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1,057 results on '"QIU Xiaoyan"'

106. Five impurities in posaconazole: detection, genotoxicity prediction and action-mechanism analysis.

Author

Li, Fangzhen, Yang, Jian, Zheng, Kangle, Liu, Weifeng, Qiu, Xiaoyan, and Luo, Hengzhen

Subjects
GENETIC toxicology, MUTAGENS, GRADIENT elution (Chromatography), ACID solutions, AQUEOUS solutions
Abstract

Genotoxic impurities are a class of highly potent mutagenic substances that typically needs to be controlled down to low ppm level in pharmaceuticals. A novel LC-MS/MS limit test method (single impurity ≤16.7 ppm) for detecting five impurities in Posaconazole has been established and partially validated. The chromatographic separation of analytes was conducted on an YMC-Triart C18 column and gradient elution was performed with 0.1% formic acid aqueous solution and acetonitrile as mobile phase A and B, respectively. Five impurities were carried out in ESI+ and MRM with the following mass transition pairs: m/z 390.2→296.2 for BSKZ029, m/z 300.4→136.2 for BSKZ117, m/z 207.0→162.2 for BSKZ135, m/z 209.0→91.0 for BSKZ155 and m/z 499.1→258.1 for BSKZ160. The established method exhibited good specificity, well robustness and high sensitivity with the LOD and LOQ was 1.34-1.56 ng/mL and 4.01-4.69 ng/mL, respectively. The genotoxicity of these impurities were evaluated by two (Q)SAR prediction methodologies, and results showed that BSKZ135 and BSKZ029 exhibited no genotoxicity, while BSKZ155, BSKZ117 and BSKZ160 possessed potent mutagenicity risk. Furthermore, the possible action-mechanisms of which were analyzed and proposed. This study has instructive significance to the analysis and genotoxicity research of genotoxic impurities, and also provides technical support for the supervision of the drug administration. [ABSTRACT FROM AUTHOR]

Published
2024
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107. Five genes identified as prognostic markers for colorectal cancer through the integration of genome-wide association study and expression quantitative trait loci data.

Author

Zhang, Cuizhen, Huang, Wenjie, Niu, Wanjie, Yang, Huiying, Zheng, Yingyi, Gao, Xuan, and Qiu, Xiaoyan

Abstract

Background: Colorectal cancer (CRC) is a prominent form of cancer globally, ranking second in terms of prevalence and serving as a leading cause of cancer-related deaths, but the underlying biological interpretation remains largely unknown. Methods: We used the summary data-based Mendelian randomization method to integrate CRC genome-wide association studies (ncase = 7062; ncontrol = 195,745) and expression quantitative trait loci summary data in peripheral whole blood (Consortium for Architecture of Gene Expression: n = 2765; Genotype-Tissue Expression [v8]: n = 755) and colon tissue (colon-transverse: n = 406; colon-sigmoid: n = 373) and identified related genes. Results: Genes ABTB1, CYP21A2, NLRP1, PHKG1 and PIP5K1C have emerged as significant prognostic markers for CRC patient survival. Functional analysis revealed their involvement in cancer cell migration and invasion mechanisms, providing valuable insights for the development of future anti-CRC drugs. Conclusion: We successfully identified five CRC risk genes, providing new insights and research directions for the effective mechanisms of CRC. Summary points The primary objective of our study was to detect functional genes and regulatory elements in colorectal cancer (CRC) by combining genome-wide association study summary data with expression quantitative trait loci data. Through the utilization of the summary data-based Mendelian randomization method, we successfully integrated CRC genome-wide association study and expression quantitative trait loci datasets, resulting in the identification of 135 risk genes associated with CRC. Comprehensive Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed that these 135 risk genes are significantly enriched in regulatory pathways crucial for cancer cell growth, metabolic processes and immune response. By combining data from colon adenocarcinoma and rectum adenocarcinoma cohorts within The Cancer Genome Atlas database, we discovered that among the 135 risk genes, ABTB1, CYP21A2, NLRP1, PHKG1 and PIP5K1C are strongly associated with the survival outcomes of CRC patients. Notably, the CYP21A2 gene exhibited a positive correlation with pathways involved in the proliferation and migration of CRC, underscoring its potential role as a susceptibility gene and a promising target for clinical intervention in CRC. These results provide important insights into the molecular mechanisms of CRC genomics and provide potential targets for treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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121. Supplementary Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness

Author

Huang, Xinmei, primary, Zhang, Shenghua, primary, Tang, Jingshu, primary, Tian, Tian, primary, Pan, Yilin, primary, Wu, Lina, primary, Zhang, Jingxuan, primary, Liu, Yang, primary, Huang, Jing, primary, Dai, Hui, primary, Xu, Weiyan, primary, Zhang, Youhui, primary, Chen, Jinfeng, primary, Cao, Mengshu, primary, Zhang, Liang, primary, and Qiu, Xiaoyan, primary

Published
2023
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122. Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness

Author

Huang, Xinmei, primary, Zhang, Shenghua, primary, Tang, Jingshu, primary, Tian, Tian, primary, Pan, Yilin, primary, Wu, Lina, primary, Zhang, Jingxuan, primary, Liu, Yang, primary, Huang, Jing, primary, Dai, Hui, primary, Xu, Weiyan, primary, Zhang, Youhui, primary, Chen, Jinfeng, primary, Cao, Mengshu, primary, Zhang, Liang, primary, and Qiu, Xiaoyan, primary

Published
2023
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123. A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness

Author

Huang, Xinmei, primary, Zhang, Shenghua, additional, Tang, Jingshu, additional, Tian, Tian, additional, Pan, Yilin, additional, Wu, Lina, additional, Zhang, Jingxuan, additional, Liu, Yang, additional, Huang, Jing, additional, Dai, Hui, additional, Xu, Weiyan, additional, Zhang, Youhui, additional, Chen, Jinfeng, additional, Cao, Mengshu, additional, Zhang, Liang, additional, and Qiu, Xiaoyan, additional

Published
2023
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127. Supplementary Figure 1 from CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis

Author

Wang, Yu, primary, Li, Jisheng, primary, Cui, Yan, primary, Li, Ting, primary, Ng, Ka Man, primary, Geng, Hua, primary, Li, Henan, primary, Shu, Xing-sheng, primary, Li, Hongyu, primary, Liu, Wei, primary, Luo, Bing, primary, Zhang, Qian, primary, Mok, Tony Shu Kam, primary, Zheng, Wei, primary, Qiu, Xiaoyan, primary, Srivastava, Gopesh, primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Chan, Anthony T.C., primary, Ma, Dalong, primary, Tao, Qian, primary, and Han, Wenling, primary

Published
2023
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128. Data from CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis

Author

Wang, Yu, primary, Li, Jisheng, primary, Cui, Yan, primary, Li, Ting, primary, Ng, Ka Man, primary, Geng, Hua, primary, Li, Henan, primary, Shu, Xing-sheng, primary, Li, Hongyu, primary, Liu, Wei, primary, Luo, Bing, primary, Zhang, Qian, primary, Mok, Tony Shu Kam, primary, Zheng, Wei, primary, Qiu, Xiaoyan, primary, Srivastava, Gopesh, primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Chan, Anthony T.C., primary, Ma, Dalong, primary, Tao, Qian, primary, and Han, Wenling, primary

Published
2023
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129. Supplementary Figures Legends 1-3 from CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis

Author

Wang, Yu, primary, Li, Jisheng, primary, Cui, Yan, primary, Li, Ting, primary, Ng, Ka Man, primary, Geng, Hua, primary, Li, Henan, primary, Shu, Xing-sheng, primary, Li, Hongyu, primary, Liu, Wei, primary, Luo, Bing, primary, Zhang, Qian, primary, Mok, Tony Shu Kam, primary, Zheng, Wei, primary, Qiu, Xiaoyan, primary, Srivastava, Gopesh, primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Chan, Anthony T.C., primary, Ma, Dalong, primary, Tao, Qian, primary, and Han, Wenling, primary

Published
2023
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131. Supplementary Figure 3 from CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis

Author

Wang, Yu, primary, Li, Jisheng, primary, Cui, Yan, primary, Li, Ting, primary, Ng, Ka Man, primary, Geng, Hua, primary, Li, Henan, primary, Shu, Xing-sheng, primary, Li, Hongyu, primary, Liu, Wei, primary, Luo, Bing, primary, Zhang, Qian, primary, Mok, Tony Shu Kam, primary, Zheng, Wei, primary, Qiu, Xiaoyan, primary, Srivastava, Gopesh, primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Chan, Anthony T.C., primary, Ma, Dalong, primary, Tao, Qian, primary, and Han, Wenling, primary

Published
2023
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132. Supplementary Figure 2 from CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis

Author

Wang, Yu, primary, Li, Jisheng, primary, Cui, Yan, primary, Li, Ting, primary, Ng, Ka Man, primary, Geng, Hua, primary, Li, Henan, primary, Shu, Xing-sheng, primary, Li, Hongyu, primary, Liu, Wei, primary, Luo, Bing, primary, Zhang, Qian, primary, Mok, Tony Shu Kam, primary, Zheng, Wei, primary, Qiu, Xiaoyan, primary, Srivastava, Gopesh, primary, Yu, Jun, primary, Sung, Joseph J.Y., primary, Chan, Anthony T.C., primary, Ma, Dalong, primary, Tao, Qian, primary, and Han, Wenling, primary

Published
2023
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138. B-Cell Receptor Features and Database Establishment in Recovered COVID-19 Patients by Combining 5'-RACE with PacBio Sequencing

Author

Zhu, Zhu, primary, Wang, Pingzhang, primary, Jia, Xiaodong, primary, Yu, Meng, primary, Yan, Huige, primary, Liu, Lei, primary, Liu, Wanbing, primary, Zheng, Yaqiong, primary, Kou, Guomei, primary, Wang, Jie, primary, Xu, Weiyan, primary, Huang, Jing, primary, Duan, Fugang, primary, Lu, Fengmin, primary, Fu, Ning, primary, Zhang, Ning, primary, Lu, Yingying, primary, Dai, Hui, primary, Zheng, Shangen, primary, and Qiu, Xiaoyan, primary

Published
2023
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141. Cancer-cell-derived sialylated IgG as a novel biomarker for predicting poor pathological response to neoadjuvant therapy and prognosis in pancreatic cancer

Author

Cui, Ming, primary, Shoucair, Sami, additional, Liao, Quan, additional, Qiu, Xiaoyan, additional, Kinny-Köster, Benedict, additional, Habib, Joseph R., additional, Ghabi, Elie M., additional, Wang, Junke, additional, Shin, Eun Ji, additional, Leng, Sean X., additional, Ali, Syed Z., additional, Thompson, Elizabeth D., additional, Zimmerman, Jacquelyn W., additional, Shubert, Christopher R., additional, Lafaro, Kelly J., additional, Burkhart, Richard A., additional, Burns, William R., additional, Zheng, Lei, additional, He, Jin, additional, Zhao, Yupei, additional, Wolfgang, Christopher L., additional, and Yu, Jun, additional

Published
2023
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