1,065 results on '"Spring, David R."'
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102. Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents
103. An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds
104. C(sp3)–H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection
105. Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
106. GLP-1R is downregulated in beta cells of NOD mice and T1D patients
107. Direct Synthesis of N-Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling
108. Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules
109. Synthesis of Structurally Diverse N-Substituted Quaternary-Carbon-Containing Small Molecules from α,α-Disubstituted Propargyl Amino Esters
110. Stapled peptides as a new technology to investigate protein-protein interactions in human platelets
111. Second-generation CK2α inhibitors targeting the αD pocket
112. Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates
113. Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction† †Electronic supplementary information (ESI) available: Computational methods and structure files, chemical synthesis, fluorescence polarization assays, crystallographic data. See DOI: 10.1039/c7cc05379g
114. Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes† †Electronic supplementary information (ESI) available: Synthetic protocols, 1H/13C NMR and HR mass spectra are provided. CCDC 1443618–1443620 and 1534812–1534815. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc00964j Click here for additional data file. Click here for additional data file
115. Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst† †Dedicated to Professor Stuart L. Schreiber on the occasion of his 60th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05313k Click here for additional data file
116. Stereocontrolled semi-syntheses of deguelin and tephrosin† †Electronic supplementary information (ESI) available: 1H and 13C NMR spectra. See DOI: 10.1039/c6ob02659a Click here for additional data file
117. Assessment of structural diversity in combinatorial synthesis
118. Synthesis and utilization of functionalized polystyrene resins
119. Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling
120. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of actionElectronic supplementary information (ESI) available: All data supporting this study are included in the paper and provided as ESI accompanying this paper at the journal's website. See DOI: https://doi.org/10.1039/d2md00161f
121. Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction
122. Stereocontrolled semi-syntheses of deguelin and tephrosin
123. Partially Saturated Bicyclic Heteroaromatics as an sp3‐Enriched Fragment Collection
124. Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment‐Based Drug Discovery
125. Strategies for the Diversity-Oriented Synthesis of Macrocycles
126. Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection
127. Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides
128. Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1′-Biphenyl-2,2′,6,6′-tetrol
129. Cleavable linkers in antibody–drug conjugates
130. Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry
131. A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates
132. Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides
133. Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling
134. Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction
135. Synthesis and biological evaluation of 1,2-disubstituted 4-quinolone analogues of Pseudonocardia sp. natural products
136. Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections
137. Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck–Suzuki reaction† †Electronic supplementary information (ESI) available: Full experimental details, 1H and 13C NMR spectra and X-ray crystallographic data for compound 4d. CCDC 936207. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02547d Click here for additional data file. Click here for additional data file
138. Selective Aurora A-TPX2 Interaction Inhibitors Have In VivoEfficacy as Targeted Antimitotic Agents
139. C(sp3)–H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection.
140. Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery.
141. The reductive cleavage of picolinic amides
142. Synthesis of Structurally Diverse N-Substituted Quaternary-Carbon-Containing Small Molecules from α,α-Disubstituted Propargyl Amino Esters
143. Two-Component Stapling of Biologically Active and Conformationally Constrained Peptides: Past, Present, and Future
144. Bioinspired Total Synthesis of Bussealin E
145. Loving the poison: the methylcitrate cycle and bacterial pathogenesis
146. Semi-syntheses of the 11-hydroxyrotenoids sumatrol and villosinol
147. Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking
148. Stapled peptides as a new technology to investigate protein–protein interactions in human platelets
149. Second-generation CK2α inhibitors targeting the αD pocket
150. Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone
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