101. High-level quinolone resistance in Neisseria gonorrhoeae: a report of two cases.
- Author
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Tapsall JW, Limnios EA, Thacker C, Donovan B, Lynch SD, Kirby LJ, Wise KA, and Carmody CJ
- Subjects
- 4-Quinolones, Adult, Drug Resistance, Microbial, Fluoroquinolones, Humans, Male, Microbial Sensitivity Tests, Anti-Infective Agents therapeutic use, Gonorrhea drug therapy
- Abstract
Background and Objectives: Fluoroquinolones are widely used oral agents for treating Neisseria gonorrhoeae. Resistance to these agents is sporadic and usually at a low level. Two instances of high-dose ciprofloxacin regimens failing in the treatment of gonococcal infection, caused by strains with high-level quinolone resistance, are reported., Study Design: This is a case report., Conclusion: High-level resistance to quinolone antibiotics resulting in treatment failure was observed in two distinct gonococcal isolates from patients infected in the Philippines (ciprofloxacin; minimal inhibitory contribution = 16 mg/l). Continued monitoring of the quinolone sensitivity of Neisseria gonorrhoeae is appropriate and prudent.
- Published
- 1995
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