Search

Purpose: In this study, we aimed to investigate the utilization of 68Ga-FAPI PET/CT in comparison to 18FDG PET/CT to evaluate the peritoneal involvement of the gastrointestinal malignancies alongside primary lesions and other metastatic foci. Procedures: A total of 37 patients with various gastrointestinal malignancies with accompanying peritoneal involvement who underwent 68Ga-FAPI PET/CT and 18FDG PET/CT imaging between September 2020 and June 2021 were included in this retrospective study. SUVmax values of 68Ga-FAPI and 18FDG were compared according to lesion locations. Also, the lesion localization ability of both imaging was compared in patient basis. Results: Of the 37 patients with peritoneal involvement (23 males and 14 females; median age, 62.8 ± 12.7 years), 35.1% (n = 13) had colorectal cancer, 37.8% (n = 14) gastric cancer, and 27.0% (n = 10) pancreaticobiliary cancer. While 45.9% of them were operated, the remaining did not have surgery. The mean time interval between two studies was 3.2 days (range: 2–6 days). The mean SUVmax value of peritoneal metastases (p < 0.001) was significantly higher with 68Ga-FAPI PET/CT compared to that with 18FDG PET/CT, as in primary lesions (p < 0.001), lymph node metastases (p = 0.006), liver metastases (p = 0.002), and bone metastases (p = 0.018). A total of 185 lesions was detected in the initial assessment with 18FDG PET/CT. Of the total lesions detected with 18FDG PET/CT, 5 of them were evaluated as benign lesions with 68Ga-FAPI PET/CT also in accordance with the reference standard. In addition to 180 lesions detected with 18FDG PET/CT, a total of 37 additional malignant lesions, 12 of which were peritoneal metastases, were detected with 68Ga-FAPI PET/CT. Conclusion: 68Ga-FAPI PET/CT was determined to be superior to 18FDG PET/CT in terms of detection of peritoneal involvement with high image quality as well as primary tumor and other metastatic foci. Consequently, 68Ga-FAPI PET/CT can be used as a complementary imaging modality especially for inconclusive 18FDG findings due to the lack of accuracy of 18FDG PET/CT in some of the metastatic regions, especially in the liver. [ABSTRACT FROM AUTHOR]

Recently, sustainability in terms of making the life of humanity permanent is being by far the most important subject. In this study, the production of cocoa bean shell fat, a by-product obtained from supercritical carbon dioxide (SC-CO2) extraction, and cocoa butter were compared in terms of antioxidant capacity, fatty acid composition, and flavor profile. In addition, Soxhlet method was used for the comparison of extraction yield. Extract of cocoa bean shell was obtained by supercritical extraction method with 70% yield. Fatty acid composition and flavor profile were determined using Gas Chromatography/Mass Spectrometry (GC-MS) and Dynamic Headspace-GC/MS, respectively. The yield of the cocoa bean shell extract was 4.15% at Soxhlet and 15.09% and 10.31% at SC-CO2 extraction. The fatty acid constituents extracted using SC-CO2 ranged from 23.62% to 23.72% palmitic acid, 30.83% to 31.28% stearic acid, 32.19% to 32.41% oleic acid, and 9.35% to 9.61% linoleic acid. Physicochemical properties and fatty acid composition of SC-CO2 extracted cocoa bean shell fats content were found to be comparable to that of commercial cocoa butter. Antioxidant capacity of the obtained extract in terms of β-carotene linoleic acid method and total phenolic content were found to be lower than that of cocoa butter. [ABSTRACT FROM AUTHOR]

Purpose: We compared the ability of 68Ga-FAPI PET//CT with 18FDG PET/CT imaging techniques to detect additional lesions in breast cancer patients that may affect further chemotherapy options.Methods: A total of 48 patients with breast cancer underwent concurrent 68Ga-FAPI-04 and 18FDG PET/CT regardless of whether they had received chemotherapy or not in the last month before imaging. Both modalities were compared according to various parameters: clinical/pathological features, number of lesions detected, activity uptake (SUVmax), and the effect on the evaluation of response to treatment in the post-chemotherapy group.Results: This retrospective study included 48 patients with breast cancer (mean age 53.3 ± 11.7 years; IDC 89.6%; ILC 10.4%). In the comparison of both modalities, no statistical significance was obtained in terms of the pathological characteristics of the patients. More lesions were demonstrated in all categorized regions in 68Ga-FAPI PET/CT imaging with higher uptake values compared to 18FDG PET/CT in this study. In the treatment response evaluation of the post-chemotherapy group, 12 cases (12/24) who were evaluated as PMR, CMR, or SD according to 18FDG PET/CT results were later accepted as PD due to newly detected lesions in complementary 68Ga-FAPI PET/CT imaging and treatment of patients was managed accordingly by clinicians.Conclusion: It was determined that 68Ga-FAPI PET/CT was superior to 18FDG PET/CT in terms of accuracy and it was thought that 68Ga-FAPI PET/CT could be utilized as an additional complementary imaging to 18FDG PET/CT. Moreover, 68Ga-FAPI PET/CT, with its significant theranostic potential, could become a key element in predicting the pathological response of breast cancer patients in further researches. [ABSTRACT FROM AUTHOR]

Claisen rearrangement is used for stereoselectively generating quaternary oxonitriles from the union of five-, six- and seven-membered 2-chloroalkenecarbonitriles with chiral alcohols. Subsequent thermolysis has unmasked a cyclic oxonitrile while selectively forming a new quaternary center with enantiomeric ratios greater than 9:1 and the alkylation strategy has addressed the challenge of enantioselectively generating quaternary centers while installing ketone, nitrile and oelfin functionalities.

A study related to the high diastereoselectivity observed for the aziridinations of chiral allylic alcohols with acetoxyaminoquinazolinone (Q-NHOAc) is presented. The observed selectivity is demonstrated in terms of hydrogen bonding between the hydroxy functionality of the allylic alcohol and the remote carbonyl group of the quinazolinone.

The article explains the synthesis, structures and stereogenism of various N/O spirocyclic phosphazene derivatives. The steric and electronic factors highly affect the properties of these phosphorus-nitrogen compounds.

The study presents a detailed analysis of the reactions of the benzonorbornadiene and 7-heterobenzonorbornadienes with several 1,3-dicarbonyl compounds, containing the unusual manganese(III)-mediated oxidative free radical. The results have proved that the reactions always produce rearranged products, as the cyclization reaction always takes place after the oxidation of the radical that is formed initially.