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Recently, two-dimensional (2D) magnets have drawn substantial attention from researchers for their fascinating properties and great application potential in the fields of biomedicine, data storage, signal transfer, and energy conversion. However, the low Curie/Néel temperature of 2D magnets hinders their application. In this Perspective, we present some physical insights into enhancing the magnetic stability of 2D magnets. First, the microscope theoretical model of 2D magnets is introduced. Then, we review and analyze several effective and commonly used methods for enhancing the magnetic stability of 2D magnets. Finally, we present the perspective and summary. This Perspective presents the advanced understanding of magnetic stability in 2D materials, which can provide new opportunities for further advancement in a wide variety of applications. [ABSTRACT FROM AUTHOR]

LGBT students continue to be vastly invisible in the international higher education literature and often face hostile learning environments, both in the classroom and in the larger university environment. This study follows a narrative inquiry approach to explore and document the experiences of tongzhi–the most widely embraced identity label among individuals romantically and sexually attracted to people of their same gender in contemporary Chinese societies–students in Mainland China. We interviewed six male university students who identify as tongzhi in order to understand their educational experience, the learning environments they experience in the classroom, and their interactions with the academic staff. Despite very different individual narratives, the findings reveal a resilient student population and a strategic approach to managing complex relationships and navigating self-disclosure. We offer recommendations for future research and for practitioners invested in promoting inclusive learning environments for all students. [ABSTRACT FROM AUTHOR]

Abstract Background and objective As the pathological mechanisms of AD are complex, increasing evidence have demonstrated Chinese Medicine with multi-ingredients and multi-targets may be more suitable for the treatment of diseases with complex pathogenesis. Therefore, the study was to preliminarily decipher the bioactive compounds and potential mechanisms of Qiong Yu Gao (QYG) for AD prevention and treatment by an integrated network pharmacology approach. Methods Putative ingredients of QYG and significant genes of AD were retrieved from public database after screening. Then QYG ingredients target proteins/genes were obtained by target fishing. Compound-target-disease network was constructed using Cytoscape to decipher the mechanism of QYG for AD. KEGG pathway and GO enrichment analysis were performed to investigate the molecular mechanisms and pathways related to QYG for AD treatments. Results Finally, 70 compounds and 511 relative drug targets were collected. In which, 17 representative direct targets were found. Gene ontology enrichment analysis revealed that the adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway was the key biological processes and were regulated simultaneously by the 17 direct targets. The KEGG pathway enrichment analysis found that three signaling pathways were closely related to AD prevention and treatment by QYG, including PI3K-Akt signaling pathway, regulation of actin cytoskeleton pathway and insulin resistance pathway. Conclusion This study demonstrated that QYG exerted the effect of preventing and treating AD by regulating multi-targets with multi-components. Furthermore, the study demonstrated that a network pharmacology-based approach was useful for elucidation of the interrelationship between complex diseases and interventions of Chinese herbal medicines.

The removal of reservoir silt and the restoration of existing reservoir capacities through land excavation and hydraulic sediment flushing have become necessary. Hydraulic sediment flushing discharge changes flow and sediment conditions of the downstream river channel. In the Tamsui River estuary in Taiwan, sediment flushing from the Shihmen reservoir upstream has potential impacts on the morphology of the navigation channels and the adjacent coasts. This study employed a validated coastal and estuarine processes model to investigate: (1) the influence of sediment flushing and tidal levels on morphological changes during flood and flushing-discharge operations of the reservoir, and (2) the differences in morphological changes on the estuary between monsoon and typhoon seasons. The prediction of the morphological changes was carried out by simulating hydrodynamic and morphodynamic processes under multi-year synthetic conditions combined by northeast monsoon and three historical typhoon events. The simulation results reveal that during the operation of sediment flushing when the peak discharge of river flood flow reaches the estuary section at ebb tides, more sediment can be transported to the open sea than that at flood tides. Additionally, the nature reserve area on the left bank of the estuary is eroded during monsoon and silted in typhoon seasons.