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2,386 results on '"Schirmacher P"'

101. DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics

Author

Kommoss, Felix K. F., Stichel, Damian, Schrimpf, Daniel, Kriegsmann, Mark, Tessier-Cloutier, Basile, Talhouk, Aline, McAlpine, Jessica N., Chang, Kenneth T. E., Sturm, Dominik, Pfister, Stefan M., Romero-Pérez, Laura, Kirchner, Thomas, Grünewald, Thomas G. P., Buslei, Rolf, Sinn, Hans-Peter, Mechtersheimer, Gunhild, Schirmacher, Peter, Schmidt, Dietmar, Lehr, Hans-Anton, Sahm, Felix, Huntsman, David G., Gilks, C. Blake, Kommoss, Friedrich, von Deimling, Andreas, and Koelsche, Christian

Published
2020
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102. Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

Author

Tschaharganeh, Darjus Felix, Chen, Xin, Latzko, Philipp, Malz, Mona, Gaida, Matthias Martin, Felix, Klaus, Ladu, Sara, Singer, Stephan, Pinna, Federico, Gretz, Norbert, Sticht, Carsten, Tomasi, Maria Lauda, Delogu, Salvatore, Evert, Matthias, Fan, Biao, Ribback, Silvia, Jiang, Lijie, Brozzetti, Stefania, Bergmann, Frank, Dombrowski, Frank, Schirmacher, Peter, Calvisi, Diego Francesco, and Breuhahn, Kai

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nutrition and Dietetics, Rare Diseases, Genetics, Cancer, Digestive Diseases, Colo-Rectal Cancer, Liver Disease, Liver Cancer, Aetiology, 2.1 Biological and endogenous factors, Adaptor Proteins, Signal Transducing, Animals, Calcium-Binding Proteins, Carcinoma, Hepatocellular, Cell Cycle Proteins, Cell Line, Tumor, Cell Proliferation, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Hepatocytes, Humans, Intercellular Signaling Peptides and Proteins, Jagged-1 Protein, Liver Neoplasms, Membrane Proteins, Mice, Muscle Proteins, Phosphoproteins, Receptors, Notch, Serrate-Jagged Proteins, TEA Domain Transcription Factors, Transcription Factors, Up-Regulation, YAP-Signaling Proteins, Transcriptional Regulators, Colorectal Cancer, Pancreatic Cancer, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsCancer cells often lose contact inhibition to undergo anchorage-independent proliferation and become resistant to apoptosis by inactivating the Hippo signaling pathway, resulting in activation of the transcriptional co-activator yes-associated protein (YAP). However, the oncogenic mechanisms of YAP activity are unclear.MethodsBy using cross-species analysis of expression data, the Notch ligand Jagged-1 (Jag-1) was identified as a downstream target of YAP in hepatocytes and hepatocellular carcinoma (HCC) cells. We analyzed the functions of YAP in HCC cells via overexpression and RNA silencing experiments. We used transgenic mice that overexpressed a constitutively activated form of YAP (YAP(S127A)), and measured protein levels in HCC, colorectal and pancreatic tumor samples from patients.ResultsHuman HCC cell lines and mouse hepatocytes that overexpress YAP(S127A) up-regulated Jag-1, leading to activation of the Notch pathway and increased proliferation. Induction of Jag-1, activation of Notch, and cell proliferation required binding of YAP to its transcriptional partner TEA domain family member 4 (TEAD4); TEAD4 binding required the Mst1/2 but not β-catenin signaling. Levels of YAP correlated with Jag-1 expression and Notch signaling in human tumor samples and correlated with shorter survival times of patients with HCC or colorectal cancer.ConclusionsThe transcriptional regulator YAP up-regulates Jag-1 to activate Notch signaling in HCC cells and mouse hepatocytes. YAP-dependent activity of Jag-1 and Notch correlate in human HCC and colorectal tumor samples with patient survival times, suggesting the use of YAP and Notch inhibitors as therapeutics for gastrointestinal cancer. Transcript profiling: microarray information was deposited at the Gene Expression Omnibus database (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?token=jxepvsumwosqkve&acc=GSE35004).

Published
2013

105. Multicentric analytical comparability study of programmed death-ligand 1 expression on tumor-infiltrating immune cells and tumor cells in urothelial bladder cancer using four clinically developed immunohistochemistry assays

Author

Schwamborn, Kristina, Ammann, Johannes U, Knüchel, Ruth, Hartmann, Arndt, Baretton, Gustavo, Lasitschka, Felix, Schirmacher, Peter, Braunschweig, Till, Tauber, Robert, Erlmeier, Franziska, Hieke-Schulz, Stefanie, and Weichert, Wilko

Published
2019
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107. The BRCA2 mutation status shapes the immune phenotype of prostate cancer

Author

Jenzer, Maximilian, Keß, Peter, Nientiedt, Cathleen, Endris, Volker, Kippenberger, Maximilian, Leichsenring, Jonas, Stögbauer, Fabian, Haimes, Josh, Mishkin, Skyler, Kudlow, Brian, Kaczorowski, Adam, Zschäbitz, Stefanie, Volckmar, Anna-Lena, Sültmann, Holger, Jäger, Dirk, Duensing, Anette, Schirmacher, Peter, Hohenfellner, Markus, Grüllich, Carsten, Stenzinger, Albrecht, and Duensing, Stefan

Published
2019
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114. Electronic correlation effects and the Coulomb gap at finite temperature

Author

Sandow, B., Gloos, K., Rentzsch, R., Ionov, A. N., and Schirmacher, W.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We have investigated the effect of the long-range Coulomb interaction on the one-particle excitation spectrum of n-type Germanium, using tunneling spectroscopy on mechanically controllable break junctions. The tunnel conductance was measured as a function of energy and temperature. At low temperatures, the spectra reveal a minimum at zero bias voltage due to the Coulomb gap. In the temperature range above 1 K the Coulomb gap is filled by thermal excitations. This behavior is reflected in the temperature dependence of the variable-range hopping resitivity measured on the same samples: Up to a few degrees Kelvin the Efros-Shkovskii ln$R \propto T^{-1/2}$ law is obeyed, whereas at higher temperatures deviations from this law are observed, indicating a cross-over to Mott's ln$R \propto T^{-1/4}$ law. The mechanism of this cross-over is different from that considered previously in the literature., Comment: 3 pages, 3 figures

Published
2000
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115. Harmonic Vibrational Excitations in Disordered Solids and the 'Boson Peak'

Author

Schirmacher, W., Diezemann, G, and Ganter, C.

Subjects
Condensed Matter
Abstract

We consider a system of coupled classical harmonic oscillators with spatially fluctuating nearest-neighbor force constants on a simple cubic lattice. The model is solved both by numerically diagonalizing the Hamiltonian and by applying the single-bond coherent potential approximation. The results for the density of states $g(\omega)$ are in excellent agreement with each other. As the degree of disorder is increased the system becomes unstable due to the presence of negative force constants. If the system is near the borderline of stability a low-frequency peak appears in the reduced density of states $g(\omega)/\omega^2$ as a precursor of the instability. We argue that this peak is the analogon of the "boson peak", observed in structural glasses. By means of the level distance statistics we show that the peak is not associated with localized states.

Published
1998
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118. Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer

Author

Scherr, Anna-Lena, Mock, Andreas, Gdynia, Georg, Schmitt, Nathalie, Heilig, Christoph E., Korell, Felix, Rhadakrishnan, Praveen, Hoffmeister, Paula, Metzeler, Klaus H., Schulze-Osthoff, Klaus, Illert, Anna L., Boerries, Melanie, Trojan, Jörg, Waidmann, Oliver, Falkenhorst, Johanna, Siveke, Jens, Jost, Philipp J., Bitzer, Michael, Malek, Nisar P., Vecchione, Loredana, Jelas, Ivan, Brors, Benedikt, Glimm, Hanno, Stenzinger, Albrecht, Grekova, Svetlana P., Gehrig, Tobias, Schulze-Bergkamen, Henning, Jäger, Dirk, Schirmacher, Peter, Heikenwalder, Mathias, Goeppert, Benjamin, Schneider, Martin, Fröhling, Stefan, and Köhler, Bruno C.

Published
2020
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119. Mutant KIT as imatinib-sensitive target in metastatic sinonasal carcinoma

Author

Dieter, S.M., Heining, C., Agaimy, A., Huebschmann, D., Bonekamp, D., Hutter, B., Ehrenberg, K.R., Fröhlich, M., Schlesner, M., Scholl, C., Schlemmer, H.-P., Wolf, S., Mavratzas, A., Jung, C.S., Gröschel, S., von Kalle, C., Eils, R., Brors, B., Penzel, R., Kriegsmann, M., Reuss, D.E., Schirmacher, P., Stenzinger, A., Federspil, P.A., Weichert, W., Glimm, H., and Fröhling, S.

Published
2017
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130. Multicenter validation of cancer gene panel-based next-generation sequencing for translational research and molecular diagnostics

Author

Hirsch, B., Endris, V., Lassmann, S., Weichert, W., Pfarr, N., Schirmacher, P., Kovaleva, V., Werner, M., Bonzheim, I., Fend, F., Sperveslage, J., Kaulich, K., Zacher, A., Reifenberger, G., Köhrer, K., Stepanow, S., Lerke, S., Mayr, T., Aust, D. E., Baretton, G., Weidner, S., Jung, A., Kirchner, T., Hansmann, M. L., Burbat, L., von der Wall, E., Dietel, M., and Hummel, M.

Published
2018
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135. HER2 gene (ERBB2) amplification is a rare event in non-liver-fluke associated cholangiocarcinogenesis

Author

Albrecht, Thomas, Rausch, Melina, Rössler, Stephanie, Albrecht, Michael, Braun, Jana Dorothea, Geissler, Veronika, Mehrabi, Arianeb, Vogel, Monika Nadja, Pathil-Warth, Anita, Mechtersheimer, Gunhild, Renner, Marcus, Rupp, Christian, Weiss, Karl Heinz, Busch, Elena, Köhler, Bruno, Springfeld, Christoph, Schirmacher, Peter, and Goeppert, Benjamin

Published
2019
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137. Nucleoporin Nup155 is part of the p53 network in liver cancer

Author

Holzer, Kerstin, Ori, Alessandro, Cooke, Amy, Dauch, Daniel, Drucker, Elisabeth, Riemenschneider, Philip, Andres-Pons, Amparo, DiGuilio, Amanda L., Mackmull, Marie-Therese, Baßler, Jochen, Roessler, Stephanie, Breuhahn, Kai, Zender, Lars, Glavy, Joseph S., Dombrowski, Frank, Hurt, Ed, Schirmacher, Peter, Beck, Martin, and Singer, Stephan

Published
2019
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138. Low frequency of mismatch repair deficiency in gallbladder cancer

Author

Goeppert, Benjamin, Roessler, Stephanie, Renner, Marcus, Loeffler, Moritz, Singer, Stephan, Rausch, Melina, Albrecht, Thomas, Mehrabi, Arianeb, Vogel, Monika Nadja, Pathil, Anita, Czink, Elena, Köhler, Bruno, Springfeld, Christoph, Rupp, Christian, Weiss, Karl Heinz, Schirmacher, Peter, von Knebel Doeberitz, Magnus, and Kloor, Matthias

Published
2019
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139. Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p

Author

Goeppert, Benjamin, Truckenmueller, Felicia, Ori, Alessandro, Fritz, Valerie, Albrecht, Thomas, Fraas, Angelika, Scherer, Dominique, Silos, Rosa González, Sticht, Carsten, Gretz, Norbert, Mehrabi, Arianeb, Bewerunge-Hudler, Melanie, Pusch, Stefan, Bermejo, Justo Lorenzo, Dietrich, Peter, Schirmacher, Peter, Renner, Marcus, and Roessler, Stephanie

Published
2019
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140. Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma

Author

Goeppert, Benjamin, Renner, Marcus, Singer, Stephan, Albrecht, Thomas, Zhang, Qiangnu, Mehrabi, Arianeb, Pathil, Anita, Springfeld, Christoph, Köhler, Bruno, Rupp, Christian, Weiss, Karl Heinz, Kühl, Anja A., Arsenic, Ruza, Pape, Ulrich Frank, Vogel, Arndt, Schirmacher, Peter, Roessler, Stephanie, and Utku, Nalân

Published
2019
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141. DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy

Author

Tawk, B., Rein, K., Schwager, C., Knoll, M., Wirkner, U., Hörner-Rieber, J., Liermann, J., Kurth, I., Balermpas, P., Rödel, C., Linge, A., Löck, S., Lohaus, F., Tinhofer, I., (0000-0003-1776-9556) Krause, M., Stuschke, M., Ligia Grosu, A., Zips, D., Combs, S. E., Belka, C., Stenzinger, A., Herold-Mende, C., Baumann, M., Schirmacher, P., Debus, J., Abdollahi, A., Tawk, B., Rein, K., Schwager, C., Knoll, M., Wirkner, U., Hörner-Rieber, J., Liermann, J., Kurth, I., Balermpas, P., Rödel, C., Linge, A., Löck, S., Lohaus, F., Tinhofer, I., (0000-0003-1776-9556) Krause, M., Stuschke, M., Ligia Grosu, A., Zips, D., Combs, S. E., Belka, C., Stenzinger, A., Herold-Mende, C., Baumann, M., Schirmacher, P., Debus, J., and Abdollahi, A.

Abstract

Purpose: Tumor hypoxia is a paradigmatic negative prognosticator of treatment resistance in head and neck squamous cell carcinoma (HNSCC). The lack of robust and reliable hypoxia classifiers limits the adaptation of stratified therapies. We hypothesized that the tumor DNA methylation landscape might indicate epigenetic reprogramming induced by chronic intratumoral hypoxia. Experimental Design: A DNA-methylome–based tumor hypoxia classifier (Hypoxia-M) was trained in the TCGA (The Cancer Genome Atlas)-HNSCC cohort based on matched assignments using gene expression–based signatures of hypoxia (Hypoxia-GES). Hypoxia-M was validated in a multicenter DKTK-ROG trial consisting of human papillomavirus (HPV)–negative patients with HNSCC treated with primary radiochemotherapy (RCHT). Results: Although hypoxia-GES failed to stratify patients in the DKTK-ROG, Hypoxia-M was independently prognostic for local recurrence (HR, 4.3; P ¼0.001) and overall survival (HR, 2.34; P ¼ 0.03) but not distant metastasis after RCHT in both cohorts. Hypoxia-M status was inversely associated with CD8 T-cell infiltration in both cohorts. Hypoxia-M was further prognostic in the TCGA-PanCancer cohort (HR, 1.83; P ¼0.04), underscoring the breadth of this classifier for predicting tumor hypoxia status. Conclusions: Our findings highlight an unexplored avenue for DNA methylation–based classifiers as biomarkers of tumoral hypoxia for identifying high-risk features in patients with HNSCC tumors.

Published
2023

144. EGFR T790M mutation testing of non-small cell lung cancer tissue and blood samples artificially spiked with circulating cell-free tumor DNA: results of a round robin trial

Author

Fassunke, Jana, Ihle, Michaela Angelika, Lenze, Dido, Lehmann, Annika, Hummel, Michael, Vollbrecht, Claudia, Penzel, Roland, Volckmar, Anna-Lena, Stenzinger, Albrecht, Endris, Volker, Jung, Andreas, Lehmann, Ulrich, Zeugner, Silke, Baretton, Gustavo, Kreipe, Hans, Schirmacher, Peter, Kirchner, Thomas, Dietel, Manfred, Büttner, Reinhard, and Merkelbach-Bruse, Sabine

Published
2017
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