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101. Clinical Efficacy of Prophylactic Administration of a Second-Generation Antihistamine to Patients with Japanese Cedar Pollinosis

Author

Fujieda, Shigeharu, primary, Yamada, Takechiyo, additional, Kojima, Akihiro, additional, Kudo, Mutsuo, additional, Suzaki, Harumi, additional, Kadokura, Yoshiyuki, additional, Sanbe, Takeyuki, additional, Yoshihashi, Hidetaka, additional, Makiyama, Kiyoshi, additional, Ohki, Motofumi, additional, Ogoshi, Toshio, additional, Okubo, Kimihiro, additional, Yao, Kazuo, additional, Yosida, Takafumi, additional, Tsukuda, Mamoru, additional, Ohashi, Taku, additional, Kushita, Kayoko, additional, Hattori, Aya, additional, Ito, Yoshifumi, additional, Hamajima, Yuki, additional, Ohno, Nobuaki, additional, Suzuki, Motohiko, additional, Nakamura, Yoshihisa, additional, Tanaka, Yoshiko, additional, Murakami, Shingo, additional, Hama, Takemitsu, additional, Dejima, Kenji, additional, Hisa, Yasuo, additional, Hyo, Sawako, additional, Hirakawa, Katsuhiro, additional, Yajin, Koji, additional, Okano, Mitsuhiro, additional, Nishizaki, Kazunori, additional, Kataoka, Shingo, additional, Kawauchi, Hideyuki, additional, Matsuura, Koji, additional, Tono, Tetsuya, additional, Miyanohara, Ikuyo, additional, Kurono, Yuichi, additional, and Takenaka, Hiroshi, additional

Published
2007
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114. Clinical Usefulness of Five Odorant Jet Stream Olfactometry

Author

Miwa, Takaki, primary, Furukawa, Mitsuru, additional, Matsune, Shoji, additional, Kurono, Yuichi, additional, Harada, Hirobumi, additional, Kato, Toshihiko, additional, Tokumaru, Hisako, additional, Nakashima, Tadashi, additional, Ono, Nobuchika, additional, Yamashita, Hiroshi, additional, Tatsukawa, Takaharu, additional, Yajin, Koji, additional, Ogawa, Teruhiro, additional, Nishizaki, Kazunori, additional, Fukazawa, Keijiro, additional, Sakagami, Masafumi, additional, Matsumoto, Koji, additional, Yamane, Hideo, additional, Kubo, Nobuo, additional, Yamashita, Toshio, additional, Kanata, Hirokazu, additional, Hosoi, Hiroshi, additional, Suzuki, Motohiko, additional, Murakami, Shingo, additional, Otori, Nobuyoshi, additional, Moriyama, Hiroshi, additional, Yokomori, Enatsu, additional, Suzaki, Harumi, additional, Nakamura, Hideo, additional, Takahashi, Sugata, additional, Ikeda, Katsuhisa, additional, and Kobayashi, Toshimitsu, additional

Published
2004
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122. The Efficacy and Safety of Loratadine for Perennial Allergic Rhinitis in a Phase III, Randomized, Double-blind, Multi-Center Comparative Study

Author

Okuda, Minoru, primary, Ishikawa, Takeru, additional, Baba, Kohtaro, additional, Suzaki, Harumi, additional, Konno, Akiyoshi, additional, Okamoto, Yoshitaka, additional, Majima, Yuichi, additional, Ogino, Satoshi, additional, Kawauchi, Hideyuki, additional, Kurono, Yuichi, additional, and Nakashima, Mitsuyoshi, additional

Published
2002
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149. Effect of Histamine H1 Receptor Antagonists on TARC/CCL17 and MDC/CCL22 Production from CD14+ Cells Induced by Antigenic Stimulation in vitro.

Author

Shoji, Naruo, Asano, Kazuhito, Furuta, Atsuko, Hirano, Kojiro, and Suzaki, Harumi

Subjects
ANTIHISTAMINES, FEXOFENADINE, CHEMOKINES, PROTEIN kinases, EFFECT of drugs on cells, POLLEN -- Allergenicity, ENZYME-linked immunosorbent assay, ALLERGIES
Abstract

Background: Thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) are accepted to be important molecules in the development and maintenance of allergic diseases. Although several types of histamine H1 receptor antagonist (antihistamine) have been developed and used for the treatment of allergic diseases, the influence of antihistamines on TARC and MDC production is not well understood. Objective: The present study was undertaken to examine the influence of antihistamines on TARC and MDC production from CD14+ cells after antigenic stimulation in vitro. Methods: CD14+ cells prepared from patients with pollinosis to Japanese cedar pollen were stimulated with specific allergen extracted from Japanese cedar pollen (Cry j 1) in the presence of azelastine (AZE), ketotifen (KET), fexofenadine (FEX) and oxatomide (OXA) for 6 days. TARC and MDC levels in culture supernatants were examined by ELISA. We also examined the influence of FEX on TARC and MDC mRNA expression, phosphorylation of mitogen-activated protein kinases (MAPKs) and transcription factor activation in CD14+ cells after Cry j 1 stimulation. Results: FEX at 250 ng/ml, which is almost equal to therapeutic blood levels, caused a significant inhibition of TARC and MDC production.However, AZE, OXA and KET required higher concentrations than their therapeutic blood levels to suppress production of these factors. FEX at 250 ng/ml also suppressed NF-κB activation, phosphorylation of p38 MAPK and extracellular signal-regulated kinases 1 and 2 and expression of mRNA for TARC and MDC. Conclusions: These results suggest that antihistamines, especially FEX, suppress CC chemokine production from CD14+ cells through interference with antigen-mediated signaling and result in favorable modification of allergic disease states or conditions. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2011
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