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102. High-dose proton-based radiation therapy in the management of spine chordomas: outcomes and clinicopathological prognostic factors

Author

Rotondo, Ronny L., primary, Folkert, Wendy, additional, Liebsch, Norbert J., additional, Chen, Yen-Lin E., additional, Pedlow, Frank X., additional, Schwab, Joseph H., additional, Rosenberg, Andrew E., additional, Nielsen, G. Petur, additional, Szymonifka, Jackie, additional, Ferreira, Al E., additional, Hornicek, Francis J., additional, and Delaney, Thomas F., additional

Published
2015
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103. Abstract 17471: Cardiorenal Syndrome Patients With High NT-proBNP and Cystatin C Levels and Patients With Irreversible Cardiorenal Syndrome Identified by Persistently High Levels of Cystatin C Have Worse Outcomes in Cardiac Resynchronization Therapy: The BIOCRT Study

Author

Contractor, Jigar, primary, Szymonifka, Jackie, additional, Deano, Roderick C, additional, Chatterjee, Neal A, additional, Januzzi, James L, additional, Singh, Jagmeet P, additional, and Truong, Quynh A, additional

Published
2015
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105. Utility of dual-source computed tomography in cardiac resynchronization therapy-DIRECT study.

Author

Truong, Quynh A., Szymonifka, Jackie, Picard, Michael H., Thai, Wai-ee, Wai, Bryan, Cheung, Jim W., Heist, E. Kevin, Hoffmann, Udo, and Singh, Jagmeet P.

Abstract

Background: Dual-source computed tomography (CT) can evaluate left ventricular (LV) dyssynchrony, myocardial scar, and coronary venous anatomy in patients undergoing cardiac resynchronization therapy (CRT).Objective: We aimed to determine whether dual-source CT predicts clinical CRT outcomes and reduces intraprocedural time.Methods: In this prospective study, 54 patients scheduled for CRT (mean age 63 ± 11 years; 74% men) underwent preprocedural CT to assess their venous anatomy as well as CT-derived dyssynchrony metrics and myocardial scar. Based on 1:1 randomization, the implanting physician had preimplant knowledge of the venous anatomy in half the patients. In blinded analyses, we measured time to maximal wall thickness and inward wall motion to determine (1) CT global and segmental dyssynchrony and (2) concordance of lead location to regional LV mechanical contraction. End points were 6-month CRT response measured using heart failure clinical composite score and 2-year major adverse cardiac events (MACE).Results: There were 72% CRT responders and 17% with MACE. Two wall motion dyssynchrony indices-global wall motion and opposing anteroseptal-inferolateral wall motion-predicted MACE (P < .01). Lead location concordant to regions of maximal wall thickness was associated with less MACE (P < .01). No CT dyssynchrony metrics predicted 6-month CRT response (P = NS for all). Myocardial scar (43%), posterolateral wall scar (28%), and total scar burden did not predict outcomes (P = NS for all). Preknowledge of coronary venous anatomy by CT did not reduce implant or fluoroscopy time (P = NS for both).Conclusion: Two CT dyssynchrony metrics predicted 2-year MACE, and LV lead location concordant to regions of maximal wall thickness was associated with less MACE. Other CT factors had little utility in CRT. [ABSTRACT FROM AUTHOR]

Published
2018
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106. Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data.

Author

Orange, Dana E., Agius, Phaedra, DiCarlo, Edward F., Robine, Nicolas, Geiger, Heather, Szymonifka, Jackie, McNamara, Michael, Cummings, Ryan, Andersen, Kathleen M., Mirza, Serene, Figgie, Mark, Ivashkiv, Lionel B., Pernis, Alessandra B., Jiang, Caroline S., Frank, Mayu O., Darnell, Robert B., Lingampali, Nithya, Robinson, William H., Gravallese, Ellen, and the Accelerating Medicines Partnership in Rheumatoid Arthritis and Lupus Network

Subjects
OSTEOARTHRITIS, GENETICS of rheumatoid arthritis, ALGORITHMS, AUTOANTIBODIES, BIOMARKERS, BLOOD sedimentation, C-reactive protein, CLUSTER analysis (Statistics), GENE expression, GLYCOPROTEINS, GROWTH factors, INFLAMMATION, LEUCOCYTES, PAIN, RNA, SYNOVIAL membranes, SEVERITY of illness index, SEQUENCE analysis, GENETICS
Abstract

Objective: In this study, we sought to refine histologic scoring of rheumatoid arthritis (RA) synovial tissue by training with gene expression data and machine learning. Methods: Twenty histologic features were assessed in 129 synovial tissue samples (n = 123 RA patients and n = 6 osteoarthritis [OA] patients). Consensus clustering was performed on gene expression data from a subset of 45 synovial samples. Support vector machine learning was used to predict gene expression subtypes, using histologic data as the input. Corresponding clinical data were compared across subtypes. Results: Consensus clustering of gene expression data revealed 3 distinct synovial subtypes, including a high inflammatory subtype characterized by extensive infiltration of leukocytes, a low inflammatory subtype characterized by enrichment in pathways including transforming growth factor β, glycoproteins, and neuronal genes, and a mixed subtype. Machine learning applied to histologic features, with gene expression subtypes serving as labels, generated an algorithm for the scoring of histologic features. Patients with the high inflammatory synovial subtype exhibited higher levels of markers of systemic inflammation and autoantibodies. C‐reactive protein (CRP) levels were significantly correlated with the severity of pain in the high inflammatory subgroup but not in the others. Conclusion: Gene expression analysis of RA and OA synovial tissue revealed 3 distinct synovial subtypes. These labels were used to generate a histologic scoring algorithm in which the histologic scores were found to be associated with parameters of systemic inflammation, including the erythrocyte sedimentation rate, CRP level, and autoantibody levels. Comparison of gene expression patterns to clinical features revealed a potentially clinically important distinction: mechanisms of pain may differ in patients with different synovial subtypes. [ABSTRACT FROM AUTHOR]

Published
2018
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107. Postoperative Myocardial Injury and Inflammation Is Not Blunted by a Trial of Atorvastatin in Orthopedic Surgery Patients.

Author

Bass, Anne, Szymonifka, Jackie, Rondina, Matthew, Bogardus, Margaret, Scott, Mitchell, Woller, Scott, Stevens, Scott, Eby, Charles, Merritt, Kerri, Valle, Alejandro, Moskowitz, Gerard, Flores, Eva, and Gage, Brian

Abstract

Background: Orthopedic patients are at risk for adverse postoperative cardiovascular outcomes. Questions/Purposes: This pilot randomized controlled trial (RCT) of atorvastatin vs. placebo in orthopedic surgery patients was performed in order to assess: (1) the prevalence of perioperative myocardial injury; (2) the effect of atorvastatin on perioperative inflammation; and (3) the feasibility of performing a large RCT of statin therapy in orthopedic patients. Methods: Hip fracture (hip Fx) and total hip and knee replacement (THR and TKR) patients were randomized 1:1 to atorvastatin 40 mg daily vs. placebo, starting preoperatively and continuing until postoperative day (POD) 45. High-sensitivity cardiac troponin I (hs-cTnI), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) were measured preoperatively and on POD 2. Patients were monitored for adverse events until POD 90. Results: Five hundred fifty-six patients were screened, 22 were recruited (4 hip Fx, 11 THR, 7 TKR), and 2 withdrew. Most (80%) had detectable hs-cTnI (> 1.1 pg/mL) preoperatively. Twenty percent had a perioperative rise in hs-cTnI (≥ 10 pg/mL), which was not blunted by atorvastatin. Hs-CRP rose in 19/20 patients, and IL-6 rose in all patients. However, atorvastatin did not blunt the rise in these inflammatory biomarkers. On POD 2, IL-6 and hs-cTnI levels correlated ( ρ = 0.59, p = 0.02). Recruitment was limited by the high prevalence of statin use in the screened population and a high prevalence of exclusions among hip fracture patients. Conclusion: Perioperative myocardial injury and inflammation are common in orthopedic patients and do not appear to be reduced in those randomized to atorvastatin. Trial Registration: NCT02197065 [ABSTRACT FROM AUTHOR]

Published
2018
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110. Clinical characteristics and treatment outcomes of patients with metastatic, MET-amplified esophagogastric cancers.

Author

Kwak, Eunice Lee, primary, Lennerz, Jochen K, additional, Szymonifka, Jackie, additional, Corcoran, Ryan Bruce, additional, Clark, Jeffrey W., additional, Russo, Andrea Lyn, additional, Borger, Darrell R., additional, Blaszkowsky, Lawrence Scott, additional, Dias, Lauren Elizabeth, additional, Faris, Jason Edward, additional, Murphy, Janet E., additional, Fidias, Panos, additional, Lennes, Inga Tolin, additional, Azzoli, Christopher G., additional, Gainor, Justin F., additional, Mullen, John Thomas, additional, Lauwers, Gregory Y, additional, Ryan, David P., additional, Iafrate, A. John, additional, and Hong, Theodore S., additional

Published
2015
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113. DIAGNOSIS OF NECROTIC INTRAPLAQUE CORES BY DUAL ENERGY CORONARY COMPUTED TOMOGRAPHIC ANGIOGRAPHY IN VICTIMS OF SUDDEN CORONARY DEATH: VALIDATION TO A PATHOLOGIC GOLD STANDARD

Author

Elmore, Kimberly, primary, Cho, Iksung, additional, Hartaigh, Briain O, additional, Schulman-Marcus, Joshua, additional, Szymonifka, Jackie, additional, Earls, James, additional, Yahagi, Kazuyuki, additional, Xiong, Guanglei, additional, Starikov, Anna, additional, Joner, Michael, additional, Virmani, Renu, additional, and Min, James, additional

Published
2015
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115. Preliminary Results of a Phase II Trial of Proton Radiotherapy for Pediatric Rhabdomyosarcoma

Author

Ladra, Matthew M., primary, Szymonifka, Jackie D., additional, Mahajan, Anita, additional, Friedmann, Alison M., additional, Yong Yeap, Beow, additional, Goebel, Claire P., additional, MacDonald, Shannon M., additional, Grosshans, David R., additional, Rodriguez-Galindo, Carlos, additional, Marcus, Karen J., additional, Tarbell, Nancy J., additional, and Yock, Torunn I., additional

Published
2014
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116. Diagnostic performance of cardiac imaging methods to diagnose ischaemia-causing coronary artery disease when directly compared with fractional flow reserve as a reference standard: a meta-analysis.

Author

Danad, Ibrahim, Szymonifka, Jackie, Twisk, Jos W. R., Norgaard, Bjarne L., Zarins, Christopher K., Knaapen, Paul, and Min, James K.

Abstract

Aims The aim of this study was to determine the diagnostic performance of single-photon emission computed tomography (SPECT), stress echocardiography (SE), invasive coronary angiography (ICA), coronary computed tomography angiography (CCTA), fractional flow reserve (FFR) derived from CCTA (FFRCT), and cardiac magnetic resonance (MRI) imaging when directly compared with an FFR reference standard. Method and results PubMed andWeb of Knowledge were searched for investigations published between 1 January 2002 and 28 February 2015. Studies performing FFR in at least 75% of coronary vessels for the diagnosis of ischaemic coronary artery disease (CAD) were included. Twenty-three articles reporting on 3788 patients and 5323 vessels were identified.Meta-analysis was performed for pooled sensitivity, specificity, likelihood ratios (LR), diagnostic odds ratio, and summary receiver operating characteristic curves. In contrast to ICA, CCTA, and FFRCT reports, studies evaluating SPECT, SE, and MRI were largely retrospective, single-centre and with generally smaller study samples. On a per-patient basis, the sensitivity of CCTA (90%, 95% CI: 86-93), FFRCT (90%, 95% CI: 85-93), and MRI (90%, 95% CI: 75-97) were higher than for SPECT (70%, 95% CI: 59-80), SE (77%, 95% CI: 61-88), and ICA (69%, 95% CI: 65-75). The highest and lowest per-patient specificity was observed for MRI (94%, 95% CI: 79-99) and for CCTA (39%, 95% CI: 34-44), respectively. Similar specificities were noted for SPECT (78%, 95% CI: 68-87), SE (75%, 95% CI: 63-85), FFRCT (71%, 95% CI: 65-75%), and ICA (67%, 95% CI: 63-71). On a per-vessel basis, the highest sensitivity was for CCTA (pooled sensitivity, 91%: 88-93), MRI (91%: 84-95), and FFRCT (83%, 78-87), with lower sensitivities for ICA (71%, 69-74), and SPECT (57%: 49-64). Per-vessel specificity was highest for MRI (85%, 79-89), FFRCT (78%: 78-81), and SPECT (75%: 69-80), whereas ICA (66%: 64-68) and CCTA (58%: 55-61) yielded a lower specificity. Conclusions In this meta-analysis comparing cardiac imaging methods directly to FFR, MRI had the highest performance for diagnosis of ischaemia-causing CAD, with lower performance for SPECT and SE. Anatomic methods of CCTA and ICA yielded lower specificity, with functional assessment of coronary atherosclerosis by SE, SPECT, and FFRCT improving accuracy. [ABSTRACT FROM AUTHOR]

Published
2017
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119. Validation of the NSABP neoadjuvant rectal score (NAR) in a prospective phase II study evaluating an experimental regimen and a standard chemoradiation cohort with molecular genotyping.

Author

Hong, Theodore S., primary, Szymonifka, Jackie, additional, Yothers, Greg, additional, Blaszkowsky, Lawrence Scott, additional, Russo, Andrea Lyn, additional, Wo, Jennifer Yon-Li, additional, Mamon, Harvey J., additional, Kwak, Eunice Lee, additional, Zhu, Andrew X., additional, Allen, Jill N., additional, Clark, Jeffrey W., additional, and Ryan, David P., additional

Published
2014
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121. SUPERIORITY OF CORONARY SINUS CARDIAC BIOMARKER SAMPLING OVER PERIPHERAL VENOUS BLOOD FOR PROGNOSTICATION IN CARDIAC RESYNCHRONIZATION THERAPY: THE BIOCRT STUDY

Author

Truong, Quynh A., primary, Januzzi, James, additional, Szymonifka, Jackie, additional, Thai, Wai-ee, additional, Wai, Bryan, additional, Sharma, Umesh, additional, Sandoval, Ryan, additional, Grunau, Zachary, additional, Basnet, Sandeep, additional, Babatunde, Adefolakemi, additional, Ajijola, Olujimi, additional, and Singh, Jagmeet, additional

Published
2014
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122. O010 The relationship between intrathoracic fat depots, circulating inflammatory biomarkers and coronary artery disease suggests a local atherogenic effect of the pericoronary adipose tissue compartment

Author

Maurovich-Horvat, Pal, primary, Kallianos, Kimberly, additional, Engel, Leif-Christopher, additional, Szymonifka, Jackie, additional, Schlett, Christopher L., additional, Koenig, Wolfgang, additional, Hoffmann, Udo, additional, and Truong, Quynh A., additional

Published
2014
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128. Mutational and Clinical Predictors of Pathologic Complete Response in the Treatment of Locally Advanced Rectal Cancer

Author

Russo, Andrea L., primary, Ryan, David P., additional, Borger, Darrell R., additional, Wo, Jennifer Y., additional, Szymonifka, Jackie, additional, Liang, Wen-Yih, additional, Kwak, Eunice L., additional, Blaszkowsky, Lawrence S., additional, Clark, Jeffrey W., additional, Allen, Jill N., additional, Zhu, Andrew X., additional, Berger, David L., additional, Cusack, James C., additional, Mamon, Harvey J., additional, Haigis, Kevin M., additional, and Hong, Theodore S., additional

Published
2013
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129. β-Catenin Mutation Status and Outcomes in Sporadic Desmoid Tumors

Author

Mullen, John T., primary, DeLaney, Thomas F., additional, Rosenberg, Andrew E., additional, Le, Long, additional, Iafrate, A. John, additional, Kobayashi, Wendy, additional, Szymonifka, Jackie, additional, Yeap, Beow Y., additional, Chen, Yen-Lin, additional, Harmon, David C., additional, Choy, Edwin, additional, Yoon, Sam S., additional, Raskin, Kevin A., additional, Hornicek, Francis J., additional, and Nielsen, Gunnlauger P., additional

Published
2013
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131. DNA mutation frequencies in metastatic small bowel adenocarcinoma (mSBA) in comparison to gastric (mGC), colon (mCC), and rectal cancer (mRC): Continuum or cutpoint?

Author

Murphy, Janet E., primary, Russo, Andrea Lyn, additional, Szymonifka, Jackie, additional, Kwak, Eunice Lee, additional, Allen, Jill N., additional, Zhu, Andrew X., additional, Blaszkowsky, Lawrence Scott, additional, Clark, Jeffrey W., additional, Ryan, David P., additional, Hong, Theodore S., additional, and Borger, Darrell R., additional

Published
2013
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132. FOLFIRINOX in Locally Advanced Pancreatic Cancer: The Massachusetts General Hospital Cancer Center Experience

Author

Faris, Jason E., primary, Blaszkowsky, Lawrence S., additional, McDermott, Shaunagh, additional, Guimaraes, Alexander R., additional, Szymonifka, Jackie, additional, Huynh, Mai Anh, additional, Ferrone, Cristina R., additional, Wargo, Jennifer A., additional, Allen, Jill N., additional, Dias, Lauren E., additional, Kwak, Eunice L., additional, Lillemoe, Keith D., additional, Thayer, Sarah P., additional, Murphy, Janet E., additional, Zhu, Andrew X., additional, Sahani, Dushyant V., additional, Wo, Jennifer Y., additional, Clark, Jeffrey W., additional, Fernandez-del Castillo, Carlos, additional, Ryan, David P., additional, and Hong, Theodore S., additional

Published
2013
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133. Neoadjuvant chemoradiotherapy for patients with high-risk extremity and truncal sarcomas: A 10-year single institution retrospective study

Author

Hong, Nicole J. Look, primary, Hornicek, Francis J., additional, Harmon, David C., additional, Choy, Edwin, additional, Chen, Yen-Lin, additional, Yoon, Sam S., additional, Nielsen, G. Petur, additional, Szymonifka, Jackie, additional, Yeap, Beow Y., additional, DeLaney, Thomas F., additional, and Mullen, John T., additional

Published
2013
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134. CORONARY SINUS LEVEL OF GALECTIN-3 IS A BETTER PREDICTOR THAN PERIPHERAL VENOUS LEVEL OF MAJOR ADVERSE CARDIAC EVENTS IN PATIENTS WITH CARDIAC RESYNCHRONIZATION THERAPY

Author

Truong, Quynh A., primary, Thai, Wai-ee, additional, Szymonifka, Jackie, additional, Basnet, Sandeep, additional, Wai, Bryan, additional, Grunau, Zachary, additional, Beaudoin, Jonathan, additional, Smith, Chelsea L., additional, Babatunde, Adefolakemi, additional, Ajijola, Olujimi, additional, Singh, Jagmeet, additional, and Januzzi, James, additional

Published
2013
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135. SERIAL MEASUREMENT OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7 PREDICTS CHRONIC HEART FAILURE OUTCOMES AND VENTRICULAR REMODELING: RESULTS FROM THE PROBNP OUTPATIENT TAILORED CHRONIC HEART FAILURE THERAPY (PROTECT) STUDY

Author

Motiwala, Shweta, primary, Bhardwaj, Anju, additional, Szymonifka, Jackie, additional, Belcher, Arianna, additional, Weiner, Rory, additional, Baggish, Aaron, additional, Gaggin, Hanna, additional, and Januzzi, James, additional

Published
2013
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137. SERIAL MEASUREMENT OF GALECTIN-3 PREDICTS CHRONIC HEART FAILURE OUTCOMES AND VENTRICULAR REMODELING: RESULTS FROM THE PROBNP OUTPATIENT TAILORED CHRONIC HEART FAILURE THERAPY (PROTECT) STUDY

Author

Motiwala, Shweta, primary, Szymonifka, Jackie, additional, Belcher, Arianna, additional, Weiner, Rory, additional, Baggish, Aaron, additional, Sluss, Patrick, additional, Gaggin, Hanna, additional, Bhardwaj, Anju, additional, and Januzzi, James, additional

Published
2013
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138. Mutational analysis of locally advanced rectal cancer and response to neoadjuvant chemoradiation.

Author

Russo, Andrea Lyn, primary, Ryan, David P., additional, Borger, Darrell R., additional, Wo, Jennifer Yon-Li, additional, Szymonifka, Jackie, additional, Kwak, Eunice Lee, additional, Blaszkowsky, Lawrence Scott, additional, Clark, Jeffrey W., additional, Allen, Jill N., additional, Zhu, Andrew X., additional, Berger, David L., additional, Cusack, James C., additional, Haigis, Kevin M., additional, and Hong, Theodore S., additional

Published
2013
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139. Seven-year median time to progression with thalidomide for smoldering myeloma: partial response identifies subset requiring earlier salvage therapy for symptomatic disease

Author

Barlogie, Bart, van Rhee, Frits, Shaughnessy, John D., Jr, Epstein, Joshua, Yaccoby, Shmuel, Pineda-Roman, Mauricio, Hollmig, Klaus, Alsayed, Yazan, Hoering, Antje, Szymonifka, Jackie, Anaissie, Elias, Petty, Nathan, Kumar, Naveen S., Srivastava, Geetika, Jenkins, Bonnie, Crowley, John, and Zeldis, Jerome B.

Published
2008
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143. Prognostic Factors and Outcomes of Patients with Myxofibrosarcoma

Author

Look Hong, Nicole J., primary, Hornicek, Francis J., additional, Raskin, Kevin A., additional, Yoon, Sam S., additional, Szymonifka, Jackie, additional, Yeap, Beow, additional, Chen, Yen-Lin, additional, DeLaney, Thomas F., additional, Nielsen, G. Petur, additional, and Mullen, John T., additional

Published
2012
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144. Thalidomide in Total Therapy 2 Overcomes Inferior Prognosis of Myeloma with Low Expression of the Glucocorticoid Receptor Gene NR3C1

Author

Heuck, Christoph J., primary, Szymonifka, Jackie, additional, Hansen, Emily, additional, Shaughnessy, John D., additional, Usmani, Saad Z., additional, van Rhee, Frits, additional, Anaissie, Elias, additional, Nair, Bijay, additional, Waheed, Sarah, additional, Alsayed, Yazan, additional, Petty, Nathan, additional, Bailey, Clyde, additional, Epstein, Joshua, additional, Hoering, Antje, additional, Crowley, John, additional, and Barlogie, Bart, additional

Published
2012
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146. Multicenter randomized phase II trial of cisplatin, irinotecan plus bevacizumab (PCA) versus docetaxel, cisplatin, irinotecan plus bevacizumab (TPCA) in patients (pts) with metastatic esophagogastric cancer (MEGCA).

Author

Enzinger, Peter C., primary, Kwak, Eunice Lee, additional, Szymonifka, Jackie, additional, Abrams, Thomas Adam, additional, Regan, Eileen, additional, Malinowski, Paige, additional, Shih, Kent C., additional, Allen, Jill N., additional, Jackson, Nadine, additional, Chan, Jennifer A., additional, Fidias, Panos, additional, Ryan, David P., additional, Fuchs, Charles S., additional, and Bendell, Johanna C., additional

Published
2012
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147. Neoadjuvant chemoradiotherapy for patients with high-risk extremity and truncal sarcomas: A 10-year follow-up study.

Author

Look Hong, Nicole Jannelle, primary, Hornicek, Francis J, additional, Harmon, David C., additional, Choy, Edwin, additional, Chen, Yen-Lin, additional, Yoon, Sam S., additional, Nielsen, G. Petur, additional, Szymonifka, Jackie, additional, Yeap, Beow Yong, additional, DeLaney, Thomas F., additional, and Mullen, John Thomas, additional

Published
2012
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148. Metronomic therapy for heavily pretreated relapsed/refractory multiple myeloma (RRMM).

Author

Papanikolaou, Xenofon, primary, Szymonifka, Jackie, additional, Mitchell, Alan, additional, Keller, Jason, additional, Heuck, Christoph Johann, additional, Waheed, Sarah, additional, Usmani, Saad Zafar, additional, Nair, Bijay, additional, Van Rhee, Frits, additional, Medlin, Stephen Charles, additional, Bailey, Clyde, additional, Petty, Nathan, additional, Hoering, Antje, additional, Crowley, John, additional, and Barlogie, Bart, additional

Published
2012
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149. Panitumumab in Patients with KRAS Wild-Type Colorectal Cancer after Progression on Cetuximab

Author

Wadlow, Raymond C., primary, Hezel, Aram F., additional, Abrams, Thomas A., additional, Blaszkowsky, Lawrence S., additional, Fuchs, Charles S., additional, Kulke, Matthew H., additional, Kwak, Eunice L., additional, Meyerhardt, Jeffrey A., additional, Ryan, David P., additional, Szymonifka, Jackie, additional, Wolpin, Brian M., additional, Zhu, Andrew X., additional, and Clark, Jeffrey W., additional

Published
2012
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150. Novel Heart Failure Biomarkers Predict Improvement of Mitral Regurgitation in Patients Receiving Cardiac Resynchronization Therapy—The BIOCRT Study

Author

Beaudoin, Jonathan, Singh, Jagmeet P., Szymonifka, Jackie, Zhou, Qing, Levine, Robert A., Januzzi, James L., and Truong, Quynh A.

Abstract

Cardiac resynchronization therapy (CRT) improves mitral regurgitation (MR) in a subset of patients. We hypothesized that biomarkers (amino-terminal pro-B type natriuretic peptide, high-sensitivity troponin I, galectin-3 [gal-3], and soluble ST2) might predict MR response after CRT.

Published
2016
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