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1,208 results on '"Taylor, Terrie"'

110. Authors' reply

Author

Plowe, Christopher V, Kublin, James G, Dzinjalamala, Fraction K, Kamwendo, Deborah S, Mukadam, Rabia A G, Chimpeni, Phillips, Molyneux, Malcolm E, and Taylor, Terrie E

Published
2004

118. Determinants of brain swelling in pediatric and adult cerebral malaria

Author

Sahu, Praveen K., primary, Duffy, Fergal J., additional, Dankwa, Selasi, additional, Vishnyakova, Maria, additional, Majhi, Megharay, additional, Pirpamer, Lukas, additional, Vigdorovich, Vladimir, additional, Bage, Jabamani, additional, Maharana, Sameer, additional, Mandala, Wilson, additional, Rogerson, Stephen J., additional, Seydel, Karl B., additional, Taylor, Terrie E., additional, Kim, Kami, additional, Sather, D. Noah, additional, Mohanty, Akshaya, additional, Mohanty, Rashmi R., additional, Mohanty, Anita, additional, Pattnaik, Rajyabardhan, additional, Aitchison, John D., additional, Hoffman, Angelika, additional, Mohanty, Sanjib, additional, Smith, Joseph D., additional, Bernabeu, Maria, additional, and Wassmer, Samuel C., additional

Published
2021
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120. Cerebral Metabolic Crisis in Pediatric Cerebral Malaria

Author

O'Brien, Nicole F., additional, Chetcuti, Karen, additional, Fonseca, Yudy, additional, Vidal, Lorenna, additional, Raghavan, Prashant, additional, Postels, Douglas G., additional, Chimalizeni, Yamikani, additional, Ray, Stephen, additional, Seydel, Karl B., additional, and Taylor, Terrie E., additional

Published
2021
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122. A novel locus of resistance to severe malaria in a region of ancient balancing selection

Author

Band, Gavin, Rockett, Kirk A., Spencer, Chris C.A., Kwiatkowski, Dominic P., Le, Quang Si, Clarke, Geraldine M., Kivinen, Katja, Leffler, Ellen M., Cornelius, Victoria, Conway, David J., Williams, Thomas N., Taylor, Terrie, Bojang, Kalifa A., Doumbo, Ogobara, Thera, Mahamadou A., Modiano, David, Sirima, Sodiomon B., Wilson, Michael D., Koram, Kwadwo A., Agbenyega, Tsiri, Achidi, Eric, Marsh, Kevin, Reyburn, Hugh, Drakeley, Chris, Riley, Eleanor, Molyneux, Malcolm, Jallow, Muminatou, Pinder, Margaret, Toure, Ousmane B., Konate, Salimata, Sissoko, Sibiri, Bougouma, Edith C., Mangano, Valentina D., Amenga-Etego, Lucas N., Ghansah, Anita K., Hodgson, Abraham V.O., Ansong, Daniel, Enimil, Anthony, Evans, Jennifer, Apinjoh, Tobias O., Macharia, Alexander, Ndila, Carolyne M., Newton, Charles, Peshu, Norbert, Uyoga, Sophie, Manjurano, Alphaxard, Kachala, David, Nyirongo, Vysaul, Mead, Daniel, Drury, Eleanor, Auburn, Sarah, Campino, Susana G., MacInnis, Bronwyn, Stalker, Jim, Gray, Emma, Hubbart, Christina, Jeffreys, Anna E., Rowlands, Kate, Mendy, Alieu, Craik, Rachel, Fitzpatrick, Kathryn, Molloy, Sile, Hart, Lee, Hutton, Robert, Kerasidou, Angeliki, and Johnson, Kimberly J.

Published
2015
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125. Brain Swelling and Death in Children with Cerebral Malaria

Author

Seydel, Karl B., Kampondeni, Samuel D., Valim, Clarissa, Potchen, Michael J., Milner, Danny A., Muwalo, Francis W., Birbeck, Gretchen L., Bradley, William G., Fox, Lindsay L., Glover, Simon J., Hammond, Colleen A., Heyderman, Robert S., Chilingulo, Cowles A., Molyneux, Malcolm E., and Taylor, Terrie E.

Published
2015
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128. Cytolytic memory CD4+ T cell clonotypes are expanded during Plasmodium falciparum infection

Author

Furtado, Raquel, primary, Delahaye, Fabien, additional, Zhang, Jinghang, additional, Sung, Joowhan, additional, Karell, Paul, additional, Kim, Ryung S., additional, Caillat-Zucman, Sophie, additional, Liang, Li, additional, Felgner, Philip, additional, Bauleni, Andy, additional, Gama, Syze, additional, Buchwald, Andrea, additional, Taylor, Terrie, additional, Seydel, Karl, additional, Laufer, Miriam, additional, Daily, Johanna P., additional, and Lauvau, Grégoire, additional

Published
2021
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132. Lack of decline in childhood malaria, Malawi, 2001-2010

Author

Roca-Feltrer, Arantxa, Kwizombe, Collins J., Sanjoaquin, Miguel A., Sesay, Sanie S.S., Faragher, Brian, Harrison, Jim, Geukers, Karen, Kabuluzi, Storn, Mathanga, Don P., Molyneux, Elizabeth, Chagomera, Maganizo, Taylor, Terrie, Molyneux, Malcolm, and Heyderman, Robert S.

Subjects
Children -- Health aspects, Malaria -- Control, Health
Abstract

Malaria is a leading cause of illness and death among children in countries in which it is endemic (1). An increasing number of countries in sub-Saharan Africa are rapidly scaling [...]

Published
2012
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133. Time-to-death is a potential confounder in observational studies of blood transfusion in severe malaria

Author

Watson, James A, Leopold, Stije J, Dondorp, Arjen M, White, Nicholas J, Ackerman, Hans, Olola, Christopher HO, Krishna, Sanjeev, Roberts, David J, Kremsner, Peter G, Newton, Charles R, Taylor, Terrie, Valim, Clarissa, and Casals-Pascual, Climent

Subjects
medicine.medical_specialty, Blood transfusion, business.industry, medicine.medical_treatment, Hematology, Time to death, Article, Hospitals, Malaria, Medicine, Potential confounder, Humans, Severe Malaria, Observational study, Blood Transfusion, Prospective Studies, Malaria, Falciparum, business, Intensive care medicine, Child
Published
2020

138. Association of the GNAS locus with severe malaria

Author

Auburn, Sarah, Diakite, Mahamadou, Fry, Andrew E., Ghansah, Anita, Campino, Susana, Richardson, Anna, Jallow, Muminatou, Sisay-Joof, Fatou, Pinder, Margaret, Griffiths, Michael J., Peshu, Norbert, Williams, Thomas N., Marsh, Kevin, Molyneux, Malcolm E., Taylor, Terrie E., Koram, Kwadwo A., Oduro, Abraham R., Rogers, William O., Rockett, Kirk A., Haldar, Kasturi, and Kwiatkowski, Dominic P.

Published
2008
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139. Mechanisms of Transcranial Doppler Ultrasound phenotypes in paediatric cerebral malaria remain elusive.

Author

O'Brien, Nicole F., Fonseca, Yudy, Johnson, Hunter C., Postels, Douglas, Birbeck, Gretchen L., Chimalizeni, Yamikani, Seydel, Karl B., Bernard Gushu, Montfort, Phiri, Tusekile, June, Sylvester, Chetcuti, Karen, Vidal, Lorenna, Goyal, Manu S., and Taylor, Terrie E.

Subjects
TRANSCRANIAL Doppler ultrasonography, CEREBRAL malaria, MAGNETIC resonance imaging, CEREBRAL circulation, PHENOTYPES, CEREBRAL vasospasm
Abstract

Background: Cerebral malaria (CM) results in significant paediatric death and neurodisability in sub-Saharan Africa. Several different alterations to typical Transcranial Doppler Ultrasound (TCD) flow velocities and waveforms in CM have been described, but mechanistic contributors to these abnormalities are unknown. If identified, targeted, TCD-guided adjunctive therapy in CM may improve outcomes. Methods: This was a prospective, observational study of children 6 months to 12 years with CM in Blantyre, Malawi recruited between January 2018 and June 2021. Medical history, physical examination, laboratory analysis, electroencephalogram, and magnetic resonance imaging were undertaken on presentation. Admission TCD results determined phenotypic grouping following a priori definitions. Evaluation of the relationship between haemodynamic, metabolic, or intracranial perturbations that lead to these observed phenotypes in other diseases was undertaken. Neurological outcomes at hospital discharge were evaluated using the Paediatric Cerebral Performance Categorization (PCPC) score. Results: One hundred seventy-four patients were enrolled. Seven (4%) had a normal TCD examination, 57 (33%) met criteria for hyperaemia, 50 (29%) for low flow, 14 (8%) for microvascular obstruction, 11 (6%) for vasospasm, and 35 (20%) for isolated posterior circulation high flow. A lower cardiac index (CI) and higher systemic vascular resistive index (SVRI) were present in those with low flow than other groups (p < 0.003), though these values are normal for age (CI 4.4 [3.7,5] l/min/m2, SVRI 1552 [1197,1961] dscm-5m2). Other parameters were largely not significantly different between phenotypes. Overall, 118 children (68%) had a good neurological outcome. Twenty-three (13%) died, and 33 (19%) had neurological deficits. Outcomes were best for participants with hyperaemia and isolated posterior high flow (PCPC 1–2 in 77 and 89% respectively). Participants with low flow had the least likelihood of a good outcome (PCPC 1–2 in 42%) (p < 0.001). Cerebral autoregulation was significantly better in children with good outcome (transient hyperemic response ratio (THRR) 1.12 [1.04,1.2]) compared to a poor outcome (THRR 1.05 [0.98,1.02], p = 0.05). Conclusions: Common pathophysiological mechanisms leading to TCD phenotypes in non-malarial illness are not causative in children with CM. Alternative mechanistic contributors, including mechanical factors of the cerebrovasculature and biologically active regulators of vascular tone should be explored. [ABSTRACT FROM AUTHOR]

Published
2022
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140. Impact of school-based malaria screening and treatment onP. falciparuminfection and anemia prevalence in two transmission settings in Malawi

Author

Cohee, Lauren M., primary, Peterson, Ingrid, additional, Coalson, Jenna E., additional, Valim, Clarissa, additional, Chilombe, Moses, additional, Ngwira, Andrew, additional, Bauleni, Andy, additional, Schaffer-DeRoo, Sarah, additional, Seydel, Karl B., additional, Wilson, Mark L., additional, Taylor, Terrie E., additional, Mathanga, Don P., additional, and Laufer, Miriam K., additional

Published
2021
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141. Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria

Author

Mejia, Pedro, primary, Treviño-Villarreal, J. Humberto, additional, De Niz, Mariana, additional, Meibalan, Elamaran, additional, Longchamp, Alban, additional, Reynolds, Justin S., additional, Turnbull, Lindsey B., additional, Opoka, Robert O., additional, Roussilhon, Christian, additional, Spielmann, Tobias, additional, Ozaki, C. Keith, additional, Heussler, Volker T., additional, Seydel, Karl B., additional, Taylor, Terrie E., additional, John, Chandy C., additional, Milner, Danny A., additional, Marti, Matthias, additional, and Mitchell, James R., additional

Published
2021
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142. Revisiting Co-trimoxazole Prophylaxis for African Adults in the Era of Antiretroviral Therapy: A Randomized Controlled Clinical Trial

Author

Laurens, Matthew B, primary, Mungwira, Randy G, additional, Nampota, Nginache, additional, Nyirenda, Osward M, additional, Divala, Titus H, additional, Kanjala, Maxwell, additional, Mkandawire, Felix A, additional, Galileya, Lufina Tsirizani, additional, Nyangulu, Wongani, additional, Mwinjiwa, Edson, additional, Downs, Matthew, additional, Tillman, Amy, additional, Taylor, Terrie E, additional, Mallewa, Jane, additional, Plowe, Christopher V, additional, van Oosterhout, Joep J, additional, and Laufer, Miriam K, additional

Published
2021
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144. Additional file 5 of Dimethyl fumarate reduces TNF and Plasmodium falciparum induced brain endothelium activation in vitro

Author

Neida K. Mita-Mendoza, Magallon-Tejada, Ariel, Parmar, Priyanka, Furtado, Raquel, Aldrich, Margaret, Saidi, Alex, Taylor, Terrie, Smith, Joe, Seydel, Karl, and Daily, Johanna P.

Abstract

Additional file 5. Binding specificity of P. falciparum parasites ITgICAM1 and IT4var19 to HBMVEC. A. Binding of ITgICAM1 (DC17) IE to resting and TNF activated HBMVEC is shown as percent binding to HBMVEC relative to unstimulated HBMVEC. Inhibitory antibodies against ICAM1 (mAb15.2) or IgG isotype control were added to HBMVEC monolayers prior to IE cytoadherence. B. Binding of IT4var19 (DC8) IE to resting HBMVEC is shown as percent binding to HBMVEC. Inhibitory antibodies against EPCR (mAb252) or IgG isotype control were added to HBMVEC monolayers prior to IE cytoadherence (n = 3 independent experiments). Results shown were analysed using analysis of variance followed by post-hoc multiple comparisons using Turkey’s test, ***p

Published
2020
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146. Pneumocystis pneumonia in HIV-positive adults, Malawi (1)

Author

van Oosterhout, Joep J.G., Laufer, Miriam K., Perez, M. Arantza, Graham, Stephen M., Chimbiya, Nelson, Thesing, Phillip C., Alvarez-Martinez, Miriam J., Wilson, Paul E., Chagomerana, Maganizo, Zijlstra, Eduard E., Taylor, Terrie E., Plowe, Christopher V., and Meshnick, Steven R.

Subjects
Pneumocystis carinii pneumonia -- Diagnosis, Pneumocystis carinii pneumonia -- Care and treatment, Bacterial infections -- Diagnosis, Bacterial infections -- Care and treatment
Abstract

In a prospective study of 660 HIV-positive Malawian adults, we diagnosed Pneumocystis jirovecii pneumonia (PcP) using clinical features, induced sputum for immunofluorescent staining, real-time PCR, and posttreatment followup. PcP incidence [...]

Published
2007

147. Insights into malaria susceptibility using genome - wide data on 17,000 individuals from Africa, Asia and Oceania

Author

Band, Gavin, Le, Quang Si, Clarke, Geraldine M., Kivinen, Katja, Hubbart, Christina, Jeffreys, Anna E., Rowlands, Kate, Leffler, Ellen M., Jallow, Muminatou, Conway, David J., Sisay-Joof, Fatoumatta, Sirugo, Giorgio, d’Alessandro, Umberto, Toure, Ousmane B., Thera, Mahamadou A., Konate, Salimata, Sissoko, Sibiri, Mangano, Valentina D., Bougouma, Edith C., Sirima, Sodiomon B., Amenga-Etego, Lucas N., Ghansah, Anita K., Hodgson, Abraham V. O., Wilson, Michael D., Enimil, Anthony, Ansong, Daniel, Evans, Jennifer, Ademola, Subulade A., Apinjoh, Tobias O., Ndila, Carolyne M., Manjurano, Alphaxard, Drakeley, Chris, Reyburn, Hugh, Phu, Nguyen Hoan, Ngoc Quyen, Nguyen Thi, Thai, Cao Quang, Hien, Tran Tinh, Teo, Yik Ying, Manning, Laurens, Laman, Moses, Michon, Pascal, Karunajeewa, Harin, Siba, Peter, Allen, Steve, Allen, Angela, Bahlo, Melanie, Davis, Timothy M. E., Cornelius, Victoria, Shelton, Jennifer, Spencer, Chris C.A., Busby, George B.J., Kerasidou, Angeliki, Drury, Eleanor, Stalker, Jim, Dilthey, Alexander, Mentzer, Alexander J., McVean, Gil, Bojang, Kalifa A., Doumbo, Ogobara, Modiano, David, Koram, Kwadwo A., Agbenyega, Tsiri, Amodu, Olukemi K., Achidi, Eric, Williams, Thomas N., Marsh, Kevin, Riley, Eleanor M., Molyneux, Malcolm, Taylor, Terrie, Dunstan, Sarah J., Farrar, Jeremy, Mueller, Ivo, Rockett, Kirk A., Kwiatkowski, Dominic P., HUS Gynecology and Obstetrics, and Wellcome Trust

Subjects
0301 basic medicine, Male, RESISTANCE LOCI, General Physics and Astronomy, Datasets as Topic, Genome-wide association study, Disease, Genome-wide association studies, DISEASE, 0302 clinical medicine, HLA Antigens, BLOOD-GROUP, Prevalence, qu_460, Malaria, Falciparum, Child, lcsh:Science, GENE-EXPRESSION, 11832 Microbiology and virology, Genetics, Multidisciplinary, PLASMODIUM-FALCIPARUM, biology, GENOTYPE, 3. Good health, ALLELE, Cerebral Malaria, Chromosomes, Human, Pair 6, Female, Malaria Genomic Epidemiology Network, Medical genomics, Adult, Asia, Science, Oceania, wa_395, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Article, malaria genomic epidemiology, plasmodium-falciparum, genotype, 03 medical and health sciences, Plasma Membrane Calcium-Transporting ATPases, parasitic diseases, medicine, Immunogenetics, Humans, Genetic Predisposition to Disease, Genetic association, TRANSCRIPTOME ANALYSES, IDENTIFICATION, Case-control study, Plasmodium falciparum, wc_755, General Chemistry, biology.organism_classification, medicine.disease, wc_750, Malaria, ASSOCIATION ANALYSIS, 030104 developmental biology, Infectious disease (medical specialty), Genetic Loci, Case-Control Studies, Africa, lcsh:Q, 3111 Biomedicine, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing of family trios and by direct typing of candidate loci in an additional 15,000 samples. We identify five replicable associations with genome-wide levels of evidence including a newly implicated variant on chromosome 6. Jointly, these variants account for around one-tenth of the heritability of severe malaria, which we estimate as ~23% using genome-wide genotypes. We interrogate available functional data and discover an erythroid-specific transcription start site underlying the known association in ATP2B4, but are unable to identify a likely causal mechanism at the chromosome 6 locus. Previously reported HLA associations do not replicate in these samples. This large dataset will provide a foundation for further research on the genetic determinants of malaria resistance in diverse populations., Four genome-wide associated loci are currently known for malaria susceptibility. Here, the authors expand on earlier work by combining data from 11 malaria-endemic countries and additional population sequencing informing an African-enriched imputation reference panel, with findings including a previously unreported association on chromosome 6.

Published
2019

148. Malaria

Author

Taylor, Terrie, primary and Agbenyega, Tsiri, additional

Published
2013
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149. List of Contributors

Author

Acuin, Jose M, primary, Adam, Rodney D, additional, Agbenyega, Tsiri, additional, Ahmed, AM Shamsir, additional, Ahmed, Tahmeed, additional, Ali, S Asad, additional, Anstead, Gregory M, additional, Armah, George E, additional, Aston, Stephen J, additional, Ballard, Ronald C, additional, Barnett, Elizabeth D, additional, Bates, Imelda, additional, Beadling, Charles W, additional, Beeching, Nicholas J, additional, Bennish, Michael L, additional, Bern, Caryn, additional, Bia, Frank J, additional, Bird, Brian H, additional, Bloom, Allyson K, additional, Bodeker, Gerard, additional, Bradsher, Robert W, additional, Broek, Nynke van den, additional, Brooker, Simon, additional, Brooks, John T, additional, Brooks, W Abdullah, additional, Brouqui, Philippe, additional, Brown, Michael, additional, Bruschi, Fabrizio, additional, Bundy, Donald AP, additional, Bunnag, Danai, additional, Caballero, Benjamin, additional, Callahan, Michael V, additional, Camerlin, Aulasa J, additional, Campbell, Grant L, additional, Carapetis, Jonathan R, additional, Carrol, Enitan D, additional, Caumes, Eric, additional, Charrel, Remi N, additional, Checkley, Anna M, additional, Chhabra, Mala, additional, Chher, Tepirou, additional, Chiong, Charlotte M, additional, Chisti, M Jobayer, additional, Christiani, David C, additional, Connor, Bradley A, additional, Cooper, Edward S, additional, Cooper, Philip J, additional, Coughlin, R Richard, additional, Cross, John H, additional, Cunliffe, Nigel N, additional, Danta, Mark, additional, Day, Nicholas PJ, additional, Dekumyoy, Paron, additional, deSilva, Nilanthi, additional, Deye, Gregory, additional, Dillingham, Rebecca, additional, Doorn, H Rogier van, additional, Doudier, Barbara, additional, Drancourt, Michel, additional, Dromer, Françoise, additional, Eddleston, Michael, additional, El-Kamary, Samer S, additional, Farrar, Jeremy, additional, Fawzi, Wafaie, additional, Feasey, Nicholas A, additional, Field, Vanessa, additional, Fischer, Marc, additional, Fisher-Hoch, Susan, additional, Forsyth, Kevin, additional, Fox, LeAnne M, additional, Friedlander, Arthur M, additional, Galdos-Cardenas, Gerson, additional, Garcia, Hector H, additional, Garcia, Lynne S, additional, Geretti, Anna-Maria, additional, Gikas, Achilleas, additional, Gilman, Robert H, additional, Gonzalez, Victor Javier Sanchez, additional, Gordon, Melita A, additional, Gosselin, Richard A, additional, Graham, Stephen M, additional, Grant, Alison D, additional, Gray, James J, additional, Graybill, John R, additional, Graz, Bertrand, additional, Green, Stephen, additional, Griffiths, Jeffrey K, additional, Gryseels, Bruno, additional, Gubler, Duane J, additional, Guhadasan, Rathi, additional, Hall, Aron J, additional, Hamer, Davidson, additional, Harley, David, additional, Harris, Jason B, additional, Hartman, Amy L, additional, Hassall, Oliver, additional, Hay, Roderick J, additional, Heyns, Chris F, additional, Hill, David R, additional, Hobdell, Martin H, additional, Hoed, Caroline M den, additional, Holtz, Meredith L, additional, Hossain, M Iqbal, additional, Hotez, Peter J, additional, Houpt, Eric R, additional, Howard, Cynthia R, additional, Hung, Chien-Ching, additional, Islam, Munirul, additional, Joekes, Elizabeth, additional, Johnston, Victoria, additional, Kampondeni, Sam, additional, Kang, Gagandeep, additional, Kazanjian, Powel, additional, Keystone, Jay S, additional, Khan, Wasif Ali, additional, Kim, Arthur Y, additional, King, Christopher L, additional, Klion, Amy D, additional, Knight, Richard, additional, Krause, Peter James, additional, Krishna, Sanjeev, additional, Kuipers, Ernst J, additional, LaBeaud, Angelle D, additional, Lalloo, David G, additional, Lamballerie, Xavier De, additional, Lambert, Saba, additional, LaRocque, Regina C, additional, Lawrenson, John, additional, Levine, Myron M, additional, Libraty, Daniel H, additional, Lockwood, Diana NJ, additional, Lommerse, Kinke M, additional, Lortholary, Olivier, additional, López-Vélez, Rogelio, additional, Lopman, Benjamin A, additional, Mabey, David, additional, Magill, Alan J., additional, Maguiña, Ciro, additional, Mahmood, Syed Faisal, additional, Maitland, Kathryn, additional, Manji, Hadi, additional, Marston, Barbara J, additional, Mathew, Anu, additional, Mathews, Christine E, additional, Maurin, Max, additional, Maurtua-Neumann, Paola J, additional, Mayaud, Philippe, additional, Mayosi, Bongani M, additional, McCormick, Joseph B, additional, McKew, Stephen, additional, McLellan, Susan LF, additional, McMinn, Peter C, additional, Mega, Joseph D, additional, Meier, Donald E, additional, Million, Matthieu, additional, Mittal, Veena, additional, Molyneux, Elizabeth M, additional, Montgomery, Susan P, additional, Morera, Pedro, additional, Moro, Pedro L, additional, Moss, William J, additional, Murrell, K Darwin, additional, Nakagomi, Osamu, additional, Nakagomi, Toyoko, additional, Nanda, Neha, additional, Nataro, James P, additional, Navaro, Eileen E, additional, Neafie, Ronald C, additional, Negroni, Ricardo, additional, Nelson, Ann M, additional, Newton, Paul N, additional, Newton, Robert, additional, Nichol, Stuart T, additional, Norman, Francesca F, additional, Nunes, Marcio RT, additional, Nutman, Thomas B, additional, Oberhelman, Richard A, additional, Oldfield, Edward C, additional, Ordaya, Eloy E, additional, Paddock, Christopher D, additional, Paessler, Slobodan, additional, Papanikolaou, Ilias C, additional, Pappas, Georgios, additional, Paris, Luc, additional, Parola, Philippe, additional, Parry, Christopher M, additional, Patel, Manish M, additional, Peacock, Sharon J, additional, Peeling, Rosanna, additional, Persson, Hans, additional, Peters, Philip J, additional, Phillips, Jonathan J, additional, Phillips, Richard O, additional, Qamar, Farah Naz, additional, Rahman, Atif, additional, Rajab, Jamilla, additional, Raoult, Didier, additional, Rein, Michael F, additional, Renvoisé, Aurélié, additional, Reynes, Jean-Marc, additional, Richards, Frank O, additional, Richens, John, additional, Rimoin, Anne W, additional, Riviello, Robert, additional, Rodrigues, Ema G, additional, Ronald, Allan R, additional, Rosenthal, Benjamin M, additional, Rosmarin, David, additional, Ruiz-Tiben, Ernesto, additional, Ryan, Edward T, additional, Saha, Debasish, additional, Saavedra, Arturo, additional, Schantz, Peter M, additional, Schountz, Tony, additional, Schumacher, Sandra K, additional, Sejvar, James J, additional, Sethi, Aisha, additional, Seung, Kwonjune J, additional, Sharma, Om Prakash, additional, Sharp, Trueman W, additional, Shankar, Anuraj H, additional, Shin, Sonya S, additional, Shlim, David R, additional, Sickels, Nicholas J van, additional, Sitas, Freddy, additional, Snelling, Thomas L, additional, Socolovschi, Cristina, additional, Solomon, Tom, additional, Staples, J Erin, additional, Stewart, Robert C, additional, Stich, August, additional, Strickland, G Thomas, additional, Suh, Kathryn N, additional, Suhrbier, Andreas, additional, Supparatpinyo, Khuanchai, additional, Sutcliffe, Catherine G, additional, Swierczewski, Brett E, additional, Tarpley, John L, additional, Taylor, Hugh R, additional, Taylor, Terrie, additional, Thomas, Harry J, additional, Thwaites, C Louise, additional, Thwaites, Guy E, additional, Tiwari, Tejpratap SP, additional, Tu, Phan Van, additional, Turner, Angus W, additional, Vannier, Edouard, additional, Vasconcelos, Pedro FC, additional, Vega-López, Fransisco, additional, Velarde, Jorge J, additional, Vietri, Nicholas J, additional, Visvesvara, Govinda S, additional, Vyas, Keyur S, additional, Wakeham, Katie, additional, Walsh, Thomas J, additional, Wansbrough-Jones, Mark H, additional, Warrell, David A, additional, Warrell, Mary J, additional, Warraich, Haider J, additional, Watt, George, additional, Wattanagoon, Yupaporn, additional, Watthanakulpanich, Dorn, additional, Weaver, Scott C, additional, Webman, Rachel B, additional, Weidle, Paul J, additional, Weiss, Louis M, additional, White, Nicholas J, additional, Whitty, Christopher JM, additional, Woodhall, Dana M, additional, Wright, Stephen G, additional, Xavier, Ramnik J, additional, Xiao, Lihua, additional, Yu, Hongjie, additional, and Zaidi, Anita KM, additional

Published
2013
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150. Return of chloroquine antimalarial efficacy in Malawi

Author

Laufer, Miriam K., Thesing, Phillip C., Eddington, Nicole D., Masonga, Rhoda, Dzinjalamala, Fraction K., Taylor, Terrie E., Takala, Shannon L., and Plowe, Christopher V.

Subjects
Plasmodium falciparum -- Drug therapy, Chloroquine -- Patient outcomes, Antimalarials -- Patient outcomes
Abstract

A randomized clinical trial was conducted involving 210 children with uncomplicated Plasmodium falciparum malaria in Blantyre, Malawi by treating the children either with chloroquine or sulfadoxine-pyrimethamine to assess the antimalarial efficacy of the drug. Chloroquine was again found to be an efficacious treatment for malaria, 12 years after it was withdrawn from use in Malawi.

Published
2006

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