926 results on '"VAN DER POST, JORIS A."'
Search Results
102. Study protocol for a randomised trial for atosiban versus placebo in threatened preterm birth: The APOSTEL 8 study
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Projectafdeling ALS, JC onderzoeksprogramma Methodologie, Epi Methoden Team 1, Epi Methoden Team 4, Arts-assistenten DV&B, Klumper, Job, Breebaart, Wouter, Roos, Carolien, Naaktgeboren, Christiana A., Van Der Post, Joris, Bosmans, Judith, Van Kaam, Anton, Schuit, Ewoud, Mol, Ben W., Baalman, Jelle, McAuliffe, Fionnuala, Thornton, Jim, Kok, Marjolein, Oudijk, Martijn A., Projectafdeling ALS, JC onderzoeksprogramma Methodologie, Epi Methoden Team 1, Epi Methoden Team 4, Arts-assistenten DV&B, Klumper, Job, Breebaart, Wouter, Roos, Carolien, Naaktgeboren, Christiana A., Van Der Post, Joris, Bosmans, Judith, Van Kaam, Anton, Schuit, Ewoud, Mol, Ben W., Baalman, Jelle, McAuliffe, Fionnuala, Thornton, Jim, Kok, Marjolein, and Oudijk, Martijn A.
- Published
- 2019
103. Microparticle subpopulations are increased in preeclampsia: Possible involvement in vascular dysfunction?
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VanWijk, Marja J., Nieuwland, Rienk, Boer, Kees, van der Post, Joris A.M., VanBavel, Ed, and Sturk, Augueste
- Published
- 2002
104. Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'
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de Milliano Inge, Tabbers Merit M, van der Post Joris A, and Benninga Marc A
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Probiotics ,Constipation ,Pregnancy ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background Constipation during pregnancy is a common problem. Nowadays only few effective interventions are published preventing or treating constipation during pregnancy. However, their use is limited due to side-effects. This uncontrolled intervention study was performed to determine if a mixture of probiotics in the treatment of constipation during pregnancy is effective. Methods Women aged ≥ 18 years with functional constipation were included at the Obstetrical outpatient clinic and midwife practices. Patients received during four weeks a daily dose of Ecologic®Relief (Bifidobacterium bifidum W23, Bifidobacterium lactis W52, Bifidobacterium longum W108, Lactobacillus casei W79, Lactobacillus plantarum W62 and Lactobacillus rhamnosus W71 (total 4*109 CFU)). For all analyses, the non-parametric paired Wilcoxon test was used. Primary outcome measure was change in defecation frequency. Secondary outcome measures were stool consistency, sensation of incomplete evacuation, sensation of anorectal obstruction, manual manoeuvres to facilitate defecation, abdominal pain, adverse effects, presence of reflux episodes and intake of Bisacodyl. Results 20 women were included. Defecation frequency significantly increased from 3.1 at baseline to 6.7 in week four (p Conclusions Ecologic®Relief is effective in the treatment of constipation during pregnancy. A randomised placebo controlled trial is required to confirm these data.
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- 2012
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105. Correction: Pessaries in multiple pregnancy as a prevention of preterm birth: the ProTwin Trial
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Liem Sophie MS, Bekedam Dick J, Bloemenkamp Kitty WM, Kwee Anneke, Papatsonis Dimitri NM, van der Post Joris AM, Lim Arianne C, Scheepers Hubertina CJ, Willekes Christine, Duvekot Johannes J, Spaanderman Marc, Porath Martina, van Eyck Jim, Haak Monique C, van Pampus Marielle G, Bruinse Hein W, Mol Ben Willem J, and Hegeman Maud A
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Gynecology and obstetrics ,RG1-991 - Published
- 2012
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106. Integrale geboortezorg - Reactie Oei et al
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Goodarzi, Bahareh, Van der Post, Joris A. M., Schellevis, FG, de Jonge, J, Midwifery Science, Amsterdam Reproduction & Development (AR&D), APH - Quality of Care, General practice, APH - Aging & Later Life, and APH - Personalized Medicine
- Published
- 2018
107. Integrale geboortezorg - Reactie Nijhuis
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Goodarzi, Bahareh, Van der Post, Joris A. M., Schellevis, FG, de Jonge, Ank, Midwifery Science, General practice, APH - Quality of Care, Amsterdam Reproduction & Development (AR&D), APH - Aging & Later Life, and APH - Personalized Medicine
- Published
- 2018
108. Invoering integrale geboortezorg voorbarig
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Goodarzi, Bahareh, de Jonge, Ank, Van der Post, Joris A. M., Schellevis, F.G., Midwifery Science, Amsterdam Reproduction & Development (AR&D), APH - Quality of Care, General practice, APH - Aging & Later Life, and APH - Personalized Medicine
- Abstract
Vijftig jaar geleden kreeg integrale geboortezorg geen groen licht, vanwege onvoldoende wetenschappelijk bewijs. Dat bewijs is er nog steeds niet. Toch krijgt deze organisatievorm nu wél vrij baan. Gedegen onderzoek vooraf zou op zijn plaats zijn, stellen Bahareh Goodarzi en collega’s.
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- 2018
109. Induction of labour at 41 weeks versus expectant management until 42 weeks (INDEX): multicentre, randomised non-inferiority trial
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Keulen, Judit KJ, primary, Bruinsma, Aafke, additional, Kortekaas, Joep C, additional, van Dillen, Jeroen, additional, Bossuyt, Patrick MM, additional, Oudijk, Martijn A, additional, Duijnhoven, Ruben G, additional, van Kaam, Anton H, additional, Vandenbussche, Frank PHA, additional, van der Post, Joris AM, additional, Mol, Ben Willem, additional, and de Miranda, Esteriek, additional
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- 2019
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110. 586: Posttraumatic stress disorder in partners of patients following severe postpartum hemorrhage
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van Steijn, Minouk E., primary, Scheepstra, Karel W., additional, Zaat, Tjitske R., additional, van der Post, Joris A., additional, Olff, Miranda, additional, and van Pampus, Maria G., additional
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- 2019
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111. Well being of obstetric patients on minimal blood transfusions (WOMB trial)
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Bloemenkamp Kitty WM, Schippers Daniela H, Spaanderman Marc EA, Rijnders Robbert JP, Porath Martina, van Alphen Marcel, van der Post Joris AM, Stigter Rob H, van Loon Aren J, Bremer Henk A, Metz Godfried CH, Akerboom Bettina MC, Papatsonis Dimitri NM, Uyl-de Groot Carin A, Peters Nina CJ, Essink-Bot Marie-Louise, Hop Wim CJ, Jansen AJ Gerard, Steegers Eric AP, Prick Babette W, Boers Kim E, Scheepers Hubertina CJ, Roumen Frans JME, Kwee Anneke, Schuitemaker Nico WE, Mol Ben Willem J, van Rhenen Dick J, and Duvekot Johannes J
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Primary postpartum haemorrhage is an obstetrical emergency often causing acute anaemia that may require immediate red blood cell (RBC) transfusion. This anaemia results in symptoms such as fatigue, which may have major impact on the health-related quality of life. RBC transfusion is generally thought to alleviate these undesirable effects although it may cause transfusion reactions. Moreover, the postpartum haemoglobin level seems to influence fatigue only for a short period of time. At present, there are no strict transfusion criteria for this specific indication, resulting in a wide variation in postpartum policy of RBC transfusion in the Netherlands. Methods/Design The WOMB trial is a multicentre randomised non-inferiority trial. Women with acute anaemia due to postpartum haemorrhage, 12-24 hours after delivery and not initially treated with RBC transfusion, are eligible for randomisation. Patients with severe physical complaints are excluded. Patients are randomised for either RBC transfusion or expectant management. Health related quality of life (HRQoL) will be assessed at inclusion, at three days and one, three and six weeks postpartum with three validated measures (Multi-dimensional Fatigue Inventory, ShortForm-36, EuroQol-5D). Primary outcome of the study is physical fatigue three days postpartum. Secondary outcome measures are general and mental fatigue scores and generic health related quality of life scores, the number of RBC transfusions, length of hospital stay, complications and health-care costs. The primary analysis will be by intention-to-treat. The various longitudinal scores will be evaluated using Repeated Measurements ANOVA. A costs benefit analysis will also be performed. The power calculation is based on the exclusion of a difference in means of 1.3 points or greater in favour of RBC transfusion arm regarding physical fatigue subscale. With missing data not exceeding 20%, 250 patients per arm have to be randomised (one-sided alpha = 0.025, power = 80%). Discussion This study will provide evidence for a guideline regarding RBC transfusion in the postpartum patient suffering from acute anaemia. Equivalence in fatigue score, remaining HRQoL scores and physical complications between both groups is assumed, in which case an expectant management would be preferred to minimise transfusion reactions and costs. Trial registration ClinicalTrials.gov NCT00335023, Nederlands Trial Register NTR335
- Published
- 2010
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112. Cost-effectiveness of recurrence risk guided care versus care as usual in women who suffered from early-onset preeclampsia including HELLP syndrome in their previous pregnancy (the PreCare study)
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de Wit-Zuurendonk Laura D, Bruinse Hein W, Spaanderman Marc E, Peeters Louis L, Sep Simone JS, Dirksen Carmen D, van Kuijk Sander MJ, Delahaije Denise HJ, van der Post Joris AM, Duvekot Johannes J, van Eyck Jim, van Pampus Mariëlle G, van der Hoeven Mark ABHM, and Smits Luc J
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Preeclampsia and HELLP syndrome may have serious consequences for both mother and fetus. Women who have suffered from preeclampsia or the HELLP syndrome, have an increased risk of developing preeclampsia in a subsequent pregnancy. However, most women will develop no or only minor complications. In this study, we intend to determine cost-effectiveness of recurrence risk guided care versus care as usual in pregnant women with a history of early-onset preeclampsia. Methods/design We developed a prediction model to estimate the individual risk of recurrence of early-onset preeclampsia and the HELLP syndrome. In a before-after study, pregnant women with preeclampsia or HELLP syndrome in their previous pregnancy receiving care as usual (before introduction of the prediction model) will be compared with women receiving recurrence risk guided care (after introduction of the prediction model). Eligible and pregnant women will be recruited at six university hospitals and seven large non-university tertiary referral hospitals in the Netherlands. The primary outcome measure is the recurrence of early-onset preeclampsia or HELLP syndrome in women allocated to the regular monitoring group. For the economic evaluation, a modelling approach will be used. Costs and effects of recurrence risk guided care with those of care as usual will be compared by means of a decision model. Two incremental cost-effectiveness ratios will be calculated: 1) cost per Quality Adjusted Life Year (mother unit of analysis) and 2) cost per live born child (child unit of analysis). Discussion This is, to our knowledge, the first study that evaluates prospectively the efficacy of a multivariable prediction rule for recurrent hypertensive disease in pregnancy. Results of this study could either be integrated into the current guideline on Hypertensive Disorders in Pregnancy, or be used to develop a new guideline.
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- 2010
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113. 10-Year cardiovascular event risks for women who experienced hypertensive disorders in late pregnancy: the HyRAS study
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Ponjee Gabrielle, Porath Martina, van der Post Joris A, Bloemenkamp Kitty W, van Pampus Maria G, Franx Arie, Hermes Wietske, Tamsma Jouke T, Mol Ben W, and de Groot Christianne J
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Cardiovascular disease is the cause of death in 32% of women in the Netherlands. Prediction of an individual's risk for cardiovascular disease is difficult, in particular in younger women due to low sensitive and specific tests for these women. 10% to 15% of all pregnancies are complicated by hypertensive disorders, the vast majority of which develop only after 36 weeks of gestation. Preeclampsia and cardiovascular disease in later life show both features of "the metabolic syndrome" and atherosclerosis. Hypertensive disorders in pregnancy and cardiovascular disease may develop by common pathophysiologic pathways initiated by similar vascular risk factors. Vascular damage occurring during preeclampsia or gestational hypertension may contribute to the development of future cardiovascular disease, or is already present before pregnancy. At present clinicians do not systematically aim at the possible cardiovascular consequences in later life after a hypertensive pregnancy disorder at term. However, screening for risk factors after preeclampsia or gestational hypertension at term may give insight into an individual's cardiovascular risk profile. Methods/Design Women with a history of preeclampsia or gestational hypertension will be invited to participate in a cohort study 2 1/2 years after delivery. Participants will be screened for established modifiable cardiovascular risk indicators. The primary outcome is the 10-year cardiovascular event risk. Secondary outcomes include differences in cardiovascular parameters, SNP's in glucose metabolism, and neonatal outcome. Discussion This study will provide evidence on the potential health gains of a modifiable cardiovascular risk factor screening program for women whose pregnancy was complicated by hypertension or preeclampsia. The calculation of individual 10-year cardiovascular event risks will allow identification of those women who will benefit from primary prevention by tailored interventions, at a relatively young age. Trial registration The HYPITAT trial is registered in the clinical trial register as ISRCTN08132825.
- Published
- 2010
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114. Implementation of the external cephalic version in breech delivery. Dutch national implementation study of external cephalic version
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Papatsonis Dimitri N, Kuppens Simone MI, Bais Joke MJ, Akerboom Bettina MC, Haak Monique C, Beuckens Antje, Rijnders Marlies EB, Fleuren Margot AH, Rosman Ageeth N, Vlemmix Floortje, Opmeer Brent C, van der Post Joris AM, Mol Ben Willem J, and Kok Marjolein
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Breech presentation occurs in 3 to 4% of all term pregnancies. External cephalic version (ECV) is proven effective to prevent vaginal breech deliveries and therefore it is recommended by clinical guidelines of the Royal Dutch Organisation for Midwives (KNOV) and the Dutch Society for Obstetrics and Gynaecology (NVOG). Implementation of ECV does not exceed 50 to 60% and probably less. We aim to improve the implementation of ECV to decrease maternal and neonatal morbidity and mortality due to breech presentations. This will be done by defining barriers and facilitators of implementation of ECV in the Netherlands. An innovative implementation strategy will be developed based on improved patient counselling and thorough instructions of health care providers for counselling. Method/design The ultimate purpose of this implementation study is to improve counselling of pregnant women and information of clinicians to realize a better implementation of ECV. The first phase of the project is to detect the barriers and facilitators of ECV. The next step is to develop an implementation strategy to inform and counsel pregnant women with a breech presentation, and to inform and educate care providers. In the third phase, the effectiveness of the developed implementation strategy will be evaluated in a randomised trial. The study population is a random selection of midwives and gynaecologists from 60 to 100 hospitals and practices. Primary endpoints are number of counselled women. Secondary endpoints are process indicators, the amount of fetes in cephalic presentation at birth, complications due to ECV, the number of caesarean sections and perinatal condition of mother and child. Cost effectiveness of the implementation strategy will be measured. Discussion This study will provide evidence for the cost effectiveness of a structural implementation of external cephalic versions to reduce the number of breech presentations at term. Trial Registration Dutch Trial Register (NTR): 1878
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- 2010
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115. Assessment of perinatal outcome after sustained tocolysis in early labour (APOSTEL-II trial)
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Scherjon Sicco A, van der Post Joris AM, Porath Martina M, Papatsonis Dimitri NM, van Pampus Mariëlle G, Opmeer Brent C, Merién Ashley, Kwee Anneke, Kok Joke H, van Eyck Jim, Duvekot Hans JJ, Derks Jan B, Cornette Jerome, Bolte Annemiek, Bloemenkamp Kitty WM, Scheepers Liesbeth HCJ, Roos Carolien, Sollie Krystyne, Spaanderman Marc EA, Vijgen Sylvia MC, Willekes Christine, Mol Ben, and Lotgering Fred K
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Preterm labour is the main cause of perinatal morbidity and mortality in the Western world. At present, there is evidence that tocolysis for 48 hours is useful in women with threatened preterm labour at least before 32 weeks. This allows transfer of the patient to a perinatal centre, and maximizes the effect of corticosteroids for improved neonatal survival. It is questionable whether treatment with tocolytics should be maintained after 48 hours. Methods/Design The APOSTEL II trial is a multicentre placebo-controlled study. Pregnant women admitted for threatened preterm labour who have been treated with 48 hours corticosteroids and tocolysis will be eligible to participate in the trial between 26+0 and 32+2 weeks gestational age. They will be randomly allocated to nifedipine (intervention) or placebo (control) for twelve days or until delivery, whatever comes first. Primary outcome is a composite of perinatal death, and severe neonatal morbidity up to evaluation at 6 months after birth. Secondary outcomes are gestational age at delivery, number of days in neonatal intensive care and total days of the first 6 months out of hospital. In addition a cost-effectiveness analysis will be performed. Analysis will be by intention to treat. The power calculation is based on an expected 11% difference in adverse neonatal outcome. This implies that 406 women have to be randomised (two sided test, β 0.2 at alpha 0.05). Discussion This trial will provide evidence as to whether maintenance tocolysis reduces severe perinatal morbidity and mortality in women with threatened preterm labour before 32 weeks. Trial Registration Clinical trial registration: http://www.trialregister.nl, NTR 1336, date of registration: June 3rd 2008.
- Published
- 2009
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116. Cost-effectiveness of fibronectin testing in a triage in women with threatened preterm labor: alleviation of pregnancy outcome by suspending tocolysis in early labor (APOSTEL-I trial)
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Scherjon Sicco A, Lotgering Fred K, van Pampus Maria G, Opmeer Brent C, Kwee Anneke, van Eyck Jim, Duvekot Johannes J, Derks Jan B, Cornette Jérôme, Bolte Annemiek C, Bloemenkamp Kitty WM, Scheepers Hubertina CJ, Porath Martina M, Oudijk Martijn A, Wilms Femke F, Vis Jolande Y, Sollie Krystyna M, Spaanderman Marc EA, Willekes Christine, van der Post Joris AM, and Mol Ben
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background At present, women with threatened preterm labor before 32 weeks of gestation are, after transfer to a perinatal center, treated with tocolytics and corticosteroids. Many of these women are treated unnecessarily. Fibronectin is an accurate predictor for the occurrence of preterm birth among women with threatened preterm labor. We will assess whether triage of these women with fibronectin testing, cervical length or their combination is cost-effective. Methods/Design We will investigate a prospective cohort of women referred to a perinatal centre for spontaneous threatened preterm labor between 24 and 34 weeks with intact membranes. All women will be tested for fibronectin and cervical length. Women with a cervical length 30 mm will be managed according to local protocol. Corticosteroids may be given to all women at the discretion of the attending physician. Primary outcome measure will be delivery within 7 days. Secondary outcome measures will be neonatal morbidity and mortality, complications of tocolytics, costs and health related quality of life. The analysis will be according to the intention to treat principle. We anticipate the probability on preterm birth within 7 days in the group of women with a negative fibronectine test to be 5%. Two groups of 110 women will be needed to assure that in case of non-inferiority the difference in the proportion of preterm deliveries < 7 days will be within a prespecified boundary of 7.5% (one sided test, β 0.2, α 0.05). Data obtained from women with a positive and negative fibronectin tests in both the cohort study and the trial will be integrated in a cost-effectiveness analysis that will assess economic consequences of the use of fibronectin. Discussion This study will provide evidence for the use of fibronectin testing as safe and cost-effective method in a triage for threatened preterm labor. Trial registration Nederlands Trial Register (NTR) number 1857, http://www.trialregister.nl.
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- 2009
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117. Pessaries in multiple pregnancy as a prevention of preterm birth: the ProTwin Trial
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Porath Martina, Spaanderman Marc, Duvekot Johannes J, Willekes Christine, Scheepers Hubertina CJ, Lim Arianne C, van der Post Joris AM, Papatsonis Dimitri NM, Kwee Anneke, Bloemenkamp Kitty WM, Bekedam Dick J, Hegeman Maud A, van Eyck Jim, Haak Monique C, van Pampus Marielle G, Bruinse Hein W, and Mol Ben Willem J
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Multiple pregnancies are at high risk for preterm birth, and therefore an important cause of infant mortality and morbidity. A pessary is a simple and potentially effective measure for the prevention of preterm birth. Small studies have indicated its effectiveness, but large studies with sufficient power on the subject are lacking. Despite this lack of evidence, the treatment is at present applied by some gynaecologists in The Netherlands. Methods/Design We aim to investigate the hypothesis that prophylactic use of a cervical pessary will be effective in the prevention of preterm delivery and the neonatal mortality and morbidity resulting from preterm delivery in multiple pregnancy. We will evaluate the costs and effects of this intervention. At study entry, cervical length will be measured. Eligible women will be randomly allocated to receive either a cervical pessary or no intervention. The cervical pessary will be placed in situ at 16 to 20 weeks, and will stay in situ up to 36 weeks gestation or until delivery, whatever comes first. The primary outcome is composite bad neonatal condition (perinatal death or severe morbidity). Secondary outcome measures are time to delivery, preterm birth rate before 32 and 37 weeks, days of admission in neonatal intensive care unit, maternal morbidity, maternal admission days for preterm labour and costs. We need to include 660 women to indicate a reduction in bad neonatal outcome from 7.2% without to 3.9% with a cervical pessary, using a two-sided test with an alpha of 0.05 and a power of 0.80. Discussion This trial will provide evidence on whether a cervical pessary will decrease the incidence of early preterm birth and its concomitant bad neonatal outcome in multiple pregnancies. Trial registration Current Controlled Trials: NTR 1858
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- 2009
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118. Can flow cytometric detection of platelet activation early in pregnancy predict the occurrence of preeclampsia? A prospective study
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Konijnenberg, Alice, van der Post, Joris A.M., Mol, Ben W., Schaap, Marianne C.L., Lazarov, Risto, Bleker, Otto P., Boer, Kees, and Sturk, Augueste
- Published
- 1997
119. Extensive platelet activation in preeclampsia compared with normal pregnancy: Enhanced expression of cell adhesion molecules
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Konijnenberg, Alice, Stokkers, Els W., van der Post, Joris A.M., Schaap, Marianne C.L., Boer, Kees, Bleker, Otto P., and Sturk, Augueste
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- 1997
120. Serum screening with Down's syndrome markers to predict pre-eclampsia and small for gestational age: Systematic review and meta-analysis
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Langejans Marloes, Cnossen Jeltsje S, Morris Rachel K, Robson Stephen C, Kleijnen Jos, ter Riet Gerben, Mol Ben W, van der Post Joris AM, and Khan Khalid S
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Reliable antenatal identification of pre-eclampsia and small for gestational age is crucial to judicious allocation of monitoring resources and use of preventative treatment with the prospect of improving maternal/perinatal outcome. The purpose of this systematic review was to determine the accuracy of five serum analytes used in Down's serum screening for prediction of pre-eclampsia and/or small for gestational age. Methods The data sources included Medline, Embase, Cochrane library, Medion (inception to February 2007), hand searching of relevant journals, reference list checking of included articles, contact with experts. Two reviewers independently selected the articles in which the accuracy of an analyte used in Downs's serum screening before the 25th gestational week was associated with the occurrence of pre-eclampsia and/or small for gestational age without language restrictions. Two authors independently extracted data on study characteristics, quality and results. Results Five serum screening markers were evaluated. 44 studies, testing 169,637 pregnant women (4376 pre-eclampsia cases) and 86 studies, testing 382,005 women (20,339 fetal growth restriction cases) met the selection criteria. The results showed low predictive accuracy overall. For pre-eclampsia the best predictor was inhibin A>2.79MoM positive likelihood ratio 19.52 (8.33,45.79) and negative likelihood ratio 0.30 (0.13,0.68) (single study). For small for gestational age it was AFP>2.0MoM to predict birth weight < 10th centile with birth < 37 weeks positive likelihood ratio 27.96 (8.02,97.48) and negative likelihood ratio 0.78 (0.55,1.11) (single study). A potential clinical application using aspirin as a treatment is given as an example. There were methodological and reporting limitations in the included studies thus studies were heterogeneous giving pooled results with wide confidence intervals. Conclusion Down's serum screening analytes have low predictive accuracy for pre-eclampsia and small for gestational age. They may be a useful means of risk assessment or of use in prediction when combined with other tests.
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- 2008
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121. The fourth sound of Korotkoff in pregnancy: a myth?
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Franx, Arie, van der Post, Joris A. M., van Montfrans, Gert A., Bruinse, Hein W., and Visser, Gerard H. A.
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- 1996
122. Platelet response to vasopressin in preeclampsia
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van der Post, Joris, Konijnenberg, Alice, and Sturk, Auguste
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- 1995
123. Disproportionate Intrauterine Growth Intervention Trial At Term: DIGITAT
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Huisjes Anjoke JM, van der Salm Paulien CM, Drogtrop Addie P, Ribbert Lucy SM, Bekedam Dick J, van der Post Joris AM, van Meir Claudia A, Bloemenkamp Kitty WM, Stigter Rob H, van Pampus Marielle G, Birnie Erwin, LeCessie Saskia, Mol Ben WJ, Bijlenga Denise, Boers Kim E, Willekes Christine, Roumen Frans JME, Scheepers Hubertina CJ, de Boer Karin, Duvekot Johannes J, Thornton Jim G, and Scherjon Sicco A
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Around 80% of intrauterine growth restricted (IUGR) infants are born at term. They have an increase in perinatal mortality and morbidity including behavioral problems, minor developmental delay and spastic cerebral palsy. Management is controversial, in particular the decision whether to induce labour or await spontaneous delivery with strict fetal and maternal surveillance. We propose a randomised trial to compare effectiveness, costs and maternal quality of life for induction of labour versus expectant management in women with a suspected IUGR fetus at term. Methods/design The proposed trial is a multi-centre randomised study in pregnant women who are suspected on clinical grounds of having an IUGR child at a gestational age between 36+0 and 41+0 weeks. After informed consent women will be randomly allocated to either induction of labour or expectant management with maternal and fetal monitoring. Randomisation will be web-based. The primary outcome measure will be a composite neonatal morbidity and mortality. Secondary outcomes will be severe maternal morbidity, maternal quality of life and costs. Moreover, we aim to assess neurodevelopmental and neurobehavioral outcome at two years as assessed by a postal enquiry (Child Behavioral Check List-CBCL and Ages and Stages Questionnaire-ASQ). Analysis will be by intention to treat. Quality of life analysis and a preference study will also be performed in the same study population. Health technology assessment with an economic analysis is part of this so called Digitat trial (Disproportionate Intrauterine Growth Intervention Trial At Term). The study aims to include 325 patients per arm. Discussion This trial will provide evidence for which strategy is superior in terms of neonatal and maternal morbidity and mortality, costs and maternal quality of life aspects. This will be the first randomised trial for IUGR at term. Trial registration Dutch Trial Register and ISRCTN-Register: ISRCTN10363217.
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- 2007
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124. Induction of labour versus expectant monitoring in women with pregnancy induced hypertension or mild preeclampsia at term: the HYPITAT trial
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Mol Ben WJ, van Loon Aren J, le Cessie Saskia, Kwee Anneke, Huisjes Anjoke JM, de Groot Christianne JM, Franx Arie, Drogtrop Addi P, Bloemenkamp Kitty WM, Birnie Erwin, Burggraaff Jan M, van den Berg Paul P, Bekedam Dick J, van Beek Erik, Aarnoudse Jan G, Bijlenga Denise, Koopmans Corine M, van der Post Joris AM, Roumen Frans JME, Scheepers Hubertina CJ, Spaanderman Marc EA, Stigter Rob H, Willekes Christine, and van Pampus Maria G
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Hypertensive disorders, i.e. pregnancy induced hypertension and preeclampsia, complicate 10 to15% of all pregnancies at term and are a major cause of maternal and perinatal morbidity and mortality. The only causal treatment is delivery. In case of preterm pregnancies conservative management is advocated if the risks for mother and child remain acceptable. In contrast, there is no consensus on how to manage mild hypertensive disease in pregnancies at term. Induction of labour might prevent maternal and neonatal complications at the expense of increased instrumental vaginal delivery rates and caesarean section rates. Methods/Design Women with a pregnancy complicated by pregnancy induced hypertension or mild preeclampsia at a gestational age between 36+0 and 41+0 weeks will be asked to participate in a multi-centre randomised controlled trial. Women will be randomised to either induction of labour or expectant management for spontaneous delivery. The primary outcome of this study is severe maternal morbidity, which can be complicated by maternal mortality in rare cases. Secondary outcome measures are neonatal mortality and morbidity, caesarean and vaginal instrumental delivery rates, maternal quality of life and costs. Analysis will be by intention to treat. In total, 720 pregnant women have to be randomised to show a reduction in severe maternal complications of hypertensive disease from 12 to 6%. Discussion This trial will provide evidence as to whether or not induction of labour in women with pregnancy induced hypertension or mild preeclampsia (nearly) at term is an effective treatment to prevent severe maternal complications. Trial Registration The protocol is registered in the clinical trial register number ISRCTN08132825.
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- 2007
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125. Development and internal validation of a clinical prediction model for external cephalic version
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Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, Epi Methoden Team 1, Velzel, Joost, Schuit, Ewoud, Vlemmix, Floortje, Molkenboer, Jan F.M., Van der Post, Joris A.M., Mol, Ben W., Kok, Marjolein, Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, Epi Methoden Team 1, Velzel, Joost, Schuit, Ewoud, Vlemmix, Floortje, Molkenboer, Jan F.M., Van der Post, Joris A.M., Mol, Ben W., and Kok, Marjolein
- Published
- 2018
126. Cardiovascular biochemical risk factors among women with spontaneous preterm delivery
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Arts-assistenten DV&B, MS Verloskunde, Brain, Child Health, Circulatory Health, Cardiologie, Team Medisch, Heida, Karst Y., Kampman, Marlies A., Franx, Arie, De Laat, Monique W., Mulder, Barbara J., Van der Post, Joris A., Bilardo, Catia M., Pieper, Petronella G., Sollie, Krystyna M., Sieswerda, Gertjan T., Ris-Stalpers, Carrie, Oudijk, Martijn A., Arts-assistenten DV&B, MS Verloskunde, Brain, Child Health, Circulatory Health, Cardiologie, Team Medisch, Heida, Karst Y., Kampman, Marlies A., Franx, Arie, De Laat, Monique W., Mulder, Barbara J., Van der Post, Joris A., Bilardo, Catia M., Pieper, Petronella G., Sollie, Krystyna M., Sieswerda, Gertjan T., Ris-Stalpers, Carrie, and Oudijk, Martijn A.
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- 2018
127. Prediction of pre-eclampsia: a protocol for systematic reviews of test accuracy
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Khan Khalid S, Mol Ben WJ, van der Post Joris AM, Cnossen Jeltsje S, Meads Catherine A, and ter Riet Gerben
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Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Pre-eclampsia, a syndrome of hypertension and proteinuria, is a major cause of maternal and perinatal morbidity and mortality. Accurate prediction of pre-eclampsia is important, since high risk women could benefit from intensive monitoring and preventive treatment. However, decision making is currently hampered due to lack of precise and up to date comprehensive evidence summaries on estimates of risk of developing pre-eclampsia. Methods/Design A series of systematic reviews and meta-analyses will be undertaken to determine, among women in early pregnancy, the accuracy of various tests (history, examinations and investigations) for predicting pre-eclampsia. We will search Medline, Embase, Cochrane Library, MEDION, citation lists of review articles and eligible primary articles and will contact experts in the field. Reviewers working independently will select studies, extract data, and assess study validity according to established criteria. Language restrictions will not be applied. Bivariate meta-analysis of sensitivity and specificity will be considered for tests whose studies allow generation of 2 × 2 tables. Discussion The results of the test accuracy reviews will be integrated with results of effectiveness reviews of preventive interventions to assess the impact of test-intervention combinations for prevention of pre-eclampsia.
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- 2006
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128. Preeclampsia Is Not Associated With Altered Platelet Vasopressin Binding and Cytosolic Ca++ Concentration
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van der Post, Joris A. M., Konijnenberg, Alice, Boer, Kees, Schaap, Marian C. L., van Boxtel, Christine E. A., Sturk, Augueste, Boer, Gerard J., and Swaab, Dick F.
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- 1993
129. Fetal monitoring indications for delivery and 2-year outcome in 310 infants with fetal growth restriction delivered before 32 weeks' gestation in the TRUFFLE study
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Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Ferrazzi, E., Fratelli, Nicola, Frusca, T., Ganzevoort, W., Lees, Christoph C., Napolitano, Raffaele, Todros, T., Wolf, H., Hecher, K., Marlow, N., Arabin, B., Brezinka, C., Diemert, A., Duvekot, Johannes J., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Thilaganathan, B., Valcamonico, A., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., van Haastert, I. C., Kingdom, J.C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Marsal, K., Maurer-Fellbaum, Ute, Mensing van Charante, N., Mulder-De Tollenaer, Susanne, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Prefumo, Federico, Preston, Lucy, Raimondi, Francesco, and Rattue, H.
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ductus venosus ,fetal growth restriction ,Radiological and Ultrasound Technology ,Reproductive Medicine ,Radiology Nuclear Medicine and imaging ,Obstetrics and Gynaecology ,Journal Article ,cardiotocography ,preterm delivery ,fetal heart rate variation - Abstract
Objective: In the TRUFFLE (Trial of Randomized Umbilical and Fetal Flow in Europe) study on the outcome of early fetal growth restriction, women were allocated to one of three groups of indication for delivery according to the following monitoring strategies: (1) reduced fetal heart rate (FHR) short-term variation (STV) on cardiotocography (CTG); (2) early changes in fetal ductus venosus (DV) waveform (DV-p95); and (3) late changes in fetal DV waveform (DV-no-A). However, many infants per monitoring protocol were delivered because of safety-net criteria, for maternal or other fetal indications, or after 32 weeks of gestation when the protocol was no longer applied. The objective of the present posthoc subanalysis was to investigate the indications for delivery in relation to 2-year outcome in infants delivered before 32 weeks to further refine management proposals. Methods: We included all 310 cases of the TRUFFLE study with known outcome at 2 years' corrected age and seven fetal deaths, excluding seven cases with inevitable perinatal death. Data were analyzed according to the allocated fetal monitoring strategy in combination with the indication for delivery. Results: Overall, only 32% of liveborn infants were delivered according to the specified monitoring parameter for indication for delivery; 38% were delivered because of safety-net criteria, 15% for other fetal reasons and 15% for maternal reasons. In the CTG-STV group, 51% of infants were delivered because of reduced STV. In the DV-p95 group, 34% of infants were delivered because of abnormal DV and, in the DV-no-A group, only 10% of infants were delivered accordingly. The majority of infants in the DV groups were delivered for the safety-net criterion of spontaneous decelerations in FHR. Two-year intact survival was highest in the DV groups combined compared with the CTG-STV group (P = 0.05 for live births only, P = 0.21 including fetal death), with no difference between DV groups. A poorer outcome in the CTG-STV group was restricted to infants delivered because of FHR decelerations in the safety-net subgroup. Infants delivered because of maternal reasons had the highest birth weight and a non-significantly higher intact survival. Conclusions: In this subanalysis of infants delivered before 32 weeks, the majority were delivered for reasons other than the allocated monitoring strategy indication. Since, in the DV group, CTG-STV criteria were used as a safety net but in the CTG-STV group, no DV safety-net criteria were applied, we speculate that the slightly poorer outcome in the CTG-STV group might be explained by the absence of DV data. The optimal timing of delivery of fetuses with early intrauterine growth restriction may therefore be best determined by monitoring them longitudinally, with both DV and CTG monitoring.
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- 2017
130. How to monitor pregnancies complicated by fetal growth restriction and delivery before 32 weeks : post-hoc analysis of TRUFFLE study
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Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, and on behalf of the TRUFFLE Group
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ductus venosus ,fetal growth restriction ,intrauterine growth restriction ,Radiological and Ultrasound Technology ,Reproductive Medicine ,Radiology Nuclear Medicine and imaging ,Obstetrics and Gynaecology ,Journal Article ,cardiotocography - Abstract
Objectives: In the recent TRUFFLE study, it appeared that, in pregnancies complicated by fetal growth restriction (FGR) between 26 and 32 weeks' gestation, monitoring of the fetal ductus venosus (DV) waveform combined with computed cardiotocography (CTG) to determine timing of delivery increased the chance of infant survival without neurological impairment. However, concerns with the interpretation were raised, as DV monitoring appeared to be associated with a non-significant increase in fetal death, and some infants were delivered after 32 weeks, at which time the study protocol no longer applied. This secondary sensitivity analysis of the TRUFFLE study focuses on women who delivered before 32 completed weeks' gestation and analyzes in detail the cases of fetal death. Methods: Monitoring data of 317 pregnancies with FGR that delivered before 32 weeks were analyzed, excluding those with absent outcome data or inevitable perinatal death. Women were allocated randomly to one of three groups of indication for delivery according to the following monitoring strategies: (1) reduced fetal heart rate short-term variation (STV) on CTG; (2) early changes in fetal DV waveform; and (3) late changes in fetal DV waveform. Primary outcome was 2-year survival without neurological impairment. The association of the last monitoring data before delivery and infant outcome was assessed by multivariable analysis. Results: Two-year survival without neurological impairment occurred more often in the two DV groups (both 83%) than in the CTG-STV group (77%), however, the difference was not statistically significant (P = 0.21). Among the surviving infants in the DV groups, 93% were free of neurological impairment vs 85% of surviving infants in the CTG-STV group (P = 0.049). All fetal deaths (n = 7) occurred in the groups with DV monitoring. Of the monitoring parameters obtained shortly before fetal death in these seven cases, an abnormal CTG was observed in only one case. Multivariable regression analysis of factors at study entry demonstrated that a later gestational age, higher estimated fetal weight-to-50th percentile ratio and lower umbilical artery pulsatility index (PI)/fetal middle cerebral artery-PI ratio were significantly associated with normal outcome. Allocation to DV monitoring had a smaller effect on outcome, but remained in the model (P < 0.1). Abnormal fetal arterial Doppler before delivery was significantly associated with adverse outcome in the CTG-STV group. In contrast, abnormal DV flow was the only monitoring parameter associated with adverse outcome in the DV groups, while fetal arterial Doppler, STV below the cut-off used in the CTG-STV group and recurrent decelerations in fetal heart rate were not. Conclusions: In accordance with the findings of the TRUFFLE study on monitoring and intervention management of very preterm FGR, we found that the proportion of infants surviving without neuroimpairment was not significantly different when the decision for delivery was based on changes in DV waveform vs reduced STV on CTG. The uneven distribution of fetal deaths towards the DV groups was probably a chance effect, and neurological outcome was better among surviving children in these groups. Before 32 weeks, delaying delivery until abnormalities in DV-PI or STV and/or recurrent decelerations in fetal heat rate occur, as defined by the study protocol, is likely to be safe and possibly benefits long-term outcome.
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- 2017
131. Intrapartum epidural analgesia and low Apgar score among singleton infants born at term: A propensity score matched study.
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Ravelli, Anita C. J., Eskes, Martine, Groot, Christianne J. M., Abu‐Hanna, Ameen, Post, Joris A. M., de Groot, Christianne J M, Abu-Hanna, Ameen, and van der Post, Joris A M
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PROPENSITY score matching ,EPIDURAL analgesia ,APGAR score ,INTENSIVE care units ,NEONATAL intensive care ,DURATION of pregnancy ,MATERNAL age ,LABOR (Obstetrics) ,PROBABILITY theory - Abstract
Introduction: The associations of epidural analgesia and low Apgar score found in the Swedish Registry might be a result of confounding by indication. The objective of this study was to assess the possible effect of intrapartum epidural analgesia on low Apgar score and neonatal intensive care unit (NICU) admission in term born singletons with propensity score matching.Material and Methods: This was a propensity score matched study (n = 257 872) conducted in a national cohort of 715 449 term live born singletons without congenital anomalies in the Netherlands. Mothers with prelabor cesarean section were excluded. Main outcome measures were 5-minute Apgar score <7, 5-minute Apgar score <4 and admission to a NICU for at least 24 hours. First, an analysis of the underlying risk factors for low Apgar score <7 was performed. Multivariable analyses were applied to assess the effect of the main risk factor, intrapartum epidural analgesia, on low Apgar score to adjust the results for confounding factors. Second, a propensity score matched analysis on the main risk factors for epidural analgesia was applied. By propensity score matching the (confounding) characteristics of the women who received epidural analgesia with the characteristics of the control women without epidural analgesia, the effect of possible confounding by indication is minimized.Results: Intrapartum epidural analgesia was performed in 128 936 women (18%). Apgar score <7 was present in 1.0%, Apgar score <4 in .2% and NICU admission in .4% of the deliveries. The strongest risk factor for Apgar score <7 was epidural analgesia (adjusted odds ratio [aOR] 1.9, 95% confidence interval [CI] 1.8-2.0). The propensity score matched adjusted analysis of women with epidural analgesia showed significant adverse neonatal outcomes: aOR 1.8 (95% CI 1.7-1.9) for AS <7, aOR 1.6 (95% CI 1.4-1.9) for AS <4 and aOR 1.7 (95% CI 1.6-1.9) for NICU admission. The results of epidural analgesia on AS <7 were also significantly increased for spontaneous start of labor (aOR 2.0, 95% CI 1.8-2.1) and for spontaneous delivery.Conclusions: Intrapartum epidural analgesia at term is strongly associated with low Apgar score and more NICU admissions, especially in spontaneous deliveries. This association needs further research and awareness. [ABSTRACT FROM AUTHOR]- Published
- 2020
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132. Intrapartum and neonatal mortality in low-risk term women in midwife-led care and obstetrician-led care at the onset of labor: A national matched cohort study.
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Wiegerinck, Melanie M. J., Eskes, Martine, Post, Joris A. M., Mol, Ben W., Ravelli, Anita C. J., and van der Post, Joris A M
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BIRTHING centers ,NEONATAL mortality ,UTERINE rupture ,WOMEN'S mortality ,CESAREAN section ,PROPENSITY score matching ,COHORT analysis ,FETAL death - Abstract
Introduction: Midwife-led models of care have been the subject of debate for many years. We conducted a study to compare intrapartum and neonatal mortality rates in midwife-led (primary) vs obstetrician-led (secondary) care at the onset of labor in low-risk term women.Material and Methods: We performed an unmatched and a propensity score matched cohort study using data from the national perinatal audit registry (PAN) and from the national perinatal registry (PERINED) of the Netherlands. We included women with singleton pregnancies (without congenital anomalies or antepartum fetal death) who gave birth at term between 2010 and 2012. We excluded the following major risk factors: non-vertex position of the fetus, previous cesarean birth, hypertension, diabetes mellitus, prolonged rupture of membranes (≥24 hours), vaginal bleeding in the second half of pregnancy, nonspontaneous start of labor and post-term pregnancy (≥42 weeks). The primary outcome was intrapartum or neonatal mortality up to 28 days after birth. Secondary outcome measures were mode of delivery and a 5-minute Apgar score <7.Results: We included 259 211 women. There were 100/206 642 (0.48‰) intrapartum and neonatal deaths in the midwife group and 23/52 569 (0.44‰) in the obstetrician group (odds ratio [OR] 1.11, 95% CI 0.70-1.74). Propensity score matched analysis showed mortality rates of 0.49‰ (26/52 569) among women in midwife-led care and 0.44‰ (23/52 569) for women in obstetrician-led care (OR 1.13, 95% CI 0.65-1.98). In the midwife group there were significantly lower rates of vaginal instrumental deliveries (8.4% vs 13.0%; matched OR 0.65, 95% CI 0.62-0.67) and intrapartum cesarean sections (2.6% vs 8.2%; matched OR 0.32, 95% CI 0.30-0.34), and fewer neonates with low Apgar scores (<7 after 5 minutes) (0.69% vs 1.11%; matched OR 0.61, 95% CI 0.53-0.69).Conclusions: Among low-risk term women, there were comparable intrapartum and neonatal mortality rates for women starting labor in midwife-led vs obstetrician-led care, with lower intervention rates and fewer low Apgar scores in the midwife group. [ABSTRACT FROM AUTHOR]- Published
- 2020
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133. 362. Transient blindness out off the uterus, reported by Nicolaes Tulp in 1641
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Bleker, Otto Pieter, primary, Ganzevoort, Wessel, additional, and van der Post, Joris, additional
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- 2018
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134. In silico analysis of the Mus musculus uterine gene expression landscape during pregnancy identifies putative upstream regulators for labour
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Fernando, Febilla, primary, Boussata, Souad, additional, Jongejan, Aldo, additional, van der Post, Joris A., additional, Afink, Gijs, additional, and Ris-Stalpers, Carrie, additional
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- 2018
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135. Usability and Usefulness of a Mobile Health App for Pregnancy-Related Work Advice: Mixed-Methods Approach (Preprint)
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van Beukering, Monique, primary, Velu, Adeline, additional, van den Berg, Liesbeth, additional, Kok, Marjolein, additional, Mol, Ben Willem, additional, Frings-Dresen, Monique, additional, de Leeuw, Robert, additional, van der Post, Joris, additional, and Peute, Linda, additional
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- 2018
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136. Cardiovascular biochemical risk factors among women with spontaneous preterm delivery
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Heida, Karst Y., primary, Kampman, Marlies A., additional, Franx, Arie, additional, De Laat, Monique W., additional, Mulder, Barbara J., additional, Van der Post, Joris A., additional, Bilardo, Catia M., additional, Pieper, Petronella G., additional, Sollie, Krystyna M., additional, Sieswerda, Gertjan T., additional, Ris-Stalpers, Carrie, additional, and Oudijk, Martijn A., additional
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- 2018
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137. Genetic Analyses in Small-for-Gestational-Age Newborns
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Stalman, Susanne E, primary, Solanky, Nita, additional, Ishida, Miho, additional, Alemán-Charlet, Cristina, additional, Abu-Amero, Sayeda, additional, Alders, Marielle, additional, Alvizi, Lucas, additional, Baird, William, additional, Demetriou, Charalambos, additional, Henneman, Peter, additional, James, Chela, additional, Knegt, Lia C, additional, Leon, Lydia J, additional, Mannens, Marcel M A M, additional, Mul, Adi N, additional, Nibbering, Nicole A, additional, Peskett, Emma, additional, Rezwan, Faisal I, additional, Ris-Stalpers, Carrie, additional, van der Post, Joris A M, additional, Kamp, Gerdine A, additional, Plötz, Frans B, additional, Wit, Jan M, additional, Stanier, Philip, additional, Moore, Gudrun E, additional, and Hennekam, Raoul C, additional
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- 2018
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138. Intrapartum and neonatal mortality among low-risk women in midwife-led versus obstetrician-led care in the Amsterdam region of the Netherlands: a propensity score matched study
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Wiegerinck, Melanie M J, primary, van der Goes, Birgit Y, additional, Ravelli, Anita C J, additional, van der Post, Joris A M, additional, Buist, Fayette C D, additional, Tamminga, Pieter, additional, and Mol, Ben W, additional
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- 2018
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139. 157: Severe postpartum hemorrhage causes posttraumatic disorder in women
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van Steijn, Minouk E., primary, Zaat, Tjitske R., additional, Scheepstra, Karel W., additional, van der Post, Joris A., additional, Olff, Miranda, additional, and van Pampus, Maria G., additional
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- 2018
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140. 2 Year Neurodevelopmental and Intermediate Perinatal Outcomes in Infants With Very Preterm Fetal Growth Restriction (TRUFFLE): A Randomised Trial
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Lees, Christoph C., Marlow, Neil, Van Wassenaer-Leemhuis, Aleid, Arabin, Birgit, Bilardo, Caterina M., Brezinka, Christoph, Calvert, Sandra, Derks, Jan B., Diemert, Anke, Duvekot, Johannes J., Ferrazzi, Enrico, Frusca, Tiziana, Ganzevoort, Wessel, Hecher, Kurt, Martinelli, Pasquale, Ostermayer, Eva, Papageorghiou, Aris T., Schlembach, Dietmar, Schneider, K. T M, Thilaganathan, Baskaran, Todros, Tullia, Valcamonico, Adriana, Visser, Gerard H A, Wolf, Hans, Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, Van Eyck, Jim, Fratelli, Nicola, Van Haastert, Inge Lot, Lobmaier, Silvia, Lopriore, Enrico, Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Van Charante, Nico Mensing, De Tollenaer, Susanne Mulder, Napolitano, Raffaele, Oberto, Manuela, Oepkes, Dick, Ogge, Giovanna, Van Der Post, Joris, Prefumo, Federico, Preston, Lucy, Raimondi, Francesco, Reiss, Irwin K M, Scheepers, H. C J, Schuit, Ewoud, Skabar, Aldo, Spaanderman, Marc, Weisglas-Kuperus, Nynke, Zimmermann, Andrea, Moore, Tamanna, Johnson, Samantha, Rigano, Serena, Other Research, Neonatology, Other departments, Amsterdam Public Health, Obstetrics and Gynaecology, Obstetrics and gynaecology, Reproductive Origins of Adult Health and Disease (ROAHD), RS: GROW - Developmental Biology, RS: GROW - R4 - Reproductive and Perinatal Medicine, Obstetrie & Gynaecologie, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), APH - Amsterdam Public Health, ARD - Amsterdam Reproduction and Development, Christoph C., Lee, Neil, Marlow, Aleid van Wassenaer, Leemhui, Birgit, Arabin, Caterina M., Bilardo, Christoph, Brezinka, Sandra, Calvert, Jan B., Derk, Anke, Diemert, Johannes J., Duvekot, Enrico, Ferrazzi, Tiziana, Frusca, Wessel, Ganzevoort, Kurt, Hecher, Martinelli, Pasquale, Eva, Ostermayer, Aris T., Papageorghiou, Dietmar, Schlembach, K. T. M., Schneider, Baskaran, Thilaganathan, Tullia, Todro, Adriana, Valcamonico, Gerard H. A., Visser, Hans, Wolf, for the TRUFFLE study, group, Borgione, Silvia, Fratelli, Nicola, Lobmaier, Silvia, Lopriore, Enrico, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Napolitano, Raffaele, Oberto, Manuela, Prefumo, Federico, Raimondi, Francesco, Rigano, Serena, and Obstetrics & Gynecology
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Male ,Percentile ,Pediatrics ,Cardiotocography ,CHILDREN ,Umbilical Arteries ,law.invention ,Primary outcome ,Randomized controlled trial ,Heart Rate ,law ,Central Nervous System Diseases ,Pregnancy ,Fetal growth ,Clinical endpoint ,Prenatal ,GESTATION ,Child ,PREDICTORS ,Non-U.S. Gov't ,Ultrasonography ,Medicine(all) ,Fetal Growth Retardation ,medicine.diagnostic_test ,Medicine (all) ,Research Support, Non-U.S. Gov't ,Pregnancy Outcome ,Obstetrics and Gynecology ,Gestational age ,Pulsed ,General Medicine ,Heart Rate, Fetal ,Very preterm ,Neonatal morbidity ,DOPPLER ,Europe ,Multicenter Study ,PREECLAMPSIA ,Ultrasonography, Doppler, Pulsed ,Child, Preschool ,Infant, Extremely Premature ,Randomized Controlled Trial ,Gestation ,Female ,Gestational Age ,Humans ,Infant, Newborn ,Ultrasonography, Prenatal ,INTERVENTION ,Ductus venosus ,Human ,Reversed flow ,medicine.medical_specialty ,Extremely Premature ,Research Support ,PARAMETERS ,Fetal ,AGE ,HEART-RATE VARIATION ,SDG 3 - Good Health and Well-being ,medicine ,Journal Article ,Preschool ,Fetus ,Intention-to-treat analysis ,business.industry ,RETARDED FETUSES ,Infant ,Newborn ,medicine.disease ,Umbilical Arterie ,Central Nervous System Disease ,business - Abstract
No consensus exists for the best way to monitor and when to trigger delivery in mothers of babies with fetal growth restriction. We aimed to assess whether changes in the fetal ductus venosus Doppler waveform (DV) could be used as indications for delivery instead of cardiotocography short-term variation (STV). In this prospective, European multicentre, unblinded, randomised study, we included women with singleton fetuses at 26-32 weeks of gestation who had very preterm fetal growth restriction (ie, low abdominal circumference [ 95th percentile]). We randomly allocated women 1:1:1, with randomly sized blocks and stratified by participating centre and gestational age ( 95th percentile; DV p95), or late DV changes (A wave [the deflection within the venous waveform signifying atrial contraction] at or below baseline; DV no A). The primary outcome was survival without cerebral palsy or neurosensory impairment, or a Bayley III developmental score of less than 85, at 2 years of age. We assessed outcomes in surviving infants with known outcomes at 2 years. We did an intention to treat study for all participants for whom we had data. Safety outcomes were deaths in utero and neonatal deaths and were assessed in all randomly allocated women. This study is registered with ISRCTN, number 56204499. Between Jan 1, 2005 and Oct 1, 2010, 503 of 542 eligible women were randomly allocated to monitoring groups (166 to CTG STV, 167 to DV p95, and 170 to DV no A). The median gestational age at delivery was 30·7 weeks (IQR 29·1-32·1) and mean birthweight was 1019 g (SD 322). The proportion of infants surviving without neuroimpairment did not differ between the CTG STV (111 [77%] of 144 infants with known outcome), DV p95 (119 [84%] of 142), and DV no A (133 [85%] of 157) groups (ptrend=0·09). 12 fetuses (2%) died in utero and 27 (6%) neonatal deaths occurred. Of survivors, more infants where women were randomly assigned to delivery according to late ductus changes (133 [95%] of 140, 95%, 95% CI 90-98) were free of neuroimpairment when compared with those randomly assigned to CTG (111 [85%] of 131, 95% CI 78-90; p=0.005), but this was accompanied by a non-significant increase in perinatal and infant mortality. Although the difference in the proportion of infants surviving without neuroimpairment was non-significant at the primary endpoint, timing of delivery based on the study protocol using late changes in the DV waveform might produce an improvement in developmental outcomes at 2 years of age. ZonMw, The Netherlands and Dr Hans Ludwig Geisenhofer Foundation, Germany
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- 2015
141. Low dose aspirin in the prevention of recurrent spontaneous preterm labour - the APRIL study : A multicenter randomized placebo controlled trial
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Visser, Laura, de Boer, Marjon A., de Groot, Christianne J.M., Nijman, Tobias A.J., Hemels, Marieke A.C., Bloemenkamp, Kitty W.M., Bosmans, Judith E., Kok, Marjolein, van Laar, Judith O., Sueters, Marieke, Scheepers, Hubertina, van Drongelen, Joris, Franssen, Maureen T.M., Sikkema, J. Marko, Duvekot, Hans J.J., Bekker, Mireille N., van der Post, Joris A.M., Naaktgeboren, Christiana, Mol, Ben W.J., Oudijk, Martijn A., Visser, Laura, de Boer, Marjon A., de Groot, Christianne J.M., Nijman, Tobias A.J., Hemels, Marieke A.C., Bloemenkamp, Kitty W.M., Bosmans, Judith E., Kok, Marjolein, van Laar, Judith O., Sueters, Marieke, Scheepers, Hubertina, van Drongelen, Joris, Franssen, Maureen T.M., Sikkema, J. Marko, Duvekot, Hans J.J., Bekker, Mireille N., van der Post, Joris A.M., Naaktgeboren, Christiana, Mol, Ben W.J., and Oudijk, Martijn A.
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- 2017
142. Which Factors Contribute to False-Positive, False-Negative, and Invalid Results in Fetal Fibronectin Testing in Women with Symptoms of Preterm Labor?
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Bruijn, Merel M C, Hermans, Frederik J R, Vis, Jolande Y., Wilms, Femke F., Oudijk, Martijn A., Kwee, Anneke, Porath, Martina M., Oei, Guid, Scheepers, Hubertina C. J., Spaanderman, Marc E. A., Bloemenkamp, Kitty W M, Haak, Monique C., Bolte, Antoinette C., Vandenbussche, Frank P. H. A., Woiski, Mallory D, Bax, Caroline J., Cornette, Jérôme M J, Duvekot, Johannes J., Bijvank, Bas W A N I J, van Eyck, Jim, Franssen, Maureen T. M., Sollie, Krystyna M., van der Post, Joris A. M., Bossuyt, Patrick M. M., Kok, Marjolein, Mol, Ben Willem J., van Baaren, Gert-Jan, Bruijn, Merel M C, Hermans, Frederik J R, Vis, Jolande Y., Wilms, Femke F., Oudijk, Martijn A., Kwee, Anneke, Porath, Martina M., Oei, Guid, Scheepers, Hubertina C. J., Spaanderman, Marc E. A., Bloemenkamp, Kitty W M, Haak, Monique C., Bolte, Antoinette C., Vandenbussche, Frank P. H. A., Woiski, Mallory D, Bax, Caroline J., Cornette, Jérôme M J, Duvekot, Johannes J., Bijvank, Bas W A N I J, van Eyck, Jim, Franssen, Maureen T. M., Sollie, Krystyna M., van der Post, Joris A. M., Bossuyt, Patrick M. M., Kok, Marjolein, Mol, Ben Willem J., and van Baaren, Gert-Jan
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- 2017
143. Low dose aspirin in the prevention of recurrent spontaneous preterm labour - the APRIL study: A multicenter randomized placebo controlled trial
- Author
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MS Verloskunde, Geboortecentrum voorzitterschap, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Child Health, Epi Methoden Team 1, JC onderzoeksprogramma Methodologie, Visser, Laura, de Boer, Marjon A., de Groot, Christianne J.M., Nijman, Tobias A.J., Hemels, Marieke A.C., Bloemenkamp, Kitty W.M., Bosmans, Judith E., Kok, Marjolein, van Laar, Judith O., Sueters, Marieke, Scheepers, Hubertina, van Drongelen, Joris, Franssen, Maureen T.M., Sikkema, J. Marko, Duvekot, Hans J.J., Bekker, Mireille N., van der Post, Joris A.M., Naaktgeboren, Christiana, Mol, Ben W.J., Oudijk, Martijn A., MS Verloskunde, Geboortecentrum voorzitterschap, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Child Health, Epi Methoden Team 1, JC onderzoeksprogramma Methodologie, Visser, Laura, de Boer, Marjon A., de Groot, Christianne J.M., Nijman, Tobias A.J., Hemels, Marieke A.C., Bloemenkamp, Kitty W.M., Bosmans, Judith E., Kok, Marjolein, van Laar, Judith O., Sueters, Marieke, Scheepers, Hubertina, van Drongelen, Joris, Franssen, Maureen T.M., Sikkema, J. Marko, Duvekot, Hans J.J., Bekker, Mireille N., van der Post, Joris A.M., Naaktgeboren, Christiana, Mol, Ben W.J., and Oudijk, Martijn A.
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- 2017
144. Fetal monitoring indications for delivery and 2-year outcome in 310 infants with fetal growth restriction delivered before 32 weeks' gestation in the TRUFFLE study
- Author
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MS Verloskunde, UMC Utrecht, Other research (not in main researchprogram), MS Neonatologie, Brain, Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Ferrazzi, E., Fratelli, Nicola, Frusca, T., Ganzevoort, W., Lees, Christoph C., Napolitano, Raffaele, Todros, T., Wolf, H., Hecher, K., Marlow, N., Arabin, B., Brezinka, C., Diemert, A., Duvekot, Johannes J., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Thilaganathan, B., Valcamonico, A., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., van Haastert, I. C., Kingdom, J.C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Marsal, K., Maurer-Fellbaum, Ute, Mensing van Charante, N., Mulder-De Tollenaer, Susanne, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Prefumo, Federico, Preston, Lucy, Raimondi, Francesco, Rattue, H., TRUFFLE group investigators, MS Verloskunde, UMC Utrecht, Other research (not in main researchprogram), MS Neonatologie, Brain, Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Ferrazzi, E., Fratelli, Nicola, Frusca, T., Ganzevoort, W., Lees, Christoph C., Napolitano, Raffaele, Todros, T., Wolf, H., Hecher, K., Marlow, N., Arabin, B., Brezinka, C., Diemert, A., Duvekot, Johannes J., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Thilaganathan, B., Valcamonico, A., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., van Haastert, I. C., Kingdom, J.C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Marsal, K., Maurer-Fellbaum, Ute, Mensing van Charante, N., Mulder-De Tollenaer, Susanne, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Prefumo, Federico, Preston, Lucy, Raimondi, Francesco, Rattue, H., and TRUFFLE group investigators
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- 2017
145. How to monitor pregnancies complicated by fetal growth restriction and delivery before 32 weeks: post-hoc analysis of TRUFFLE study
- Author
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MS Verloskunde, Other research (not in main researchprogram), MS Neonatologie, Brain, Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, on behalf of the TRUFFLE Group, MS Verloskunde, Other research (not in main researchprogram), MS Neonatologie, Brain, Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, and on behalf of the TRUFFLE Group
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- 2017
146. Dutch STRIDER: Data Monitoring Committee Charter
- Author
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Ganzevoort, Wessel, Bloemenkamp, Kitty, von Dadelszen, Peter, de Groot, Christianne, de Laat, Monique, Mol, Ben Willem, Porath, Martina, van der Post, Joris, and van Wassenaer, Aleid
- Subjects
Sildenafil ,intrauterine growth restrictions (IUGR) ,Data Safety Monitoring Board ,fetal growth restriction (FGR) ,DSMB - Abstract
The purpose of this document is to describe the roles and responsibilities of the independent DMC for the Dutch STRIDER, including the timing of meetings, methods of providing information to and from the DMC, frequency and format of meetings, statistical issues and relationships with other committees.
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- 2016
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147. The Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset fetal growth Restriction)
- Author
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Ganzevoort, Wessel, Bloemenkamp, Kitty, von Dadelszen, Peter, de Groot, Christianne, de Laat, Monique, Mol, Ben Willem, Porath, Martina, van der Post, Joris, and van Wassenaer, Aleid
- Subjects
Sildenafil ,intrauterine growth restrictions (IUGR) ,Adverse neonatal outcome ,Phosphodiesterase 5 Inhibitors ,fetal growth restriction (FGR) ,randomised controlled trial (RCT) - Abstract
Severe, early-onset fetal growth restriction (FGR) due to placental insufficiency is associated with a high risk of perinatal morbidity with long-lasting sequelae and mortality.Placental insufficiency is the result of abnormal formation and function of the placenta(placentation) with inadequate remodelling of the maternal spiral (uteroplacental) arteries.There is currently no therapy available with demonstrated effectiveness. Evidence suggestsSildenafil citrate improves uteroplacental blood flow, growth, and meaningful outcomes. An objective of the study is to evaluate the effectiveness of sildenafil (versus placebo) in achieving healthyperinatal survival.
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- 2016
- Full Text
- View/download PDF
148. Long-term micturition problems of asymptomatic postpartum urinary retention: a prospective case–control study
- Author
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Mulder, Femke E. M., primary, Hakvoort, Robert A., additional, de Bruin, Jan-Peter, additional, Janszen, Erica W., additional, van der Post, Joris A. M., additional, and Roovers, Jan-Paul W. R., additional
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- 2017
- Full Text
- View/download PDF
149. Comparison of clean intermittent and transurethral indwelling catheterization for the treatment of overt urinary retention after vaginal delivery: a multicentre randomized controlled clinical trial
- Author
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Mulder, Femke E. M., primary, Hakvoort, Robert A., additional, de Bruin, Jan P., additional, van der Post, Joris A. M., additional, and Roovers, Jan-Paul W. R., additional
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- 2017
- Full Text
- View/download PDF
150. Barriers and Facilitators for the Use of a Medical Mobile App to Prevent Work-Related Risks in Pregnancy: A Qualitative Analysis
- Author
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Velu, Adeline V, primary, van Beukering, Monique DM, additional, Schaafsma, Frederieke G, additional, Frings-Dresen, Monique HW, additional, Mol, Ben WJ, additional, van der Post, Joris AM, additional, and Kok, Marjolein, additional
- Published
- 2017
- Full Text
- View/download PDF
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