, Nikolaos, additional, Parisi, Alessandro, additional, Aujayeb, Avinash, additional, Prat, Aleix, additional, Libertini, Michela, additional, Grisanti, Salvatore, additional, Rossi, Maura, additional, Zoratto, Federica, additional, Generali, Daniele, additional, Saura, Cristina, additional, Lyman, Gary H., additional, Kuderer, Nicole M., additional, Pinato, David J., additional, and Cortellini, Alessio, additional

Published
2023
Full Text
View/download PDF

118. SARS-CoV-2 omicron (B.1.1.529)-related COVID-19 sequelae in vaccinated and unvaccinated patients with cancer: results from the OnCovid registry

Author

Cortellini, Alessio, primary, Tabernero, Josep, additional, Mukherjee, Uma, additional, Salazar, Ramon, additional, Sureda, Anna, additional, Maluquer, Clara, additional, Ferrante, Daniela, additional, Bower, Mark, additional, Sharkey, Rachel, additional, Mirallas, Oriol, additional, Plaja, Andrea, additional, Cucurull, Marc, additional, Mesia, Ricard, additional, Dalla Pria, Alessia, additional, Newsom-Davis, Thomas, additional, Van Hemelrijck, Mieke, additional, Sita-Lumsden, Ailsa, additional, Apthorp, Eleanor, additional, Vincenzi, Bruno, additional, Di Fazio, Giuseppina Rita, additional, Tonini, Giuseppe, additional, Pantano, Francesco, additional, Bertuzzi, Alexia, additional, Rossi, Sabrina, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Pedrazzoli, Paolo, additional, Biello, Federica, additional, D'Avanzo, Francesca, additional, Lee, Alvin J X, additional, Shawe-Taylor, Marianne, additional, Rogers, Lucy, additional, Murphy, Cian, additional, Cooper, Lee, additional, Andaleeb, Ramis, additional, Khalique, Saira, additional, Bawany, Samira, additional, Ahmed, Sarah, additional, Carmona-García, M Carmen, additional, Fort-Culillas, Roser, additional, Liñan, Raquel, additional, Zoratto, Federica, additional, Rizzo, Gianpiero, additional, Perachino, Marta, additional, Doonga, Kris, additional, Gaidano, Gianluca, additional, Bruna, Riccardo, additional, Patriarca, Andrea, additional, Martinez-Vila, Clara, additional, Pérez Criado, Ignacio, additional, Giusti, Raffaele, additional, Mazzoni, Francesca, additional, Antonuzzo, Lorenzo, additional, Santoro, Armando, additional, Parisi, Alessandro, additional, Queirolo, Paola, additional, Aujayeb, Avinash, additional, Rimassa, Lorenza, additional, Diamantis, Nikolaos, additional, Bertulli, Rossella, additional, Fulgenzi, Claudia A M, additional, D'Alessio, Antonio, additional, Ruiz-Camps, Isabel, additional, Saoudi-Gonzalez, Nadia, additional, Garcia Illescas, David, additional, Medina, Irene, additional, Fox, Laura, additional, Gennari, Alessandra, additional, Aguilar-Company, Juan, additional, Pinato, David J, additional, Evans, Joanne S, additional, Swallow, Judith, additional, Hanbury, Georgina, additional, Chung, Chris, additional, Patel, Meera, additional, Dettorre, Gino, additional, Belessiotis, Katherine, additional, Saorise, Dolly, additional, Jones, Eleanor, additional, Moss, Charlotte, additional, Russell, Beth, additional, Townsend, Sarah, additional, Jackson, Amanda, additional, Loizidou, Angela, additional, Piccart, Martine, additional, Pommeret, Fanny, additional, Colomba-Blameble, Emeline, additional, Prat, Aleix, additional, Cruz, Claudia A, additional, Reyes, Roxana, additional, Segui, Elia, additional, Marco-Hernández, Javier, additional, Viladot, Margarita, additional, Harbeck, Nadia, additional, Wuerstlein, Rachel, additional, Henze, Franziska, additional, Mahner, Sven, additional, Felip, Eudald, additional, Scotti, Lorenza, additional, Marrari, Andrea, additional, Grosso, Federica, additional, Fusco, Vittorio, additional, Delfanti, Sara, additional, Rossi, Maura, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Libertini, Michela, additional, Provenzano, Salvatore, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Baggi, Alice, additional, Tovazzi, Valeria, additional, Ficorella, Corrado, additional, Porzio, Giampiero, additional, Saponara, Maristella, additional, Filetti, Marco, additional, Tucci, Marco, additional, Berardi, Rossana, additional, Cantini, Luca, additional, Paoloni, Francesco, additional, Guida, Annalisa, additional, Bracarda, Sergio, additional, Iglesias, Maria, additional, Sanchez de Torre, Ana, additional, and Tagliamento, Marco, additional

Published
2023
Full Text
View/download PDF

119. Subcutaneous anti-COVID-19 hyperimmune immunoglobulin for prevention of disease in asymptomatic individuals with SARS-CoV-2 infection: a double-blind, placebo-controlled, randomised clinical trial

Author

Alemany, Andrea, primary, Millat-Martinez, Pere, additional, Corbacho-Monné, Marc, additional, Suñer, Clara, additional, Galvan-Casas, Cristina, additional, Carrera, Caty, additional, Ouchi, Dan, additional, Prat, Núria, additional, Ara, Jordi, additional, Nadal, Nuria, additional, Riel, Ricard, additional, Funollet, Blanca, additional, Ojeda-Ciurana, Carmen, additional, Balague, Lluis Esteve, additional, Salvador-González, Betlem, additional, Arcarons, Anna Forcada, additional, Vidal-Alaball, Josep, additional, Del Cura-González, María Isabel, additional, Barrientos, Ricardo Rodríguez, additional, Ramos-Blanes, Rafel, additional, Bou, Alberto Alum, additional, Mondou, Elsa, additional, Torres, Mireia, additional, Campins, Neus, additional, Sanz, Ana, additional, Tang, Yonggiang, additional, Rodriguez-Arias, Miquel Àngel, additional, Bassat, Quique, additional, Clotet, Bonaventura, additional, Mitjà, Oriol, additional, Aguilar-Uroz, Adrià, additional, Rosell-García-Ufano, Adrià, additional, Escudero Planas, Adrián, additional, Baelo, Aida, additional, Villahoz Martín, Ainhoa, additional, Moreno López, Alberto, additional, Roldan Ruiz, Alberto, additional, Santana Briongos, Alberto, additional, Tejera Bodas, Alberto, additional, Alonso-Vallés, Alejandro, additional, Fletes-Pérez, Alejandro, additional, Hueso-Mor, Alejandro, additional, Boluda, Alex, additional, Santamaria, Alex, additional, Diestro, Alicia Santos, additional, Revuelta-Álvarez, Almudena, additional, Moreno Moreno, Álvaro, additional, Ortega de Felipe, Ana, additional, Chen-Ye, Ana, additional, Blázquez Valerón, Ana, additional, Rodríguez Pérez, Ana Belén, additional, Tristán Morgalo, Ana Laura, additional, Fernández-Allende, Ana Luisa, additional, Bagán-Trejo, Andrea, additional, Fernández Juan, Andrés, additional, Zalve-Cano, Ángel, additional, Mateo-Martínez, Anna, additional, Galván, Antonio Valero, additional, Egidos-Plaja, Antonio, additional, Jorge, Ariadna, additional, Fraile Torres, Arturo, additional, Pareja Leal, Azahara Maria, additional, Viader Castro, Bárbara, additional, Fernandez Beato, Barbara, additional, Naveira Menchen, Barbara, additional, Martin Poyatos, Beatriz, additional, García-Martínez, Beatriz, additional, Rodrigo Testillano, Belén, additional, Blanco Tejedor, Belen, additional, López Pérez, Blanca, additional, Mencía Hernanz, Blanca, additional, González-Beiras, Camila, additional, Batres, Carlos, additional, Nuñez Garcia, Carmen, additional, Merino-Rodríguez, Carmen, additional, Rodríguez-Gilabert, Carolina, additional, Bonilla Penedo, Celia, additional, Casado Gomez, Christian, additional, Gonzalez Perez, Claudia, additional, Galindo-Tomás, Claudia, additional, Peral Bolaños, Cristina, additional, Blanco-Montes, Cristina, additional, Lupu-Yakovleva, Cristina, additional, Lopez Ruiz, Cristina, additional, Perez Mayoral, Cristina, additional, Fornes, Cristina, additional, Garcia Corrochano, Cristobal, additional, Gallardo Álvarez, Daniel, additional, Navarro Sanz, Daniel, additional, Sanz Barrio, David, additional, Ramet Meseguer, Debora, additional, Vera-Jurado, Edna Margarita, additional, Perez Costa, Eduardo, additional, Bustillos-Sebastian, Eilen Junet, additional, Palomar Casado, Elena, additional, Guerrero, Elena Dorrego, additional, Medina Mateos, Elena, additional, Aragón Gaspar, Elisa Rebeca, additional, Herrero-Vila, Elisabeth, additional, Paez Herrera, Enriqueta, additional, Rojas Powel, Esmeralda, additional, Robres Medialdea, Esther, additional, Vall-Ribalta, Esther, additional, Lopez Perez, Eva, additional, Mihaela Fer, Felicia, additional, Vazquez Ángeles, Fernanda, additional, Tirado Bejarano, Fernando, additional, Prats-Domenech, Ferran, additional, Borràs Martí, Ferran, additional, Ardila-Mejia, Gabriela, additional, Costes, Gèlia, additional, Gómez Arquero, Gema, additional, Flores Mateo, Gemma, additional, Pintos-Morell, Guillem, additional, Mira-Centelles, Helena, additional, Astola Requena, Ignacio, additional, Ortega Martin, Ignacio, additional, Leivas-Gutierrez, Iker, additional, Escribano Valenciano, Irene, additional, Muñoz Gomez, Irene, additional, Ortega, Irina, additional, Montserrat-Lloan, Isabel, additional, Gamboa, Itziar, additional, Rodríguez de Torres de Paul, Jacobo, additional, Cahís, Jordi, additional, Muñoz-Martinez, Jordi, additional, Bermejo, Jorge Iglesias, additional, Cejas López, Joselvis Virginia, additional, Canudas, Josep, additional, García Lucas, Juan Antonio, additional, Martínez-Pino, Juan Carlos, additional, Torres Martínez, Juana, additional, Pujol-Corney, Judit, additional, González Jiménez, Judith, additional, Gurí, Júlia, additional, Labella Martín, Julio, additional, Garcia-Cano, Laia, additional, Perez Plata, Lara Sonsoles, additional, Muñoz Álvaro, Laura, additional, Rodríguez Andrés, Laura, additional, Vega Ruiz, Laura, additional, Cuevas Valiente, Laura, additional, Díaz Rodríguez, Laura, additional, Puigros, Laura, additional, Cristina Piciorang, Lavinia, additional, Escudero, Leticia, additional, Figueroa Caballero, Liliana, additional, Ferrerfàbrega-Costals, Lluna, additional, Costafreda-Hernández, Lucía, additional, De-Paúl, Lucía, additional, González Fernández-Medina, Luis, additional, Moliner Prada, Ma Carmen, additional, Berriochoa Martínez de Pisón, Ma Cristina, additional, Blanco Blasco, Maria, additional, Gil Jorge, Maria, additional, Cortijo Caballero, María, additional, Ubals, Maria, additional, Gordillo, Maria, additional, Guilloto López, Maria Alicia, additional, Moreno Calvo, Maria Concepción, additional, Gil García, María del Rosario, additional, Dueñas Román, María Inmaculada, additional, Gonzalez Sanchez, Maria Josefa, additional, Nicolás Campoy, María Luisa, additional, González Velayos, Maria Luz, additional, Zori, Mario Mejías, additional, Maqueda, Mario Oliva, additional, Caño de la Cruz, Mario, additional, Palau-Morral, Mariona, additional, Martín-Muñoz, Marta, additional, Cereceda Meca, Marta, additional, Díaz Urbina, Marta, additional, VerónicaPlazas, Martha, additional, Vall-Mayans, Martí, additional, Blasco, Martí, additional, Jane Chu-Sifuentes, Mary, additional, García de Villasladad Peñaranda, Miguel, additional, Hernanz Sotoca, Miguel, additional, Iglesias Gonzalez, Miguel, additional, Labrador-Galván, Miguel Ángel, additional, Rodrigo de Vivar Azcarate, Miguel, additional, Gil-Fibla, Miquel, additional, Formentí-Pallarés, Miquel, additional, Esteve-Tugues, Mireia, additional, Juanes Perez, Miriam, additional, López Rubio, Miriam, additional, Recuero Renales, Mirian, additional, Hijós-Rullo, Mònica, additional, Lleonart-Abadia, Montserrat, additional, Finelli, Nadia, additional, Rojas-Bertier, Naiara, additional, Reyes-Calderón, Nataly, additional, Casado Larrañaga, Nerea, additional, Zurita Castrosin, Nerea Nuria, additional, Álvarez-Nieto, Noélia, additional, Leiva-Mora, Nuria, additional, Tomillo-Martín, Olga, additional, Belghazi, Omar, additional, Buscà, Oriol, additional, Mendoza Cediel, Pablo, additional, Macedo, Pablo, additional, Rodríguez Barroso, Patricia, additional, Ruiz Álvarez, Patricia, additional, López, Patricia Morales, additional, Vara de Rey, Patricia Jimenez, additional, Ginés, Paz Lozano, additional, Bris Rodriguez, Pilar, additional, Martínez-Alamillo, Pilar, additional, Salmerón Martínez, Rafa, additional, Botello Ariza, Raquel, additional, Vaquero Mena, Raquel, additional, González-Alonso, Raquel, additional, Kaczmarczyk, Raul, additional, Barnadas Vintró, Rita, additional, Hontecillas Martínez, Rodrigo, additional, Ribot-Rodríguez, Rosa, additional, Escobar-Sánchez, Rosa, additional, Montes Trinidad, Rosario Paloma, additional, Martínez Quintana, Rubén, additional, Arnay Arrogante, Ruben, additional, Berjon Sanchez, Ruben, additional, Picazo Navarro, Ruben, additional, Bastos, Rubén, additional, Martín Molinero, Samuel, additional, Israel-Benchaya, Samuel Dan, additional, Muñoz-Burguillo, Sandra, additional, Rodríguez-Salvador, Sandra, additional, Avila, Sara, additional, Corral Gayubas, Sara, additional, Nuñez Sánchez, Sergio, additional, Torres Weber, Sofía, additional, Encabo Lopez, Susana, additional, Torices Rasines, Teresa, additional, Sallas, Valentí, additional, Curto-Vicente, Verónica, additional, Gómez Hijosa, Verónica, additional, Daimiel-Pedrote, Verónica, additional, Gozalo, Verónica, additional, Barrios López, Vicente, additional, Castillo Montoya, Virginia Ivette, additional, Espinoza Pérez, Yuri, additional, CristinaBerriochoa Martínez de Pisón, María, additional, Muñoz Castillo, David, additional, Donato, Carlos, additional, and García García, Isabel, additional

Published
2023
Full Text
View/download PDF

120. Estudi d’una instal·lació geotèrmica d’un edifici públic

Author

Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Grau Saldes, Antoni, Plaja Dorca, Sergi, Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Grau Saldes, Antoni, and Plaja Dorca, Sergi

Abstract

El treball present consisteix en l’estudi i optimització d’una instal·lació geotèrmica en un edifici en plena construcció a la Zona Franca de Barcelona, més en concret parlem d’un Centre Penitenciari de Règim Obert. Per tal de complir amb el proposat en primer lloc es farà un estudi de la geotèrmia en general, i també un estudi més en concret sobre la pròpia instal·lació de la geotèrmia a l’edifici. Tanmateix, es farà un estudi de la demanda que haurà de complir la instal·lació per tal de veure si realment la compleix. Es farà una proposta de millora per tal d’implementar-la en la instal·lació i es fa un futur estudi de consum comparant la proposta inicial en comparació a la proposta de millora, a partir d’aquesta comparació es podrà obtenir l’estalvi energètic i l’estalvi econòmic gràcies a la proposta d’optimització. Es compararà la instal·lació de bombes de calor geotèrmiques amb la instal·lació de bombes de calors de ventiladors per tal de veure si realment es rentable el fet d’utilitzar la geotèrmia per tal d’abastar la climatització de l’edifici.

Published
2023

121. Elaboració de materials didàctics en llengua anglesa per fomentar l'aprenentatge d'aquesta dins el Cicle Formatiu de Grau Mitjà d'Operacions de Laboratori de la família professional de Química

Author

Universitat Politècnica de Catalunya. Institut de Ciències de l'Educació, Barreiro Taboada, Lidia, Plaja Canyet, Júlia, Universitat Politècnica de Catalunya. Institut de Ciències de l'Educació, Barreiro Taboada, Lidia, and Plaja Canyet, Júlia

Abstract

Són molts els estudis que avalen l'enfocament educatiu AICLE i els seus efectes beneficiosos sobre l'aprenentatge de les llengües estrangeres. No obstant, nombrosos experts apunten que només l'aplicació de programes ben estructurats i a llarg termini poden ajudar a obtenir bons resultats. Amb aquest treball es pretén analitzar els avantatges i inconvenients que tenen els centres educatius per aplicar l'enfocament AICLE a les programacions dels cicles formatius de la família professional de Química. Per aconseguir-ho, s'ha elaborat una enquesta dirigida al professorat de cicles formatius de Química per tal d'analitzar com s'està introduint la llengua anglesa i recollir noves propostes de millora en l'aplicació de l'enfocament AICLE a la Formació Professional. En paral·lel, s'ha elaborat material didàctic específic per al Mòdul Professional 3 de Proves Fisicoquímiques del Cicle Formatiu de Grau Mitjà d'Operacions de Laboratori i s'han inclòs activitats d'ensenyament-aprenentatge que tenen en compte la competència digital. Els resultats de l'enquesta han demostrat que gran part del professorat enquestat té un coneixement alt de la llengua anglesa però manifesten que és difícil impartir docència en anglès quan l'alumnat no té una bona base d'aquesta llengua. Han aportat propostes de millora com l'elaboració de recursos didàctics en anglès, proporcionar al professorat formació contínua en llengua anglesa i han recalcat que l'enfocament AICLE s'ha d'incorporar des de la primària.

Published
2023

122. COVID-19 severity is related to poor executive function in people with post-COVID conditions

Author

Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, Universitat Politècnica de Catalunya. IDEAI-UPC - Intelligent Data sciEnce and Artificial Intelligence Research Group, Ariza, Mar, Cano, Neus, Segura Fàbregas, Bàrbara, Adan Puig, Ana, Bargalló Alabart, Núria, Caldú Ferrús, Xavier, Campabadal Delgado, Anna, Jurado Luque, Maria Àngels, Mataro Serrat, Maria, Pueyo Benito, Roser, Sala Llonch, Roser, Barrué Subirana, Cristian, Béjar Alonso, Javier, Cortés García, Claudio Ulises, Garolera, Maite, Junqué Plaja, Carme, Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, Universitat Politècnica de Catalunya. IDEAI-UPC - Intelligent Data sciEnce and Artificial Intelligence Research Group, Ariza, Mar, Cano, Neus, Segura Fàbregas, Bàrbara, Adan Puig, Ana, Bargalló Alabart, Núria, Caldú Ferrús, Xavier, Campabadal Delgado, Anna, Jurado Luque, Maria Àngels, Mataro Serrat, Maria, Pueyo Benito, Roser, Sala Llonch, Roser, Barrué Subirana, Cristian, Béjar Alonso, Javier, Cortés García, Claudio Ulises, Garolera, Maite, and Junqué Plaja, Carme

Abstract

Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature, Patients with post-coronavirus disease 2019 (COVID-19) conditions typically experience cognitive problems. Some studies have linked COVID-19 severity with long-term cognitive damage, while others did not observe such associations. This discrepancy can be attributed to methodological and sample variations. We aimed to clarify the relationship between COVID-19 severity and long-term cognitive outcomes and determine whether the initial symptomatology can predict long-term cognitive problems. Cognitive evaluations were performed on 109 healthy controls and 319 post-COVID individuals categorized into three groups according to the WHO clinical progression scale: severe-critical (n¿=¿77), moderate-hospitalized (n¿=¿73), and outpatients (n¿=¿169). Principal component analysis was used to identify factors associated with symptoms in the acute-phase and cognitive domains. Analyses of variance and regression linear models were used to study intergroup differences and the relationship between initial symptomatology and long-term cognitive problems. The severe-critical group performed significantly worse than the control group in general cognition (Montreal Cognitive Assessment), executive function (Digit symbol, Trail Making Test B, phonetic fluency), and social cognition (Reading the Mind in the Eyes test). Five components of symptoms emerged from the principal component analysis: the “Neurologic/Pain/Dermatologic” “Digestive/Headache”, “Respiratory/Fever/Fatigue/Psychiatric” and “Smell/ Taste” components were predictors of Montreal Cognitive Assessment scores; the “Neurologic/Pain/Dermatologic” component predicted attention and working memory; the “Neurologic/Pain/Dermatologic” and “Respiratory/Fever/Fatigue/Psychiatric” components predicted verbal memory, and the “Respiratory/Fever/Fatigue/Psychiatric,” “Neurologic/Pain/Dermatologic,” and “Digestive/Headache” components predicted executive function. Patients with severe COVID-19 exhibited persistent deficits in executive fun, This research was supported by the Agency for Management of University and Research Grants (AGAUR) from the Generalitat de Catalunya (Pandemies, 202PANDE00053) and La Marató de TV3 Foundation (202111-30-31-32)., Peer Reviewed, Article signat per 16 autors/es: Mar Ariza, Neus Cano, Bàrbara Segura, Ana Adan, Núria Bargalló, Xavier Caldú, Anna Campabadal, Maria Angeles Jurado, Maria Mataró, Roser Pueyo, Roser Sala‑Llonch, Cristian Barrué, Javier Bejar, Claudio Ulises Cortés on behalf of NAUTILUS Project Collaborative Group, Maite Garolera Carme Junqué, Postprint (published version)

Published
2023

123. Un paso más en la investigación en Trabajo Social: aportaciones de la Metodología Comunicativa

Author

Teresa Plaja Viñas

Subjects
investigación, Trabajo Social, Metodología Comunicativa, impacto social, Ethnology. Social and cultural anthropology, GN301-674
Abstract

Desde los inicios del Trabajo Social se ha remarcado la importancia de la investigación como herramienta para alcanzar su objetivo: el cambio social en base a la defensa de los derechos humanos y la justicia social. Sin embargo, en la actualidad persiste una brecha entre investigación y práctica. Ante esta situación que limita su capacidad de transformación, el Trabajo Social no se ha quedado estático, sino que ha buscado vías para superarlo. Este artículo presenta la Metodología Comunicativa y su ya demostrado impacto social, como una vía para contribuir a la reducción de la brecha entre investigación y práctica. Aunque el primer estudio basado en ella se centró en el pueblo gitano, en la actualidad se desarrolla ya en casi todos los contextos en los que interviene el Trabajo Social. Ante la importancia de respetar los principios del Trabajo Social para alcanzar sus objetivos, el presente artículo explora el encaje de la Metodología Comunicativa en la investigación en nuestro ámbito. Para ello se ponen en relación los objetivos y principios del Trabajo Social establecidos por la IFSW con los de esta metodología.

Published
2019
Full Text
View/download PDF

124. 'El Ciervo' cumple 65 años

Author

Foix, Lluís, Amusco, Alejandro Duque, Casanova, J. A. González, Gomis, Soledad, Rico, Francisco, Rovira, Francesc X. Puig, Bilbeny, Norbert, Rey, Fernando, Elorriaga, Xabier, Giner, Salvador, Majó, Joan, Escorsa, Pere, Jou, David, Cierco, Eduardo, Mollá, Juan, Pérez, Jordi, Corredor-Matheos, José, Lozano, José Jiménez, Camps, Victoria, Díaz-Plaja, Ana, Montalvo, Eugenio Gay, and Montobbio, Lucía

Published
2016

125. ¿Es usted tolerante?

Author

Pombo, Álvaro, Molina, Josefina, Aznar, Hugo, del Río, Pilar, Ortuño, Pascual, Contreras, Antonio Salido, Díaz-Plaja, Ana, Servetto, Marcelo, Pérez, Francisco Javier, Masip, Antonio, and Montalvo, Eugeni Gay

Published
2016

126. Anàlisi del descens de la natalitat durant la pandèmia de la COVID-19 a l’Alt Empordà

Author

Nieto Ortiz, Adrián, Fontova-Almató, Aurora, Turró-Garriga, Oriol, Plaja Roman, Pere, Institut de Recerca Glòria Compte, Fundació Salut Empordà, Figueres, Spain, and Fundació Salut Empordà

Subjects
técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::tasa de embarazos::tasa de natalidad [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], instalaciones, servicios y personal de asistencia sanitaria::centros sanitarios::hospitales [ATENCIÓN DE SALUD], Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Health Care Facilities, Manpower, and Services::Health Facilities::Hospitals [HEALTH CARE], Naixement - Estadístiques, COVID-19 (Malaltia), Hospitals, Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Pregnancy Rate::Birth Rate [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT]
Abstract

Natalitat; COVID-19; Hospital comarcal Natalidad; COVID-19; Hospital comarcal Natality; COVID-19; Country hospital S'entén per natalitat el nombre de nascuts vius que es produeix en un territori. Aquesta dada unida a l'estadística de defuncions permet estimar el creixement de la població. A la comarca de l'Alt Empordà hi ha hagut un increment significatiu de la població immigrada en els últims anys, fins a situar-se actualment a prop del 25%. Aquest fet ha impactat tant en el creixement de la població com també en la natalitat en els darrers anys, una situació que s’ha alterat amb la COVID-19. L’objectiu d’aquest estudi va ser comparar el nombre de parts a la Fundació Salut Empordà (FSE) el 2022 respecte al període 2020-2021 i analitzar l’evolució de la taxa de naixements a la comarca de l’Alt Empordà durant el període 1998-2022.

Published
2023

127. Evolució de la mortalitat durant la pandèmia de COVID-19 a un hospital comarcal (2020-2022)

Author

Fontova-Almató, Aurora, Nieto Ortiz, Adrián, Turró-Garriga, Oriol, Saguer Oliva, Montserrat, Plaja Roman, Pere, Institut de Recerca Glòria Compte, Fundació Salut Empordà, Figueres, Spain, and Fundació Salut Empordà

Subjects
Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad [Otros calificadores], Other subheadings::Other subheadings::Other subheadings::/mortality [Other subheadings], virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], instalaciones, servicios y personal de asistencia sanitaria::centros sanitarios::hospitales [ATENCIÓN DE SALUD], COVID-19 (Malaltia) - Mortalitat, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Health Care Facilities, Manpower, and Services::Health Facilities::Hospitals [HEALTH CARE], Hospitals
Abstract

Mortalitat; COVID-19; Hospital comarcal Mortalidad; COVID-19; Hospital comarcal Mortality; COVID-19; County hospital L’objectiu de l’estudi va ser conèixer les causes de mortalitat i la seva evolució en el període d’aparició de la COVID-19 en un hospital comarcal.

Published
2023

128. Array study in fetuses with nuchal translucency above the 95th percentile: a 4-year observational single-centre study

Author

Edgar Coello-Cahuao, María Ángeles Sánchez-Durán, Inés Calero, María Teresa Higueras, Mayte Avilés García, Carlota Rodó, Nerea Maiz, Alberto Plaja Rustein, Neus Castells-Sarret, Carmen Mediano-Vizuete, and Elena Carreras

Subjects
Obstetrics and Gynecology, General Medicine
Abstract

To evaluate the performance of chromosomal microarray analysis (CMA) in fetuses with nuchal translucency (NT) 95th percentile. Secondary objectives were to analyze these results according to NT thickness, below or above 3.5 mm, and those without associated anomalies.This observational single-cohort study was conducted between 2015 and 2018 in fetuses with NT 95th percentile. Following an invasive test, quantitative fluorescence-polymerase chain reaction (QF-PCR) was performed, and if normal, CMA was performed. Pathogenic copy number variants (CNVs), non-reported pathogenic CNV, pathogenic autosomal recessive variants and variants of unknown significance (VUS) were analysed.One-hundred and sixty-two fetuses with NT 95th percentile, normal QF-PCR and CMA were included. Amongst 128 fetuses with NT between the 95th percentile and 3.5 mm, one (0.8%) had a pathogenic CNV, four (3.1%) had non-reported pathogenic CNV, one (0.8%) had pathogenic autosomal recessive variant and 13 (10.2%) had VUS. Amongst 34 fetuses with NT ≥ 3.5 mm, four (11.8%) had pathogenic CNV, one (2.9%) had non-reported pathogenic CNV, one (2.9%) had pathogenic autosomal recessive variant and four (11.8%) had VUS. Four in 162 (2.5%) fetuses had CNVs at the chromosome 16p13.11 region. Amongst 154 fetuses without structural abnormalities and normal QF-PCR, three (1.9%) had a pathogenic CNV, 5 (3.2%) had non-reported pathogenic CNV, one (0.6%) autosomal recessive pathogenic CNV and 16 (10.4%) had VUS.Pathogenic CNVs were found in 1% of fetuses with an NT thickness between the 95

Published
2022

129. Attosecond x-ray transient absorption spectroscopy in graphene

Author

Giovanni Cistaro, Luis Plaja, Fernando Martín, and Antonio Picón

Subjects
Physics, QC1-999
Abstract

Real-time observations of the coherent electron dynamics induced by ultrashort light pulses in condensed-matter systems have remained elusive due to limitations in existing attosecond devices. Here we show that attosecond transient absorption resulting from an IR-pump/x-ray probe numerical experiment performed in graphene unambiguously encodes the information of the coherent electron dynamics induced by the pump pulse. First, we demonstrate the possibility of tracking in real time the electron injection through the Dirac points. Second, we derive and demonstrate a simple semiclassical theory that correlates the energy structure and the action Berry phase with strong changes in the absorption spectrum around Van Hove singularities. Our work opens the way to the development of novel imaging techniques in condensed matter systems at the attosecond timescale.

Published
2021
Full Text
View/download PDF

130. Ultrafast sub-nanometer matter-wave temporal Talbot effect

Author

Ana García-Cabrera, Carlos Hernández-García, and Luis Plaja

Subjects
attophysics, low-dimensional solids, high harmonic generation, matter-wave optics, Talbot imaging, intense fields, Science, Physics, QC1-999
Abstract

The coherent manipulation of the electron wavefunction at the atomic spatial and temporal scales is the fundamental breakthrough underlying far-reaching ultrafast phenomena as high-order harmonic radiation and attosecond pulse generation. In this work, we present a next step in the coherent control of matter waves by translating the concept of Talbot interferometry to the subnanomenter–femtosecond realm. We study the high-harmonic emission from a periodic system irradiated by an intense mid-infrared laser beam at grazing incidence. Our calculations show that Bloch electrons, once ionized, follow a sequence of ultrafast (femtosecond) revivals associated with the temporal Talbot effect. We demonstrate that these revivals leave a distinct signature in the high-frequency harmonic spectrum, in the form of structures extending beyond the main spectral cutoff, toward the x-rays. The reinterpretation of the process of high-order harmonic generation as the temporal realization of a Talbot–Lau interferometer suggests high-harmonic spectroscopy as an appropriate scheme to develop subnanometer ultrafast Talbot interferometry.

Published
2021
Full Text
View/download PDF

131. Natural immunity to SARS-CoV-2 and breakthrough infections in vaccinated and unvaccinated patients with cancer

Author

Alessio Cortellini, Juan Aguilar-Company, Ramon Salazar, Mark Bower, Ailsa Sita-Lumsden, Andrea Plaja, Alvin J. X. Lee, Alexia Bertuzzi, Carlo Tondini, Nikolaos Diamantis, Clara Martinez-Vila, Aleix Prat, Eleanor Apthorp, Alessandra Gennari, David J. Pinato, Institut Català de la Salut, [Cortellini A] Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK. Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. [Aguilar-Company J] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Salazar R] Department of Medical Oncology, ICO L’Hospitalet, Oncobell Program (IDIBELL), CIBERONC, Hospitalet de Llobregat, Spain. [Bower M] Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK. [Sita-Lumsden A] Medical Oncology, Guy’s and St Thomas’ NHS Foundation Trust (GSTT), London, UK. [Plaja A] Medical Oncology Department, B-ARGO Group, IGTP, Catalan Institute of Oncology-Badalona, Badalona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Cancer Research, Càncer - Pacients, fenómenos del sistema inmunitario::inmunidad::inmunidad innata [FENÓMENOS Y PROCESOS], Coronavirus infections, Infeccions per coronavirus, neoplasias [ENFERMEDADES], COVID-19 Testing, Neoplasms, Immunitat natural, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Humans, Vacunació, SARS-CoV-2, Vaccination, Immunity, COVID-19, Cancer patients, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Immune System Phenomena::Immunity::Immunity, Innate [PHENOMENA AND PROCESSES], Immunity, Innate, Malalts de càncer, Neoplasms [DISEASES], Immunitat, Oncology, Hematologic Neoplasms, Reinfection, COVID-19 (Malaltia) - Vacunació
Abstract

Oncology; Public health; COVID-19 Oncología; Salud pública; COVID-19 Oncologia; Salut pública; COVID-19 Background Consolidated evidence suggests spontaneous immunity from SARS-CoV-2 is not durable, leading to the risk of reinfection, especially in the context of newly emerging viral strains. In patients with cancer who survive COVID-19 prevalence and severity of SARS-CoV-2 reinfections are unknown. Methods We aimed to document natural history and outcome from SARS-CoV-2 reinfection in patients recruited to OnCovid (NCT04393974), an active European registry enrolling consecutive patients with a history of solid or haematologic malignancy diagnosed with COVID-19. Results As of December 2021, out of 3108 eligible participants, 1806 COVID-19 survivors were subsequently followed at participating institutions. Among them, 34 reinfections (1.9%) were reported after a median time of 152 days (range: 40–620) from the first COVID-19 diagnosis, and with a median observation period from the second infection of 115 days (95% CI: 27–196). Most of the first infections were diagnosed in 2020 (27, 79.4%), while most of reinfections in 2021 (25, 73.5%). Haematological malignancies were the most frequent primary tumour (12, 35%). Compared to first infections, second infections had lower prevalence of COVID-19 symptoms (52.9% vs 91.2%, P = 0.0008) and required less COVID-19-specific therapy (11.8% vs 50%, P = 0.0013). Overall, 11 patients (32.4%) and 3 (8.8%) were fully and partially vaccinated against SARS-CoV-2 before the second infection, respectively. The 14-day case fatality rate was 11.8%, with four death events, none of which among fully vaccinated patients. Conclusion This study shows that reinfections in COVID-19 survivors with cancer are possible and more common in patients with haematological malignancies. Reinfections carry a 11% risk of mortality, which rises to 15% among unvaccinated patients, highlighting the importance of universal vaccination of patients with cancer. OnCovid is sponsored by Imperial College London and received direct project funding and infrastructural support by the NIHR Imperial Biomedical Research Centre (BRC). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. Neither sponsor nor the funders of the study had any role in study design, data collection, data analysis, data interpretation, or writing of the report. All authors had access to all the data reported in the study.

Published
2022

132. Impacte sobre les consultes de gastroenterologia infantil del programa de diagnòstic i maneig del dolor abdominal recurrent (DARE) a l'atenció primària

Author

Plaja Roman, Pere, Roig Fort, Nuria, Nieto, Rubén, Villalobos Arevalo, Pilar, Sora, Beatriz, Sitjar, Carme, [Plaja P, Roig N, Villalobos P] Fundació Salut Empordà, Figueres, Girona Spain. [Nieto R] Estudis de Ciències de la Salut, Universitat Oberta de Catalunya (UOC), Barcelona, Spain. [Sora B] Estudis de Psicologia i Ciències de l’Educació, Universitat Oberta de Catalunya (UOC), Barcelona, Spain. [Sitjar C] Institut Català de la Salut (ICS), Barcelona, Spain, and Fundació Salut Empordà

Subjects
afecciones patológicas, signos y síntomas::signos y síntomas::manifestaciones neurológicas::dolor::dolor abdominal [ENFERMEDADES], Dolor abdominal - Infants, Health Occupations::Medicine::Pediatrics [DISCIPLINES AND OCCUPATIONS], Gastroenterologia, Health Occupations::Medicine::Internal Medicine::Gastroenterology [DISCIPLINES AND OCCUPATIONS], profesiones sanitarias::medicina::pediatría [DISCIPLINAS Y OCUPACIONES], Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Pain::Abdominal Pain [DISEASES], profesiones sanitarias::medicina::medicina interna::gastroenterología [DISCIPLINAS Y OCUPACIONES], Atenció primària pediàtrica
Abstract

Dolor abdominal; DAREmpordà; Atenció primària Dolor abdominal; DAREmpordà; Atención primaria Abdominal pain; DAREmpordà; Primary health care Introducció: El dolor abdominal recurrent (DAR) és un motiu de consulta molt freqüent a l'atenció primària (AP): un 90-95% dels casos són de causa és funcional (Reust et al., 2018) i s'estima que un 30-40% dels pacients podrien millorar només amb la intervenció psicoeducativa i el seguiment del pediatre (Schlarb et al., 2011). Objectius: Determinar si el programa DARE millora la capacitat del pediatre d'AP en el diagnòstic i maneig del DAR, reduint les derivacions a la consulta de gastroenterologia infantil. Metodologia: S'ofereix als pediatres d'AP de l´àrea de referència d'un hospital comarcal un protocol d'avaluació i maneig del DAR i una eina psicoeducativa per als pacients i les seves famílies (programa DARE). S'analitzen de forma retrospectiva les derivacions de pacients de 4 a 15 anys amb DAR a la consulta de gastroenterologia infantil de l'hospital en 2 períodes d'un any de durada, abans i després de la introducció de DARE,i quants acaben diagnosticats de DAR funcional (DAF) Resultats: En el primer període es van derivar 42 pacients amb DAR (31,6% del total). En el segon període es van derivar 21 pacients amb DAR (20% del total) (p0,05) Conclusions: El programa DARE ha reduït significativament les derivacions per DAR des d'AP a les consultes de Gastroenterologia Infantil. En ambdós períodes, més de la meitat dels pacients derivats per DAR són orientats com a DAF.

Published
2022

133. Extreme-ultraviolet structured beams via high harmonic generation.

Author

Pandey, Alok Kumar, de las Heras, Alba, Román, Julio San, Serrano, Javier, Plaja, Luis, Baynard, Elsa, Pittman, Moana, Dovillaire, Guillaume, Kazamias, Sophie, Durfee, Charles G., Hernández-García, Carlos, and Guilbaud, Olivier

Subjects
HARMONIC generation, VECTOR beams, ANGULAR momentum (Mechanics), HARMONIC maps, TOPOLOGICAL property, NOBLE gases
Abstract

Vigorous efforts to harness the topological properties of light have enabled a multitude of novel applications. Translating the applications of structured light to higher spatial and temporal resolutions mandates their controlled generation, manipulation, and thorough characterization in the short-wavelength regime. Here, we resort to high-order harmonic generation (HHG) in a noble gas to upconvert near-infrared (IR) vector, vortex, and vector-vortex driving beams that are tailored, respectively, in their spin angular momentum (SAM), orbital angular momentum (OAM), and simultaneously in their SAM and OAM. We show that HHG enables the controlled generation of extreme-ultraviolet (EUV) vector beams exhibiting various spatially dependent polarization distributions, or EUV vortex beams with a highly twisted phase. Moreover, we demonstrate the generation of EUV vector-vortex beams (VVB) bearing combined characteristics of vector and vortex beams. We rely on EUV wavefront sensing to unambiguously affirm the topological charge scaling of the HHG beams with the harmonic order. Interestingly, our work shows that HHG allows for a synchronous controlled manipulation of SAM and OAM. These EUV structured beams bring in the promising scenario of their applications at nanometric spatial and sub-femtosecond temporal resolutions using a table-top harmonic source. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

135. Double Electron Recombination in Strongly Correlated System: Extended Secondary Plateau in UV-Driven High Harmonic Generation in the Soft X-ray Regime

Author

Wang, Siyang, primary, Yan, Jieyu, additional, de las Heras, Alba, additional, Song, Sirius, additional, Prodanov, Aleksandar, additional, Wu, Zhihan, additional, Hernández-García, Carlos, additional, Plaja, Luis, additional, Popmintchev, Dimitar, additional, and Popmintchev, Tenio, additional

Published
2023
Full Text
View/download PDF

137. ZDHHC15as a candidate gene for autism spectrum disorder

Author

Casellas‐Vidal, Dolors, primary, Mademont‐Soler, Irene, additional, Sánchez, Joana, additional, Plaja, Alberto, additional, Castells, Neus, additional, Camós, Maria, additional, Nieto‐Moragas, Javier, additional, del Mar García, Maria, additional, Rodriguez‐Solera, Celia, additional, Rivera, Helena, additional, Brunet, Joan, additional, Álvarez, Sara, additional, Perapoch, Josep, additional, Queralt, Xavier, additional, and Obón, María, additional

Published
2022
Full Text
View/download PDF

138. SARS-CoV-2 omicron (B.1.1.529)-related COVID-19 sequelae in vaccinated and unvaccinated patients with cancer: results from the OnCovid registry

Author

Alessio Cortellini, Josep Tabernero, Uma Mukherjee, Ramon Salazar, Anna Sureda, Clara Maluquer, Daniela Ferrante, Mark Bower, Rachel Sharkey, Oriol Mirallas, Andrea Plaja, Marc Cucurull, Ricard Mesia, Alessia Dalla Pria, Thomas Newsom-Davis, Mieke Van Hemelrijck, Ailsa Sita-Lumsden, Eleanor Apthorp, Bruno Vincenzi, Giuseppina Rita Di Fazio, Giuseppe Tonini, Francesco Pantano, Alexia Bertuzzi, Sabrina Rossi, Joan Brunet, Matteo Lambertini, Paolo Pedrazzoli, Federica Biello, Francesca D'Avanzo, Alvin J X Lee, Marianne Shawe-Taylor, Lucy Rogers, Cian Murphy, Lee Cooper, Ramis Andaleeb, Saira Khalique, Samira Bawany, Sarah Ahmed, M Carmen Carmona-García, Roser Fort-Culillas, Raquel Liñan, Federica Zoratto, Gianpiero Rizzo, Marta Perachino, Kris Doonga, Gianluca Gaidano, Riccardo Bruna, Andrea Patriarca, Clara Martinez-Vila, Ignacio Pérez Criado, Raffaele Giusti, Francesca Mazzoni, Lorenzo Antonuzzo, Armando Santoro, Alessandro Parisi, Paola Queirolo, Avinash Aujayeb, Lorenza Rimassa, Nikolaos Diamantis, Rossella Bertulli, Claudia A M Fulgenzi, Antonio D'Alessio, Isabel Ruiz-Camps, Nadia Saoudi-Gonzalez, David Garcia Illescas, Irene Medina, Laura Fox, Alessandra Gennari, Juan Aguilar-Company, David J Pinato, Joanne S Evans, Judith Swallow, Georgina Hanbury, Chris Chung, Meera Patel, Gino Dettorre, Katherine Belessiotis, Dolly Saorise, Eleanor Jones, Charlotte Moss, Beth Russell, Sarah Townsend, Amanda Jackson, Angela Loizidou, Martine Piccart, Fanny Pommeret, Emeline Colomba-Blameble, Aleix Prat, Claudia A Cruz, Roxana Reyes, Elia Segui, Javier Marco-Hernández, Margarita Viladot, Nadia Harbeck, Rachel Wuerstlein, Franziska Henze, Sven Mahner, Eudald Felip, Lorenza Scotti, Andrea Marrari, Federica Grosso, Vittorio Fusco, Sara Delfanti, Maura Rossi, Alberto Zambelli, Carlo Tondini, Lorenzo Chiudinelli, Michela Franchi, Michela Libertini, Salvatore Provenzano, Daniele Generali, Salvatore Grisanti, Alice Baggi, Valeria Tovazzi, Corrado Ficorella, Giampiero Porzio, Maristella Saponara, Marco Filetti, Marco Tucci, Rossana Berardi, Luca Cantini, Francesco Paoloni, Annalisa Guida, Sergio Bracarda, Maria Iglesias, Ana Sanchez de Torre, and Marco Tagliamento

Subjects
Malalts de càncer, Oncology, SARS-CoV-2, Vaccination, COVID-19, Cancer patients, Vacunació
Abstract

Background COVID-19 sequelae can affect about 15% of patients with cancer who survive the acute phase of SARS-CoV-2 infection and can substantially impair their survival and continuity of oncological care. We aimed to investigate whether previous immunisation affects long-term sequelae in the context of evolving variants of concern of SARS-CoV-2. Methods OnCovid is an active registry that includes patients aged 18 years or older from 37 institutions across Belgium, France, Germany, Italy, Spain, and the UK with a laboratory-confirmed diagnosis of COVID-19 and a history of solid or haematological malignancy, either active or in remission, followed up from COVID-19 diagnosis until death. We evaluated the prevalence of COVID-19 sequelae in patients who survived COVID-19 and underwent a formal clinical reassessment, categorising infection according to the date of diagnosis as the omicron (B.1.1.529) phase from Dec 15, 2021, to Jan 31, 2022; the alpha (B.1.1.7)-delta (B.1.617.2) phase from Dec 1, 2020, to Dec 14, 2021; and the pre-vaccination phase from Feb 27 to Nov 30, 2020. The prevalence of overall COVID-19 sequelae was compared according to SARS-CoV-2 immunisation status and in relation to post-COVID-19 survival and resumption of systemic anticancer therapy. This study is registered with ClinicalTrials.gov, NCT04393974. Findings At the follow-up update on June 20, 2022, 1909 eligible patients, evaluated after a median of 39 days (IQR 24-68) from COVID-19 diagnosis, were included (964 [ 50 center dot 7%] of 1902 patients with sex data were female and 938 [49 center dot 3%] were male). Overall, 317 (16 center dot 6%; 95% CI 14 center dot 8-18 center dot 5) of 1909 patients had at least one sequela from COVID-19 at the first oncological reassessment. The prevalence of COVID-19 sequelae was highest in the prevaccination phase (191 [19 center dot 1%; 95% CI 16 center dot 4-22 center dot 0] of 1000 patients). The prevalence was similar in the alpha-delta phase (110 [16 center dot 8%; 13 center dot 8- 20 center dot 3] of 653 patients, p=0 center dot 24), but significantly lower in the omicron phase (16 [6 center dot 2%; 3 center dot 5-10 center dot 2] of 256 patients, p

Published
2023

141. Moving towards Personalized Medicine in Muscle-Invasive Bladder Cancer: Where Are We Now and Where Are We Going?

Author

Juan Carlos Pardo, Vicenç Ruiz de Porras, Andrea Plaja, Cristina Carrato, Olatz Etxaniz, Oscar Buisan, and Albert Font

Subjects
muscle-invasive bladder cancer, chemotherapy, immunotherapy, personalized medicine, predictive biomarker, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Neoadjuvant cisplatin-based chemotherapy followed by radical cystectomy is the recommended treatment, with the highest level of evidence, for patients with muscle-invasive bladder cancer (MIBC). However, only a minority of patients receive this treatment, mainly due to patient comorbidities, the relatively small survival benefit, and the lack of predictive biomarkers to select those patients most likely to benefit from this multimodal approach. In addition, adjuvant chemotherapy has been recommended for patients with high-risk MIBC, although randomized trials have not provided conclusive evidence on the impact of this approach. At present, however, this situation is changing, largely due to our improved knowledge of the molecular biology of bladder cancer, which has enabled us to identify new prognostic and predictive biomarkers that can be used to select the most appropriate treatment for each patient. Moreover, new active treatments, especially immunotherapy, have shown promising results in the neoadjuvant setting. In addition, the gene expression profile of bladder tumors can be used to classify them into different subtypes, which correlate with specific clinical-pathological characteristics and with treatment response or resistance. Therefore, the main objective for the near future is to introduce these translational breakthroughs into routine clinical practice in order to personalize treatment for each patient.

Published
2020
Full Text
View/download PDF

142. Spectral signature of back reaction in correlated electron dynamics in intense electromagnetic fields

Author

Alba de las Heras, Carlos Hernández-García, and Luis Plaja

Subjects
Physics, QC1-999
Abstract

Few-electron atoms interacting with electromagnetic fields provide for privileged scenarios for disentangling elemental correlation mechanisms. We demonstrate that high-order harmonic generation (HHG) from neutral helium presents a distinctive trace of correlation back reaction in the electron dynamics prior to ionization. We identify a mechanism in which the field interacts with one of the electrons, while the second is excited to a Rydberg level through the Coulomb interaction. As back response to this correlated excitation, the first electron is knocked down to a lower level, from which it ionizes to generate high-order harmonics. Unlike other multielectron phenomena, where the electron-field interaction is modified by cross correlations with the rest of the interacting electrons, back reaction is a mechanism of autocorrelation. Our numerical simulations reveal back reaction as a relevant aspect in HHG from correlated two-electron systems, and paves the way to disentangle valence electron-electron correlation dynamics using high-harmonic spectroscopy.

Published
2020
Full Text
View/download PDF

143. Site-specific tunnel-ionization in high harmonic generation in molecules

Author

Laura Rego, Carlos Hernández-García, Antonio Picón, and Luis Plaja

Subjects
high-harmonic spectroscopy, tunnel ionization, high harmonic generation in molecules, strong field approximation, ultrafast lasers, attosecond laser pulses, Science, Physics, QC1-999
Abstract

We demonstrate that the standard picture of strong-field tunnel-ionization from molecules should be reformulated. The extended nature of the molecular potential implies the separation of some of the molecular sites from the edge of the ionization barrier. We show that the dependence of the tunnel probability with the distance to the barrier is translated into the ionized wavepacket, modifying substantially the high-order harmonic emission. The introduction of the dependence of tunnel ionization with the molecular site significantly improves the theoretical description of high-order harmonic generation in molecules, which is used as a cornerstone in high-harmonic spectroscopy and attosecond imaging.

Published
2020
Full Text
View/download PDF

144. LRBA Deficiency in a Patient With a Novel Homozygous Mutation Due to Chromosome 4 Segmental Uniparental Isodisomy

Author

Pere Soler-Palacín, Marina Garcia-Prat, Andrea Martín-Nalda, Clara Franco-Jarava, Jacques G. Rivière, Alberto Plaja, Daniela Bezdan, Mattia Bosio, Mónica Martínez-Gallo, Stephan Ossowski, and Roger Colobran

Subjects
primary immunodeficiency, LRBA deficiency, uniparental disomy, whole exome sequencing, comparative genomic hybridization array, Immunologic diseases. Allergy, RC581-607
Abstract

LRBA deficiency was first described in 2012 as an autosomal recessive disorder caused by biallelic mutations in the LRBA gene (OMIM #614700). It was initially characterized as producing early-onset hypogammaglobulinemia, autoimmune manifestations, susceptibility to inflammatory bowel disease, and recurrent infection. However, further reports expanded this phenotype (including patients without hypogammaglobulinemia) and described LRBA deficiency as a clinically variable syndrome with a wide spectrum of clinical manifestations. We present the case of a female patient who presented with type 1 diabetes, psoriasis, oral thrush, and enlarged liver and spleen at the age of 8 months. She later experienced recurrent bacterial and viral infections, including pneumococcal meningitis and Epstein Barr viremia. She underwent two consecutive stem cell transplants at the age of 8 and 9 years, and ultimately died. Samples from the patient and her parents were subjected to whole exome sequencing, which revealed a homozygous 1-bp insertion in exon 23 of the patient's LRBA gene, resulting in frameshift and premature stop codon. The patient's healthy mother was heterozygous for the mutation and her father tested wild-type. This finding suggested that either one copy of the paternal chromosome 4 bore a deletion including the LRBA locus, or the patient inherited two copies of the mutant maternal LRBA allele. The patient's sequencing data showed a 1-Mb loss of heterozygosity region in chromosome 4, including the LRBA gene. Comparative genomic hybridization array of the patient's and father's genomic DNA yielded normal findings, ruling out genomic copy number abnormalities. Here, we present the first case of LRBA deficiency due to a uniparental disomy (UPD). In contrast to classical Mendelian inheritance, UPD involves inheritance of 2 copies of a chromosomal region from only 1 parent. Specifically, our patient carried a small segmental isodisomy of maternal origin affecting 1 Mb of chromosome 4.

Published
2018
Full Text
View/download PDF

145. Profilaxis de la Tetania Post-Operatoria

Author

Antonio Ordónez Plaja

Subjects
Tetania Post-Operatoria, Hipoparatiroidismo Post-Operatorio, Tetania Paratireopriva, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Se analizan algunas publicaciones recientes sobre irrigación de las glándulas paratiroides y sus implicaciones quirúrgicas. Se presentan algunas observaciones personales. Se concluye que mientras no se demuestre que la supresión de toda la irrigación arterial del tiroides es siempre inocua, es preferible no ligar los troncos de las arterias tiroidianas inferiores en atención a que la gravedad de la tetania post-operatoria hace indispensable reducir su incidencia a una cifra lo más cercana posible al cero por ciento.

Published
2018
Full Text
View/download PDF

147. Novel Double Factor PGT strategy analyzing blastocyst stage embryos in a single NGS procedure.

Author

Javier Del Rey, Francisco Vidal, Lorena Ramírez, Nina Borràs, Irene Corrales, Iris Garcia, Olga Martinez-Pasarell, Silvia F Fernandez, Raquel Garcia-Cruz, Aïda Pujol, Alberto Plaja, Itziar Salaverria, Maria Oliver-Bonet, Jordi Benet, and Joaquima Navarro

Subjects
Medicine, Science
Abstract

In families at risk from monogenic diseases affected offspring, it is fundamental the development of a suitable Double Factor Preimplantation Genetic Testing (DF-PGT) method for both single-gene analysis and chromosome complement screening. Aneuploidy is not only a major issue in advanced-maternal-age patients and balanced translocation carriers, but also the aneuploidy rate is extremely high in patients undergoing in vitro fertilization (IVF), even in young donors. To adequate NGS technology to the DF-PGT strategy four different whole genome amplification systems (Sureplex, MALBAC, and two multiple displacement amplification systems-MDA) were tested using TruSight One panel on cell lines and blastocyst trophectoderm biopsies-TE. Embryo cytogenetic status was analyzed by Nexus software. Sureplex and MALBAC DNA products were considered not suitable for PGT diagnosis due to inconsistent and poor results on Trusight one (TSO) panel. Results obtained with both MDA based methods (GEH-MDA and RG-MDA) were appropriate for direct mutation detection by TSO NGS platform. Nevertheless, RG-MDA amplification products showed better coverage and lower ADO rates than GEH-MDA. The present work also demonstrates that the same TSO sequencing data is suitable not only for the direct mutation detection, but also for the indirect mutation detection by linkage analysis of informative SNPs. The present work also demonstrates that Nexus software is competent for the detection of CNV by using with TSO sequencing data from RG-MDA products, allowing for the whole cytogenetic characterization of the embryos. In conclusion, successfully development of an innovative and promising DF-PGT strategy using TSO-NGS technology in TE biopsies, performed in-house in a single laboratory experience, has been done in the present work. Additional studies should be performed before it could be used as a diagnostic alternative in order to validate this approach for the detection of chromosomal aneuploidies.

Published
2018
Full Text
View/download PDF

149. Efectes de la COVID-19 en el personal sanitari durant la primera onada

Author

Fontova Almató, Aurora, Basurto-Oña, Xavier, Salleras-Duran, Laia, Frigola Frigolé, Anna, Rodríguez-Jareño, Mari Cruz, Plaja Roman, Pere, [Fontova Almató A, Basurto Oña X, Salleras Duran L, Frigola Frigolé A, Plaja Roman P] Hospital de Figueres, Fundació Salut Empordà, Figueres, Spain. [Rodríguez Jareño MC] Hospital de Palamós, Serveis de Salut Integrats Baix Empordà, Palamós, Spain, and Fundació Salut Empordà

Subjects
Personal sanitari, Population Characteristics::Health::Occupational Health [HEALTH CARE], virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Persons::Occupational Groups::Health Personnel [NAMED GROUPS], Salut en el treball, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Características de la Población::salud::salud laboral [ATENCIÓN DE SALUD], COVID-19 (Malaltia), personas::grupos profesionales::personal sanitario [DENOMINACIONES DE GRUPOS]
Abstract

Personal de la salut; Infeccions per coronavirus; Salut laboral Personal de la salud; Infecciones por coronavirus; Salud laboral Health personnel; Coronavirus infections; Occupational health En el personal sanitari (PS), la transmissió a l’inici de la epidèmia de COVID-19 va ser elevada i va anar disminuint a mida que es varen anar prenent mesures de protecció individual adequades. L'objectiu va ser conèixer els efectes que ha tingut la COVID-19 en el personal sanitari del nostre entorn.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results