10,525 results on '"Porcu, A."'
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102. Robust QUIC-Based Signalling for WebRTC in Impaired Networks.
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Luigi Serreli, Gülnaziye Bingöl, Simone Porcu, Alessandro Floris, and Marco Martalò
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- 2023
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103. Analysis of Application-layer Data to Estimate the QoE of WebRTC-based Audiovisual Conversations.
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MohammadAli Hamidi, Gülnaziye Bingöl, Alessandro Floris, Simone Porcu, and Luigi Atzori
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- 2023
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104. An Analysis of the Trade-Off Between Sustainability and Quality of Experience for Video Streaming.
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Gülnaziye Bingöl, Simone Porcu, Alessandro Floris, and Luigi Atzori
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- 2023
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105. A Clustered Federated Learning Approach for Estimating the Quality of Experience of Web Users.
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Simone Porcu, Alessandro Floris, and Luigi Atzori
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- 2023
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106. Are Quality and Sustainability Reconcilable? A Subjective Study on Video QoE, Luminance and Resolution.
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Gülnaziye Bingöl, Alessandro Floris, Simone Porcu, Christian Timmerer, and Luigi Atzori
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- 2023
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107. Energy Saving Architecture based on Android TV in a Smart Home Environment.
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Alessandro Floris, Simone Porcu, Luigi Atzori, Mauro Fadda, Matteo Anedda, Cristinel Gavrila, Vlad Popescu, and Daniele D. Giusto
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- 2023
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108. Personalized Surgical Planning in Liver Surgery Using Virtual 3D-Models
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Perra, Teresa, Porcu, Alberto, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Das, Asit Kumar, editor, Nayak, Janmenjoy, editor, Naik, Bighnaraj, editor, Vimal, S., editor, and Pelusi, Danilo, editor
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- 2023
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109. Smart5Grid Testing Strategy & Field Implementations for RT Wide Area Monitoring of Interconnected Systems
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Chochliouros, Ioannis P., Brodimas, Dimitrios, Tzanis, Nikolaos, Rantopoulos, Michalis, Shangov, Daniel, Hristov, Georgi, Velkov, Atanas, Ciornei, Irina, Porcu, Daniele, Rannenberg, Kai, Editor-in-Chief, Soares Barbosa, Luís, Editorial Board Member, Goedicke, Michael, Editorial Board Member, Tatnall, Arthur, Editorial Board Member, Neuhold, Erich J., Editorial Board Member, Stiller, Burkhard, Editorial Board Member, Stettner, Lukasz, Editorial Board Member, Pries-Heje, Jan, Editorial Board Member, Kreps, David, Editorial Board Member, Rettberg, Achim, Editorial Board Member, Furnell, Steven, Editorial Board Member, Mercier-Laurent, Eunika, Editorial Board Member, Winckler, Marco, Editorial Board Member, Malaka, Rainer, Editorial Board Member, Maglogiannis, Ilias, editor, Iliadis, Lazaros, editor, Papaleonidas, Antonios, editor, and Chochliouros, Ioannis, editor
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- 2023
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110. Spectral Simulation of Gaussian Vector Random Fields on the Sphere
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Alegría, Alfredo, Emery, Xavier, Freulon, Xavier, Lantuéjoul, Christian, Porcu, Emilio, Renard, Didier, Bezaeva, Natalia S., Series Editor, Gomes Coe, Heloisa Helena, Series Editor, Nawaz, Muhammad Farrakh, Series Editor, Avalos Sotomayor, Sebastian Alejandro, editor, Ortiz, Julian M., editor, and Srivastava, R. Mohan, editor
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- 2023
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111. A Phase Ib Study of Atezolizumab with Radium-223 Dichloride in Men with Metastatic Castration-Resistant Prostate CancerPhase Ib Trial of Atezo + Radium-223 in Pts with mCRPC
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Fong, Lawrence, Morris, Michael J, Sartor, Oliver, Higano, Celestia S, Pagliaro, Lance, Alva, Ajjai, Appleman, Leonard J, Tan, Winston, Vaishampayan, Ulka, Porcu, Raphaelle, Tayama, Darren, Kadel, Edward E, Yuen, Kobe C, Datye, Asim, Armstrong, Andrew J, and Petrylak, Daniel P
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Cancer ,Clinical Research ,Urologic Diseases ,Clinical Trials and Supportive Activities ,Prostate Cancer ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Adult ,Aged ,Aged ,80 and over ,Antibodies ,Monoclonal ,Humanized ,Combined Modality Therapy ,Double-Blind Method ,Humans ,Immune Checkpoint Inhibitors ,Male ,Middle Aged ,Neoplasm Metastasis ,Prostatic Neoplasms ,Castration-Resistant ,Radium ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
PurposeMen with metastatic castration-resistant prostate cancer (mCRPC) have limited treatment options after progressing on hormonal therapy and chemotherapy. Here, we evaluate the safety and efficacy of atezolizumab (anti-PD-L1) + radium-223 dichloride (radium-223) in men with mCRPC.Patients and methodsThis phase Ib study evaluated atezolizumab + radium-223 in men with mCRPC and bone and lymph node and/or visceral metastases that progressed after androgen pathway inhibitor treatment. Following safety assessment of concurrent dosing, 45 men were randomized 1:1:1 to concurrent or one of two staggered dosing schedules with either agent introduced one cycle before the other. This was followed by a safety-efficacy expansion cohort (randomized 1:1:1). The primary endpoints were safety and objective response rate (ORR) by RECIST 1.1. Secondary endpoints included radiographic progression-free survival (rPFS), PSA responses, and overall survival (OS).ResultsAs of October 4, 2019, 44 of 45 men were evaluable. All 44 had ≥1 all-cause adverse event (AE); 23 (52.3%) had a grade 3/4 AE. Fifteen (34.1%) grade 3/4 and 3 (6.8%) grade 5 AEs were related to atezolizumab; none were related to radium-223. Confirmed ORR was 6.8% [95% confidence interval (CI), 1.4-18.7], median rPFS was 3.0 months (95% CI, 2.8-4.6), median PSA progression was 3.0 months (95% CI, 2.8-3.3), and median OS was 16.3 months (95% CI, 10.9-22.3).ConclusionsThis phase Ib study demonstrated that atezolizumab + radium-223, regardless of administration schedule, had greater toxicity than either drug alone, with no clear evidence of additional clinical benefit for patients with mCRPC and bone and lymph node and/or visceral metastases.
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- 2021
112. Breast MRI: Clinical Indications, Recommendations, and Future Applications in Breast Cancer Diagnosis
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Wekking, Demi, Porcu, Michele, De Silva, Pushpamali, Saba, Luca, Scartozzi, Mario, and Solinas, Cinzia
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- 2023
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113. A catalogue of nonseparable positive semidefinite kernels on the product of two spheres
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Emery, Xavier, Peron, Ana Paula, and Porcu, Emilio
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- 2023
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114. Does education protect families' well-being in times of crisis? Measurement issues and empirical findings from IT-SILC data
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Giambona, Francesca, Porcu, Mariano, and Sulis, Isabella
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- 2023
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115. Action prediction modulates self–other integration in joint action
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van der Weiden, Anouk, Porcu, Emanuele, and Liepelt, Roman
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- 2023
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116. Ontogenetic changes in the tyrosine hydroxylase immunoreactive preoptic area in the small-spotted catshark Scyliorhinus canicula (L., 1758) females: catecholaminergic involvement in sexual maturation
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Riccardo Porceddu, Cristina Porcu, Giovanna Mulas, Saturnino Spiga, and Maria Cristina Follesa
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Scyliorhinus canicula ,brain ,preoptic nucleus ,stereology ,ontogenetic changes ,shark ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Human anatomy ,QM1-695 - Abstract
IntroductionThe catecholaminergic component of the brain-pituitary-gonadal axis, which mediates the influence of external and internal stimuli on the central nervous system and gonad development in vertebrates, is largely unexplored in Chondrichthyes. We considered Scyliorhinus canicula (L., 1758) females as a model for this vertebrate's class, to assess the involvement of the catecholaminergic system of the brain in its reproduction. Along the S. canicula reproductive cycle, we characterized and evaluated differences in somata morphometry and the number of putative catecholaminergic neurons in two brain nuclei: the periventricular preoptic nucleus, hypothesized to be a positive control for ovarian development, and the suprachiasmatic nucleus, examined as a negative control.Materials and methods16 S. canicula wild females were sampled and grouped in maturity stages (immature, maturing, mature, and mature egg-laying). The ovary was histologically processed for the qualitative description of maturity stages. Anti-tyrosine hydroxylase immunofluorescence was performed on the diencephalic brain sections. The immunoreactive somata were investigated for morphometry and counted using the optical fractionator method, throughout the confocal microscopy.Results and discussionsQualitative and quantitative research confirmed two separate populations of immunoreactive neurons. The modifications detected in the preoptic nucleus revealed that somata were more numerous, significantly smaller in size, and more excitable during the maturing phase but decreased, becoming slightly bigger and less excitable in the egg-laying stage. This may indicate that the catecholaminergic preoptic nucleus is involved in the control of reproduction, regulating both the onset of puberty and the imminent spawning. In contrast, somata in the suprachiasmatic nucleus grew in size and underwent turnover in morphometry, increasing the total number from the immature-virgin to maturing stage, with similar values in the more advanced maturity stages. These changes were not linked to a reproductive role. These findings provide new valuable information on Chondrichthyes, suggesting the existence of an additional brain system implicated in the integration of internal and environmental cues for reproduction.
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- 2024
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117. Unifying Compactly Supported and Matern Covariance Functions in Spatial Statistics
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Bevilacqua, M., Caamaño-Carrillo, C., and Porcu, E.
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Mathematics - Statistics Theory - Abstract
The Mat{\'e}rn family of covariance functions has played a central role in spatial statistics for decades, being a flexible parametric class with one parameter determining the smoothness of the paths of the underlying spatial field. This paper proposes a new family of spatial covariance functions, which stems from a reparameterization of the generalized Wendland family. As for the Mat{\'e}rn case, the new class allows for a continuous parameterization of the smoothness of the underlying Gaussian random field, being additionally compactly supported. More importantly, we show that the proposed covariance family generalizes the Mat{\'e}rn model which is attained as a special limit case. The practical implication of our theoretical results questions the effective flexibility of the Mat{\'e}rn covariance from modeling and computational viewpoints. Our numerical experiments elucidate the speed of convergence of the proposed model to the Mat{\'e}rn model. We also inspect the level of sparseness of the associated (inverse) covariance matrix and the asymptotic distribution of the maximum likelihood estimator under increasing and fixed domain asymptotics. The effectiveness of our proposal is illustrated by analyzing a georeferenced dataset on maximum temperatures over the southeastern United States, and performing a re-analysis of a large spatial point referenced dataset of yearly total precipitation anomalies
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- 2020
118. Asymptotically Equivalent Prediction in Multivariate Geostatistics
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Bachoc, François, Porcu, Emilio, Bevilacqua, Moreno, Furrer, Reinhard, and Faouzi, Tarik
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Mathematics - Statistics Theory - Abstract
Cokriging is the common method of spatial interpolation (best linear unbiased prediction) in multivariate geostatistics. While best linear prediction has been well understood in univariate spatial statistics, the literature for the multivariate case has been elusive so far. The new challenges provided by modern spatial datasets, being typically multivariate, call for a deeper study of cokriging. In particular, we deal with the problem of misspecified cokriging prediction within the framework of fixed domain asymptotics. Specifically, we provide conditions for equivalence of measures associated with multivariate Gaussian random fields, with index set in a compact set of a d-dimensional Euclidean space. Such conditions have been elusive for over about 50 years of spatial statistics. We then focus on the multivariate Mat\'ern and Generalized Wendland classes of matrix valued covariance functions, that have been very popular for having parameters that are crucial to spatial interpolation, and that control the mean square differentiability of the associated Gaussian process. We provide sufficient conditions, for equivalence of Gaussian measures, relying on the covariance parameters of these two classes. This enables to identify the parameters that are crucial to asymptotically equivalent interpolation in multivariate geostatistics. Our findings are then illustrated through simulation studies.
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- 2020
119. Development and external validation of a predictive multivariable model for last-weeks survival of advanced cancer patients in the palliative home care setting (PACS)
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Porcu, Luca, Recchia, Angela, Bosetti, Cristina, Chiaruttini, Maria Vittoria, Uggeri, Sara, Lonati, Giada, Ubezio, Paolo, Rizzi, Barbara, and Corli, Oscar
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- 2023
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120. Unveiling Hidden Prints: Optically stimulated luminescence for latent fingerprint detection
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Andrea Pinna, Sofia Rocca, Stefania Porcu, Roberto Cardia, Daniele Chiriu, Carlo M. Carbonaro, Riccardo Corpino, Enrica Tuveri, Pietro Coli, and Pier Carlo Ricci
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Optical stimulated luminescence ,Applied optics ,Fingerprint detection ,Ba2SiO4 ,Forensic applications ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Fluorescent lighting and optical techniques have been widely utilized to enhance the detection of latent fingerprints. However, the development of new techniques is imperative to expand the range of surfaces from which latent fingerprints can be detected. When relying on traditional methods, fingerprint evidence can remain undetected or even disregarded due to insufficient detection and limited detail, especially when dealing with a luminescent background.In this study, we propose the utilization of optically stimulated luminescence (OSL) applied to a Ba2SiO4 matrix, co-doped with Eu2+ and Dy3+, as a powerful method for visualizing latent fingerprints on various surfaces, including thin plastic bags, rigid duct tape, thin aluminum foil, and glass slices. This technique effectively eliminates any luminescent background and significantly enhances optical imaging.This represents the first successful application of OSL in the development of latent fingerprints, thus paving the way for more efficient and effective forensic techniques in the future.
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- 2023
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121. Utility of T-cell immunosequencing in distinguishing mycosis fungoides progression from treatment related cutaneous adverse events
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Safiyyah Bhatti, Daniel Joffe, Lauren Banner, Sahithi Talasila, Jenna Mandel, Jason Lee, Pierluigi Porcu, and Neda Nikbakht
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T-cell immunosequencing ,mogamulizumab ,mogamulizumab associated rash ,mycosis fungoides ,mechlorethamine gel ,Medicine (General) ,R5-920 - Abstract
Cutaneous adverse events of both topical and systemic drugs in patients with mycosis fungoides (MF) present a diagnostic challenge as it is often difficult to distinguish drug associated rash from disease progression in the skin. Mogamulizumab and mechlorethamine gel are approved treatments for MF, both of which can cause treatment related cutaneous adverse events. It can often be challenging to distinguish mogamulizumab associated rash (MAR) and mechlorethamine gel associated hypersensitivity dermatitis from MF progression both clinically and histologically. High-throughput sequencing (HTS) of the T-cell receptor (TCR), also known as immunosequencing, can be used to assess T-cell clonality to support a diagnosis of MF. After identification of the malignant TCR clone at baseline, immunosequencing can track the established malignant TCR sequence and its frequency over time with high sensitivity. As a result, immunosequencing clone tracking can aid in distinguishing disease progression from treatment side effects. Here, we present a case series to demonstrate how monitoring of the malignant T-cell frequency by immunosequencing can aid in diagnosis of mogamulizumab and mechlorethamine gel cutaneous adverse events.
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- 2023
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122. Reproductive health in Turner’s syndrome: from puberty to pregnancy
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Eleonora Porcu, Linda Cipriani, and Giuseppe Damiano
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Turner syndrome ,pubertal development ,fertility preservation ,mosaicism ,oocyte cryopreservation ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Turner syndrome (TS) is a genetic pathology that affects about 1/2500 newborn females. Turner’s syndrome is characterized by highly variable genetic anomalies that consist in a partial or complete deletion of the X sexual chromosome; it can be present as a monosomy or as a mosaicism with two o three different cellular lines. 50% of the patients with Turner’s syndrome has a 45 XO karyotype while the remaining cases have karyotypes with mosaicism or X isochromosome or with partial or whole Y chromosome. This pathology is characterized by multiple anomalies that involve physical and cognitive development and in particular endocrine, cardiovascular, reproductive, auditive and visual systems. Integrity of the X chromosome in essential for fertility. In TS is accelerated germ cells apoptosis. About 30% of TS girls have some pubertal development, 10-20% undergo menarche and 2-8% go through spontaneous pregnancy. Women with TS should be informed about the risk of premature menopause and should be referred, if possible, to a specialist evaluation with a doctor expert in assisted reproductive techniques. In adolescents and in adults, Premature Ovarian Insufficiency (POI) can be evaluated clinically and biochemically with the classic combination of amenorrhea and elevated FSH concentrations (hypergonadotropic hypogonadism). However, in postpubertal adolescents and adult women, reproductive hormones may remain within the normal range before POI is clinically evident, despite significant depletion of the ovarian reserve. Today, reproductive medicine offers the opportunity of fertility preservation in women with premature ovarian insufficiency (POI). Two techniques have been suggested such as ovarian cortex cryopreservation and oocytes cryopreservation.
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- 2023
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123. Effect of anti-P ribosomal and anti-NR2 antibodies on depression and cognitive processes in SLE: an integrated clinical and functional MRI study
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Alberto Cauli, Matteo Piga, Maria Maddalena Angioni, Alberto Floris, Mattia Congia, Alessandro Mathieu, Elisabetta Chessa, Alessandra Perra, Mauro Giovanni Carta, Luca Saba, Elisa Pintus, Michele Porcu, Cristina Serafini, and Micaela Rita Naitza
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Immunologic diseases. Allergy ,RC581-607 - Abstract
Objectives To explore the effects of anti-ribosomal P protein (anti-P) and anti-N-methyl-D-aspartic acid receptor subunit 2 (anti-NR2) autoantibodies on depression and cognitive dysfunction and their relationships with functional brain connectivity in SLE.Methods This cross-sectional study included adult patients who fulfilled the American College of Rheumatology/European Alliance of Associations for Rheumatology 2019 SLE criteria. Anti-P and anti-NR2 were quantified using ELISA. A 1-hour battery of neuropsychological testing interpreted by a neuropsychologist explored depressive symptoms (Center for Epidemiologic Studies Depression Scale, CES-D), cognitive domains and quality of life (SF-12). Resting-state functional connectivity (rs-fc) MRI analysis was performed within 1 month, and region-of-interest to region-of-interest (ROI-to-ROI) analyses with the graph theory were performed.Results Thirty-three patients with SLE (9% male) were enrolled, mean age (SD) of 43.5 (14) years and median disease duration of 10.4 years (2.9–25.4). Anti-P was positive in 6 (18.2%) and anti-NR2 in 14 (42.4%) patients. Depressive symptoms were found in 14 (42.4%) patients using the CES-D (range 0–51). After correction for age, disease duration, disease activity and white matter lesion load, the CES-D score was independently associated with anti-P serum level (β=0.32; p=0.049) and prednisone daily dose (β=0.38; p=0.023). Nineteen patients (57.6%) showed at least a cognitive test alteration, but no significant association with autoantibodies was found. The rs-fc MRI analysis revealed an independent association between the anti-P serum levels and many altered brain ROI properties but no anti-NR2 and prednisone effects on the cerebral network.Conclusions Anti-P was associated with brain network perturbation, which may be responsible for depressive symptoms in patients with SLE.
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- 2023
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124. Primary adrenal insufficiency induced by immune checkpoint inhibitors: biological, clinical, and radiological aspects
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Martella, Serafina, Lucas, Minke, Porcu, Michele, Perra, Laura, Denaro, Nerina, Pretta, Andrea, Deias, Giulia, Willard-Gallo, Karen, Parra, Hector Soto, Saba, Luca, Scartozzi, Mario, Wekking, Demi, Kok, Marleen, Aiello, Marco Maria, and Solinas, Cinzia
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- 2023
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125. Unveiling Hidden Prints: Optically stimulated luminescence for latent fingerprint detection
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Pinna, Andrea, Rocca, Sofia, Porcu, Stefania, Cardia, Roberto, Chiriu, Daniele, Carbonaro, Carlo M., Corpino, Riccardo, Tuveri, Enrica, Coli, Pietro, and Ricci, Pier Carlo
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- 2023
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126. Multidisciplinary clinical guidelines in proactive monitoring, early diagnosis, and effective management of trastuzumab deruxtecan (T-DXd)-induced interstitial lung disease (ILD) in breast cancer patients
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Wekking, D., Porcu, M., Pellegrino, B., Lai, E., Mura, G., Denaro, N., Saba, L., Musolino, A., Scartozzi, M., and Solinas, C.
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- 2023
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127. Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination
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Giuseppina Brancaccio, Barbara Coco, Alessandra Nardi, Maria Giovanna Quaranta, Maria Elena Tosti, Luigina Ferrigno, Irene Cacciola, Vincenzo Messina, Luchino Chessa, Filomena Morisco, Michele Milella, Francesco Barbaro, Alessia Ciancio, Francesco Paolo Russo, Nicola Coppola, Pierluigi Blanc, Ernesto Claar, Gabriella Verucchi, Massimo Puoti, Anna Linda Zignego, Liliana Chemello, Salvatore Madonia, Stefano Fagiuoli, Alfredo Marzano, Carlo Ferrari, Pietro Lampertico, Vito Di Marco, Antonio Craxì, Teresa Antonia Santantonio, Giovanni Raimondo, Maurizia R. Brunetto, Giovanni Battista Gaeta, Loreta A. Kondili, Luisa Pasulo, Carmine Coppola, Federica Pisano, Mariarosaria Romano, Carmen Porcu, Irene Francesca Bottalico, Valentina Cossiga, Xhimi Tata, Caterina Sagnelli, Piera Pierotti, Elisabetta Degasperi, Valerio Rosato, Lorenzo Badia, Dontella Ieluzzi, Monica Monti, Maria Grazia Bavetta, Luisa Cavalletto, Pierluigi Toniutto, Ezio Fornasiere, Antonio Colecchia, Alberto Ferrarese, Gerardo Nardone, Alba Rocco, Mauro Viganò, Francesco Giuseppe Foschi, Fabio Conti, Giulia Morsica, Stefania Salpietro, Carlo Torti, Chiara Costa, Alessandro Federico, Marcello Dallio, Alessia Giorgini, Marco Anselmo, Pasqualina De Leo, Serena Zaltron, Anna Cambianica, Fabio Piscaglia, Ilaria Serio, Simona Schivazappa, Antonio Mastroianni, Luciana Chidichimo, Marco Massari, Cesare Mazzaro, Aldo Marrone, Francesca Maria D'Amore, Gianpiero D'Offizi, Anna Licata, Grazia Anna Niro, Teresa Pollicino, and Alessio Aghemo
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Hepatitis B ,Chronic ,Hepatitis Delta ,Epidemiology ,Migrants ,Hepatitis control ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: The study measures trends in the profile of patients with chronic hepatitis B virus linked to care in Italy. Methods: A cross-sectional, multicenter, observational cohort (PITER cohort) of consecutive patients with hepatitis B surface antigen (HBsAg) over the period 2019-2021 from 46 centers was evaluated. The reference was the MASTER cohort collected over the years 2012-2015. Standard statistical methods were used. Results: The PITER cohort enrolled 4583 patients, of whom 21.8% were non-Italian natives. Compared with those in MASTER, the patients were older and more often female. The prevalence of hepatitis B e antigen (HBeAg) declined (7.2% vs 12.3; P
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- 2023
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128. Serious complications of pancreatoduodenectomy correlate with lower rates of adjuvant chemotherapy: Results from the recurrence after Whipple's (RAW) study
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Labib, Peter L., Russell, Thomas B., Streeter, Adam, Denson, Jemimah, Puckett, Mark, Zhou, Shang-Ming, Browning, Matthew, Aroori, Somaiah, Ausania, Fabio, Pando, Elizabeth, Roberts, Keith, Kausar, Ambareen, Mavroeidis, Vasileios K., Marangoni, Gabriele, Thomasset, Sarah, Frampton, Adam, Lykoudis, Pavlos, Maglione, Manuel, Alhaboob, Nassir, Bari, Hassaan, Smith, Andrew, Spalding, Duncan, Srinivasan, Parthi, Davidson, Brian, Bhogal, Ricky, Croagh, Daniel, Dominguez, Ismael, Thakkar, Rohan, Gomez, Dhanny, Silva, Michael, Lapolla, Pierfrancesco, Mingoli, Andrea, Porcu, Alberto, Shah, Nehal Sureshkumar, Hamady, Zaed, Al-Sarrieh, Bilal, Serrablo, Alejandro, Gonzalez-Abos, Carolina, Fernandes, Nair, Moller, Elsa Garcia, Taboada, Cristina Dopazo, Pande, Rupaly, Alfarah, Jameel, Bandyopadhyay, Samik, Abdelrahim, Ahmed, Khan, Ayesha, Jordan, Caitlin, Rees, Jonathan R.E., Blege, Harry, Cambridge, William, White, Olga, Blacker, Sarah, Blackburn, Jessie, Sweeney, Casie, Field, Daniel, Gouda, Mohammed, Bellotti, Ruben, Hamid, Hytham K.S., Ahmed, Hassan, Moriarty, Catherine, White, Louise, Priestley, Mark, Bode, Kerry, Sharp, Judith, Wragg, Rosie, Jackson, Beverley, Craven, Samuel, Fehervari, Matyas, Pai, Madhava, Alghazawi, Laith, Onifade, Anjola, Ribaud, Julliette, Nair, Ashitha, Mariathasan, Michael, Grayson, Niamh, Pericleous, Stephanos, Patel, Krishna, Shaw, Conrad, Morare, Nolitha, Zaban, Mohamad Khish, Doyle, Joseph, Guerrero, Alan, Moguel, Andre, Chan, Carlos, Jones, Michael, Buckley, Edward, Akter, Nasreen, Treherne, Kyle, Gordon, Gregory, Hughes, Daniel, Urbonas, Tomas, Brachini, Gioia, Caronna, Roberto, Chirletti, Piero, Perra, Teresa, Abd Kahar, Nurul Nadhirah, Hall, Thomas, Nadeem, Nabeegh, Karar, Shoura, Arshad, Ali, Yarwood, Adam, Hammoda, Mohammed, Artigas, Maria, Paterna-López, Sandra, Roberts, Keith J., Thomasset, Sarah C., Frampton, Adam E., Smith, Andrew M., Davidson, Brian R., Bhogal, Ricky H., Silva, Michael A., Shah, Nehal S., and Hamady, Zaed Z.R.
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- 2023
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129. Genome-wide Association Studies of Retinal Vessel Tortuosity Identify Numerous Novel Loci Revealing Genes and Pathways Associated With Ocular and Cardiometabolic Diseases
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Tomasoni, Mattia, Beyeler, Michael Johannes, Vela, Sofia Ortin, Mounier, Ninon, Porcu, Eleonora, Corre, Tanguy, Krefl, Daniel, Button, Alexander Luke, Abouzeid, Hana, Lazaros, Konstantinidis, Bochud, Murielle, Schlingemann, Reinier, Bergin, Ciara, and Bergmann, Sven
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- 2023
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130. Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry
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Abban, Dzifa Wosornu, Abdul, Nasser, Abud, Atilio Marcelo, Adams, Fran, Addala, Srinivas, Adragão, Pedro, Ageno, Walter, Aggarwal, Rajesh, Agosti, Sergio, Agostoni, Piergiuseppe, Aguilar, Francisco, Linares, Julio Aguilar, Aguinaga, Luis, Ahmed, Jameel, Aiello, Allessandro, Ainsworth, Paul, Aiub, Jorge Roberto, Al-Dallow, Raed, Alderson, Lisa, Aldrete Velasco, Jorge Antonio, Alexopoulos, Dimitrios, Manterola, Fernando Alfonso, Aliyar, Pareed, Alonso, David, Alves da Costa, Fernando Augusto, Amado, José, Amara, Walid, Amelot, Mathieu, Amjadi, Nima, Ammirati, Fabrizio, Andrade, Marianna, Andrawis, Nabil, Annoni, Giorgio, Ansalone, Gerardo, Ariani, M.Kevin, Arias, Juan Carlos, Armero, Sébastien, Arora, Chander, Aslam, Muhammad Shakil, Asselman, M., Audouin, Philippe, Augenbraun, Charles, Aydin, S., Ayryanova, Ivaneta, Aziz, Emad, Backes, Luciano Marcelo, Badings, E., Bagni, Ermentina, Baker, Seth H., Bala, Richard, Baldi, Antonio, Bando, Shigenobu, Banerjee, Subhash, Bank, Alan, Esquivias, Gonzalo Barón, Barr, Craig, Bartlett, Maria, Kes, Vanja Basic, Baula, Giovanni, Behrens, Steffen, Bell, Alan, Benedetti, Raffaella, Mazuecos, Juan Benezet, Benhalima, Bouziane, Bergler-Klein, Jutta, Berneau, Jean-Baptiste, Bernstein, Richard A., Berrospi, Percy, Berti, Sergio, Berz, Andrea, Best, Elizabeth, Bettencourt, Paulo, Betzu, Robert, Bhagwat, Ravi, Bhatta, Luna, Biscione, Francesco, Bisignani, Giovanni, Black, Toby, Bloch, Michael J., Bloom, Stephen, Blumberg, Edwin, Bo, Mario, Bøhmer, Ellen, Bollmann, Andreas, Bongiorni, Maria Grazia, Boriani, Giuseppe, Boswijk, D.J., Bott, Jochen, Bottacchi, Edo, Kalan, Marica Bracic, Bradman, Drew, Brautigam, Donald, Breton, Nicolas, Brouwers, P.J.A.M., Browne, Kevin, Cortada, Jordi Bruguera, Bruni, A., Brunschwig, Claude, Buathier, Hervé, Buhl, Aurélie, Bullinga, John, Cabrera, Jose Walter, Caccavo, Alberto, Cai, Shanglang, Caine, Sarah, Calò, Leonardo, Calvi, Valeria, Sánchez, Mauricio Camarillo, Candeias, Rui, Capuano, Vincenzo, Capucci, Alessandro, Caputo, Ronald, Rizo, Tatiana Cárdenas, Cardona, Francisco, Carlos da Costa Darrieux, Francisco, Duarte Vera, Yan Carlos, Carolei, Antonio, Carreño, Susana, Carvalho, Paula, Cary, Susanna, Casu, Gavino, Cavallini, Claudio, Cayla, Guillaume, Celentano, Aldo, Cha, Tae-Joon, Cha, Kwang Soo, Chae, Jei Keon, Chalamidas, Kathrine, Challappa, Krishnan, Chand, Sunil Prakash, Chandrashekar, Harinath, Chartier, Ludovic, Chatterjee, Kausik, Chavez Ayala, Carlos Antero, Cheema, Aamir, Cheema, Amjad, Chen, Lin, Chen, Shih-Ann, Chen, Jyh Hong, Chiang, Fu-Tien, Chiarella, Francesco, Chih-Chan, Lin, Cho, Yong Keun, Choi, Jong-Il, Choi, Dong Ju, Chouinard, Guy, Hoi-Fan Chow, Danny, Chrysos, Dimitrios, Chumakova, Galina, José Roberto, Eduardo Julián, Valenzuela, Chuquiure, Nica, Nicoleta Cindea, Cislowski, David J., Clay, Anthony, Clifford, Piers, Cohen, Andrew, Cohen, Michael, Cohen, Serge, Colivicchi, Furio, Collins, Ronan, Colonna, Paolo, Compton, Steve, Connolly, Derek, Conti, Alberto, Buenostro, Gabriel Contreras, Coodley, Gregg, Cooper, Martin, Coronel, Julian, Corso, Giovanni, Sales, Juan Cosín, Cottin, Yves, Covalesky, John, Cracan, Aurel, Crea, Filippo, Crean, Peter, Crenshaw, James, Cullen, Tina, Darius, Harald, Dary, Patrick, Dascotte, Olivier, Dauber, Ira, Davalos, Vicente, Davies, Ruth, Davis, Gershan, Davy, Jean-Marc, Dayer, Mark, De Biasio, Marzia, De Bonis, Silvana, De Caterina, Raffaele, De Franceschi, Teresiano, de Groot, J.R., De Horta, José, De La Briolle, Axel, Topete, Gilberto de la Pena, Vicenzo de Paola, Angelo Amato, de Souza, Weimar, de Veer, A., De Wolf, Luc, Decoulx, Eric, Deepak, Sasalu, Defaye, Pascal, Del-Carpio Munoz, Freddy, Brkljacic, Diana Delic, Deumite, N. Joseph, Di Legge, Silvia, Diemberger, Igor, Dietz, Denise, Dionísio, Pedro, Dong, Qiang, Rossi dos Santos, Fabio, Dotcheva, Elena, Doukky, Rami, D'Souza, Anthony, Dubrey, Simon, Ducrocq, Xavier, Dupljakov, Dmitry, Duque, Mauricio, Dutta, Dipankar, Duvilla, Nathalie, Duygun, A., Dziewas, Rainer, Eaton, Charles B., Eaves, William, Ebels-Tuinbeek; Clifford Ehrlich, L.A., Eichinger-Hasenauer, Sabine, Eisenberg, Steven J., El Jabali, Adnan, El Shahawy, Mahfouz, Hernandes, Mauro Esteves, Izal, Ana Etxeberria, Evonich, Rudolph, III, Evseeva, Oksana, Ezhov, Andrey, Fahmy, Raed, Fang, Quan, Farsad, Ramin, Fauchier, Laurent, Favale, Stefano, Fayard, Maxime, Fedele, Jose Luis, Fedele, Francesco, Fedorishina, Olga, Fera, Steven R., Gomes Ferreira, Luis Gustavo, Ferreira, Jorge, Ferri, Claudio, Ferrier, Anna, Ferro, Hugo, Finsen, Alexandra, First, Brian, Fischer, Stuart, Fonseca, Catarina, Almeida, Luísa Fonseca, Forman, Steven, Frandsen, Brad, French, William, Friedman, Keith, Friese, Athena, Fruntelata, Ana Gabriela, Fujii, Shigeru, Fumagalli, Stefano, Fundamenski, Marta, Furukawa, Yutaka, Gabelmann, Matthias, Gabra, Nashwa, Gadsbøll, Niels, Galinier, Michel, Gammelgaard, Anders, Ganeshkumar, Priya, Gans, Christopher, Quintana, Antonio Garcia, Gartenlaub, Olivier, Gaspardone, Achille, Genz, Conrad, Georger, Frédéric, Georges, Jean-Louis, Georgeson, Steven, Giedrimas, Evaldas, Gierba, Mariusz, Ortega, Ignacio Gil, Gillespie, Eve, Giniger, Alberto, Giudici, Michael C., Gkotsis, Alexandros, Glotzer, Taya V., Gmehling, Joachim, Gniot, Jacek, Goethals, Peter, Goldbarg, Seth, Goldberg, Ronald, Goldmann, Britta, Golitsyn, Sergey, Gómez, Silvia, Mesa, Juan Gomez, Gonzalez, Vicente Bertomeu, Gonzalez Hermosillo, Jesus Antonio, González López, Víctor Manuel, Gorka, Hervé, Gornick, Charles, Gorog, Diana, Gottipaty, Venkat, Goube, Pascal, Goudevenos, Ioannis, Graham, Brett, Greer, G. Stephen, Gremmler, Uwe, Grena, Paul G., Grond, Martin, Gronda, Edoardo, Grönefeld, Gerian, Gu, Xiang, Torres Torres, Ivett Guadalupe, Guardigli, Gabriele, Guevara, Carolina, Guignier, Alexandre, Gulizia, Michele, Gumbley, Michael, Günther, Albrecht, Ha, Andrew, Hahalis, Georgios, Hakas, Joseph, Hall, Christian, Han, Bing, Han, Seongwook, Hargrove, Joe, Hargroves, David, Harris, Kenneth B., Haruna, Tetsuya, Hayek, Emil, Healey, Jeff, Hearne, Steven, Heffernan, Michael, Heggelund, Geir, Heijmeriks, J.A., Hemels, Maarten, Hendriks, I., Henein, Sam, Her, Sung-Ho, Hermany, Paul, Hernández Del Río, Jorge Eduardo, Higashino, Yorihiko, Hill, Michael, Hisadome, Tetsuo, Hishida, Eiji, Hoffer, Etienne, Hoghton, Matthew, Hong, Kui, Hong, Suk keun, Horbach, Stevie, Horiuchi, Masataka, Hou, Yinglong, Hsing, Jeff, Huang, Chi-Hung, Huckins, David, Hughes, kathy, Huizinga, A., Hulsman, E.L., Hung, Kuo-Chun, Hwang, Gyo-Seung, Ikpoh, Margaret, Imberti, Davide, Ince, Hüseyin, Indolfi, Ciro, Inoue, Shujiro, Irles, Didier, Iseki, Harukazu, Israel, C. Noah, Iteld, Bruce, Iyer, Venkat, Jackson-Voyzey, Ewart, Jaffrani, Naseem, Jäger, Frank, James, Martin, Jang, Sung-Won, Jaramillo, Nicolas, Jarmukli, Nabil, Jeanfreau, Robert J., Jenkins, Ronald D., Sánchez, Carlos Jerjes, Jimenez, Javier, Jobe, Robert, Joen-Jakobsen, Tomas, Jones, Nicholas, Moura Jorge, Jose Carlos, Jouve, Bernard, Jung, Byung Chun, Jung, Kyung Tae, Jung, Werner, Kachkovskiy, Mikhail, Kafkala, Krystallenia, Kalinina, Larisa, Kallmünzer, Bernd, Kamali, Farzan, Kamo, Takehiro, Kampus, Priit, Kashou, Hisham, Kastrup, Andreas, Katsivas, Apostolos, Kaufman, Elizabeth, Kawai, Kazuya, Kawajiri, Kenji, Kazmierski, John F., Keeling, P., Kerr Saraiva, José Francisco, Ketova, Galina, Khaira, Ajit Singh, Khripun, Aleksey, Kim, Doo-Il, Kim, Young Hoon, Kim, Nam Ho, Kim, Dae Kyeong, Kim, Jeong Su, Kim, June Soo, Kim, Ki Seok, Kim, Jin bae, Kinova, Elena, Klein, Alexander, Kmetzo, James J., Kneller, G. Larsen, Knezevic, Aleksandar, Angela Koh, Su Mei, Koide, Shunichi, Kollias, Anastasios, Kooistra, J.A., Koons, Jay, Koschutnik, Martin, Kostis, William J., Kovacic, Dragan, Kowalczyk, Jacek, Koziolova, Natalya, Kraft, Peter, Kragten, Johannes A., Krantz, Mori, Krause, Lars, Krenning, B.J., Krikke, F., Kromhout, Z., Krysiak, Waldemar, Kumar, Priya, Kümler, Thomas, Kuniss, Malte, Kuo, Jen-Yuan, Küppers, Achim, Karla Kurrelmeyer, Kwak, Choong Hwan, Laboulle, Bénédicte, Labovitz, Arthur, Lai, Wen Ter, Lam, Andy, Lam, Yat Yin, Zanetti, Fernando Lanas, Landau, Charles, Landini, Giancarlo, Figueiredo, Estêvão Lanna, Larsen, Torben, Lavandier, Karine, LeBlanc, Jessica, Lee, Moon Hyoung, Lee, Chang-Hoon, Lehman, John, Leitão, Ana, Lellouche, Nicolas, Lelonek, Malgorzata, Lenarczyk, Radoslaw, Lenderink, T., González, Salvador León, Leong-Sit, Peter, Leschke, Matthias, Ley, Nicolas, Li, Zhanquan, Li, Xiaodong, Li, Weihua, Li, Xiaoming, Lichy, Christhoh, Lieber, Ira, Limon Rodriguez, Ramon Horacio, Lin, Hailong, Lip, Gregory Y.H., Liu, Feng, Liu, Hengliang, Esperon, Guillermo Llamas, Navarro, Nassip Llerena, Lo, Eric, Lokshyn, Sergiy, López, Amador, López-Sendón, José Luís, Lorga Filho, Adalberto Menezes, Lorraine, Richard S., Luengas, Carlos Alberto, Luke, Robert, Luo, Ming, Lupovitch, Steven, Lyrer, Philippe, Ma, Changsheng, Ma, Genshan, Madariaga, Irene, Maeno, Koji, Magnin, Dominique, Maid, Gustavo, Mainigi, Sumeet K., Makaritsis, Konstantinos, Malhotra, Rohit, Manning, Rickey, Manolis, Athanasios, Manrique Hurtado, Helard Andres, Mantas, Ioannis, Jattin, Fernando Manzur, Maqueda, Vicky, Marchionni, Niccolo, Ortuno, Francisco Marin, Santana, Antonio Martín, Martinez, Jorge, Maskova, Petra, Hernandez, Norberto Matadamas, Matsuda, Katsuhiro, Maurer, Tillmann, Mauro, Ciro, May, Erik, Mayer, Nolan, McClure, John, McCormack, Terry, McGarity, William, McIntyre, Hugh, McLaurin, Brent, Medina Palomino, Feliz Alvaro, Melandri, Francesco, Meno, Hiroshi, Menzies, Dhananjai, Mercader, Marco, Meyer, Christian, Meyer, Beat J., Miarka, Jacek, Mibach, Frank, Michalski, Dominik, Michel, Patrik, Chreih, Rami Mihail, Mikdadi, Ghiath, Mikus, Milan, Milicic, Davor, Militaru, Constantin, Minaie, Sedi, Minescu, Bogdan, Mintale, Iveta, Mirault, Tristan, Mirro, Michael J., Mistry, Dinesh, Miu, Nicoleta Violeta, Miyamoto, Naomasa, Moccetti, Tiziano, Mohammed, Akber, Nor, Azlisham Mohd, Mollerus, Michael, Molon, Giulio, Mondillo, Sergio, Moniz, Patrícia, Mont, Lluis, Montagud, Vicente, Montaña, Oscar, Monti, Cristina, Moretti, Luciano, Mori, Kiyoo, Moriarty, Andrew, Morka, Jacek, Moschini, Luigi, Moschos, Nikitas, Mügge, Andreas, Mulhearn, Thomas J., Muresan, Carmen, Muriago, Michela, Musial, Wlodzimierz, Musser, Carl W., Musumeci, Francesco, Nageh, Thuraia, Nakagawa, Hidemitsu, Nakamura, Yuichiro, Nakayama, Toru, Nam, Gi-Byoung, Nanna, Michele, Natarajan, Indira, Nayak, Hemal M., Naydenov, Stefan, Nazlić, Jurica, Cristian Nechita, Alexandru, Nechvatal, Libor, Negron, Sandra Adela, Neiman, James, Neuenschwander, Fernando Carvalho, Neves, David, Neykova, Anna, Miguel, Ricardo Nicolás, Nijmeh, George, Nizov, Alexey, Campos, Rodrigo Noronha, Nossan, Janko, Novikova, Tatiana, Nowalany-Kozielska, Ewa, Nsah, Emmanuel, Nunez Fragoso, Juan Carlos, Nurgalieva, Svetlana, Nuyens, Dieter, Nyvad, Ole, Odin de Los Rios Ibarra, Manuel, O'Donnell, Philip, O'Donnell, Martin, Oh, Seil, Oh, Yong Seog, Oh, Dongjin, O'Hara, Gilles, Oikonomou, Kostas, Olivares, Claudia, Oliver, Richard, Ruiz, Rafael Olvera, Olympios, Christoforos, omaszuk-Kazberuk, Anna, Asensi, Joaquín Osca, Jose, eena Padayattil, Padilla Padilla, Francisco Gerardo, Rios, Victoria Padilla, Pajes, Giuseppe, Pandey, Shekhar, Paparella, Gaetano, Paris, F., Park, Hyung Wook, Park, Jong Sung, Parthenakis, Fragkiskos, Passamonti, Enrico, Patel, Rajesh J., Patel, Jaydutt, Patel, Mehool, Patrick, Janice, Jimenez, Ricardo Pavón, Paz, Analía, Pengo, Vittorio, Pentz, William, Pérez, Beatriz, Pérez Ríos, Alma Minerva, Pérez-Cabezas, Alejandro, Perlman, Richard, Persic, Viktor, Perticone, Francesco, Peters, Terri K., Petkar, Sanjiv, Pezo, Luis Felipe, Pflücke, Christian, Pham, David N., Phillips, Roland T., Phlaum, Stephen, Pieters, Denis, Pineau, Julien, Pinter, Arnold, Pinto, Fausto, Pisters, R., Pivac, Nediljko, Pocanic, Darko, Podoleanu, Cristian, Politano, Alessandro, Poljakovic, Zdravka, Pollock, Stewart, Garcéa, Jose Polo, Poppert, Holger, Porcu, Maurizio, Reino, Antonio Pose, Prasad, Neeraj, Précoma, Dalton Bertolim, Prelle, Alessandro, Prodafikas, John, Protasov, Konstantin, Pye, Maurice, Qiu, Zhaohui, Quedillac, Jean-Michel, Raev, Dimitar, Raffo Grado, Carlos Antonio, Rahimi, Sidiqullah, Raisaro, Arturo, Rama, Bhola, Ramos, Ricardo, Ranieri, Maria, Raposo, Nuno, Rashba, Eric, Rauch-Kroehnert, Ursula, Reddy, Ramakota, Renda, Giulia, Reza, Shabbir, Ria, Luigi, Richter, Dimitrios, Rickli, Hans, Rieker, Werner, Vera, Tomas Ripolil, Ritt, Luiz Eduardo, Roberts, Douglas, Briones, Ignacio Rodriguez, Rodriguez Escudero, Aldo Edwin, Pascual, Carlos Rodríguez, Roman, Mark, Romeo, Francesco, Ronner, E., Roux, Jean-Francois, Rozkova, Nadezda, Rubacek, Miroslav, Rubalcava, Frank, Russo, Andrea M., Rutgers, Matthieu Pierre, Rybak, Karin, Said, Samir, Sakamoto, Tamotsu, Salacata, Abraham, Salem, Adrien, Bodes, Rafael Salguero, Saltzman, Marco A., Salvioni, Alessandro, Vallejo, Gregorio Sanchez, Fernández, Marcelo Sanmartín, Saporito, Wladmir Faustino, Sarikonda, Kesari, Sasaoka, Taishi, Sati, Hamdi, Savelieva, Irina, Scala, Pierre-Jean, Schellinger, Peter, Scherr, Carlos, Schmitz, Lisa, Schmitz, Karl-Heinz, Schmitz, Bettina, Schnabel, Teresa, Schnupp, Steffen, Schoeniger, Peter, Schön, Norbert, Schwimmbeck, Peter, Seamark, Clare, Searles, Greg, Seidl, Karl-Heinz, Seidman, Barry, Sek, Jaroslaw, Sekaran, Lakshmanan, Serrati, Carlo, Shah, Neerav, Shah, Vinay, Shah, Anil, Shah, Shujahat, Sharma, Vijay Kumar, Shaw, Louise, Sheikh, Khalid H., Shimizu, Naruhito, Shimomura, Hideki, Shin, Dong-Gu, Shin, Eun-Seok, Shite, Junya, Sibilio, Gerolamo, Silver, Frank, Sime, Iveta, Simmers, Tim A., Singh, Narendra, Siostrzonek, Peter, Smadja, Didier, Smith, David W., Snitman, Marcelo, Filho, Dario Sobral, Soda, Hassan, Sofley, Carl, Sokal, Adam, Oi Yan, Yannie Soo, Sotolongo, Rodolfo, Ferreira de Souza, Olga, Sparby, Jon Arne, Spinar, Jindrich, Sprigings, David, Spyropoulos, Alex C., Stakos, Dimitrios, Steinwender, Clemens, Stergiou, Georgios, Stiell, Ian, Stoddard, Marcus, Stoikov, Anastas, Streb, Witold, Styliadis, Ioannis, Su, Guohai, Su, Xi, Sudnik, Wanda, Sukles, Kai, Sun, Xiaofei, Swart, H., Szavits-Nossan, Janko, Taggeselle, Jens, Takagi, Yuichiro, Singh Takhar, Amrit Pal, Tamm, Angelika, Tanaka, Katsumi, Tanawuttiwat, Tanyanan, Tang, Sherman, Tang, Aylmer, Tarsi, Giovanni, Tassinari, Tiziana, Tayal, Ashis, Tayebjee, Muzahir, Berg, J.M. ten, Tesloianu, Dan, The, Salem H.K., Thomas, Dierk, Timsit, Serge, Tobaru, Tetsuya, Tomasik, Andrzej R., Torosoff, Mikhail, Touze, Emmanuel, Trendafilova, Elina, Tsai, W. Kevin, Tse, Hung Fat, Tsutsui, Hiroshi, Tu, Tian Ming, Tuininga, Ype, Turakhia, Minang, Turk, Samir, Turner, Wayne, Tveit, Arnljot, Tytus, Richard, Valadão, C., van Bergen, P.F.M.M., van de Borne, Philippe, van den Berg, B.J., van der Zwaan, C., Van Eck, M., Vanacker, Peter, Vasilev, Dimo, Vasilikos, Vasileios, Vasilyev, Maxim, Veerareddy, Srikar, Miño; Asok Venkataraman, Mario Vega, Verdecchia, Paolo, Versaci, Francesco, Vester, Ernst Günter, Vial, Hubert, Victory, Jason, Villamil, Alejandro, Vincent, Marc, Vlastaris, Anthony, Dahl, Jürgen vom, Vora, Kishor, Vranian, Robert B., Wakefield, Paul, Wang, Ningfu, Wang, Mingsheng, Wang, Xinhua, Wang, Feng, Wang, Tian, Warner, Alberta L., Watanabe, Kouki, Wei, Jeanne, Weimar, Christian, Weiner, Stanislav, Weinrich, Renate, Wen, Ming-Shien, Wiemer, Marcus, Wiggers, Preben, Wilke, Andreas, Williams, David, Williams, Marcus L., Witzenbichler, Bernhard, Wong, Brian, Lawrence Wong, Ka Sing, Wozakowska-Kaplon, Beata, Wu, Shulin, Wu, Richard C., Wunderlich, Silke, Wyatt, Nell, Wylie, John (Jack), Xu, Yong, Xu, Xiangdong, Yamanoue, Hiroki, Yamashita, Takeshi, Bryan Yan, Ping Yen, Yang, Tianlun, Yao, Jing, Yeh, Kuo-Ho, Yin, Wei Hsian, Yotov, Yoto, Zahn, Ralf, Zarich, Stuart, Zenin, Sergei, Zeuthen, Elisabeth Louise, Zhang, Huanyi, Zhang, Donghui, Zhang, Xingwei, Zhang, Ping, Zhang, Jun, Zhao, Shui Ping, Zhao, Yujie, Zhao, Zhichen, Zheng, Yang, Zhou, Jing, Zimmermann, Sergio, Zini, Andrea, Zizzo, Steven, Zong, Wenxia, Zukerman, L. Steven, Romiti, Giulio Francesco, Corica, Bernadette, Proietti, Marco, Mei, Davide Antonio, Frydenlund, Juliane, Bisson, Arnaud, Olshansky, Brian, Chan, Yi-Hsin, Huisman, Menno V., and Chao, Tze-Fan
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- 2023
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131. The multi-societal European consensus on the terminology, diagnosis and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE
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Hauke Lang, Smith, Martin, deOliveira, Michelle L., Adair, Anya, Gilg, Stefan, Swijnenburg, Rutger-Jan, Jaekers, Joris, Jegatheeswaran, Santhalingam, Buis, Carlijn, Parks, Rowan, Bockhorn, Maximilian, Conroy, Thierry, Petras, Panagiotis, Primavesi, Florian, Chan, Anthony K.C., Cipriani, Federica, Rubbia-Brandt, Laura, Foster, Lucy, Abdelaal, Amr, Yaqub, Sheraz, Rahbari, Nuh, Fondevila, Constantino, Abradelo, Manuel, Kok, Niels FM., Tejedor, Luis, Martinez-Baena, Dario, Azoulay, Daniel, Maglione, Manuel, Serradilla-Martín, Mario, Azevedo, José, Romano, Fabrizio, Line, Pål-Dag, Forcén, Teresa Abadía, Panis, Yves, Stylianides, Nicolas, Bale, Reto, Quaia, Emilio, Yassin, Nuha, Duque, Victoria, Espin-Basany, Eloy, Mellenhorst, Jarno, Rees, Adam, Adeyeye, Ademola, Tuynman, Jurriaan B., Simillis, Constantinos, Duff, Sarah, Wilson, Richard, De Nardi, Paola, Palmer, Gabriella Jansson, Zakaria, Andee Dzulkarnaen, Perra, Teresa, Porcu, Alberto, Tamini, Nicolò, Kelly, Michael E., Metwally, Islam, Morarasu, Stefan, Carbone, Fabio, Estaire-Gómez, Mercedes, Perez, Elena Martin, Seligmann, Jennifer, Gollins, Simon, Braun, Michael, Hessheimer, Amelia, Alonso, Vincente, Radhakrishna, Ganesh, Alam, Noreen, Camposorias, Constantinos, Barriuoso, Jorge, Ross, Paul, Ba-Ssalamah, Ahmed, Muthu, Sivakumar, Filobbos, Rafik, Nadarajah, Vinotha, Hattab, Annas, Newton, Claire, Barker, Sharon, Sibbald, Jill, Hancock, Jodie, de Liguori Carino, Nicola, Deshpande, Rahul, Lancellotti, Francesco, Paterna, Sandra, Gutierrez-Diez, Marta, Artigas, Consuelo, Siriwardena, Ajith K., Serrablo, Alejandro, Fretland, Åsmund A., Wigmore, Stephen J., Ramia-Angel, Jose M., Malik, Hassan Z., Stättner, Stefan, Søreide, Kjetil, Zmora, Oded, Meijerink, Martijn, Kartalis, Nikolaos, Lesurtel, Mickaël, Verhoef, Cornelis, Balakrishnan, Anita, Gruenberger, Thomas, Jonas, Eduard, Devar, John, Jamdar, Saurabh, Jones, Robert, Hilal, Mohammad A., Andersson, Bodil, Boudjema, Karim, Mullamitha, Saifee, Stassen, Laurents, Dasari, Bobby V.M., Frampton, Adam E., Aldrighetti, Luca, Pellino, Gianluca, Buchwald, Pamela, Gürses, Bengi, Wasserberg, Nir, Gruenberger, Birgit, Spiers, Harry V.M., Jarnagin, William, Vauthey, Jean-Nicholas, Kokudo, Norihiro, Tejpar, Sabine, Valdivieso, Andres, and Adam, René
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- 2023
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132. Epidemiology and Burden of Influenza in Children 0–14 Years Over Ten Consecutive Seasons in Italy
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Barbieri, Elisa, Porcu, Gloria, Donà, Daniele, Cavagnis, Sara, Cantarutti, Luigi, Scamarcia, Antonio, McGovern, Ian, Haag, Mendel, Giaquinto, Carlo, and Cantarutti, Anna
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- 2023
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133. Development of a methodology for evaluating spaceborne W-band Doppler radar by combined use of Micro Rain Radar and a disdrometer in Antarctica
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Bracci, Alessandro, Sato, Kaori, Baldini, Luca, Porcù, Federico, and Okamoto, Hajime
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- 2023
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134. Preclinical in vivo antitumor activity experiments : methodological pitfalls and a new framework for their design and analysis
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Porcu, Luca
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616.99 - Abstract
Aims: Poorly designed, analyzed and reported preclinical in vivo experiments (inVivoExp) raise ethical as well as scientific concerns. It could be hypothesized that the recurring failure of apparently promising interventions to improve outcome in clinical trials has been partially caused by poor quality of statistical design and analysis (QoStat) of inVivoExp. This project aimed to assess and correlate QoStat with clinical activity, and to improve the statistical framework used in inVivoExp. Methods: A systematic search of Medline and EMBASE databases was carried out to identify epithelial ovarian cancer clinical trials assessing the antitumor activity of candidate compounds (CC) as monotherapy. For each eligible CC, a systematic search was carried out to identify scientific papers reporting inVivoExp on rats and mice, in which the CC was administered as monotherapy. An ad hoc checklist was used to assess QoStat of inVivoExp. QoStat was correlated to the clinical activity. Results: Fifty-two eligible CCs and 121 inVivoExp were identified. In 45 out of 120 (37.5%) inVivoExp the method of treatment assignment was not specified. The randomization type was specified in 3 out of 74 (4.1%) inVivoExp and sample size was justified in 9 (7.4%) inVivoExp. If the primary outcome was tumor volume, the antitumor activity endpoint was declared in 14 out of 106 (13.2%) inVivoExp. The length of follow-up was specified in 43 (35.5%) inVivoExp. Outcome assessor was blinded in 5 (4.1%) inVivoExp. Inefficient statistical methods were often applied to analyze tumor growth data. A new statistical framework based on the Mann-Whitney statistic was proposed and applied to a specific tumor model. Conclusions: QoStat of inVivoExp was so poor that the correlation with clinical activity was impossible. The magnitude of the biological signal was poorly estimated. The new statistical framework should be considered for the design and analysis of in vivo tumor growth studies.
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- 2020
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135. Systemic hemostatic agents initiated in trauma patients in the pre-hospital setting: a systematic review
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Biffi, Annalisa, Porcu, Gloria, Castellini, Greta, Napoletano, Antonello, Coclite, Daniela, D’Angelo, Daniela, Fauci, Alice Josephine, Iacorossi, Laura, Latina, Roberto, Salomone, Katia, Iannone, Primiano, Gianola, Silvia, and Chiara, Osvaldo
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- 2022
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136. Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia
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Laurila, Pirkka-Pekka, Wohlwend, Martin, Imamura de Lima, Tanes, Luan, Peiling, Herzig, Sébastien, Zanou, Nadège, Crisol, Barbara, Bou-Sleiman, Maroun, Porcu, Eleonora, Gallart-Ayala, Hector, Handzlik, Michal K., Wang, Qi, Jain, Suresh, D’Amico, Davide, Salonen, Minna, Metallo, Christian M., Kutalik, Zoltan, Eichmann, Thomas O., Place, Nicolas, Ivanisevic, Julijana, Lahti, Jari, Eriksson, Johan G., and Auwerx, Johan
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- 2022
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137. Multivariate Kalman filtering for spatio-temporal processes
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Ferreira, Guillermo, Mateu, Jorge, and Porcu, Emilio
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- 2022
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138. Outcomes of two-step haploidentical allogeneic stem cell transplantation in elderly patients with hematologic malignancies
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Bi, Xia, Gergis, Usama, Wagner, John L., Carabasi, Matthew, Filicko-O’Hara, Joanne, O’Hara, William, Klumpp, Thomas, Porcu, Pierluigi, Flomenberg, Neal, and Grosso, Dolores
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- 2022
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139. Estimating All-Cause Deaths Averted in the First Two Years of the COVID-19 Vaccination Campaign in Italy
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Giovanni Corrao, Gloria Porcu, Alina Tratsevich, Danilo Cereda, Giovanni Pavesi, Guido Bertolaso, and Matteo Franchi
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COVID-19 ,vaccination ,public health ,epidemiology ,excess all-cause deaths ,SARIMAX ,Medicine - Abstract
Comparing deaths averted by vaccination campaigns is a crucial public health endeavour. Excess all-cause deaths better reflect the impact of the pandemic than COVID-19 deaths. We used a seasonal autoregressive integrated moving average with exogenous factors model to regress daily all-cause deaths on annual trend, seasonality, and environmental temperature in three Italian regions (Lombardy, Marche and Sicily) from 2015 to 2019. The model was used to forecast excess deaths during the vaccinal period (December 2020–October 2022). We used the prevented fraction to estimate excess deaths observed during the vaccinal campaigns, those which would have occurred without vaccination, and those averted by the campaigns. At the end of the vaccinal period, the Lombardy region proceeded with a more intensive COVID-19 vaccination campaign than other regions (on average, 1.82 doses per resident, versus 1.67 and 1.56 in Marche and Sicily, respectively). A higher prevented fraction of all-cause deaths was consistently found in Lombardy (65% avoided deaths, as opposed to 60% and 58% in Marche and Sicily). Nevertheless, because of a lower excess mortality rate found in Lombardy compared to Marche and Sicily (12, 24 and 23 per 10,000 person-years, respectively), a lower rate of averted deaths was observed (22 avoided deaths per 10,000 person-years, versus 36 and 32 in Marche and Sicily). In Lombardy, early and full implementation of adult COVID-19 vaccination was associated with the largest reduction in all-cause deaths compared to Marche and Sicily.
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- 2024
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140. Collaborative Monitoring of Plant Biodiversity and Research on Sweet Acorn Oaks within Paths of Knowledge and Sustainability Education
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Antonino Soddu Pirellas, Mauro Ballero, Sebastiano Porcu, Giovanna Serra, Francesco Sanna, and Michele Puxeddu
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plant biodiversity ,rural communities ,Quercus ilex ,habitat ,Mediterranean diet ,landscape enjoyment ,Environmental technology. Sanitary engineering ,TD1-1066 - Abstract
Numerous studies have shown the multiple benefits of plant biodiversity and the crucial role of residents’ awareness of conservation and land management. Plant biodiversity was investigated in an analytical monitoring report conducted jointly with the local population engaged in livestock activities and young residents who were shifting toward hospitality and tourism. The study area, covering over 800 km2 in Sardinia, is half forested and attracts interest in its landscape. During our research, genotypes of Quercus ilex L., with sweet acorns rich in polyphenols, as the oldest ecosystem services in these rural communities, were discovered. Collaborative monitoring focused attention on the benefits of plants in different habitats as follows: 53% were known to livestock farmers as food for local breeds of goats and pigs, 15% were official, and 13% were endemic. They had also been used for human nutrition within the Mediterranean diet and attracted interest for their use in landscapes and gardens. This study analyzes numerical data from critical and educational perspectives. These data serve as indicators of ecosystem health for the purpose of sustainable management policies and attest to collaborative monitoring as a tool for analyzing human activities and the necessary balance between profit and biodiversity conservation, given the current challenging climate change conditions.
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- 2024
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141. The Extreme Rainfall Events of the 2020 Typhoon Season in Vietnam as Seen by Seven Different Precipitation Products
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Giacomo Roversi, Marco Pancaldi, William Cossich, Daniele Corradini, Thanh Thi Nhat Nguyen, Thu Vinh Nguyen, and Federico Porcu’
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Vietnam ,precipitation ,satellite ,rain gauge ,AWS ,weather radar ,Science - Abstract
A series of typhoons and tropical storms have produced extreme precipitation events in Vietnam during the first part of the 2020 monsoon season: events of this magnitude pose significant challenges to remote sensing Quantitative Precipitation Estimation (QPE) techniques. The weather-monitoring needs of modern human activities require that these challenges be overcome. In order to address this issue, in this work, seven precipitation products were validated with high spatial and temporal detail against over 1200 rain gauges in Vietnam during six case studies tailored around the most intense events of 2020. The data sources included the Vietnamese weather radar network, IMERG Early run and Final run, the South Korean GEO-KOMPSAT-2A and Chinese FengYun-4A geostationary satellites, DPR on board the GPM-Core Observatory, and European ERA5-Land reanalysis. All products were resampled to a standardized 0.02° grid and compared at hourly scale with ground stations measurements. The results indicated that the radars product was the most capable of reproducing the information collected by the rain gauges during the selected extreme events, with a correlation coefficient of 0.70 and a coefficient of variation of 1.38. However, it exhibited some underestimation, approximately 30%, in both occurrence and intensity. Conversely, geostationary products tended to overestimate moderate rain rates (FY-4A) and areas with low precipitation (GK-2A). More complex products such as ERA5-Land and IMERG failed to capture the highest intensities typical of extreme events, while GPM-DPR showed promising results in detecting the highest rain rates, but its capability to observe isolated events was limited by its intermittent coverage.
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- 2024
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142. Recalcitrant Cutaneous Mastocytosis Treated With Genetically Informed Targeted Therapy: A Case Report
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Laura Gleason, Volkan Tekmen, Alexa Cohen, Safiyyah Bhatti, Burcu Beksac, Jisun Cha, Pierluigi Porcu, and Neda Nikbakht
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Dermatology ,RL1-803 - Abstract
Introduction:. Mastocytosis, a clonal proliferation of mast cells commonly involving the skin and bone marrow, has a varied clinical presentation ranging from cutaneous lesions to systemic disease. Cutaneous mastocytosis is managed symptomatically, but systemic mastocytosis is treated with targeted therapy against the mutated receptor tyrosine kinase c-KIT, the pathogenic driver of mastocytosis. However, there are no guidelines for the treatment of cutaneous mastocytosis refractory to symptomatic management. We herein report a method to select genetically informed therapy for symptomatic and recalcitrant cutaneous mastocytosis. Case presentation:. We performed a mutational analysis of dermal mast cells after enrichment by laser capture in a 23-year-old woman with recalcitrant cutaneous mastocytosis. The analysis revealed a aspartic acid to valine substitution at codon 816 (D816V) mutation in the protein c-KIT. Based on these results, we initiated treatment with the multi-kinase/KIT inhibitor midostaurin, a treatment effective against the D816V c-KIT mutation. After 3 months of treatment, the patient exhibited a reduction in the number and size of cutaneous lesions and reported resolution of pruritus and decreased severity of other mast cell-related symptoms. Discussion:. The treatment of mastocytosis relies heavily on whether the disease is limited to the skin or systemic. However, there are no guidelines for cutaneous mastocytosis that does not respond to symptomatic management. In the present report describing a patient with recalcitrant cutaneous mastocytosis, we describe a strategy in which skin mutational analysis is used to guide the selection of targeted therapy. Conclusion:. Performing mast cell mutational analyses in the skin provides a means to select targeted therapy for symptomatic and refractory cutaneous mastocytosis.
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- 2023
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143. SAFETY AND EFFICACY FINDINGS OF A PHASE 1B/2 STUDY OF NANATINOSTAT PLUS VALGANCICLOVIR FOR TREATMENT OF RELAPSED/REFRACTORY EPSTEIN-BARR VIRUS-POSITIVE DIFFUSE LARGE B-CELL LYMPHOMA
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M Capra, P Scheinberg, J Pereira, B Haverkos, S Spruill, D Strickland, and P Porcu
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Background: Diffuse large B-cell lymphoma (DLBCL) is one of several lymphoid malignancies in which Epstein-Barr virus (EBV) can play a significant role in pathogenesis. An estimated 5–14% of DLBCL cases are linked to EBV, which is associated with poor prognosis and 5-year survival rates as low as 25%. EBV is an attractive and druggable, but largely untapped, non-host tumor target, partly due to its latency. Most EBV genes, including those of the lytic cycle, are epigenetically silenced, preventing effective viral targeting. However, reactivation of viral gene expression with a histone deacetylase inhibitor (HDACi), combined with a DNA synthesis inhibitor, such as ganciclovir and its oral prodrug valganciclovir (VGCV), is an effective strategy to induce EBV+ tumor cell apoptosis. The safety and efficacy of this novel therapeutic strategy was investigated here using the HDACi nanatinostat (Nstat) and VGCV in patients (pts) with EBV-positive (EBV+) DLBCL. Methods: This Phase 1b/2 study (NCT03397706) assessed Nstat+VGCV in pts aged ≥18 years with EBV+ relapsed/refractory lymphoid malignancies. For inclusion, pts must have had ≥1 prior systemic therapies and no viable curative treatment options. Phase 1b evaluated safety and defined the recommended Phase 2 dose of Nstat+VGCV. Safety was assessed from first drug administration until 28 days post-last dose or until the start of a new anticancer therapy. Phase 2 assessed efficacy (overall response rate [ORR]). Here, subgroup analysis data of pts with DLBCL are reported. Results: Ten pts with DLBCL were included in the Safety Analysis Set. The median age was 76 years, 70% of pts were male and 80% had stage 3–4 disease. At the data cut-off (May 4, 2023), all pts had reported ≥1 treatment-emergent adverse event (TEAE). The most common any-grade TEAEs were fatigue (n = 8, 80%), neutropenia (n = 6, 60%), anemia, and decreased platelet count/thrombocytopenia (both n = 5, 50%). The most common grade ≥3 TEAEs were neutropenia (n = 5, 50%), anemia (n = 3, 30%), and decreased white blood cell/lymphocyte count (n = 2, 20%). The most common any-grade TEAEs related to the study drugs were fatigue, neutropenia (both n = 6, 60%), anemia, and decreased platelet count/thrombocytopenia (both n = 4, 40%). Five pts (50%) reported ≥1 serious TEAE. Four pts (40%) experienced study drug-related serious adverse reactions, namely atrial fibrillation (n = 2, 20%), febrile neutropenia, and myelodysplastic syndrome (both n = 1, 10%). No deaths due to events related to the study drugs were reported. Nine pts were evaluable for efficacy (1 excluded due to an unrelated serious adverse event). Three pts (33.3%) had a complete response (CR) and 3 (33.3%) had a partial response (PR); 1 pt (11%) had stable disease (SD). The ORR was 66.7%, with a 77.8% disease control rate (CR+PR+SD). At data cut-off, the duration of response (DoR) was not evaluable, as 3 pts remained on study treatment with DoR values of 11.2 (CR), 42.5 (PR) and 49.7 (CR) months. Conclusions: Encouraging safety and efficacy findings were observed with Nstat+VGCV in DLBCL, with durable disease control in responders. Hematologic toxicities were consistent with the VGCV safety profile. An ongoing confirmatory Phase 2 study (NCT05011058) will provide further data on this novel treatment combination for EBV+ lymphomas. Editorial support for this abstract was funded by Viracta.
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- 2023
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144. A PHASE 1B/2 STUDY EVALUATING THE SAFETY AND EFFICACY OF NANATINOSTAT PLUS VALGANCICLOVIR FOR TREATMENT OF RELAPSED/REFRACTORY EPSTEIN-BARR VIRUS-POSITIVE NODAL PERIPHERAL T-CELL LYMPHOMA
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J Pereira, P Scheinberg, M Capra, P Porcu, S Spruill, D Strickland, and B Haverkos
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Background: Around 40% of peripheral T-cell lymphomas (PTCL) are linked to Epstein-Barr virus (EBV), which is associated with poor prognosis and 5-year overall survival rates as low as 20%. EBV is latent in tumors: most viral genes, bar those driving host cell growth and apoptosis blockade, are silenced. However, novel therapeutics aim to target EBV-positive (EBV+) tumors by reinstating viral gene expression to activate the nucleoside analogue ganciclovir (GCV) that inhibits viral and tumor DNA synthesis and prompts cell death. The safety and efficacy of this strategy was evaluated here with the histone deacetylase inhibitor nanatinostat (Nstat) and the oral pro-drug of GCV, valganciclovir (VGCV), in patients (pts) with EBV+ PTCL. Methods: This Phase 1b/2 study (NCT03397706) assessed Nstat+VGCV in pts aged ≥18 years with EBV+ relapsed/refractory lymphoid malignancies who had ≥1 prior systemic therapy and no viable curative treatment options. EBV status was determined by the site or central laboratory on a specimen representative of the current disease. Phase 1b evaluated safety (from first drug administration until 28 days post-last dose or until the start of a new anticancer therapy) and established the recommended Phase 2 dose. Phase 2 assessed efficacy (overall response rate [ORR]). Here, subgroup analysis data from pts with PTCL (angioimmunoblastic T-cell lymphoma [AITL] and PTCL not otherwise specified [PTCL-NOS]), are reported. Results: Thirteen patients with nodal PTCL (8 AITL, 5 PTCL-NOS) were enrolled. The median age was 68.4 years, 69% were male, and 92% had stage 3–4 disease. At data cut-off (May 4, 2023), all pts had ≥1 treatment-emergent adverse event (TEAE). The most common (reported in ≥10% of pts) any-grade TEAEs were decreased white blood cell (WBC)/lymphocyte count (n = 6, 46%), fatigue and diarrhea (both n = 5, 38%) (Table 1). Grade ≥3 TEAEs included decreased WBC/lymphocyte count (n = 4, 31%) and decreased neutrophil count (n = 3, 23%). The most common any-grade, study drug-related TEAEs were nausea and increased blood creatine (both n = 4, 31%); anemia, fatigue, diarrhea, decreased neutrophil count, decreased appetite and decreased WBC/lymphocyte count were the next most common (all n = 3, 23%). Of the most common study drug-related TEAEs, most (76%) were grade 1/2. Three pts had ≥1 serious TEAE, including infection, gastrointestinal disorders and new neoplasm. No serious adverse reactions or deaths due to events related to the study drugs were reported. Eight pts were evaluable for efficacy (5 pts non-evaluable due to TEAEs [ n = 3], investigator decision [ n = 1] and EBV− status [ n = 1]). Three pts (37.5%) had complete responses (CR), 1 (12.5%) had a partial response (PR), 1 had stable disease (SD) and 3 had progressive disease. The ORR was 50%, with a 62.5% disease control rate (DCR [CR+PR+SD]). The median duration of response (DoR) was 17.3 months (mos). ORR and DCR were similar in AITL and PTCL-NOS, but DoR was longer in pts with AITL (n = 2, 38.3 mos) compared with PTCL-NOS (n = 2, 6.1 mos). Conclusions: Encouraging safety and efficacy findings were observed with Nstat+VGCV in PTCL. Hematologic toxicities were consistent with the VGCV safety profile. An ongoing Phase 2 study (NCT05011058) will provide further data on this novel therapy for EBV+ lymphomas. Editorial support for this abstract was funded by Viracta.
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- 2023
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145. Hepatitis B Virus and B-cell lymphoma: evidence, unmet need, clinical impact, and opportunities
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Maya Rosenberg, Maria Poluch, Colin Thomas, Paola Sindaco, Alan Khoo, and Pierluigi Porcu
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hepatitis B ,B-cell ,lymphoma ,DLBCL ,double hit ,viral oncogenesis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Nearly a billion people worldwide are infected with the hepatitis B Virus (HBV) and about a third of them have chronic infection. HBV is an important cause of morbidity and mortality, including acute and chronic hepatitis and hepatocellular carcinoma (HCC). Screening and control of primary HBV infection through vaccination represent a major advance in global public health, but large sections of the world population, in both developed and underdeveloped countries, remain unscreened and unvaccinated. In addition to being a global cause of liver disease, an important role of HBV in lymphoma has also emerged. First, the high risk of HBV reactivation in previously infected patients receiving chemo-immunotherapy necessitates the systematic evaluation of HBV serological status in all non-Hodgkin’s lymphoma (NHL) cases and preemptive antiviral therapy for those who may have chronic or occult HBV infection. Second, HBV has been shown to infect lymphocytes, namely B-cells, and has been associated with a higher risk of developing B-cell lymphoma, most clearly in countries where HBV is endemic. While the risk of HBV reactivation with chemoimmunotherapy in NHL is well known, the role and the impact of HBV as a global lymphoma risk factor and potential oncogenic driver in B-cells are very poorly understood. Here, we review the clinical and scientific evidence supporting an association between HBV and B-cell lymphoma, with a particular focus on diffuse large B-cell lymphoma (DLBCL) and provide an overview of the estimated impact of HBV infection on the biology and clinical course of DLBCL. We also discuss ways to gain a better insight into the unmet need posed by HBV in lymphoma and whether assessing immune responses to HBV, measuring viral loads, and detecting the presence of HBV-encoded proteins in tumor tissue could be integrated into the molecular and clinical risk stratification of patients with DLBCL.
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- 2023
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146. Communal nesting differentially attenuates the impact of pre-weaning social isolation on behavior in male and female rats during adolescence and adulthood
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Jessica Bratzu, Maria Ciscato, Augusta Pisanu, Giuseppe Talani, Roberto Frau, Patrizia Porcu, Marco Diana, Fabio Fumagalli, Patrizia Romualdi, Laura Rullo, Viviana Trezza, Roberto Ciccocioppo, Fabrizio Sanna, and Liana Fattore
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early-life stress ,social enrichment ,isolation ,communal nesting ,anxiety-like behaviors ,marble-burying ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
IntroductionEarly social isolation (ESI) disrupts neurodevelopmental processes, potentially leading to long-lasting emotional and cognitive changes in adulthood. Communal nesting (CN), i.e., the sharing of parental responsibilities between multiple individuals in a nest, creates a socially enriching environment known to impact social and anxiety-related behaviors.MethodsThis study examines the effects of (i) the CN condition and of (ii) ESI during the 3rd week of life (i.e., pre-weaning ESI) on motor, cognitive, and emotional domains during adolescence and adulthood in male and female rats reared in the two different housing conditions, as well as (iii) the potential of CN to mitigate the impact of ESI on offspring.ResultsWe found that in a spontaneous locomotor activity test, females exhibited higher activity levels compared to males. In female groups, adolescents reared in standard housing (SH) condition spent less time in the center of the arena, suggestive of increased anxiety levels, while the CN condition increased the time spent in the center during adolescence, but not adulthood, independently from ESI. The prepulse inhibition (PPI) test showed a reduced PPI in ESI adolescent animals of both sexes and in adult males (but not in adult females), with CN restoring PPI in males, but not in adolescent females. Further, in the marble burying test SH-ESI adolescent males exhibited higher marble burying behavior than all other groups, suggestive of obsessive-compulsive traits. CN completely reversed this stress-induced effect. Interestingly, ESI and CN did not have a significant impact on burying behavior in adult animals of both sexes.DiscussionOverall, our findings (i) assess the effects of ESI on locomotion, sensorimotor gating, and compulsive-like behaviors, (ii) reveal distinct vulnerabilities of males and females within these domains, and (iii) show how early-life social enrichment may successfully counteract some of the behavioral alterations induced by early-life social stress in a sex-dependent manner. This study strengthens the notion that social experiences during early-life can shape emotional and cognitive outcomes in adulthood, and points to the importance of social enrichment interventions for mitigating the negative effects of early social stress on neurodevelopment.
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- 2023
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147. What is the ideal endpoint in early-stage immunotherapy neoadjuvant trials in lung cancer?
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Robert B. Cameron, Jacobi B. Hines, Valter Torri, Luca Porcu, Jessica Donington, Christine M. Bestvina, Everett Vokes, James M. Dolezal, Alessandra Esposito, and Marina C. Garassino
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Numerous clinical trials investigating neoadjuvant immune checkpoint inhibitors (ICI) have been performed over the last 5 years. As the number of neoadjuvant trials increases, attention must be paid to identifying informative trial endpoints. Complete pathologic response has been shown to be an appropriate surrogate endpoint for clinical outcomes, such as event-free survival or overall survival, in breast cancer and bladder cancer, but it is less established for non-small-cell lung cancer (NSCLC). The simultaneous advances reported with adjuvant ICI make the optimal strategy for early-stage disease debatable. Considering the long time required to conduct trials, it is important to identify optimal endpoints and discover surrogate endpoints for survival that can help guide ongoing clinical research. Endpoints can be grouped into two categories: medical and surgical. Medical endpoints are measures of survival and drug activity; surgical endpoints describe the feasibility of neoadjuvant approaches at a surgical level as well as perioperative attrition and complications. There are also several exploratory endpoints, including circulating tumor DNA clearance and radiomics. In this review, we outline the advantages and disadvantages of commonly reported endpoints for clinical trials of neoadjuvant regimens in NSCLC.
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- 2023
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148. Genome-wide Association Studies of Retinal Vessel Tortuosity Identify Numerous Novel Loci Revealing Genes and Pathways Associated With Ocular and Cardiometabolic Diseases
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Mattia Tomasoni, PhD, Michael Johannes Beyeler, MSc, Sofia Ortin Vela, MSc, Ninon Mounier, PhD, Eleonora Porcu, PhD, Tanguy Corre, PhD, Daniel Krefl, PhD, Alexander Luke Button, PhD, Hana Abouzeid, MD, Konstantinidis Lazaros, MD, Murielle Bochud, MD, PhD, Reinier Schlingemann, MD, PhD, Ciara Bergin, PhD, and Sven Bergmann, PhD
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GWAS ,Retina ,Microvasculature ,Tortuosity ,Mendelian randomization ,Ophthalmology ,RE1-994 - Abstract
Purpose: To identify novel susceptibility loci for retinal vascular tortuosity, to better understand the molecular mechanisms modulating this trait, and reveal causal relationships with diseases and their risk factors. Design: Genome-wide Association Studies (GWAS) of vascular tortuosity of retinal arteries and veins followed by replication meta-analysis and Mendelian randomization (MR). Participants: We analyzed 116 639 fundus images of suitable quality from 63 662 participants from 3 cohorts, namely the UK Biobank (n = 62 751), the Swiss Kidney Project on Genes in Hypertension (n = 397), and OphtalmoLaus (n = 512). Methods: Using a fully automated retina image processing pipeline to annotate vessels and a deep learning algorithm to determine the vessel type, we computed the median arterial, venous and combined vessel tortuosity measured by the distance factor (the length of a vessel segment over its chord length), as well as by 6 alternative measures that integrate over vessel curvature. We then performed the largest GWAS of these traits to date and assessed gene set enrichment using the novel high-precision statistical method PascalX. Main Outcome Measure: We evaluated the genetic association of retinal tortuosity, measured by the distance factor. Results: Higher retinal tortuosity was significantly associated with higher incidence of angina, myocardial infarction, stroke, deep vein thrombosis, and hypertension. We identified 175 significantly associated genetic loci in the UK Biobank; 173 of these were novel and 4 replicated in our second, much smaller, metacohort. We estimated heritability at ∼25% using linkage disequilibrium score regression. Vessel type specific GWAS revealed 116 loci for arteries and 63 for veins. Genes with significant association signals included COL4A2, ACTN4, LGALS4, LGALS7, LGALS7B, TNS1, MAP4K1, EIF3K, CAPN12, ECH1, and SYNPO2. These tortuosity genes were overexpressed in arteries and heart muscle and linked to pathways related to the structural properties of the vasculature. We demonstrated that retinal tortuosity loci served pleiotropic functions as cardiometabolic disease variants and risk factors. Concordantly, MR revealed causal effects between tortuosity, body mass index, and low-density lipoprotein. Conclusions: Several alleles associated with retinal vessel tortuosity suggest a common genetic architecture of this trait with ocular diseases (glaucoma, myopia), cardiovascular diseases, and metabolic syndrome. Our results shed new light on the genetics of vascular diseases and their pathomechanisms and highlight how GWASs and heritability can be used to improve phenotype extraction from high-dimensional data, such as images. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
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- 2023
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149. Minimax Density Estimation on Sobolev Spaces With Dominating Mixed Smoothness
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Cleanthous, Galatia, Georgiadis, Athanasios G., and Porcu, Emilio
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Mathematics - Statistics Theory ,Mathematics - Probability ,62G07 - Abstract
We study minimax density estimation on the product space $\mathbb{R}^{d_1}\times\mathbb{R}^{d_2}$. We consider $L^p$-risk for probability density functions defined over regularity spaces that allow for different level of smoothness in each of the variables. Precisely, we study probabilities on Sobolev spaces with dominating mixed-smoothness. We provide the rate of convergence that is optimal even for the classical Sobolev spaces., Comment: 29 pages, 2 figures
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- 2019
150. Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study
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Aroori, Somaiah, Labib, Peter L., Russell, Thomas B., Streeter, Adam, Denson, Jemimah, Puckett, Mark, Browning, Matthew G., Ausania, Fabio, González-Abós, Carolina, Pando, Elizabeth, Fernandes, Nair, Moller, Elsa G., Taboada, Cristina D., Roberts, Keith J., Pande, Rupaly, Alfarah, Jameel, Kausar, Ambareen, Bandyopadhyay, Samik, Abdelrahim, Ahmed, Khan, Ayesha, Mavroeidis, Vasileios K., Jordan, Caitlin, Rees, Jonathan R.E., Marangoni, Gabriele, Blege, Collaborator: Harry, Thomasset, Sarah, Cambridge, William, White, Olga, Frampton, Adam, Blacker, Sarah, Blackburn, Jessie, Sweeney, Casie, Lykoudis, Pavlos, Field, Daniel, Gouda, Mohammed, Maglione, Manuel, Bellotti, Ruben, Alhaboob, Nassir, Hamid, Hytham K.S., Bari, Hassaan, Ahmed, Hassan, Smith, Andrew, Moriarty, Catherine, White, Louise, Priestley, Mark, Bode, Kerry, Sharp, Judith, Wragg, Rosie, Jackson, Beverley, Craven, Samuel, Spalding, Duncan, Fehervari, Matyas, Pai, Madhava, Alghazawi, Laith, Onifade, Anjola, Srinivasan, Parthi, Ribaud, Julliette, Nair, Ashitha, Mariathasan, Michael, Grayson, Niamh, Davidson, Brian, Pericleous, Stephanos, Krishna Patel, Shaw, Conrad, Morare, Nolitha, Zaban, Mohamad K., Bhogal, Ricky, Doyle, Joseph, Croagh, Daniel, Dominguez, Ismael, Guerrero, Alan, Moguel, Andre, Chan, Carlos, Thakkar, Rohan, Jones, Michael, Buckley, Edward, Akter, Nasreen, Treherne, Kyle, Gomez, Dhanny, Gordon, Gregory, Silva, Michael, Hughes, Daniel, Urbonas, Tomas, Lapolla, Pierfrancesco, Mingoli, Andrea, Brachini, Gioia, Caronna, Roberto, Chirletti, Piero, Porcu, Alberto, Perra, Teresa, Shah, Nehal S., Abd Kahar, Nurul N., Hall, Thomas, Nadeem, Nabeegh, Hamady, Zaed, Karar, Shoura, Arshad, Ali, Al-Sarrieh, Bilal, Yarwood, Adam, Hammoda, Mohammed, Serrablo, Alejandro, Artigas, Maria, Paterna-López, Sandra, Thomasset, Sarah C., Frampton, Adam E., Smith, Andrew M., Davidson, Brian R., Bhogal, Ricky H., Silva, Michael A., and Hamady, Zaed Z.R.
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- 2023
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