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103. Clinical, Endoscopic and Histological Outcomes in Induction of Moderate-to-Severe Ulcerative Colitis: A Systematic Review with Meta-Analysis

Author

Magro, Fernando, primary, Estevinho, Maria Manuela, additional, Dias, Cláudia Camila, additional, Correia, Luís, additional, Lago, Paula, additional, Ministro, Paula, additional, Portela, Francisco, additional, Feakins, Roger, additional, Danese, Silvio, additional, and Peyrin-Biroulet, Laurent, additional

Published
2020
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109. Reply to the letter to the Editor

Author

Urso, Stefano, primary, Sadaba, Rafael, additional, González, Jesús M., additional, Nogales, Eliú, additional, Pettinari, Matteo, additional, Tena, María Á., additional, Paredes, Federico, additional, and Portela, Francisco, additional

Published
2020
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114. Rehospitalization_SupplementaryFigures – Supplemental material for Rehospitalization rates, costs, and risk factors for inflammatory bowel disease: a 16-year nationwide study

Author

Santiago, Mafalda, Magro, Fernando, Correia, Luís, Portela, Francisco, Ministro, Paula, Lago, Paula, Trindade, Eunice, and Dias, Cláudia Camila

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Rehospitalization_SupplementaryFigures for Rehospitalization rates, costs, and risk factors for inflammatory bowel disease: a 16-year nationwide study by Mafalda Santiago, Fernando Magro, Luís Correia, Francisco Portela, Paula Ministro, Paula Lago, Eunice Trindade and Cláudia Camila Dias in Therapeutic Advances in Gastroenterology

Published
2020
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115. Panorama brasileño de la relación entre leptospirosis y inundaciones

Author

Portela, Francisco Carlos, Kobiyama, Masato, and Goerl, Roberto Fabris

Subjects
Inundaciones, Inundações, Brasil [Saúde pública], Leptospirosis, Leptospirose, Salud Pública
Abstract

A leptospirose é uma das doenças de veiculação hídrica que mais preocupam o setor de saúde no Brasil. Portanto, o objetivo deste artigo foi, por meio de levantamento de trabalhos existentes, identificar, analisar e descrever os fatores socioeconômicos, ambientais e climáticos que podem estar diretamente relacionados ao aumento dos casos de leptospirose. Além disso, o presente trabalho fez uma análise temporal e espacial, demonstrando a relação entre publicações e casos/óbitos no Brasil. Por meio de pesquisa nas bases de dados de periódicos CAPES e LILACS, o presente trabalho selecionou 43 artigos que trataram de leptospirose e inundações no Brasil. A maior parte desses trabalhos relacionou a ocorrência de eventos hidrológicos extremos ao aumento do número de casos de leptospirose. Os demais trabalhos relacionam outros fatores como acúmulo de resíduos, falta de drenagem urbana, atividades laborais, entre outros. La leptospirosis es una de las enfermedades de transmisión hídrica que más preocupan al sector de salud en Brasil. Por lo tanto, el objetivo de este artículo fue, por medio de levantamiento de trabajos existentes, identificar, analizar y describir los factores socio-económicos, ambientales y climáticos que pueden estar directamente relacionados con el aumento de los casos de leptospirosis. Además, el presente estudio realizó un análisis temporal y espacial para demostrar la relación entre publicaciones y casos-muertes en Brasil. Por medio de investigación en las bases de datos de revistas CAPES y LILACS, el presente trabajo seleccionó 43 artículos que trataron de leptospirosis e inundaciones en Brasil. La mayor parte de estos trabajos relacionaron la ocurrencia de eventos hidrológicos extremos al aumento del número de casos de leptospirosis. Los demás trabajos relacionan otros factores como la acumulación de residuos, falta de drenaje urbano, actividades laborales, entre otros.

Published
2020

116. sj-pdf-1-tag-10.1177_1756284820965790 – Supplemental material for Rapid test detection of anti-infliximab antibodies: performance comparison with three different immunoassays

Author

Rocha, Cátia, Lago, Paula, Fernandes, Samuel, Correia, Luís, Portela, Francisco, Vieira, Ana Isabel, Patita, Marta, Arroja, Bruno, Ministro, Paula, Alves, Catarina, Dias, Cláudia Camila, and Magro, Fernando

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-tag-10.1177_1756284820965790 for Rapid test detection of anti-infliximab antibodies: performance comparison with three different immunoassays by Cátia Rocha, Paula Lago, Samuel Fernandes, Luís Correia, Francisco Portela, Ana Isabel Vieira, Marta Patita, Bruno Arroja, Paula Ministro, Catarina Alves, Cláudia Camila Dias and Fernando Magro in Therapeutic Advances in Gastroenterology

Published
2020
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117. sj-pdf-2-tag-10.1177_1756284820965790 – Supplemental material for Rapid test detection of anti-infliximab antibodies: performance comparison with three different immunoassays

Author

Rocha, Cátia, Lago, Paula, Fernandes, Samuel, Correia, Luís, Portela, Francisco, Vieira, Ana Isabel, Patita, Marta, Arroja, Bruno, Ministro, Paula, Alves, Catarina, Dias, Cláudia Camila, and Magro, Fernando

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-2-tag-10.1177_1756284820965790 for Rapid test detection of anti-infliximab antibodies: performance comparison with three different immunoassays by Cátia Rocha, Paula Lago, Samuel Fernandes, Luís Correia, Francisco Portela, Ana Isabel Vieira, Marta Patita, Bruno Arroja, Paula Ministro, Catarina Alves, Cláudia Camila Dias and Fernando Magro in Therapeutic Advances in Gastroenterology

Published
2020
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119. Endocarditis infecciosa sobre prótesis valvular aórtica

Author

Moreno Martínez, Francisco Luis, Gómez Guindal, José A., Portela, Francisco, González Gallego, Rocío, Moreno Martínez, Francisco Luis, Gómez Guindal, José A., Portela, Francisco, and González Gallego, Rocío

Published
2020

120. Off-Pump Total Arterial Revascularization: Our Experience

Author

Tarrío, Rubén Fernández, Cuenca, José Joaquin, Gomes, Valdemar, Campos, Vicente, Herrera, José Maria, Rodríguez, Fernando, Valle, José Vicente, Portela, Francisco, García-Carro, Javier, Adrio, Belén, Vázquez, Francisco, and Juffé, Alberto

Published
2004

123. Supplemental_Material – Supplemental material for Soluble human Suppression of Tumorigenicity 2 is associated with endoscopic activity in patients with moderate-to-severe ulcerative colitis treated with golimumab

Author

Magro, Fernando, Lopes, Susana, Silva, Marco, Coelho, Rosa, Portela, Francisco, Branquinho, Diogo, Correia, Luís, Fernandes, Samuel, Cravo, Marília, Caldeira, Paulo, Sousa, Helena Tavares De, Patita, Marta, Lago, Paula, Ramos, Jaime, Afonso, Joana, Redondo, Isabel, Machado, Patrícia, Philip, George, Lopes, Joanne, and Carneiro, Fátima

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplemental_Material for Soluble human Suppression of Tumorigenicity 2 is associated with endoscopic activity in patients with moderate-to-severe ulcerative colitis treated with golimumab by Fernando Magro, Susana Lopes, Marco Silva, Rosa Coelho, Francisco Portela, Diogo Branquinho, Luís Correia, Samuel Fernandes, Marília Cravo, Paulo Caldeira, Helena Tavares de Sousa, Marta Patita, Paula Lago, Jaime Ramos, Joana Afonso, Isabel Redondo, Patrícia Machado, George Philip, Joanne Lopes and Fátima Carneiro in Therapeutic Advances in Gastroenterology

Published
2019
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124. Supplementary_Table_1 – Supplemental material for What forecasting the prevalence of inflammatory bowel disease may tell us about its evolution on a national scale

Author

Santiago, Mafalda, Magro, Fernando, Correia, Luís, Portela, Francisco, Ministro, Paula, Lago, Paula, and Dias, Cláudia Camila

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplementary_Table_1 for What forecasting the prevalence of inflammatory bowel disease may tell us about its evolution on a national scale by Mafalda Santiago, Fernando Magro, Luís Correia, Francisco Portela, Paula Ministro, Paula Lago and Cláudia Camila Dias in Therapeutic Advances in Gastroenterology

Published
2019
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126. Rapid test detection of anti-infliximab antibodies: performance comparison with three different immunoassays

Author

Rocha, Cátia, primary, Lago, Paula, additional, Fernandes, Samuel, additional, Correia, Luís, additional, Portela, Francisco, additional, Vieira, Ana Isabel, additional, Patita, Marta, additional, Arroja, Bruno, additional, Ministro, Paula, additional, Alves, Catarina, additional, Dias, Cláudia Camila, additional, and Magro, Fernando, additional

Published
2020
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129. Comparing the Continuous Geboes Score With the Robarts Histopathology Index: Definitions of Histological Remission and Response and their Relation to Faecal Calprotectin Levels

Author

Magro, Fernando, primary, Lopes, Joanne, primary, Borralho, Paula, primary, Lopes, Susana, primary, Coelho, Rosa, primary, Cotter, José, primary, Dias de Castro, Francisca, primary, Tavares de Sousa, Helena, primary, Salgado, Marta, primary, Andrade, Patrícia, primary, Vieira, Ana Isabel, primary, Figueiredo, Pedro, primary, Caldeira, Paulo, primary, Sousa, A, primary, Duarte, Maria A, primary, Ávila, Filipa, primary, Silva, João, primary, Moleiro, Joana, primary, Mendes, Sofia, primary, Giestas, Sílvia, primary, Ministro, Paula, primary, Sousa, Paula, primary, Gonçalves, Raquel, primary, Gonçalves, Bruno, primary, Oliveira, Ana, primary, Chagas, Cristina, primary, Cravo, Marilia, primary, Dias, Cláudia Camila, primary, Afonso, Joana, primary, Portela, Francisco, primary, Santiago, Mafalda, primary, Geboes, Karel, primary, and Carneiro, Fátima, primary

Published
2019
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130. Sexual Quality of Life in Inflammatory Bowel Disease: A Multicenter, National-Level Study

Author

Roseira, Joana, primary, Magro, Fernando, primary, Fernandes, Samuel, primary, Simões, Carolina, primary, Portela, Francisco, primary, Vieira, Ana Isabel, primary, Patita, Marta, primary, Leal, Carina, primary, Lago, Paula, primary, Caldeira, Paulo, primary, Gago, Tânia, primary, Currais, Pedro, primary, Dias, Cláudia Camila, primary, Santiago, Mafalda, primary, Dias, Sandra, primary, and Tavares de Sousa, Helena, primary

Published
2019
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135. Sa1867 – Sexual Quality of Life in Inflammatory Bowel Disease – a Multicentre, National-Level Study

Author

Roseira, Joana, primary, Magro, Fernando, additional, Fernandes, Samuel R., additional, Simões, Carolina, additional, Portela, Francisco, additional, Vieira, Ana, additional, Patita, Marta, additional, Leal, Carina, additional, Lago, Paula M., additional, Caldeira, Paulo, additional, Gago, Tania, additional, Currais, Pedro, additional, Dias, Camila, additional, and Sousa, Helena T., additional

Published
2019
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137. The influence of self-criticism on depression symptoms among ambulatory patients with inflammatory bowel disease

Author

Trindade, Inês A., Irons, Chris, Ferreira, Cláudia, Portela, Francisco, Pinto-Gouveia, José, Trindade, Inês A., Irons, Chris, Ferreira, Cláudia, Portela, Francisco, and Pinto-Gouveia, José

Abstract

Considering that self-criticism is an important process in the development and maintenance of depression, and taking into account the stigma associated with inflammatory bowel disease (IBD), the present study aimed to analyse whether self-criticism exacerbates the relationships of depression symptoms with IBD symptomatology and chronic illness-related shame. The sample included 53 ambulatory IBD patients (66% females) with ages from 18 to 65. Moderation analyses were conducted using structural equation modelling. Self-criticism exacerbated the associations of depression with IBD symptoms (b = 0.01; standard error [SE] = 0.00; Z = 3.73; P < .001) and illness shame (b = 0.02; SE = 0.01; Z = 2.40; P = .016). For the same level of IBD symptomatology or chronic illness-related shame, those individuals who present more feelings of inadequacy towards the self, experience more symptoms of depression. This exacerbation effect is stronger when IBD symptomatology and chronic illness-related shame are more intense. A high self-critical IBD patient may view the illness and/or symptomatology as a flaw or error that should be self-corrected. Physicians and other health professionals should be attentive to these pathological mechanisms and should attempt to alleviate them. It may be beneficial to refer high self-critical patients to psychological care., This research has been supported by the first author (Ines A Trindade), Ph.D. Grant (SFRH/BD/101906/2014) sponsored by Fundacao para a Ciencia e Tecnologia (Portuguese Foundation for Science and Technology).

Published
2019
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138. 2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients

Author

Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas, Sartelli, Massimo, McFarland, Lynne V., Khanna, Sahil, Furuya Kanamori, Luis, Abuzeid, Nadir, Abu-Zizan, Fikri M., Ansaloni, Luca, Agustin, Goran, Bala, Miklosh, Ben-Ishay, Offir, Biffl, Walter L., Brecher, Stephen M., Camacho Ortiz, Adrián, Caínzos Fernández, Miguel Ángel, Chan, Shirley, Cherry-Bukowiec, Jill R., Clanton, Jesse, Coccolini, Federico, Cocuz, María E., Coimbra, Raúl, Cortese, Francesco, Cui, Yunfeng, Czepiel, Jacek, Demetrashvili, Zaza, Di Carlo, Isidoro, Di Saverio, Salomone, Dumitru, Irina M., Eckmann, Christian, Eiland, Edward H., Forrester, Joseph D., Fraga, Gustavo P., Frossard, Jean L., Fry, Donald E., Galeiras, Rita, Ghnnam, Wagih, Gomes, Carlos A., Griffiths, Ewen A., Guirao, Xavier, Ahmed, Mohamed H., Herzog, Torsten, Kim, Jae II, Iqbal, Tariq, Isik, Arda, Itani, Kamal M.F., Labricciosa, Francesco M., Lee, Yeong Y., Juang, Paul, Karamarkovic, Aleksandar, Kim, Peter K., Kluger, Yoram, Leppaniemi, Ari, Lohsiriwat, Varut, Machain, Gustavo M., Marwah, Sanjay, Mazuski, John E., Metan, Gokhan, Moore, Ernest E., Moore, Frederick A., Ordoñez, Carlos A., Pagani, Leonardo, Petrosillo, Nicola, Portela, Francisco, Rasa, Kemal, Rems, Miran, Sakakushev, Boris E., Segovia-Lohse, Helmut, Sganga, Gabriele, Shelat, Vishal G., Spigaglia, Patrizia, Tattevin, Pierre, Tranà, Cristian, Urbánek, Libor, Ulrych, Jan, Viale, Pierluigi, Catena, Fausto, Di Bella, Stefano, Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas, Sartelli, Massimo, McFarland, Lynne V., Khanna, Sahil, Furuya Kanamori, Luis, Abuzeid, Nadir, Abu-Zizan, Fikri M., Ansaloni, Luca, Agustin, Goran, Bala, Miklosh, Ben-Ishay, Offir, Biffl, Walter L., Brecher, Stephen M., Camacho Ortiz, Adrián, Caínzos Fernández, Miguel Ángel, Chan, Shirley, Cherry-Bukowiec, Jill R., Clanton, Jesse, Coccolini, Federico, Cocuz, María E., Coimbra, Raúl, Cortese, Francesco, Cui, Yunfeng, Czepiel, Jacek, Demetrashvili, Zaza, Di Carlo, Isidoro, Di Saverio, Salomone, Dumitru, Irina M., Eckmann, Christian, Eiland, Edward H., Forrester, Joseph D., Fraga, Gustavo P., Frossard, Jean L., Fry, Donald E., Galeiras, Rita, Ghnnam, Wagih, Gomes, Carlos A., Griffiths, Ewen A., Guirao, Xavier, Ahmed, Mohamed H., Herzog, Torsten, Kim, Jae II, Iqbal, Tariq, Isik, Arda, Itani, Kamal M.F., Labricciosa, Francesco M., Lee, Yeong Y., Juang, Paul, Karamarkovic, Aleksandar, Kim, Peter K., Kluger, Yoram, Leppaniemi, Ari, Lohsiriwat, Varut, Machain, Gustavo M., Marwah, Sanjay, Mazuski, John E., Metan, Gokhan, Moore, Ernest E., Moore, Frederick A., Ordoñez, Carlos A., Pagani, Leonardo, Petrosillo, Nicola, Portela, Francisco, Rasa, Kemal, Rems, Miran, Sakakushev, Boris E., Segovia-Lohse, Helmut, Sganga, Gabriele, Shelat, Vishal G., Spigaglia, Patrizia, Tattevin, Pierre, Tranà, Cristian, Urbánek, Libor, Ulrych, Jan, Viale, Pierluigi, Catena, Fausto, and Di Bella, Stefano

Abstract

In the last three decades, Clostridium difficile infection (CDI) has increased in incidence and severity in many countries worldwide. The increase in CDI incidence has been particularly apparent among surgical patients. Therefore, prevention of CDI and optimization of management in the surgical patient are paramount. An international multidisciplinary panel of experts from the World Society of Emergency Surgery (WSES) updated its guidelines for management of CDI in surgical patients according to the most recent available literature. The update includes recent changes introduced in the management of this infection

Published
2019

139. Transparência e acesso ao controle social

Author

Lima, Emerson Carvalho de, Portela, Francisco Carlos, Lima, Emerson Carvalho de, and Portela, Francisco Carlos

Abstract

This paper aims to understand the process of transparency of State public administration and its insertion in the Brazilian Transparency Portal so that the society can have clear and full access. Such theme is justified due to society’s demand for a more democratic and ethical administration in which all information inherent to the State can be shared with everyone who is part of this process. Given this, we seek to understand how public transparency of administration occurs, what is transparency, how it arose, what is the main purpose of the transparency portal and finally, how the management of the information works in the government platform. To answer this question, the bibliographic methodology was used in the research, and as a result, it was possible to verify the importance of transparency and social control for a quality public administration., Este artigo visa compreender o processo de transparência da gestão pública do Estado e a sua inserção no Portal da Transparência, para que a sociedade possa ter acesso de forma clara e plena. Tal temática se justifica em função da cobrança da sociedade por uma gestão mais democrática e ética, em que todas as informações inerentes à gestão do Estado possam ser compartilhadas com aqueles que fazem parte desse processo. Diante disso, busca-se compreender como ocorre a transparência pública da gestão; o que é essa transparência; como surgiu e qual é a finalidade maior do Portal da Transparência; e, por último, como funciona o gerenciamento das informações da gestão na plataforma governamental. Para responder a esse questionamento buscou-se utilizar na pesquisa a metodologia bibliográfica e, como resultado, verificou-se a importância da transparência e do controle social para uma gestão pública de qualidade.

Published
2019

140. 2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients 11 Medical and Health Sciences 1103 Clinical Sciences

Author

Sartelli, Massimo, Di Bella, Stefano, Mcfarland, Lynne V., Khanna, Sahil, Furuya-Kanamori, Lui, Abuzeid, Nadir, Abu-Zidan, Fikri M., Ansaloni, Luca, Augustin, Goran, Bala, Miklosh, Ben-Ishay, Offir, Biffl, Walter L., Brecher, Stephen M., Camacho-Ortiz, Adrián, Caínzos, Miguel A., Chan, Shirley, Cherry-Bukowiec, Jill R., Clanton, Jesse, Coccolini, Federico, Cocuz, Maria E., Coimbra, Raul, Cortese, Francesco, Cui, Yunfeng, Czepiel, Jacek, Demetrashvili, Zaza, Di Carlo, Isidoro, Di Saverio, Salomone, Dumitru, Irina M., Eckmann, Christian, Eiland, Edward H., Forrester, Joseph D., Fraga, Gustavo P., Frossard, Jean L., Fry, Donald E., Galeiras, Rita, Ghnnam, Wagih, Gomes, Carlos A., Griffiths, Ewen A., Guirao, Xavier, Ahmed, Mohamed H., Herzog, Torsten, Kim, Jae Il, Iqbal, Tariq, Isik, Arda, Itani, Kamal M. F., Labricciosa, Francesco M., Lee, Yeong Y., Juang, Paul, Karamarkovic, Aleksandar, Kim, Peter K., Kluger, Yoram, Leppaniemi, Ari, Lohsiriwat, Varut, Machain, Gustavo M., Marwah, Sanjay, Mazuski, John E., Metan, Gokhan, Moore, Ernest E., Moore, Frederick A., Ordoñez, Carlos A., Pagani, Leonardo, Petrosillo, Nicola, Portela, Francisco, Rasa, Kemal, Rems, Miran, Sakakushev, Boris E., Segovia-Lohse, Helmut, Sganga, Gabriele, Shelat, Vishal G., Spigaglia, Patrizia, Tattevin, Pierre, Tranà, Cristian, Urbánek, Libor, Ulrych, Jan, Viale, Pierluigi, Baiocchi, Gian L., Catena, Fausto, Sganga, Gabriele (ORCID:0000-0001-5079-0395), Sartelli, Massimo, Di Bella, Stefano, Mcfarland, Lynne V., Khanna, Sahil, Furuya-Kanamori, Lui, Abuzeid, Nadir, Abu-Zidan, Fikri M., Ansaloni, Luca, Augustin, Goran, Bala, Miklosh, Ben-Ishay, Offir, Biffl, Walter L., Brecher, Stephen M., Camacho-Ortiz, Adrián, Caínzos, Miguel A., Chan, Shirley, Cherry-Bukowiec, Jill R., Clanton, Jesse, Coccolini, Federico, Cocuz, Maria E., Coimbra, Raul, Cortese, Francesco, Cui, Yunfeng, Czepiel, Jacek, Demetrashvili, Zaza, Di Carlo, Isidoro, Di Saverio, Salomone, Dumitru, Irina M., Eckmann, Christian, Eiland, Edward H., Forrester, Joseph D., Fraga, Gustavo P., Frossard, Jean L., Fry, Donald E., Galeiras, Rita, Ghnnam, Wagih, Gomes, Carlos A., Griffiths, Ewen A., Guirao, Xavier, Ahmed, Mohamed H., Herzog, Torsten, Kim, Jae Il, Iqbal, Tariq, Isik, Arda, Itani, Kamal M. F., Labricciosa, Francesco M., Lee, Yeong Y., Juang, Paul, Karamarkovic, Aleksandar, Kim, Peter K., Kluger, Yoram, Leppaniemi, Ari, Lohsiriwat, Varut, Machain, Gustavo M., Marwah, Sanjay, Mazuski, John E., Metan, Gokhan, Moore, Ernest E., Moore, Frederick A., Ordoñez, Carlos A., Pagani, Leonardo, Petrosillo, Nicola, Portela, Francisco, Rasa, Kemal, Rems, Miran, Sakakushev, Boris E., Segovia-Lohse, Helmut, Sganga, Gabriele, Shelat, Vishal G., Spigaglia, Patrizia, Tattevin, Pierre, Tranà, Cristian, Urbánek, Libor, Ulrych, Jan, Viale, Pierluigi, Baiocchi, Gian L., Catena, Fausto, and Sganga, Gabriele (ORCID:0000-0001-5079-0395)

Abstract

In the last three decades, Clostridium difficile infection (CDI) has increased in incidence and severity in many countries worldwide. The increase in CDI incidence has been particularly apparent among surgical patients. Therefore, prevention of CDI and optimization of management in the surgical patient are paramount. An international multidisciplinary panel of experts from the World Society of Emergency Surgery (WSES) updated its guidelines for management of CDI in surgical patients according to the most recent available literature. The update includes recent changes introduced in the management of this infection.

Published
2019

141. Composite outcomes in observational studies of ulcerative colitis: A systematic review and meta‐analysis

Author

Magro, Fernando, Alves, Catarina, Santiago, Mafalda, Ministro, Paula, Lago, Paula, Correia, Luís, Gonçalves, Raquel, Carvalho, Diana, Portela, Francisco, Dias, Cláudia Camila, Dignass, Axel, Danese, Silvio, Peyrin‐Biroulet, Laurent, Estevinho, Maria Manuela, and Moreira, Paula

Abstract

Ulcerative colitis (UC) has been the focus of numerous observational studies over the years and a common strategy employed in their design is the use of composite and aggregate outcomes. This systematic review and meta‐analysis aims to identify composite and aggregate outcomes of observational studies in UC and to evaluate how the number and type of variables included and the length of follow‐up affect the frequency of patients that achieve these outcomes. A systematic literature search was carried out using MEDLINE [via PubMed], Scopus, and Web of Science online databases. Observational studies that included UC patients and reported composite or aggregate outcomes were identified. A set of variables considered to be representative of progressive or disabling UC was defined, the proportion of patients attaining the outcomes was determined and a random‐effects meta‐analysis was performed by dividing the identified studies into subgroups according to different criteria of interest. A total of 10,264 records were identified in the systematic search, of which 33 were retained for qualitative analysis and 20 were included in the meta‐analysis. The mean frequency for composite outcomes was 0.363 [95% confidence interval (CI) 0.323‐0.403]. The frequency of composite outcome for the subgroup of studies that included the variable “Biologics” was significantly higher than for those in which this variable was not reported [0.410; 95% CI 0.364‐0.457 versus 0.298; 95% CI 0.232‐0.364; p= 0.006]. Composite outcomes were also more frequent as the follow‐up duration increased. The frequency of composite outcomes in observational studies of UC is dependent on the specific identity of the variables being reported. Moreover, longer follow‐up periods are associated with higher frequencies of composite outcomes. The evidence provided here is useful for the design of future observational studies of UC that aim to maximize the frequency of patients that achieve composite outcomes. Summarize the established knowledge on this subjectObservational studies have become a valuable source of information but also present a remarkable heterogeneity.The inconsistency on the reported outcomes between individual studies and the potential for reporting biases has led to calls for the development of core outcome sets (COS).What are the significant and/or new findings of this study?This is the first systematic review and meta‐analysis of outcomes in observational studies of Ulcerative colitis (UC).The frequency of composite outcomes in observational studies of UC is dependent on the specific identity of the variables being reported and on the follow‐up duration.Reporting of the variable “Biologics” significantly increased the frequency of composite outcomes.These findings may be useful for the design of future observational studies of UC. Summarize the established knowledge on this subject Observational studies have become a valuable source of information but also present a remarkable heterogeneity. The inconsistency on the reported outcomes between individual studies and the potential for reporting biases has led to calls for the development of core outcome sets (COS). What are the significant and/or new findings of this study? This is the first systematic review and meta‐analysis of outcomes in observational studies of Ulcerative colitis (UC). The frequency of composite outcomes in observational studies of UC is dependent on the specific identity of the variables being reported and on the follow‐up duration. Reporting of the variable “Biologics” significantly increased the frequency of composite outcomes. These findings may be useful for the design of future observational studies of UC.

Published
2022
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142. Clinical, Endoscopic and Histological Outcomes in Induction of Moderate-to-Severe Ulcerative Colitis: A Systematic Review with Meta-Analysis.

Author

Magro, Fernando, Estevinho, Maria Manuela, Dias, Cláudia Camila, Correia, Luís, Lago, Paula, Ministro, Paula, Portela, Francisco, Feakins, Roger, Danese, Silvio, and Peyrin-Biroulet, Laurent

Abstract

Background and Aims Interest in histology for ulcerative colitis [UC] has increased recently. This systematic review and meta-analysis aims to assess, for the first time, whether histological outcomes are more informative than endoscopic and clinical outcomes in distinguishing the impact of intervention over placebo in induction trials. Methods MEDLINE, ScienceDirect and Cochrane Central Register of Controlled Trials were searched to identify randomized placebo-controlled trials [RCTs] enrolling moderate-to-severe UC patients. Studies were assessed using the Quality Assessment Tool for Studies with Diverse Designs. We analysed the pooled proportion of patients achieving clinical, endoscopic and histological remission and response after a pharmacological intervention and compared the results with those of placebo-treated patients by using a random-effects model. Results From 889 identified records, 13 RCTs were included. The odds ratio [OR] for remission was higher in patients receiving intervention than in those under placebo for clinical (OR 2.13, 95% confidence interval [CI] 1.33–3.43), endoscopic [OR 1.46, 95% CI 0.19–11.18] and histological remission [OR 1.85, 95% CI 1.20–2.84]. Significant differences were observed for all response outcomes [clinical: OR 2.27, 95% CI 1.84–2.85; endoscopic: OR 2.16, 95% CI 1.51–3.10; histological: OR 3.63, 95% CI, 1.41–9.36]. No significant heterogeneity existed; no subgroup effects were found for duration of the induction or histological scale [ p  > 0.05]. Clinical and histological remission and endoscopic response were concordant in discriminating interventions from placebo. Conclusion Histological outcomes are informative in trials of moderate-to-severe UC. Further studies analysing histology at the end of induction are needed to confirm its relevance in distinguishing the efficacy of an intervention over placebo in comparison to clinical and endoscopic outcomes and to explore its prognostic value. [ABSTRACT FROM AUTHOR]

Published
2021
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143. Estudo sobre a incidência de leptospirose relacionada a inundações e indicadores de desenvolvimento humano em Santa Catarina

Author

Portela, Francisco Carlos, Universidade Federal de Santa Catarina, Kobiyama, Masato, and Goerl, Roberto Fabris

Subjects
Desastres, Inundações, Saúde pública, Leptospirose
Abstract

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-graduação em Desastes Naturais, Florianópolis, 2018. A leptospirose é uma das doenças de veiculação hídrica que mais preocupam o setor de saúde no Brasil e está relacionada às más condições de saneamento básico e moradias, causando sérios impactos socioeconômicos nas localidades atingidas. O risco de surtos de leptospirose revela, assim, uma deficiência nas políticas de prevenção e controle. Causada pela bactéria leptospira, presente na urina de ratos, tem sua transmissão favorecida em épocas de fortes precipitações e consequentes inundações, ao se misturar às águas provocando contaminação e, no caso de contato humano, contágio. Santa Catarina, por sua localização geográfica, é um dos estados brasileiros que apresenta melhor distribuição de precipitação pluviométrica durante o ano. Diante de tal situação, torna-se relevante analisar a incidência de leptospirose em Santa Catarina relacionada à ocorrência de inundações e aos indicadores de desenvolvimento humano. Para alcançar o objetivo proposto nesta dissertação, a metodologia de trabalho foi baseada na revisão da literatura sobre leptospirose no Brasil e no levantamento e mapeamento de dados sobre casos de leptospirose e óbitos pela doença registrados em Santa Catarina, inundações e indicadores de desenvolvimento humano nos municípios catarinenses. Na revisão bibliográfica, os estudos demonstraram, nacionalmente, uma relação direta entre a incidência de surtos de leptospirose e a ocorrência de inundações. Já na análise da relação temporal entre a incidência dos casos da doença nos municípios de Santa Catarina e as duas variantes propostas (inundações e Índice de Desenvolvimento Humano - IDH), o resultado foi diferenciado; o IDH demonstrou não ser um indicador adequado para explicar a incidência de leptospirose relacionada à ocorrência de inundações. Estudos aplicando outras variáveis mostram-se necessários para melhor explicar os fatores condicionantes e determinantes para a incidência de leptospirose em Santa Catarina. Abstract: Leptospirosis is one of the waterborne diseases that most concern the health sector in Brazil and is related to bad conditions of basic sanitation and housing, causing serious socioeconomic impacts in the affected areas. The risk of outbreaks of leptospirosis thus reveals a deficiency in prevention and control policies. Caused by the bacterium leptospira, present in the urine of rats, its transmission is favored in times of heavy rainfall and consequent flooding, when mixing with the water causing contamination and, in the case of human contact, contagion. Santa Catarina, due to its geographic location, is one of the Brazilian states that presents a better distribution of rainfall during the year. In view of this situation, it is relevant to analyze the incidence of leptospirosis in Santa Catarina related to the occurrence of floods and indicators of human development. In order to reach the objective proposed in this dissertation, the methodology was based on the literature review on leptospirosis in Brazil and on the collection and mapping of data on cases of leptospirosis and deaths from the disease in Santa Catarina, floods and indicators of human development in municipalities Santa Catarina. In the bibliographic review, the studies demonstrated, nationally, a direct relation between the incidence of leptospirosis outbreaks and the occurrence of floods. In the analysis of the temporal relation between the incidence of the disease cases in the municipalities of Santa Catarina and the two proposed variants (floods and Human Development Index - HDI), the result was differentiated; the HDI has not been shown to be an adequate indicator to explain the incidence of leptospirosis related to the occurrence of floods. Studies applying other variables are necessary to better explain the conditioning factors and determinants for the incidence of leptospirosis in Santa Catarina.

Published
2018

144. Corrupção no Brasil após a operação Lava Jato: a percepção dos brasileiros que estão cursando Pós-Graduação na Universidade Fernando Pessoa

Author

Portela, Francisco Carlos and Cardoso, António

Subjects
Percepção da Corrupção, Corrupção no Brasil, Operação Lava Jato, Corruption in Brazil, Perception of Corruption, Operation Lava Jet, Ciências Sociais::Economia e Gestão [Domínio/Área Científica]
Abstract

Submitted by halves@ufp.pt (halves@ufp.pt) on 2017-07-26T14:08:34Z No. of bitstreams: 1 DM_Francisco Portela.pdf: 2254338 bytes, checksum: 9b5826bd33835e154f04fd32649fd2d0 (MD5) Approved for entry into archive by halves@ufp.pt (halves@ufp.pt) on 2017-07-26T14:12:15Z (GMT) No. of bitstreams: 1 DM_Francisco Portela.pdf: 2254338 bytes, checksum: 9b5826bd33835e154f04fd32649fd2d0 (MD5) Made available in DSpace on 2017-07-26T14:12:15Z (GMT). No. of bitstreams: 1 DM_Francisco Portela.pdf: 2254338 bytes, checksum: 9b5826bd33835e154f04fd32649fd2d0 (MD5) Previous issue date: 2017-07-21

Published
2017

148. Soluble human Suppression of Tumorigenicity 2 is associated with endoscopic activity in patients with moderate-to-severe ulcerative colitis treated with golimumab

Author

Magro, Fernando, primary, Lopes, Susana, additional, Silva, Marco, additional, Coelho, Rosa, additional, Portela, Francisco, additional, Branquinho, Diogo, additional, Correia, Luís, additional, Fernandes, Samuel, additional, Cravo, Marília, additional, Caldeira, Paulo, additional, Tavares de Sousa, Helena, additional, Patita, Marta, additional, Lago, Paula, additional, Ramos, Jaime, additional, Afonso, Joana, additional, Redondo, Isabel, additional, Machado, Patrícia, additional, Philip, George, additional, Lopes, Joanne, additional, and Carneiro, Fátima, additional

Published
2019
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149. Health-Related Quality of Life in Patients with Moderate to Severe Ulcerative Colitis: Surgical Intervention versus Immunomodulatory Therapy.

Author

Portela, Francisco, Ministro, Paula, de Deus, João, Cravo, Marilia, Cotter, José, Duque, Gabriela, Ferreira, Frederico, Rosa, Bruno, Ferreira, Pedro Lopez, Dias, Claudia Camila, and Magro, Fernando

Subjects
*ULCERATIVE colitis, *QUALITY of life, *INFLAMMATORY bowel diseases, *DRUG utilization
Abstract

Purpose: Ulcerative colitis (UC) can be managed with immunomodulation or surgery. We aimed to understand whether these strategies had a different impact on patients' health-related quality of life (HRQoL). Methods: This was a retrospective, cross-sectional study: patients who had a moderate to severe UC episode that prompted the utilization of immunomodulatory drugs or surgery were invited to complete a generic (short form [36] health survey [SF-36]) and a disease-specific (inflammatory bowel disease questionnaire [IBDQ]) survey. Results: We included 157 patients, 65 (41.4%) surgically treated. The therapeutic procedure had a minimal impact on HRQoL: only the social dimension of the IBDQ and the physical function component of the SF-36 were significantly different between the study arms – lower for the surgically treated patients. The type of surgery had no impact, but the occurrence of pouchitis, namely, in a chronic form, was associated with a lower HRQoL. Regression analysis confirmed surgery as an independent predictor of lower scores in the social dimension of the IBDQ (–4.646, 95% CI –6.953 to –2.339) and in the physical functioning (–9.622, 95% CI –17.061 to –2.183) and physical role functioning (–3.669, 95% CI –7.339 to 0.001) dimensions of the SF36. Conclusions: Although usually feared by patients, surgery has a limited impact on UC patients HRQoL when compared to medical management with immunomodulatory drugs. [ABSTRACT FROM AUTHOR]

Published
2020
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150. PANORAMA BRASILEIRO DA RELAÇÃO ENTRE LEPTOSPIROSE E INUNDAÇÕES.

Author

Carlos Portela, Francisco, Kobiyama, Masato, and Fabris Goerl, Roberto

Subjects
*LEPTOSPIROSIS, *DATABASE searching, *WATERBORNE infection, *DRAINAGE, *FLOODS, *PUBLIC health
Abstract

Leptospirosis is one of the waterborne diseases that strongly concern the health in Brazil. Therefore, the objective of the present study was to identify, analyze, and describe the socioeconomic, environmental, and climatic factors that can be directly related to the increase of the leptospirosis cases. In addition, the present study carried out a temporal and spatial analysis to demonstrate the relationship between publications and cases-deaths in Brazil. By searching the databases of the CAPES and LILACS, we selected 43 papers that dealt with leptospirosis and flood in Brazil. Most of the evaluated papers related the occurrence of extreme hydrological events to the increase in the number of cases of leptospirosis. The others focused other factors such as waste accumulation, lack of urban drainage, working services, and so on. [ABSTRACT FROM AUTHOR]

Published
2020
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