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101. Additional file 1 of Biological aging mediates the associations between urinary metals and osteoarthritis among U.S. adults

Author

Chen, Li, Zhao, Ying, Liu, Fangqu, Chen, Huimin, Tan, Tianqi, Yao, Ping, and Tang, Yuhan

Abstract

Additional file 1: Fig. S1. Directed acyclic graph. Fig. S2. Pearson’s correlation matrix. Fig. S3. Weighted values of urinary metals for OA in WQS models. Fig. S4. Associations of the urinary metals with OA risk estimated by Bayesian Kernel Machine Regression (BKMR). Table S1. Distributions of metals in the study population. Table S2. OR (95% CI) in OA associated with single and mixed urinary metals levels with further adjustment for occupation. Table S3. OR (95% CI) in OA associated with single and mixed urinary metals levels with further adjustment for other diseases and medicine use. Table S4. OR (95% CI) in OA associated with single and mixed urinary metals levels with further adjustment for survey cycle. Table S5. OR (95% CI) in OA associated with single and mixed urinary metals levels after excluding participants with abnormal urinary creatinine. Table S6. OR (95% CI) in OA associated with single and mixed urinary metals levels after excluding pregnant participants. Table S7. Biological aging markers as mediators in the associations of single metals with OA risk. Table S8. Telomere length and biological age/biological age as serial mediators in the associations of single metals with OA risk.

Published
2022
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103. Tree peony PsMYB44 negatively regulates petal blotch distribution by inhibiting dihydroflavonol-4-reductase gene expression.

Author

Luan, Yuting, Chen, Zijie, Tang, Yuhan, Sun, Jing, Meng, Jiasong, Tao, Jun, and Zhao, Daqiu

Subjects
TREE peony, GENE expression, AMINO acid sequence, NICOTIANA, GENE silencing, REPORTER genes, GENE regulatory networks
Abstract

Background and Aims The tree peony (Paeonia suffruticosa Andr.) has been widely cultivated as a field plant, and petal blotch is one of its important traits, which not only promotes proliferation but also confers high ornamental value. However, the regulatory network controlling blotch formation remains elusive owing to the functional differences and limited conservation of transcriptional regulators in dicots. Methods We performed phylogenetic analysis to identify MYB44-like transcription factors in P. suffruticosa blotched cultivar 'High noon' petals. A candidate MYB44-like transcription factor, PsMYB44, was analysed via expression pattern analysis, subcellular localization, target gene identification, gene silencing in P. suffruticosa petals and heterologous overexpression in tobacco. Key Results A blotch formation-related MYB44-like transcription factor, PsMYB44, was cloned. The C-terminal of the PsMYB44 amino acid sequence had a complete C2 motif that affects anthocyanin biosynthesis, and PsMYB44 was clustered in the MYB44-like transcriptional repressor branch. PsMYB44 was located in the nucleus, and its spatial and temporal expression patterns were negatively correlated with blotch formation. Furthermore, a yeast one-hybrid assay showed that PsMYB44 could target the promoter of the late anthocyanin biosynthesis-related dihydroflavonol-4-reductase (DFR) gene, and a dual-luciferase assay demonstrated that PsMYB44 could repress PsDFR promoter activity. On the one hand, overexpression of PsMYB44 significantly faded the red colour of tobacco flowers and decreased the anthocyanin content by 42.3 % by downregulating the expression level of the tobacco NtDFR gene. On the other hand, PsMYB44 -silenced P. suffruticosa petals had a redder blotch colour, which was attributed to the fact that silencing PsMYB44 redirected metabolic flux to the anthocyanin biosynthesis branch, thereby promoting more anthocyanin accumulation in the petal base. Conclusion These results demonstrated that PsMYB44 negatively regulated the biosynthesis of anthocyanin by directly binding to the PsDFR promoter and subsequently inhibiting blotch formation, which helped to elucidate the molecular regulatory network of anthocyanin-mediated blotch formation in plants. [ABSTRACT FROM AUTHOR]

Published
2023
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116. A novel nanosilica‐supported ultraviolet absorber for the preparation of robust biodegradable plastic film with high ultraviolet aging resistance

Author

Demin Jia, Bangchao Zhong, Yongjun Chen, Shuli Zhu, Li Qunyang, Zhixin Jia, Dong Xie, Xueqi Zeng, and Tang Yuhan

Subjects
Materials science, Polymers and Plastics, Aging resistance, Materials Chemistry, Ceramics and Composites, medicine, General Chemistry, Composite material, Biodegradable plastic, medicine.disease_cause, Ultraviolet
Published
2019

121. High reactive sulphide chemically supported on silica surface to prepare functional nanoparticle

Author

Xiaohui Guo, Zhixin Jia, Lijuan Chen, Lianghui Wu, Yuanfang Luo, Tang Yuhan, and Demin Jia

Subjects
inorganic chemicals, Materials science, Silicon, General Physics and Astronomy, chemistry.chemical_element, Nanoparticle, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Chemical reaction, law.invention, Natural rubber, law, chemistry.chemical_classification, technology, industry, and agriculture, Vulcanization, Surfaces and Interfaces, General Chemistry, Polymer, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Sulfur, 0104 chemical sciences, Surfaces, Coatings and Films, chemistry, Chemical engineering, visual_art, visual_art.visual_art_medium, 0210 nano-technology, Dispersion (chemistry)
Abstract

A solid-phase preparation method was applied to obtain a novel, green and effective functional nanoparticle, silica-supported sulfur monochloride (silica-s-S2Cl2), by the chemical reaction between chlorine atom and silicon hydroxyl on the silica surface. Through this chemical reaction, silica surface supported with high content of sulfur, and the functional nanoparticles can not only vulcanize the rubber instead of sulfur or other vulcanizing agent with high performance, but also improve the filler-rubber interaction as a modifier due to the improved modification effect. 29Si NMR, Raman spectroscopy, Element analysis and TGA confirm that the sulfur monochloride is chemically bonded on the silica surface. Cure properties measurement, morphology of filler dispersion, mechanical properties measurement, immobilized polymer layer and oxidation induction time increment together show that the novel vulcanizing agent silica-s-S2Cl2 instead of sulfur in rubber vulcanization gives rise to significant improvement in the crosslinking density and the interfacial adhesion between silica particles and the rubber matrix, which is on account of the promoted vulcanizing on the functional silica nanoparticles surface with the supported sulfur.

Published
2018

124. Graph2Plan

Author

Hu, Ruizhen, primary, Huang, Zeyu, additional, Tang, Yuhan, additional, Van Kaick, Oliver, additional, Zhang, Hao, additional, and Huang, Hui, additional

Published
2020
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135. Novel functional silica nanoparticles for rubber vulcanization and reinforcement

Author

Zhixin Jia, Demin Jia, Yuanfang Luo, Tang Yuhan, Lijuan Chen, and Lianghui Wu

Subjects
Materials science, chemistry.chemical_element, Nanoparticle, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, law.invention, Silica nanoparticles, chemistry.chemical_compound, Natural rubber, law, Polymer chemistry, Composite material, Polysulfide, Curing (chemistry), General Engineering, Vulcanization, 021001 nanoscience & nanotechnology, Sulfur, 0104 chemical sciences, Silanol, chemistry, visual_art, Ceramics and Composites, visual_art.visual_art_medium, 0210 nano-technology
Abstract

A high reactive sulfocompound, sulfur monochloride, was chemically supported onto the surface of silica (silica-s-S2Cl2) by the reaction between chloric atom and silanol hydroxyl to obtain a novel vulcanizing agent, silica supported sulfur monochloride (silica-s-S2Cl2). Silica-s-S2Cl2 can be homogeneously dispersed in SBR matrix as a modifier and cure the styrene-butadiene rubber (SBR) without sulfur as a novel high-efficiency vulcanizing agent. The sulfur and Bis[3-(triethoxysilyl)propyl] Tetrasulfide (TESPT) silane coupling agent vulcanized SBR composites were mainly polysulfide crosslinks, on the contrary, the vulcanization by silica-s-S2Cl2 give priority to the mono- and disulfides crosslinks. The highlight of this work lies in the fact that apparent improvement has been achieved by novel and high efficient functional particles due to the silica surface supported with sulfur monochloride, which may open up new opportunities for the preparation of functional nano-fillers in rubber industry.

Published
2017

136. Zucc.) K.Koch (Rosaceae), a Mesic Forest Tree with High Ornamental Potential

Author

Tang, Yuhan, Zhang, Keliang, Zhang, Yin, and Tao, Jun

Subjects
seed dormancy, Sorbus alnifolia, seed germination, soil seed bank, cold stratification, deep physiological dormancy
Abstract

Sorbus alnifolia (Siebold &amp, Zucc.) K.Koch (Rosaceae) is an economically important tree in the temperate forests of Eastern China. In recent decades, ever-increasing use and modification of forestlands have resulted in major degeneration of the natural habitat of S. alnifolia. Moreover, S. alnifolia seeds germinate in a complicated way, leading to a high cost of propagation. The current study aimed to determine the requirements for breaking seed dormancy and for germination as well as to characterize the type of seed dormancy present in this species. Moreover, the roles of temperature, cold/warm stratification, and gibberellic acid (GA3) in breaking dormancy were tested combined with a study of the soil seed bank. The results showed that intact seeds of S. alnifolia were dormant, requiring 150 days of cold stratification to achieve the maximum germination percentage at 5/15 &deg, C. Exposure of the seeds to ranges of temperatures at 15/25 &deg, C and 20/30 &deg, C resulted in secondary dormancy. Scarifying seed coat and partial removal of the cotyledon promoted germination. Compared with long-term cold stratification, one month of warm stratification plus cold stratification was superior in breaking dormancy. Application of GA3 did not break the dormancy during two months of incubation. Seeds of S. alnifolia formed a transient seed bank. The viability of freshly matured S. alnifolia seeds was 87.65% &plusmn, 11.67%, but this declined to 38.25% after 6-months of storage at room temperature. Seeds of S. alnifolia have a deep physiological dormancy, cold stratification will be useful in propagating this species. The long chilling requirements of S. alnifolia seeds would avoid seedling death in winter.

Published
2019
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137. Metabolically healthy obesity increased diabetes incidence in a middle‐aged and elderly Chinese population

Author

Wei, Yue, primary, Wang, Jing, additional, Han, Xu, additional, Yu, Caizheng, additional, Wang, Fei, additional, Yuan, Jing, additional, Miao, Xiaoping, additional, Yao, Ping, additional, Wei, Sheng, additional, Wang, Youjie, additional, Liang, Yuan, additional, Zhang, Xiaomin, additional, Guo, Huan, additional, Zheng, Dan, additional, Tang, Yuhan, additional, Yang, Handong, additional, and He, Meian, additional

Published
2019
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146. Flaxseed Oil Alleviates Chronic HFD-Induced Insulin Resistance through Remodeling Lipid Homeostasis in Obese Adipose Tissue

Author

Yu, Xiao, Tang, Yuhan, Liu, Peiyi, Xiao, Lin, Liu, Liegang, Shen, Ruiling, Deng, Qianchun, and Yao, Ping

Abstract

Emerging evidence suggests that higher circulating long-chain n-3 polyunsaturated fatty acids (n-3PUFA) levels were intimately associated with lower prevalence of obesity and insulin resistance. However, the understanding of bioactivity and potential mechanism of α-linolenic acid-rich flaxseed oil (ALA-FO) against insulin resistance was still limited. This study evaluated the effect of FO on high-fat diet (HFD)-induced insulin resistance in C57BL/6J mice focused on adipose tissue lipolysis. Mice after HFD feeding for 16 weeks (60% fat-derived calories) exhibited systemic insulin resistance, which was greatly attenuated by medium dose of FO (M-FO), paralleling with differential accumulation of ALA and its n-3 derivatives across serum lipid fractions. Moreover, M-FO was sufficient to effectively block the metabolic activation of adipose tissue macrophages (ATMs), thereby improving adipose tissue insulin signaling. Importantly, suppression of hypoxia-inducible factors HIF-1α and HIF-2α were involved in FO-mediated modulation of adipose tissue lipolysis, accompanied by specific reconstitution of n-3PUFA within adipose tissue lipid fractions.

Published
2024
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147. Properties of oil body development and characteristics of OLE gene in herbaceous peony (Paeoinia lactiflora Pall.) seeds.

Author

Meng, Jiasong, Tang, Yuhan, Zhang, Xiayan, Zhao, Daqiu, and Tao, Jun

Subjects
MOLECULAR cloning, SEEDS, ZETA potential, SEED development, ISOELECTRIC point
Abstract

Oil bodies (OBs) are organelles of lipid storage in plants. In order to clarify the properties of OBs development in herbaceous peony (Paeonia lactiflora Pall.) seeds, this research had studied anatomical structures, particle size, zeta potential, the stability of OBs and characteristics of oleosin gene (OLE). It showed that OB particle size increased gradually during seed development, OBs accumulated in the endosperm cells, and their zeta potential firstly decreased and then increased. Temperature had not affected the stability of OBs, they could be maintained stably under the conditions of neutral and alkaline pH and less than 50 mM NaCl. Subsequently, P. lactiflora OLE was isolated, it had 824 bp in full-length and a 435-bp open reading frame encoding 144 amino acids with isoelectric point 9.40, which had three transmembrane domain and did not has a signal peptide, and belonged to the stable protein. Alpha helix was the main part of the secondary structure, no glycosylation site and 14 potential phosphorylation sites were found. Additionally, the express level of OLE initially increased and then decreased, and reached the highest on 60 days after flowering. These results could contribute to understand the properties of OBs development and characteristics of OLE in P. lactiflora seeds. [ABSTRACT FROM AUTHOR]

Published
2020
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148. Association between cancer antigen 19‐9 and diabetes risk: A prospective and Mendelian randomization study.

Author

Li, Zhaoyang, Wang, Jing, Han, Xu, Wang, Fei, Hu, Hua, Yuan, Jing, Yao, Ping, Wei, Sheng, Guo, Huan, Zheng, Dan, Tang, Yuhan, Yang, Handong, and He, Meian

Subjects
SINGLE nucleotide polymorphisms, CANCER associations, PEOPLE with diabetes, DIABETES, ANTIGENS
Abstract

Aims/Introduction: Elevated serum cancer antigen 19‐9 (CA19‐9) levels have been found in diabetes patients in most observational studies; however, whether there is a causal association between CA19‐9 and diabetes mellitus is unclear. Materials and Methods: Our study was carried out based on the Dongfeng‐Tongji cohort comprising 27,009 individuals. We first investigated the associations between serum CA19‐9 levels and incident diabetes mellitus risk in a prospective cohort study (12,700 individuals). Then, we explored the potential causal relationship between CA19‐9 and diabetes mellitus risk in a cross‐sectional study (3,349 diabetes mellitus patients and 8,341 controls) using Mendelian randomization analysis. A weighted genetic risk score was calculated by adding the CA19‐9 increasing alleles in five single‐nucleotide polymorphisms (rs17271883, rs3760776 and rs3760775 in FUT6, rs11880333 in CA11, rs265548 in B3GNT3, and rs1047781 in FUT2), which were identified in a previous genome‐wide association study on serum CA19‐9 levels. Results: In the prospective study, a total of 1,004 incident diabetes mellitus patients were diagnosed during a mean 4.54‐year follow‐up period. Elevated serum CA19‐9 level was associated with a higher incident diabetes risk after adjustment for confounders, with a hazard ratio of 1.20 (95% confidence interval 1.11–1.30) per standard deviation (12.17 U/mL) CA19‐9 increase. Using the genetic score to estimate the unconfounded effect, we did not find a causal association of CA19‐9 with diabetes risk (odds ratio per weighted CA19‐9‐increasing allele: 0.99, 95% confidence interval 0.94–1.04; P = 0.61). Conclusions: The present study did not support a causal association of serum CA19‐9 with diabetes risk. CA19‐9 might be a potential biomarker of incident diabetes mellitus risk. [ABSTRACT FROM AUTHOR]

Published
2020
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150. Serum uric acid levels and decreased estimated glomerular filtration rate in patients with type 2 diabetes: A cohort study and meta-analysis

Author

Wang, Jing, primary, Yu, Yongkai, additional, Li, Xiaowen, additional, Li, Dong, additional, Xu, Chengwei, additional, Yuan, Jing, additional, Wei, Sheng, additional, Li, Xiulou, additional, Yang, Kun, additional, Zheng, Dan, additional, Tang, Yuhan, additional, Yang, Handong, additional, Wu, Tangchun, additional, and He, Meian, additional

Published
2018
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