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543 results on '"Shang, Luoran"'

144. Photothermal Responsive Microspheres‐Triggered Separable Microneedles for Versatile Drug Delivery.

Author

Fan, Lu, Zhang, Xiaoxuan, Nie, Min, Xu, Ye, Wang, Yuetong, Shang, Luoran, Zhao, Yongxiang, and Zhao, Yuanjin

Subjects
TRANSDERMAL medication, SYSTEMIC lupus erythematosus, MICROSPHERES, HYDROGELS, MICROFLUIDIC devices, SHEARING force
Abstract

Microneedle (MN) patches are promising stratagems for transdermal drug delivery owing to its minimal invasiveness and portability. Particularly, separable MN patches attract more attention for durable and long‐term drug delivery. Here, a new strategy for designing controllably separable MN patches by integrating photothermal responsive phase‐changing microspheres (MPs) into conical hydrogel MNs, is presented. Such MPs consist of near‐infrared (NIR)‐responsive black‐phosphorus (BP) and phase‐changing gelatin (GT), and are fabricated using a simple capillary microfluidic device. When the composite MN patch is exposed to NIR, the contained BP/GT MPs can transform light into heat, increase local temperature, turn into a liquid state, and form cavities in MNs, resulting in the convenient detachment of the backing plate and the needles by shear force. Subsequently, the embedded needles can sustainably release the drug. In addition to intelligently controlling the detachment of MNs, the BP/GT MPs can load macromolecular drugs and release them in response to NIR stimulation. Results further demonstrated that such controllably separable MN patch can effectively load and release two drugs to ameliorate disease progression for systemic lupus erythematosus treatment. These features indicate the practical values of controllably separable MN patches for versatile drug delivery and clinical applications. [ABSTRACT FROM AUTHOR]

Published
2022
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145. Cholesteric Cellulose Liquid Crystals with Multifunctional Structural Colors.

Author

Zhang, Zhuohao, Chen, Zhuoyue, Wang, Yu, Zhao, Yuanjin, and Shang, Luoran

Subjects
STRUCTURAL colors, CHOLESTERIC liquid crystals, POLYMER liquid crystals, MOLECULAR interactions, BIOMIMETIC materials, CONSTRUCTION materials, WEARABLE technology
Abstract

Structural coloration is an intriguing phenomenon that exists widely in living creatures. A genuine bionic design of artificial structural colors requires accommodating of molecular interactions that contribute to dynamic optical responses over various external stimuli. Novel composite cellulose cholesteric liquid crystals are reported with additional molecular interactions and dynamic regulations as a bionic prototype for biological structural coloration. It is found that the incorporation of polymer monomers increases the amount of hydrogen bonds, leading to a broader range of color tunability. In addition, the crosslinking of the polymer is accompanied by a time‐dependent structure alternation of the cellulose cholesteric liquid crystals, which offers a duration control of irradiation over the color. Based on these phenomena, a series of structural color materials is developed with dynamic photonic responsiveness and high‐resolution patterns; their utility in wearable sensors, graphic displays, and information encryption is demonstrated. It is believed that this study presents a next‐generation biomimetic photonic material design and applications for different areas. [ABSTRACT FROM AUTHOR]

Published
2022
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147. Droplet microfluidics-based biomedical microcarriers.

Author

Shao, Changmin, Chi, Junjie, Shang, Luoran, Fan, Qihui, and Ye, Fangfu

Subjects
EMULSIONS (Pharmacy), MICROFLUIDICS, CELL culture, REGENERATIVE medicine, PRODUCTION control, DRUG development, TISSUE engineering
Abstract

Droplet microfluidic technology provides a new platform for controllable generation of microdroplets and droplet-derived materials. In particular, because of the ability in high-throughput production and accurate control of the size, structure, and function of these materials, droplet microfluidics presents unique advantages in the preparation of functional microcarriers, i.e., microsized liquid containers or solid particles that serve as substrates of biomolecules or cells. These microcarriers could be extensively applied in the areas of cell culture, tissue engineering, and drug delivery. In this review, we focus on the fabrication of microcarriers from droplet microfluidics, and discuss their applications in the biomedical field. We start with the basic principle of droplet microfluidics, including droplet generation regimes and its control methods. We then introduce the fabrication of biomedical microcarriers based on single, double, and multiple emulsion droplets, and emphasize the various applications of microcarriers in biomedical field, especially in 3D cell culture, drug development and biomedical detection. Finally, we conclude this review by discussing the limitations and challenges of droplet microfluidics in preparing microcarriers. Because of its precise control and high throughput, droplet microfluidics has been employed to generate functional microcarriers, which have been widely used in the areas of drug development, tissue engineering, and regenerative medicine. This review is significant because it emphasizes recent progress in research on droplet microfluidics in the preparation and application of biomedical microcarriers. In addition, this review suggests research directions for the future development of biomedical microcarriers based on droplet microfluidics by presenting existing shortcomings and challenges. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2022
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149. Self-Healing Dynamic Hydrogel Microparticles with Structural Color for Wound Management

Author

Wang, Li, Ding, Xiaoya, Fan, Lu, Filppula, Anne M., Li, Qinyu, Zhang, Hongbo, Zhao, Yuanjin, and Shang, Luoran

Abstract

Derived from silica photonic crystals, inverse opal microspheres have a regularly connected porous structure and inherit structural color properties.Combined with the stable scaffold and the photothermal phase-transition of the secondary filling material, the inverse opal composite microspheres are endowed with self-healing properties and the ability for controllable drug release.Inverse opal microspheres were significantly treated for diabetic wound, via promoting tissue regeneration, collagen deposition and angiogenesis. Meanwhile, the release of drugs could be monitored by the structural color characteristic.

Published
2024
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