Search

This study explored the role of irisin/fibronectin type III domain-containing protein 5 (FNDC5) in epithelial ovarian cancer and investigated its underlying mechanisms.Immunohistochemistry was performed to analyze the expression of irisin/FNDC5 in epithelial ovarian cancer and normal ovarian tissues. Cell Counting Kit-8, transwell, and wound-healing assays were performed to examine the effect of irisin on the viability, migration, and invasion of ovarian cancer cells, respectively. Western blotting was used to detect the changes of epithelial-mesenchymal transition (EMT)-related proteins and phosphatidylinositol 3-kinase (PI3K)/Akt pathway proteins. Ovarian cancer cells were treated in vitro with the PI3K agonist (740Y-P) in combination with irisin to explore the mechanism of irisin in ovarian cancer.The expression of irisin/FNDC5 in epithelial ovarian cancer tissue was significantly higher than that in normal ovarian tissues, and the expression in late stage patients with lymph node metastasis was lower than that in early stage patients without metastasis. Irisin inhibited the proliferation, invasion, and migration of epithelial ovarian cancer cells, down-regulated phosphorylated Akt, and inhibited EMT progression. The PI3K agonist, 740Y-P, partially reversed the effects of irisin on the invasion, migration, and EMT of ovarian cancer cells.These findings show that irisin/FNDC5 was highly expressed in ovarian cancer tissues, which may regulate the EMT through the PI3K/Akt signaling pathway and inhibit the proliferation, invasion, and migration of epithelial ovarian cancer.

In this study, we aimed to investigate the age-related risk of second breast cancer (SBC) and second gynecological malignant neoplasms (SGMNs) in female differentiated thyroid cancer (DTC) survivors by utilizing the Surveillance, Epidemiology, and End Results (SEER) database.A total number of 55,622 female DTC patients were identified between 1975 and 2016, including 2168 patients who developed SBC and SGMNs. The Fine and Gray model was used to calculate the cumulative incidence and sub-distribution hazards ratios (SHR). Poisson regression analysis was employed to calculate the relative risk (RR) and standardized incidence ratio (SIR). Kaplan-Meier survival and log-rank test analyses were also performed.The overall 40-year cumulative incidence of SBC and SGMNs was 18.9%. Their incidence in the adolescent and young adults (AYA) group increased slowly in the first 30 years, but then was rapidly elevated in the last decade. It increased gradually in the middle-aged adults group and in the first 25 years in the older adults group, but it scarcely increased thereafter. Both the middle-aged adults (adjusted SHR, 2.09; RR, 1.76) and the older adults (adjusted SHR, 1.32; RR, 1.58) groups had higher risks of developing combined SBC and SGMNs than the AYA group. The risks increased mainly in the early latency period. The three groups also had higher SIRs than the US general population. Besides, the best survival after SBC and SGMNs was observed in the AYA group.Age was an independent risk factor for SBC and SGMNs incidences among female DTC survivors.

Maize growth, organ development, and yield formation are highly controlled by the manner in which the plant captures, partition, and remobilizes biomass and phosphorus (P). Better understanding of biomass and P accumulation, partition, and remobilization processes will improve modeling of crop resource use. However, there is still a lack of detailed data to parameterize the modeling of these processes, particularly for modern maize cultivars. A two-year (2016 and 2017) field experiment with three P fertilization treatments (0 (P0), 75 (P75), and 300 (P300) kg P2O5 ha−1) was conducted on a Fluvo-aquic soil (Quzhou, Hebei province, China) to collect data and quantify key processes for a representative modern maize cultivar (Zhengdan 958) widely grown in China. The proportions of biomass and P partitioned into various maize organs were unaffected by P application rate. Zhengdan 958 showed a much lower leaf-senescence rate than older cultivars, resulting in post-silking leaf photosynthesis being sufficient to meet grain biomass demand. In contrast, 50%–85% of leaf P and 15%–50% of stem P accumulated pre-silking were remobilized into grain, in spite of the large proportion of post-silking P uptake. Our results are consistent with the theory that plants use resources according to the priority order of re-allocation from senescence followed by assimilation and uptake, with the re-translocation of reserves last. The results also enabled us to estimate the threshold P concentrations of Zhengdan 958 for modeling crop P demand. The critical leaf P concentration for individual leaves was 0.25%–0.30%, with a corresponding specific leaf P (SLP) of 75–100 mg P m−2. The structural P concentration for leaf was 0.01%, corresponding to an SLP of 3.8 mg P m−2. The maximum P concentrations of leaves and stems were 0.33% and 0.29%. The residual P concentration for stems was 0.006%.

Crisp-like MOF derivatives were fabricated by using MOF particles as precursors via the crystalline transformation process and sulfidation reactions.

Sensitive sensing of nitroaromatic compounds (NACs) is realized by using luminescent lanthanum-tricarboxytriphenylamine (La-TCA) nanosheets fabricated by a top-down sonication assisted strategy. The accessible Lewis base sites and electron-rich fluorophores on the surface of the La-TCA nanosheets enable them to interact with electron-deficient NACs, delivering multi-responsive behaviours (emission intensity quenching, wavelength red-shift and valley) for hydroxyl group NACs.

Enzyme/MOF composites with high activity and stability were synthesized via the pressure-induced-stimulated-aging (PISA) strategy.

The dynamic recrystallization (DRX) behaviors and their transformation process during hot deformation with various Zener–Hollomon (Z) values were investigated in nuclear grade 316H stainless steel, and the factors influencing DRX transformation, especially adiabatic heating, were evaluated in depth. During hot deformation, with the increase of the Z value, the degree of flow softening (DFS) showed a tendency to decrease first and then increase gradually. The analysis of the microstructure revealed that at low Z value (not exceeding 3.9 × 1019 s–1) deformation conditions, DRX was massively activated and the recrystallization mechanism had a transition from continuous DRX (CDRX) to discontinuous DRX (DDRX) with the increasing Z values, leading to the transition of homogeneous grains to heterogeneous grains. Furthermore, with the reactivation of DRX at high Z value deformation conditions, the discontinuous DRX becomes the primary recrystallization mode. Adiabatic heating plays an important role in facilitating the reactivation of DRX and flow softening during hot deformation with low temperature or high strain rate (high Z values, above 6.1 × 1021 s–1).

Fabrication of multifunctional catalysts has always been the pursuit of synthetic chemists due to their efficiency, cost-effectiveness, and environmental friendliness. However, it is difficult to control multi-step reactions in one-pot, especially the spatial compartmentalization of incompatible active sites. Herein, we constructed metal-organic framework (MOF) composites which regulate the location distribution of metal nanoparticles according to the reaction path and coupled with the diffusion of substrates to achieve tandem reaction. The designed UiO-66-Pt-Au catalyst showed good activity and selectivity in hydrosilylation-hydrogenation tandem reaction, because the uniform microporous structures can control the diffusion path of reactants and intermediates, and Pt and Au nanoparticles were arranged in core-shell spatial distribution in UiO-66. By contrast, the low selectivity of catalysts with random deposition and physical mixture demonstrated the significance of artificial control to the spatial compartmentalization of active sites in tandem catalytic reactions, which provides a powerful approach for designing high-performance and multifunctional heterogeneous catalysts.

The continuing increase in the global saline-alkali land area has made saline-alkali stress the principal abiotic stress limiting plant growth. Potato is the most important non-grain crop, and its production is also severely limited by saline-alkali stress. However, few studies have addressed the mechanism of saline-alkali tolerance of potato with a focus on its response to neutral salt NaCl stress, or its response to alkali stress. Recently, miRNA-mRNA analyses have helped advance our understanding of how plants respond to stress. Here, we have characterized the morphological, physiological, and transcriptome changes of tissue culture seedlings of potato variety "Qingshu No. 9" treated with NaHCO3 (for 0, 2, 6, and 24 h). We found that the leaves of tissue culture seedlings wilted and withered under alkali stress, and the contents of ABA, BRs, trehalose, and lignin in roots increased significantly. The contents of GAs decreased significantly. Subsequently, miRNA-seq analysis results identified 168 differentially expressed miRNAs (DEMIs) under alkali stress, including 21 exist miRNAs and 37 known miRNAs from 47 families and 110 novel miRNAs. The mRNA-seq results identified 5731 differentially expressed mRNAs (DEMs) under alkali stress. By miRNA-mRNA integrated analysis, were obtained 33 miRNA-target gene pairs composed of 20 DEMIs and 33 DEMs. Next, we identified the "phenylpropanoid biosynthesis", "plant hormone signal transduction", and "starch and sucrose metabolism" pathways as necessary for potato to respond to alkali stress. miR4243-x and novel-m064-5p were involved in the response of potato to alkali stress by their negative regulatory effects on shikimate O-hydroxycinnamoyltransferase (HCT) and sucrose-phosphate synthase (SPS) genes, respectively. The expression results of miRNA and mRNA were verified by quantitative real-time PCR (qRT-PCR). Our results clarify the mechanism of potato response to alkali stress at the miRNA level, providing new insights into the molecular mechanisms of potato's response to alkali stress. We report many candidate miRNAs and mRNAs for molecular-assisted screening and salt-alkali resistance breeding.

Mineral particles are ubiquitous in the atmosphere and exhibit an important effect on the photooxidation of volatile organic compounds (VOCs). However, the role of mineral particles in the photochemical oxidation mechanism of VOCs remains unclear. Hence, the photooxidation reactions of acrolein (ARL) with OH radical (OH) in the presence and absence of SiO2 were investigated by theoretical approach. The gas-phase reaction without SiO2 has two distinct pathways (H-abstraction and OH-addition pathways), and carbonyl-H-abstraction is the dominant pathway. In the presence of SiO2, the reaction mechanism is changed, i.e., the dominant pathway from carbonyl-H-abstraction to OH-addition to carbonyl C-atom. The energy barrier of OH-addition to carbonyl C-atom deceases 21.33 kcal/mol when SiO2 is added. Carbonyl H-atom of ARL is occupied by SiO2 via hydrogen bond, and carbonyl C-atom is activated by SiO2. Hence, the main product changes from H-abstraction product to OH-adduct in the presence of SiO2. The OH-adduct exhibits a thermodynamic feasibility to yield HO2 radical and carboxylic acid via the subsequent reactions with O2, with implications for O3 formation and surface acidity of mineral particles.

Metal nanowires are promising building blocks for optoelectronic nanodevices, so their independent and precise manipulation is urgently needed. However, the direct optical manipulation methods are severely hampered due to the high absorption and scattering characteristics of the metal nanowires. Here, a microsphere-assisted indirect optical manipulation method is proposed, and precise manipulation of a single Ag nanowire is demonstrated in liquid. The microsphere is actuated to rotate to generate a microvortex by dynamic optical traps. Under the action of shear stress, the Ag nanowire within the microvortex can be controllably rotated and accurately orientated. By manipulating the position of the microsphere using a single optical trap, a precise positioning of the nanowire can be achieved under the action of pushing force. On this basis, the Ag nanowire-based structures were assembled. This indirect optical manipulation avoids the direct interaction between the light and the nanowires, which makes it independent of both the laser (power, wavelength) and the nanowire (material, size, and shape). Hence, the microsphere-assisted manipulation method is simple and general for independent and precise manipulation of a single nanowire, which is of great significance to the fabrication of optoelectronic nanodevices.

High-loading Pt/C catalysts play an important role in the practical application of metal-air batteries and fuel cells because of their superior activity, high conductivity, and commercial availability. It is well known that high loadings always lead to the agglomeration of Pt nanoparticles, resulting in a loss of catalytic activity and stability; thus, it still remains a challenge to prepare high-loading Pt/C catalysts with high dispersion and small particle sizes. Here, we introduce a surfactant-assisted microwave discharge method to prepare high-loading (40 wt %) Pt/C electrocatalysts with ultrafine particle sizes (∼3.19 nm) and good dispersion. Benefitting from the high-temperature property and reducibility of carbon-induced-arc, the surfactant and Pt precursors undergo rapid decomposition, reduction, and carbonization, generating the structure of Pt@C on carbon black. The carbon derived from the surfactant can not only inhibit the agglomeration of Pt nanoparticles but also prevent the Pt core from toxication, ensuring high activity and stability of the high-loading Pt/C catalyst. When evaluated in the oxygen reduction reaction, the as-prepared Pt/C catalyst demonstrates a comparable activity and better methanol resistance to commercial Pt/C.

Magnetic field enhanced electrocatalysis has recently emerged as a promising strategy for the development of a viable and sustainable hydrogen economy via water oxidation. Generally, the effects of magnetic field enhanced electrocatalysis are complex including magnetothermal, magnetohydrodynamic and spin selectivity effects. However, the exploration of magnetic field effect on the structure regulation of electrocatalyst is still unclear whereas is also essential for underpinning the mechanism of magnetic enhancement on the electrocatalytic oxygen evolution reaction (OER) process. Here, it is identified that in a mixed NiFe

Nanowire-based optical biosensors with high sensitivity are highly desired for the detection of biological microenvironments and analysis of cellular processes. However, the current nanowire biosensors are mostly fabricated with metal and semiconductor materials, which are not suitable for long-term use in biological environments due to their incompatible and nondegradable properties. Biosensors based on biofriendly materials (e.g., spider silk) often do not have high enough sensitivity due to high losses or micron sizes. Here, polylactic acid (PLA), a polymer with high optical transparency, good biocompatibility, biodegradability, and flexibility, is used to fabricate nanowires using a directly drawing method for the first time. Because of the strong evanescent wave and abundant carboxyl groups on the surface of nanowires, an ultralow concentration sensing of cytochrome c is achieved with a limit of detection of 1.38 × 10-17 M, which is much lower than other detection results using semiconductor/metal-based nanosensors (10-6 to 10-12 M). On this basis, a label-free and real-time monitoring of cell apoptosis is realized. In addition, by doping quantum dots, the functionalized PLA nanowires can also sense a change in pH. These results are suggestive of the potential for PLA nanowires applied in multifunctional biosensing and biodetection, pushing forward the photomedicine field.

For the first time, we developed porous Pt-Ni alloying nanoparticles with predominant (111) facets under intense magnetic fields. Electrochemical analysis revealed that the Pt-Ni alloying nanoparticles obtained at 2 Tesla exhibited a superior catalytic activity and durability for oxygen reduction reaction. This work demonstrated that the imposition of intense magnetic field could be considered as a new approach for developing efficient alloying electrocatalysts with preferential facets.

Optical manipulation of metal nanowires offers a promising route to building optoelectronic nanosystems, which remains a challenge because of their strong absorption or scattering properties. Here, precise optical manipulation of a single Ag nanowire, including capture, translation, rotation, immobilization, and release, was readily achieved within a large operation range of 100 μm by a single unpolarized Gaussian beam based on an optical scattering force. Besides, the optical forces and torques exerted on the Ag nanowires under different conditions were quantitatively analyzed and calculated by simulation to give insight into the manipulation mechanism. This proposed scattering-force-based optical manipulation method also has great position and orientation stability with a capture stiffness of 1.2 pN/μm and an orientation standard deviation of 0.3°. More surprisingly, it is independent of both laser polarization and the metal material, shape, and size and is a universal and promising strategy for the manipulation and assembly of nontransparent structures in mesoscopic/Mie sizes.

In this paper, a top-down method is used to partially hydrolyze leather to achieve a leather-based gel electrolyte, and successfully develop a leather-based all-in-one configured flexible supercapacitor. The hierarchical structure of collagen fibers effectively solves the interface problem of flexible supercapacitors, and at the same time endows the gel electrolyte with degradability and reproducibility.

The prognosis of patients with T-cell acute lymphoblastic leukemia (T-ALL) has been largely lacked behind than that of patients with B-cell ALL, especially in refractory or relapsed cases. Here, we describe a 4.7-year-old male child with TCF-SPI1-postitve T-ALL who developed refractoriness disease after a seven drugs-conventional therapy. Several studies have suggested the therapeutic potential of dasatinib in refractory T-ALL. Actually, dasatinib-included therapy dramatically reduces the leukemic burden and re-induces this patient into complete remission without systemic adverse events. Although this is a single exceptional case, the translational potential evidence of dasatinib in specific T-ALL subtype should not be under-estimated.

Microreactor technology has attracted tremendous interest due to its features of a large specific surface area, low consumption of reagents and energy, and flexible control of the reaction process. As most of the current microreactors have volumes of microliters or even larger, effective methods to reduce the microreactors' sizes and improve their flexibility and controllability have become highly demanded. Here we propose an optical method of coalescence and splitting of femto-/pico-liter droplets for application in microreactors. Firstly, two different schemes are adopted to stably trap and directionally transport the microdroplets (oil and water) by a scanning optical tweezing system. Then, optically controlled coalescence and splitting of the microdroplets are achieved on this basis, and the mechanism and conditions are explored. Finally, the microdroplets are used as microreactors to conduct the microreactions. Such microreactors combine the advantages of miniaturization and the multi-functions of microdroplets, as well as the precision, flexibility, and non-invasiveness of optical tweezers, holding great potential for applications in materials synthesis and biosensing.

The effect of sulfuric acid (SA) concentrations on heterogeneous reactions of amines such as methylamine (MA), dimethylamine (DMA), and trimethylamine (TMA) at the air-particle interface is investigated using combined classical molecular dynamics, Born-Oppenheimer molecular dynamics, and quantum chemical calculations. The results show that the mixtures of these amine vapors can accumulate at the air-particle interface and then participate in two types of heterogeneous reactions depending on the SA concentrations in the aqueous particles. At high SA concentrations, amines are neutralized by H3O+ and form ammonium salts within only a few picoseconds. At low SA concentrations, amines mainly proceed by hydrolysis reactions and produce ionic pairs of ammonium and OH-. However, the formed ionic pair is extremely unstable, and the reverse reaction takes place. Considering that the salt conversion time scales of amines at high SA concentrations are 2.5-15 times faster than those at low SA concentration, amine accumulation at high acidity particles is more favored.

To estimate the value of gynecologic imaging reporting and data system (GI-RADS) combined with 3-dimensional contrast-enhanced ultrasound (3D-CEUS) scoring system in the differential diagnosis of ovarian tumor. Both of 2-dimensional ultrasound (2D-US) and 3D-CEUS were performed on 114 patients with ovarian masses by Voluson E8 with SonoVue (Bracco, Italy). Besides, dynamic contrast-enhanced-magnetic resonance imaging (DCE-MRI) (Siemens Magneton Verio 3.0T, Germany) was performed on the patients. There were totally 62 benign and 52 malignant ovarian tumors in all patients. The ability of GI-RADS combined with 3D-CEUS scoring system to distinguish benign and malignant ovarian tumors was superior to conventional ultrasound GI-RADS classification. The sensitivity, specificity, and accuracy of GI-RADS combined with 3D-CEUS scoring system were 96.2% and 98.1%, 87.10%, whereas those of MRI were 87.10%, 91.23%, and 92.11% respectively, indicating that there was high concordance in ovarian tumors assessment between the 2 diagnostic methods. The new scoring system has a good correlation with microvessel density (P = 0.000, r = 0.73), estrogen receptor (P = 0.000, r = 0.59), progesterone receptor (P = 0.000, r = 0.56), and matrix metalloproteinase-9 (P = 0.000, r = 0.61). The GI-RADS combined with 3D-CEUS scoring system was valuable in clinical diagnosis and differential diagnosis of ovarian tumor and show good agreement with MRI.

The metal nodes, functionalized ligands, and uniform channels of metal-organic frameworks (MOFs) are typically utilized to regulate the catalytic properties of metal nanoparticles (MNPs). However, though the ligand functionalization could impact the properties of the metal nodes and channels, which might further regulate the catalytic activity and selectivity of MNPs, related research in the design of MNP/MOF catalysts was usually neglected. Herein, we synthesized a series of Pt@UiO-66 composites (Pt@UiO-66-NH2, Pt@UiO-66-SO3H, and Pt@UiO-66) with slightly different organic ligands, which enhanced steric hindrance and contributed to multipathway electron transfer in selective hydrogenation of linear citronellal. The selectivity toward citronellol was gradually improved along with the increased size of functional groups (hydrogen, amino groups, and sulfo groups) on organic ligands, which enhanced steric hindrance provided by channels. In addition, the X-ray photoelectron spectroscopy measurements also revealed that the electronic state of Pt NPs was regulated through multipathway electron transfer from Pt NPs to metal nodes, between organic ligands and Pt NPs/metal nodes. Our research proved that the ligand functionalization altered physiochemical properties of the channels and metal nodes, further together managing the catalytic performance of Pt NPs through enhanced steric hindrance and multi-pathway electron transfer.

Shape-selective catalysis plays a key role in chemical synthesis. Porous nanomaterials with uniform pore structures are ideal supports for metal nanoparticles (MNPs) to generate efficient shape-selective catalysis. However, many commercial irregular porous nanomaterials face the challenge to realize satisfactory shape selectivity due to the lack of molecular sieving structures. Herein, we report a concept of creating shape selectivity in MNPs/porous nanomaterials through intentionally poisoning certain MNPs using suitable modifiers. The remaining MNPs within the substrates can cooperate with the channels to generate selectivity. Such a strategy not only applies to regular porous nanomaterials (such as MOFs, zeolites) but also extended to irregular porous nanomaterials (such as active carbon, P25). Potentially, the matching among different MNPs, corresponding modifiers, and porous nanomaterials makes our strategy promising in selective catalytic systems.

The interaction and orientation of hypochlorous acid (HOCl) on the ice surface has been of great interest as it has important implications to ozone depletion. As HOCl interacts with the ice surface, previous classical molecular dynamics simulations suggest its OH moiety orients to the outside of the ice surface, whereas the quantum calculations performed at 0 K indicate its Cl atom is exposed. To resolve this contradiction, herein, Born-Oppenheimer molecular dynamics simulations are adopted, and the results suggest that at ambient temperature, the interaction between HOCl with interfacial water is dominated by the robust H-bond of (HOCl)H-O(H2O). As a result, the HOCl mainly acts as the proton donor to the water surface, which thus can participate in proton transfer reactions via the promotion of interfacial water. Moreover, the Cl atom of HOCl is found to be exposed to the outside of the water surface. Therefore, during the heterogeneous reactions of HOCl on the water surface, the Cl atom becomes the reactive site and is easily attacked by other species.

Metal-organic framework (MOF) nanosheets and covalent organic framework (COF) nanosheets as emerging porous materials nanosheets have captured increasing attention owing to their attractive properties originating from the advantages of large lateral size, ultrathin thickness, tailorable physiochemical environment, flexibility and highly accessible active sites on surface, and the applications of them have been explored in a wide range of fields. Although MOF and COF nanosheets own many similar properties, their applications in various fields show significant differences, probably due to their different compositions and bonding modes. Hence, we summarize the recent progress of MOF and COF nanosheets by comparative analysis on their advantages and limitations in synthesis and applications, providing a more profound and full-scale perspective for researchers or beginners to understand this field. Herein, the categories of preparation methods of MOF and COF nanosheets are firstly discussed, including top-down and bottom-up methods. Secondly, the applications of MOF and COF nanosheets for separation, catalysis, sensing and energy storage are summarized. Finally, based on current achievements, we put forward our personal insights into the challenges and outlooks on the synthesis, characterizations, and promising applications for future research of MOF and COF nanosheets.

The exploration of catalysts with large surface areas is an efficacious strategy in oxygen reduction reaction (ORR) catalyst design. In this work, two-dimensional porous PtPd nanostructures were sy...

Lithium-sulfur battery (Li–S) is considered as one of the new-generation rechargeable batteries with high performance because of its extremely high theoretical capacity, energy density, environmental harmony and low cost. However, low electrical and ionic conductivity of sulfur, safety concerns and parasitic reaction generated by the dissolved polysulfide species in electrolyte hinder the commercialization of Li–S battery. Herein, we report a polyhedral porous structure comprising of carbon coating metal selenide nanoparticles (CoSe2/C), which could not only host sulfur for Li-S battery owing to its porous and conductive structure, but also mitigate the shuttle phenomenon by polysulfides adsorption and catalytic acceleration of redox kinetics. As a result, a performance enhanced CoSe2/C-S electrode for Li-S battery is achieved.

Precision medicine has become a trend in the field of biomedical research. Analysis of mRNA and microRNA (miRNA) is a basis of it. Although the analyses of mRNA and miRNA in different cancers have been studied widely, only a few integrated studies concerning their interactions on large patient cohorts have been done. In this article, we study the integrated significance of mRNA, miRNA, and their interactions in the survival analysis of breast cancer (BRCA). We detect differential expression genes, then we analyze significant genes of BRCA by the Cox model. The model described in this article has better performance than the model without predictors of interactions of miRNA and mRNA. The average C index considering miRNA-target interactions is 0.7, which achieves 84% improvement compared with the model without interactions, which is 0.38.

The ability of perceiving external pressures and conducting corresponding signals is one of the important functions of flexible electronics, which has been widely studied in electronic skin, prosthetics, robotics, healthcare, human-machine interfaces, etc. Pressure sensor should not be limited to the detection of unidirectional pressure. Here, a leather-based electronic pressure sensor and corresponding arrays with bidirectional sensing capability are demonstrated. The sensor/arrays consisting of two pieces of stacked leather both modified with acidified carbon nanotubes (a-CNTs) can achieve multi-level response to pressure over a broad working range and sense pulling force opposite to pressure. With polyurethane mixed with ferriferrous oxide (Fe3O4) powder being applied to their upper surface, the resistive sensor/individual units of arrays can also detect the magnetic field because of the contactless pulling force generated by the magnetized Fe3O4. Being able to sense pressure, pulling force and magnetic field, the leather-based electronic bidirectional pressure sensor and corresponding arrays with good performance not only exhibit potential for mass production and their broad application prospects, but also provide a new insight for the development of flexible electronics.