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1,161 results on '"Resino, Salvador"'

104. Antibody levels to SARS‐CoV ‐2 spike protein in mothers and children from delivery to six months later

Author

Martin‐Vicente, María, primary, Carrasco, Itziar, additional, Muñoz‐Gomez, María José, additional, Lobo, Alicia Hernanz, additional, Mas, Vicente, additional, Vigil‐Vázquez, Sara, additional, Vázquez, Mónica, additional, Manzanares, Angela, additional, Cano, Olga, additional, Alonso, Roberto, additional, Sepúlveda‐Crespo, Daniel, additional, Tarancón‐Díez, Laura, additional, Muñoz‐Fernández, María Ángeles, additional, Muñoz‐Chapuli, Mar, additional, Resino, Salvador, additional, Navarro, Maria Luisa, additional, and Martinez, Isidoro, additional

Published
2022
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105. Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control

Author

Masip, Jenifer, Rallón, Norma, Yeregui, Elena, Olona, Montserrat, Resino, Salvador, Benito, José Miguel, Viladés, Consuelo, García-Pardo, Graciano, Alcamí, José, Ruiz-Mateos, Ezequiel, Gómez-Bertomeu, Frederic, Vargas, Montserrat, Navarro, Marta, Oteo, José A, Pineda, Juan A, Martí, Anna, Alba, Verónica, Vidal, Francesc, Peraire, Joaquin, Rull, Anna, ECRIS integrated in the Spanish AIDS Research Network, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Red de Investigación Cooperativa en Investigación en Sida (España), Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas), Rovira i Virgili University (España), Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Unión Europea. Fondo Social Europeo (ESF/FSE), Agency for Administration of University and Research, Gilead Sciences (Spain), European Commission, Generalitat de Catalunya, Gilead Research Scholars, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Universidad Rovira i Virgili, Institut d'Investigació Sanitària Pere Virgili, and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica

Subjects
Mass spectrometry, Immunology, HIV Infections, HIV infection, Lipids, Long-term, Lipidomics, HIV-1, Immunology and Allergy, Metabolomics, Humans, Ketoglutaric Acids, Elite controllers (ECs), Viral, Kreb's cycle, Follow-Up Studies
Abstract

Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are still scarce, and hence, the metabolomics and lipidomics signatures in the LTEC-extreme phenotype, LTECs with more than 10 years of viral and immunological HIV control, could be pivotal to finding the keys for functional HIV remission. Metabolomics and lipidomics analyses were performed using high-resolution mass spectrometry (ultra-high-performance liquid chromatography-electrospray ionization-quadrupole time of flight [UHPLC-(ESI) qTOF] in plasma samples of 13 patients defined as LTEC-extreme, a group of 20 LTECs that lost viral and/or immunological control during the follow-up study (LTEC-losing) and 9 EC patients with short-term viral and immunological control (less than 5 years; no-LTEC patients). Long-term viral and immunological HIV-1 control was found to be strongly associated with elevated tricarboxylic acid (TCA) cycle function. Interestingly, of the nine metabolites identified in the TCA cycle, α-ketoglutaric acid (p = 0.004), a metabolite implicated in the activation of the mTOR complex, a modulator of HIV latency and regulator of several biological processes, was found to be a key metabolite in the persistent control. On the other hand, a lipidomics panel combining 45 lipid species showed an optimal percentage of separation and an ability to differentiate LTEC-extreme from LTEC-losing, revealing that an elevated lipidomics plasma profile could be a predictive factor for the reignition of viral replication in LTEC individuals., This work was supported by the Fondo de Investigación Sanitaria [PI13/0796, PI16/00503, PI16/0684, PI18/1532, PI19/00004, PI19/01127, PI19/01337 PI16/001769, PI19/00973, and PI20/00326]-ISCIII-FEDER (co-funded by the European Regional Development Fund/European Social Fund; “A way to make Europe”/”Investing in your future”); Programa de Suport als Grups de Recerca AGAUR (2017SGR948); Gilead Fellowship Program GLD14/293; The SPANISH AIDS Research Network [RD16/0002/0001, RD16/0002/0002, RD16/0025/0006, RD16/0025/0013, and RD16/0025/0020]-ISCIII-FEDER (Spain); and the Centro de Investigación Biomédica en Red de Enfermedades Infecciosas-ISCIII [CB21/13/00015, CB21/13/00020, and CB21/13/00044], Madrid, Spain. JM is supported by the Universitat Rovira I Virgili under grant agreement “2019PMF-PIPF-18,” through the call “Martí Franquès Research Fellowship Programme.” NR is a Miguel Servet researcher from the ISCIII [CPII19/00025]. EY is supported by the Instituto de Salud Carlos III (ISCIII) under grant agreement “FI20/0011800” through the program “Contratos Predoctorales de Formación en Investigación en Salud.” ER-M was supported by the Spanish National Research Council (CSIC). FV is supported by grants from the Programa de Intensificación de Investigadores (INT20/00031)-ISCIII and by “Premi a la Trajectòria Investigadora als Hospitals de l’ICS 2018.” AR is supported by IISPV through the project “2019/IISPV/05” (Boosting Young Talent), by GeSIDA through the “III Premio para Jóvenes Investigadores 2019,” and by the Instituto de Salud Carlos III (ISCIII) under grant agreement “CP19/00146” through the Miguel Servet Program.

Published
2022

112. Novel genes and sex differences in COVID-19 severity

Author

Cruz, Raquel, Diz-de Almeida, Silvia, López de Heredia, Miguel, Quintela, Inés, Ceballos, Francisco C, Pita, Guillermo, Lorenzo-Salazar, José M, González-Montelongo, Rafaela, Gago-Domínguez, Manuela, Sevilla Porras, Marta, Tenorio Castaño, Jair Antonio, Nevado, Julian, Aguado, Jose María, Aguilar, Carlos, Aguilera-Albesa, Sergio, Almadana, Virginia, Almoguera, Berta, Alvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, Arango, Celso, Arranz, María J, Artiga, Maria-Jesus, Baptista-Rosas, Raúl C, Barreda-Sánchez, María, Belhassen-Garcia, Moncef, Bezerra, Joao F, Bezerra, Marcos A C, Boix-Palop, Lucía, Brion, María, Brugada, Ramón, Bustos, Matilde, Calderón, Enrique J, Carbonell, Cristina, Castano, Luis, Castelao, Jose E, Conde-Vicente, Rosa, Cordero-Lorenzana, M Lourdes, Cortes-Sanchez, Jose L, Corton, Marta, Darnaude, M Teresa, De Martino-Rodríguez, Alba, Del Campo-Pérez, Victor, Diaz de Bustamante, Aranzazu, Domínguez-Garrido, Elena, Luchessi, Andre D, Eiros, Rocío, Estigarribia Sanabria, Gladys Mercedes, Carmen Fariñas, María, Fernández-Robelo, Uxía, Fernández-Rodríguez, Amanda, Fernández-Villa, Tania, Gil-Fournier, Belén, Gómez-Arrue, Javier, González Álvarez, Beatriz, Gonzalez Bernaldo de Quirós, Fernan, González-Peñas, Javier, Gutiérrez-Bautista, Juan F, Herrero, María José, Herrero-Gonzalez, Antonio, Jimenez-Sousa, María A, Lattig, María Claudia, Liger Borja, Anabel, Lopez-Rodriguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martinez-Nieto, Oscar, Martinez-Lopez, Iciar, Martinez-Resendez, Michel F, Martinez-Perez, Angel, Mazzeu, Juliana F, Merayo Macías, Eleuterio, Minguez, Pablo, Moreno Cuerda, Victor, Silbiger, Vivian N, Oliveira, Silviene F, Ortega-Paino, Eva, Parellada, Mara, Paz-Artal, Estela, Santos, Ney P C, Pérez-Matute, Patricia, Perez, Patricia, Pérez-Tomás, M Elena, Perucho, Teresa, Pinsach-Abuin, Mel Lina, Pompa-Mera, Ericka N, Porras-Hurtado, Gloria L, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R, Rodríguez-Ruiz, Emilio, Rodriguez-Artalejo, Fernando, Rodriguez-Garcia, José A, Ruiz Cabello, Francisco, Ruiz-Hornillos, Javier, Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Tamayo, Eduardo, Tamayo-Velasco, Alvaro, Taracido-Fernandez, Juan Carlos, Teper, Alejandro, Torres-Tobar, Lilian, Urioste, Miguel, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, Nakanishi, Tomoko, Pigazzini, Sara, Degenhardt, Frauke, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Palom, Adriana, Ellinghaus, David, Martínez-Bueno, Manuel, Rolker, Selina, Amitrano, Sara, Roade, Luisa, Fava, Francesca, Spinner, Christoph D, Prati, Daniele, Bernardo, David, Garcia, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Holter, Jan Cato, Banales, Jesus M, Frithiof, Robert, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C, Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, Hov, Johannes R, Migeotte, Isabelle, Renieri, Alessandra, Planas, Anna M, Ludwig, Kerstin U, Buti, Maria, Rahmouni, Souad, Alarcón-Riquelme, Marta E, Schulte, Eva C, Franke, Andre, Karlsen, Tom H, Valenti, Luca, Zeberg, Hugo, Richards, Brent, Ganna, Andrea, Boada, Mercè, de Rojas, Itziar, Ruiz, Agustín, Sánchez-Juan, Pascual, Real, Luis Miguel, Guillen-Navarro, Encarna, Ayuso, Carmen, González-Neira, Anna, Riancho, José A, Rojas-Martinez, Augusto, Flores, Carlos, Lapunzina, Pablo, Carracedo, Angel, Cruz, Raquel, Diz-de Almeida, Silvia, López de Heredia, Miguel, Quintela, Inés, Ceballos, Francisco C, Pita, Guillermo, Lorenzo-Salazar, José M, González-Montelongo, Rafaela, Gago-Domínguez, Manuela, Sevilla Porras, Marta, Tenorio Castaño, Jair Antonio, Nevado, Julian, Aguado, Jose María, Aguilar, Carlos, Aguilera-Albesa, Sergio, Almadana, Virginia, Almoguera, Berta, Alvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, Arango, Celso, Arranz, María J, Artiga, Maria-Jesus, Baptista-Rosas, Raúl C, Barreda-Sánchez, María, Belhassen-Garcia, Moncef, Bezerra, Joao F, Bezerra, Marcos A C, Boix-Palop, Lucía, Brion, María, Brugada, Ramón, Bustos, Matilde, Calderón, Enrique J, Carbonell, Cristina, Castano, Luis, Castelao, Jose E, Conde-Vicente, Rosa, Cordero-Lorenzana, M Lourdes, Cortes-Sanchez, Jose L, Corton, Marta, Darnaude, M Teresa, De Martino-Rodríguez, Alba, Del Campo-Pérez, Victor, Diaz de Bustamante, Aranzazu, Domínguez-Garrido, Elena, Luchessi, Andre D, Eiros, Rocío, Estigarribia Sanabria, Gladys Mercedes, Carmen Fariñas, María, Fernández-Robelo, Uxía, Fernández-Rodríguez, Amanda, Fernández-Villa, Tania, Gil-Fournier, Belén, Gómez-Arrue, Javier, González Álvarez, Beatriz, Gonzalez Bernaldo de Quirós, Fernan, González-Peñas, Javier, Gutiérrez-Bautista, Juan F, Herrero, María José, Herrero-Gonzalez, Antonio, Jimenez-Sousa, María A, Lattig, María Claudia, Liger Borja, Anabel, Lopez-Rodriguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martinez-Nieto, Oscar, Martinez-Lopez, Iciar, Martinez-Resendez, Michel F, Martinez-Perez, Angel, Mazzeu, Juliana F, Merayo Macías, Eleuterio, Minguez, Pablo, Moreno Cuerda, Victor, Silbiger, Vivian N, Oliveira, Silviene F, Ortega-Paino, Eva, Parellada, Mara, Paz-Artal, Estela, Santos, Ney P C, Pérez-Matute, Patricia, Perez, Patricia, Pérez-Tomás, M Elena, Perucho, Teresa, Pinsach-Abuin, Mel Lina, Pompa-Mera, Ericka N, Porras-Hurtado, Gloria L, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R, Rodríguez-Ruiz, Emilio, Rodriguez-Artalejo, Fernando, Rodriguez-Garcia, José A, Ruiz Cabello, Francisco, Ruiz-Hornillos, Javier, Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Tamayo, Eduardo, Tamayo-Velasco, Alvaro, Taracido-Fernandez, Juan Carlos, Teper, Alejandro, Torres-Tobar, Lilian, Urioste, Miguel, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, Nakanishi, Tomoko, Pigazzini, Sara, Degenhardt, Frauke, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Palom, Adriana, Ellinghaus, David, Martínez-Bueno, Manuel, Rolker, Selina, Amitrano, Sara, Roade, Luisa, Fava, Francesca, Spinner, Christoph D, Prati, Daniele, Bernardo, David, Garcia, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Holter, Jan Cato, Banales, Jesus M, Frithiof, Robert, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C, Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, Hov, Johannes R, Migeotte, Isabelle, Renieri, Alessandra, Planas, Anna M, Ludwig, Kerstin U, Buti, Maria, Rahmouni, Souad, Alarcón-Riquelme, Marta E, Schulte, Eva C, Franke, Andre, Karlsen, Tom H, Valenti, Luca, Zeberg, Hugo, Richards, Brent, Ganna, Andrea, Boada, Mercè, de Rojas, Itziar, Ruiz, Agustín, Sánchez-Juan, Pascual, Real, Luis Miguel, Guillen-Navarro, Encarna, Ayuso, Carmen, González-Neira, Anna, Riancho, José A, Rojas-Martinez, Augusto, Flores, Carlos, Lapunzina, Pablo, and Carracedo, Angel

Abstract

Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.

Published
2022
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113. Supplementary files of the article 'Novel genes and sex differences in COVID-19 severity' [Dataset]

Author

Cruz Modino, Raquel de la, Diz-de Almeida, Silvia, López de Heredia, Miguel, Quintela, Inés, Ceballos, Francisco C., Pita, Guillermo, Lorenzo-Salazar, José M., González-Montelongo, Rafaela, Gago-Dominguez, Manuela, Sevilla Porras, Marta, Tenorio Castaño, Jair Antonio, Carbonell, Cristina, Migeotte, Isabelle, Renieri, Alessandra, Aguilera-Albesa, Sergio, Planas, Anna M., Ludwig, Kerstin U., Buti, María, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Tamayo-Velasco, Álvaro, Franke, Andre, Castaño, Luis, Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Almadana Pacheco, Virginia, Richards, Brent, Ganna, Andrea, Boada, Mercè, Rojas, Itziar de, Gil-Fournier, Belén, Ruiz, Agustín, Sánchez-Juan, Pascual, Castelao, Jose E., Real, Luis Miguel, SCOURGE Cohort Group, HOSTAGE Cohort Group, GRA@CE Cohort Group, Almoguera, Berta, Guillen-Navarro, Encarna, Ayuso, Carmen, Gómez-Arrue, Javier, González-Neira, Anna, Riancho, José A., Rojas-Martinez, Augusto, Conde-Vicente, Rosa, Flores, Carlos, Lapunzina, Pablo, Carracedo, Ángel, Álvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, González Álvarez, Beatriz, Arango, Celso, Arranz, Maria J., Artiga, María Jesús, Baptista-Rosas, Raúl C., Cordero-Lorenzana, M. Lourdes, Barreda-Sánchez, María, Belhassen-García, Moncef, Bezerra, Joao F., Bezerra, Marcos A. C., Boix-Palop, Lucía, Gonzalez Bernaldo de Quirós, Fernán, Briones, María, Brugada, Ramón, Bustos, Matilde, Cortés-Sánchez, José L., Cortón, Marta, Darnaude, M. Teresa, Martino-Rodríguez, Alba de, Tamayo, Eduardo, Campo-Pérez, Víctor de, Diaz de Bustamante, Aranzazu, González-Peñas, Javier, Domínguez-Garrido, Elena, Luchessi, Andre D., Eiros, Rocío, Estigarribia Sanabria, Gladys Mercedes, Fariñas, María del Carmen, Fernández-Robelo, Uxía, Fernández-Rodríguez, Amanda, Fernández-Villa, Tania, Gutiérrez-Bautista, Juan F., Herrero, María José, Herrero-Gonzalez, Antonio, Jiménez-Sousa, María A., Aguado, José María, Lattig, María Claudia, Taracido-Fernandez, Juan Carlos, Liger Borja, Anabel, López-Rodríguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martínez-Nieto, Oscar, Martinez-López, Icíar, Martinez-Resendez, Michel F., Amitrano, Sara, Martínez-Pérez, Àngel, Mazzeu, Juliana F, Teper, Alejandro, Merayo Macías, Eleuterio, Mínguez, Pablo, Moreno Cuerda, Víctor, Silbiger, Vivian N., Oliveira, Silviene F., Ortega-Paino, Eva, Parellada, Mara, Roade, Luisa, Paz-Artal, Estela, Santos, Ney P. C., Pérez-Matute, Patricia, Torres-Tobar, Lilian, Pérez Ramírez, Patricia, Pérez-Tomás, M. Elena, Perucho, Teresa, Pinsach-Abuin, Mel Lina, Pompa-Mera, Ericka N., Porras-Hurtado, Gloria L., Fava, Francesca, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R., Urioste, Miguel, Rodríguez-Ruiz, Emilio, Rodríguez-Artalejo, Fernando, Rodríguez-García, José A, Ruiz Cabello, Francisco, Ruiz-Hornillos, Javier, Spinner, Christoph D., Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, Nakanishi, Tomoko, Nevado, Julian, Pigazzini, Sara, Degenhardt, Frauke, Prati, Daniele, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Palom, Adriana, Ellinghaus, David, Martínez-Bueno, Manuel, Rolker, Selina, Bernardo, David, García, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Calderón, Enrique J., Holter, Jan Cato, Aguilar, Carlos, Banales, Jesús M., Frithiof, Robert, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C., Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, Hov, Johannes R., Cruz Modino, Raquel de la, Diz-de Almeida, Silvia, López de Heredia, Miguel, Quintela, Inés, Ceballos, Francisco C., Pita, Guillermo, Lorenzo-Salazar, José M., González-Montelongo, Rafaela, Gago-Dominguez, Manuela, Sevilla Porras, Marta, Tenorio Castaño, Jair Antonio, Carbonell, Cristina, Migeotte, Isabelle, Renieri, Alessandra, Aguilera-Albesa, Sergio, Planas, Anna M., Ludwig, Kerstin U., Buti, María, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Tamayo-Velasco, Álvaro, Franke, Andre, Castaño, Luis, Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Almadana Pacheco, Virginia, Richards, Brent, Ganna, Andrea, Boada, Mercè, Rojas, Itziar de, Gil-Fournier, Belén, Ruiz, Agustín, Sánchez-Juan, Pascual, Castelao, Jose E., Real, Luis Miguel, SCOURGE Cohort Group, HOSTAGE Cohort Group, GRA@CE Cohort Group, Almoguera, Berta, Guillen-Navarro, Encarna, Ayuso, Carmen, Gómez-Arrue, Javier, González-Neira, Anna, Riancho, José A., Rojas-Martinez, Augusto, Conde-Vicente, Rosa, Flores, Carlos, Lapunzina, Pablo, Carracedo, Ángel, Álvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, González Álvarez, Beatriz, Arango, Celso, Arranz, Maria J., Artiga, María Jesús, Baptista-Rosas, Raúl C., Cordero-Lorenzana, M. Lourdes, Barreda-Sánchez, María, Belhassen-García, Moncef, Bezerra, Joao F., Bezerra, Marcos A. C., Boix-Palop, Lucía, Gonzalez Bernaldo de Quirós, Fernán, Briones, María, Brugada, Ramón, Bustos, Matilde, Cortés-Sánchez, José L., Cortón, Marta, Darnaude, M. Teresa, Martino-Rodríguez, Alba de, Tamayo, Eduardo, Campo-Pérez, Víctor de, Diaz de Bustamante, Aranzazu, González-Peñas, Javier, Domínguez-Garrido, Elena, Luchessi, Andre D., Eiros, Rocío, Estigarribia Sanabria, Gladys Mercedes, Fariñas, María del Carmen, Fernández-Robelo, Uxía, Fernández-Rodríguez, Amanda, Fernández-Villa, Tania, Gutiérrez-Bautista, Juan F., Herrero, María José, Herrero-Gonzalez, Antonio, Jiménez-Sousa, María A., Aguado, José María, Lattig, María Claudia, Taracido-Fernandez, Juan Carlos, Liger Borja, Anabel, López-Rodríguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martínez-Nieto, Oscar, Martinez-López, Icíar, Martinez-Resendez, Michel F., Amitrano, Sara, Martínez-Pérez, Àngel, Mazzeu, Juliana F, Teper, Alejandro, Merayo Macías, Eleuterio, Mínguez, Pablo, Moreno Cuerda, Víctor, Silbiger, Vivian N., Oliveira, Silviene F., Ortega-Paino, Eva, Parellada, Mara, Roade, Luisa, Paz-Artal, Estela, Santos, Ney P. C., Pérez-Matute, Patricia, Torres-Tobar, Lilian, Pérez Ramírez, Patricia, Pérez-Tomás, M. Elena, Perucho, Teresa, Pinsach-Abuin, Mel Lina, Pompa-Mera, Ericka N., Porras-Hurtado, Gloria L., Fava, Francesca, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R., Urioste, Miguel, Rodríguez-Ruiz, Emilio, Rodríguez-Artalejo, Fernando, Rodríguez-García, José A, Ruiz Cabello, Francisco, Ruiz-Hornillos, Javier, Spinner, Christoph D., Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, Nakanishi, Tomoko, Nevado, Julian, Pigazzini, Sara, Degenhardt, Frauke, Prati, Daniele, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Palom, Adriana, Ellinghaus, David, Martínez-Bueno, Manuel, Rolker, Selina, Bernardo, David, García, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Calderón, Enrique J., Holter, Jan Cato, Aguilar, Carlos, Banales, Jesús M., Frithiof, Robert, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C., Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, and Hov, Johannes R.

Published
2022

114. Novel genes and sex differences in COVID-19 severity

Author

Instituto de Salud Carlos III, European Commission, Fundación Amancio Ortega, Banco Santander, Estrella de Levante, Colabora Mujer, Fundación Canaria Instituto de Investigación Sanitaria de Canarias, Cruz Modino, Raquel de la, Diz-de Almeida, Silvia, López de Heredia, Miguel, Quintela, Inés, Ceballos, Francisco C., Pita, Guillermo, Lorenzo-Salazar, José M., González-Montelongo, Rafaela, Gago-Dominguez, Manuela, Sevilla Porras, Marta, Tenorio Castaño, Jair Antonio, Carbonell, Cristina, Migeotte, Isabelle, Renieri, Alessandra, Aguilera-Albesa, Sergio, Planas, Anna M., Ludwig, Kerstin U., Buti, María, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Tamayo-Velasco, Álvaro, Franke, Andre, Castaño, Luis, Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Almadana Pacheco, Virginia, Richards, Brent, Ganna, Andrea, Boada, Mercè, Rojas, Itziar de, Gil-Fournier, Belén, Ruiz, Agustín, Sánchez-Juan, Pascual, Castelao, Jose E., Real, Luis Miguel, SCOURGE Cohort Group, HOSTAGE Cohort Group, GRA@CE Cohort Group, Almoguera, Berta, Guillen-Navarro, Encarna, Ayuso, Carmen, Gómez-Arrue, Javier, González-Neira, Anna, Riancho, José A., Rojas-Martinez, Augusto, Conde-Vicente, Rosa, Flores, Carlos, Lapunzina, Pablo, Carracedo, Ángel, Álvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, González Álvarez, Beatriz, Arango, Celso, Arranz, Maria J., Artiga, María Jesús, Baptista-Rosas, Raúl C., Cordero-Lorenzana, M. Lourdes, Barreda-Sánchez, María, Belhassen-García, Moncef, Bezerra, Joao F., Bezerra, Marcos A. C., Boix-Palop, Lucía, Gonzalez Bernaldo de Quirós, Fernán, Briones, María, Brugada, Ramón, Bustos, Matilde, Cortés-Sánchez, José L., Cortón, Marta, Darnaude, M. Teresa, Martino-Rodríguez, Alba de, Tamayo, Eduardo, Campo-Pérez, Víctor de, Diaz de Bustamante, Aranzazu, González-Peñas, Javier, Domínguez-Garrido, Elena, Luchessi, Andre D., Eiros, Rocío, Estigarribia Sanabria, Gladys Mercedes, Fariñas, María del Carmen, Fernández-Robelo, Uxía, Fernández-Rodríguez, Amanda, Fernández-Villa, Tania, Gutiérrez-Bautista, Juan F., Herrero, María José, Herrero-Gonzalez, Antonio, Jiménez-Sousa, María A., Aguado, José María, Lattig, María Claudia, Taracido-Fernandez, Juan Carlos, Liger Borja, Anabel, López-Rodríguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martínez-Nieto, Oscar, Martinez-López, Icíar, Martinez-Resendez, Michel F., Amitrano, Sara, Martínez-Pérez, Àngel, Mazzeu, Juliana F, Teper, Alejandro, Merayo Macías, Eleuterio, Mínguez, Pablo, Moreno Cuerda, Víctor, Silbiger, Vivian N., Oliveira, Silviene F., Ortega-Paino, Eva, Parellada, Mara, Roade, Luisa, Paz-Artal, Estela, Santos, Ney P. C., Pérez-Matute, Patricia, Torres-Tobar, Lilian, Pérez Ramírez, Patricia, Pérez-Tomás, M. Elena, Perucho, Teresa, Pinsach-Abuin, Mel Lina, Pompa-Mera, Ericka N., Porras-Hurtado, Gloria L., Fava, Francesca, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R., Urioste, Miguel, Rodríguez-Ruiz, Emilio, Rodríguez-Artalejo, Fernando, Rodríguez-García, José A, Ruiz Cabello, Francisco, Ruiz-Hornillos, Javier, Spinner, Christoph D., Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, Nakanishi, Tomoko, Nevado, Julian, Pigazzini, Sara, Degenhardt, Frauke, Prati, Daniele, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Palom, Adriana, Ellinghaus, David, Martínez-Bueno, Manuel, Rolker, Selina, Bernardo, David, García, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Calderón, Enrique J., Holter, Jan Cato, Aguilar, Carlos, Banales, Jesús M., Frithiof, Robert, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C., Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, Hov, Johannes R., Instituto de Salud Carlos III, European Commission, Fundación Amancio Ortega, Banco Santander, Estrella de Levante, Colabora Mujer, Fundación Canaria Instituto de Investigación Sanitaria de Canarias, Cruz Modino, Raquel de la, Diz-de Almeida, Silvia, López de Heredia, Miguel, Quintela, Inés, Ceballos, Francisco C., Pita, Guillermo, Lorenzo-Salazar, José M., González-Montelongo, Rafaela, Gago-Dominguez, Manuela, Sevilla Porras, Marta, Tenorio Castaño, Jair Antonio, Carbonell, Cristina, Migeotte, Isabelle, Renieri, Alessandra, Aguilera-Albesa, Sergio, Planas, Anna M., Ludwig, Kerstin U., Buti, María, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Tamayo-Velasco, Álvaro, Franke, Andre, Castaño, Luis, Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Almadana Pacheco, Virginia, Richards, Brent, Ganna, Andrea, Boada, Mercè, Rojas, Itziar de, Gil-Fournier, Belén, Ruiz, Agustín, Sánchez-Juan, Pascual, Castelao, Jose E., Real, Luis Miguel, SCOURGE Cohort Group, HOSTAGE Cohort Group, GRA@CE Cohort Group, Almoguera, Berta, Guillen-Navarro, Encarna, Ayuso, Carmen, Gómez-Arrue, Javier, González-Neira, Anna, Riancho, José A., Rojas-Martinez, Augusto, Conde-Vicente, Rosa, Flores, Carlos, Lapunzina, Pablo, Carracedo, Ángel, Álvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, González Álvarez, Beatriz, Arango, Celso, Arranz, Maria J., Artiga, María Jesús, Baptista-Rosas, Raúl C., Cordero-Lorenzana, M. Lourdes, Barreda-Sánchez, María, Belhassen-García, Moncef, Bezerra, Joao F., Bezerra, Marcos A. C., Boix-Palop, Lucía, Gonzalez Bernaldo de Quirós, Fernán, Briones, María, Brugada, Ramón, Bustos, Matilde, Cortés-Sánchez, José L., Cortón, Marta, Darnaude, M. Teresa, Martino-Rodríguez, Alba de, Tamayo, Eduardo, Campo-Pérez, Víctor de, Diaz de Bustamante, Aranzazu, González-Peñas, Javier, Domínguez-Garrido, Elena, Luchessi, Andre D., Eiros, Rocío, Estigarribia Sanabria, Gladys Mercedes, Fariñas, María del Carmen, Fernández-Robelo, Uxía, Fernández-Rodríguez, Amanda, Fernández-Villa, Tania, Gutiérrez-Bautista, Juan F., Herrero, María José, Herrero-Gonzalez, Antonio, Jiménez-Sousa, María A., Aguado, José María, Lattig, María Claudia, Taracido-Fernandez, Juan Carlos, Liger Borja, Anabel, López-Rodríguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martínez-Nieto, Oscar, Martinez-López, Icíar, Martinez-Resendez, Michel F., Amitrano, Sara, Martínez-Pérez, Àngel, Mazzeu, Juliana F, Teper, Alejandro, Merayo Macías, Eleuterio, Mínguez, Pablo, Moreno Cuerda, Víctor, Silbiger, Vivian N., Oliveira, Silviene F., Ortega-Paino, Eva, Parellada, Mara, Roade, Luisa, Paz-Artal, Estela, Santos, Ney P. C., Pérez-Matute, Patricia, Torres-Tobar, Lilian, Pérez Ramírez, Patricia, Pérez-Tomás, M. Elena, Perucho, Teresa, Pinsach-Abuin, Mel Lina, Pompa-Mera, Ericka N., Porras-Hurtado, Gloria L., Fava, Francesca, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R., Urioste, Miguel, Rodríguez-Ruiz, Emilio, Rodríguez-Artalejo, Fernando, Rodríguez-García, José A, Ruiz Cabello, Francisco, Ruiz-Hornillos, Javier, Spinner, Christoph D., Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, Nakanishi, Tomoko, Nevado, Julian, Pigazzini, Sara, Degenhardt, Frauke, Prati, Daniele, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Palom, Adriana, Ellinghaus, David, Martínez-Bueno, Manuel, Rolker, Selina, Bernardo, David, García, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Calderón, Enrique J., Holter, Jan Cato, Aguilar, Carlos, Banales, Jesús M., Frithiof, Robert, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C., Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, and Hov, Johannes R.

Abstract

Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10-22 and P = 8.1 × 10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10-8) and ARHGAP33 (P = 1.3 × 10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.

Published
2022

115. DBP rs7041 and DHCR7 rs3829251 are Linked to CD4(+) Recovery in HIV Patients on Antiretroviral Therapy

Author

Universitat Rovira i Virgili, Resino, Salvador; Jimenez-Sousa, Maria Angeles; Blanco, Julia; Pacheco, Yolanda M.; del Romero, Jorge; Peraire, Joaquim; Virseda-Berdices, Ana; Munoz-Gomez, Maria Jose; Galera-Penaranda, Carlos; Garcia-Fraile, Lucio Jesus; Benito, Jose M.; Rallon, Norma;Epiclin, SARNPR, Universitat Rovira i Virgili, and Resino, Salvador; Jimenez-Sousa, Maria Angeles; Blanco, Julia; Pacheco, Yolanda M.; del Romero, Jorge; Peraire, Joaquim; Virseda-Berdices, Ana; Munoz-Gomez, Maria Jose; Galera-Penaranda, Carlos; Garcia-Fraile, Lucio Jesus; Benito, Jose M.; Rallon, Norma;Epiclin, SARNPR

Abstract

Background: The lack of the recovery of CD4(+) T-cells (CD4(+) recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known. We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4(+) recovery in naive HIV-infected patients who started ART with low baseline CD4(+).Methods: We conducted a retrospective study in 411 naive individuals with plasma HIV load >200 copies/mL and CD4(+) <200 cells/mm(3). During 24 months of follow-up, all patients had plasma HIV load Results: CD4(+) recovery was higher in patients carrying DBP rs7041 AA genotype (AA versus CC/AC) and DHCR7 rs3829251 AA genotype (AA versus GG/AG) (p-value < 0.05). DBP rs7041 AA genotype was linked to increase in CD4(+) (adjusted arithmetic mean ratio (aAMR) = 1.22; q-value = 0.011), increase in CD4(+) >= P75th [adjusted odds ratio (aOR) = 2.31; q-value = 0.005], slope of CD4(+) recovery (aAMR = 1.25; q-value = 0.008), slope of CD4(+) recovery >= P75th (aOR = 2.55; q-value = 0.005) and achievement of CD4(+) >= 500 cells/mm(3) (aOR = 1.89; q-value = 0.023). Besides, DHCR7 rs3829251 AA genotype was related to increase in CD4(+) (aAMR = 1.43; q-value = 0.031), increase in CD4(+) >= P75th (aOR = 3.92; q-value = 0.030), slope of CD4(+) recovery (aAMR = 1.40; q-value = 0.036), slope of CD4(+) recovery >= P75th (aOR = 3.42; q-value = 0.031) and achievement of CD4(+) >= 500 cells/mm(3) (aOR = 5.68; q-value = 0.015).Conclusion: In summary, DHCR7 rs3829251 and DBP rs7041 polymorphisms were associated with CD4(+) recovery in HIV-infected patients who started cART with low CD4(+) T-cell counts.

Published
2022

116. Similar humoral immune responses against the SARS-CoV-2 spike protein in HIV and non-HIV individuals after COVID-19

Author

Martín-Vicente, María, Berenguer, Juan, Muñoz-Gómez, María José, Díez, Cristina, Micán, Rafael, Pérez-Elías, María Jesús, García-Fraile, Lucio Jesús, Peraire, Joaquin, Suárez-García, Inés, Jiménez-Sousa, María Ángeles, Fernández-Rodríguez, Amanda, Vázquez, Mónica, Ryan, Pablo, González-García, Juan, Jarrín, Inmaculada, Mas, Vicente, Martínez, Isidoro, and Resino, Salvador

Published
2022
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120. Metabolic Profiling at COVID-19 Onset Shows Disease Severity and Sex-Specific Dysregulation

Author

Ceballos, Francisco C., primary, Virseda-Berdices, Ana, additional, Resino, Salvador, additional, Ryan, Pablo, additional, Martínez-González, Oscar, additional, Peréz-García, Felipe, additional, Martin-Vicente, María, additional, Brochado-Kith, Oscar, additional, Blancas, Rafael, additional, Bartolome-Sánchez, Sofía, additional, Vidal-Alcántara, Erick Joan, additional, Albóniga-Díez, Oihane Elena, additional, Cuadros-González, Juan, additional, Blanca-López, Natalia, additional, Martínez, Isidoro, additional, Martinez-Acitores, Ignacio Ramirez, additional, Barbas, Coral, additional, Fernández-Rodríguez, Amanda, additional, and Jiménez-Sousa, María Ángeles, additional

Published
2022
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121. Hepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia: A Case-Control Study

Author

Pérez-García, Felipe, primary, Vázquez-Morón, Sonia, additional, Burgueño-García, Iván, additional, Muñoz-Gómez, María José, additional, Zea-Sevilla, María Ascensión, additional, Calero, Miguel, additional, Martínez, Isidoro, additional, Rábano, Alberto, additional, and Resino, Salvador, additional

Published
2022
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122. Negative impact of HIV infection on broad-spectrum anti-HCV neutralizing antibody titers in HCV-infected patients with advanced HCV-related cirrhosis

Author

Sepúlveda-Crespo, Daniel, primary, Yélamos, María Belén, additional, Díez, Cristina, additional, Gómez, Julián, additional, Hontañón, Víctor, additional, Torresano-Felipe, Francisco, additional, Berenguer, Juan, additional, González-García, Juan, additional, Ibañez-Samaniego, Luis, additional, Llop, Elva, additional, Olveira, Antonio, additional, Martínez, Javier, additional, Resino, Salvador, additional, and Martínez, Isidoro, additional

Published
2022
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123. Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control

Author

Masip, Jenifer, primary, Rallón, Norma, additional, Yeregui, Elena, additional, Olona, Montserrat, additional, Resino, Salvador, additional, Benito, José M., additional, Viladés, Consuelo, additional, García-Pardo, Graciano, additional, Alcamí, José, additional, Ruiz-Mateos, Ezequiel, additional, Gómez-Bertomeu, Frederic, additional, Vargas, Montserrat, additional, Navarro, Marta, additional, Oteo, José A., additional, Pineda, Juan A., additional, Martí, Anna, additional, Alba, Verónica, additional, Vidal, Francesc, additional, Peraire, Joaquin, additional, and Rull, Anna, additional

Published
2022
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124. High Plasma sTNF-R1 Level Is Related to Loss of Natural HIV Control in Long-Term Elite Controllers

Author

Sepulveda-Crespo, Daniel, Rallón, Norma, Muñoz-Gómez, María José, Brochado-Kith, Oscar, Jiménez, José Luis, Muñoz-Fernández, María Ángeles, Benito, José Miguel, Resino, Salvador, ECRIS Integrated in the Spanish AIDS Research Network, Red de Investigación Cooperativa en Investigación en Sida (España), Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas), and Instituto de Salud Carlos III

Subjects
Microbiology (medical), Inflammation, Immunology, AIDS progression, HIV Infections, Viral Load, Microbiology, Long-term elite controllers, Infectious Diseases, HIV-1, Humans, Plasma biomarkers, Elite Controllers, Retrospective Studies
Abstract

Human immunodeficiency virus-1 (HIV-1) elite controllers are heterogeneous due to different immunovirological features. We aimed to identify plasma biomarkers associated with loss of spontaneous HIV-1 control in long-term elite controllers (HIV-LTECs). We performed a retrospective study in 60 HIV-LTECs [36 true-LTECs and 24 LTECs losing control (LTECs-LC)]. We selected a plasma sample from true-LTECs (towards the middle of the follow-up period) and two samples from LTECs-LC (one far from the loss of control and another close to loss of control). Plasma biomarkers were evaluated using multiplex immunoassays. The partial least squares-discriminant analysis provided the variable importance in projection (VIP), and the adjusted Generalized Linear Model provided the adjusted arithmetic mean ratio (aAMR). At the moment of the first LTECs-LC samples, the only plasma biomarker with a VIP≥1.5 was sTNF-R1, which showed higher values in LTECs-LC than true-LTECs [aAMR=1.62 (95%CI=1.20-2.19); p=0.001]. After a median of 3.9 (IQR=4.5) years of follow-up from the first sample, we also had access to a second plasma sample from 10 LTECs-LC patients. At the moment of this second LTECs-LC sample, the only plasma biomarker with VIP≥1.5 was also sTNF-R1, which showed higher values in LTECs-LC than true-LTECs [aAMR=1.93 (95%CI=1.41-2.65); p

Published
2022

125. sj-docx-6-joh-10.1177_00207314211012357 - Supplemental material for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study

Author

Ortega-Loubon, Christian, Ruiz López del Prado, Gema, Muñoz-Moreno, María F., Gómez-Sánchez, Esther, López-Herrero, Rocío, Sánchez-Quirós, Belén, Lorenzo-Lopez, Mario, Gómez-Pesquera, Estefanía, Jorge-Monjas, Pablo, Bustamante-Munguira, Juan, Álvarez, F. Javier, Resino, Salvador, Tamayo, Eduardo, and Heredia-Rodríguez, María

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-6-joh-10.1177_00207314211012357 for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study by Christian Ortega-Loubon, Gema Ruiz López del Prado, María F. Muñoz-Moreno, Esther Gómez-Sánchez, Rocío López-Herrero, Belén Sánchez-Quirós, Mario Lorenzo-Lopez, Estefanía Gómez-Pesquera, Pablo Jorge-Monjas, Juan Bustamante-Munguira, F. Javier Álvarez, Salvador Resino, Eduardo Tamayo and María Heredia-Rodríguez in International Journal of Health Services

Published
2022
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126. Additional file 2 of Neighborhood environmental factors linked to hospitalizations of older people for viral lower respiratory tract infections in Spain: a case-crossover study

Author

Álvaro-Meca, Alejandro, Sepúlveda-Crespo, Daniel, Resino, Rosa, Ryan, Pablo, Martínez, Isidoro, and Resino, Salvador

Abstract

Additional file 2: Supplementary Table 2. Summary of adjusted associations between ambient air pollutants and hospital admissions for lower respiratory tract viral infections in Spain (2013–2015).

Published
2022
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127. sj-docx-4-joh-10.1177_00207314211012357 - Supplemental material for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study

Author

Ortega-Loubon, Christian, Ruiz López del Prado, Gema, Muñoz-Moreno, María F., Gómez-Sánchez, Esther, López-Herrero, Rocío, Sánchez-Quirós, Belén, Lorenzo-Lopez, Mario, Gómez-Pesquera, Estefanía, Jorge-Monjas, Pablo, Bustamante-Munguira, Juan, Álvarez, F. Javier, Resino, Salvador, Tamayo, Eduardo, and Heredia-Rodríguez, María

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-4-joh-10.1177_00207314211012357 for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study by Christian Ortega-Loubon, Gema Ruiz López del Prado, María F. Muñoz-Moreno, Esther Gómez-Sánchez, Rocío López-Herrero, Belén Sánchez-Quirós, Mario Lorenzo-Lopez, Estefanía Gómez-Pesquera, Pablo Jorge-Monjas, Juan Bustamante-Munguira, F. Javier Álvarez, Salvador Resino, Eduardo Tamayo and María Heredia-Rodríguez in International Journal of Health Services

Published
2022
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128. sj-docx-2-joh-10.1177_00207314211012357 - Supplemental material for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study

Author

Ortega-Loubon, Christian, Ruiz López del Prado, Gema, Muñoz-Moreno, María F., Gómez-Sánchez, Esther, López-Herrero, Rocío, Sánchez-Quirós, Belén, Lorenzo-Lopez, Mario, Gómez-Pesquera, Estefanía, Jorge-Monjas, Pablo, Bustamante-Munguira, Juan, Álvarez, F. Javier, Resino, Salvador, Tamayo, Eduardo, and Heredia-Rodríguez, María

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-2-joh-10.1177_00207314211012357 for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study by Christian Ortega-Loubon, Gema Ruiz López del Prado, María F. Muñoz-Moreno, Esther Gómez-Sánchez, Rocío López-Herrero, Belén Sánchez-Quirós, Mario Lorenzo-Lopez, Estefanía Gómez-Pesquera, Pablo Jorge-Monjas, Juan Bustamante-Munguira, F. Javier Álvarez, Salvador Resino, Eduardo Tamayo and María Heredia-Rodríguez in International Journal of Health Services

Published
2022
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130. sj-docx-3-joh-10.1177_00207314211012357 - Supplemental material for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study

Author

Ortega-Loubon, Christian, Ruiz López del Prado, Gema, Muñoz-Moreno, María F., Gómez-Sánchez, Esther, López-Herrero, Rocío, Sánchez-Quirós, Belén, Lorenzo-Lopez, Mario, Gómez-Pesquera, Estefanía, Jorge-Monjas, Pablo, Bustamante-Munguira, Juan, Álvarez, F. Javier, Resino, Salvador, Tamayo, Eduardo, and Heredia-Rodríguez, María

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-3-joh-10.1177_00207314211012357 for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study by Christian Ortega-Loubon, Gema Ruiz López del Prado, María F. Muñoz-Moreno, Esther Gómez-Sánchez, Rocío López-Herrero, Belén Sánchez-Quirós, Mario Lorenzo-Lopez, Estefanía Gómez-Pesquera, Pablo Jorge-Monjas, Juan Bustamante-Munguira, F. Javier Álvarez, Salvador Resino, Eduardo Tamayo and María Heredia-Rodríguez in International Journal of Health Services

Published
2022
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131. sj-docx-5-joh-10.1177_00207314211012357 - Supplemental material for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study

Author

Ortega-Loubon, Christian, Ruiz López del Prado, Gema, Muñoz-Moreno, María F., Gómez-Sánchez, Esther, López-Herrero, Rocío, Sánchez-Quirós, Belén, Lorenzo-Lopez, Mario, Gómez-Pesquera, Estefanía, Jorge-Monjas, Pablo, Bustamante-Munguira, Juan, Álvarez, F. Javier, Resino, Salvador, Tamayo, Eduardo, and Heredia-Rodríguez, María

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-5-joh-10.1177_00207314211012357 for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study by Christian Ortega-Loubon, Gema Ruiz López del Prado, María F. Muñoz-Moreno, Esther Gómez-Sánchez, Rocío López-Herrero, Belén Sánchez-Quirós, Mario Lorenzo-Lopez, Estefanía Gómez-Pesquera, Pablo Jorge-Monjas, Juan Bustamante-Munguira, F. Javier Álvarez, Salvador Resino, Eduardo Tamayo and María Heredia-Rodríguez in International Journal of Health Services

Published
2022
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132. sj-docx-1-joh-10.1177_00207314211012357 - Supplemental material for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study

Author

Ortega-Loubon, Christian, Ruiz López del Prado, Gema, Muñoz-Moreno, María F., Gómez-Sánchez, Esther, López-Herrero, Rocío, Sánchez-Quirós, Belén, Lorenzo-Lopez, Mario, Gómez-Pesquera, Estefanía, Jorge-Monjas, Pablo, Bustamante-Munguira, Juan, Álvarez, F. Javier, Resino, Salvador, Tamayo, Eduardo, and Heredia-Rodríguez, María

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-joh-10.1177_00207314211012357 for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study by Christian Ortega-Loubon, Gema Ruiz López del Prado, María F. Muñoz-Moreno, Esther Gómez-Sánchez, Rocío López-Herrero, Belén Sánchez-Quirós, Mario Lorenzo-Lopez, Estefanía Gómez-Pesquera, Pablo Jorge-Monjas, Juan Bustamante-Munguira, F. Javier Álvarez, Salvador Resino, Eduardo Tamayo and María Heredia-Rodríguez in International Journal of Health Services

Published
2022
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133. sj-docx-7-joh-10.1177_00207314211012357 - Supplemental material for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study

Author

Ortega-Loubon, Christian, Ruiz López del Prado, Gema, Muñoz-Moreno, María F., Gómez-Sánchez, Esther, López-Herrero, Rocío, Sánchez-Quirós, Belén, Lorenzo-Lopez, Mario, Gómez-Pesquera, Estefanía, Jorge-Monjas, Pablo, Bustamante-Munguira, Juan, Álvarez, F. Javier, Resino, Salvador, Tamayo, Eduardo, and Heredia-Rodríguez, María

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-7-joh-10.1177_00207314211012357 for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study by Christian Ortega-Loubon, Gema Ruiz López del Prado, María F. Muñoz-Moreno, Esther Gómez-Sánchez, Rocío López-Herrero, Belén Sánchez-Quirós, Mario Lorenzo-Lopez, Estefanía Gómez-Pesquera, Pablo Jorge-Monjas, Juan Bustamante-Munguira, F. Javier Álvarez, Salvador Resino, Eduardo Tamayo and María Heredia-Rodríguez in International Journal of Health Services

Published
2022
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136. Antibody levels to SARS‐CoV‐2 spike protein in mothers and children from delivery to six months later.

Author

Martin‐Vicente, María, Carrasco, Itziar, Muñoz‐Gomez, María José, Lobo, Alicia Hernanz, Mas, Vicente, Vigil‐Vázquez, Sara, Vázquez, Mónica, Manzanares, Angela, Cano, Olga, Alonso, Roberto, Sepúlveda‐Crespo, Daniel, Tarancón‐Díez, Laura, Muñoz‐Fernández, María Ángeles, Muñoz‐Chapuli, Mar, Resino, Salvador, Navarro, Maria Luisa, and Martinez, Isidoro

Subjects
IMMUNOGLOBULIN analysis, CHILDBIRTH, CLINICAL pathology, STATISTICS, IMMUNIZATION, COVID-19, CORONAVIRUS spike protein, BREAST milk, APPLICATION software, WOMEN, VOLUMETRIC analysis, BLOOD collection, MANN Whitney U Test, IMMUNOASSAY, PEARSON correlation (Statistics), PUERPERIUM, DESCRIPTIVE statistics, COLLECTION & preservation of biological specimens, POLYMERASE chain reaction, DATA analysis software, DATA analysis, LONGITUDINAL method, WORLD Wide Web
Abstract

Introduction: Pregnant women are vulnerable to severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) infection. Neutralizing antibodies against the SARS‐CoV‐2 spike (S) protein protect from severe disease. This study analyzes the antibody titers to SARS‐CoV‐2 S protein in pregnant women and their newborns at delivery, and six months later. Methods: We conducted a prospective study on pregnant women with confirmed SARS‐CoV‐2 infection and newborns. Antibody (IgG, IgM, and IgA) titers were determined using immunoassays in serum and milk samples. An angiotensin‐converting enzyme 2 (ACE2) receptor‐binding inhibition assay to the S protein was performed on the same serum and milk samples. Results: At birth, antibodies to SARS‐CoV‐2 spike protein were detected in 81.9% of mothers' sera, 78.9% of cord blood samples, and 63.2% of milk samples. Symptomatic women had higher antibody titers (IgG, IgM, and IgA) than the asymptomatic ones (P < 0.05). At six months postpartum, IgG levels decreased drastically in children's serum (P < 0.001) but remained high in mothers' serum. Antibody titers correlated positively with its capacity to inhibit the ACE2–spike protein interaction at baseline in maternal sera (R2 = 0.203; P < 0.001), cord sera (R2 = 0.378; P < 0.001), and milk (R2 = 0.564; P < 0.001), and at six months in maternal sera (R2 = 0.600; P < 0.001). Conclusions: High antibody levels against SARS‐CoV‐2 spike protein were found in most pregnant women. Due to the efficient transfer of IgG to cord blood and high IgA titers in breast milk, neonates may be passively immunized to SARS‐CoV‐2 infection. Our findings could guide newborn management and maternal vaccination policies. [ABSTRACT FROM AUTHOR]

Published
2023
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137. Hepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia: A Case-Control Study.

Author

Pérez-García, Felipe, Vázquez-Morón, Sonia, Burgueño-García, Iván, Muñoz-Gómez, María José, Zea-Sevilla, María Ascensión, Calero, Miguel, Martínez, Isidoro, Rábano, Alberto, and Resino, Salvador

Subjects
HEPATITIS E virus, OLDER people, NEURODEGENERATION, CASE-control method, SEROPREVALENCE
Abstract

In this case-control study, we evaluated the association between serum antibodies against hepatitis E virus (HEV) and central nervous system (CNS) neurodegenerative disorders (NDs) in older people with dementia. The presence of anti-HEV antibodies was related to a higher adjusted odds ratio (aOR) of having CNS NDs by neuropathological diagnosis (aOR, 2.13; P =.007) and clinical/neuropathological diagnosis (1.84; P =.02). Besides, serum anti-HEV antibodies were directly related to neuropathological injury (higher vascular pathology [aOR, 1.97; P =.006]) and higher probability of Alzheimer-type pathology (1.84; P =.02). In conclusion, the presence of anti-HEV antibodies was related to higher odds of CNS NDs and neuropathological injury in older people. [ABSTRACT FROM AUTHOR]

Published
2023
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138. IL7RA rs6897932 Polymorphism Is Associated with Better CD4+ T-Cell Recovery in HIV Infected Patients Starting Combination Antiretroviral Therapy

Author

Resino, Salvador, Navarrete-Munoz, Maria A., Blanco, Julia, Pacheco, Yolanda M., Castro, Ivan, Berenguer, Juan, Santos, Jesus, Vera-Mendez, Francisco J., Gorgolas, Miguel, Angeles Jimenez-Sousa, M. A., Benito, Jose M., Rallon, Norma, Moreno, Santiago, Jarrin, Inma, Dalmau, David, Luisa Navarro, Maria, Isabel Gonzalez, Maria, Luis Blanco, Jose, Garcia, Federico, Rubio, Rafael, Antonio Iribarren, Jose, Gutierrez, Felix, Vidal, Francesc, Gonzalez, Juan, Alejos, Belen, Hernando, Victoria, Moreno, Cristina, Iniesta, Carlos, Garcia Sousa, Luis Miguel, Sanz Perez, Nieves, Angeles Munoz-Fernandez, M., Maria Garcia-Merino, Isabel, Consuegra Fernandez, Irene, Gomez Rico, Coral, Gallego de la Fuente, Jorge, Palau Concejo, Paula, Portilla, Joaquin, Merino, Esperanza, Reus, Sergio, Boix, Vicente, Giner, Livia, Gadea, Carmen, Portilla, Irene, Pampliega, Maria, Diez, Marcos, Carlos Rodriguez, Juan, Sanchez-Paya, Jose, Luis Gomez, Juan, Hernandez, Jehovana, Remedios Aleman, Maria, del Mar Alonso, Maria, Inmaculada Hernandez, Maria, Diaz-Flores, Felicitas, Garcia, Dacil, Pelazas, Ricardo, Lopez Lirola, Ana, Sanz Moreno, Jose, Arranz Caso, Alberto, Hernandez Gutierrez, Cristina, Novella Mena, Maria, Pulido, Federico, Bisbal, Otilia, Hernando, Asuncion, Dominguez, Lourdes, Crestelo, David Rial, Bermejo, Laura, Santacreu, Mireia, Arrizabalaga, Julio, Jose Aramburu, Maria, Camino, Xabier, Rodriguez-Arrondo, Francisco, Angel von Wichmann, Miguel, Pascual Tome, Lidia, Angel Goenaga, Miguel, Bustinduy, Ma Jesus, Azkune, Harkaitz, Ibarguren, Maialen, Lizardi, Aitziber, Kortajarena, Xabier, Masia, Mar, Padilla, Sergio, Navarro, Andres, Montolio, Fernando, Robledano, Catalina, Gregori Colome, Joan, Adsuar, Araceli, Pascual, Rafael, Fernandez, Marta, Garcia, Elena, Alberto Garcia, Jose, Barber, Xavier, Lopez Bernaldo de Quiros, Juan Carlos, Gutierrez, Isabel, Ramirez, Margarita, Padilla, Belen, Gijon, Paloma, Aldamiz-Echevarria, Teresa, Tejerina, Francisco, Jose Parras, Francisco, Balsalobre, Pascual, Diez, Cristina, Perez Latorre, Leire, Peraire, Joaquin, Vilades, Consuelo, Veloso, Sergio, Vargas, Montserrat, Lopez-Dupla, Miguel, Olona, Montserrat, Rull, Anna, Rodriguez-Gallego, Esther, Alba, Veronica, Montero Alonso, Marta, Lopez Aldeguer, Jose, Blanes Julia, Marino, Tasias Pitarch, Maria, Castro Hernandez, Ivan, Calabuig Munoz, Eva, Cuellar Tovar, Sandra, Salavert Lleti, Miguel, Fernandez Navarro, Juan, Gonzalez-garcia, Juan, Arnalich, Francisco, Ramon Arribas, Jose, Bernardino de la Serna, Jose Ignacio, Miguel Castro, Juan, Escosa, Luis, Herranz, Pedro, Hontanon, Victor, Garcia-Bujalance, Silvia, Garcia Lopez-Hortelano, Milagros, Gonzalez-Baeza, Alicia, Luz Martin-Carbonero, Maria, Mayoral, Mario, Jose Mellado, Maria, Esteban Mican, Rafael, Montejano, Rocio, Luisa Montes, Maria, Moreno, Victoria, Perez-Valero, Ignacio, Rodes, Berta, Sainz, Talia, Sendagorta, Elena, Stella Alcariz, Natalia, Valencia, Eulalia, Ramon Blanco, Jose, Antonio Oteo, Jose, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Perez-Martinez, Laura, Jaen, Angels, Sanmarti, Montse, Cairo, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemi, Rivero, Maria, Reparaz, Jesus, Ruiz de Alda, Maria Gracia, de Leon Cano, Maria Teresa, Ruiz de Galarreta, Beatriz Pierola, Segura, Ferran, Jose Amengual, Maria, Navarro, Gemma, Sala, Montserrat, Cervantes, Manuel, Pineda, Valentin, Calzado, Sonia, Navarro, Marta, de los Santos, Ignacio, Sanz Sanz, Jesus, Salas Aparicio, Ana, Sarria Cepeda, Cristina, Garcia-Fraile Fraile, Lucio, Martin Gayo, Enrique, Luis Casado, Jose, Dronda, Fernando, Moreno, Ana, Perez Elias, Maria Jesus, Gomez Ayerbe, Cristina, Gutierrez, Carolina, Madrid, Nadia, del Campo Terron, Santos, Marti, Paloma, Ansa, Uxua, Serrano, Sergio, Jesus Vivancos, Maria, Bernal, Enrique, Cano, Alfredo, Alcaraz Garcia, Antonia, Bravo Urbieta, Joaquin, Munoz, Angeles, Jose Alcaraz, Maria, del Carmen Villalba, Maria, Hernandez, Jose, Pena, Alejandro, Munoz, Leopoldo, Casas, Paz, Alvarez, Marta, Chueca, Natalia, Vinuesa, David, Martinez-Montes, Clara, Del Romero, Jorge, Rodriguez, Carmen, Puerta, Teresa, Carlos Carrio, Juan, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Riera, Melchor, Penaranda, Maria, Leyes, Maria, Ribas, Ma Angels, Campins, Antoni A., Vidal, Carmen, Fanjul, Francisco, Murillas, Javier, Homar, Francisco, Gomez Ayerbe, Crisitina, Viciana, Isabel, Palacios, Rosario, Maria Gonzalez, Carmen, Viciana, Pompeyo, Espinosa, Nuria, Fernando Lopez-Cortes, Luis, Podzamczer, Daniel, Ferrer, Elena, Imaz, Arkaitz, Tiraboschi, Juan, Silva, Ana, Saumoy, Maria, Olalla, Julian, del Arco, Alfonso, de la Torre, Javier, Luis Prada, Jose, de Lomas Guerrero, Jose Maria Garcia, Perez Stachowski, Javier, Juan Martinez, Onofre, Jesus Vera, Francisco, Martinez, Lorena, Garcia, Josefina, Alcaraz, Begona, Jimeno, Amaya, Castro Iglesias, Angeles, Pernas Souto, Berta, Mena de Cea, Alvaro, Galera, Carlos, Albendin, Helena, Perez, Aurora, Iborra, Asuncion, Moreno, Antonio, Merlos, Maria Angustias, Vidal, Asuncion, Suarez-Garcia, Ines, Malmierca, Eduardo, Gonzalez-Ruano, Patricia, Martin Rodrigo, Dolores, Ruiz Seco, Ma Pilar, Omar Mohamed-Balghata, Mohamed, Gomez Vidal, Maria Amparo, Estrada Perez, Vicente, Tellez Molina, Maria Jesus, Vergas Garcia, Jorge, Perez-Somarriba Moreno, Juncal, Cabello, Alfonso, Alvarez, Beatriz, Prieto, Laura, Galindo Puerto, Maria Jose, Fernando Vilalta, Ramon, Ferrer Ribera, Ana, Rivero Roman, Antonio, Brieva Herrero, Maria Teresa, Rivero Juarez, Antonio, Lopez Lopez, Pedro, Machuca Sanchez, Isabel, Pena Martinez, Jose, Cervero Jimenez, Miguel, Torres Perea, Rafael, Jusdado Ruiz-Capillas, Juan Jose, Pineda, Juan A., CoRIS HIV Biobank Integrated Spani, Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), European Commission, Resino, Salvador, Castro, Iván, Resino, Salvador [0000-0001-8783-0450], and Castro, Iván [0000-0001-9938-2122]

Subjects
Male, 0301 basic medicine, humanos, lcsh:QR1-502, HIV Infections, Biochemistry, Gastroenterology, lcsh:Microbiology, 0302 clinical medicine, Receptor subunit, Genotype, Hiv infected patients, Drug Interactions, 030212 general & internal medicine, mediana edad, Cd4 t cell, Brief Report, immune reconstitution, Middle Aged, adulto, IL7RA, antirretrovirales, interacciones farmacológicas, Anti-Retroviral Agents, Female, SNPs, Adult, Cart, medicine.medical_specialty, Single-nucleotide polymorphism, cART, Polymorphism, Single Nucleotide, 03 medical and health sciences, Internal medicine, Statistical significance, medicine, Humans, Molecular Biology, Receptors, Interleukin-7, business.industry, HIV, Antiretroviral therapy, CD4, CD4 Lymphocyte Count, recuento de linfocitos CD4, 030104 developmental biology, infecciones por VIH, genotipo, business
Abstract

This article belongs to the Section Molecular Medicine., Interleukin-7 receptor subunit alpha (IL7RA) rs6897932 polymorphism IS related to CD4+ recovery after combination antiretroviral therapy (cART), but no studies so far have analyzed its potential impact in patients with very low CD4+ T-cells count. We aimed to analyze the association between IL7RA rs6897932 polymorphism and CD4+ T-cells count restoration in HIV-infected patients starting combination antiretroviral therapy (cART) with CD4+ T-cells count 20% and was in Hardy–Weinberg equilibrium (p = 0.550). Of 411 patients, 256 carried the CC genotype, while 155 had the CT/TT genotype. The CT/TT genotype was associated with a higher slope of CD4+ T-cells recovery (arithmetic mean ratio; AMR = 1.16; p = 0.016), higher CD4+ T-cells increase (AMR = 1.19; p = 0.004), and higher CD4+ T-cells count at the end of follow-up (AMR = 1.13; p = 0.006). Besides, rs6897932 CT/TT was related to a higher odds of having a value of CD4+ T-cells at the end of follow-up ≥500 CD4+ cells/mm3 (OR = 2.44; p = 0.006). After multiple testing correction (Benjamini–Hochberg), only the increase of ≥ 400 CD4+ cells/mm3 lost statistical significance (p = 0.052). IL7RA rs6897932 CT/TT genotype was related to a better CD4+ T-cells recovery and it could be used to improve the management of HIV-infected patients starting cART with CD4+ T-cells count, This study has been (partially) funded by grants RD12/0017/0031 and D16/0025/0013 to JMB, and RD12/0017/0024 and RD16CIII/0002/0002 to SR as part of the Health Research and Development Strategy, State Plan for Scientific and Technical Research and Innovation (2008–2011; 2013–2016) and co-financed by Institute of Health Carlos III, ISCIII—Sub-Directorate General for Research Assessment and Promotion and European Regional Development Fund (ERDF). MA Jiménez-Sousa is funded by project RD16CIII/0002/0002; MA Navarrete-Muñoz is co-funded by RD16/0025/0013 project and Intramural Research Scholarship from IIS-FJD. N Rallón is a Miguel Servet investigator from the ISCIII [grant number CP14/00198].

Published
2019

139. Misdiagnosis rate of among negative COVID-19 patients in real-life with Panbio COVID-19 Antigen Rapid Test during 2021

Author

Ryan, Pablo, primary, Pérez-García, Felipe, additional, Torres-Macho, Juan, additional, Bibiano, Carlos, additional, Ignacio Lazo, Juan, additional, Castaño-Ochoa, Guillermo, additional, Vidal-Alcántara, Erick Joan, additional, Muñoz-Gómez, María José, additional, Martínez, Isidoro, additional, and Resino, Salvador, additional

Published
2022
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140. Plasma miRNA profile at COVID-19 onset predicts severity status and mortality

Author

Fernández-Pato, Asier, primary, Virseda-Berdices, Ana, additional, Resino, Salvador, additional, Ryan, Pablo, additional, Martínez-González, Oscar, additional, Pérez-García, Felipe, additional, Martin-Vicente, María, additional, Valle-Millares, Daniel, additional, Brochado-Kith, Oscar, additional, Blancas, Rafael, additional, Martínez, Amalia, additional, Ceballos, Francisco C., additional, Bartolome-Sánchez, Sofía, additional, Vidal-Alcántara, Erick Joan, additional, Alonso, David, additional, Blanca-López, Natalia, additional, Ramirez Martinez-Acitores, Ignacio, additional, Martin-Pedraza, Laura, additional, Jiménez-Sousa, María Ángeles, additional, and Fernández-Rodríguez, Amanda, additional

Published
2022
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141. Reply to Pati et al

Author

Pérez-García, Felipe, primary, Martin-Vicente, María, additional, Bermejo-Martin, Jesús F, additional, Resino, Salvador, additional, and Martínez, Isidoro, additional

Published
2022
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142. DBP rs7041 and DHCR7 rs3829251 are Linked to CD4+ Recovery in HIV Patients on Antiretroviral Therapy

Author

Resino, Salvador, primary, Jiménez-Sousa, María Ángeles, additional, Blanco, Julià, additional, Pacheco, Yolanda M., additional, del Romero, Jorge, additional, Peraire, Joaquim, additional, Virseda-Berdices, Ana, additional, Muñoz-Gómez, María José, additional, Galera-Peñaranda, Carlos, additional, García-Fraile, Lucio Jesus, additional, Benito, José M., additional, and Rallón, Norma, additional

Published
2022
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144. Role of Viral Storm in Critical COVID-19 Illness: A Prospective Cohort Multicentric Study

Author

Bermejo-Martin, Jesus F., primary, García Mateo, Nadia, additional, Motos, Anna, additional, Resino, Salvador, additional, Tamayo, Luis, additional, Ryan, Pablo, additional, Bustamante-Munguira, Elena, additional, Gallego Curto, Elena, additional, Úbeda-Iglesias, Alejandro, additional, de la Torre, María del Carmen, additional, Estella, Angel, additional, Campos-Fernández, Sandra, additional, Martínez Varela, Ignacio, additional, Pérez-García, Felipe, additional, Socias, Lorenzo, additional, Messa, Juan López, additional, Vidal-Cortés, Pablo, additional, Sagredo Meneses, Víctor, additional, González-Rivera, Milagros, additional, Carbonell, Nieves, additional, de Gonzalo-Calvo, David, additional, Martín Delgado, María Cruz, additional, Valdivia, Luis Jorge, additional, Martín-López, Caridad, additional, Jorge García, Ruth Noemí, additional, Maseda, Emilio, additional, Loza-Vázquez, Ana, additional, kelvin, david, additional, Barbé, Ferran, additional, Torres, Antoni, additional, and Group, CIBERES-UCI-COVID, additional

Published
2022
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145. HCV eradication with DAAs differently affects HIV males and females: A whole miRNA sequencing characterization

Author

Valle-Millares, Daniel, primary, Brochado-Kith, Óscar, additional, Gómez-Sanz, Alicia, additional, Martín-Carbonero, Luz, additional, Ryan, Pablo, additional, De los Santos, Ignacio, additional, Castro, Juan M., additional, Troya, Jesús, additional, Mayoral-Muñoz, Mario, additional, Cuevas, Guillermo, additional, Martínez-Román, Paula, additional, Sanz-Sanz, Jesús, additional, Muñoz-Muñoz, María, additional, Jiménez-Sousa, María Á, additional, Resino, Salvador, additional, Briz, Verónica, additional, and Fernández-Rodríguez, Amanda, additional

Published
2022
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149. Obesity-Related Single-Nucleotide Polymorphisms and Weight Gain Following First-Line Antiretroviral Therapy.

Author

Berenguer, Juan, Jarrín, Inmaculada, Bellón, José M, Díez, Cristina, Jiménez-Sousa, María A, Roca, Cristina, González-García, Juan, Dalmau, David, Olalla, Julián, Herrero, Carmen, Villarroya, Francesc, Domingo, Pere, and Resino, Salvador

Subjects
OBESITY complications, WEIGHT gain risk factors, HIV-positive persons, CONFIDENCE intervals, GENETICS, SINGLE nucleotide polymorphisms, HIGHLY active antiretroviral therapy, RISK assessment, GENOTYPES, DESCRIPTIVE statistics, RESEARCH funding, BODY mass index
Abstract

Background We studied the association of obesity-related single-nucleotide polymorphisms (OR-SNPs) with weight gain after antiretroviral therapy (ART) in people with human immunodeficiency virus (HIV; PWH). Methods Participants were ART-naive PWH from the Spanish HIV Research Cohort who started ART from 2014 onward and had blood/DNA deposited in the cohort Biobank. The primary outcome was change in weight at 96 weeks after starting ART. We genotyped 14 OR-SNPs from a meta-analysis of genome-wide association studies of body mass index (BMI) loci. Changes over time in weight and BMI were studied using adjusted linear mixed models. Results A total of 1021 PWH were included. The mean weight gain over 96 weeks was 2.90 (95% confidence interval, 2.54–3.26) kg. Factors associated with higher weight gain were female sex, birth in sub-Saharan Africa, prior AIDS, CD4+ <200 cells/µL, HIV-RNA >100 000 copies/mL, negative hepatitis C virus serology, and use of tenofovir alafenamide. A significant association was found between ZC3H4 rs3810291 GG genotype and BCDIN3D/FAIM2 rs7138803 GG genotype polymorphisms and weight and BMI increase. The estimated adjusted mean (standard error [SE]) of weight gain was 4.26 (0.56) kg in ZC3H4 rs3810291 GG carriers and 2.66 (0.19) kg in AA/AG carriers (P =.007). Likewise the estimated weight gain at 96 weeks was 3.35 (0.29) kg in BCDIN3D/FAIM2 rs7138803 GG carriers and 2.51 (0.24) kg in AG/AA carriers (P =.020). Conclusions Genetic factors may play a role in weight gain after ART initiation. Further work is needed to replicate our findings and understand how the identified SNPs lead to higher weight gain in this context. [ABSTRACT FROM AUTHOR]

Published
2023
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150. Relative telomere length impact on mortality of COVID‐19: Sex differences.

Author

Virseda‐Berdices, Ana, Concostrina‐Martinez, Leyre, Martínez‐González, Oscar, Blancas, Rafael, Resino, Salvador, Ryan, Pablo, Martin‐Vicente, María, Brochado‐Kith, Oscar, Blanca‐López, Natalia, Mallol Poyato, María J., López Matamala, Blanca, Martín Parra, Carmen, Jiménez‐Sousa, María Á, and Fernández‐Rodríguez, Amanda

Subjects
TELOMERES, COVID-19, MORTALITY, DEATH rate, CONFIDENCE intervals
Abstract

Increasing age is associated with severity and higher mortality of COVID‐19. Telomere shortening is associated with higher risk of infections and may be used to identify those patients who are more likely to die. We evaluated the association between relative telomere length (RTL) and COVID‐19 mortality. RTL was measured in patients hospitalized because of COVID‐19. We used Kaplan–Meier method to analyze survival probabilities, and Cox regression to investigate the association between RTL and mortality (30 and 90 days). Six hundred and eight patients were included in the analysis (mean age =72.5 years, 41.1% women, and 53.8% Caucasic). During the study period, 75 people died from COVID‐19 and 533 survived. Lower RTL was associated with a higher risk of death in women either at 30 (adjusted hazard ratio [HR] (aHR) = 3.33; 95% confidence interval [CI] = 1.05–10.00; p = 0.040) and at 90 days (aHR = 3.57; 95%CI = 1.23–11.11; p = 0.019). Lower RTL was associated with a higher risk of dying of COVID‐19 in women. This finding suggests that RTL has an essential role in the prognosis of this subset of the population. [ABSTRACT FROM AUTHOR]

Published
2023
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