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103 results on '"Thomas M. Connolly"'

101. Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels.

Author

Zhi-Qiang Yang, James C. Barrow, William D. Shipe, Kelly-Ann S. Schlegel, Youheng Shu, F. Vivien Yang, Craig W. Lindsley, Kenneth E. Rittle, Mark G. Bock, George D. Hartman, Victor N. Uebele, Cindy E. Nuss, Steve V. Fox, Richard L. Kraus, Scott M. Doran, Thomas M. Connolly, Cuyue Tang, Jeanine E. Ballard, Yuhsin Kuo, and Emily D. Adarayan

Published
2008
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102. Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+Channel Antagonist.

Author

William D. Shipe, James C. Barrow, Zhi-Qiang Yang, Craig W. Lindsley, F. Vivien Yang, Kelly-Ann S. Schlegel, Youheng Shu, Kenneth E. Rittle, Mark G. Bock, George D. Hartman, Cuyue Tang, Jeanine E. Ballard, Yuhsin Kuo, Emily D. Adarayan, Thomayant Prueksaritanont, Matthew M. Zrada, Victor N. Uebele, Cindy E. Nuss, Thomas M. Connolly, and Scott M. Doran

Published
2008
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103. Increased Sodium-Lithium Countertransport in Red Cells of Patients with Essential Hypertension

Author

Thomas M. Connolly, Norma Adragna, Mitzy Canessa, Harold S. Solomon, and D. C. Tosteson

Subjects
Male, medicine.medical_specialty, Erythrocytes, Lithium (medication), Sodium, chemistry.chemical_element, In Vitro Techniques, Lithium, Essential hypertension, Internal medicine, medicine, Humans, In patient, business.industry, Erythrocyte Membrane, Sodium lithium countertransport, Biological Transport, General Medicine, Water-Electrolyte Balance, medicine.disease, Increased sodium, Endocrinology, chemistry, Hypertension, Potassium, Female, business, medicine.drug
Abstract

This paper describes experiments showing that one of the pathways of sodium transport across the red-cell membrane, sodium-lithium countertransport, is faster in patients with essential hypertension than in control subjects. This transport system accepts only sodium or lithium and is not inhibited by ouabain. The maximum rate of transport shows inherited differences. The mean maximum rate of sodium-lithium countertransport was found to be 0.55 +/- 0.02 (mean +/- S.E.M.) mmol (liter of red cells X hour)(-1) in a group of 36 patients with essential hypertension and 0.24 +/- 0.02 in 26 control subjects (P less than 0.001). The first-degree relatives of eight patients with essential hypertension and 10 control subjects had mean maximum rates of sodium-lithium countertransport of 0.54 +/- 0.05 and 0.23 +/- 0.02, respectively. Five patients with secondary hypertension had normal mean maximum rates of sodium-lithium countertransport. The relation between heritability of red-cell sodium-lithium countertransport and essential hypertension should be investigated further.

Published
1980
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