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5,262 results on '"Singh, Mandeep"'

101. Design and Comparison of Various Parameters of T-Shaped TFET of Variable Gate Lengths and Materials

Author

Upadhyay, Jyoti, Chaudhary, Tarun, Sunkaria, Ramesh Kumar, Singh, Mandeep, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Sharma, Devendra Kumar, editor, Peng, Sheng-Lung, editor, Sharma, Rohit, editor, and Jeon, Gwanggil, editor

Published
2024
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102. A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease

Author

Young, Clara, Singh, Mandeep, Jackson, Katherine J.L., Field, Matt A., Peters, Timothy J., Angioletti-Uberti, Stefano, Frenkel, Daan, Ravishankar, Shyamsundar, Gupta, Money, Wang, Jing J., Agapiou, David, Faulks, Megan L., Al-Eryani, Ghamdan, Luciani, Fabio, Gordon, Tom P., Reed, Joanne H., Danta, Mark, Carr, Andrew, Kelleher, Anthony D., Dore, Gregory J., Matthews, Gail, Brink, Robert, Bull, Rowena A., Suan, Dan, and Goodnow, Christopher C.

Published
2025
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132. A retrospective data analysis on the induction medications used in trauma rapid sequence intubations and their effects on outcomes

Author

Kuza, Catherine M, To, Jocelyn, Chang, Angela, Mert, Melissa, Yau, Anita, Singh, Mandeep, Choi, Katherine J, Huang, Samantha, Wier, Julian, Inaba, Kenji, Hirji, Sameer A, Spencer, Dean, Albertson, Spencer, Grigorian, Areg, and Nahmias, Jeffry T

Subjects
Clinical Research, Patient Safety, Cardiovascular, Good Health and Well Being, Adult, Data Analysis, Etomidate, Humans, Intubation, Intratracheal, Ketamine, Propofol, Rapid Sequence Induction and Intubation, Retrospective Studies, Trauma, Rapid sequence intubation, Induction agents, Clinical Sciences, Emergency & Critical Care Medicine, Orthopedics
Abstract

PurposeRapid sequence intubation (RSI) in trauma patients is common; however, the induction agents used have been debated. We determined which induction medications were used most frequently for adult trauma RSIs and their associations with hemodynamics and outcomes. We hypothesized that etomidate is the most commonly used induction agent and has similar outcomes to other induction agents.MethodsThis retrospective review at two U.S. level I trauma centers evaluated adult trauma patients undergoing RSI within 24 h of admission, between 01/01/2016 and 12/31/2017. We compared patient characteristics and outcomes by induction agent. Comparisons on the primary outcome of in-hospital mortality and secondary outcomes of peri-intubation hypotension, hospital and ICU length of stay (LOS), ventilator days, and complications used logistic regression or negative binomial regression. Regression models adjusted for hospital site, age, patient severity measures, and intubation location.ResultsAmong 1303 trauma patients undergoing RSI within 24 h of admission, 948 (73%) were intubated in the emergency department (ED) and 325 (25%) in the operating room (OR). The most common induction agents were etomidate (68%), propofol (17%), and ketamine (11%). In-hospital mortality was highest in the etomidate group (25.5%), followed by ketamine (17%), and propofol (1.8%).ConclusionEtomidate was most commonly used in ED intubations; propofol was most used in the OR. Compared to propofol, patients induced with etomidate had higher mortality and complication rates. Findings should be interpreted with caution given limited generalizability and residual confounding by indication.

Published
2022

133. Finite control of dielectric constant with magnetic field in Sm-doped Ba-Co U-type hexaferrites

Author

Malhi Parambir Singh, Kumar Sachin, Singh Mandeep, Singh Anupinder, and Sood Ashwani Kumar

Subjects
u-type hexaferrites, magnetic properties, impedance spectroscopy, magneto-dielectric coupling, Clay industries. Ceramics. Glass, TP785-869
Abstract

Emergence of memory devices based on magneto-electric coupling leads us to investigate the dielectric and magneto-dielectric properties of U-type hexaferrites. (Ba1-3xSm2x)4Co2Fe36O60 ceramics, where x = 0.0-0.25, with the interval of 0.05, have been produced via auto combustion method and sintering at 1200°C. Every sample has an RЇ3m symmetric hexagonal structure, according to the XRD study. The samples with lower Sm content, i.e. 0.0 < x < 0.15 have better magnetic properties than the samples having 0.15 < x < 0.25. Impedance spectroscopy has been used to study dielectric characteristics. The sample with x = 0.15 at 1.2 T and 1000Hz showed maximum magnetization and a magneto-electric coupling accompanied by a magnetic coefficient of about 104.9%, which is very high in case of hexaferrites. Therefore, these results will be fruitful from the application point of view.

Published
2023
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140. Tissue‐specific genotype–phenotype correlations among USH2A‐related disorders in the RUSH2A study

Author

Hufnagel, Robert B, Liang, Wendi, Duncan, Jacque L, Brewer, Carmen C, Audo, Isabelle, Ayala, Allison R, Branham, Kari, Cheetham, Janet K, Daiger, Stephen P, Durham, Todd A, Guan, Bin, Heon, Elise, Hoyng, Carel B, Iannaccone, Alessandro, Kay, Christine N, Michaelides, Michel, Pennesi, Mark E, Singh, Mandeep S, Ullah, Ehsan, and Group, for the Foundation Fighting Blindness Consortium Investigator

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Clinical Research, Eye Disease and Disorders of Vision, Neurosciences, Brain Disorders, Rare Diseases, Neurodegenerative, Genetics, 2.1 Biological and endogenous factors, 4.1 Discovery and preclinical testing of markers and technologies, Eye, Extracellular Matrix Proteins, Genetic Association Studies, Humans, Mutation, Retinitis Pigmentosa, Usher Syndromes, genotype, hearing loss, photoreceptor degeneration, retinitis pigmentosa, USH2A, Usher syndrome, Foundation Fighting Blindness Consortium Investigator Group, Clinical Sciences, Genetics & Heredity, Clinical sciences
Abstract

We assessed genotype-phenotype correlations among the visual, auditory, and olfactory phenotypes of 127 participants with Usher syndrome (USH2) (n =80) or nonsyndromic autosomal recessive retinitis pigmentosa (ARRP) (n = 47) due to USH2A variants, using clinical data and molecular diagnostics from the Rate of Progression in USH2A Related Retinal Degeneration (RUSH2A) study. USH2A truncating alleles were associated with USH2 and had a dose-dependent effect on hearing loss severity with no effect on visual loss severity within the USH2 subgroup. A group of missense alleles in an interfibronectin domain appeared to be hypomorphic in ARRP. These alleles were associated with later age of onset, larger visual field area, better sensitivity thresholds, and better electroretinographic responses. No effect of genotype on the severity of olfactory deficits was observed. This study unveils a unique, tissue-specific USH2A allelic hierarchy with important prognostic implications for patient counseling and treatment trial endpoints. These findings may inform clinical care or research approaches in others with allelic disorders or pleiotropic phenotypes.

Published
2022

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