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811 results on '"Takamatsu, S."'

101. A Multi-Slice Dual Layer MR-Compatible Animal PET System

Author

Yamamoto, S., primary, Hatazawa, J., additional, Imaizumi, M., additional, Shimosegawa, E., additional, Aoki, M., additional, Sugiyama, E., additional, Kawakami, M., additional, Takamatsu, S., additional, Minato, K., additional, Matsumoto, K., additional, and Senda, M., additional

Published
2009
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123. A multi-slice dual layer MR-compatible animal PET system: K-PET I.

Author

Kim, Sun I., Suh, Tae Suk, Magjarevic, R., Nagel, J. H., Yamamoto, Seiichi, Mashino, H., Takamatsu, S., Matsumoto, K., and Senda, M.

Abstract

We are now developing a multi-slice depth-of interaction (DOI) MR-compatible PET system (K-PET I). The PET is for imaging small animals such as mouse or rat. It employs DOI block detectors made of MLSs, optical fibers, and multi-channel position sensitive photo-multiplier tubes (PSPMTs). The size of a single MLS was 2.5mm × 3.5mm × 3.5mm and eight MLSs were combined to form a DOI block detector proposed by Murayama [1] and connected to four optical fibers via light guides. Thirty two sets of block detectors were arranged in a circular ring of which diameter is 51mm. Position histograms showed good separations for all block detectors. Timing resolution of 6ns FWHM was obtained with the compact PCI based coincidence system. The PET has 3 imaging slice, two layers DOI detection capability, and spatial resolutions of around 2mm FWHM in transaxial and axial directions. The K-PET I will be combined with an animal MRI system for molecular imaging research using small animals. [ABSTRACT FROM AUTHOR]

Published
2007
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136. Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase.

Author

Stafforini, D M, primary, Satoh, K, additional, Atkinson, D L, additional, Tjoelker, L W, additional, Eberhardt, C, additional, Yoshida, H, additional, Imaizumi, T, additional, Takamatsu, S, additional, Zimmerman, G A, additional, McIntyre, T M, additional, Gray, P W, additional, and Prescott, S M, additional

Published
1996
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145. Effects of the herbal medicine composition 'Saiko-ka-ryukotsu-borei-To' on the function of endothelial progenitor cells in hypertensive rats.

Author

Iijima H, Daikonya A, Takamatsu S, Kanno A, Magariyama K, Yoshikawa K, Takamiya T, Ueda Y, Yakubo S, Matsumoto T, Ueno T, Yamori Y, Fukuda N, and Kitanaka S

Abstract

Endothelial progenitor cells (EPCs) are known to repair vascular injuries. Recent studies suggest that Saiko-ka-ryukotsu-borei-To (SKRBT), a traditional herbal medicine that has been used to treat stress-related neuropsychiatric disorders, has protective effects on cardiovascular diseases such as hypertension and arteriosclerosis. Spontaneously hypertensive rats (SHRs) were fed diets containing lyophilized SKRBT extract for 6 weeks. Peripheral blood mononuclear cells (MNCs) were isolated and cultured to assay EPC colony formation. Oxidative stress in MNCs was evaluated by thiobarbituric acid reactive substance (TBARS) assay and flowcytometric analyses. Treatment with SKRBT increased EPC colony numbers significantly (p<0.05) with decrease in oxidative stress and without affecting blood pressure in SHRs. Treatment with SKRBT did not reduce the expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits in cardiovascular organs. Serum IL-6 level was significantly reduced. SKRBT is a feasible herbal medicine that protects against cardiovascular diseases through an increase in EPC function along with anti-oxidative effects, and may affect the link between chronic inflammation and cardiovascular disease. [ABSTRACT FROM AUTHOR]

Published
2013
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