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649 results on '"Raffoul, Wassim"'

102. Total Thumb Trapeziometacarpal Joint Arthroplasty: A Retrospective Study of 12 Prostheses Implanted with WALANT Technique

Author

Muller, Camillo Theo, Deboccard, Olivier, Christen, Thierry, Durand, Sébastien, and Raffoul, Wassim

Subjects
WALANT trapeziometacarpal joint prosthesis, ddc: 610, 610 Medical sciences, Medicine
Abstract

Objectives/Interrogation: De la Caffinière first described total trapeziometacarpal joint prosthesis in 1974 for treatment of the first carpometacarpal joint arthritis. Even though this technique is more expensive than trapeziectomy, it has some advantages such as faster convalescence. Since[for full text, please go to the a.m. URL], 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)

Published
2020
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105. Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCK[alpha] kinases

Author

Lefort, Karine, Mandinova, Anna, Ostano, Paola, Kolev, Vihren, Calpini, Valerie, Kolfschoten, Ingrid, Devgan, Vikram, Lieb, Jocelyn, Raffoul, Wassim, Hohl, Daniel, Neel, Victor, Garlick, Jonathan, Chiorino, Giovanna, and Dotto, Paolo, G.

Subjects
Cellular control mechanisms -- Research, Cancer -- Genetic aspects, Cancer -- Research, Biological sciences
Abstract

A study to show that Notch1 gene expression and activity are substantially down-modulated in keratinocyte cancer cell lines and tumors with its expression controlled by p53 was conducted. Results suggest that Notch1 gene is a p53 target in human keratinocytes with a role in tumor suppression of this cell type through negative regulation of the ROCK1/2 and MRCK[alpha] kinases.

Published
2007

113. Secret Scar Free Gracilis Flap

Author

Tremp, Mathias, Wettstein, Reto, Raffoul, Wassim, Schaefer, Dirk J., and Kalbermatten, Daniel F.

Published
2012

132. Lipedema: A Call to Action!

Author

Buso, Giacomo, primary, Depairon, Michele, additional, Tomson, Didier, additional, Raffoul, Wassim, additional, Vettor, Roberto, additional, and Mazzolai, Lucia, additional

Published
2019
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144. Efficient decellularization of equine tendon with preserved biomechanical properties and cytocompatibility for human tendon surgery indications.

Author

Aeberhard, Pierre‐Arnaud, Grognuz, Anthony, Peneveyre, Cédric, McCallin, Shawna, Hirt‐Burri, Nathalie, Antons, Jens, Pioletti, Dominique, Raffoul, Wassim, and Applegate, Lee Ann

Subjects
FLEXOR tendons, TENDONS, YOUNG'S modulus, TENDON injuries, CELLULAR therapy, PROGENITOR cells, CYTOCOMPATIBILITY
Abstract

Chronic and acute tendon injuries are frequent afflictions, for which treatment is often long and unsatisfactory. When facing extended injuries, matrices and scaffolds with sufficient biomechanical properties are required for surgical repair and could additionally serve as supports for cellular therapies to improve healing. In this study, protocols of either commonly used detergents only (SDS 1%, Triton 1%, TBP 1%, and Tween‐20 1%) or a combination of freeze/thaw (F/T) cycles with decellularization agents (NaCl 1M, ddH2O) were evaluated for the decellularization of horse equine superficial digital flexor tendon (SDFT) for hand flexor or extensor tendon reconstruction. Decellularization efficiency was assessed microscopically by histological staining (HE, DAPI) and DNA quantification. Macroscopical structure and biomechanical integrity of the tendon matrices were further assessed by gross observation, histological staining (SR), and mechanical testing (ultimate strain and stress, Young's modulus, energy to failure) for select protocols. Decellularization with hypertonic NaCl 1M in association with F/T cycles produced the most robust tendon matrices, which were nontoxic after 10 days for subsequent recellularization with human fetal progenitor tendon cells (hFPTs). This standardized protocol uses a less aggressive decellularization agent than current practice, which allows subsequent reseeding with allogenic cells, therefore making them very suitable and bioengineered tendon matrices for human tendon reconstruction in the clinic. [ABSTRACT FROM AUTHOR]

Published
2020
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