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102. Machine learning for sperm selection

Author

You, Jae Bem, McCallum, Christopher, Wang, Yihe, Riordon, Jason, Nosrati, Reza, and Sinton, David

Abstract

Infertility rates and the number of couples seeking fertility care have increased worldwide over the past few decades. Over 2.5 million cycles of assisted reproductive technologies are being performed globally every year, but the success rate has remained at ~33%. Machine learning, an automated method of data analysis based on patterns and inference, is increasingly being deployed within the health-care sector to improve diagnostics and therapeutics. This technique is already aiding embryo selection in some fertility clinics, and has also been applied in research laboratories to improve sperm analysis and selection. Tremendous opportunities exist for machine learning to advance male fertility treatments. The fundamental challenge of sperm selection — selecting the most promising candidate from 108gametes — presents a challenge that is uniquely well-suited to the high-throughput capabilities of machine learning algorithms paired with modern data processing capabilities.

Published
2024
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103. An Improved Privacy-Preserving Consensus Strategy for AC Microgrids Based on Output Mask Approach and Node Decomposition Mechanism

Author

Hu, Jie, Sun, Qiuye, Wang, Rui, and Wang, Yihe

Abstract

The technology of distributed cooperative consensus has been widely used in inverter-based microgrids. However, the traditional information interaction will lead to the problem of data disclosure. Although privacy issues have been widely researched in the tertiary control layer of microgrids, the issues of secondary control layer have not been properly addressed. To fill this gap, taking voltage restoration as the object, the privacy preserving consensus problem for secondary control layer of nDGs islanded microgrids is considered in this paper. Output mask approach, the basic idea of which is to insert a dynamic mask to the transmitted information, is adopted to achieve an accurate consensus rather than a pre-specified convergence accuracy level by differential private method. After that, a newly state decomposition mechanism is proposed, the DG agent is decomposed into two subagents, called $x^{\alpha} _{i}$ and $x^{\beta} _{i}$ . Among the agent pairs $(x^{\alpha} _{i}, x^{\beta} _{i})$ , choose only one subagent of pair $i$ arbitrarily connected to one subagent of its neighbor agent pair. Furthermore, only the communication lines among the agent pairs are masked. Compared with the existing literature, the constraint on the communication topology can be first removed without additional computational burden. Moreover, the consensus and privacy analysis of the controlled system are carried out. In the end, the simulation results verify the effectiveness of the proposed privacy preserving mechanism in the MATLAB/Simulink environment. Note to Practitioners—With the rapid development of information and intelligent technology, the information system and the physical system of MGs have been deeply integrated to get a higher efficiency of energy utilization. However, the traditional information interaction will lead to the problem of data disclosure. Although privacy issues have been widely researched in the tertiary control layer of microgrids, the issues of secondary control layer have not been properly addressed. Motivated by this, an improved privacy-preserving consensus strategy is proposed for secondary voltage control of islanded microgrids based on a newly node decomposition mechanism and the output mask method in this paper. And the theoretical results of this paper can be easily extended to other multi-agent systems.

Published
2024
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107. High-throughput sperm DNA analysis at the single-cell and population levels.

Author

Simchi, Mohammad, Riordon, Jason, Wang, Yihe, McCallum, Christopher, You, Jae Bem, Jarvi, Keith, Nosrati, Reza, and Sinton, David

Subjects
DNA analysis, SPERMATOZOA, DIFFUSION coefficients, MICROSCOPY, SEMEN analysis, FLOW cytometry, MALE infertility, INFERTILITY
Abstract

Clinical semen quality assessment is critical to the treatment of infertility. Sperm DNA integrity testing provides critical information that can steer treatment and influence outcomes and offspring health. Flow cytometry is the gold standard approach to assess DNA integrity, but it is not commonly applied at the clinical level. The sperm chromatin dispersion (SCD) assay provides a simpler and cheaper alternative. However, SCD is low-throughput and non-quantitative – sperm assessment is serial, manual and suffers inter- and intra-observer variations. Here, an automated SCD analysis method is presented that enables quantitative sperm DNA quality assessment at the single-cell and population levels. Levering automated optical microscopy and a chromatin diffusion-based analysis, a sample of thousands of sperm that would otherwise require 5 hours is assessed in under 10 minutes – a clinically viable workflow. The sperm DNA diffusion coefficient (DDNA) measurement correlates (R2 = 0.96) with DNA fragmentation index (DFI) from the cytometry-based sperm chromatin structure assay (SCSA). The automated measurement of population-level sperm DNA fragmentation (% sDF) prevents inter-observer variations and shows a good agreement with the SCSA % DFI (R2 = 0.98). This automated approach standardizes and accelerates SCD-based sperm DNA analysis, enabling the clinical application of sperm DNA integrity assessment. [ABSTRACT FROM AUTHOR]

Published
2023
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109. Facet-controlled bifunctional WO3photocathodes for high-performance photo-assisted Li–O2batteries

Author

Wang, Meng, primary, Chen, Jie, additional, Tian, Zhangliu, additional, Dai, Wenrui, additional, Cui, Baihua, additional, Cui, Xinhang, additional, Wang, Dong, additional, Xiao, Yukun, additional, Lian, Xu, additional, Jiang, Chonglai, additional, Yang, Haotian, additional, Wang, Yihe, additional, Sun, Zejun, additional, Ding, Yishui, additional, Sun, Yi-Yang, additional, Zhang, Jia, additional, and Chen, Wei, additional

Published
2023
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114. Epitaxial Growth of Single-Layer Kagome Nanoflakes with Topological Band Inversion

Author

Duan, Sisheng, primary, You, Jing-Yang, additional, Gou, Jian, additional, Chen, Jie, additional, Huang, Yu Li, additional, Liu, Meizhuang, additional, Sun, Shuo, additional, Wang, Yihe, additional, Yu, Xiaojiang, additional, Wang, Li, additional, Feng, Yuan Ping, additional, Sun, Yi-yang, additional, Wee, Andrew T. S., additional, and Chen, Wei, additional

Published
2022
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121. Protocol of a prospective multicenter randomized controlled trial of robot-assisted stereotactic lesioning in the treatment of focal drug-resistant epilepsy.

Author

Gong, Mingkun, Xu, Ke, Shan, Yongzhi, Wang, Yihe, Zhang, Chao, Wang, Xiongfei, Zhou, Jian, Guan, Yuguang, Li, Tianfu, and Luan, Guoming

Subjects
PARTIAL epilepsy, SURGICAL robots, FOCAL cortical dysplasia, BRAIN stimulation, HIPPOCAMPAL sclerosis, DEEP brain stimulation, CLINICAL trials, RANDOMIZED controlled trials
Abstract

Background: This protocol describes the design of a multicenter randomized controlled trial of robot-assisted stereotactic lesioning versus epileptogenic foci resection. Typical causes of focal epilepsy include hippocampal sclerosis and focal cortical dysplasia. These patients usually present with drug resistance and require surgical treatment. Although epileptogenic foci resection is still the most commonly used treatment for such focal epilepsy, there is increasing evidence that epileptogenic focus resection may lead to neurological impairment. The treatment of epilepsy with a robot-assisted stereotactic lesioning mainly includes two new minimally invasive surgical methods: radiofrequency thermocoagulation (RF-TC) and laser interstitial thermal therapy (LITT). Seizure-free is less likely to be achieved by these two procedures, but neurologic preservation is better. In this study, we aimed to compare the safety and efficacy of RF-TC, LITT, and epileptogenic foci resection for focal drug-resistant epilepsy. Methods: This is a multicenter, three-arm, randomized controlled clinical trial. The study will include patients older than 3 years of age with epilepsy who have had medically refractory seizures for at least 2 years and are eligible for surgical treatment with an epileptogenic focus as determined by multidisciplinary evaluation prior to randomization. The primary outcome measure is seizure outcome (quantified by seizure remission rate) at 3-month, 6-month, and 1-year follow-up after treatment. Postoperative neurologic impairment, spectrum distribution change of video electroencephalogram, quality of life, and medical costs will also be assessed as secondary outcomes. Trial registration: Chinese Clinical Trials Registry ChiCTR2200060974. Registered on June 14, 2022. The status of the trial is recruiting, and the estimated study completion date is December 31, 2024. [ABSTRACT FROM AUTHOR]

Published
2023
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128. High‐Throughput, Living Single‐Cell, Multiple Secreted Biomarker Profiling Using Microfluidic Chip and Machine Learning for Tumor Cell Classification

Author

Wang, Chao, primary, Wang, Chunhua, additional, Wu, Yu, additional, Gao, Jianwei, additional, Han, Yingkuan, additional, Chu, Yujin, additional, Qiang, Le, additional, Qiu, Jiaoyan, additional, Gao, Yakun, additional, Wang, Yanhao, additional, Song, Fangteng, additional, Wang, Yihe, additional, Shao, Xiaowei, additional, Zhang, Yu, additional, and Han, Lin, additional

Published
2022
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130. StarRescue : Transforming A Pong Game to Visually Convey the Concept of Turn-taking to Children with Autism

Author

Huang, Yuxuan, Wang, Yihe, Xiao, Tongxin, Bei, Rongqi, Zhao, Yuhang, Lu, Zhicong, Tong, Xin, Huang, Yuxuan, Wang, Yihe, Xiao, Tongxin, Bei, Rongqi, Zhao, Yuhang, Lu, Zhicong, and Tong, Xin

Abstract

Previous research has shown that children with autism face severe social collaboration challenges such as having issues with turn-taking, which is essential when developing social skills. However, few digital interventions have provided visual support for the development of turn-taking behaviour. To visually manifest the process of turn-taking, this research transformed a pong game into a two-player tablet game, i.e., StarRescue. In this paper, we introduce StarRescue's game design decisions and preliminary findings gathered from semi-structured interviews with teachers and parents of pre-school children with high-functioning autism. The results demonstrated that StarRescue has the potential to help children with autism improve their social behaviors. Furthermore, this research shed light on future tablet game design to enhance turn-based collaboration for children with autism., QC 20230622

Published
2022
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131. Activation and Inhibition of Human Matrix Metalloproteinase-9 (MMP9) by HOCl, Myeloperoxidase and Chloramines

Author

Wang, Yihe, Chuang, Christine Y., Hawkins, Clare L., Davies, Michael J., Wang, Yihe, Chuang, Christine Y., Hawkins, Clare L., and Davies, Michael J.

Abstract

Matrix metalloproteinase-9 (MMP9, gelatinase B) plays a key role in the degradation of extracellular-matrix (ECM) proteins in both normal physiology and multiple pathologies, including those linked with inflammation. MMP9 is excreted as an inactive proform (proMMP9) by multiple cells, and particularly neutrophils. The proenzyme undergoes subsequent processing to active forms, either enzymatically (e.g., via plasmin and stromelysin-1/MMP3), or via the oxidation of a cysteine residue in the prodomain (the "cysteine-switch"). Activated leukocytes, including neutrophils, generate O-2(-) and H2O2 and release myeloperoxidase (MPO), which catalyzes hypochlorous acid (HOCl) formation. Here, we examine the reactivity of HOCl and a range of low-molecular-mass and protein chloramines with the pro- and activated forms of MMP9. HOCl and an enzymatic MPO/H2O2/Cl- system were able to generate active MMP9, as determined by fluorescence-activity assays and gel zymography. The inactivation of active MMP9 also occurred at high HOCl concentrations. Low (nM-low mu M) concentrations of chloramines formed by the reaction of HOCl with amino acids (taurine, lysine, histidine), serum albumin, ECM proteins (laminin and fibronectin) and basement membrane extracts (but not HEPES chloramines) also activate proMMP9. This activation is diminished by the competitive HOCl-reactive species, methionine. These data indicate that HOCl-mediated oxidation and MMP-mediated ECM degradation are synergistic and interdependent. As previous studies have shown that modified ECM proteins can also stimulate the cellular expression of MMP proteins, these processes may contribute to a vicious cycle of increasing ECM degradation during disease development.

Published
2022

132. Multi-Omics Analysis Reveals Changes in the Intestinal Microbiome, Transcriptome, and Methylome in a Rat Model of Chronic Non-bacterial Prostatitis:Indications for the Existence of the Gut-Prostate Axis

Author

Liu, Junsheng, Wang, Yihe, Zhang, Guangwen, Liu, Liu, Peng, Xichun, Liu, Junsheng, Wang, Yihe, Zhang, Guangwen, Liu, Liu, and Peng, Xichun

Abstract

Chronic non-bacterial prostatitis (CNP) is one of the most prevalent diseases in human males worldwide. In 2005, the prostate-gut axis was first proposed to indicate the close relationship between the prostate and the intestine. This study investigated CNP-induced changes of the gut microbiota, gene expression and DNA methylation in a rat model by using multi-omics analysis. Firstly, 16S rDNA sequencing presented an altered structure of the microbiota in cecum of CNP rats. Then, transcriptomic analysis revealed that the expression of 185 genes in intestinal epithelium was significantly changed by CNP. These changes can participate in the immune system, digestive system, metabolic process, etc. Finally, methylC-capture sequencing (MCC-Seq) found 73,232 differentially methylated sites (DMSs) in the DNA of intestinal epithelium between control and CNP rats. A combined analysis of methylomics and transcriptomics suggested an epigenetic mechanism for CNP-induced differential expression genes correlated with intestinal barrier function, immunity, metabolism, enteric infectious disease, etc. More importantly, the transcriptomic, methylomic and gut microbial changes were highly correlated with multiple processes including intestinal immunity, metabolism and epithelial barrier function. In this study, disrupted homeostasis in the gut microbiota, gene expression and DNA methylation were reported in CNP, which supports the existence of the gut-prostate axis.

Published
2022

137. Identification of SARS-CoV-2 Variants Using Viral Sequencing for the Centers for Disease Control and Prevention Genomic U.S. Surveillance Program.

Author

Goswami, Chirayu, primary, Sheldon, Michael, additional, Bixby, Christian, additional, Keddache, Mehdi, additional, Bogdanowicz, Alexander, additional, Wang, Yihe, additional, Schultz, Jonathan, additional, McDevitt, Jessica, additional, LaPorta, James, additional, Kwon, Elaine, additional, Buyske, Steven, additional, Garbolino, Dana, additional, Biloholowski, Glenys, additional, Pastuszak, Alex, additional, Storella, Mary, additional, Bhalla, Amit, additional, Charlier-Rodriguez, Florence, additional, Hager, Russ, additional, Grimwood, Robin, additional, and Nahas, Shareef Amin, additional

Published
2022
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143. Non-Negligible Impact of Tides on the Riverine Flux of Microplastics

Author

Wei, Nian, primary, Bai, Mengyu, additional, Wang, Yihe, additional, Wang, Jinzhao, additional, Liu, Kai, additional, Zhang, Feng, additional, Wang, Xiaohui, additional, Wu, Tianning, additional, Zhang, Zhiwei, additional, Li, Changjun, additional, Zhu, Lixin, additional, Song, Zhangyu, additional, Jiang, Peilin, additional, and Li, Daoji, additional

Published
2022
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