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Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferation and was accompanied by altered metabolism. Preventing HSC enlargement or reducing large HSCs in size averts the loss of stem cell potential under conditions causing stem cell exhaustion. Last, we show that murine and human HSCs enlarge during aging. Preventing this age-dependent enlargement improves HSC function. We conclude that small cell size is important for stem cell function in vivo and propose that stem cell enlargement contributes to their functional decline during aging.

Social epistemologists should be well-equipped to explain and evaluate the growing vulnerabilities associated with filter bubbles, echo chambers, and group polarization in social media. However, almost all social epistemology has been built for social contexts that involve merely a speaker-hearer dyad. Filter bubbles, echo chambers, and group polarization all presuppose much larger and more complex network structures. In this paper, we lay the groundwork for a properly social epistemology that gives the role and structure of networks their due. In particular, we formally define epistemic constructs that quantify the structural epistemic position of each node within an interconnected network. We argue for the epistemic value of a structure that we call the (m,k)-observer. We then present empirical evidence that (m,k)-observers are rare in social media discussions of controversial topics, which suggests that people suffer from serious problems of epistemic vulnerability. We conclude by arguing that social epistemologists and computer scientists should work together to develop minimal interventions that improve the structure of epistemic networks.

Recent work by Kahan et al. (2017) on the psychology of motivated numeracy in the context of intracultural disagreement suggests that people are less likely to employ their capabilities when the evidence runs contrary to their political ideology. This research has so far been carried out primarily in the USA regarding the liberal–conservative divide over gun control regulation. In this paper, we present the results of a modified replication that included an active reasoning intervention with Western European participants regarding both the hierarchy–egalitarianism and individualism–collectivism divides over immigration policy (n = 746; considerably less than the preregistration sample size). We reproduce the motivated numeracy effect, though we do not find evidence of increased polarization of high-numeracy participants., Web Information Systems

Scientists appeal to models when explaining phenomena. Such explanations are often dubbed model explanations or model-based explanations (short: ME). But what are the precise conditions for ME? Are ME special explanations? In our paper, we first rebut two definitions of ME and specify a more promising one. Based on this analysis, we single out a related conception that is concerned with explanations that are induced from working with a model. We call them ‘model-induced explanations’ (MIE). Second, we study three paradigmatic cases of alleged ME. We argue that all of them are MIE, upon closer examination. Third, we argue that this undermines the building consensus that model explanations are special explanations that, e.g., challenge the factivity of explanation. Instead, it suggests that what is special about models in science is the epistemology behind how models induce explanations.

Personalized content provided by recommender systems is an integral part of the current online news reading experience. However, news recommender systems are criticized for their'black-box' approach to data collection and processing, and for their lack of explainability and transparency. This paper focuses on explaining user profiles constructed from aggregated reading behavior data, used to provide content-based recommendations. The paper makes a first step toward consolidating epistemic values of news providers and news readers. We present an evaluation of an explanation interface reflecting these values, and find that providing users with different goals for self-actualization (i.e., Broaden Horizons vs. Discover the Unexplored) influences their reading intentions for news recommendations., Web Information Systems

Recently, many have argued that there are certain kinds of abstract mathematical explanations that are noncausal. In particular, the irrelevancy approach suggests that abstracting away irrelevant causal details can leave us with a noncausal explanation. In this paper, I argue that the common example of Renormalization Group (RG) explanations of universality used to motivate the irrelevancy approach deserves more critical attention. I argue that the reasons given by those who hold up RG as noncausal do not stand up to critical scrutiny. As a result, the irrelevancy approach and the line between casual and noncausal explanation deserves more scrutiny., Web Information Systems

Because idealizations frequently advance scientific understanding, many claim that falsehoods play an epistemic role. In this paper, we argue that these positions greatly overstate idealizations’ import for understanding. We introduce work on epistemic value to the debate surrounding idealizations and understanding, arguing that idealizations qua falsehoods confer only non-epistemic value to understanding. We argue for this claim by criticizing the leading accounts of how idealizations provide understanding. For each of these approaches, we show that: (a) idealizations’ false components promote only convenience instead of understanding and (b) only the true components of idealizations have epistemic value., Ethics & Philosophy of Technology

Simple idealized models seem to provide more understanding than opaque, complex, and hyper-realistic models. However, an increasing number of scientists are going in the opposite direction by utilizing opaque machine learning models to make predictions and draw inferences, suggesting that scientists are opting for models that have less potential for understanding. Are scientists trading understanding for some other epistemic or pragmatic good when they choose a machine learning model? Or are the assumptions behind why minimal models provide understanding misguided? In this paper, using the case of deep neural networks, I argue that it is not the complexity or black box nature of a model that limits how much understanding the model provides. Instead, it is a lack of scientific and empirical evidence supporting the link that connects a model to the target phenomenon that primarily prohibits understanding.