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524 results on '"Routy, Bertrand"'

101. Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in advanced non-small cell lung cancer patients

Author

Derosa, Lisa, Routy, Bertrand, Thomas, Andrew Maltez, Iebba, Valerio, Zalcman, Gerard, Friard, Sylvie, Mazieres, Julien, Audigier-Valette, Clarisse, Moro-Sibilot, Denis, Goldwasser, François, Silva, Carolina Alves Costa, Terrisse, Safae, Bonvalet, Melodie, Scherpereel, Arnaud, Pegliasco, Hervé, Richard, Corentin, Ghiringhelli, François, Elkrief, Arielle, Desilets, Antoine, Blanc-Durand, Felix, Cumbo, Fabio, Blanco, Aitor, Boidot, Romain, Chevrier, Sandy, Daillère, Romain, Kroemer, Guido, Alla, Laurie, Pons, Nicolas, Chatelier, Emmanuelle Le, Galleron, Nathalie, Roume, Hugo, Dubuisson, Agathe, Bouchard, Nicole, Messaoudene, Meriem, Drubay, Damien, Deutsch, Eric, Barlesi, Fabrice, Planchard, David, Segata, Nicola, Martinez, Stéphanie, Zitvogel, Laurence, Soria, Jean-Charles, and Besse, Benjamin

Subjects
Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Humans, Immunologic Factors, Akkermansia, Immunotherapy, Article
Abstract

Aside from PD-L1 expression, biomarkers of response to immune checkpoint inhibitors (ICI) in non-small cell lung cancer (NSCLC) are needed. We previously reported in 100 NSCLC and kidney cancer patients that fecal Akkermansia muciniphila (Akk) correlated with ICI clinical success. The endpoint of this study was to prospectively validate the prognostic significance of fecal Akk in advanced NSCLC patients treated with first or second line ICI. We performed shotgun metagenomics-based microbiome profiling using two different pipelines in 338 NSCLC patients. Baseline stool Akk was associated with increased objective response rates and overall survival in multivariate analyses, independent of PD-L1 expression, antibiotics and performance status. Intestinal Akk was accompanied by a richer commensalism, including Eubacterium hallii and Bifidobacterium adolescentis and a more inflamed tumor microenvironment in a subset of patients. However, antibiotic use (20% of cases) coincided with a relative dominance of Akk above 4.8% accompanied with the genus Clostridium, both associated with resistance to ICI. Our study shows significant differences in relative abundance of Akk that could be useful for future studies as a tool to aid patient stratification.

Published
2022

102. Characterization of Alistipes montrealensis sp. nov., Isolated from Human Feces of a Patient with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors

Author

Routy, Bertrand, primary, Richard, Corentin, additional, Benlaïfaoui, Myriam, additional, Lapierre, Simon Grandjean, additional, Armstrong, Nicholas, additional, Al-Saleh, Afnan, additional, Boko, Mélodie, additional, Jacq, Maxime, additional, Watson, Ian R., additional, Mihalcioiu, Catalin, additional, Elkrief, Arielle, additional, Tidjani Alou, Maryam, additional, Messaoudene, Meriem, additional, and Diop, Khoudia, additional

Published
2022
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103. MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

Author

Limagne, Emeric, primary, Nuttin, Lisa, additional, Thibaudin, Marion, additional, Jacquin, Elise, additional, Aucagne, Romain, additional, Bon, Marjorie, additional, Revy, Solène, additional, Barnestein, Robby, additional, Ballot, Elise, additional, Truntzer, Caroline, additional, Derangère, Valentin, additional, Fumet, Jean-David, additional, Latour, Charlène, additional, Rébé, Cédric, additional, Bellaye, Pierre-Simon, additional, Kaderbhaï, Coureche-Guillaume, additional, Spill, Aodrenn, additional, Collin, Bertrand, additional, Callanan, Mary B., additional, Lagrange, Aurélie, additional, Favier, Laure, additional, Coudert, Bruno, additional, Arnould, Laurent, additional, Ladoire, Sylvain, additional, Routy, Bertrand, additional, Joubert, Philippe, additional, and Ghiringhelli, François, additional

Published
2022
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104. A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota

Author

Messaoudene, Meriem, primary, Pidgeon, Reilly, additional, Richard, Corentin, additional, Ponce, Mayra, additional, Diop, Khoudia, additional, Benlaifaoui, Myriam, additional, Nolin-Lapalme, Alexis, additional, Cauchois, Florent, additional, Malo, Julie, additional, Belkaid, Wiam, additional, Isnard, Stephane, additional, Fradet, Yves, additional, Dridi, Lharbi, additional, Velin, Dominique, additional, Oster, Paul, additional, Raoult, Didier, additional, Ghiringhelli, François, additional, Boidot, Romain, additional, Chevrier, Sandy, additional, Kysela, David T., additional, Brun, Yves V., additional, Falcone, Emilia Liana, additional, Pilon, Geneviève, additional, Oñate, Florian Plaza, additional, Gitton-Quent, Oscar, additional, Le Chatelier, Emmanuelle, additional, Durand, Sylvere, additional, Kroemer, Guido, additional, Elkrief, Arielle, additional, Marette, André, additional, Castagner, Bastien, additional, and Routy, Bertrand, additional

Published
2022
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105. Camu Camu effects on microbial translocation and systemic immune activation in ART-treated people living with HIV: protocol of the single-arm non-randomised Camu Camu prebiotic pilot study (CIHR/CTN PT032)

Author

Isnard, Stéphane, primary, Fombuena, Brandon, additional, Ouyang, Jing, additional, Royston, Léna, additional, Lin, John, additional, Bu, Simeng, additional, Sheehan, Nancy, additional, Lakatos, Peter L, additional, Bessissow, Talat, additional, Chomont, Nicolas, additional, Klein, Marina, additional, Lebouché, Bertrand, additional, Costiniuk, Cecilia T, additional, Routy, Bertrand, additional, Marette, André, additional, and Routy, Jean-Pierre, additional

Published
2022
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106. Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis

Author

Yonekura, Satoru, primary, Terrisse, Safae, additional, Alves Costa Silva, Carolina, additional, Lafarge, Antoine, additional, Iebba, Valerio, additional, Ferrere, Gladys, additional, Goubet, Anne-Gaëlle, additional, Fahrner, Jean-Eudes, additional, Lahmar, Imran, additional, Ueda, Kousuke, additional, Mansouri, Gibrail, additional, Pizzato, Eugénie, additional, Ly, Pierre, additional, Mazzenga, Marine, additional, Thelemaque, Cassandra, additional, Fidelle, Marine, additional, Jaulin, Fanny, additional, Cartry, Jérôme, additional, Deloger, Marc, additional, Aglave, Marine, additional, Droin, Nathalie, additional, Opolon, Paule, additional, Puget, Angélique, additional, Mann, Fanny, additional, Neunlist, Michel, additional, Bessard, Anne, additional, Aymeric, Laetitia, additional, Matysiak-Budnik, Tamara, additional, Bosq, Jacques, additional, Hofman, Paul, additional, Duong, Connie P.M., additional, Ugolini, Sophie, additional, Quiniou, Valentin, additional, Berrard, Sylvie, additional, Ryffel, Bernhard, additional, Kepp, Oliver, additional, Kroemer, Guido, additional, Routy, Bertrand, additional, Lordello, Leonardo, additional, Bani, Mohamed-Amine, additional, Segata, Nicola, additional, Yengej, Fjodor Yousef, additional, Clevers, Hans, additional, Scoazec, Jean-Yves, additional, Pasolli, Edoardo, additional, Derosa, Lisa, additional, and Zitvogel, Laurence, additional

Published
2021
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107. Tractidigestivibacter montrealensis sp. nov., a new member of human gut microbiota isolated from a healthy volunteer.

Author

Benlaïfaoui, Myriam, Richard, Corentin, Diop, Awa, Naimi, Sabrine, Belkaid, Wiam, Bernet, Eve, Veyrier, Frederic, Elkrief, Arielle, Bobay, Louis-Marie, Routy, Bertrand, and Diop, Khoudia

Subjects
HUMAN microbiota, NUCLEIC acid hybridization, DENITRIFYING bacteria, VOLUNTEERS, VOLUNTEER service
Abstract

Strain KD21T, isolated from the fecal sample of a healthy female volunteer, is a strictly anaerobic, non-motile, Gram-staining-positive, saccharolytic small rod that does not produce spores. Strain KD21T was able to grow in the range of temperature 28°C–37°C (optimum, 37 °C), pH 6.0–8.0 (optimum, pH 7.0), and with 0–5.0 g/l NaCl (optimum, 0 g/l NaCl). Bacteria cells reduced nitrates to nitrites. Its major fatty acids were C18:1ω9c, C16:0, C18:0, and summed in feature 8 (C18:1ω7c and/or C18:1ω6c). 16S rRNA gene phylogenetic analysis revealed that KD21T is a member of the genus Tractidigestivibacter and is distinct from any species with validly published names. The sequence showed 98.48% similarity with T. scatoligenes SK9K4T. The DNA G + C content of strain KD21T was 62.6 mol%. The DNA–DNA hybridization and OrthoANI values between strain KD21T and T. scatoligenes SK9K4T were 40.2% and 90.2%, respectively. Differences in phenotypic, phylogenetic, chemotaxonomic, and genomic characteristics indicated that strain KD21T represents a novel species within the genus Tractidigestivibacter. The name T. montrealensis sp. nov. is proposed and the type strain is KD21T (= CSUR Q8103T =  DSM 115111T). [ABSTRACT FROM AUTHOR]

Published
2023
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108. 50: Prospective Neurocognitive Functions of Patients Treated with Concurrent Nivolumab and Stereotactic Brain Radiosurgery for NSCLC and RCC Brain Metastases

Author

Masucci, Giuseppina Laura, primary, Boucher, Olivier, additional, Florescu, Marie, additional, Plourde, Marc-Emile, additional, Ménard, Cynthia, additional, Masson-Côté, Laurence, additional, Panet-Raymond, Valérie, additional, Blais, Normand, additional, Routy, Bertrand, additional, Tehfé, Mustapha, additional, Owen, Scott, additional, Pavic, Michel, additional, Roberge, David, additional, and Wong, Philip, additional

Published
2021
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109. Venous thrombotic events in patients treated with immune checkpoint inhibitors for non-small cell lung cancer: A retrospective multicentric cohort study

Author

Deschênes-Simard, Xavier, primary, Richard, Corentin, additional, Galland, Loïck, additional, Blais, Florence, additional, Desilets, Antoine, additional, Malo, Julie, additional, Cvetkovic, Lena, additional, Belkaid, Wiam, additional, Elkrief, Arielle, additional, Gagné, Andréanne, additional, Hamel, Marc-André, additional, Orain, Michèle, additional, Joubert, Philippe, additional, Ghiringhelli, François, additional, Routy, Bertrand, additional, and Blais, Normand, additional

Published
2021
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110. CANCER IMMUNOTHERAPY: Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Author

Vétizou, Marie, Pitt, Jonathan M., Daillère, Romain, Lepage, Patricia, Waldschmitt, Nadine, Flament, Caroline, Rusakiewicz, Sylvie, Routy, Bertrand, Roberti, Maria P., Duong, Connie P. M., Poirier-Colame, Vichnou, Roux, Antoine, Becharef, Sonia, Formenti, Silvia, Golden, Encouse, Cording, Sascha, Eberl, Gerard, Schlitzer, Andreas, Ginhoux, Florent, Mani, Sridhar, Yamazaki, Takahiro, Jacquelot, Nicolas, Enot, David P., Bérard, Marion, Nigou, Jérôme, Opolon, Paule, Eggermont, Alexander, Woerther, Paul-Louis, Chachaty, Elisabeth, Chaput, Nathalie, Robert, Caroline, Mateus, Christina, Kroemer, Guido, Raoult, Didier, Boneca, Ivo Gomperts, Carbonnel, Franck, Chamaillard, Mathias, and Zitvogel, Laurence

Published
2015
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112. Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies

Author

Oster, Paul, primary, Vaillant, Laurie, additional, Riva, Erika, additional, McMillan, Brynn, additional, Begka, Christina, additional, Truntzer, Caroline, additional, Richard, Corentin, additional, Leblond, Marine M, additional, Messaoudene, Meriem, additional, Machremi, Elisavet, additional, Limagne, Emeric, additional, Ghiringhelli, Francois, additional, Routy, Bertrand, additional, Verdeil, Gregory, additional, and Velin, Dominique, additional

Published
2021
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113. Follicular helper-T cells restore CD8+-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy

Author

Niogret, Julie, primary, Berger, Hélène, additional, Rebe, Cédric, additional, Mary, Romain, additional, Ballot, Elise, additional, Truntzer, Caroline, additional, Thibaudin, Marion, additional, Derangère, Valentin, additional, Hibos, Christophe, additional, Hampe, Léa, additional, Rageot, David, additional, Accogli, Théo, additional, Joubert, Philippe, additional, Routy, Bertrand, additional, Harker, James, additional, Vegran, Frederique, additional, Ghiringhelli, Francois, additional, and Chalmin, Fanny, additional

Published
2021
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114. Cancer induces a stress ileopathy depending on B-adrenergic receptors and promoting dysbiosis that contribute to carcinogenesis

Author

Yonekura, Satoru, Terrisse, Safae, Alves Costa Silva, Carolina, Lafarge, Antoine, Iebba, Valerio, Ferrere, Gladys, Goubet, Anne-Gaelle, Fahrner, Jean-Eudes, Lahmar, Imran, Ueda, Kosuke, Mansouri, Gibrail, Pizzato, Eugenie, Ly, Pierre, Mazzenga, Marine, Thelemaque, Cassandra, Fidelle, Marine, Jaulin, Fanny, Cartry, Jerome, Deloger, Marc, Aglave, Marine, Droin, Nathalie, Opolon, Paule, Puget, Angelique, Mann, Fanny, Neunlist, Michel, Bessard, Anne, Aymeric, Laetitia, Matysiak-Budnik, Tamara, Bosq, Jacques, Hofman, Paul, Duong, Connie P M, Ugolini, Sophie, Quiniou, Valentin, Berrard, Sylvie, Ryffel, Bernhard, Kepp, Oliver, Kroemer, Guido, Routy, Bertrand, Lordello, Leonardo, Bani, Mohamed-Amine, Segata, Nicola, Yousef Yengej, Fjodor, Clevers, Hans, Scoazec, Jean-Yves, Pasolli, Edoardo, Derosa, Lisa, Zitvogel, Laurence, Yonekura, Satoru, Terrisse, Safae, Alves Costa Silva, Carolina, Lafarge, Antoine, Iebba, Valerio, Ferrere, Gladys, Goubet, Anne-Gaelle, Fahrner, Jean-Eudes, Lahmar, Imran, Ueda, Kosuke, Mansouri, Gibrail, Pizzato, Eugenie, Ly, Pierre, Mazzenga, Marine, Thelemaque, Cassandra, Fidelle, Marine, Jaulin, Fanny, Cartry, Jerome, Deloger, Marc, Aglave, Marine, Droin, Nathalie, Opolon, Paule, Puget, Angelique, Mann, Fanny, Neunlist, Michel, Bessard, Anne, Aymeric, Laetitia, Matysiak-Budnik, Tamara, Bosq, Jacques, Hofman, Paul, Duong, Connie P M, Ugolini, Sophie, Quiniou, Valentin, Berrard, Sylvie, Ryffel, Bernhard, Kepp, Oliver, Kroemer, Guido, Routy, Bertrand, Lordello, Leonardo, Bani, Mohamed-Amine, Segata, Nicola, Yousef Yengej, Fjodor, Clevers, Hans, Scoazec, Jean-Yves, Pasolli, Edoardo, Derosa, Lisa, and Zitvogel, Laurence

Abstract

Gut dysbiosis has been associated with intestinal and extra-intestinal malignancies but whether and how carcinogenesis drives compositional shifts of the microbiome to its own benefit remains an open conundrum. Here we show that malignant processes can cause ileal mucosa atrophy, with villous microvascular constriction associated with dominance of sympathetic over cholinergic signaling. Rapid onset of tumorigenesis induced a burst of Reg3y release by ileal cells, and transient epithelial barrier permeability that culminated in overt and long lasting dysbiosis dominated by Gram positive Clostridium species. Pharmacological blockade of B-adrenergic receptors or genetic deficiency in Adrb2 gene, vancomycin or co-housing of tumor bearers with tumor free littermates prevented cancer-induced ileopathy, eventually slowing tumor growth kinetics. Cancer patients harbor distinct hallmarks of this stress ileopathy dominated by Clostridium species. Hence, stress ileopathy is a corollary disease of extra-intestinal malignancies requiring specific therapies.

Published
2021

115. Immunodynamics of explanted human tumors for immuno‐oncology

Author

Dubuisson, Agathe, Fahrner, Jean Eudes, Goubet, Anne Gaëlle, Terrisse, Safae A., Voisin, Nicolas, Bayard, Charles, Lofek, Sébastien, Drubay, Damien, Bredel, Delphine, Mouraud, Séverine, Susini, Sandrine, Cogdill, Alexandria P., Rebuffet, Lucas, Ballot, Elise, Jacquelot, Nicolas, Thomas de Montpreville, Vincent, Casiraghi, Odile, Radulescu, Camélia, Ferlicot, Sophie, Figueroa, David J., Yadavilli, Sapna, Waight, Jeremy D., Ballas, Marc S., Hoos, Axel X., Condamine, Thomas, Parier, Bastien, Gaudillat, Christophe, Routy, Bertrand, Ghiringhelli, François, Derosa, Lisa, Breuskin, Ingrid, Rouanne, Mathieu, André, Fabrice, Lebacle, Cédric, Baumert, Hervé, Wislez, Marie, Fadel, Élie, Cremer, Isabelle, Albiges, Laurence, Geoerger, Birgit, Scoazec, Jean Yves, Loriot, Yohann, Kroemer, Guido, Marabelle, Aurélien, Bonvalet, Mélodie, Zitvogel, Laurence, Immunologie des tumeurs et immunothérapie (UMR 1015), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Gustave Roussy (IGR)-Université Paris-Sud - Paris 11 (UP11), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), The University of Texas M.D. Anderson Cancer Center [Houston], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER, The Walter and Eliza Hall Institute of Medical Research (WEHI), Département de biologie et pathologie médicales [Gustave Roussy], Institut Gustave Roussy (IGR), Centre hospitalier Saint-Joseph [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Département de médecine oncologique [Gustave Roussy], Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Foch [Suresnes], Direction de la recherche [Gustave Roussy], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Vectorologie et thérapeutiques anti-cancéreuses [Villejuif] (UMR 8203), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Karolinska University Hospital [Stockholm], Chancellerie des Universités de Paris Agence Nationale de la Recherche, ANR Seerave Foundation Association pour la Recherche sur le Cancer, ARC ANR‐16‐RHUS‐0008 Ligue Contre le Cancer European Commission, EC Fondation pour la Recherche Médicale, FRM Institut National Du Cancer, INCa Institut Universitaire de France, IUF European Research Council, ERC Fondation Leducq RP170067 Association pour la Recherche sur le Cancer, ARC, LZ and GK were supported by the Ligue contre le Cancer (équipe labelisée), Agence Nationale de la Recherche (ANR) francogermanique ANR‐19‐CE15‐0029, ANR Projects blancs, ANR under the frame of E‐Rare‐2, the ERA‐Net for Research on Rare Diseases, Association pour la recherche sur le cancer (ARC), Bristol‐Myers Squibb Company (International Immuno‐Oncology Network), Cancéropôle Ile‐de‐France, Chancellerie des universités de Paris (Legs Poix), Fondation pour la Recherche Médicale (FRM), a donation by Elior, the European Commission (ArtForce), the European Research Council (ERC), Fondation Carrefour, Institut National du Cancer (INCa), Inserm (HTE), Institut Universitaire de France, LeDucq Foundation, the LabEx Immuno‐Oncology, the RHU Torino Lumière (ANR‐16‐RHUS‐0008), H2020 ONCOBIOME, the Seerave Foundation, the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE), FHU CARE, Dassault, and Badinter Philantropia, and the Paris Alliance of Cancer Research Institutes (PACRI). AC is supported by the CPRIT Research Training Program (RP170067). JEF was supported by Transgene and AGG was supported by FRM. AM has been or is currently an investigator in clinical trials sponsored by BMS, MSD, GSK/Tesaro, Janssen, Roche/Genentech, Pfizer, Astra Zeneca (AZ), Amgen. AM has been or is currently a member of Clinical Trial Scientific Steering Committee for AZ and GSK. AM has been or is currently a member of the scientific advisory board of the following companies: Merck Serono, Novartis, BMS, Symphogen, Amgen, Tesaro/GSK, Pfizer, Astra Zeneca/Medimmune, Servier, Sanofi. AM has provided Scientific & Medical Consulting to the following companies: Roche, Sanofi. AM is a member of the Data Safety and Monitoring Board for the following trial NCT02423863 (TLR3 agonist, Oncovir). AM has received research funding and or drug supply for pre‐Clinical and clinical research projects from: BMS, Boehringer Ingelheim, Idera, MSD, Fondation MSD Avenir, SIRIC (INCa‐DGOS‐Inserm_12551)., ANR-16-RHUS-0008,LUMIERE,LUMIERE(2016), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPC)

Subjects
Medicine (General), [SDV]Life Sciences [q-bio], Immunology, QH426-470, Medical Oncology, immune checkpoint inhibitors, R5-920, immunomonitoring, Report, precision oncology, Neoplasms, Genetics, “in sitro” assay, Tumor Microenvironment, cancer, Humans, Immunotherapy, Prospective Studies, Reports
Abstract

Decision making in immuno‐oncology is pivotal to adapt therapy to the tumor microenvironment (TME) of the patient among the numerous options of monoclonal antibodies or small molecules. Predicting the best combinatorial regimen remains an unmet medical need. Here, we report a multiplex functional and dynamic immuno‐assay based on the capacity of the TME to respond to ex vivo stimulation with twelve immunomodulators including immune checkpoint inhibitors (ICI) in 43 human primary tumors. This "in sitro" (in situ/in vitro) assay has the potential to predict unresponsiveness to anti‐PD‐1 mAbs, and to detect the most appropriate and personalized combinatorial regimen. Prospective clinical trials are awaited to validate this in sitro assay., To predict cancer resistance to PD‐1 blockade and design suitable combinations of immunomodulators, a 60‐h functional in sitro assay was set up in 43 tumors that allowed calculation of the “Immune Reactivity Score (IRS)” based on 17 TCR‐dependent‐ cytokines/chemokines.

Published
2020

116. Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines

Author

Hajjar, Roy, Gonzalez, Emmanuel, Fragoso, Gabriela, Oliero, Manon, Alaoui, Ahmed Amine, Calvé, Annie, Vennin Rendos, Hervé, Djediai, Souad, Cuisiniere, Thibault, Laplante, Patrick, Gerkins, Claire, Ajayi, Ayodeji Samuel, Diop, Khoudia, Taleb, Nassima, Thérien, Sophie, Schampaert, Frédéricke, Alratrout, Hefzi, Dagbert, Francois, Loungnarath, Rasmy, Sebajang, Herawaty, Schwenter, Frank, Wassef, Ramses, Ratelle, Richard, Debroux, Eric, Cailhier, Jean-Francois, Routy, Bertrand, Annabi, Borhane, Brereton, Nicholas J B, Richard, Carole, and Santos, Manuela M

Abstract

ObjectiveColorectal cancer (CRC) is the third most diagnosed cancer, and requires surgical resection and reconnection, or anastomosis, of the remaining bowel to re-establish intestinal continuity. Anastomotic leak (AL) is a major complication that increases mortality and cancer recurrence. Our objective is to assess the causal role of gut microbiota in anastomotic healing.DesignThe causal role of gut microbiota was assessed in a murine AL model receiving faecal microbiota transplantation (FMT) from patients with CRC collected before surgery and who later developed or not, AL. Anastomotic healing and gut barrier integrity were assessed after surgery. Bacterial candidates implicated in anastomotic healing were identified using 16S rRNA gene sequencing and were isolated from faecal samples to be tested both in vitroand in vivo.ResultsMice receiving FMT from patients that developed AL displayed poor anastomotic healing. Profiling of gut microbiota of patients and mice after FMT revealed correlations between healing parameters and the relative abundance of Alistipes onderdonkiiand Parabacteroides goldsteinii. Oral supplementation with A. onderdonkiiresulted in a higher rate of leaks in mice, while gavage with P. goldsteiniiimproved healing by exerting an anti-inflammatory effect. Patients with AL and mice receiving FMT from AL patients presented upregulation of mucosal MIP-1α, MIP-2, MCP-1 and IL-17A/F before surgery. Retrospective analysis revealed that patients with AL present higher circulating neutrophil and monocyte counts before surgery.ConclusionGut microbiota plays an important role in surgical colonic healing in patients with CRC. The impact of these findings may extend to a vast array of invasive gastrointestinal procedures.

Published
2023
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118. Intestinal Akkermansia muciniphila predicts overall survival in advanced non-small cell lung cancer patients treated with anti-PD-1 antibodies: Results a phase II study.

Author

Derosa, Lisa, primary, Routy, Bertrand, additional, Zitvogel, Laurence, additional, Thomas, Andrew M., additional, Zalcman, Gerard, additional, Friard, Sylvie, additional, Mazieres, Julien, additional, Audigier-Valette, Clarisse, additional, Moro-Sibilot, Denis, additional, Goldwasser, Francois, additional, Richard, Corentin, additional, Ghiringhelli, François, additional, Barlesi, Fabrice, additional, Elkrief, Arielle, additional, Alves Costa Silva, Carolina, additional, Planchard, David, additional, Segata, Nicola, additional, Martinez, Stéphanie, additional, Soria, Jean-Charles, additional, and Besse, Benjamin, additional

Published
2021
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120. A phase II trial combining nivolumab and stereotactic brain radiosurgery for treatment of brain metastases in patients with NSCLC.

Author

Wong, Philip, primary, Florescu, Marie, additional, Plourde, Marc-Emile, additional, Panet-Raymond, Valerie, additional, Pavic, Michel, additional, Owen, Scott Peter, additional, Masson-Cote, Laurence, additional, Menard, Cynthia, additional, Routy, Bertrand, additional, Tehfe, Mustapha, additional, Blais, Normand, additional, Roberge, David, additional, and Masucci, Laura, additional

Published
2021
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121. Thrombotic events in patients treated with immune checkpoint inhibitors for non-small cell lung cancer: A retrospective multicentric cohort study.

Author

Deschenes-Simard, Xavier, primary, Galland, Loik, additional, Blais, Florence, additional, Desilets, Antoine, additional, Malo, Julie, additional, Cvetkovic, Lena, additional, Belkaid, Wiam, additional, Elkrief, Arielle, additional, Gagné, Andréanne, additional, Hamel, Marc-Andre, additional, Orain, Michèle, additional, Joubert, Philippe, additional, Ghiringhelli, François, additional, Routy, Bertrand, additional, and Blais, Normand, additional

Published
2021
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122. Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis

Author

Goubet, Anne-Gaëlle, primary, Dubuisson, Agathe, additional, Geraud, Arthur, additional, Danlos, François-Xavier, additional, Terrisse, Safae, additional, Alves Costa Silva, Carolina, additional, Drubay, Damien, additional, Touri, Lea, additional, Picard, Marion, additional, Mazzenga, Marine, additional, Silvin, Aymeric, additional, Dunsmore, Garett, additional, Haddad, Yacine, additional, Pizzato, Eugenie, additional, Ly, Pierre, additional, Flament, Caroline, additional, Melenotte, Cléa, additional, Solary, Eric, additional, Fontenay, Michaela, additional, Garcia, Gabriel, additional, Balleyguier, Corinne, additional, Lassau, Nathalie, additional, Maeurer, Markus, additional, Grajeda-Iglesias, Claudia, additional, Nirmalathasan, Nitharsshini, additional, Aprahamian, Fanny, additional, Durand, Sylvère, additional, Kepp, Oliver, additional, Ferrere, Gladys, additional, Thelemaque, Cassandra, additional, Lahmar, Imran, additional, Fahrner, Jean-Eudes, additional, Meziani, Lydia, additional, Ahmed-Belkacem, Abdelhakim, additional, Saïdani, Nadia, additional, La Scola, Bernard, additional, Raoult, Didier, additional, Gentile, Stéphanie, additional, Cortaredona, Sébastien, additional, Ippolito, Giuseppe, additional, Lelouvier, Benjamin, additional, Roulet, Alain, additional, Andre, Fabrice, additional, Barlesi, Fabrice, additional, Soria, Jean-Charles, additional, Pradon, Caroline, additional, Gallois, Emmanuelle, additional, Pommeret, Fanny, additional, Colomba, Emeline, additional, Ginhoux, Florent, additional, Kazandjian, Suzanne, additional, Elkrief, Arielle, additional, Routy, Bertrand, additional, Miyara, Makoto, additional, Gorochov, Guy, additional, Deutsch, Eric, additional, Albiges, Laurence, additional, Stoclin, Annabelle, additional, Gachot, Bertrand, additional, Florin, Anne, additional, Merad, Mansouria, additional, Scotte, Florian, additional, Assaad, Souad, additional, Kroemer, Guido, additional, Blay, Jean-Yves, additional, Marabelle, Aurélien, additional, Griscelli, Frank, additional, Zitvogel, Laurence, additional, and Derosa, Lisa, additional

Published
2021
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123. Circulating β-d-Glucan as a Marker of Subclinical Coronary Plaque in Antiretroviral Therapy-Treated People With Human Immunodeficiency Virus

Author

Isnard, Stéphane, primary, Fombuena, Brandon, additional, Sadouni, Manel, additional, Lin, John, additional, Richard, Corentin, additional, Routy, Bertrand, additional, Ouyang, Jing, additional, Ramendra, Rayoun, additional, Peng, Xiaorong, additional, Zhang, Yonglong, additional, Finkelman, Malcolm, additional, Tremblay-Sher, Daniel, additional, Tremblay, Cecile, additional, Chartrand-Lefebvre, Carl, additional, Durand, Madeleine, additional, and Routy, Jean-Pierre, additional

Published
2021
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126. Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

Author

Fluckiger, Aurelie, Daillere, Romain, Sassi, Mohamed, Sixt, Barbara Susanne, Liu, Peng, Loos, Friedemann, Richard, Corentin, Rabu, Catherine, Alou, Maryam Tidjani, Goubet, Anne-Gaelle, Lemaitre, Fabien, Ferrere, Gladys, Derosa, Lisa, Duong, Connie P. M., Messaoudene, Meriem, Gagne, Andreanne, Joubert, Philippe, De Sordi, Luisa, Debarbieux, Laurent, Simon, Sylvain, Scarlata, Clara-Maria, Ayyoub, Maha, Palermo, Belinda, Facciolo, Francesco, Boidot, Romain, Wheeler, Richard, Boneca, Ivo Gomperts, Sztupinszki, Zsofia, Papp, Krisztian, Csabai, Istvan, Pasolli, Edoardo, Segata, Nicola, Lopez-Otin, Carlos, Szallasi, Zoltan, Andre, Fabrice, Iebba, Valerio, Quiniou, Valentin, Klatzmann, David, Boukhalil, Jacques, Khelaifia, Saber, Raoult, Didier, Albiges, Laurence, Escudier, Bernard, Eggermont, Alexander, Mami-Chouaib, Fathia, Nistico, Paola, Ghiringhelli, Francois, Routy, Bertrand, Labarriere, Nathalie, Cattoir, Vincent, Kroemer, Guido, Zitvogel, Laurence, Fluckiger, Aurelie, Daillere, Romain, Sassi, Mohamed, Sixt, Barbara Susanne, Liu, Peng, Loos, Friedemann, Richard, Corentin, Rabu, Catherine, Alou, Maryam Tidjani, Goubet, Anne-Gaelle, Lemaitre, Fabien, Ferrere, Gladys, Derosa, Lisa, Duong, Connie P. M., Messaoudene, Meriem, Gagne, Andreanne, Joubert, Philippe, De Sordi, Luisa, Debarbieux, Laurent, Simon, Sylvain, Scarlata, Clara-Maria, Ayyoub, Maha, Palermo, Belinda, Facciolo, Francesco, Boidot, Romain, Wheeler, Richard, Boneca, Ivo Gomperts, Sztupinszki, Zsofia, Papp, Krisztian, Csabai, Istvan, Pasolli, Edoardo, Segata, Nicola, Lopez-Otin, Carlos, Szallasi, Zoltan, Andre, Fabrice, Iebba, Valerio, Quiniou, Valentin, Klatzmann, David, Boukhalil, Jacques, Khelaifia, Saber, Raoult, Didier, Albiges, Laurence, Escudier, Bernard, Eggermont, Alexander, Mami-Chouaib, Fathia, Nistico, Paola, Ghiringhelli, Francois, Routy, Bertrand, Labarriere, Nathalie, Cattoir, Vincent, Kroemer, Guido, and Zitvogel, Laurence

Abstract

Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae. Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2K(b)-restricted CD8(+) T lymphocyte response upon immunotherapy with cyclophosphamide or anti-PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in mice. In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP-cross-reactive antigen by tumors correlated with long-term benefit of PD-1 blockade therapy. In melanoma patients, T cell clones recognizing naturally processed cancer antigens that are cross-reactive with microbial peptides were detected.

Published
2020
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128. A Uniform Computational Approach Improved on Existing Pipelines to Reveal Microbiome Biomarkers of Nonresponse to Immune Checkpoint Inhibitors

Author

Shaikh, Fyza Y., primary, White, James R., additional, Gills, Joell J., additional, Hakozaki, Taiki, additional, Richard, Corentin, additional, Routy, Bertrand, additional, Okuma, Yusuke, additional, Usyk, Mykhaylo, additional, Pandey, Abhishek, additional, Weber, Jeffrey S., additional, Ahn, Jiyoung, additional, Lipson, Evan J., additional, Naidoo, Jarushka, additional, Pardoll, Drew M., additional, and Sears, Cynthia L., additional

Published
2021
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130. Durvalumab therapy following chemoradiation compared with a historical cohort treated with chemoradiation alone in patients with stage III non–small cell lung cancer: A real-world multicentre study

Author

Desilets, Antoine, primary, Blanc-Durand, Félix, additional, Lau, Sally, additional, Hakozaki, Taiki, additional, Kitadai, Rui, additional, Malo, Julie, additional, Belkaid, Wiam, additional, Richard, Corentin, additional, Messaoudene, Meriem, additional, Cvetkovic, Lena, additional, Kazandjian, Suzanne, additional, Tehfe, Mustapha, additional, Florescu, Marie, additional, Jao, Kevin, additional, Daaboul, Nathalie, additional, Owen, Scott, additional, Shieh, Benjamin, additional, Agulnik, Jason, additional, Cohen, Victor, additional, Charbonneau, Chloé, additional, Marcoux, Nicolas, additional, Blais, Normand, additional, Leighl, Natasha B., additional, Bradbury, Penelope A., additional, Liu, Geoffrey, additional, Shepherd, Frances A., additional, Bahig, Houda, additional, Routy, Bertrand, additional, Sacher, Adrian, additional, and Elkrief, Arielle, additional

Published
2021
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133. Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Author

Wargo, Jennifer, primary, Andrews, Miles, additional, Duong, Connie, additional, Gopalakrishnan, Vancheswaran, additional, Iebba, Valerio, additional, Chen, Wei-Shen, additional, Derosa, Lisa, additional, Routy, Bertrand, additional, Ferrere, Gladys, additional, Fluckiger, Aurélie, additional, Roberti, Maria, additional, Opolon, Paule, additional, Roh, Whijae, additional, Spencer, Christine, additional, Curbelo, Irina Fernandez, additional, Vence, Luis, additional, Reuben, Alexandre, additional, Cooper, Zachary, additional, Prieto, Peter, additional, Khan, M. A. Wadud, additional, Lazar, Alexander, additional, Tetzlaff, Michael, additional, Hudgens, Courtney, additional, Gaudreau, Pierre-Olivier, additional, Nezi, Luigi, additional, Raoult, Didier, additional, Haydu, Lauren, additional, Tawbi, Hussein, additional, Hwu, Patrick, additional, Hwu, Wen-Jen, additional, Amaria, Rodabe, additional, Burton, Elizabeth, additional, Woodman, Scott, additional, Diab, Adi, additional, Patel, Sapna, additional, Glitza, Isabella, additional, Zhang, Jianhua, additional, Ajami, Nadim, additional, Petrosino, Joseph, additional, Jenq, Robert, additional, Davies, Michael, additional, Gershenwald, Jeffrey, additional, Sharma, Padmanee, additional, Allison, James, additional, Futreal, Andrew, additional, Zitvogel, Laurence, additional, ALOU, Maryam TIDJANI, additional, Yonekura, Satoru, additional, Cogdill, Alexandria, additional, Arora, Reetakshi, additional, Little, Latasha, additional, Gumbs, Curtis, additional, Wani, Khalida, additional, Callahan, Margaret, additional, Adamow, Mathew, additional, Postow, Michael, additional, Ariyan, Charlotte, additional, Gardner, Julie, additional, McQuade, Jennifer, additional, Wong, Michael, additional, and Zhao, Li, additional

Published
2020
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134. Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

Author

Picard, Marion, primary, Yonekura, Satoru, additional, Slowicka, Karolina, additional, Petta, Ioanna, additional, Rauber, Conrad, additional, Routy, Bertrand, additional, Richard, Corentin, additional, Iebba, Valerio, additional, Tidjani Alou, Maryam, additional, Becharef, Sonia, additional, Ly, Pierre, additional, Pizzato, Eugenie, additional, Lehmann, Christian H. K., additional, Amon, Lukas, additional, Klein, Christophe, additional, Opolon, Paule, additional, Gomperts Boneca, Ivo, additional, Scoazec, Jean-Yves, additional, Hollebecque, Antoine, additional, Malka, David, additional, Ghiringhelli, François, additional, Dudziak, Diana, additional, Berx, Geert, additional, Vereecke, Lars, additional, van Loo, Geert, additional, Kroemer, Guido, additional, Zitvogel, Laurence, additional, and Roberti, Maria Paula, additional

Published
2020
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135. A Systematic Framework to Rapidly Obtain Data on Patients with Cancer and COVID-19: CCC19 Governance, Protocol, and Quality Assurance

Author

Abidi, Maheen, primary, Aboulafia, David M., additional, Accordino, Melissa K., additional, Acoba, Jared D., additional, Ahluwalia, Manmeet S., additional, Ahmad, Syed A., additional, Ajmera, Archana, additional, Alimohamed, Saif I., additional, Altman, Jessica, additional, Angevine, Anne H., additional, Bakouny, Ziad, additional, Bar, Michael H., additional, Bardia, Aditya, additional, Barnholtz-Sloan, Jill S., additional, Barrow McCollough, Briana, additional, Bashir, Babar, additional, Batist, Gerald, additional, Bekaii-Saab, Tanios S., additional, Berg, Stephanie, additional, Bernicker, Eric H., additional, Bhutani, Divaya, additional, Bilen, Mehmet A., additional, Bindal, Poorva, additional, Bishnoi, Rohit, additional, Blau, Sibel, additional, Bohachek, Pamela, additional, Boland, Genevieve, additional, Bonnen, Mark, additional, Bouchard, Gabrielle, additional, Bouganim, Nathaniel, additional, Bowles, Daniel W., additional, Busser, Fiona J., additional, Butt, Omar, additional, Cabal, Angelo, additional, Cabalona, Wilhelmina D., additional, Cabebe, Elwyn C., additional, Caimi, Paolo, additional, Campian, Jian L., additional, Carducci, Theresa M., additional, Chen, James L., additional, Cheng, Alex, additional, Chism, David D., additional, Choueiri, Toni K., additional, Clark, Melanie J., additional, Clement, Jessica M., additional, Connors, Jean M., additional, Cook, Erin, additional, Curran, Catherine R., additional, Daher, Ahmad, additional, Dailey, Mark E., additional, Davis, Elizabeth J., additional, Dawsey, Scott J., additional, Deeken, John F., additional, Del Prete, Salvatore A., additional, Demetri, George D., additional, Desai, Aakash, additional, Doroshow, Deborah B., additional, Durbin, Eric B., additional, Egan, Pamela C., additional, Elias, Rawad, additional, Elkrief, Arielle, additional, Elms, Destry J., additional, Elshoury, Amro, additional, Faller, Bryan, additional, Farmakiotis, Dimitrios, additional, Fecher, Leslie A., additional, Feldman, Lawrence E., additional, Ferrario, Cristiano, additional, Fiala, Mark A., additional, Flora, Daniel B., additional, French, Benjamin, additional, Friese, Christopher R., additional, Fu, Julie C., additional, Gadgeel, Shirish M., additional, Gainor, Justin, additional, Galsky, Matthew D., additional, Gantt, Gerald, additional, Garcia, Jorge A., additional, Gartrell, Benjamin A., additional, Gatti-Mays, Margaret E., additional, Gill, David M., additional, Gillaspie, Erin A., additional, Giordano, Antonio, additional, Glace, (Mary) Grace, additional, Glover, Michael J., additional, Goel, Sanjay, additional, Graber, Jerome J., additional, Griffiths, Elizabeth A., additional, Grivas, Petros, additional, Grover, Punita, additional, Gulati, Anthony P., additional, Gulati, Shuchi, additional, Gupta, Shilpa, additional, Gurley, Michael, additional, Hafez, Navid, additional, Halabi, Susan, additional, Halfdanarson, Thorvardur R., additional, Halmos, Balazs, additional, Hausrath, Daniel J., additional, Hawley, Jessica E., additional, Hennessy, Cassandra, additional, Herbst, Roy S., additional, Hershman, Dawn L., additional, Hoppenot, Claire, additional, Hoskins, Kent F., additional, Hoyo-Ulloa, Irma, additional, Hsu, Emily, additional, Hsu, Chih-Yuan, additional, Hwang, Clara, additional, Islam, Jessica Yasmine, additional, Jabbour, Salma K., additional, Jani, Chinmay, additional, Jha, Alokkumar, additional, Jhawar, Sachin R., additional, Johnson, Douglas B., additional, Joshi, Monika, additional, Kasi, Anup, additional, Kelleher, Kaitlin, additional, Kennecke, Hagen F., additional, Khaki, Ali Raza, additional, Khan, Hina, additional, Khan, Mahir, additional, Kharofa, Jordan, additional, Kloecker, Goetz, additional, Knoble, Jeanna L., additional, Kulkarni, Amit A., additional, Kumar, Vaibhav, additional, Lammers, Philip E., additional, Leighton, John C., additional, Lemmon, Christopher A., additional, Lewis, Mark A., additional, Li, Ang, additional, Li, Xuanyi, additional, Liu, Stephen V., additional, Lo, K.M., additional, Loaiza-Bonilla, Arturo, additional, Logan, Barbara B., additional, Loggers, Elizabeth T., additional, de Lima Lopes, Gilberto, additional, Loree, Jonathan M., additional, LoRusso, Patricia, additional, Low, Clarke A., additional, Lustberg, Maryam B., additional, Lyman, Gary H., additional, Lynch, Ryan C., additional, Madhavan, Subha, additional, Mahadevan, Daruka, additional, Mahmood, Sana Z., additional, Mansoor, Abdul-Hai, additional, Marcum, Michelle, additional, Markham, Merry-Jennifer, additional, Mashru, Sandeep H., additional, Masters, Tyler, additional, Mavromatis, Blanche H., additional, McKay, Rana R., additional, McNair, Christopher, additional, McWeeney, Shannon, additional, Menendez, Alvaro G., additional, Menon, Harry, additional, Mesa, Ruben A., additional, Mico, Vasil, additional, Miller, Chaim, additional, Mishra, Sanjay, additional, Monahan, Ryan S., additional, Morgans, Alicia K., additional, Mulcahy, Mary F., additional, Mundt, Daniel, additional, Mushtaq, Sarah, additional, Nagaraj, Gayathri, additional, Nagle, Sarah, additional, Nakasone, Elizabeth S., additional, Nakayama, John M., additional, Nelson, Heather H., additional, Nemecek, Eneida R., additional, Nguyen, Ryan H., additional, Nizam, Amanda, additional, Nohria, Anju, additional, Nuzzo, Pier Vitale, additional, Ohri, Nitin, additional, Olszewski, Adam J., additional, Owenby, Susie, additional, Painter, Corrie A., additional, Palmer, Joshua D., additional, Panagiotou, Orestis A., additional, Park, Cathleen, additional, Pasquinelli, Mary M., additional, Patel, Jaymin M., additional, Patel, Kanishka G., additional, Peddi, Prakash, additional, Pennell, Nathan A., additional, Peters, Solange, additional, Pilar, Christine, additional, Pillainayagam, Clement, additional, Puc, Matthew, additional, Ramirez, Amelie G., additional, Rathmann, Joerg, additional, Ravindranathan, Deepak, additional, Reid, Sonya A., additional, Reuben, Daniel Y., additional, Revankar, Sanjay G., additional, Reynolds, Kerry L., additional, Rho, Young Soo, additional, Rhodes, Terence D., additional, Rice, Robert L., additional, Riess, Jonathan, additional, Rini, Brian I., additional, Rink, Cameron, additional, Rosen, Lane R., additional, Rosenstein, Lori J., additional, Rosovsky, Rachel P., additional, Routy, Bertrand, additional, Rovito, Marc A., additional, Rubinstein, Samuel M., additional, Saif, M. Wasif, additional, Salazar, Mary, additional, Santos Dutra, Miriam, additional, Schapira, Lidia, additional, Schmidt, Andrew L., additional, Schroeder, Brett A., additional, Schwartz, Gary K., additional, Schwartz, Candice, additional, Schweizer, Michael T., additional, Serrano, Oscar K., additional, Shafer, Danielle A., additional, Shah, Pankil K., additional, Shah, Dimpy, additional, Shah, Mansi R., additional, Shah, Sumit A., additional, Shah, Chintan, additional, Shaw, Grace, additional, Shaya, Justin A., additional, Shyr, Yu, additional, Slosky, David A., additional, Smits, Melissa, additional, Solorzano, Carmen C., additional, Stauffer, Karen, additional, Stockerl-Goldstein, Keith E., additional, Stover, Daniel G., additional, Stratton, Jamie, additional, Stratton, Catherine, additional, Streckfuss, Mitrianna, additional, Subbiah, Suki, additional, Tachiki, Lisa, additional, Tadesse, Eyob, additional, Thompson, Michael A., additional, Topaloglu, Umit, additional, Tucker, Matthew D., additional, Van Allen, Eliezer M., additional, Van Loon, Susan, additional, Vega-Luna, Karen, additional, Venepalli, Neeta K., additional, Verma, Amit, additional, Vikas, Praveen, additional, Vinayak, Shaveta, additional, Vinh, Donald C., additional, Wagner, Michael J., additional, Wall, Sarah, additional, Wang, Lucy L., additional, Warner, Jeremy L., additional, Wehbe, Firas H., additional, Weinstein, Paul L., additional, Weiss, Matthias, additional, Weissmann, Lisa B., additional, Wildes, Tanya M., additional, Williams, Nicole, additional, Wise-Draper, Trisha M., additional, Wood, William A., additional, Wu, Julie Tsu-Yu, additional, Wulff-Burchfield, Elizabeth M., additional, Xie, Zhuoer, additional, Xu, Wenxin, additional, Yeh, Albert C., additional, Yu, Irene S., additional, Yu, Peter Paul, additional, Zacks, Rosemary, additional, Zaman, Qamar Ul, additional, Zaren, Howard, additional, Zhang, Tian, additional, Zhou, Alice Y., additional, Zhu, Huili, additional, Zon, Rebecca L., additional, and Zubiri, Leyre, additional

Published
2020
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136. 724 MUCOSA-ADHERENT BACTERIA REGULATE THE HEALING OF COLONIC ANASTOMOTIC WOUNDS IN COLORECTAL CANCER SURGERY

Author

Hajjar, Roy, Gonzalez, Emmanuel, Fragoso, Gabriela, Oliero, Manon, Alaoui, Ahmed A., Calvé, Annie, Rendos, Hervé Vennin, Djediai, Souad, Cuisiniere, Thibault, Laplante, Patrick, Gerkins, Claire, Ajayi, Ayodeji S., Diop, Khoudia, Taleb, Nassima, Thérien, Sophie, Schampaert, Frédéricke, Alratrout, Hefzi, Dagbert, François, Loungnarath, Rasmy, Sebajang, Herawaty, Schwenter, Frank, Wassef, Ramses, Ratelle, Richard, Debroux, Éric, Cailhier, Jean-François, Routy, Bertrand, Annabi, Borhane, Brereton, Nicholas J., Richard, Carole S., and Santos, Manuela M.

Published
2023
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138. Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies.

Author

Oster, Paul, Vaillant, Laurie, Riva, Erika, McMillan, Brynn, Begka, Christina, Truntzer, Caroline, Richard, Corentin, Leblond, Marine M, Messaoudene, Meriem, Machremi, Elisavet, Limagne, Emeric, Ghiringhelli, Francois, Routy, Bertrand, Verdeil, Gregory, and Velin, Dominique

Subjects
HELICOBACTER pylori infections, BACTEROIDES fragilis, DERMATOPHAGOIDES pteronyssinus, BACTERIAL colonies, TUMOR-infiltrating immune cells
Published
2022
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139. 681 Single pipeline re-analysis revises microbiome associations with anti-tumor response to checkpoint inhibitors

Author

Shaikh, Fyza, primary, White, James, additional, Gills, Joell, additional, Hakozaki, Taiki, additional, Corentin, Richard, additional, Routy, Bertrand, additional, Okuma, Yusuke, additional, Usyk, Mykhaylo, additional, Pandey, Abhishek, additional, Weber, Jeffrey, additional, Ahn, Jiyoung, additional, Naidoo, Jarushka, additional, Lipson, Evan, additional, Pardoll, Drew, additional, and Sears, Cynthia, additional

Published
2020
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140. 679 High fiber diet modifies gut microbiome, propionate production, intratumor immune response and is associated with outcome in patients with lung cancer treated with immune checkpoint inhibitors

Author

Richard, Corentin, primary, Benlaifaoui, Myriam, additional, Ouarzadi, Omar El, additional, Diop, Khoudia, additional, Desilets, Antoine, additional, Malo, Julie, additional, Belkaid, Wiam, additional, Leblanc, Andréanne, additional, Lamontagne, Julien, additional, Messaoudene, Meriem, additional, Elkrief, Arielle, additional, and Routy, Bertrand, additional

Published
2020
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141. High mortality among hospital-acquired COVID-19 infection in patients with cancer: A multicentre observational cohort study

Author

Elkrief, Arielle, primary, Desilets, Antoine, additional, Papneja, Neha, additional, Cvetkovic, Lena, additional, Groleau, Catherine, additional, Lakehal, Yahia Abdelali, additional, Shbat, Layla, additional, Richard, Corentin, additional, Malo, Julie, additional, Belkaid, Wiam, additional, Cook, Erin, additional, Doucet, Stéphane, additional, Tran, Thai Hoa, additional, Jao, Kevin, additional, Daaboul, Nathalie, additional, Bhang, Eric, additional, Loree, Jonathan M., additional, Miller, Wilson H., additional, Vinh, Donald C., additional, Bouganim, Nathaniel, additional, Batist, Gerald, additional, Letendre, Caroline, additional, and Routy, Bertrand, additional

Published
2020
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142. Physiologic colonic uptake of 18F-FDG on PET/CT is associated with clinical response and gut microbiome composition in patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors

Author

Cvetkovic, Lena, primary, Régis, Claudine, additional, Richard, Corentin, additional, Derosa, Lisa, additional, Leblond, Antoine, additional, Malo, Julie, additional, Messaoudene, Meriem, additional, Desilets, Antoine, additional, Belkaid, Wiam, additional, Elkrief, Arielle, additional, Routy, Bertrand, additional, and Juneau, Daniel, additional

Published
2020
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143. The Gut Microbiome Associates with Immune Checkpoint Inhibition Outcomes in Patients with Advanced Non–Small Cell Lung Cancer

Author

Hakozaki, Taiki, primary, Richard, Corentin, additional, Elkrief, Arielle, additional, Hosomi, Yukio, additional, Benlaïfaoui, Myriam, additional, Mimpen, Iris, additional, Terrisse, Safae, additional, Derosa, Lisa, additional, Zitvogel, Laurence, additional, Routy, Bertrand, additional, and Okuma, Yusuke, additional

Published
2020
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144. Abstract S12-01: High mortality among hospital-acquired COVID-19 infection in patients with cancer: An observational cohort study from Quebec and British Columbia

Author

Elkrief, Arielle, primary, Desilets, Antoine, additional, Papneja, Neha, additional, Cvetkovic, Lena, additional, Groleau, Catherine, additional, Lakehal, Yahia Abdelali, additional, Shbat, Layla, additional, Richard, Corentin, additional, Malo, Julie, additional, Belkaid, Wiam, additional, Cook, Erin, additional, Doucet, Stephane, additional, Tran, Thai Hoa, additional, Savard, Patrice, additional, Jao, Kevin, additional, Daaboul, Nathalie, additional, Bhang, Eric, additional, Loree, Jonathan, additional, Miller, Wilson, additional, Vinh, Donald, additional, Bouganim, Nathaniel, additional, Batist, Gerald, additional, Letendre, Caroline, additional, and Routy, Bertrand, additional

Published
2020
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145. Tepotinib Efficacy in a Patient with Non-Small Cell Lung Cancer with Brain Metastasis Harboring an HLA-DRB1-MET Gene Fusion

Author

Blanc-Durand, Félix, primary, Alameddine, Raafat, additional, Iafrate, Anthony J., additional, Tran-Thanh, Danh, additional, Lo, Ying-Chun, additional, Blais, Normand, additional, Routy, Bertrand, additional, Tehfé, Mustapha, additional, Leduc, Charles, additional, Romeo, Phillipe, additional, Stephenson, Phillipe, additional, and Florescu, Marie, additional

Published
2020
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146. Repurposing Metformin in Nondiabetic People With HIV: Influence on Weight and Gut Microbiota

Author

Isnard, Stéphane, primary, Lin, John, additional, Fombuena, Brandon, additional, Ouyang, Jing, additional, Varin, Thibault V, additional, Richard, Corentin, additional, Marette, André, additional, Ramendra, Rayoun, additional, Planas, Delphine, additional, Raymond Marchand, Laurence, additional, Messaoudene, Meriem, additional, Van der Ley, Claude P, additional, Kema, Ido P, additional, Sohail Ahmed, Darakhshan, additional, Zhang, Yonglong, additional, Finkelman, Malcolm, additional, Routy, Bertrand, additional, Angel, Jonathan, additional, Ancuta, Petronela, additional, and Routy, Jean-Pierre, additional

Published
2020
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148. Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage

Author

Fluckiger, Aurélie, primary, Daillère, Romain, additional, Sassi, Mohamed, additional, Sixt, Barbara Susanne, additional, Liu, Peng, additional, Loos, Friedemann, additional, Richard, Corentin, additional, Rabu, Catherine, additional, Alou, Maryam Tidjani, additional, Goubet, Anne-Gaëlle, additional, Lemaitre, Fabien, additional, Ferrere, Gladys, additional, Derosa, Lisa, additional, Duong, Connie P. M., additional, Messaoudene, Meriem, additional, Gagné, Andréanne, additional, Joubert, Philippe, additional, De Sordi, Luisa, additional, Debarbieux, Laurent, additional, Simon, Sylvain, additional, Scarlata, Clara-Maria, additional, Ayyoub, Maha, additional, Palermo, Belinda, additional, Facciolo, Francesco, additional, Boidot, Romain, additional, Wheeler, Richard, additional, Boneca, Ivo Gomperts, additional, Sztupinszki, Zsofia, additional, Papp, Krisztian, additional, Csabai, Istvan, additional, Pasolli, Edoardo, additional, Segata, Nicola, additional, Lopez-Otin, Carlos, additional, Szallasi, Zoltan, additional, Andre, Fabrice, additional, Iebba, Valerio, additional, Quiniou, Valentin, additional, Klatzmann, David, additional, Boukhalil, Jacques, additional, Khelaifia, Saber, additional, Raoult, Didier, additional, Albiges, Laurence, additional, Escudier, Bernard, additional, Eggermont, Alexander, additional, Mami-Chouaib, Fathia, additional, Nistico, Paola, additional, Ghiringhelli, François, additional, Routy, Bertrand, additional, Labarrière, Nathalie, additional, Cattoir, Vincent, additional, Kroemer, Guido, additional, and Zitvogel, Laurence, additional

Published
2020
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149. Abstract 5730: A new polyphenol prebiotic isolated from Myrciaria dubia improves gut microbiota composition and increases anti-PD-1 efficacy in murine cancer models

Author

Messaoudene, Meriem, primary, Cauchois, Florent, additional, Piedgeon, Reilly, additional, Diop, Khoudia, additional, Richard, Corentin, additional, Varin, Thibault, additional, Trottier, Jocelyn, additional, Barbier, Olivier, additional, Pilon, Geneviève, additional, Turcotte, Simon, additional, Marette, André, additional, Castagner, Bastien, additional, and Routy, Bertrand, additional

Published
2020
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150. Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients

Author

Derosa, Lisa, primary, Routy, Bertrand, additional, Fidelle, Marine, additional, Iebba, Valerio, additional, Alla, Laurie, additional, Pasolli, Edoardo, additional, Segata, Nicola, additional, Desnoyer, Aude, additional, Pietrantonio, Filippo, additional, Ferrere, Gladys, additional, Fahrner, Jean-Eudes, additional, Le Chatellier, Emmanuelle, additional, Pons, Nicolas, additional, Galleron, Nathalie, additional, Roume, Hugo, additional, Duong, Connie P.M., additional, Mondragón, Laura, additional, Iribarren, Kristina, additional, Bonvalet, Mélodie, additional, Terrisse, Safae, additional, Rauber, Conrad, additional, Goubet, Anne-Gaëlle, additional, Daillère, Romain, additional, Lemaitre, Fabien, additional, Reni, Anna, additional, Casu, Beatrice, additional, Alou, Maryam Tidjani, additional, Alves Costa Silva, Carolina, additional, Raoult, Didier, additional, Fizazi, Karim, additional, Escudier, Bernard, additional, Kroemer, Guido, additional, Albiges, Laurence, additional, and Zitvogel, Laurence, additional

Published
2020
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