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101. Bile Acid Physiology

Author

Di Ciaula, Agostino, Garruti, Gabriella, Lunardi Baccetto, Raquel, Molina-Molina, Emilio, Bonfrate, Leonilde, Wang, David Q.-H., and Portincasa, Piero

Published
2017
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110. Diagnostic delay in adult coeliac disease: An Italian multicentre study

Author

Lenti, Marco Vincenzo, Aronico, Nicola, Bianchi, Paola Ilaria, D'Agate, Carmela Cinzia, Neri, Matteo, Volta, Umberto, Mumolo, Maria Gloria, Astegiano, Marco, Calabrò, Antonino Salvatore, Zingone, Fabiana, Latella, Giovanni, Di Sario, Antonio, Carroccio, Antonio, Ciacci, Carolina, Luzza, Francesco, Bagnato, Carmela, Fantini, Massimo Claudio, Elli, Luca, Cammarota, Giovanni, Gasbarrini, Antonio, Portincasa, Piero, Latorre, Mario Andrea, Petrucci, Clarissa, Quatraccioni, Claudia, Iannelli, Chiara, Vecchione, Nicoletta, Rossi, Carlo Maria, Broglio, Giacomo, Ianiro, Gianluca, Marsilio, Ilaria, Bibbò, Stefano, Marinoni, Beatrice, Tomaselli, Donatella, Abenavoli, Ludovico, Pilia, Riccardo, Santacroce, Giovanni, Lynch, Erica, Carrieri, Antonella, Mansueto, Pasquale, Gabba, Margherita, Alunno, Giacomo, Rossi, Chiara, Onnis, Francesca, Efthymakis, Konstantino, Cesaro, Nicola, Vernero, Marta, Baiano Svizzero, Federica, Semeraro, Francesco Paolo, Silano, Marco, Vanoli, Alessandro, Klersy, Catherine, Corazza, Gino Roberto, Di Sabatino, Antonio, Cammarota, Giovanni (ORCID:0000-0002-3626-6148), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Ianiro, Gianluca (ORCID:0000-0002-8318-0515), Rossi, Chiara (ORCID:0000-0002-3570-2710), Lenti, Marco Vincenzo, Aronico, Nicola, Bianchi, Paola Ilaria, D'Agate, Carmela Cinzia, Neri, Matteo, Volta, Umberto, Mumolo, Maria Gloria, Astegiano, Marco, Calabrò, Antonino Salvatore, Zingone, Fabiana, Latella, Giovanni, Di Sario, Antonio, Carroccio, Antonio, Ciacci, Carolina, Luzza, Francesco, Bagnato, Carmela, Fantini, Massimo Claudio, Elli, Luca, Cammarota, Giovanni, Gasbarrini, Antonio, Portincasa, Piero, Latorre, Mario Andrea, Petrucci, Clarissa, Quatraccioni, Claudia, Iannelli, Chiara, Vecchione, Nicoletta, Rossi, Carlo Maria, Broglio, Giacomo, Ianiro, Gianluca, Marsilio, Ilaria, Bibbò, Stefano, Marinoni, Beatrice, Tomaselli, Donatella, Abenavoli, Ludovico, Pilia, Riccardo, Santacroce, Giovanni, Lynch, Erica, Carrieri, Antonella, Mansueto, Pasquale, Gabba, Margherita, Alunno, Giacomo, Rossi, Chiara, Onnis, Francesca, Efthymakis, Konstantino, Cesaro, Nicola, Vernero, Marta, Baiano Svizzero, Federica, Semeraro, Francesco Paolo, Silano, Marco, Vanoli, Alessandro, Klersy, Catherine, Corazza, Gino Roberto, Di Sabatino, Antonio, Cammarota, Giovanni (ORCID:0000-0002-3626-6148), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Ianiro, Gianluca (ORCID:0000-0002-8318-0515), and Rossi, Chiara (ORCID:0000-0002-3570-2710)

Abstract

Background: There are few data regarding the diagnostic delay and its predisposing factors in coeliac disease (CD). Aims: To investigate the overall, the patient-dependant, and the physician-dependant diagnostic delays in CD. Methods: CD adult patients were retrospectively enroled at 19 Italian CD outpatient clinics (2011-2021). Overall, patient-dependant, and physician-dependant diagnostic delays were assessed. Extreme diagnostic, i.e., lying above the third quartile of our population, was also analysed. Multivariable regression models for factors affecting the delay were fitted. Results: Overall, 2362 CD patients (median age at diagnosis 38 years, IQR 27-46; M:F ratio=1:3) were included. The median overall diagnostic delay was 8 months (IQR 5-14), while patient- and physician-dependant delays were 3 (IQR 2-6) and 4 (IQR 2-6) months, respectively. Previous misdiagnosis was associated with greater physician-dependant (1.076, p = 0.005) and overall (0.659, p = 0.001) diagnostic delays. Neurological symptoms (odds ratio 2.311, p = 0.005) and a previous misdiagnosis (coefficient 9.807, p = 0.000) were associated with a greater extreme physician-dependant delay. Gastrointestinal symptoms (OR 1.880, p = 0.004), neurological symptoms (OR 2.313, p = 0.042), and previous misdiagnosis (OR 4.265, p = 0.000) were associated with increased extreme overall diagnostic delay. Conclusion: We identified some factors that hamper CD diagnosis. A proper screening strategy for CD should be implemented.

Published
2023

111. Systematic review with meta-analysis: branched-chain amino acid supplementation in liver disease

Author

Afdeling Dietetiek, Cancer, Epi Kanker Team C, MS Hoofd-Hals Chirurgische Oncologie, VS-DIGD, MS MDL 1, Infection & Immunity, van Dijk, Anne M, Bruins Slot, Alexandra S, Portincasa, Piero, Siegerink, Sebastiaan N, Chargi, Najiba, Verstraete, Carina J R, Bruijne, Joep de, Vleggaar, Frank P, van Erpecum, Karel J, Afdeling Dietetiek, Cancer, Epi Kanker Team C, MS Hoofd-Hals Chirurgische Oncologie, VS-DIGD, MS MDL 1, Infection & Immunity, van Dijk, Anne M, Bruins Slot, Alexandra S, Portincasa, Piero, Siegerink, Sebastiaan N, Chargi, Najiba, Verstraete, Carina J R, Bruijne, Joep de, Vleggaar, Frank P, and van Erpecum, Karel J

Published
2023

114. Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Author

Giorgi, Carlotta, primary, Marchi, Saverio, additional, Simoes, Ines C.M., additional, Ren, Ziyu, additional, Morciano, Giampaolo, additional, Perrone, Mariasole, additional, Patalas-Krawczyk, Paulina, additional, Borchard, Sabine, additional, Jędrak, Paulina, additional, Pierzynowska, Karolina, additional, Szymański, Jędrzej, additional, Wang, David Q., additional, Portincasa, Piero, additional, Węgrzyn, Grzegorz, additional, Zischka, Hans, additional, Dobrzyn, Pawel, additional, Bonora, Massimo, additional, Duszynski, Jerzy, additional, Rimessi, Alessandro, additional, Karkucinska-Wieckowska, Agnieszka, additional, Dobrzyn, Agnieszka, additional, Szabadkai, Gyorgy, additional, Zavan, Barbara, additional, Oliveira, Paulo J., additional, Sardao, Vilma A., additional, Pinton, Paolo, additional, and Wieckowski, Mariusz R., additional

Published
2018
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116. Efficacy of a new nutraceutical formulation: L-tryptophan, probiotics, charcoal, chamomile, mint, and licorice (COLONIR®) in the improvement of gastrointestinal symptoms in subjects with irritable bowel syndrome

Author

FIORINI, Giulia, primary, SARACINO, Ilaria M., additional, PAVONI, Matteo, additional, NIPOTE, Bruno, additional, COLUCCI, Raffaele, additional, CAPONE, Pietro, additional, SANNINO, Angela, additional, FORTE, Fabrizio, additional, DE VERGORI, Emiliano, additional, BRANCACCIO, Mario, additional, CESAREO, Maurizio, additional, CASELLA, Giovanni, additional, MORREALE, Gaetano C., additional, BONFRATE, Leonilde, additional, PORTINCASA, Piero, additional, VINCENZI, Massimo, additional, COTTONE, Carmelo, additional, ORMANDO, Vittorio M., additional, SCALISE, Natale, additional, LAWSON, Paulin F., additional, BURATTINI, Osvaldo, additional, MONTALE, Amedeo, additional, LUZZA, Francesco, additional, ROSSI, Mauro, additional, VANNI, Riccardo, additional, BOZZI, Rosamaria, additional, VINCOLI, Giuseppina, additional, STEFANI, Nicoletta, additional, BORGHI, Claudio, additional, and VAIRA, Dino, additional

Published
2023
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117. Novel inflammatory markers in patients with severe COVID-19 and a pulmonary thrombotic event

Author

Bakiera, Jarosław, primary, Strzelec-Pawełczak, Karolina, additional, Czarnek, Katarzyna, additional, Osuchowska-Grochowska, Ida, additional, Bogucki, Jacek, additional, Markiewicz-Gospodarek, Agnieszka, additional, Górska, Aleksandra, additional, Chilimoniuk, Zuzanna, additional, Radej, Sebastian, additional, Szymański, Mateusz, additional, Portincasa, Piero, additional, and Grochowski, Cezary, additional

Published
2023
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119. Post COVID-19 irritable bowel syndrome

Author

Marasco, Giovanni, primary, Cremon, Cesare, additional, Barbaro, Maria Raffaella, additional, Cacciari, Giulia, additional, Falangone, Francesca, additional, Kagramanova, Anna, additional, Bordin, Dmitry, additional, Drug, Vasile, additional, Miftode, Egidia, additional, Fusaroli, Pietro, additional, Mohamed, Salem Youssef, additional, Ricci, Chiara, additional, Bellini, Massimo, additional, Rahman, Mohammed Masudur, additional, Melcarne, Luigi, additional, Santos, Javier, additional, Lobo, Beatriz, additional, Bor, Serhat, additional, Yapali, Suna, additional, Akyol, Deniz, additional, Sapmaz, Ferdane Pirincci, additional, Urun, Yonca Yilmaz, additional, Eskazan, Tugce, additional, Celebi, Altay, additional, Kacmaz, Huseyin, additional, Ebik, Berat, additional, Binicier, Hatice Cilem, additional, Bugdayci, Mehmet Sait, additional, Yağcı, Munkhtsetseg Banzragch, additional, Pullukcu, Husnu, additional, Kaya, Berrin Yalınbas, additional, Tureyen, Ali, additional, Hatemi, İbrahim, additional, Koc, Elif Sitre, additional, Sirin, Goktug, additional, Calıskan, Ali Riza, additional, Bengi, Goksel, additional, Alıs, Esra Ergun, additional, Lukic, Snezana, additional, Trajkovska, Meri, additional, Hod, Keren, additional, Dumitrascu, Dan, additional, Pietrangelo, Antonello, additional, Corradini, Elena, additional, Simren, Magnus, additional, Sjölund, Jessica, additional, Tornkvist, Navkiran, additional, Ghoshal, Uday C, additional, Kolokolnikova, Olga, additional, Colecchia, Antonio, additional, Serra, Jordi, additional, Maconi, Giovanni, additional, De Giorgio, Roberto, additional, Danese, Silvio, additional, Portincasa, Piero, additional, Di Sabatino, Antonio, additional, Maggio, Marcello, additional, Philippou, Elena, additional, Lee, Yeong Yeh, additional, Salvi, Daniele, additional, Venturi, Alessandro, additional, Borghi, Claudio, additional, Zoli, Marco, additional, Gionchetti, Paolo, additional, Viale, Pierluigi, additional, Stanghellini, Vincenzo, additional, and Barbara, Giovanni, additional

Published
2022
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121. Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Author

Eijsbouts, Chris, Zheng, Tenghao, Kennedy, Nicholas A., Bonfiglio, Ferdinando, Anderson, Carl A., Moutsianas, Loukas, Holliday, Joanne, Shi, Jingchunzi, Shringarpure, Suyash, Voda, Alexandru-Ioan, Farrugia, Gianrico, Franke, Andre, H��benthal, Matthias, Abecasis, Gon��alo, Zawistowski, Matthew, Skogholt, Anne Heidi, Ness-Jensen, Eivind, Hveem, Kristian, Esko, T��nu, Teder-Laving, Maris, Zhernakova, Alexandra, Camilleri, Michael, Boeckxstaens, Guy, Whorwell, Peter J., Spiller, Robin, McVean, Gil, D���Amato, Mauro, Jostins, Luke, Parkes, Miles, Agee, Michelle, Aslibekyan, Stella, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Clark, Sarah K., Elson, Sarah L., Fletez-Brant, Kipper, Fontanillas, Pierre, Furlotte, Nicholas A., Gandhi, Pooja M., Heilbron, Karl, Hicks, Barry, Hinds, David A., Huber, Karen E., Jewett, Ethan M., Jiang, Yunxuan, Kleinman, Aaron, Lin, Keng-Han, Litterman, Nadia K., Luff, Marie K., McCreight, Jey C., McIntyre, Matthew H., McManus, Kimberly F., Mountain, Joanna L., Mozaffari, Sahar V., Nandakumar, Priyanka, Noblin, Elizabeth S., Northover, Carrie A. M., O���Connell, Jared, Petrakovitz, Aaron A., Pitts, Steven J., Poznik, G. David, Sathirapongsasuti, J. Fah, Shastri, Anjali J., Shelton, Janie F., Tian, Chao, Tung, Joyce Y., Tunney, Robert J., Vacic, Vladimir, Wang, Xin, Zare, Amir S., Kashyap, Purna, Chang, Lin, Mayer, Emeran, Heitkemper, Margaret, Sayuk, Gregory S., Ringel-Kulka, Tamar, Ringel, Yehuda, Chey, William D., Eswaran, Shanti, Merchant, Juanita L., Shulman, Robert J., Bujanda, Luis, Garcia-Etxebarria, Koldo, Dlugosz, Aldona, Lindberg, Greger, Schmidt, Peter T., Karling, Pontus, Ohlsson, Bodil, Walter, Susanna, Faresj��, ��shild O., Simren, Magnus, Halfvarson, Jonas, Portincasa, Piero, Barbara, Giovanni, Usai-Satta, Paolo, Neri, Matteo, Nardone, Gerardo, Cuomo, Rosario, Galeazzi, Francesca, Bellini, Massimo, Latiano, Anna, Houghton, Lesley, Jonkers, Daisy, Kurilshikov, Alexander, Weersma, Rinse K., Netea, Mihai, Tesarz, Jonas, Gauss, Annika, Goebel-Stengel, Miriam, Andresen, Viola, Frieling, Thomas, Pehl, Christian, Schaefert, Rainer, Niesler, Beate, Lieb, Wolfgang, Hanevik, Kurt, Langeland, Nina, Wensaas, Knut-Arne, Litleskare, Sverre, Gabrielsen, Maiken E., Thomas, Laurent, Thijs, Vincent, Lemmens, Robin, Van Oudenhove, Lukas, Wouters, Mira, Eijsbouts C., Zheng T., Kennedy N.A., Bonfiglio F., Anderson C.A., Moutsianas L., Holliday J., Shi J., Shringarpure S., Agee M., Aslibekyan S., Auton A., Bell R.K., Bryc K., Clark S.K., Elson S.L., Fletez-Brant K., Fontanillas P., Furlotte N.A., Gandhi P.M., Heilbron K., Hicks B., Hinds D.A., Huber K.E., Jewett E.M., Jiang Y., Kleinman A., Lin K.-H., Litterman N.K., Luff M.K., McCreight J.C., McIntyre M.H., McManus K.F., Mountain J.L., Mozaffari S.V., Nandakumar P., Noblin E.S., Northover C.A.M., O'Connell J., Petrakovitz A.A., Pitts S.J., Poznik G.D., Sathirapongsasuti J.F., Shastri A.J., Shelton J.F., Tian C., Tung J.Y., Tunney R.J., Vacic V., Wang X., Zare A.S., Voda A.-I., Kashyap P., Chang L., Mayer E., Heitkemper M., Sayuk G.S., Ringel-Kulka T., Ringel Y., Chey W.D., Eswaran S., Merchant J.L., Shulman R.J., Bujanda L., Garcia-Etxebarria K., Dlugosz A., Lindberg G., Schmidt P.T., Karling P., Ohlsson B., Walter S., Faresjo A.O., Simren M., Halfvarson J., Portincasa P., Barbara G., Usai-Satta P., Neri M., Nardone G., Cuomo R., Galeazzi F., Bellini M., Latiano A., Houghton L., Jonkers D., Kurilshikov A., Weersma R.K., Netea M., Tesarz J., Gauss A., Goebel-Stengel M., Andresen V., Frieling T., Pehl C., Schaefert R., Niesler B., Lieb W., Hanevik K., Langeland N., Wensaas K.-A., Litleskare S., Gabrielsen M.E., Thomas L., Thijs V., Lemmens R., Van Oudenhove L., Wouters M., Farrugia G., Franke A., Hubenthal M., Abecasis G., Zawistowski M., Skogholt A.H., Ness-Jensen E., Hveem K., Esko T., Teder-Laving M., Zhernakova A., Camilleri M., Boeckxstaens G., Whorwell P.J., Spiller R., McVean G., D'Amato M., Jostins L., Parkes M., Eijsbouts, Chris [0000-0001-5179-0653], Anderson, Carl A. [0000-0003-1719-7009], Moutsianas, Loukas [0000-0001-5453-345X], Holliday, Joanne [0000-0003-4568-7320], Shringarpure, Suyash [0000-0001-6464-2668], Voda, Alexandru-Ioan [0000-0003-2974-6992], Farrugia, Gianrico [0000-0003-3473-5235], Hübenthal, Matthias [0000-0002-5956-3006], Abecasis, Gonçalo [0000-0003-1509-1825], Zawistowski, Matthew [0000-0002-3005-083X], Ness-Jensen, Eivind [0000-0001-6005-0729], Teder-Laving, Maris [0000-0002-5872-1850], Camilleri, Michael [0000-0001-6472-7514], Whorwell, Peter J. [0000-0002-5220-8474], Spiller, Robin [0000-0001-6371-4500], McVean, Gil [0000-0002-5012-4162], D’Amato, Mauro [0000-0003-2743-5197], Jostins, Luke [0000-0002-2475-3969], Parkes, Miles [0000-0002-6467-0631], Apollo - University of Cambridge Repository, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Eijsbouts, C., Zheng, T., Kennedy, N. A., Bonfiglio, F., Anderson, C. A., Moutsianas, L., Holliday, J., Shi, J., Shringarpure, S., Agee, M., Aslibekyan, S., Auton, A., Bell, R. K., Bryc, K., Clark, S. K., Elson, S. L., Fletez-Brant, K., Fontanillas, P., Furlotte, N. A., Gandhi, P. M., Heilbron, K., Hicks, B., Hinds, D. A., Huber, K. E., Jewett, E. M., Jiang, Y., Kleinman, A., Lin, K. -H., Litterman, N. K., Luff, M. K., Mccreight, J. C., Mcintyre, M. H., Mcmanus, K. F., Mountain, J. L., Mozaffari, S. V., Nandakumar, P., Noblin, E. S., Northover, C. A. M., O'Connell, J., Petrakovitz, A. A., Pitts, S. J., Poznik, G. D., Sathirapongsasuti, J. F., Shastri, A. J., Shelton, J. F., Tian, C., Tung, J. Y., Tunney, R. J., Vacic, V., Wang, X., Zare, A. S., Voda, A. -I., Kashyap, P., Chang, L., Mayer, E., Heitkemper, M., Sayuk, G. S., Ringel-Kulka, T., Ringel, Y., Chey, W. D., Eswaran, S., Merchant, J. L., Shulman, R. J., Bujanda, L., Garcia-Etxebarria, K., Dlugosz, A., Lindberg, G., Schmidt, P. T., Karling, P., Ohlsson, B., Walter, S., Faresjo, A. O., Simren, M., Halfvarson, J., Portincasa, P., Barbara, G., Usai-Satta, P., Neri, M., Nardone, G., Cuomo, R., Galeazzi, F., Bellini, M., Latiano, A., Houghton, L., Jonkers, D., Kurilshikov, A., Weersma, R. K., Netea, M., Tesarz, J., Gauss, A., Goebel-Stengel, M., Andresen, V., Frieling, T., Pehl, C., Schaefert, R., Niesler, B., Lieb, W., Hanevik, K., Langeland, N., Wensaas, K. -A., Litleskare, S., Gabrielsen, M. E., Thomas, L., Thijs, V., Lemmens, R., Van Oudenhove, L., Wouters, M., Farrugia, G., Franke, A., Hubenthal, M., Abecasis, G., Zawistowski, M., Skogholt, A. H., Ness-Jensen, E., Hveem, K., Esko, T., Teder-Laving, M., Zhernakova, A., Camilleri, M., Boeckxstaens, G., Whorwell, P. J., Spiller, R., Mcvean, G., D'Amato, M., Jostins, L., and Parkes, M.

Subjects
Male, Molecular Chaperone, Mood Disorder, 631/208/205/2138, Biology, 692/699/1503/1502/2071, Bioinformatics, Polymorphism, Single Nucleotide, Genetic pathways, 38/43, Irritable Bowel Syndrome, Cytoskeletal Protein, Genetics, medicine, Genetic predisposition, Aged, Anxiety Disorders, CD56 Antigen, Cell Adhesion Molecules, Cytoskeletal Proteins, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Guanine Nucleotide Exchange Factors, Homeodomain Proteins, Humans, Middle Aged, Molecular Chaperones, Mood Disorders, United Kingdom, Polymorphism, 692/699/476, Irritable bowel syndrome, Depression (differential diagnoses), article, Homeodomain Protein, Single Nucleotide, Guanine Nucleotide Exchange Factor, medicine.disease, Neuroticism, Biobank, Mood, Cell Adhesion Molecule, Anxiety, medicine.symptom, Anxiety Disorder, Human
Abstract

Funder: Kennedy Trust Rheumatology Research Prize Studentship, Funder: DFG Cluster of Excellence ���Precision Medicine in Chronic In-flammation��� (PMI; ID: EXC2167), Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: ���Ideas��� Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)); doi: https://doi.org/10.13039/100011199; Grant(s): 715772, Funder: NWO-VIDI grant 016.178.056, the Netherlands Heart Foundation CVON grant 2018-27, and NWO Gravitation grant ExposomeNL, Funder: Li Ka Shing Foundation (Li Ka Shing Foundation Limited); doi: https://doi.org/10.13039/100007421, Irritable bowel syndrome (IBS) results from disordered brain���gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain���gut interactions underlying IBS.

Published
2021

131. Functional variants in the sucrase–isomaltase gene associate with increased risk of irritable bowel syndrome

Author

Henström, Maria, Diekmann, Lena, Bonfiglio, Ferdinando, Hadizadeh, Fatemeh, Kuech, Eva-Maria, von Köckritz-Blickwede, Maren, Thingholm, Louise B, Zheng, Tenghao, Assadi, Ghazaleh, Dierks, Claudia, Heine, Martin, Philipp, Ute, Distl, Ottmar, Money, Mary E, Belheouane, Meriem, Heinsen, Femke-Anouska, Rafter, Joseph, Nardone, Gerardo, Cuomo, Rosario, Usai-Satta, Paolo, Galeazzi, Francesca, Neri, Matteo, Walter, Susanna, Simrén, Magnus, Karling, Pontus, Ohlsson, Bodil, Schmidt, Peter T, Lindberg, Greger, Dlugosz, Aldona, Agreus, Lars, Andreasson, Anna, Mayer, Emeran, Baines, John F, Engstrand, Lars, Portincasa, Piero, Bellini, Massimo, Stanghellini, Vincenzo, Barbara, Giovanni, Chang, Lin, Camilleri, Michael, Franke, Andre, Naim, Hassan Y, and DʼAmato, Mauro

Published
2018
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134. List of Contributors

Author

Ahmet Başaran, A., primary, Ardevol, Anna, additional, Areco, Vanessa, additional, Atay, Ahmet E., additional, Bacanlı, Merve, additional, Bañares, Rafael, additional, Başaran, Nurşen, additional, Bauer, Georg, additional, Bauer, John Anthony, additional, Blay, Mayte, additional, Bonnet, Mathilde, additional, Casillas-Ramírez, Araní, additional, Chakraborty, Raja, additional, Ciacci, Carolina, additional, Ciampi, Saverio A., additional, Clark, Alexander D., additional, Colín-González, Ana Laura, additional, Contreras-Zentella, Martha L., additional, Cordero-Pérez, Paula, additional, Dell’Agli, Mario, additional, Esen, Bennur, additional, Fernández-Iglesias, Anabel, additional, Fernández-Tomé, Samuel, additional, Fichna, Jakub, additional, Fonseca Goulart, Marília O., additional, Fumagalli, Marco, additional, Gagnière, Johan, additional, Garcia Pagan, Juan C., additional, Garrison, Davis E., additional, Giannone, Peter J., additional, Gokmen, Emel S., additional, Gracia-Sancho, Jordi, additional, Grattagliano, Ignazio, additional, He, Feng, additional, Hernández-Ledesma, Blanca, additional, Hernández-Muñoz, Rolando, additional, Hide, Diana, additional, Hsieh, Chia-Chien, additional, Jesudoss, Victor Antony Santiago, additional, Jiménez-Castro, Mónica B., additional, Joshi, Mandar S., additional, Kim, Hyeyoung, additional, Kim, Min-Hyun, additional, Klotz, Lars-Oliver, additional, Krishnan, Koyamangalath, additional, Lafoz, Erica, additional, Lemon, Virginia R., additional, Leung, Po Sing, additional, Li, Lin, additional, Marchionatti, Ana, additional, Marciano, Francesca, additional, Medina-Escobedo, Sandra G., additional, Miranda-Bautista, José, additional, Mosińska, Paula, additional, Moura, Fabiana A., additional, Nankervis, Craig A., additional, Olguín-Martínez, Marisela, additional, Palau, Victoria, additional, Peralta, Carmen, additional, Pérez, Adriana, additional, Pinent, Montserrat, additional, Portincasa, Piero, additional, Rodríguez, Valeria, additional, Russo, Ilaria, additional, Salaga, Maciej, additional, Salvadó, Josepa, additional, Sánchez-Sevilla, Lourdes, additional, Sangiovanni, Enrico, additional, Santamaría, Abel, additional, Schanbacher, Brandon, additional, Sen, Saikat, additional, Speckmann, Bodo, additional, Steinbrenner, Holger, additional, Stenger, Michael R., additional, Stone, Bill, additional, Subramanian, Partiban, additional, Sypert, David C., additional, Terra, Ximena, additional, Tolosa de Talamoni, Nori, additional, Tripathi, Dinesh M., additional, Vajro, Pietro, additional, Vaquero, Javier, additional, Venkatachalam, Karthikkumar, additional, Victor Antony Santiago, Sundari, additional, Vilaseca, Marina, additional, Volpe, Stella Lucia, additional, Xu, Zan, additional, and Zuo, Li, additional

Published
2017
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136. Effects of MBOAT7 polymorphism and steatosis on liver function assessed by methacetin breath test.

Author

Di Ciaula, Agostino, Bonfrate, Leonilde, Shanmugam, Harshitha, Weber, Susanne N., Krawczyk, Marcin, and Portincasa, Piero

Subjects
ACOUSTIC radiation force impulse imaging, NON-alcoholic fatty liver disease, HEPATIC fibrosis, BREATH tests, FATTY degeneration
Abstract

Background: MBOAT7 rs641738 variant is a risk factor for nonalcoholic fatty liver disease (NAFLD) and liver fibrosis, but the relationship between this polymorphism and early liver dysfunction remains uncertain. Methods: Eighty outpatients underwent blood analyses, liver imaging by ultrasound and acoustic radiation force impulse shear wave elastography and were genotyped for MBOAT7 (wild‐type [WT], rs641738 heterozygous or homozygous) polymorphism using TaqMan assays. Results: NAFLD was confirmed in 53 patients. Portal uptake and hepatocyte microsomal metabolization of (13C)‐methacetin were explored by measuring 13CO2 appearance in exhaled air. The distribution of the MBOAT7 genotypes was comparable in subjects with or without NAFLD. The majority of subjects with or without NAFLD had fibrosis ≤ F1 but decreased portal extraction of (13C)‐methacetin, i.e. 78.6% in homozygous, 45.0% in heterozygous and 46.2% in WT for the MBOAT7 variant. Both substrate extraction and microsomal metabolization were mostly defective in the homozygous carriers. The extraction efficiency from portal blood flow was minimal in subjects with both homozygous rs641738 polymorphism and NAFLD, as compared to those with WT/heterozygous polymorphism, with or without NAFLD. Conclusions: The homozygous MBOAT7 rs641738 polymorphism per se is associated with a reduced extraction efficiency of (13C)‐methacetin from the portal flow pointing to subclinical liver dysfunction independently from liver fibrosis. Liver steatosis worsens (13C)‐methacetin extraction efficiency. We urge to better explore the mechanisms of interaction between external factors and multiple gene polymorphisms (including MBOAT7), paving the road to primary prevention and novel therapeutic strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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137. Red Blood Cells (RBC) Deformability and Aggregability: Alterations in Alcoholism

Author

Palmieri, Vincenzo O., Cicco, Giuseppe, Minerva, Francesco, Portincasa, Piero, Grattagliano, Ignazio, Memeo, Vincenzo, Palasciano, Giuseppe, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Cicco, Giuseppe, editor, Bruley, Duane F., editor, Ferrari, Marco, editor, and Harrison, David K., editor

Published
2006
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138. The 'Hemolysis Model' for the Study of Cyto-Toxicity and Cyto-Protection by Bile Salts and Phospholipids

Author

Portincasa, Piero, Moschetta, Antonio, Petruzzelli, Michele, Vacca, Michele, Krawczyk, Marcin, Minerva, Francesco, Palmieri, Vincenzo O., Palasciano, Giuseppe, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Cicco, Giuseppe, editor, Bruley, Duane F., editor, Ferrari, Marco, editor, and Harrison, David K., editor

Published
2006
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140. Diverticular Inflammation and Complication Assessment classification, CODA score and fecal calprotectin in clinical assessment of patients with diverticular disease: A decision curve analysis

Author

Tursi, Antonio, Piovani, Daniele, Brandimarte, Giovanni, Mario, Francesco, Elisei, Walter, Picchio, Marcello, Allegretta, Leonardo, Annunziata, Maria Laura, Bafutto, Mauro, Bassotti, Gabrio, Bianco, Maria Antonia, Colucci, Raffaele, Conigliaro, Rita, Dumitrascu, Dan L., Escalante, Ricardo, Ferrini, Luciano, Forti, Giacomo, Franceschi, Marilisa, Graziani, Maria Giovanna, Lammert, Frank, Latella, Giovanni, Maconi, Giovanni, Compare, Debora, Nardone, Gerardo, Camara De Castro Oliveira, Lucia, Oliveira, Enio Chaves, Papa, Alfredo, Papagrigoriadis, Savvas, Pietrzak, Anna, Pontone, Stefano, Poskus, Tomas, Pranzo, Giuseppe, Reichert, Matthias Christian, Rodinò, Stefano, Regula, Jaroslaw, Scaccianoce, Giuseppe, Scaldaferri, Franco, Vassallo, Roberto, Zampaletta, Costantino, Zullo, Angelo, Spaziani, Erasmo, Bonovas, Stefanos, Danese, Silvio, Astegiano, Marco, Bachetti, Francesco, Baldassarre, Gianluca, Baldi, Fabio, Borsotti, Edoardo, Cassieri, Claudio, Cazzato, Alessia, Chiri, Stefania, Ciccone, Antonio, Damiani, Alberto, Colibus, Patrizia De, Faggiani, Roberto, Finocchiaro, Fabio, Fiorella, Serafina, Foschia, Francesca, Furfaro, Federica, Gallina, Sara, Giorgetti, Gian Marco, Grad, Simona, Grande, Giuseppe, Grandolfo, Antonio, Lai, Maria Antonia, Lecca, Piera Giuseppina, Lisi, Daniele, Lopetuso, Loris Riccardo, Penna, Antonio, Pigò, Flavia, Portincasa, Piero, Rizzatti, Giannenrico, Rizzo, Giovanni Luca, Scanni, Stefania, Schiffino, Luigi, Stundiene, Ieva, Tesoriere, Antonino, Urgesi, Riccardo, and Usai, Paolo

Abstract

The Diverticular Inflammation and Complication Assessment (DICA) classification and the Combined Overview on Diverticular Assessment (CODA) were found to be effective in predicting the outcomes of Diverticular Disease (DD). We ascertain whether fecal calprotectin (FC) can further aid in improving risk stratification. A three‐year international, multicentre, prospective cohort study was conducted involving 43 Gastroenterology and Endoscopy centres. Survival methods for censored observations were used to estimate the risk of acute diverticulitis (AD) in newly diagnosed DD patients according to basal FC, DICA, and CODA. The net benefit of management strategies based on DICA, CODA and FC in addition to CODA was assessed with decision curve analysis, which incorporates the harms and benefits of using a prognostic model for clinical decisions. At the first diagnosis of diverticulosis/DD, 871 participants underwent FC measurement. FC was associated with the risk of AD at 3 years (HR per each base 10 logarithm increase: 3.29; 95% confidence interval, 2.13–5.10) and showed moderate discrimination (c‐statistic: 0.685; 0.614–0.756). DICA and CODA were more accurate predictors of AD than FC. However, FC showed high discrimination capacity to predict AD at 3 months, which was not maintained at longer follow‐up times. The decision curve analysis comparing the combination of FC and CODA with CODA alone did not clearly indicate a larger net benefit of one strategy over the other. FC measurement could be used as a complementary tool to assess the immediate risk of AD. In all other cases, treatment strategies based on the CODA score alone should be recommended.

Published
2023
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