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Video Video 1 Technical feasibility, safety, and efficacy of a novel endoscopic approach to treating weight regain after open vertical-banded gastroplasty using an endoscopic suturing device.

Cascading failures significantly contribute to the total demand not served of safety-relevant blackout events occurring in transmission systems worldwide. Cascades in the network can be triggered by multiple, concurrent contingencies that originate from different types of external (e.g. extreme weather events) and internal (e.g. random component failures) hazards. Given the stochastic nature of the latter, probabilistic approaches are required to assess the vulnerability of transmission systems to such threats, complementing the existing deterministic approaches in the security assessment of transmission systems. Framed within this research direction, the present project aims at providing a probabilistic modelling framework to comprehensively assess the risk profile of a given transmission system subject to multiple external and internal hazards. The framework will combine established PRA tools (e.g. hazard maps, fragility curves) with state-of-art quantitative models (e.g. Bayesian inference, machine learning algorithms) to estimate data-driven failure probability values and uncertainty bounds for system components, and assess the impacts of component outages on the system via cascading failure analysis. The proposed framework will allow for in-depth analyses of the security of supply of transmission systems, supporting operators in the identification of system vulnerabilities and in the prioritization of risk mitigation strategies to minimize the consequences of accidental events for the connected end-users., Book of Extended Abstracts for the 32nd European Safety and Reliability Conference (ESREL 2022), ISBN:978-981-18-5183-4

Background: To assess the event rates of myocarditis detected by Cardiac Magnetic Resonance (CMR) in athletes who recovered from COVID-19. Methods: A systematic literature search was performed to identify studies reporting abnormal CMR findings in athletes who recovered from COVID-19. Secondary analyses were performed considering increased serum high sensitivity troponin (hs-Tn) levels and electrocardiographic (ECG) and echocardiographic (ECHO) abnormalities. Results: In total, 7988 athletes from 15 studies were included in the analysis. The pooled event rate of myocarditis was 1% (CI 1–2%), reaching 4% in the sub-group analysis. In addition, heterogeneity was observed (I2 43.8%). The pooled event rates of elevated serum hs-Tn levels, abnormal ECG and ECHO findings were 2% (CI 1–5%), 3% (CI 1–10%) and 2% (CI 1–6%), respectively. ECG, ECHO and serum hs-Tn level abnormalities did not show any correlation with myocarditis. Conclusions: The prevalence of COVID-19-related myocarditis in the athletic population ranges from 1 to 4%. Even if the event rate is quite low, current screening protocols are helpful tools for a safe return to play to properly address CMR studies. Trial registration: the study protocol was registered in the PROSPERO database (registration number: CRD42022300819).

Additional file 1: Figure S1. Rarefaction curves used to define the rarefaction threshold. Figure S1. shows box-plot of statistically different taxa between healthy and tumor samples. Table S1. lists the differences among data obtained in different cohorts of patients in several studies by different Authors for results comparison.

Gastric duplication cysts are rare congenital malformation with a potential neoplastic progression and they may represent a challenge in differential diagnosis with exophytic pancreatic cyst neoplasm. We describe a case of a 38-year old man, complaining of recurrent epigastric pain due to a large abdominal mass, referred to our Hospital for EUS evaluation. Differential diagnosis was between gastric duplication cyst and exophytic pancreatic cyst because of FNA pointed out amylase 1280 UI/L and CEA 593.33 ng/mL. Despite antibiotic prophylaxis, an overinfection of the lesion occurred after the FNA, likely due to the technical failure to drain the cyst completely. Afterwards, the patient was referred to surgery and the pathologist confirmed the diagnosis of gastric duplication cyst. In this setting, EUS procedure has gained a leading play, complementary to traditional imaging tests, although its role has been not yet standardized in the reported literature. Here, we describe and discuss our demanding case, and we propose an algorithm to simplify and standardize the diagnostic workup.

Congenital and acquired diseases of coronary arteries are frequent causes of sudden cardiac death (SCD) in recreational and competitive sportsmen. Coronary atherosclerosis is responsible for the vast majority of SCD in middle-aged and older athletes, while the anomalous origin of a coronary artery from the “wrong” sinus of Valsalva is one of the most frequent causes in the younger ones. Regardless of the type of disease and mechanisms involved, SCD is usually the result of exercise-induced myocardial ischemia.

Background: The usefulness of adapted small-side games (SSGs) in improving cardiac function in subjects with T2DM is still debated. Here we evaluated the effects of 18weeks Indoor Muscular Activation training (6 wks; IMA) followed by adapted SSGs football training (12wks) on cardiac function, muscular fitness, Body Composition and adiponectin expression in sedentary T2DM volunteers. Methods: 6 T2DM patients underwent IMA protocol of 6 wks, 2/wk followed by 12 wks SSGs (5vs5; once a wk) training. Glucose, lipid profile and serum homocysteine concentration, Body Composition (BC), bone mineral density (DEXA), were determined at baseline and after 18wks (IMA+SSGs). VO2max and muscular fitness were recorded at baseline and after IMA (6wks) and SSGs (12 wks), respectively. Results: No significant differences were found for VO2max and muscular fitness after 6wks of IMA. After 18wks (6 wks IMA+ 12 wks SSGs) of training, significant improvements were found in the following parameters: work capacity, VO2peack, Ventilation (VEpeack), breathing reserve consumption and oxygen uptake efficiency (OUES) (p

We introduce a novel measure for the quantum property of nonstabilizerness - commonly known as "magic" - by considering the R\'enyi entropy of the probability distribution associated to a pure quantum state given by the square of the expectation value of Pauli strings in that state. We show that this is a good measure of nonstabilizerness from the point of view of resource theory and show bounds with other known measures. The stabilizer R\'enyi entropy has the advantage of being easily computable because it does not need a minimization procedure. We present a protocol for an experimental measurement by randomized measurements. We show that the nonstabilizerness is intimately connected to out-of-time-order correlation functions and that maximal levels of nonstabilizerness are necessary for quantum chaos.

In this work, we provide an analytical proof of the robustness of topological entanglement under a model of random local perturbations. We define a notion of average topological subsystem purity and show that, in the context of quantum double models, this quantity does detect topological order and is robust under the action of a random quantum circuit of shallow depth., Added new references

We performed a pilot study to evaluate the use of MRI delta texture analysis (D-TA) as a methodological item able to predict the frequency of complete pathological responses and, consequently, the outcome of patients with locally advanced rectal cancer addressed to neoadjuvant chemoradiotherapy (C-RT) and subsequently, to radical surgery. In particular, we carried out a retrospective analysis including 100 patients with locally advanced rectal adenocarcinoma who received C-RT and then radical surgery in three different oncological institutions between January 2013 and December 2019. Our experimental design was focused on the evaluation of the gross tumor volume (GTV) at baseline and after C-RT by means of MRI, which was contoured on T2, DWI, and ADC sequences. Multiple texture parameters were extracted by using a LifeX Software, while D-TA was calculated as percentage of variations in the two time points. Both univariate and multivariate analysis (logistic regression) were, therefore, carried out in order to correlate the above-mentioned TA parameters with the frequency of pathological responses in the examined patients’ population focusing on the detection of complete pathological response (pCR, with no viable cancer cells: TRG 1) as main statistical endpoint. ROC curves were performed on three different datasets considering that on the 21 patients, only 21% achieved an actual pCR. In our training dataset series, pCR frequency significantly correlated with ADC GLCM-Entropy only, when univariate and binary logistic analysis were performed (AUC for pCR was 0.87). A confirmative binary logistic regression analysis was then repeated in the two remaining validation datasets (AUC for pCR was 0.92 and 0.88, respectively). Overall, these results support the hypothesis that D-TA may have a significant predictive value in detecting the occurrence of pCR in our patient series. If confirmed in prospective and multicenter trials, these results may have a critical role in the selection of patients with locally advanced rectal cancer who may benefit form radical surgery after neoadjuvant chemoradiotherapy.

Since 1989, SIC Sport and a FMSI, in partnership with leading Italian Cardiological Scientific Associations (ANCE, ANMCO and SIC) have produced Cardiological Guidelines for Completive Sports Eligibility for athletes with heart disease (COCIS -- 1989, 1995, 2003, 2009 and 2017). The English version of the Italian Cardiological Guidelines for Competitive Sports Eligibility for athletes with heart disease was published in 2013 in this Journal. This publication is an update with respect to the document previously published in English in 2013. It includes the principal innovations that have emerged over recent years, and is divided into five main chapters: arrhythmias, ion channel disorders, congenital heart diseases, acquired valve diseases, cardiomyopathies, myocarditis and pericarditis and ischemic heart disease. Wherever no new data have been introduced with respect to the 2013 publication, please refer to the previous version. This document is intended to complement recent European and American guidelines but an important difference should be noted. The European and American guidelines indicate good practice for people engaging in physical activity at various levels, not only at the competitive level. In contrast, the COCIS guidelines refer specifically to competitive athletes in various sports including those with high cardiovascular stress. This explains why Italian guidelines are more restrictive than European and USA ones. COCIS guidelines address 'sports doctors' who, in Italy, must certify fitness to participate in competitive sports. In Italy, this certificate is essential for participating in any competition.

Background The COVID-19 pandemic with the stay-at-home orders and lockdown has dramatically forced athletes to stop team training and competitions, causing deep changes in habits and lifestyle. Aim of this study was to evaluate in a retrospective single center study the cardiovascular (CV) health and fitness of elite football player after COVID-19 lockdown in Italy and to compare such findings with the 2019 off-season period, in order to identify potential differences in the CV features and outcomes. Methods All 29 professional Football players of the first male team were enrolled before resuming training and competition after COVID-19 lockdown and underwent several exams including physical examination, resting and stress electrocardiography (ECG), echocardiography, spirometry and blood tests. Results Median age was 27 years (23; 31), with no athlete being COVID-19 positive at the time of the evaluation. In comparison with the usual off-season 2-month detraining, significant differences were found for left ventricular (LV) mass (189g [172; 212] vs. 181g [167; 206], p=0.024) and LV mass index for body surface area (94g/m2 [85; 104] vs 88g/m2 [79.5; 101.5], p=0.017), while LV mass/fat free mass remained unchanged (2.8 g/Kg [2.6; 2.9] vs 2.9 g/Kg [2.6; 3.2], p=0.222). Respiratory function and metabolic profile were improved, while no significant changes were found in ECG findings, at rest and during exercise. Conclusions Prolonged abstinence from training and competitions induced by lockdown elicited significant changes in comparison with off-season in parameters ascribable to detraining, as the changes in LV mass, in respiratory function and in metabolic profile.