117 results on '"Schweitzer, Isaac"'
Search Results
102. Psychological Reactions and Processes Following Replantation Surgery.
- Author
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Schweitzer, Isaac, Rosenbaum, Maj-Britt, Sharzer, Leonard A., and Strauch, Berish
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- 1985
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103. Postrhytidectomy Psychosis.
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Schweitzer, Isaac and Hirschfeld, Joseph J.
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- 1984
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104. Is diazepam an antidepressant?
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Tiller, John, Schweitzer, Isaac, Maguire, Kay, Davies, Brian, Tiller, J W, Schweitzer, I, Maguire, K P, and Davis, B
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DIAZEPAM ,THERAPEUTICS ,MENTAL depression ,MOCLOBEMIDE ,ANTIDEPRESSANTS ,BENZODIAZEPINES ,MUSCLE relaxants ,MONOAMINE oxidase inhibitors ,AROUSAL (Physiology) ,BENZAMIDE ,CLINICAL trials ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,PSYCHOLOGICAL tests ,RESEARCH ,EVALUATION research ,RANDOMIZED controlled trials ,ANXIETY disorders ,PSYCHOLOGY - Abstract
In double-blind sequential study, diazepam was compared with the proven antidepressant moclobemide, in patients with atypical depression. Both agents significantly improved depression ratings over eight weeks of treatment. Diazepam was a significantly better antidepressant than moclobemide at four week, although not at eight weeks. All patients ceased diazepam within one year and none reported withdrawal reactions. These data suggest the need to reconsider that benzodiazepines may be antidepressants and to study their possible antidepressant actions. [ABSTRACT FROM AUTHOR]
- Published
- 1989
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105. The Psychiatric Assessment of the Patient Requesting Facial Surgery
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Schweitzer, Isaac
- Abstract
Recent years have witnessed an increasing demand for cosmetic or reconstructive facial surgery. This paper addresses the pre-operative psychiatric assessment of the patient requesting facial surgery. Most patients adjust well to surgery and appreciate and accept the outcome. The psychiatrist who helps to screen difficult cases needs specific skills and must understand the body image issues involved. The psychiatrist needs to evaluate the patient's motivations, expectations and understanding of the risks and implications of surgery. Potential problem patients are described, including the minimal defect patient, the patient with secondary gain from the deformity, the older patient, the patient in crisis, the polysurgical patient, the paranoid patient, the schizophrenic patient, and the male patient. Guidelines for evaluating the patient need to be applied flexibly. The psychiatrist must communicate with the surgeon to appreciate clearly the concerns the surgeon has about each patient.
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- 1989
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106. Liaison Consultation Psychiatry with Patients who Have Replantation Surgery to the Upper Limb
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Schweitzer, Isaac, Rosenbaum, Maj-Britt, Sharzer, Leonard A., and Strauch, Berish
- Abstract
Thirty-eight patients who had replantation surgery to the upper limb were studied and findings, case vignettes and specific liaison-consultation issues are presented. The assessment of the patient for pre-existing psychopathology, such as drug and alcohol abuse and personality abnormalities, is emphasised; the possibility of the amputation having been a deliberate, self-inflicted act is noted; and the roles of pre-accident stress and emotional conflict are discussed. Data concerning adverse post-operative emotional reactions are presented and body-image changes, including the disruption to body integrity and the reintegration of the bodily part, are described. The psychological aspects of replantation surgery are compared to other forms of surgery, in particular amputation and renal transplantation.
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- 1986
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107. A review of the use of augmentation therapy for the treatment of resistant depression: implications for the clinician
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Johnson, Gordon, Schweitzer, Isaac, and Tuckwell, Virginia
- Abstract
Objective: To critically review the literature on augmentation therapy in resistant depression in order to assist the clinician to make a reasoned choice. Augmentation therapy is defined as the addition of a second agent to an existing antidepressant regimen with the aim of achieving improved clinical response.Method: The available literature which related specifically to currently popular augmentation strategies in treatment resistant depression for the past 20 years was examined. The scientific evidence supporting the efficacy of these regimens and their safety was reviewed.Results: Considerable research on lithium augmentation has been undertaken, and on triiodothyronine augmentation to a lesser degree. A number of other drugs have been trialled as augmentation agents with claims of success; however, most of the evidence supporting these agents is anecdotal and in the form of case reports. There are very few well-performed double-blind placebo-controlled studies of augmentation therapy.Conclusions: Because of possible complex pharmacodynamic and pharmacokinetic interactions, augmentation therapy is not without its potential complications. Lithium augmentation of tricyclic antidepressants can be recommended as a safe and effective strategy and there is a body of scientific evidence supporting the addition of T3 as an effective augmentation agent. Recent research with pindolol augmentation of selective serotonin re-uptake inhibitors (SSRIs) is encouraging, but these findings require replication. There is no empirical evidence supporting buspirone, carbamazepine, sodium valproate, methylphenidate or amphetamine as effective augmentation agents, or that adding a tricyclic to a SSRI has usefulness in relieving depressive symptoms. There is a need for considerable research in this area, with more prospective well-controlled placebo studies.
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- 1997
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108. A sequential double-blind controlled study of moclobemide and diazepam in patients with atypical depression
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Tiller, John, primary, Schweitzer, Isaac, additional, Maguire, Kay, additional, and Davies, Brian, additional
- Published
- 1989
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109. Psychiatric aspects of replantation surgery
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Schweitzer, Isaac, primary and Rosenbaum, Maj-Britt, additional
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- 1982
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110. Book reviews.
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James, Norman, Sachdev, Perminder, Schweitzer, Isaac, Goldney, Robert D., Norman, Trevor R., Pargiter, R.A., Rushford, Nola, Beatson, Josephine, Morse, Carol, England, Richard, and Leonard, David
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- TROUBLESOME Disguises: Underdiagnosed Psychiatric Syndromes (Book), ORGANIC Psychiatry (Book), MOOD Disorders (Book)
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Reviews 11 books related to psychiatry. 'Troublesome Disguises: Underdiagnosed Psychiatric Syndromes,' edited by Dinesh Bhugra and Alistair Munro; 'Organic Psychiatry: The Psychological Sequences of Cerebral Disorder,' 3rd ed., by William Alwyn Lishman; 'Mood Disorders: Systematic Medication Management. Modern Problems of Pharmacopsychiatry,' Vol. 25, edited by A.J.Rush.
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- 1999
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111. Kava: a comprehensive review of efficacy, safety, and psychopharmacology.
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Sarris, Jerome, LaPorte, Emma, and Schweitzer, Isaac
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ANALYSIS of variance , *CLINICAL trials , *INFORMATION storage & retrieval systems , *MEDICAL databases , *PSYCHOLOGY information storage & retrieval systems , *KAVA plant , *MEDLINE , *ONLINE information services - Abstract
Overview: Kava ( Piper methysticum) is a South Pacific psychotropic plant medicine that has anxiolytic activity. This effect is achieved from modulation of GABA activity via alteration of lipid membrane structure and sodium channel function, monoamine oxidase B inhibition, and noradrenaline and dopamine re-uptake inhibition. Kava is available over the counter in jurisdictions such as the USA, Australia and New Zealand. Due to this, a review of efficacy, safety and clinical recommendations is advised. Objective: To conduct a comprehensive review of kava, in respect to efficacy, psychopharmacology, and safety, and to provide clinical recommendations for use in psychiatry to treat generalized anxiety disorder (GAD). Methods: A review was conducted using the electronic databases MEDLINE, CINAHL, PsycINFO and the Cochrane Library during mid 2010 of search terms relating to kava and GAD. A subsequent forward search was conducted of key papers using Web of Science cited reference search. Results: The current weight of evidence supports the use of kava in treatment of anxiety with a significant result occurring in four out of six studies reviewed (mean Cohen's d = 1.1). Safety issues should however be considered. Use of traditional water soluble extracts of the rhizome (root) of appropriate kava cultivars is advised, in addition to avoidance of use with alcohol and caution with other psychotropic medications. Avoidance of high doses if driving or operating heavy machinery should be mandatory. For regular users routine liver function tests are advised. Conclusions: While current evidence supports kava for generalized anxiety, more studies are required to assess comparative efficacy and safety (on the liver, cognition, driving, and sexual effects) versus established pharmaceutical comparators. [ABSTRACT FROM AUTHOR]
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- 2011
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112. Mood disorders: systematic medication management. Modern problems of pharmacopsychiatry, Vol. 25.
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Schweitzer, Isaac
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AFFECTIVE disorders , *NONFICTION - Abstract
The article reviews the book "Mood Disorders: Systematic Medication Management: Modern Problems of Pharmacopsychiatry," Volume 25, edited by A.J. Rush.
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- 1999
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113. A new early cognitive screening measure to detect cognitive side-effects of electroconvulsive therapy?
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Martin, Donel M., Katalinic, Natalie, Ingram, Anna, Schweitzer, Isaac, Smith, Deidre J., Hadzi-Pavlovic, Dusan, and Loo, Colleen K.
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COGNITIVE ability , *ELECTROCONVULSIVE therapy , *LONGITUDINAL method , *HOSPITAL admission & discharge , *HEALTH outcome assessment , *MULTIVARIATE analysis , *SAFETY - Abstract
Abstract: Cognitive side-effects from electroconvulsive therapy (ECT) can be distressing for patients and early detection may have an important role in guiding treatment decisions over the ECT course. This prospective study examined the utility of an early cognitive screening battery for predicting cognitive side-effects which develop later in the ECT course. The screening battery, together with the Mini Mental Status Examination (MMSE), was administered to 123 patients at baseline and after 3 ECT treatments. A more detailed cognitive battery was administered at baseline, after six treatments (post ECT 6) and after the last ECT treatment (post treatment) to assess cognitive side-effects across several domains: global cognition, anterograde memory, executive function, speed and concentration, and retrograde memory. Multivariate analyses examined the predictive utility of change on items from the screening battery for later cognitive changes at post ECT 6 and post treatment. Results showed that changes on a combination of items from the screening battery were predictive of later cognitive changes at post treatment, particularly for anterograde memory (p < 0.01), after controlling for patient and treatment factors. Change on the MMSE predicted cognitive changes at post ECT 6 but not at post treatment. A scoring method for the new screening battery was tested for discriminative ability in a sub-sample of patients. This study provides preliminary evidence that a simple and easy-to-administer measure may potentially be used to help guide clinical treatment decisions to optimise efficacy and cognitive outcomes. Further development of this measure and validation in a more representative ECT clinical population is required. [Copyright &y& Elsevier]
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- 2013
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114. Blunted prolactin response to d-fenfluramine in post-stroke major depression
- Author
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Morris, Philip, Hopwood, Malcolm, Maguire, Kay, Norman, Trevor, and Schweitzer, Isaac
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PROLACTIN , *SEROTONIN , *BRAIN , *MAGNETIC resonance imaging - Abstract
Background: This study investigated whether patients suffering from post-stroke depressive disorder had a similar disturbance in central serotonergic function to that described in non-brain injured depressed patients. Methods: Twenty-three depressed patients (nine major, 14 minor) and 38 non-depressed patients were examined 4–8 weeks post-stroke with a structured interview, rating scales and MRI brain scans. Patients were administered 30 mg d-fenfluramine orally and plasma prolactin and d-fenfluramine concentrations were measured for 6 h post-dose. Results: The prolactin response was significantly blunted in major depression compared to minor depression and non-depressed patients as measured by both delta prolactin and area under the prolactin versus time curve. There was no significant relationship between prolactin response and lesion lateralization or any of the measured clinical characteristics. Limitations: The major limitation of the study is the relatively small number in each depressive group. Conclusions: Patients suffering from major depression in the post-stroke period have a blunted prolactin response to d-fenfluramine. This indicates a serotonergic abnormality consistent with that found in major depression where neurological disease is not present. [Copyright &y& Elsevier]
- Published
- 2003
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115. 'Help us, she's fading away': How to manage the patient with anorexia nervosa.
- Author
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Redston S, Tiller J, Schweitzer I, Keks N, Burrows G, Castle D, and Newton JR
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- Anorexia Nervosa psychology, Diagnostic and Statistical Manual of Mental Disorders, Early Diagnosis, Humans, Anorexia Nervosa diagnosis, Anorexia Nervosa therapy, General Practice
- Abstract
Background: Although integral to the early detection and treatment of anorexia nervosa, there is a paucity of clear guidance available for general practitioners (GPs). This paper attempts to bridge the gap between the specialist and generalist literature to assist the busy GP feel confident in identifying and managing these patients., Objective: On reading this article it is anticipated the GP will feel well equipped to screen for and provide ongoing treatment to patients who pre-sent with eating disorders, particularly anorexia nervosa. This paper provides guidance for the identification and ongoing management of patients with anorexia nervosa, and supporting their carers., Discussion: People affected by eating disorders, particularly anorexia nervosa, may deny having a problem, minimise their symptoms and resist treatment yet engage partially with their GP throughout the course of their illness. There are well-validated, quick screening tools that the non-specialist can use to identify patients at high risk of having an eating disorder.
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- 2014
116. Trade-off between the benefits of lithium treatment and the risk of chronic kidney disease.
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Adam WR, Schweitzer I, and Walker RG
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- Bipolar Disorder diagnosis, Bipolar Disorder psychology, Glomerular Filtration Rate drug effects, Humans, Kidney physiopathology, Patient Selection, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic physiopathology, Risk Assessment, Risk Factors, Treatment Outcome, Affect drug effects, Antimanic Agents adverse effects, Bipolar Disorder drug therapy, Kidney drug effects, Lithium Carbonate adverse effects, Renal Insufficiency, Chronic chemically induced
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- 2012
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117. Sexual side-effects of contemporary antidepressants: review.
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Schweitzer I, Maguire K, and Ng C
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- Depressive Disorder, Major complications, Humans, Randomized Controlled Trials as Topic, Sexual Behavior physiology, Sexual Dysfunction, Physiological complications, Sexual Dysfunction, Physiological therapy, Sexual Dysfunctions, Psychological complications, Sexual Dysfunctions, Psychological therapy, Antidepressive Agents adverse effects, Depressive Disorder, Major drug therapy, Selective Serotonin Reuptake Inhibitors adverse effects, Sexual Dysfunction, Physiological chemically induced, Sexual Dysfunctions, Psychological chemically induced
- Abstract
The aim of the present study was to review the sexual side-effects of contemporary antidepressants in Australia, comparing the selective serotonin re-uptake inhibitors (SSRIs) with venlafaxine, reboxetine, mirtazepine, duloxetine, bupropion, desvenlafaxine and agomelatine. Double-blind, randomized comparative studies of these antidepressants that included assessment of sexual dysfunction with validated rating scales in patients with major depressive disorder were identified from the literature using MEDLINE, EMBASE and PsychINFO databases. Bupropion and duloxetine caused significantly less sexual dysfunction than the SSRIs in short-term studies and reboxetine significantly less in both short- and longer term studies. Bupropion and agomelatine caused significantly less sexual dysfunction than venlafaxine. The evidence for mirtazepine having an advantage over the SSRIs is lacking and there are currently insufficient data for desvenlafaxine. Well-designed comparative studies of contemporary antidepressants with direct assessment of sexual side-effects as the primary outcome measure are scarce. Future studies should be randomized, double-blind, active controlled trials in sexually active subjects with major depressive disorder. There should be direct assessment of sexual function and depression using reliable, validated rating scales before and during treatment. Studies should assess treatment-emergent effects in patients with normal function and resolution of baseline dysfunction over treatment, in both the short and long term. Further research should compare available instruments for measuring sexual function, and include separate analyses of both remitters/non-remitters and male/female subjects.
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- 2009
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