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In recent years, breast cancer has become one of the biggest threats to women's health, accounting for the majority of cancer deaths among women. Because early treatment of breast cancer has a great effect on the recovery of breast cancer, the diagnosis of breast cancer is particularly important. Machine learning, as the most popular method, is also used for model construction in this field. This study is based on data from breast tumors, which contain 10 morphological features of breast tumor nucleus. In this study, homogenization, standardization and feature selection were used to process the data and KNN algorithm was used to construct the classification prediction model, with principal component analysis (PCA) used to optimize the model. Finally, the original 30 variables were reduced to 3 variables and the model parameters were adjusted in order to achieve the best model with the accuracy of 98.54%. The final model achieves the highest operating efficiency and accuracy. In this study, through the visualization of PCA and the comparison of different models, the classification effect of the final model can be the best. This model can be applied to the clinical diagnosis of breast cancer patients, which is helpful to the early treatment efficiency and greatly reduce the mortality of breast cancer patients

Diaphragm compressors have become the primary source of on-site hydrogen compression for hydrogen fuelling stations around the world. The most common hydrogen-compressor-failure mechanism has been identified as diaphragm fracture due to low tensile strength and poor surface properties. In this study, a new type of GH4169 diaphragm with high yield strength and low surface roughness was fabricated. Microstructures, tensile behaviours and surface properties of the specimens were characterized by using scanning electron microscopy, an electronic universal testing machine and atomic force microscopy, respectively. The evolution of the γ′′ and γ′ phases with temperature has been examined. Both γ′′ and γ′ phases were precipitant-strengthened phases for GH4169 and the volume and size of γ′′ and γ′ phases increase with ageing time. In addition, the γ′′ phase is the main strengthening phase and γ′ is the supportive strengthening phase. Tensile strength was increased due to the strengthening phases at the cost of ductility. The roughness of the diaphragm could reach an arithmetic average roughness (Ra) of 0.1 μ m by applying a cooling-assisted polishing process. This work improves the reliability and reduces the auxiliary steps and down-time for diaphragm compressors.

A novel strategy for the synthesis of conductive shear thickening fluids (STFs) which manifest both shear thickening behavior and strain-sensing properties.

Proper selection of the operating conditions of molten carbonate fuel cells (MCFCs) can not only effectively improve the efficiency of power generation, but also reduce carbon emissions and help achieve the great goal of “carbon neutrality”.

Phosphors that exhibit tunable broadband emissions are highly desired in multi-functional LEDs, including pc-WLEDs and pc-NIR LEDs.

Silicon (Si) is considered a promising anode material for rechargeable lithium-ion batteries (LIBs) due to its high theoretical capacity, low working potential, and safety features. However, the practical use of Si-based anodes is hampered by their huge volume expansion during the process of lithiation/delithiation, and they have relatively low intrinsic electronic conductivity, therefore seriously restricting their application in energy storage. Here, we propose a facile approach to directly transform siliceous biomass (bamboo leaves) into a porous carbon skeleton-wrapped Si nanodot architecture through a partial oxidization strategy and magnesium thermal reaction to obtain a high Si nanodot component composite (denoted as Si/C-O). With the synergistic effect of the porous carbon skeleton structure and uniformly dispersed Si nanodots, the Si/C-O composite anode with a stable structure that can avoid pulverization and accommodate volume expansion during cycling is fabricated. As expected, the biomass-converted Si/C-O anode not only presents a high Si component (59.7 wt %) by TGA but also exhibits an excellent capacity of 1013 mAh g

Bmp5 mutation can lead to microtia in mice models; however, its underlying mechanism is unclear. We analyzed circular RNA (circRNA) expression changes and associated gene regulation during embryonic development of the mouse's external ear after a point mutation occurred naturally in the BMP5 gene. The outer ear tissues of BMP5 short-eared mouse model embryos at embryonic day (E) 15.5 and E17.5 were subjected to RNA sequencing. Changes in the circRNA expression profile were detected using find_circ and the CiRi2 software. Differentially expressed circRNAs were annotated by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. The circRNA expression profile differed between wild-type and mutant mouse embryos. At E15.5, differentially expressed RNAs were involved in the Hippo signaling pathway, whereas those at E17.5 were associated with stem cell pluripotency. Therefore, circRNA is involved in regulating embryonic external ear development, thus providing a basis for studying the biological aspect of its regulation.

A low-temperature sintering strategy was realized for preparing 0.21Bi(Ni0.5Ti0.5)O3-0.05BiFeO3-0.74Pb(Zr0.5Ti0.5)O3 (0.21BNT-0.05BF-0.74PZT) ceramics by conventional ceramic processing by adding low melting point BiFeO3 and additional sintering aid LiBO2. Pure perovskite 0.21BNT-0.05BF-0.74PZT ceramics are prepared at relatively low sintering temperatures, and their structure presents tetragonal distortion that is affected slightly by the sintering temperature. The 1030 °C sintered samples have high densification accompanied by relatively large grains. All ceramics have excellent dielectric performance with a relatively high temperature of dielectric constant maximum, and present an apparent relaxation characteristic. A narrow sintering temperature range exists in the 0.21BNT-0.05BF-0.74PZT system, and the 1030 °C sintered 0.21BNT-0.05BF-0.74PZT ceramics exhibit overall excellent electrical performance. The high-temperature conductivity can be attributed to the oxygen vacancies’ conduction produced by the evaporation of Pb and Bi during sintering revealed by energy dispersive X-ray measurement.

Disc herniation have shown confirmed biomechanical influence on close neighboring vertebrae but the impact on distant neighboring vertebrae remains unknown. After matching age and gender at a single site, we retrospectively evaluated 516 patients with lumbar disc herniation(LDH group)and an equal number of healthy people༈Control group༉to determine the effect of disc herniation on vertebral axial rotation (VAR) in lumbar spine, and explore potential risk factors for VAR in patients with (LDH). Each lumbar spine vertebra's degree of axial rotation was evaluated using the Nash-Moe index. The prevalence of VAR of lumbar spine is greater in LDH group than in Control group (65.7% vs 46.7%, P༜0.001). L2 vertebra in LDH group had the highest frequency of VAR (49.5%), followed by L1(45.1%), and from L3 to L5༈33.6%,8.9%,3.1%༉. The Control group also displayed a similar pattern (L2,39.8%; L1,34.6%; L3,23.2%; L4,3.1%; L5,0.8%). Disc herniation was associated with a higher incidence of VAR in both close and distant neighboring vertebrae. Multivariate analysis showed that age is an independent risk factor for VAR, (OR = 1.245, 95% CI [1.111,1.394], P༜0.001), while symptoms duration and back pain not.

Ultrafine Si embedded SiO2 nanowires have been prepared by thermal evaporation using Pt catalyst. The ultrafine Si embedded SiO2 nanowires with a diameter of about 10 nm were grown in-situ on the Si substrate, conforming to a vapor-liquid-solid growth mechanism. On account of the existence of the quantum confinement effect, the absorption edge of the ultrafine Si embedded SiO2 nanowires is slightly larger. The photoluminescence result reveals a blue shift in the ultrafine nanowires, which may be due to the macroscopic behavior of the sample becomes more relevant and the typical surface plasmon absorption band appears. The Pt-related light emission characteristics will enable the development of nanowires in the field of optoelectronics.

The binding between ADA-07 and TOPK is illustrated by Maestro in the Schrödinger Suite. The binding model shows that the hydrogen atom (white color) of glycine binds with oxygen (red color) and nitrogen (blue color) of ADA-07 to form hydrogen bonds. The oxygen atom of glycine binds with hydrogen of ADA-07 to form a hydrogen bond.

Lung cancer is the leading cause of cancer-related death worldwide. However, promising agents for lung cancer prevention are still very limited. Identification of preventive targets and novel effective preventive agents is urgently needed for clinical applications. In this study, we found that fluvastatin targeted 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGCR), which a rate-limiting enzyme in the mevalonate pathway, and inhibited non–small cell lung cancer (NSCLC) tumorigenesis. Initially, we demonstrated that HMGCR is overexpressed in human lung adenocarcinoma tissues compared with normal tissues. Knockdown of HMGCR in NSCLC cells attenuated growth and induced apoptosis in vitro and in vivo. Furthermore, we found that fluvastatin, an inhibitor of HMGCR, suppressed NSCLC cell growth and induced apoptosis. Intriguingly, fluvastastin functions by inhibiting the HMGCR-driven Braf/MEK/ERK1/2 and Akt signaling pathways. Notably, fluvastatin attenuated tumor growth in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis and in a patient-derived xenograft lung tumor model. Overall, our findings suggest that fluvastatin might be promising chemopreventive or potential therapeutic drug against NSCLC tumorigenesis, providing hope for rapid clinical translation.

ADA-07 synthesis, MS analysis and cytotoxicity assays.

Cumulative exposure to solar ultraviolet (SUV) irradiation is regarded as the major etiologic factor in the development of skin cancer. The activation of the MAPK cascades occurs rapidly and is vital in the regulation of SUV-induced cellular responses. The T-LAK cell–originated protein kinase (TOPK), an upstream activator of MAPKs, is heavily involved in inflammation, DNA damage, and tumor development. However, the chemopreventive and therapeutic effects of specific TOPK inhibitors in SUV-induced skin cancer have not yet been elucidated. In the current study, ADA-07, a novel TOPK inhibitor, was synthesized and characterized. Pull-down assay results, ATP competition, and in vitro kinase assay data revealed that ADA-07 interacted with TOPK at the ATP-binding pocket and inhibited its kinase activity. Western blot analysis showed that ADA-07 suppressed SUV-induced phosphorylation of ERK1/2, p38, and JNKs and subsequently inhibited AP-1 activity. Importantly, topical treatment with ADA-07 dramatically attenuated tumor incidence, multiplicity, and volume in SKH-1 hairless mice exposed to chronic SUV. Our findings suggest that ADA-07 is a promising chemopreventive or potential therapeutic agent against SUV-induced skin carcinogenesis that acts by specifically targeting TOPK. Mol Cancer Ther; 16(9); 1843–54. ©2017 AACR.

Figure S1. OPN4 expression is upregulated in human lung adenocarcinoma. Figure S2. Knockdown of OPN4 inhibits cells growth and induces cells apoptosis in H441 and A549 cells. Figure S3. Loss OPN4 suppresses urethane-induced lung carcinogenesis. Figure S4. Effects of OPN4 antagonist AE 51310 on normal lung cells growth. Figure S5. OPN4 antagonist inhibits tumor growth in lung PDX mouse model.

Supplementary Figure Legends

ADA-07 significantly suppresses SUV-induced skin carcinogenesis in SKH-1 hairless mice (early-stage prevention). A, average body weight of SKH-1 hairless mice. Mice were weighed once a week until the end of the study at week 28. B, external appearance of tumors. SKH-1 hairless mice were treated as described in Materials and Methods. The mice in the control groups (n = 9) received no vehicle/no SUV (n = 3), vehicle/no SUV (n = 3), or 1 mg ADA-07/no SUV (n = 3), respectively. The mice in the SUV treated group received SUV only (n = 12) and the mice in the vehicle/SUV-treated group (n = 12) were treated with oil-in-water emulsion cream before SUV exposure. The mice in the 0.1 mg/SUV or 1 mg/SUV groups (n = 12 each) received treatment with ADA-07 (0.1 or 1 mg, respectively) before SUV exposure. The frequency of irradiation was set at 3 times a week for 15 weeks. The respective doses of oil-in-water emulsion cream or ADA-07 were applied topically to the dorsal area. Tumor incidence and multiplicity were recorded weekly until the end of the experiment at week 28.