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1,169 results on '"Tanaka, Akio"'

104. Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan

Author

Mizuno, Masashi, Ito, Yasuhiko, Tanaka, Akio, Suzuki, Yasuhiro, Hiramatsu, Hideki, Watanabe, Midoriko, Tsuruta, Yoshikazu, Matsuoka, Teppei, Ito, Isao, Tamai, Hiroshi, Kasuga, Hirotake, Shimizu, Hideaki, Kurata, Hisashi, Inaguma, Daijo, Hiramatsu, Takeyuki, Horie, Masanobu, Naruse, Tomohiko, Maruyama, Shoichi, Imai, Enyu, Yuzawa, Yukio, and Matsuo, Seiichi

Published
2011
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114. Magnetic field analysis of an arbitrary shaped coil using shape functions

Author

Ishida, Koichi, Itaya, Toshiya, Tanaka, Akio, and Takehira, Nobuo

Subjects
Fourier transformations -- Analysis, Magnetic fields -- Analysis, Business, Electronics, Electronics and electrical industries
Abstract

In eddy-current sensors and eddy-current testing, it is important to analyze the magnetic field of the coil. Toward this end, we analyzed magnetic fields in various coils, such as circular and rectangular coils. We used the double Fourier transformation and applied it to the eddy-current problem of coils facing a sheet conductor. However, only a limited number of coil shapes could be analyzed by this method. We therefore devised a method of magnetic field analysis that could be applied to a variety of coils by double Fourier transformation. We focused attention on the generated magnetic field of the coil, which is a basic characteristic. Our analysis method is made applicable to a much larger variety of coil shapes by defining a completely new type of function, called shape functions. We verified the validity of the analytical results experimentally. Although the Biot-Savart law may be used to analyze magnetic fields of coils, the law is not applicable when the coil faces a sheet conductor. Index Terms--Arbitrary, coil, magnetic field, shape function.

Published
2009

115. Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model

Author

Nishimura, Hayato, Ito, Yasuhiko, Mizuno, Masashi, Tanaka, Akio, Morita, Yoshiki, Maruyama, Shoichi, Yuzawa, Yukio, and Matsuo, Seiichi

Subjects
Mineralocorticoids -- Properties, Neovascularization -- Evaluation, Peritonitis -- Physiological aspects, Rats -- Physiological aspects, Rats -- Diseases, Rattus -- Physiological aspects, Rattus -- Diseases, Steroid hormones -- Receptors, Steroid hormones -- Properties, Biological sciences
Abstract

Peritoneal fibrosis (PF) is an important complication of long-term peritoneal dialysis. Although mineralocorticoid and mineralocorticoid receptor (MR) have attracted increasing attention in the field of vascular injury, including the heart, kidney, and vessels, little is known about the role of mineralocorticoid in PF. This work was designed to explore the effects of MR blockade on PF. We developed a new model of PF in rats based on mechanical scraping of the peritoneum. This model is characterized by acute-phase inflammation (neutrophil and macrophage infiltration on days 0-3) and late-phase PF ([alpha]-smooth muscle actin-positive fibroblast infiltration, type III collagen accumulation, and neoangiogenesis on days 7-14). Peritoneal thickening peaked on day 14. MR was expressed in rat peritoneum and a rat fibroblast cell line. Expression of its effector kinase [serum- and glucocorticoid-induced kinase-1 (Sgk1)], transforming growth factor-[beta] (TGF-[beta]), plasminogen activator inhibitor-1 (PAI-1), and CD31-positive vessels increased during the course of PF. Rats were treated with spironolactone, angiotensin receptor blockade (ARB), or angiotensin-converting enzyme inhibitor (ACEI)-ARB-spironolactone starting at 6 h after peritoneal scraping. All parameters, including peritoneal thickening, number of macrophages and CD31-positive vessels, and expression of monocyte chemoattractant protein-l, TGF[beta] PAI-1, and Sgk1, were significantly suppressed by spironolactone (10 mg*[kg.sup.-1]*[day.sup.-1]). The effects of spironolactone (10 and 20 mg*[kg.sup.-1]*[day.sup.-1]) were very similar to those of triple blockade. ARB, but not ACEI, significantly reduced peritoneal thickening. Furthermore, peritoneal function assessed by peritoneal equilibration test was significantly improved by spironolactone. Our results suggest that MR is a potential target to prevent inflammation-induced PF in patients on peritoneal dialysis. serum- and glucocorticoid-induced kinase-1; renin-angiotensin-aldosterone system; ultrafiltration failure; neoangiogenesis

Published
2008

133. Histamine‐ or vascular endothelial growth factor‐induced tissue factor expression and gap formation between vascular endothelial cells are synergistically enhanced by lipopolysaccharide, tumor necrosis factor‐α, interleukin (IL)‐33 or IL‐1β

Author

Kamegashira, Akiko, primary, Yanase, Yuhki, additional, Takahagi, Shunsuke, additional, Saito, Ryo, additional, Uchida, Kazue, additional, Kawaguchi, Tomoko, additional, Ishii, Kaori, additional, Tanaka, Akio, additional, Ozawa, Koichiro, additional, and Hide, Michihiro, additional

Published
2020
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