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Peripheral arterial disease is one of the most frequent clinical manifestations of atherosclerotic disease. The clinical picture of critical ischemia of the lower limbs is often burdened by high mortality and the risk of limb amputation. The direct and indirect prostanoids, and in particular iloprost and cilostazol, are effective in the medical treatment of peripheral arterial disease. We describe here five clinical cases in which iloprost and cilostazol have been successfully administered in arterial patients with various concomitant cardiovascular diseases, highlighting a good safety profile in relation to the cardiocascular risk profile (Cardiology).

Connected Vehicle research has emerged as one of the highest priorities in the transportation systems because connected vehicle technology has the potential to improve safety, mobility, and environment for the current transportation systems. Various connected vehicle based applications have been identified and evaluated through various measurements to assess the performance of connected vehicle applications. However, most of these previous studies have used hypothetical study areas with simple networks for connected vehicle environment. This study represents connected vehicle environment in TRANSIMS to assess the performance of V2V communication applications in the realistic urban network. The communication duration rate and spatial-temporal dispersion of equipped vehicles are investigated to evaluate the capability of V2V communication based on the market penetration rate of equipped vehicles and wireless communication coverage in the whole study area. The area coverage level is used to assess the spatial-temporal dispersion of equipped vehicles for two study areas. The distance of incident information propagation and speed estimation error are used to measure the performance of event-driven and periodic applications based on different market penetration rates of equipped vehicles and wireless communication coverage in both morning peak and non-peak times. The wireless communication coverage is the major factor for event-driven application and the market penetration rate of equipped vehicles has more impact on the performance of periodic application. The required minimum levels of deployment for each application are determined for each scenario. These study findings will be useful for making decisions about investments on deployment of connected vehicle applications to improve the current transportation systems. Notably, event-driven applications can be reliably deployed in the initial stage of deployment despite the low level of market penetration of equipped vehi

A nationwide model predicts the annual county-to-county person roundtrips for air taxi, commercial airline, and automobile at 1-year intervals through 2030. The transportation systems analysis model (TSAM) uses the four-step transportation systems modeling process to calculate trip generation, trip distribution, and mode choice for each county origin–destination pair. Network assignment is formulated for commercial airline and air taxi demand. TSAM classifies trip rates by trip purpose, household income group, and type of metropolitan statistical area from which the round-trip started. A graphical user interface with geographic information systems capability is included in the model. Potential applications of the model are nationwide impact studies of transportation policies and technologies, such as those envisioned with the introduction of extensive air taxi service using very light jets, the next-generation air transportation system, and the introduction of new aerospace technologies.

An airport is an important piece of infrastructure in air transportation system. This project focuses on measuring and ranking the efficiency of airports in the United States using the basic DEA, Ranking DEA, Goal programming and DEA and TOPSIS. In general, airport authorities of relatively inefficient airports are trying to benchmark the operational strategies of efficient airports. This project focuses on evaluating hub airports in the United States. ATL, LAX, and MEM airports are relatively efficient among forty four hub airports in the United States based on the performances and airport facilities of the 2000 year when the results of all applied methods in this project, the basic DEA ranking, the Cross Efficiency ranking, the Andersen-Petersen ranking and TOPSIS ranking method, are compared. The implication of this project is that airport authorities in the United States would benchmark these three airports to maximize operation and management efficiency for their airports. In general, most of the airports are handling passengers and freight. Therefore, ATL and LAX would be the most efficient hub airports in the United States. The capacities of airport facilities and more appropriate input data like financial data should be considered in the follow up research.

A new safety application, as part of ITS Advanced Rural Transportation System (ARTS), has been developed to be deployed on a two-lane rural road (Route 114), in Southwest Virginia. The route segment under study is subject to significant head-on accidents, as a result of two main conditions: 1- Illegal passing maneuvers crossing solid yellow line, and 2- A short passing sight distance due to the road vertical profile. The main objective of this research is to design a video detection-based warning system by installing an affordable and efficient system on the vertical crest curve on Route 114, capable of performing the following two main functions: 1.Detect vehicles that attempt to violate the no-passing zone restriction (i.e. when crossing into the opposing direction). 2.Warn the drivers violating the restriction in order to discourage them from continuing their maneuvers. System architecture as well as detailed system design was developed. A system simulation was conducted with the use of a special software program written with MATLAB. The simulation was applied for both "with" and "without" the system cases. The simulation runs showed that the system could virtually eliminate all head-on collisions, should violators obey the early warning messages displayed. Several sensitivity tests were made for different scenarios. Finally, the viability of the system was evaluated from economic point of view. The financial analysis revealed high economic indicators.