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111. Predictive models for occurrence of expansive intracranial hematomas and surgical evacuation outcomes in traumatic brain injury patients in Uganda: A prospective cohort study

Author

Kamabu, Larrey Kasereka, primary, Oboth, Ronald, additional, Bbosa, Godfrey, additional, Baptist, Ssenyondwa John, additional, Kaddumukasa, Martin N., additional, Deng, Daniel, additional, Lekuya, Hervé Monka, additional, Kataka, Louange Maha, additional, Kiryabwire, Joel, additional, Moses, Galukande, additional, Sajatovic, Martha, additional, Kaddumukasa, Mark, additional, and Fuller, Anthony T., additional

Published
2023
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113. Fibrinogen; a predictor of injury severity and mortality among patients with traumatic brain injury in Sub-Saharan Africa: A cross-sectional observational study

Author

John Baptist, Ssenyondwa, primary, Joel, Kiryabwire, additional, Kaddumukasa, Martin, additional, Michael, Devereaux, additional, Kasereka Kamabu, Larrey, additional, Galukande, Moses, additional, Kaddumukasa, Mark, additional, Sajatovic, Martha, additional, and Timothy Kabanda, Makumbi, additional

Published
2023
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115. Sex Differences Among Older Adults With Bipolar Disorder: Results From the Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project

Author

Blanken, Machteld A.J.T., primary, Oudega, Mardien L., additional, Almeida, Osvaldo P., additional, Schouws, Sigfried N.T.M., additional, Orhan, Melis, additional, Beunders, Alexandra J.M., additional, Klumpers, Ursula M.H., additional, Sonnenberg, Caroline, additional, Blumberg, Hilary P., additional, Eyler, Lisa T., additional, Forester, Brent P., additional, Forlenza, Orestes V., additional, Gildengers, Ariel, additional, Mulsant, Benoit H., additional, Rajji, Tarek, additional, Rej, Soham, additional, Sarna, Kaylee, additional, Sutherland, Ashley, additional, Yala, Joy, additional, Vieta, Eduard, additional, Tsai, Shangying, additional, Briggs, Farren B.S., additional, Sajatovic, Martha, additional, and Dols, Annemiek, additional

Published
2023
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116. 3.3 Association Between Symptom Severity and Medication Adherence in Adolescents and Young Adults With Bipolar Disorder Demonstrating Suboptimal Adherence

Author

DelBello, Melissa P., primary, Levin, Jennifer, additional, Modi, Avani C., additional, McVoy, Molly, additional, Black, Jessica, additional, Cooley, Raechel, additional, Briggs, Farren, additional, Sarna, Kaylee, additional, Forthun, Larry F., additional, and Sajatovic, Martha, additional

Published
2023
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118. Predictors of Functional Impairment in Bipolar Disorder: Results From 13 Cohorts From Seven Countries by the Global Bipolar Cohort Collaborative

Author

Burdick, Katherine E., primary, Millett, Caitlin E., additional, Yocum, Anastasia K., additional, Altimus, Cara M., additional, Andreassen, Ole A., additional, Aubin, Valerie, additional, Belzeaux, Raoul, additional, Berk, Michael, additional, Biernacka, Joanna M., additional, Blumberg, Hilary P., additional, Cleare, Anthony J., additional, Diaz-Byrd, Claudia, additional, Dubertret, Caroline, additional, Etain, Bruno, additional, Eyler, Lisa T., additional, Forester, Brent P., additional, Fullerton, Janice M., additional, Frye, Mark A., additional, Gard, Sébastien, additional, Godin, Ophelia, additional, Haffen, Emmanuel, additional, Klaus, Federica, additional, Lagerberg, Trine Vik, additional, Leboyer, Marion, additional, Martinez-Aran, Anabel, additional, McElroy, Susan, additional, Mitchell, Philip B., additional, Olie, Emilie, additional, Olorunfemi, Phebe, additional, Passerieux, Christine, additional, Peters, Amy T., additional, Pham, Daniel L., additional, Polosan, Mircea, additional, Potter, Julia R., additional, Sajatovic, Martha, additional, Samalin, Ludovic, additional, Schwan, Raymund, additional, Shanahan, Megan, additional, Solé, Brisa, additional, Strawbridge, Rebecca, additional, Stuart, Amanda L., additional, Torres, Ivan, additional, Ueland, Torrill, additional, Vieta, Eduard, additional, Williams, Lana J., additional, Wrobel, Anna L., additional, Yatham, Lakshmi N., additional, Young, Allan H., additional, Nierenberg, Andrew A., additional, and McInnis, Melvin G., additional

Published
2023
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126. Contributors

Author

Ahearn, Eileen, primary, Al Mugaddam, Fadwa, additional, Amore, M., additional, Anastasia, A., additional, Andrews, Taylor, additional, Anmella, Gerard, additional, Arnone, Danilo, additional, Ashdown-Franks, Garcia, additional, Aziz, Karim Abdel, additional, Barichello, Tatiana, additional, Bauer, Moisés E., additional, Baune, Bernhard T., additional, Bellani, Marcella, additional, Bellivier, Frank, additional, Benedetti, Francesco, additional, Benevenuto, Deborah, additional, Bock, Nicholas A., additional, Bora, Emre, additional, Brambilla, Paolo, additional, Brunoni, Andre Russowsky, additional, Calabrese, Joseph R., additional, Camino, Sebastián, additional, Cararo, José H., additional, Carvalho, Andre Ferrer, additional, Ceylan, Deniz, additional, Chakrabarty, Trisha, additional, Chen, Peijun, additional, Cipriani, N., additional, Collodel, Allan, additional, Colombo, C., additional, Dallaspezia, Sara, additional, Del Fabro, Lorenzo, additional, DelBello, Melissa P., additional, Delvecchio, Giuseppe, additional, Doifode, Tejaswini, additional, DuBow, Anaïs, additional, Etain, Bruno, additional, Farrow, Jenni E., additional, Fernandes, Brisa S., additional, Fornaro, M., additional, Fregna, L., additional, Frey, Benicio N., additional, Fries, Gabriel R., additional, Fusco, A., additional, Gao, Keming, additional, Garza, Jacob C., additional, Gava, Fernanda F., additional, Generoso, Jaqueline S., additional, Giménez, Anna, additional, Giridharan, Vijayasree, additional, Goldstein, Benjamin I., additional, Gomes-da-Costa, Susana, additional, Grande, Iria, additional, Haggarty, Stephen J., additional, Hennion, Vincent, additional, Husain, Muhammad I., additional, Juster, Robert-Paul, additional, Kato, Tadafumi, additional, Keramatian, Kamyar, additional, Kloiber, Stefan, additional, Lima, Camila Nayane de Carvalho, additional, Locatelli, M., additional, Machado-Vieira, Rodrigo, additional, Melun, Jean-Pierre, additional, Meyer, Jeffrey H., additional, Mio, Megan, additional, Murru, Andrea, additional, Nery, Fabiano G., additional, Özerdem, Ayşegül, additional, Pacchiarotti, Isabella, additional, Pariante, Carmine Maria, additional, Patino, Luis Rodrigo, additional, Perlis, Roy H., additional, Pilieci, Christopher, additional, Pinjari, Omar F., additional, Pink, Omar, additional, Pinto, Jairo Vinícius, additional, Pisanu, Claudia, additional, Quevedo, Joao, additional, Rosenblat, Joshua D., additional, Sabiston, Catherine M., additional, Sajatovic, Martha, additional, Salagre, Estela, additional, de Sampaio Pereira Júnior, Bernardo, additional, Saraf, Gayatri, additional, Scaini, Giselli, additional, Seghi, F., additional, Sehmbi, Manpreet, additional, Serafini, G., additional, Sforzini, Luca, additional, Shahani, Lokesh, additional, Singhal, Gaurav, additional, Squassina, Alessio, additional, Stertz, Laura, additional, Teixeira, Antonio L., additional, Trinetti, Jessica, additional, Valvassori, Samira S., additional, Vázquez, Gustavo, additional, Vieta, Eduard, additional, Walss-Bass, Consuelo, additional, Wieck, Andrea, additional, Yatham, Lakshmi N., additional, and Zhao, Wen-Ning, additional

Published
2021
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131. Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project.

Author

Chen, Peijun, Sajatovic, Martha, Briggs, Farren B. S., Mulsant, Benoit, Dols, Annemiek A., Gildengers, Ariel, Yala, Joy, Beunders, Alexandra J. M., Blumberg, Hilary P., Rej, Soham, Forlenza, Orestes V., Jimenez, Esther, Schouws, Sigfried, Orhan, Melis, Sutherland, Ashley N., Vieta, Eduard, Tsai, Shangying, Sarna, Kaylee, and Eyler, Lisa T.

Subjects
*CROSS-sectional method, *FUNCTIONAL status, *WORLD health, *AGING, *DESCRIPTIVE statistics, *RESEARCH funding, *MENTAL depression, *SOCIODEMOGRAPHIC factors, *LOGISTIC regression analysis, *BIPOLAR disorder, *PSYCHOLOGICAL resilience, *COMORBIDITY, *SYMPTOMS, *OLD age, *MIDDLE age
Abstract

Objects: Studies of older age bipolar disorder (OABD) have mostly focused on "younger old" individuals. Little is known about the oldest OABD (OOABD) individuals aged ≥70 years old. The Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project provides an opportunity to evaluate the OOABD group to understand their characteristics compared to younger groups. Methods: We conducted cross‐sectional analyses of the GAGE‐BD database, an integrated, harmonized dataset from 19 international studies. We compared the sociodemographic and clinical characteristics of those aged <50 (YABD, n = 184), 50–69 (OABD, n = 881), and ≥70 (OOABD, n = 304). To standardize the comparisons between age categories and all characteristics, we used multinomial logistic regression models with age category as the dependent variable, with each characteristic as the independent variable, and clustering of standard errors to account for the correlation between observations from each of the studies. Results: OOABD and OABD had lower severity of manic symptoms (Mean YMRS = 3.3, 3.8 respectively) than YABD (YMRS = 7.6), and lower depressive symptoms (% of absent = 65.4%, and 59.5% respectively) than YABD (18.3%). OOABD and OABD had higher physical burden than YABD, especially in the cardiovascular domain (prevalence = 65% in OOABD, 41% in OABD and 17% in YABD); OOABD had the highest prevalence (56%) in the musculoskeletal domain (significantly differed from 39% in OABD and 31% in YABD which didn't differ from each other). Overall, OOABD had significant cumulative physical burden in numbers of domains (mean = 4) compared to both OABD (mean = 2) and YABD (mean = 1). OOABD had the lowest rates of suicidal thoughts (10%), which significantly differed from YABD (26%) though didn't differ from OABD (21%). Functional status was higher in both OOABD (GAF = 63) and OABD (GAF = 64), though only OABD had significantly higher function than YABD (GAF = 59). Conclusions: OOABD have unique features, suggesting that (1) OOABD individuals may be easier to manage psychiatrically, but require more attention to comorbid physical conditions; (2) OOABD is a survivor cohort associated with resilience despite high medical burden, warranting both qualitative and quantitative methods to better understand how to advance clinical care and ways to age successfully with BD. Key points: Limited knowledge of older and oldest older age bipolar disorder derived from limited sample sizes.The Global Aging and Geriatric Experiments in Bipolar Disorder consortium provided international data to compare younger age, older age, and oldest older age people with BDInternational sites (n = 14) provided data on patients aged <50 (n = 184 YABD), 50–69 (n = 881 OABD), and ≥70 (n = 304 OOABD) to assess differences among three groupsOABD and OOABD represent distinct cohorts within BD and differ in sociodemographic and clinical characteristics from YABD in general. OOABD individuals may be easier to manage psychiatrically but require more attention to their comorbid physical conditions. OOABD likely is a survivor cohort associated with resilience despite high medical burden, warranting future study using both qualitative and quantitative methods to better understand what makes OOABD resilient, how to advance clinical care and age successfully with BD. [ABSTRACT FROM AUTHOR]

Published
2024
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132. Demographic and clinical associations to employment status in older‐age bipolar disorder: Analysis from the GAGE‐BD database project.

Author

Mallu, Amulya, Chan, Carol K., Eyler, Lisa T., Dols, Annemiek, Rej, Soham, Blumberg, Hilary P., Sarna, Kaylee, Forester, Brent P., Patrick, Regan E., Forlenza, Orestes V., Jimenez, Esther, Vieta, Eduard, Schouws, Sigfried, Sutherland, Ashley, Yala, Joy, Briggs, Farren B. S., and Sajatovic, Martha

Subjects
BIPOLAR disorder, ALCOHOLISM, DATABASES, OLDER people, EMPLOYMENT
Abstract

Objective: The current literature on employment in older adults with bipolar disorder (OABD) is limited. Using the Global Aging and Geriatric Experiments in Bipolar Disorder Database (GAGE‐BD), we examined the relationship of occupational status in OABD to other demographic and clinical characteristics. Methods: Seven hundred and thirty‐eight participants from 11 international samples with data on educational level and occupational status were included. Employment status was dichotomized as employed versus unemployed. Generalized linear mixed models with random intercepts for the study cohort were used to examine the relationship between baseline characteristics and employment. Predictors in the models included baseline demographics, education, psychiatric symptom severity, psychiatric comorbidity, somatic comorbidity, and prior psychiatric hospitalizations. Results: In the sample, 23.6% (n = 174) were employed, while 76.4% were unemployed (n = 564). In multivariable logistic regression models, less education, older age, a history of both anxiety and substance/alcohol use disorders, more prior psychiatric hospitalizations, and higher levels of BD depression severity were associated with greater odds of unemployment. In the subsample of individuals less than 65 years of age, findings were similar. No significant association between manic symptoms, gender, age of onset, or employment status was observed. Conclusion: Results suggest an association between educational level, age, psychiatric severity and comorbidity in relation to employment in OABD. Implications include the need for management of psychiatric symptoms and comorbidity across the lifespan, as well as improving educational access for people with BD and skills training or other support for those with work‐life breaks to re‐enter employment and optimize the overall outcome. [ABSTRACT FROM AUTHOR]

Published
2023
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133. Highlights From the Annual Meeting of the American Epilepsy Society 2022

Author

Valencia, Ignacio, primary, Alexander, Allyson L., additional, Andrade, Danielle M., additional, Arevalo-Astrada, Miguel, additional, Rubiños, Clio, additional, Auer, Nancy, additional, Bainbridge, Jacquelyn L., additional, Baxendale, Sallie A., additional, Bartolomei, Fabrice, additional, Becker, Danielle A., additional, Berg, Anne T., additional, Bernasconi, Andrea, additional, Bernasconi, Neda, additional, Bernhardt, Boris, additional, Bhatnagar, Shivani, additional, Blümcke, Ingmar, additional, Blumenfeld, Hal, additional, Buchanan, Gordon F., additional, Burdette, David E., additional, Burneo, Jorge G., additional, Busch, Robyn M., additional, Chauvel, Patrick, additional, Chin, Jeannie, additional, Clifford, Lisa, additional, Conner, Kelly R., additional, Cook, Mark J., additional, Conway, Jeannine, additional, Diaz-Arastia, Ramon, additional, Drees, Cornelia, additional, French, Jacqueline A., additional, Ganguly, Taneeta Mindy, additional, Gelfand, Michael A., additional, Glauser, Tracy A., additional, Gleichgerrcht, Ezequiel, additional, Goldman, Alica M., additional, Gonzalez-Martinez, Jorge, additional, Gotman, Jean, additional, Grinspan, Zachary, additional, Guilfoyle, Shanna, additional, Gupta, Gita, additional, Hammer, Michael, additional, Hartman, Adam L., additional, Hentges, Katie, additional, Hogan, R. Edward, additional, Huh, Linda, additional, Hyslop, Ann, additional, Jobst, Barbara, additional, Josephson, Colin B., additional, Kelley, Sarah A., additional, Knupp, Kelly, additional, Koepp, Matthias, additional, Kothare, Sanjeev V., additional, Krook-Magnuson, Esther, additional, Kwasa, Jasmine, additional, La Vega-Talbott, Maite, additional, Lam, Alice D., additional, Lee, Jong Woo, additional, Lowenstein, Daniel H., additional, Maturu, Sarita, additional, Mayor, Luis Carlos, additional, McDonald, Carrie, additional, McKee, Heather R., additional, McKhann, Guy M., additional, Meador, Kimford J., additional, Mefford, Heather C., additional, Michael, Elizabeth H., additional, Mikati, Mohamad A., additional, Millichap, John J., additional, Mitchell, James W., additional, Myers, Leah S., additional, Naritoku, Dean, additional, Neville, Kerri L., additional, Noebels, Jeffrey, additional, O’Brien, Terence J., additional, Oluigbo, Chima O., additional, Patel, Anup D., additional, Pavlova, Milena K., additional, T. Paz, Jeanne, additional, Pennell, Page B., additional, Perry, M. Scott, additional, Perucca, Piero, additional, Pitkänen, Asla, additional, Plueger, Madona, additional, Pugh, Mary Jo, additional, Quigg, Mark, additional, Reddy, Shilpa B., additional, Ryan, Christopher, additional, Reynolds, Tamara S., additional, Sajatovic, Martha, additional, Santana-Gomez, Cesar, additional, Schommer, Linsday, additional, Schuele, Stephan, additional, Shellhaas, Renée A., additional, Shrey, Daniel W., additional, Singh, Rani K., additional, Sperling, Michael R., additional, Suleman, Saher, additional, Templer, Jessica W., additional, Thom, Maria, additional, Trinka, Eugen, additional, Varadkar, Sophia M., additional, Velez-Ruiz, Naymee, additional, Velíšková, Jana, additional, Voskobiynyk, Yuliya, additional, Wagner, Janelle L., additional, Wagnon, Jacy L., additional, Waller, Claire, additional, Waller, Jill, additional, Wang, Zhong Irene, additional, Welborn, Michelle W., additional, and Wirrell, Elaine, additional

Published
2023
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141. Cingulum bundle connectivity in treatment-refractory compared to treatment-responsive patients with bipolar disorder and healthy controls: a tractography and surgical targeting analysis

Author

Sweet, Jennifer A., Gao, Keming, Chen, Zhengyi, Tatsuoka, Curtis, Calabrese, Joseph R., Sajatovic, Martha, Miller, Jonathan P., and McIntyre, Cameron C.

Subjects
Clinical Article, General Medicine, behavioral disciplines and activities
Abstract

OBJECTIVE The clinical response of patients with bipolar disorder to medical treatment is variable. A better understanding of the underlying neural circuitry involved in bipolar treatment responsivity subtypes may provide insight into treatment resistance and aid in identifying an effective surgical target for deep brain stimulation (DBS) specific to the disorder. Despite considerable imaging research related to the disease, a paucity of comparative imaging analyses of treatment responsiveness exists. There are also no DBS targets designed expressly for patients with bipolar disorder. Therefore, the authors analyzed cingulum bundle axonal connectivity in relation to cortico-striatal-thalamo-cortical (CSTC) loops implicated in bipolar disorder across subjects who are responsive to treatment (RSP) and those who are refractory to therapy (REF), compared to healthy controls (HCs). METHODS Twenty-five subjects with bipolar disorder (13 RSP and 12 REF), diagnosed using the Mini International Neuropsychiatric Interview and classified with standardized rating scales, and 14 HCs underwent MRI with diffusion sequences for probabilistic diffusion-weighted tractography analysis. Image processing and tractography were performed using MRTrix. Region of interest (ROI) masks were created manually for 10 anterior cingulum bundle subregions, including surgical targets previously evaluated for the treatment of bipolar disorder (cingulotomy and subgenual cingulate DBS targets). Cortical and subcortical ROIs of brain areas thought to be associated with bipolar disorder and described in animal tract-tracing models were created via FreeSurfer. The number of axonal projections from the cingulum bundle subregion ROIs to cortical/subcortical ROIs for each group was compared. RESULTS Significant differences were found across groups involving cingulum bundle and CSTC loops. Subjects in the RSP group had increased connections from rostral cingulum bundle to medial orbitofrontal cortex, which is part of the limbic CSTC loop, whereas subjects in the REF group had increased connectivity from rostral cingulum bundle to thalamus. Additionally, compared to HCs, both RSP and REF subjects had decreased cingulum bundle dorsal connectivity (dorsal anterior/posterior cingulate, dorsomedial/lateral frontal cortex) and increased cingulum bundle ventral connectivity (subgenual cingulate, frontal pole, lateral orbitofrontal cortex) involving limbic and associative CSTC loops. CONCLUSIONS Findings demonstrate that bipolar treatment responsivity may be associated with significant differences in cingulum bundle connectivity in relation to CSTC loops, which may help identify a surgical target for bipolar disorder treatment via DBS in the future.

Published
2022

147. Essential data dimensions for prospective international data collection in older age bipolar disorder ( OABD ): Recommendations from the GAGE‐BD group

Author

Lavin, Paola, primary, Rej, Soham, additional, Olagunju, Andrew T., additional, Teixeira, Antonio L., additional, Dols, Annemieke, additional, Alda, Martin, additional, Almeida, Osvaldo P., additional, Altinbas, Kursat, additional, Balanzá‐Martínez, Vicent, additional, Barbosa, Izabela G., additional, Blumberg, Hilary P., additional, Briggs, Farren, additional, Calkin, Cynthia, additional, Cassidy, Kristin, additional, Forester, Brent P., additional, Forlenza, Orestes V., additional, Hajek, Tomas, additional, Haarman, Barthomeus C. M., additional, Jimenez, Esther, additional, Lafer, Beny, additional, Mulsant, Benoit, additional, Oluwaniyi, Stephen O., additional, Patrick, Regan, additional, Radua, Joaquim, additional, Schouws, Sigfried, additional, Sekhon, Harmehr, additional, Simhandl, Christian, additional, Soares, Jair C., additional, Tsai, Shang‐Ying, additional, Vieta, Eduard, additional, Villa, Luca M., additional, Sajatovic, Martha, additional, and Eyler, Lisa T., additional

Published
2023
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149. Poor Seizure Control Among Children Attending a Tertiary Hospital in South Western Uganda – A Retrospective Study

Author

Namusisi, Jane, primary, Kyoyagala, Stella, additional, Nantongo, Josephine, additional, Kyewalyanga, Mike, additional, Sabiiti, Stephen, additional, Murorunkwere, Angelique, additional, Najjuma, Josephine Nambi, additional, Nakibuuka, Jane, additional, Kaddumukasa, Mark, additional, Sajatovic, Martha, additional, and Kalubi, Peter, additional

Published
2023
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