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107. Atrioventricular Synchronous Pacing Using a Leadless Ventricular Pacemaker:Results From the MARVEL 2 Study

Author

Steinwender, Clemens, Khelae, Surinder Kaur, Garweg, Christophe, Chan, Joseph Yat Sun, Ritter, Philippe, Johansen, Jens Brock, Sagi, Venkata, Epstein, Laurence M, Piccini, Jonathan P, Pascual, Mario, Mont, Lluis, Sheldon, Todd, Splett, Vincent, Stromberg, Kurt, Wood, Nicole, and Chinitz, Larry

Subjects
Science & Technology, Cardiac & Cardiovascular Systems, AV block, ATRIAL, Cardiovascular System & Cardiology, cardiovascular diseases, atrioventricular synchrony, Life Sciences & Biomedicine, leadless pacemaker, TERM-FOLLOW-UP
Abstract

OBJECTIVES: This study reports on the performance of a leadless ventricular pacemaker with automated, enhanced accelerometer-based algorithms that provide atrioventricular (AV) synchronous pacing. BACKGROUND: Despite many advantages, leadless pacemakers are currently only capable of single-chamber ventricular pacing. METHODS: The prospective MARVEL 2 (Micra Atrial tRacking using a Ventricular accELerometer 2) study assessed the performance of an automated, enhanced accelerometer-based algorithm downloaded to the Micra leadless pacemaker for up to 5 h in patients with AV block. The primary efficacy objective was to demonstrate the superiority of the algorithm to provide AV synchronous (VDD) pacing versus VVI-50 pacing in patients with sinus rhythm and complete AV block. The primary safety objective was to demonstrate that the algorithm did not result in pauses or heart rates of >100 beats/min. RESULTS: Overall, 75 patients from 12 centers were enrolled; an accelerometer-based algorithm was downloaded to their leadless pacemakers. Among the 40 patients with sinus rhythm and complete AV block included in the primary efficacy objective analysis, the proportion of patients with ≥70% AV synchrony at rest was significantly greater with VDD pacing than with VVI pacing (95% vs. 0%; p

Published
2020
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109. Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in Collaboration with the European Heart Rhythm Association

Author

Vardas, Panos E., Auricchio, Angelo, Blanc, Jean-Jacques, Daubert, Jean-Claude, Drexler, Helmut, Ector, Hugo, Gasparini, Maurizio, Linde, Cecilia, Morgado, Francisco Bello, Oto, Ali, Sutton, Richard, Trusz-Gluza, Maria, Vahanian, Alec, Camm, John, De Caterina, Raffaele, Dean, Veronica, Dickstein, Kenneth, Funck-Brentano, Christian, Filippatos, Gerasimos, Hellemans, Irene, Kristensen, Steen Dalby, McGregor, Keith, Sechtem, Udo, Silber, Sigmund, Tendera, Michal, Widimsky, Petr, Zamorano, José Luis, Priori, Silvia G., Blomström-Lundqvist, Carina, Brignole, Michele, Terradellas, Josep Brugada, Castellano, Perez, Cleland, John, Farre, Jeronimo, Fromer, Martin, Le Heuzey, Jean-Yves, Lip, Gregory YH, Merino, Jose Luis, Montenero, Annibale Sandro, Ritter, Philippe, Schalij, Martin Jan, and Stellbrink, Christopher

Published
2007

111. Editorial

Author

Ritter, Philippe and Sutton, Richard

Published
2006

112. Great News!

Author

Ritter, Philippe and Priori, Silvia G

Published
2006

113. Impact of paced left ventricular dyssynchrony on left ventricular reverse remodeling after cardiac resynchronization therapy

Author

Gauthey, Anais, Gauthey, Anais, Willemen, Erik, Lumens, Joost, Ploux, Sylvain, Bordachar, Pierre, Ritter, Philippe, Prinzen, Frits W., Lejeune, Sibille, Pouleur, Anne-Catherine, Garnir, Quentin, Marchandise, Sebastien, Scavee, Christophe, Wauters, Aurelien, De Waroux, Jean-Benoit Le Polain, Gauthey, Anais, Gauthey, Anais, Willemen, Erik, Lumens, Joost, Ploux, Sylvain, Bordachar, Pierre, Ritter, Philippe, Prinzen, Frits W., Lejeune, Sibille, Pouleur, Anne-Catherine, Garnir, Quentin, Marchandise, Sebastien, Scavee, Christophe, Wauters, Aurelien, and De Waroux, Jean-Benoit Le Polain

Abstract

Introduction We investigated whether pacing-induced electrical dyssynchrony at the time of cardiac resynchronization therapy (CRT) device implantation was associated with chronic CRT response. Methods and Results We included a total of 69 consecutive heart failure patients who received a CRT device. Left (LVp-RVs) and right (RVp-LVs) pacing-induced interlead delays were measured intraoperatively and used to determine if there was paced left ventricular (LV) dyssynchrony, defined as present when LVp-RVs is larger than RVp-LVs. CRT response was defined as a reduction in LV end-systolic volume >= 15%, 6 months after implantation. Paced left ventricular dyssynchrony (PLVD) was associated with ischemic cardiomyopathy (ICM) (chi(2): 8; P = .005) but not with QRS morphology nor with pacing lead positions. In a univariate analysis, PLVD (odds ratio [OR], 6.53; 95% confidence interval [CI], 2.2-18.9; P = .001), atypical left bundle branch block (LBBB) (OR, 3.3; 95% CI, 1.2-9.4; P = .022), and ICM (OR, 5.2; 95% CI, 1.6-17; P = .006) were associated with nonresponse. In a multivariate analysis, both PLVD (OR, 9.74; 95% CI, 2.8-33.9; P <.0001) and atypical LBBB (OR, 5.6; 95% CI, 1.5-20.3; P = .009) were independently associated with nonresponse. Adding PLVD to a model based on QRS morphology provided a significant and meaningful incremental value to predict LV reverse remodeling after CRT (chi(2) to enter: 8; P <.005). Computer simulations corroborate these findings by showing that, while intrinsic electrical dyssynchrony is a prerequisite, the level of pacing-induced dyssynchrony modulates acute CRT response. Conclusion In addition to the intrinsic electrical substrate, PLVD is strongly associated with less LV reverse remodeling, demonstrating that measuring the electrical substrate during pacing has additional value for prediction of CRT response in an already well-selected patient population.

Published
2020

117. Impact of paced left ventricular dyssynchrony on left ventricular reverse remodeling after cardiac resynchronization therapy

Author

Gauthey, Anaïs, primary, Willemen, Erik, additional, Lumens, Joost, additional, Ploux, Sylvain, additional, Bordachar, Pierre, additional, Ritter, Philippe, additional, Prinzen, Frits W., additional, Lejeune, Sibille, additional, Pouleur, Anne‐Catherine, additional, Garnir, Quentin, additional, Marchandise, Sébastien, additional, Scavée, Christophe, additional, Wauters, Aurélien, additional, and Waroux, Jean‐Benoit, additional

Published
2020
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118. Atrioventricular Synchronous Pacing Using a Leadless Ventricular Pacemaker

Author

Steinwender, Clemens, primary, Khelae, Surinder Kaur, additional, Garweg, Christophe, additional, Chan, Joseph Yat Sun, additional, Ritter, Philippe, additional, Johansen, Jens Brock, additional, Sagi, Venkata, additional, Epstein, Laurence M., additional, Piccini, Jonathan P., additional, Pascual, Mario, additional, Mont, Lluis, additional, Sheldon, Todd, additional, Splett, Vincent, additional, Stromberg, Kurt, additional, Wood, Nicole, additional, and Chinitz, Larry, additional

Published
2020
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119. Trigger and Substrate Share A Common Location In Human VF

Author

HAÏSSAGUERRE, Michel, HOCINI, Meleze, PUYO, Stéphane, CHENITI, Ghassen, DUCHATEAU, Josselin, DENIS, Arnaud, COCHET, Hubert, MEO, Marianna, KITAMURA, Takeshi, TAKIGAWA, Masateru, FRONTERA, Antonio, VLACHOS, Konstantinos George, MASSOULLIÉ, Grégoire, LAM, Anna, BOURIER, Felix, PAMBRUN, Thomas, WELTE, Nicolas, DERVAL, Nicolas, AMRAOUI, Sana, KLOTZ, Nicolas, SACHER, Fréderic, BORDACHAR, Pierre, PLOUX, Sylvain, RITTER, Philippe, JAÏS, Pierre, VIGMOND, Edward J., POTSE, Mark, WALTON, Richard D., DUBOIS, Rémi, BERNUS, Olivier, IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de cardiologie, CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Université de Bordeaux (UB), Hôpital Haut-Lévêque [CHU Bordeaux], Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Modélisation et calculs pour l'électrophysiologie cardiaque (CARMEN), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-CHU Bordeaux [Bordeaux], and Potse, Mark

Subjects
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Abstract

International audience; Background: The mechanisms of ventricular fibrillation (VF) are classically distinguished in triggers versus substrate. However, their respective location in patients with structural heart disease (SHD) has not been investigated.Objective: To precisely locate trigger and substrate in patients presenting spontaneous VFMethods: Within a 5 year inclusion period, we investigated 14 patients (57±10 years) presenting a documented spontaneous episode of VF (lasting 16± 8s before cardioversion) associated with ischemic heart disease in 8, cardiomyopathy in 4 , and Brugada syndrome in 2. VF mapping was performed using multielectrode intracardiac and body-surface recordings. The VF trigger was located at the site of earliest ventricular activation. Reentrant drivers were identified during VF using phase mapping and confirmed by the demonstration of sequential circular activation of local electrograms. We performed endocardial and epicardial mapping during sinus rhythm. The abnormal substrate was identified as areas of low voltage (≤1mV) and fragmented electrograms (≥70ms).Results:The first beat of VF originated from Purkinje network in 8 and ventricular myocardium in 6; with the earliest endocardial electrogram preceding the QRS onset by 54 ±12ms . While myocardial triggers showed a single breakthrough on body surface mapping, Purkinje triggers were associated with simultaneous emergence of multiple breakthroughs. The transition from a focal trigger to a reentrant activity occurred at a median of 4 VF cycles [range: 2-7 cycles]. Mapping at the trigger sites showed low voltage fragmented electrograms during sinus rhythm in 12/14 patients.During VF, a driver region was consistently found to colocalize with the site of triggers in 12 patients, accounting for 34±10% of the total driver activities Catheter ablation was performed at these “trigger-driver” regions resulting in abolition of abnormal electrograms and arrhythmia-free outcome in 10 of 12 patients at 18±15 months follow up.Conclusion: Purkinje focal activity may show several ventricular exit sites. In most patients with SHD, the sites of VF triggers are intertwined with the maintaining substrate, providing a dual mechanistic target for interventional treatment.

Published
2018

120. Distinct Characteristics Of Human Ventricular Fibrillation In Its Initial Phase

Author

Haïssaguerre, Michel, Duchateau, Josselin, Cheniti, Ghassen, Puyo, Stéphane, Denis, Arnaud, Cochet, Hubert, Meo, Marianna, Kitamura, Takeshi, Takigawa, Masateru, Frontera, Antonio, Vlachos, Konstantinos George, Massoullié, Grégoire, Lam, Anna, Bourier, Felix, Pambrun, Thomas, Welte, Nicolas, Derval, Nicolas, Amraoui, Sana, Klotz, Nicolas, Sacher, Fréderic, Bordachar, Pierre, Ploux, Sylvain, Ritter, Philippe, Jaïs, Pierre, Vigmond, Edward J., Potse, Mark, Walton, Richard D., Dubois, Rémi, Bernus, Olivier, Hocini, Meleze, IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de cardiologie, CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], University Hospital of Ioannina, Hôpital de l'Ile, Université de Bordeaux (UB), Hôpital Haut-Lévêque [CHU Bordeaux], Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Modélisation et calculs pour l'électrophysiologie cardiaque (CARMEN), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-CHU Bordeaux [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)

Subjects
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Abstract

International audience; Background: Ventricular fibrillation (VF) progresses rapidly from an initial organized stage to chaotic fibrillation. The characteristics of initial drivers, that may be critical for therapeutic interventions, have not been investigated.Objective: To characterize the initial drivers of Human VFMethods: We evaluated 51 patients (44±10 years) who survived VF associated with ischemic heart disease in 15, cardiomyopathy in 14 and Brugada syndrome in 22. VF was mapped by intracardiac and body-surface recordings to analyze spatial organization, cycle lengths (CL), and drivers at the origin of wavefronts. We performed endocardial and epicardial mapping during sinus rhythm. The abnormal substrate was identified as areas of low voltage (≤1mV) and fragmented signals (≥70ms).Results: We mapped 69 episodes of spontaneous (n=12) or induced (n=57) VF for 17±10 s. The VF CL decreased from 208±28 to 172±25 ms (p

Published
2018

123. Incidence and outcomes of systemic infections in patients with leadless pacemakers: Data from the Micra IDE study

Author

El‐Chami, Mikhael F., primary, Soejima, Kyoko, additional, Piccini, Jonathan P., additional, Reynolds, Dwight, additional, Ritter, Philippe, additional, Okabe, Toshimasa, additional, Friedman, Paul A., additional, Cha, Yong‐Mei, additional, Stromberg, Kurt, additional, Holbrook, Reece, additional, Fagan, Dedra H., additional, and Roberts, Paul R., additional

Published
2019
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124. Long‐Term Follow‐Up of Idiopathic Ventricular Fibrillation in a Pediatric Population: Clinical Characteristics, Management, and Complications

Author

Frontera, Antonio, primary, Vlachos, Konstantinos, additional, Kitamura, Takeshi, additional, Mahida, Saagar, additional, Pillois, Xavier, additional, Fahy, Gerard, additional, Marquie, Christelle, additional, Cappato, Riccardo, additional, Stuart, Graham, additional, Defaye, Pascal, additional, Kaski, Juan Pablo, additional, Ector, Joris, additional, Maltret, Alice, additional, Scanu, Patrice, additional, Pasquie, Jean‐Luc, additional, Deisenhofer, Isabelle, additional, Blankoff, Ivan, additional, Scherr, Daniel, additional, Manninger, Martin, additional, Aizawa, Yoshifusa, additional, Koutbi, Linda, additional, Denis, Arnaud, additional, Pambrun, Thomas, additional, Ritter, Philippe, additional, Sacher, Frederic, additional, Hocini, Meleze, additional, Maury, Philippe, additional, Jaïs, Pierre, additional, Bordachar, Pierre, additional, Haïssaguerre, Michel, additional, and Derval, Nicolas, additional

Published
2019
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127. Role of medical reaction in management of inappropriate ventricular arrhythmia diagnosis: the inappropriate Therapy and HOme monitoRiNg (THORN) registry

Author

Perrin, Tilman, primary, Boveda, Serge, additional, Defaye, Pascal, additional, Rosier, Arnaud, additional, Sadoul, Nicolas, additional, Bordachar, Pierre, additional, Klug, Didier, additional, Ritter, Philippe, additional, Belhameche, Mohamed, additional, Babuty, Dominique, additional, Mansourati, Jacques, additional, Lazarus, Arnaud, additional, and Deharo, Jean-Claude, additional

Published
2019
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128. Membranous septal length and valve implantation depth of TAVR: Predictors of new permanent pacemaker implantation after TAVR

Author

Bonnet, G., primary, Pernot, M., additional, Zaouter, C., additional, Peltan, J., additional, Seguy, B., additional, Klotz, N., additional, Dijos, M., additional, Montaudon, M., additional, Ouattara, A., additional, Lafitte, Stéphane, additional, Ritter, Philippe, additional, Labrousse, L., additional, and Leroux, L., additional

Published
2019
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132. Localized Structural Alterations Underlying a Subset of Unexplained Sudden Cardiac Death

Author

Haïssaguerre, Michel, primary, Hocini, Mélèze, additional, Cheniti, Ghassen, additional, Duchateau, Josselin, additional, Sacher, Frédéric, additional, Puyo, Stéphane, additional, Cochet, Hubert, additional, Takigawa, Masateru, additional, Denis, Arnaud, additional, Martin, Ruairidh, additional, Derval, Nicolas, additional, Bordachar, Pierre, additional, Ritter, Philippe, additional, Ploux, Sylvain, additional, Pambrun, Thomas, additional, Klotz, Nicolas, additional, Massoullié, Gregoire, additional, Pillois, Xavier, additional, Dallet, Corentin, additional, Schott, Jean-Jacques, additional, Scouarnec, Solena, additional, Ackerman, Michael J., additional, Tester, David, additional, Piot, Olivier, additional, Pasquié, Jean-Luc, additional, Leclerc, Christophe, additional, Hermida, Jean-Sylvain, additional, Gandjbakhch, Estelle, additional, Maury, Philippe, additional, Labrousse, Louis, additional, Coronel, Ruben, additional, Jais, Pierre, additional, Benoist, David, additional, Vigmond, Edward, additional, Potse, Mark, additional, Walton, Richard, additional, Nademanee, Koonlawee, additional, Bernus, Olivier, additional, and Dubois, Remi, additional

Published
2018
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137. Defibrillation testing is mandatory in patients with subcutaneous implantable cardioverter-defibrillator to confirm appropriate ventricular fibrillation detection.

Author

UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, Le Polain De Waroux, Jean-Benoît, Ploux, Sylvain, Mondoly, Pierre, Eschalier, Romain, Strik, Marc, Houard, Laura, Pierre, Bertrand, Buliard, Samuel, Klotz, Nicolas, Ritter, Philippe, Haissaguerre, Michel, Mahfouz, Karim, Bordachar, Pierre, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, Le Polain De Waroux, Jean-Benoît, Ploux, Sylvain, Mondoly, Pierre, Eschalier, Romain, Strik, Marc, Houard, Laura, Pierre, Bertrand, Buliard, Samuel, Klotz, Nicolas, Ritter, Philippe, Haissaguerre, Michel, Mahfouz, Karim, and Bordachar, Pierre

Abstract

BACKGROUND: The subcutaneous implantable cardioverter-defibrillator (S-ICD) remains a new technology requiring accurate assessment of the various aspects of its functioning. Isolated cases of delayed sensing of ventricular arrhythmia have been described. OBJECTIVE: The purpose of this multicenter study was to assess the quality of sensing during induced ventricular fibrillation (VF). METHODS: One hundred thirty-seven patients underwent induction of VF at the end of the S-ICD implantation. RESULTS: VF induction was successful in 133 patients (97%). Mean time to first therapy was 16.2 ± 3.1 seconds, with a substantial range from 12.5 to 27.0 seconds. Four different detection profiles were arbitrarily defined: (1) optimal detection (n = 39 [29%]); (2) undersensing with moderate prolongation of time to therapy (<18 seconds; n = 68 [51%]); (3) undersensing with significant prolongation of the time to therapy (>18 seconds; n = 19 [14%]); and (4) absence of therapy or prolonged time to therapy related to noise oversensing (n = 7 [6%]). In some of the patients in the last group, despite induction of VF the initial counter was never filled, the device did not charge the capacitors, and the shock was not delivered because of a sustained diagnosis of noise (n = 5). A manual shock by the device or an external shock had to be delivered to restore the sinus rhythm. CONCLUSION: Our study demonstrated a marked sensing delay leading to prolonged time to therapy in a large number of S-ICD patients. A few worrisome cases of noise oversensing inhibiting the therapies were detected. These results support the need for systematic intraoperative defibrillation testing.

Published
2018

138. Electrical Substrates Driving Response to Cardiac Resynchronization Therapy: A Combined Clinical–Computational Evaluation

Author

Huntjens, Peter R., Huntjens, Peter R., Ploux, Sylvain, Strik, Marc, Walmsley, John, Ritter, Philippe, Haissaguerre, Michel, Prinzen, Frits W., Delhaas, Tammo, Lumens, Joost, Bordachar, Pierre, Huntjens, Peter R., Huntjens, Peter R., Ploux, Sylvain, Strik, Marc, Walmsley, John, Ritter, Philippe, Haissaguerre, Michel, Prinzen, Frits W., Delhaas, Tammo, Lumens, Joost, and Bordachar, Pierre

Abstract

BACKGROUND: The predictive value of interventricular versus intraventricular dyssynchrony for response to cardiac resynchronization therapy (CRT) remains unclear. We investigated the relative importance of both ventricular electrical substrate components for left ventricular (LV) hemodynamic function. METHODS AND RESULTS: First, we used the cardiovascular computational model CircAdapt to characterize the isolated effect of intrinsic interventricular and intraventricular activation on CRT response (Delta LVdP/dt(max)). Simulated Delta LVdP/dt(max) (range: 1.3%-26.5%) increased considerably with increasing interventricular dyssynchrony. In contrast, the isolated effect of intraventricular dyssynchrony in either the LV or right ventricle was limited (Delta LVdP/dt(max) range: 12.3%-18.3% and 14.1%-15.7%, respectively). Effects of activation during biventricular pacing on Delta LVdP/dt(max) were small. Second, electrocardiographic imaging-derived activation characteristics of 51 CRT candidates were used to personalize ventricular activation in CircAdapt. The individualized models were subsequently used to assess the accuracy of Delta LVdP/dt(max) prediction based on the electrical data. The model-predicted Delta LVdP/dt(max) was close to the actual value in patients with left bundle branch block (measured-simulated: 2.7 +/- 9.0%) when only intrinsic interventricular dyssynchrony was personalized. Among patients without left bundle branch block, Delta LVdP/dt(max) was systematically overpredicted by CircAdapt (measured-simulated: 9.2 +/- 7.1%). Adding intraventricular activation to the model did not improve the accuracy of the response prediction. CONCLUSIONS: Computer simulations revealed that intrinsic interventricular dyssynchrony is the dominant component of the electrical substrate driving the response to CRT. Intrinsic intraventricular dyssynchrony and any dyssynchrony during biventricular pacing play a minor role in this respect. This may facilitate patient-specif

Published
2018

139. Updated performance of the Micra transcatheter pacemaker in the real-world setting:A comparison to the investigational study and a transvenous historical control

Author

El-Chami, Mikhael F., Al-Samadi, Faisal, Clementy, Nicolas, Garweg, Christophe, Martinez-Sande, Jose Luis, Piccini, Jonathan P., Iacopino, Saverio, Lloyd, Michael, Viñolas Prat, Xavier, Jacobsen, Michael Dilou, Ritter, Philippe, Johansen, Jens Brock, Tondo, Claudio, Liu, Fang, Fagan, Dedra H., Eakley, Alyssa K., Roberts, Paul R., El-Chami, Mikhael F., Al-Samadi, Faisal, Clementy, Nicolas, Garweg, Christophe, Martinez-Sande, Jose Luis, Piccini, Jonathan P., Iacopino, Saverio, Lloyd, Michael, Viñolas Prat, Xavier, Jacobsen, Michael Dilou, Ritter, Philippe, Johansen, Jens Brock, Tondo, Claudio, Liu, Fang, Fagan, Dedra H., Eakley, Alyssa K., and Roberts, Paul R.

Abstract

Background: Early results of the Micra Investigational Device Exemption (IDE) study and Micra Post-Approval Registry (PAR) demonstrated excellent safety and efficacy performance; however, intermediate-term results across a large patient population in the real-world setting have not been evaluated. Objectives: We report updated performance of the Micra transcatheter pacemaker from a worldwide PAR and compare it with the IDE study as well as a transvenous historical control. Methods: The safety objective of the analysis was system- or procedure-related major complications through 12 months postimplantation. We compared the major complication rate with that of the 726 patients from the IDE and with a reference data set of 2667 patients with transvenous pacemakers by using a Fine-Gray competing risk model. Results: The Micra device was successfully implanted in 1801 of 1817 patients (99.1%). The mean follow-up period was 6.8 ± 6.9 months. Through 12 months, the major complication rate was 2.7% (95% confidence interval [CI] 2.0%–3.7%). The risk of major complications for Micra PAR patients was 63% lower than that for patients with transvenous pacemakers through 12 months postimplantation (hazard ratio 0.37; 95% CI 0.27–0.52; P <.001). The major complication rate trended lower in the PAR than in the IDE study (hazard ratio 0.71; 95% CI 0.44–1.1; P =.160), driven by the lower pericardial effusion rate in the PAR. There were 3 cases of infection associated with the procedure, but none required device removal and there were no battery or telemetry issues. Pacing thresholds were low and stable through 12 months postimplantation. Conclusion: Performance of the Micra transcatheter pacemaker in international clinical practice remains consistent with previously reported data. Major complications were infrequent and occurred 63% less often compared to transvenous systems. Clinical Trial Registration: Micra Transcatheter Pacing System Post-Approval Registry ClinicalTrials.gov

Published
2018

140. Contractility sensor-guided optimization of cardiac resynchronization therapy: results from the RESPOND-CRT trial

Author

Brugada, Josep, Delnoy, Peter Paul, Brachmann, Johannes, Reynolds, Dwight, Padeletti, Luigi, Noelker, Georg, Kantipudi, Charan, Rubin Lopez, José Manuel, Dichtl, Wolfgang, Borri-Brunetto, Alberto, Verhees, Luc, Ritter, Philippe, Singh, Jagmeet P, Mansourati, Jacques, Cardiology Department, Thorax Clinic Institute, Hospital Cliınic, Institut d'Investigacions Biomèdiques [Barcelona], Universitat de Barcelona (UB), Isala Klinieken, Coburg Hospital, University of Oklahoma (OU), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), IRCCS Multimedica, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Herz- und Diabeteszentrum, Piedmont Heart Institute (PHI - ATLANTA), PIEDMONT HEART INSTITUTE, Hospital Universitario Central de Asturias, Department of Internal Medicine III (Dep Med Int - INNSBRUCK), Innsbruck Medical University [Austria] (IMU), LivaNova Cardiac Rythm Management (LivaNova CRM - SALUGGIA), LivaNova France SAS, CHRU Bordeaux, Massachusetts General Hospital, Harvard Medical School [Boston] (HMS), Optimisation des régulations physiologiques (ORPHY (EA 4324)), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Département Cardiologie, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre d'Investigation Clinique (CIC - Brest), and Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, medicine.medical_specialty, New York Heart Association Class, medicine.medical_treatment, Cardiac resynchronization therapy, RESPOND, 030204 cardiovascular system & hematology, Contractility, Cardiac Resynchronization Therapy, SonR, 03 medical and health sciences, QRS complex, 0302 clinical medicine, Double-Blind Method, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine, Humans, 030212 general & internal medicine, Cardiac Resynchronization Therapy Devices, Prospective Studies, CRT optimization, Lead (electronics), Aged, Atrium (architecture), business.industry, Hazard ratio, Stroke Volume, Equipment Design, medicine.disease, Myocardial Contraction, HF hospitalization, AV and VV optimization, Treatment Outcome, Cardiac contractility, Heart failure, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Adaptive CRT, Follow-Up Studies, Heart Failure, Systolic
Abstract

Aims Although cardiac resynchronization therapy (CRT) is effective in patients with systolic heart failure (HF) and a wide QRS interval, a substantial proportion of patients remain non-responsive. The SonR contractility sensor embedded in the right atrial lead enables individualized automatic optimization of the atrioventricular (AV) and interventricular (VV) timings. The RESPOND-CRT study investigated the safety and efficacy of the contractility sensor system in HF patients undergoing CRT. Methods and results RESPOND-CRT was a prospective, randomized, double-blinded, multicentre, non-inferiority trial. Patients were randomized (2:1, respectively) to receive weekly, automatic CRT optimization with SonR vs. an Echo-guided optimization of AV and VV timings. The primary efficacy endpoint was the rate of clinical responders (patients alive, without adjudicated HF-related events, with improvement in New York Heart Association class or quality of life), at 12 months. The study randomized 998 patients. The rate of responders was 75.0% in the SonR group vs. 70.4% within the Echo group (mean difference, 4.6%; 95% CI, 1.4% to 10.6%; P

Published
2017
Full Text
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141. International Society for Therapeutic Ultrasound Conference 2016

Author

Fowlkes, Brian, Ghanouni, Pejman, Sanghvi, Narendra, Coussios, Constantin, Lyon, Paul C., Gray, Michael, Mannaris, Christophoros, Victor, Marie de Saint, Stride, Eleanor, Cleveland, Robin, Carlisle, Robert, Wu, Feng, Middleton, Mark, Gleeson, Fergus, Aubry, Jean-Franҫois, Pauly, Kim Butts, Moonen, Chrit, Vortman, Jacob, Sharabi, Shirley, Daniels, Dianne, Last, David, Guez, David, Levy, Yoav, Volovick, Alexander, Grinfeld, Javier, Rachmilevich, Itay, Amar, Talia, Zibly, Zion, Mardor, Yael, Harnof, Sagi, Plaksin, Michael, Weissler, Yoni, Shoham, Shy, Kimmel, Eitan, Naor, Omer, Farah, Nairouz, Paeng, Dong-Guk, Xu, Zhiyuan, Snell, John, Quigg, Anders H., Eames, Matthew, Jin, Changzhu, Everstine, Ashli C., Sheehan, Jason P., Lopes, Beatriz S., Kassell, Neal, Looi, Thomas, Khokhlova, Vera, Mougenot, Charles, Hynynen, Kullervo, Drake, James, Slayton, Michael, Amodei, Richard C., Compton, Keegan, McNelly, Ashley, Latt, Daniel, Kearney, John, Melodelima, David, Dupre, Aurelien, Chen, Yao, Perol, David, Vincenot, Jeremy, Chapelon, Jean-Yves, Rivoire, Michel, Guo, Wei, Ren, Guoxin, Shen, Guofeng, Neidrauer, Michael, Zubkov, Leonid, Weingarten, Michael S., Margolis, David J., Lewin, Peter A., McDannold, Nathan, Sutton, Jonathan, Vykhodtseva, Natalia, Livingstone, Margaret, Kobus, Thiele, Zhang, Yong-Zhi, Schwartz, Michael, Huang, Yuexi, Lipsman, Nir, Jain, Jennifer, Chapman, Martin, Sankar, Tejas, Lozano, Andres, Yeung, Robert, Damianou, Christakis, Papadopoulos, Nikolaos, Brokman, Omer, Zadicario, Eyal, Brenner, Ori, Castel, David, Wu, Shih-Ying, Grondin, Julien, Zheng, Wenlan, Heidmann, Marc, Karakatsani, Maria Eleni, Sánchez, Carlos J. Sierra, Ferrera, Vincent, Konofagou, Elisa E., Yiannakou, Marinos, Cho, HongSeok, Lee, Hwayoun, Han, Mun, Choi, Jong-Ryul, Lee, Taekwan, Ahn, Sanghyun, Chang, Yongmin, Park, Juyoung, Ellens, Nicholas, Partanen, Ari, Farahani, Keyvan, Airan, Raag, Carpentier, Alexandre, Canney, Michael, Vignot, Alexandre, Lafon, Cyril, Delattre, Jean-yves, Idbaih, Ahmed, Odéen, Henrik, Bolster, Bradley, Jeong, Eun Kee, Parker, Dennis L., Gaur, Pooja, Feng, Xue, Fielden, Samuel, Meyer, Craig, Werner, Beat, Grissom, William, Marx, Michael, Weber, Hans, Taviani, Valentina, Hargreaves, Brian, Tanaka, Jun, Kikuchi, Kentaro, Ishijima, Ayumu, Azuma, Takashi, Minamihata, Kosuke, Yamaguchi, Satoshi, Nagamune, Teruyuki, Sakuma, Ichiro, Takagi, Shu, Santin, Mathieu D., Marsac, Laurent, Maimbourg, Guillaume, Monfort, Morgane, Larrat, Benoit, François, Chantal, Lehéricy, Stéphane, Tanter, Mickael, Samiotaki, Gesthimani, Wang, Shutao, Acosta, Camilo, Feinberg, Eliza R., Kovacs, Zsofia I., Tu, Tsang-Wei, Papadakis, Georgios Z., Reid, William C., Hammoud, Dima A., Frank, Joseph A., Kovacs, Zsofia i., Kim, Saejeong, Jikaria, Neekita, Bresler, Michele, Qureshi, Farhan, Xia, Jingjing, Tsui, Po-Shiang, Liu, Hao-Li, Plata, Juan C., Sveinsson, Bragi, Salgaonkar, Vasant A., Adams, Matthew, Diederich, Chris, Ozhinsky, Eugene, Bucknor, Matthew D., Rieke, Viola, Mikhail, Andrew, Severance, Lauren, Negussie, Ayele H., Wood, Bradford, de Greef, Martijn, Schubert, Gerald, Ries, Mario, Poorman, Megan E., Dockery, Mary, Chaplin, Vandiver, Dudzinski, Stephanie O., Spears, Ryan, Caskey, Charles, Giorgio, Todd, Costa, Marcia M., Papaevangelou, Efthymia, Shah, Anant, Rivens, Ian, Box, Carol, Bamber, Jeff, ter Haar, Gail, Burks, Scott R., Nagle, Matthew, Nguyen, Ben, Milo, Blerta, Le, Nhan M., Song, Shaozhen, Zhou, Kanheng, Nabi, Ghulam, Huang, Zhihong, Ben-Ezra, Shmuel, Rosen, Shani, Mihcin, Senay, Strehlow, Jan, Karakitsios, Ioannis, Le, Nhan, Schwenke, Michael, Demedts, Daniel, Prentice, Paul, Haase, Sabrina, Preusser, Tobias, Melzer, Andreas, Mestas, Jean-Louis, Chettab, Kamel, Gomez, Gustavo Stadthagen, Dumontet, Charles, Werle, Bettina, Marquet, Fabrice, Bour, Pierre, Vaillant, Fanny, Amraoui, Sana, Dubois, Rémi, Ritter, Philippe, Haïssaguerre, Michel, Hocini, Mélèze, Bernus, Olivier, Quesson, Bruno, Livneh, Amit, Adam, Dan, Robin, Justine, Arnal, Bastien, Fink, Mathias, Pernot, Mathieu, Khokhlova, Tatiana D., Schade, George R., Wang, Yak-Nam, Kreider, Wayne, Simon, Julianna, Starr, Frank, Karzova, Maria, Maxwell, Adam, Bailey, Michael R., Lundt, Jonathan E., Allen, Steven P., Sukovich, Jonathan R., Hall, Timothy, Xu, Zhen, May, Philip, Lin, Daniel W., Constans, Charlotte, Deffieux, Thomas, Aubry, Jean-Francois, Park, Eun-Joo, Ahn, Yun Deok, Kang, Soo Yeon, Park, Dong-Hyuk, Lee, Jae Young, Vidal-Jove, J., Perich, E., Ruiz, A., Jaen, A., Eres, N., del Castillo, M. Alvarez, Myers, Rachel, Kwan, James, Coviello, Christian, Rowe, Cliff, Crake, Calum, Finn, Sean, Jackson, Edward, Pouliopoulos, Antonios, Li, Caiqin, Tinguely, Marc, Tang, Meng-Xing, Garbin, Valeria, Choi, James J., Folkes, Lisa, Stratford, Michael, Nwokeoha, Sandra, Li, Tong, Farr, Navid, D’Andrea, Samantha, Gravelle, Kayla, Chen, Hong, Lee, Donghoon, Hwang, Joo Ha, Tardoski, Sophie, Ngo, Jacqueline, Gineyts, Evelyne, Roux, Jean-Pau, Clézardin, Philippe, Conti, Allegra, Magnin, Rémi, Gerstenmayer, Matthieu, Lux, François, Tillement, Olivier, Mériaux, Sébastien, Penna, Stefania Della, Romani, Gian Luca, Dumont, Erik, Sun, Tao, Power, Chanikarn, Miller, Eric, Sapozhnikov, Oleg, Tsysar, Sergey, Yuldashev, Petr V., Svet, Victor, Li, Dongli, Pellegrino, Antonio, Petrinic, Nik, Siviour, Clive, Jerusalem, Antoine, Yuldashev, Peter V., Cunitz, Bryan W., Dunmire, Barbrina, Inserra, Claude, Guedra, Matthieu, Mauger, Cyril, Gilles, Bruno, Solovchuk, Maxim, Sheu, Tony W. H., Thiriet, Marc, Zhou, Yufeng, Neufeld, Esra, Baumgartner, Christian, Payne, Davnah, Kyriakou, Adamos, Kuster, Niels, Xiao, Xu, McLeod, Helen, Dillon, Christopher, Payne, Allison, Khokhova, Vera A., Sinilshchikov, Ilya, Andriyakhina, Yulia, Rybyanets, Andrey, Shvetsova, Natalia, Berkovich, Alex, Shvetsov, Igor, Shaw, Caroline J., Civale, John, Giussani, Dino, Lees, Christoph, Ozenne, Valery, Toupin, Solenn, Salgaonkar, Vasant, Kaye, Elena, Monette, Sebastien, Maybody, Majid, Srimathveeravalli, Govindarajan, Solomon, Stephen, Gulati, Amitabh, Bezzi, Mario, Jenne, Jürgen W., Lango, Thomas, Müller, Michael, Sat, Giora, Tanner, Christine, Zangos, Stephan, Günther, Matthias, Dinh, Au Hoang, Niaf, Emilie, Bratan, Flavie, Guillen, Nicolas, Souchon, Rémi, Lartizien, Carole, Crouzet, Sebastien, Rouviere, Olivier, Han, Yang, Payen, Thomas, Palermo, Carmine, Sastra, Steve, Olive, Kenneth, van Breugel, Johanna M., van den Bosch, Maurice A., Fellah, Benjamin, Le Bihan, Denis, Hernandez-Garcia, Luis, Cain, Charles A., Lyka, Erasmia, Elbes, Delphine, Li, Chunhui, Tamano, Satoshi, Jimbo, Hayato, Yoshizawa, Shin, Fujiwara, Keisuke, Itani, Kazunori, Umemura, Shin-ichiro, Stoianovici, Dan, Zaini, Zulfadhli, Takagi, Ryo, Zong, Shenyan, Watkins, Ron, Pascal-Tenorio, Aurea, Jones, Peter, Butts-Pauly, Kim, Bouley, Donna, Chen, Yazhu, Lin, Chung-Yin, Hsieh, Han-Yi, Wei, Kuo-Chen, Garnier, Camille, Renault, Gilles, Seifabadi, Reza, Wilson, Emmanuel, Eranki, Avinash, Kim, Peter, Lübke, Dennis, Huber, Peter, Georgii, Joachim, Dresky, Caroline V., Haller, Julian, Yarmolenko, Pavel, Sharma, Karun, Celik, Haydar, Li, Guofeng, Qiu, Weibao, Zheng, Hairong, Tsai, Meng-Yen, Chu, Po-Chun, Webb, Taylor, Vyas, Urvi, Walker, Matthew, Zhong, Jidan, Waspe, Adam C., Hodaie, Mojgan, Yang, Feng-Yi, Huang, Sin-Luo, Zur, Yuval, Assif, Benny, Aurup, Christian, Kamimura, Hermes, Carneiro, Antonio A., Rothlübbers, Sven, Schwaab, Julia, Houston, Graeme, Azhari, Haim, Weiss, Noam, Sosna, Jacob, Goldberg, S. Nahum, Barrere, Victor, Jang, Kee W., Lewis, Bobbi, Wang, Xiaotong, Suomi, Visa, Edwards, David, Larrabee, Zahary, Hananel, Arik, Rafaely, Boaz, Debbiny, Rasha Elaimy, Dekel, Carmel Zeltser, Assa, Michael, Menikou, George, Mouratidis, Petros, Pineda-Pardo, José A., de Pedro, Marta Del Álamo, Martinez, Raul, Hernandez, Frida, Casas, Silvia, Oliver, Carlos, Pastor, Patricia, Vela, Lidia, Obeso, Jose, Greillier, Paul, Zorgani, Ali, Catheline, Stefan, Solovov, Vyacheslav, Vozdvizhenskiy, Michael O., Orlov, Andrew E., Wu, Chueh-Hung, Sun, Ming-Kuan, Shih, Tiffany T., Chen, Wen-Shiang, Prieur, Fabrice, Pillon, Arnaud, Cartron, Valerie, Cebe, Patrick, Chansard, Nathalie, Lafond, Maxime, Seya, Pauline Muleki, Bera, Jean-Christophe, Boissenot, Tanguy, Fattal, Elias, Bordat, Alexandre, Chacun, Helene, Guetin, Claire, Tsapis, Nicolas, Maruyama, Kazuo, Unga, Johan, Suzuki, Ryo, Fant, Cécile, Rogez, Bernadette, Afadzi, Mercy, Myhre, Ola Finneng, Vea, Siri, Bjørkøy, Astrid, Yemane, Petros Tesfamichael, van Wamel, Annemieke, Berg, Sigrid, Hansen, Rune, Angelsen, Bjørn, and Davies, Catharina

Subjects
Meeting Abstracts
Published
2017

142. 5th International Symposium on Focused Ultrasound

Author

Abounader, Roger, Abraham, Christopher, Adema, Gosse, Agrawal, Punit, Airan, Raag, Aleman, Dionne, Alexander, Phillip, Alkins, Ryan, Alnazeer, Moez, Altman, Michael, Aly, Amirah, Amaral, Joao G., Amrahli, Maral, Amraoui, Sana, Andarawewa, Kumari, Andriyakhina, Yulia, Angstadt, Mary, Ankou, Bénédicte, Arias, Ana C., Arvanitis, Costas, Asadnia, Kiana, Aubert, Isabelle, Aubry, Jean-Francois, Aurup, Christian, Bader, Kenneth, Badr, Lena, Baek, Hongchae, Barbato, Gaetano, Beccaria, Kevin, Bellorofonte, Carlo, Benson, Lee, Bernus, Olivier, Berriet, Rémi, Bertolina, Jim, Beskin, Viktoriya, Bessière, Francis, Bethune, Allison, Bezzi, Mario, Bond, Aaron, Bonomo, Guido, Borowsky, Alexander, Borys, Nicolas, Böttcher, Joachim, Bouley, Donna, Bour, Pierre, Bourekas, Eric, Brenin, David, Brokman, Omer, Brosh, Inbar, Buckner, Andrew, Bullock, Timothy, Cafarelli, Andrea, Cahill, Jessica, Camarena, Francisco, Camelo-Piragua, Sandra, Campbell, Benjamin, Campbell, Fiona, Cannata, Jon, Canney, Michael, Carlson, Roy, Carneiro, Antonio, Carpentier, Alexandre, Catheline, Stefan, Cavin, Ian, Cesana, Claudio, Chabok, Hamid R., Chamanara, Marzieh, Chang, Jin H., Chang, Won S., Changizi, Barbara, Chapelon, Jean Y., Chaplin, Vandiver, Chapman, Martin, Chaudhary, Neeraj, Chaussy, Christian, Chen, Cherry, Chen, Johnny, Chen, Wohsing, Chen, Xiaoming, Chevalier, Philippe, Chiou, George, Chisholm, Alexander, Christofferson, Ivy, Chung, Hyun H., Ciuti, Gastone, Clement, Gregory, Cooper, Mark, Corea, Joseph, Corso, Cristiano, Cosman, Josh, Coughlin, Dezba, Crake, Calum, Cunitz, Bryan, Curiel, Laura, Curley, Colleen T., Czarnota, Gregory, Dababou, Susan, Dallapiazza, Robert, de Bever, Joshua, de Jager, Bram, de Ruiter, Joost, de Senneville, Baudouin D., Deckers, Roel, Delattre, Jean-Yves, den Brok, Martijn, Dhanaliwala, Ali, Diodato, Alessandro, Dixon, Adam, Donner, Elizabeth, Downs, Matthew, Du, Zhongmin, Dubois, Rémi, Dupre, Aurelien, Eikelenboom, Dylan, Elias, W. J., Ellens, Nicholas, Endre, Ruby, Eran, Ayelet, Erasmus, Hans-Peter, Everstine, Ashli, Farahani, Keyvan, Farrer, Alexis, Farry, Justin, Federau, Christian, Feng, Xue, Ferrer, Cyril, Ferrera, Vincent, Fishman, Paul, Foley, Jessica, Frenkel, Victor, Fütterer, Jurgen, Gach, H. M., Gandhi, Dheeraj, Gertner, Michael, Goldsher, Dorit, Gorgone, Alessandro, Greillier, Paul, Griesenauer, Rebekah, Grissom, William, Grondin, Julien, Guha, Chandan, Gulati, Amitabh, Gullapalli, Rao, Guo, Sijia, Gupta, Samit, Gurm, Hitinder, Gwinn, Ryder, Hadley, Rock, Haïssaguerre, Michel, Hammoud, Dima, Hananel, Arik, Hargrove, Amelia, Hatch, Robert, Haworth, Kevin, Hazan, Eilon, He, Ye, Heemels, Maurice, Heerschap, Arend, Hilas, Elaine, Hoang-Xuan, Khe, Hocini, Mélèze, Hodaie, Mojgan, Hofmann, Denis, Holland, Christy, Hoogenboom, Martijn, Hopyan, Sevan, Hossack, John, Houdouin, Alexandre, Hsu, Po-Hung, Hu, Jim, Hurwitz, Mark, Huss, Diane, Hwang, Chang-il, Hwang, Joo H., Idbaih, Ahmed, Ikeuchi, Masahiko, Ingham, Elizabeth, Ives, Kimberly, Izumi, Masashi, Jackson-Lewis, Vernice, Janát-Amsbury, Margit, Jang, Kee W., Jedruszczuk, Kathleen, Jiménez-Gambín, Sergio, Jiménez, Noé, Johnson, Sara, Jonathan, Sumeeth, Joy, Joyce, Jung, Hyun H., Jung, Na Y., Kahn, Itamar, Kamimura, Hermes, Kamrava, Seyed K., Kang, Jeeun, Kang, Kook J., Kang, Soo Y., Kao, Yi-tzu, Katti, Prateek, Kawasaki, Motohiro, Kaye, Elena, Keupp, Jochen, Kim, AeRang, Kim, Harry, Kim, Hyun-Chul, Kim, Hyuncheol, Kim, Hyungmin, Kim, Min S., Kim, Namho, Kiyasu, Katsuhito, Kneepkens, Esther, Knopp, Michael, Kobus, Thiele, Koral, Korgun, Kreider, Wayne, Krishna, Vibhor, Krug, Roland, Krupa, Steve, Kuo, Chia-Chun, Kwiecinski, Wojciech, Lacoste, Romain, Lam, Heather, Lamberti-Pasculli, Maria, Lang, Brian, Larner, James, Larrabee, Zachary, Leach, J. K., LeBlang, Suzanne, Leclercq, Delphine, Lee, Hak J., Lee, Jong-Hwan, Lehericy, Stéphane, Leighton, Wan, Leung, Steven, Lewis, Bobbi, Lewis, Matthew, Li, Dawei, Linn, Sabine, Lipsman, Nir, Liu, Hao-Li, Liu, Jingfei, Lopes, M. B., Lotz, Jeff, Lu, Xin, Lundt, Jonathan, Luo, Xi, Lustgarten, Lior, Lustig, Micheal, Macoskey, Jonathan, Madore, Bruno, Maev, Roman, Magat, Julie, Maimbourg, Guillaume, Maimon, Noam, Mainprize, Todd, Malayer, Jerry, Maples, Danny, Marquet, Fabrice, Marrocchio, Cristina, Marx, Mike, Mastorakos, Panagiotis, Mauri, Giovanni, McLean, Hailey, McMichael, John, Mead, Brian P., Melodelima, David, Melot-Dusseau, Sandrine, Menciassi, Arianna, Merrill, Robb, Meyer, Joshua, Midiri, Massimo, Miga, Michael, Migliore, Ilaria G., Miller, Eric, Minalga, Emilee, Moon, Hyungwon, Moore, David, Mourad, Pierre, Mouratidis, Petros, Mueller, Michael, Mugler, John, Muller, Sébastien, Namba, Hirofumi, Naor, Omer, Nassar, Maria, Nazai, Navid, Negron, Karina, Negussie, Ayele, Nguyen, Thai-Son, Nicolay, Klaas, Nikolaeva, Anastasia V., Oetgen, Matthew, Olive, Kenneth, Olumolade, Oluyemi, Orsi, Franco, Owens, Gabe, Ozilgen, Arda, Padegimas, Linas, Palermo, Carmine, Pan, Chia-Hsin, Pandey, Aditya, Papadakis, Georgios, Park, Chang K., Park, Sang M., Parker, Jonathon, Parvizi, Mohammad H., Pascal-Tenorio, Aurea, Patel, Janish, Patz, Sam, Payen, Thomas, Perich, Eloi, Pernot, Mathieu, Perol, David, Perry, James, Pillarisetty, Venu, Pioche, Mathieu, Pizzuto, Matthew, Plaksin, Michael, Plata, Juan, Price, Karl, Prince, Jessica, Przedborski, Serge, Quinones-Hinojosa, Alfredo, Ramachandran, Akhilesh, Ranjan, Ashish, Ravikumar, Vinod, Reichenbach, Juergen, Repasky, Elizabeth, Rezai, Ali, Ritter, Philippe, Rivoire, Michel, Rochman, Carrie, Rosenberg, Jarrett, Rosnitskiy, Pavel B., Ruiz, Antonio, Sahgal, Arjun, Samiotaki, Gesthimani, Sanghvi, Narendra, Santin, Mathieu D., Santos, Domiciano, Sasaki, Noboru, Sastra, Steve, Schade, George, Schall, Jeffrey, Schlesinger, Ilana, Schmitt, Paul, Schwaab, Julia, Scionti, Stephen, Scipione, Roberto, Scoarughi, Gian L., Scott, Serena, Sebeke, Lukas, Seifabadi, Reza, Seo, Jai, Sesenoglu-Laird, Ozge, Shah, Binit, Shahriari, Kian, Shaikh, Sumbul, Shea, Jill, Shi, Jiaqi, Shim, Jenny, Shinkov, Alexander, Shuman, Jillian, Silvestrini, Matthew, Sim, Changbeom, Sin, Vivian, Sinai, Alon, Singh, Manoj, Sinilshchikov, Ilya, Skalina, Karin, Slingluff, Craig, So, Po-Wah, Solomon, Stephen, Son, Keon H., Sperling, Scott, Stein, Ruben, Stein, Sherman, Stevens, Aaron, Stimec, Jennifer, Storm, Gert, Straube, William, Suelmann, Britt, Sutton, Jonathan, Svedin, Bryant, Takemasa, Ryuichi, Takiguchi, Mitsuyoshi, Tam, Emily, Tan, Jeremy, Tang, Xinyan, Tanter, Mickael, Tebebi, Pamela, Tehrani, Seruz, Temple, Michael, Teofilovic, Dejan, ter Haar, Gail, Terzi, Marina E., Thueroff, Stefan, Timbie, Kelsie, Tognarelli, Selene, Tretbar, Steffen, Trudeau, Maureen, Tsai, Yi-Chieh, Tsysar, Sergey A., Tucci, Samantha, Tuveson, David, Ushida, Takahiro, Vaessen, Paul, Vaillant, Fanny, Van Arsdell, Glen, van Breugel, Johanna, Van der Jeugd, Anneke, Van der Wall, Elsken, van Diest, Paul, van Stralen, Marijn, Varano, Gianluca, Velat, Manuela, Vidal-Jove, Joan, Vigna, Paolo D., Vignot, Alexandre, Vincenot, Jeremy, Vykhodtseva, Natalia, Wang, Bin, Wang, Han, Wang, Kevin, Wang, Qi, Wang, Qingguo, Wang, Shengping, Wang, Yak-Nam, Wang, Zhaorui, Wardlow, Rachel, Warren, Amy, Waszczak, Barbara, Watson, Katherine, Webb, Taylor, Wei-Bin, Shen, Wei, Kuo-Chen, Weiss, Steffen, Weissler, Yoni, Werner, Beat, Wesseling, Pieter, Williams, Noelle, Wilson, Emmanuel, Wintermark, Max, Witkamp, Arjen, Wong, Carlos, Wu, Jing-Fu, Wydra, Adrian, Xu, Alexis, Xu, Doudou, Xu, Su, Yang, Georgiana, Yang, Nai-Yi, Yao, Chen, Yarowsky, Paul, Ye, Patrick P., Yuldashev, Petr, Zaaroor, Menashe, Zachiu, Cornel, Zahos, Peter, Zangos, Stephan, Zhang, Dandan, Zhang, Hua, Zhang, Jimin, Zhang, Junhai, Zhang, Xi, Zhao, Li, Zhong, Pei, Zhuo, Jiachen, Zidowitz, Stephan, Zinke, Wolf, Zorgani, Ali, and Aerospace and Ocean Engineering

Subjects
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Published version

Published
2016

143. PATIENT SELECTION FOR DE-NOVO LEADLESS SINGLE-CHAMBER VENTRICULAR PACING: RESULTS FROM THE MICRA TRANSCATHETER PACING STUDY

Author

Piccini, Jonathan P., primary, Stromberg, Kurt, additional, Jackson, Kevin, additional, Kowal, Robert, additional, Duray, Gabor, additional, El-Chami, Mikhael, additional, Crossley, George, additional, Hummel, John, additional, Narasimhan, Calambur, additional, Razali, Omar, additional, Ritter, Philippe, additional, Roberts, Paul, additional, Soejima, Kyoko, additional, Reynolds, Dwight, additional, and Chinitz, Larry, additional

Published
2018
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144. Characterization of hypertrophic cardiomyopathy according to global, regional, and multi-layer longitudinal strain analysis, and prediction of sudden cardiac death

Author

Vergé, Marie-Philippe, primary, Cochet, Hubert, additional, Reynaud, Amélie, additional, Morlon, Lucas, additional, Peyrou, Jérôme, additional, Vincent, Cécile, additional, Rooryck, Caroline, additional, Ritter, Philippe, additional, Lafitte, Stéphane, additional, and Réant, Patricia, additional

Published
2018
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146. Impact of operator experience and training strategy on procedural outcomes with leadless pacing: Insights from the Micra Transcatheter Pacing Study

Author

El-Chami, Mikhael, primary, Kowal, Robert C., additional, Soejima, Kyoko, additional, Ritter, Philippe, additional, Duray, Gabor Z., additional, Neuzil, Petr, additional, Mont, Lluis, additional, Kypta, Alexander, additional, Sagi, Venkata, additional, Hudnall, John Harrison, additional, Stromberg, Kurt, additional, and Reynolds, Dwight, additional

Published
2017
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147. Distinctive Left Ventricular Activations Associated With ECG Pattern in Heart Failure Patients

Author

Derval, Nicolas, primary, Duchateau, Josselin, additional, Mahida, Saagar, additional, Eschalier, Romain, additional, Sacher, Frederic, additional, Lumens, Joost, additional, Cochet, Hubert, additional, Denis, Arnaud, additional, Pillois, Xavier, additional, Yamashita, Seigo, additional, Komatsu, Yuki, additional, Ploux, Sylvain, additional, Amraoui, Sana, additional, Zemmoura, Adlane, additional, Ritter, Philippe, additional, Hocini, Mélèze, additional, Haissaguerre, Michel, additional, Jaïs, Pierre, additional, and Bordachar, Pierre, additional

Published
2017
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148. Prognostic value of the 12-lead surface electrocardiogram in sarcomeric hypertrophic cardiomyopathy: data from the REMY French register.

Author

Ledieu, Nicolas, Larnier, Louis, Auffret, Vincent, Marie, Coralie, Fargeau, Dominique, Donal, Erwan, Mirabel, Mariana, Jeunemaitre, Xavier, Puscas, Tania, Marijon, Eloi, Reynaud, Amélie, Ritter, Philippe, Lafitte, Stephane, Mabo, Philippe, Réant, Patricia, Daubert, Claude, Hagège, Albert A, Cardiology, REMY Working Group of the French Society of, and REMY Working Group of the French Society of Cardiology

Subjects
RESEARCH, CARDIAC hypertrophy, MUSCLES, RESEARCH methodology, PROGNOSIS, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, ELECTROCARDIOGRAPHY, HEART failure, DISEASE complications
Abstract

Aims: To identify independent electrocardiogram (ECG) predictors of long-term clinical outcome based on standardized analysis of the surface ECG in a large multicentre cohort of patients with sarcomeric hypertrophic cardiomyopathy (HCM).Methods and Results: Retrospective observational study from the REMY French HCM clinical research observatory. Primary endpoint was a composite of all-cause mortality, major non-fatal arrhythmic events, hospitalization for heart failure (HF), and stroke. Secondary endpoints were components of the primary endpoint. Uni- and multivariable Cox proportional hazard regression analysis was performed to identify independent predictors. Among 994 patients with HCM, only 1.8% had a strictly normal baseline ECG. The most prevalent abnormalities were inverted T waves (63.7%), P-wave abnormalities (30.4%), and abnormal Q waves (25.5%). During a mean follow-up of 4.0 ± 2.0 years, a total of 272 major cardiovascular events occurred in 217 patients (21.8%): death or heart transplant in 98 (9.8%), major arrhythmic events in 40 (4.0%), HF hospitalization in 115 (11.6%), and stroke in 23 (2.3%). At multivariable analysis using ECG covariates, prolonged QTc interval, low QRS voltage, and PVCs of right bundle branch block pattern predicted worse outcome, but none remained independently associated with the primary endpoint after adjustment on main demographic and clinical variables. For secondary endpoints, abnormal Q waves independently predicted all-cause death [hazard ratio (HR) 2.35, 95% confidence interval (CI) 1.23-4.47; P = 0.009] and prolonged QTc the risk of HF hospitalization (HR 1.006, 95% CI 1.001-1.011; P = 0.024).Conclusion: The 12-lead surface ECG has no independent value to predict the primary outcome measure in patients with HCM. The 12-lead surface ECG has been widely used as a screening tool in HCM but its prognostic value remains poorly known. The value of baseline surface ECG to predict long-term clinical outcomes was studied in a cohort of 994 patients with sarcomeric HCM. The surface ECG has no significant additional value to predict outcome in this patient population. [ABSTRACT FROM AUTHOR]

Published
2020
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149. Patient selection, pacing indications, and subsequent outcomes with de novo leadless single-chamber VVI pacing.

Author

Piccini, Jonathan P, Stromberg, Kurt, Jackson, Kevin P, Kowal, Robert C, Duray, Gabor Z, El-Chami, Mikhael F, Crossley, George H, Hummel, John D, Narasimhan, Calambur, Omar, Razali, Ritter, Philippe, Roberts, Paul R, Soejima, Kyoko, Reynolds, Dwight, Zhang, Shu, Steinwender, Clemens, Chinitz, Larry, Group, Micra Transcatheter Pacing Study, and Micra Transcatheter Pacing Study Group

Abstract

Aims: Patient selection is a key component of securing optimal patient outcomes with leadless pacing. We sought to describe and compare patient characteristics and outcomes of Micra patients with and without a primary pacing indication associated with atrial fibrillation (AF) in the Micra IDE trial.Methods and Results: The primary outcome (risk of cardiac failure, pacemaker syndrome, or syncope related to the Micra system or procedure) was compared between successfully implanted patients from the Micra IDE trial with a primary pacing indication associated with AF or history of AF (AF group) and those without (non-AF group). Among 720 patients successfully implanted with Micra, 228 (31.7%) were in the non-AF group. Reasons for selecting VVI pacing in non-AF patients included an expectation for infrequent pacing (66.2%) and advanced age (27.2%). More patients in the non-AF group had a condition that precluded the use of a transvenous pacemaker (9.6% vs. 4.7%, P = 0.013). Atrial fibrillation patients programmed to VVI received significantly more ventricular pacing compared to non-AF patients (median 67.8% vs. 12.6%; P < 0.001). The overall occurrence of the composite outcome at 24 months was 1.8% with no difference between the AF and non-AF groups (hazard ratio 1.36, 95% confidence interval 0.45-4.2; P = 0.59).Conclusion: Nearly one-third of patients selected to receive Micra VVI therapy were for indications not associated with AF. Non-AF VVI patients required less frequent pacing compared to patients with AF. Risks associated with VVI therapy were low and did not differ in those with and without AF. [ABSTRACT FROM AUTHOR]

Published
2019
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