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377 results on '"Rosing, Douglas R."'

101. Inducible polymorphic ventricular tachycardia and ventricular fibrillation in a subgroup of patients with hypertrophic cardiomyopathy at high risk for sudden death

Author

Watson, Rita M., Schwartz, Janine Liberati, Maron, Barry J., Tucker, Eben, Rosing, Douglas R., and Josephson, Mark E.

Abstract

This investigation was undertaken to elucidate the underlying electrophysiologic substrate in hypertrophic cardiomyopathy and to identify possible predictors of sudden death in this patient population. Programmed stimulation was performed in 18 patients aged 14 to 64 years (mean 36) believed to be at high risk for sudden death on the basis of prior cardiac arrest or syncope, nonsustained ventricular tachycardia on Holter ambulatory electrocardiographic (ECG) monitoring or a family history of frequent sudden death.

Published
1987
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102. Differences in coronary flow and myocardial metabolism at rest and during pacing between patients with obstructive and patients with nonobstructive hypertrophic cardiomyopathy

Author

Cannon, Richard O., Schenke, William H., Maron, Barry J., Tracy, Cynthia M., Leon, Martin B., Brush, John E., Rosing, Douglas R., and Epstein, Stephen E.

Abstract

Fifty patients with hypertrophic cardiomyopathy underwent invasive study of coronary and myocardial hemodynamics in the basal state and during the stress of pacing. The 23 patients with basal obstruction (average left ventricular outflow gradient, 77 ± 33 mm Hg; left ventricular systolic pressure, 196 ± 33 mm Hg, mean ± 1 SD) had significantly lower coronary resistance (0.85 ± 0.18 versus 1.32 ± 0.44 mm Hg min/ml, p < 0.001) and higher basal coronary flow (106 ± 20 versus 80 ± 25 ml/min, p < 0.001) in the anterior left ventricle, associated with higher regional myocardial oxygen consumption (12.4 ± 3.6 versus 8.9 ± 3.3 ml oxygen/min, p < 0.001) compared with the 27 patients without obstruction (mean left ventricular systolic pressure 134 ± 18 mm Hg, p < 0.001).

Published
1987
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103. Three year anatomic, functional and clinical follow-up after successful percutaneous transluminal coronary angioplasty

Author

Rosing, Douglas R., Cannon, Richard O., Watson, Rita M., Bonow, Robert O., Mincemoyer, Rita, Ewels, Carolyn, Leon, Martin B., Lakatos, Edward, Epstein, Stephen E., and Kent, Kenneth M.

Abstract

Because the long-term anatomic effects of percutaneous transluminal coronary angioplasty are unknown, follow-up evaluations including coronary angiography, treadmill exercise testing and rest and bicycle exercise radionuclide angiography were performed in 46 patients 6.3 ± 2.0 and 37.6 ± 3.6 (mean ± SD) months after they had undergone successful single lesion angioplasty. The severity of the coronary stenosis decreased significantly at each evaluation; the mean diameter stenosis was 66 ± 13% before angioplasty, 30 ± 13% immediately after and 26 ± 16% and 19 ± 13% at 6 months and 3 years, respectively. Exercise time increased from 9.8 ± 4.4 minutes before angioplasty to 18.3 ± 4.5 minutes immediately after the procedure and remained at that level at 6 months (20.3 ± 4.6 minutes) and 3 years (18.2 ± 4.5 minutes).

Published
1987
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105. Dynamic subaortic obstruction in hypertrophic cardiomyopathy: Analysis by pulsed doppler echocardiography

Author

Maron, Barry J., Gottdiener, John S., Arce, Javier, Rosing, Douglas R., Wesley, Yvonne E., and Epstein, Stephen E.

Abstract

To determine whether true obstruction to left ventricular ejection exists in patients with hypertrophic cardiomyopathy and a subaortic gradient, pulsed Doppler echocardiography was used to analyze the patterns of left ventricular emptying in 50 patients with hypertrophic cardiomyopathy (20 with and 30 without evidence of obstruction) and in 20 normal subjects. In obstructive hypertrophic cardiomyopathy, left ventricular ejection was characterized by early and rapid emptying (76 ± 14% of aortic flow velocity in the initial one-third of systole). The proportion of forward flow velocity occurring before initial mitral-septal contact (and hence, by inference before the onset of the subaortic gradient) was variable, but averaged 58%. In contrast, the proportion of forward flow velocity occurring after mitral-septal contact (and, therefore, concomitant with the gradient and increased intraventricular pressure) was considerable, averaging over 40%.

Published
1985
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106. Isovolumic relaxation period in hypertrophic cardiomyopathy: Assessment by radionuclide angiography

Author

Betocchi, Sandro, Bonow, Robert O., Bacharach, Stephen L., Rosing, Douglas R., Maron, Barry J., and Green, Michael V.

Abstract

Left ventricular isovolumic relaxation and the relation between relaxation and filling were studied in 90 patients with hypertrophic cardiomyopathy and 29 control subjects using radionuclide angiography. The isovolumic relaxation period was determined automatically on left ventricular time-activity curves as the interval between minimal volume and onset of rapid filling. In 17 patients, M-mode echocardiography performed simultaneously with radionuclide angiography demonstrated that onset of mitral valve opening correlated well with onset of rapid filling (r = 0.84, p < 0.001).

Published
1986
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107. Angina caused by reduced vasodilator reserve of the small coronary arteries

Author

Cannon, Richard O., Watson, Rita M., Rosing, Douglas R., and Epstein, Stephen E.

Abstract

To study the mechanism of chest pain in patients vvith insignificant large vessel coronary artery disease, 22 patients underwent great cardiac vein flow, coronary resistance and lactate determinations at rest and with coronary sinus pacing followed by coronary arteriography. Nine patients experiencing chest pain with pacing demonstrated significantly lesser increase in flow from base-line values (45 ± 30versus86 ± 50% [mean ± standard deviation], p < 0.025), lesser decrease from baseline in resistance (-28 ± 18 versus -44 ± 11%, p < 0.001) and less lactate consumption (25.0 ± 23.6 versus 45.6 ± 19.0 mmol ml/min, p < 0.025) compared with the 13 patients without pacing-induced chest pain. Pacing conducted during the cold pressor test elicited similar abnormalities in those patients experiencing chest pain and those who did not: four of eight patients experiencing chest pain demonstrated a lowered or new anginal threshold compared with that of the control pacing study. Coronary arteriography during the cold pressor test revealed no significant change in epicardial coronary artery dimension.

Published
1983
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110. Effects of heterogeneous myocardial perfusion on coronary venous H2 desaturation curves and calculations of coronary flow

Author

Klocke, Francis J., Koberstein, Robert C., Pittman, David E., Bunnell, Ivan L., Greene, David G., Rosing, Douglas R., Klocke, Francis J., Koberstein, Robert C., Pittman, David E., Bunnell, Ivan L., Greene, David G., and Rosing, Douglas R.

Abstract

The present investigation was intended to evaluate myocardial inert gas desaturation curves for manifestations of heterogeneous coronary perfusion. The test gas was hydrogen (H2) and blood H2 analyses were performed with a gas chromatograph capable of detecting small but prolonged venous-arterial H2 differences produced by areas of reduced flow. Curves were initially obtained after 4-min left ventricular infusions of H2-saturated saline in six patients with arteriographically proven coronary artery disease, three patients with normal coronary arteries, and nine closed-chest dogs. The dogs were studied before and after embolic occlusion of a portion of the left coronary artery. Although the slopes of their semilogarithmically plotted venous desaturation curves varied with time before embolization, they showed more distinct deviations from single exponentials after embolization (after H2 concentrations had fallen below 15% of their initial values). The human curves divided similarly, those from coronary artery patients deviating appreciably from single exponentials. A similar separation was also evident in studies of coronary venous-arterial H2 differences after 20 min of breathing 2% H2: data were obtained in four dogs before and after coronary embolization, and in three normal patients, and five patients with coronary artery disease. Additional data indicated that the findings were not the result of right atrial admixture in sampled coronary venous blood, although admixture occurred frequently when blood was sampled in the first 2 cm of the coronary sinus (as seen in the frontal projection). Finally, average coronary flows calculated from a given set of data varied significantly with different methods of calculation. Areas of below-average flow seemed likely to be overlooked when single rate constants of desaturation, relatively insensitive analytical techniques, or relatively short periods of saturation and (or) desaturation are employed.

Published
1968

114. Natural history of left ventricular function during 1 year after acute myocardial infarction: Comparison with clinical, electrocardiographic and biochemical determinations

Author

Borer, Jeffrey S., primary, Rosing, Douglas R., additional, Miller, Ronald H., additional, Stark, Robert M., additional, Kent, Kenneth M., additional, Bacharach, Stephen L., additional, Green, Michael V., additional, Lake, Charles R., additional, Cohen, Howard, additional, Holmes, David, additional, Donohue, Dennis, additional, Baker, William, additional, and Epstein, Stephen E., additional

Published
1980
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118. Exercise-induced left ventricular dysfunction in symptomatic and asymptomatic patients with aortic regurgitation: Assessment with radionuclide cineangiography

Author

Borer, Jeffrey S., primary, Bacharach, Stephen L., additional, Green, Michael V., additional, Kent, Kenneth M., additional, Henry, Walter L., additional, Rosing, Douglas R., additional, Seides, Stuart F., additional, Johnston, Gerald S., additional, and Epstein, Stephen E., additional

Published
1978
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141. Reply

Author

Epstein, Stephen E., primary, Kent, Kenneth M., additional, Goldstein, Robert E., additional, Borer, Jeffrey S., additional, and Rosing, Douglas R., additional

Published
1980
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