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101. Vasculitis

Author

Goronzy, Jörg J., Weyand, Cornelia M., Jameson, J. Larry, editor, and Tsokos, George C., editor

Published
2000
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102. Mitochondria as disease-relevant organelles in rheumatoid arthritis.

Author

Weyand, Cornelia M, Wu, Bowen, Huang, Tao, Hu, Zhaolan, and Goronzy, Jörg J

Subjects
*AUTOIMMUNE diseases, *ORGANELLES, *MITOCHONDRIA, *RHEUMATOID arthritis, *JOINT pain, *T cells, *TISSUE remodeling
Abstract

Mitochondria are the controllers of cell metabolism and are recognized as decision makers in cell death pathways, organizers of cytoplasmic signaling networks, managers of cellular stress responses, and regulators of nuclear gene expression. Cells of the immune system are particularly dependent on mitochondrial resources, as they must swiftly respond to danger signals with activation, trafficking, migration, and generation of daughter cells. Analogously, faulty immune responses that lead to autoimmunity and tissue inflammation rely on mitochondria to supply energy, cell building blocks and metabolic intermediates. Emerging data endorse the concept that mitochondrial fitness, and the lack of it, is of particular relevance in the autoimmune disease rheumatoid arthritis (RA) where deviations of bioenergetic and biosynthetic flux affect T cells during early and late stages of disease. During early stages of RA, mitochondrial deficiency allows naïve RA T cells to lose self-tolerance, biasing fundamental choices of the immune system toward immune-mediated tissue damage and away from host protection. During late stages of RA, mitochondrial abnormalities shape the response patterns of RA effector T cells engaged in the inflammatory lesions, enabling chronicity of tissue damage and tissue remodeling. In the inflamed joint, autoreactive T cells partner with metabolically reprogrammed tissue macrophages that specialize in antigen-presentation and survive by adapting to the glucose-deplete tissue microenvironment. Here, we summarize recent data on dysfunctional mitochondria and mitochondria-derived signals relevant in the RA disease process that offer novel opportunities to deter autoimmune tissue inflammation by metabolic interference. [ABSTRACT FROM AUTHOR]

Published
2023
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109. Regulatory T Cells in Autoimmune Vasculitis

Author

Jin, Ke, primary, Parreau, Simon, additional, Warrington, Kenneth J., additional, Koster, Matthew J., additional, Berry, Gerald J., additional, Goronzy, Jörg J., additional, and Weyand, Cornelia M., additional

Published
2022
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112. Large-vessel vasculitis

Author

Pugh, Dan, primary, Karabayas, Maira, additional, Basu, Neil, additional, Cid, Maria C., additional, Goel, Ruchika, additional, Goodyear, Carl S., additional, Grayson, Peter C., additional, McAdoo, Stephen P., additional, Mason, Justin C., additional, Owen, Catherine, additional, Weyand, Cornelia M., additional, Youngstein, Taryn, additional, and Dhaun, Neeraj, additional

Published
2022
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114. List of contributors

Author

Abell, Thomas, Acosta, Camilo J., Adadey, Samuel Mawuli, Anaya, Juan-Manuel, Annibale, Bruno, Antonini, Simone, Aqeel, Faten, Arepalli, Sruthi, Assassi, Shervin, Babushok, Daria V., Barkin, Jodie A., Bartalena, Luigi, Ben Nasr, Moufida, Berentsen, Sigbjørn, Betterle, Corrado, Birtolo, Maria Francesca, Bisarya, Pooja Nikki, Blüml, Stephan, Bonomi, Marco, Bowlus, Christopher L., Brassard, Alain, Brusch, Anna, Burrone, Marco, Carrillo-Bayona, Jorge Alberto, Casciola-Rosen, Livia, Caturegli, Patrizio, Chang, Christopher, Chatzis, Loukas, Chaves, Juan José, Chen, Dhruti P., Chen, Jingjing, Chen, Saijuan, Cheng, Wenyan, Chhabra, Garvit, Choi, Jamie H., Cianferotti, Luisella, Crowell, Eric, Cuda, Carla M., Davidson, Anne, Deane, Sean, del Carmen Moleon, Maria, Di Dalmazi, Giulia, Dilaghi, Emanuele, Dixon Johns, James, Doost, Mohammad Saffari, Dyke, Jason, D’Addio, Francesca, D’Cruz, David P., Falk, Ronald J., Farina, Antonio, Fattizzo, Bruno, Fernandez-Carbonell, Cristina, Fiorina, Paolo, Flanagan, Eoin P., Franzen, Daniel P., Frederiksen, Henrik, Free, Meghan E., Frejo, Lidia, Fung, Maxwell A., Gaffney, Patrick M., Galindo, Javier Leonardo, Gallo, Daniela, Gately, Ursula, Geetha, Duvuru, Gershwin, M. Eric, Goldbach-Mansky, Raphaela, Goronzy, Jörg J., Goules, Andreas V., Gudjonsson, Johann E., Guilherme, Luiza, Guo, Weinan, Hajj-Ali, Rula A., Hamburger, Nicole, He, Liting, Herrán, María, Hoa, Michael, Honnorat, Jérôme, Hu, Qingjie, Hu, Yue, Husebye, Eystein S., Ippolito, Silvia, James, Eddie A., James, Judith A., Jennette, J. Charles, Jian, Zhe, Jiang, Ying, Kaklamanos, Aimilios, Kalil, Jorge, Kaminski, Henry J., Kammeyer, Ryan, Kaya, Ziya, Kelly, Jennifer A., Khakoo, Nidah Shabbir, Khoury, Samia J., Kolios, Antonios G.A., Königs, Christoph, Kopplin, Laura J., Krupp, Lauren B., Kuker, Russ, Kwapnoski, Zachary, Kyttaris, Vasileios C., La Cava, Antonio, Lahner, Edith, Lania, Andrea G., Lehmann, Helmar C., Levy, Cynthia, Li, Chunying, Li, Kun, Li, Shuli, Li, Xiangqian, Liu, Hui, Liu, Ling, Liu, Yudong, Lleo, Ana, Long, Hai, Lopez-Escamez, Jose A., Lu, Qianjin, Lunati, Maria Elena, Lunn, Michael P.T., Lupi, Isabella, Malattia, Clara, Maletic-Savatic, Mirjana, Marietta, Eric V., Martin, Cole, Martini, Alberto, Mastaglia, Frank, Mathur, Prateek, Mazziotti, Gherardo, McDonald, Benjamin, Mehta, Neesurg S., Mieli-Vergani, Giorgina, Milano, Reza V., Morel, Laurence, Moss, Brandon, Moussa, Kareem, Murray, Joseph A., Naing, LeYu, Needham, Merrilee, Nelson, Andrew J., Nilsson, Jakob, O'Neill, Kimberly A., Ochoa, Jorge R., Öztosun, Gülşen, Pan, Meng, Paramalingam, Shereen, Pathak, Shresh, Pei, Chenchen, Perl, Andras, Perlman, Harris, Persani, Luca, Pillai, Shiv, Piquet, Amanda L., Poddubnyy, Denis, Polo, Fernando, Presotto, Fabio, Rabb, Hamid, Radin, Massimo, Rochat, Pete, Rodolfi, Stefano, Rojas, Manuel, Rosen, Antony, Rossetti, Raffaella, Rubin, David T., Saab, Georges, Sabbadin, Chiara, Salbach, Christian, Schreiber, Karen, Sciascia, Savino, Sheikh, Kazim A., Shen, Yang, Shusko, Alexander R., Sieper, Joachim, Smilek, Dawn Elaine, Smith, Kenneth, Smolen, Josef S., Sorkhabi, Sharareh Yousefpour, Stocker, Abigail, Stone, John H., Stroikova, Vera, Sun, Yonghu, Syrbe, Uta, Tanda, Maria Laura, Taubenslag, Kenneth J., Terziroli Beretta-Piccoli, Benedetta, Tessneer, Kandice L., Thakolwiboon, Smathorn, Tian, Jingru, Tiniakou, Eleni, Titulaer, Maarten J., Tsui, Edmund, Tzioufas, Athanasios G., Vambutas, Andrea, van Steenhoven, Robin W., Varga, John, Vergani, Diego, Villagrán-García, Macarena, Vondenberg, Jaime A., Vora, Paras, Wagner, Catriona A., Wang, Gang, Wang, Jingying, Wang, Min, Wang, Xin, Weinstein, Jessica E., Weyand, Cornelia M., Xin, Yue, Xing, Enze, Yao, Xu, Yu, Cong, Zhang, Furen, Zhang, Jianzhong, Zhang, Xuan, Zhou, Cheng, Zhu, Haiqin, Zhu, Hong, Zinger, Adar, and Zuo, Xiaoxia

Published
2024
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115. Contributors

Author

Abdellatif, Engy, primary, Abeles, Aryeh M., additional, Abelson, Abby G., additional, Abhishek, Abhishek, additional, Abramson, Steven B., additional, Adachi, Jonathan D., additional, Adams, Michael A., additional, Aigner, Thomas, additional, Akira, Shizuo, additional, Aletaha, Daniel, additional, Aliprantis, Antonios O., additional, Almeida de Jesus, Adriana, additional, Altman, Roy D., additional, Amigo, Mary-Carmen, additional, Aringer, Martin, additional, Ascherman, Dana P., additional, Assassi, Shervin, additional, Atamas, Sergei P., additional, Azevedo, Pedro Ming, additional, Baer, Alan N., additional, Baeten, Dominique, additional, Baines, Colin, additional, Baker, Nancy A., additional, Balogh, Emese, additional, Balsa, Alejandro, additional, Baraliakos, Xenofon, additional, Bardin, Thomas, additional, Barnsley, Les, additional, Bathon, Joan M., additional, Bauch, Angela, additional, Belch, Jill J.F., additional, Bellamy, Nicholas, additional, Bellido, Teresita, additional, Benjamin, Michael, additional, Beresford, Michael W., additional, Berman, Brian, additional, Bermas, Bonnie Lee, additional, Bertsias, George, additional, Bilezikian, John P., additional, Bilginer, Yelda, additional, Birnbaum, Julius, additional, Bishop, Felicity L., additional, Bleasel, Jane F., additional, Böhm, Markus, additional, Bolster, Marcy B., additional, Bombardieri, Stefano, additional, Bonelli, Michael, additional, Bonnick, Sydney L., additional, Boumpas, Dimitrios T., additional, Bozec, Aline, additional, Brasington, Richard D., additional, Braun, Juergen, additional, Brown, Matthew A., additional, Bruce, Ian N., additional, Bugbee, William D., additional, Bukhari, Marwan A.S., additional, Burgos-Vargas, Rubén, additional, Burmester, Gerd-Rüdiger, additional, Burns, Jane C., additional, Burr, David B., additional, Buttgereit, Frank, additional, Bykerk, Vivian P., additional, Calabrese, Leonard H., additional, Callen, Jeffrey P., additional, Cavallo, Sabrina, additional, Cawston, Tim E., additional, Chandran, Vinod, additional, Chard, Michael Denis, additional, Chaudhary, Prateek, additional, Chen, Lan X., additional, Choi, Hyon K., additional, Choy, Ernest H., additional, Christopher-Stine, Lisa, additional, Chu, Alvina D., additional, Clauw, Daniel J., additional, Clements, Philip J., additional, Clowse, Megan E.B., additional, Coghlan, J. Gerry, additional, Conaghan, Philip G., additional, Cooper, Cyrus, additional, Costenbader, Karen H., additional, Creamer, Paul, additional, Crispín, José C., additional, Cronstein, Bruce N., additional, Cross, Raymond, additional, Cusano, Natalie E., additional, Cutolo, Maurizio, additional, D'Adamo, Chris, additional, D'Agati, Vivette, additional, D'Cruz, David P., additional, Dagfinrud, Hanne, additional, Daikh, David I., additional, Dalbeth, Nicola, additional, Dalton, Seamus E., additional, Dass, Shouvik, additional, Davis, Aileen M., additional, De Ceulaer, Karel, additional, Deal, Chad L., additional, Deane, Kevin D., additional, Della Rossa, Alessandra, additional, Dellaripa, Paul F., additional, Dennison, Elaine, additional, Denton, Christopher P., additional, Dieppe, Paul, additional, Doherty, Michael, additional, Dolan, Patricia, additional, Donn, Rachelle, additional, Dvorkina, Olga, additional, Dyer, George S.M., additional, Eastell, Richard, additional, Edwards, N. Lawrence, additional, Emery, Paul, additional, Erturan, Gurhan, additional, Espinoza, Luis R., additional, Eyre, Steve, additional, Fanouriakis, Antonios C., additional, Farber, Joshua, additional, Farrokhi, Shawn, additional, Fasth, Anders, additional, Feist, Eugen, additional, Feldman, Debbie, additional, Felson, David T., additional, Fisk, John D., additional, Fitzgerald, G. Kelley, additional, Flores, Raymond H., additional, Fox, David A., additional, Francomano, Clair A., additional, Frangos, Jennifer, additional, Freemont, Anthony J., additional, Fricka, Kevin B., additional, Furst, Daniel E., additional, Gabay, Cem, additional, Gadina, Massimo, additional, Gaston, J.S. Hill, additional, Gay, Steffen, additional, Gensler, Lianne S., additional, Geraldino-Pardilla, Laura, additional, Gerlag, Danielle M., additional, Ginzler, Ellen M., additional, Gizinski, Alison M., additional, Gladman, Dafna D., additional, Gold, Garry E., additional, Goldbach-Mansky, Raphaela, additional, Goldingay, Sarah, additional, Gordon, Sharon M., additional, Gorodkin, Rachel, additional, Goronzy, Jörg J., additional, Görtz, Simon, additional, Grahame, Rodney, additional, Grainger, Andrew J., additional, Gravallese, Ellen M., additional, Greenberg, Jeffrey D., additional, Gujar, Bansari, additional, Hagan, Matilda, additional, Hagley, Karlene, additional, Hakim, Alan J., additional, Hall, John C., additional, Hamuryudan, Vedat, additional, Hanly, John G., additional, Hanson, Eric P., additional, Haraoui, Boulos, additional, Harley, John B., additional, Hashkes, Philip J., additional, Hawker, Gillian A., additional, Hawkins, Philip N., additional, Heiberg, Turid, additional, Heinegård, Dick, additional, Helfgott, Simon M., additional, Ho, Pauline Y.P., additional, Hochberg, Marc C., additional, Hochman, Jacqueline, additional, Hodgkiss-Harlow, Chelsea J., additional, Hoffman, Robert W., additional, Hoffmann, Markus, additional, Holers, V. Michael, additional, Holick, Michael F., additional, Holroyd, Christopher, additional, Hübscher, Osvaldo, additional, Hunter, David J., additional, Husni, M. Elaine, additional, Inman, Robert D., additional, Isaac, Zacharia, additional, Iversen, Maura D., additional, Jabs, Douglas A., additional, Jackson, William, additional, Jaimungal, Sarada, additional, James, Judith A., additional, Javier, Rose-Marie, additional, Johnsen, Alyssa K., additional, Jordan, Joanne M., additional, Kaisho, Tsuneyasu, additional, Kallenberg, Cees G.M., additional, Kane, David, additional, Kapoor, Mohit, additional, Karlson, Elizabeth W., additional, Kassimos, Dimitrios G., additional, Kastner, Daniel L., additional, Katz, Jeffrey N., additional, Kay, Jonathan, additional, Kelly, Jennifer A., additional, Keystone, Edward, additional, Khamashta, Munther A., additional, Khanna, Dinesh, additional, Kjeken, Ingvild, additional, Koch, Alisa E., additional, Koff, Matthew F., additional, Kottyan, Leah, additional, Koutsogeorgopoulou, Loukia A., additional, Kraus, Virginia Byers, additional, Kumar, Pradeep, additional, Kvien, Tore K., additional, Lafyatis, Robert, additional, Landewé, Robert B.M., additional, Langford, Carol A., additional, Lau, Arthur N., additional, Laxer, Ronald M., additional, Learch, Thomas J., additional, Lewith, George, additional, Li, Yi, additional, Liao, Katherine P., additional, Littlejohn, Geoffrey, additional, Lorenzo, Pilar, additional, Luger, Thomas A., additional, Lundberg, Ingrid E., additional, Lundberg, Karin, additional, Machold, Klaus P., additional, MacKenzie, C. Ronald, additional, Mahr, Alfred D., additional, Manheimer, Eric, additional, Marini, Joan C., additional, Marquez, Javier, additional, Marsden, Debbie, additional, Martel-Pelletier, Johanne, additional, Martín-Mola, Emilio, additional, Martínez-Lavín, Manuel, additional, Massarotti, Elena M., additional, Matteson, Eric L., additional, Matzat, Stephen J., additional, Mayahi, Reza, additional, Mayes, Maureen Davidica, additional, McAlindon, Timothy, additional, McBain, Hayley, additional, McCarberg, Bill, additional, McCarthy, Edward F., additional, McCarthy, Geraldine, additional, McDermott, Michael F., additional, McGonagle, Dennis, additional, McLean, Lachy, additional, Merkel, Peter A., additional, Mikdashi, Jamal A., additional, Miller, Frederick W., additional, Miller, Paul D., additional, Minden, Kirsten, additional, Monach, Paul A., additional, Mulligan, Kathleen, additional, Namur, Gauthier, additional, Naredo, Esperanza, additional, Naylor, Kim E., additional, Nelson, Amanda E., additional, Newman, Stanton P., additional, Nordal, Ellen, additional, Nöth, Ulrich, additional, Ntatsaki, Eleana, additional, O'Shea, John J., additional, Oddis, Chester V., additional, Olivé, Alejandro, additional, Omair, Mohammed A., additional, Ombrello, Michael J., additional, Omisade, Antonina, additional, Ong, Voon H., additional, Önnerfjord, Patrik, additional, Orcel, Philippe, additional, Ospelt, Caroline, additional, Ozen, Seza, additional, Paget, Stephen A., additional, Patel, Dipak R., additional, Patrono, Carlo, additional, Pelletier, Jean-Pierre, additional, Pereira, Rosa Maria Rodrigues, additional, Pilkington, Clarissa A., additional, Pillinger, Michael H., additional, Pineda, Carlos, additional, Plenge, Robert M., additional, Price, Andrew, additional, Pricop, Luminita, additional, Rackwitz, Lars, additional, Ravelli, Angelo, additional, Redmond, Anthony C., additional, Reeves, Westley H., additional, Remmers, Elaine F., additional, Requena, Luis, additional, Ribbens, Clio, additional, Richardson, Bruce C., additional, Riera Alonso, Elena, additional, Riley, Graham, additional, Ritchlin, Christopher, additional, Ritter, Susan Y., additional, Rosas, Ivan O., additional, Rowan, Drew D., additional, Rudwaleit, Martin, additional, Rull, Marina, additional, Rygg, Marite, additional, Saag, Kenneth G., additional, Salmon, Jane E., additional, Salter, Donald M., additional, Salzberg, Daniel J., additional, Sambrook, Philip N., additional, Saxne, Tore, additional, Schaible, Hans-Georg, additional, Scher, Jose U., additional, Schett, Georg, additional, Schmitz, Nicole, additional, Schreiber, Benjamin, additional, Schumacher, H. Ralph, additional, Schwartz, Daniella Muallem, additional, Scott, David G.I., additional, Seton, Margaret, additional, Shapiro, Lauren M., additional, Sharby, Nancy, additional, Siegel, Jeffrey, additional, Siegel, Richard M., additional, Sieper, Joachim, additional, Silver, Richard M., additional, Silverberg, Shonni J., additional, Simard, Julia F., additional, Simmons, Barry P., additional, Simms, Robert W., additional, Singer, Nora G., additional, Smith, Malcolm D., additional, Smith, Stacy E., additional, Smolen, Josef S., additional, Spector, Tim D., additional, Steen, Virginia D., additional, Steere, Allen C., additional, Steiner, Günter, additional, Steinert, Andre F., additional, Stojan, George, additional, Stone, John H., additional, Strand, Vibeke, additional, Straub, Rainer H., additional, Streeten, Elizabeth A., additional, Superti-Furga, Giulio, additional, Symmons, Deborah P.M., additional, Szekanecz, Zoltan, additional, Tak, Paul P., additional, Tavoni, Antonio, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Thomas, Sarah S., additional, Thorne, Jennifer E., additional, Tobias, Jonathan H., additional, Tremoulet, Adriana H., additional, Tsokos, George C., additional, Tuan, Rocky S., additional, Turesson, Carl, additional, Unizony, Sebastian H., additional, Valdes, Ana M., additional, van den Berg, Wim B., additional, van der Heijde, Désirée, additional, van Vollenhoven, Ronald Frits, additional, Varga, John, additional, Vassilopoulos, Dimitrios, additional, Vital, Edward M., additional, Walker-Bone, Karen, additional, Wallace, Daniel J., additional, Warburton, Gary, additional, Ward, Robert J., additional, Watts, Richard, additional, Wechalekar, Mihir D., additional, Wedderburn, Lucy R., additional, Weinblatt, Michael E., additional, Weir, Matthew R., additional, Wenham, Claire Y.J., additional, West, Sterling G., additional, Weyand, Cornelia M., additional, White, Kenneth E., additional, Winthrop, Kevin L., additional, Wong, John B., additional, Woolf, Anthony D., additional, Worthington, Jane, additional, Xu, Huji, additional, Yazici, Hasan, additional, Young, D.A., additional, Yurdakul, Sebahattin, additional, Zhang, Yuqing, additional, and Zhuang, Haoyang, additional

Published
2015
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125. List of Contributors

Author

Agmon-Levin, Nancy, primary, Ahmed, S. Sohail, additional, Ali, Youssif M., additional, Aringer, Martin, additional, Bach, Jean-François, additional, Barker, Jennifer, additional, Barker, Robert N., additional, Baxter, Alan G., additional, Betterle, Corrado, additional, Birlea, Stanca A., additional, Björkström, Niklas K., additional, Blair, Paul A., additional, Bobik, Alex, additional, Borazan, Nabeel H., additional, Bosch, Xavier, additional, Brodsky, Robert A., additional, Bryceson, Yenan T., additional, Burkett, Patrick R., additional, Bussel, James B., additional, Butzkueven, Helmut, additional, Caricchio, Roberto, additional, Casciola-Rosen, Livia, additional, Caturegli, Patrizio, additional, Chatenoud, Lucienne, additional, Cohen, Philip L., additional, Coppieters, Ken, additional, Crome, Sarah Q., additional, Crystal, Ronald G., additional, Culton, Donna A., additional, Dalal, Monica D., additional, David, Chella S., additional, Davidson, Anne, additional, Delli, Ahmed J., additional, Delves, Peter J., additional, Denmark, Vera Kandror, additional, Diamond, Betty, additional, Diaz, Luis A., additional, Eaton, John E., additional, Eisenbarth, George S., additional, Falk, Ronald J., additional, Field, Judith, additional, Fleisher, Thomas A., additional, Fragoulis, George E., additional, Fritzler, Marvin J., additional, Furst, Daniel E., additional, Gallucci, Stefania, additional, Gelbman, Brian, additional, Eric Gershwin, M., additional, Getts, Daniel R., additional, Getts, Meghann Teague, additional, Gianani, Roberto, additional, Gleeson, Paul A., additional, Goding, James W., additional, Gordon, Siamon, additional, Goronzy, Jörg J., additional, Greer, Judith M., additional, Gruson, Berengere, additional, Guilherme, L., additional, Gutenberg, Angelika, additional, Hafler, David A., additional, Hahn, Bevra H., additional, Hamano, Hideaki, additional, Hamilton, Sara R., additional, Harrison, Leonard C., additional, Hernandez, Amanda L., additional, Husebye, Eystein, additional, Charles Jennette, J., additional, Jones, Richard J., additional, Jordan, Margaret A., additional, Kalil, J., additional, Königs, Christoph, additional, Kawa, Shigeyuki, additional, Kaya, Ziya, additional, King, Jennifer K., additional, King, Nicholas J.C., additional, Kiyosawa, Kendo, additional, Kronenberg, Mitchell, additional, Kuchroo, Vijay K., additional, Kyaw, Tin, additional, Lünemann, Jan, additional, Lahita, Robert G., additional, Lalezari, Parviz, additional, Lambert, Paul-Henri, additional, Lancaster, Eric, additional, Laurence, Arian, additional, Lee, Youjin, additional, Lenardo, Michael, additional, Lernmark, Åke, additional, Levinson, Arnold I., additional, Lindor, Keith D., additional, Liu, Zhi, additional, Ljunggren, Hans-Gustaf, additional, Lunardi, Claudio, additional, Lundin, Knut E.A., additional, Lunn, Michael P.T., additional, Lupi, Isabella, additional, Lustig, Livia, additional, Münz, Christian, additional, Mackay, Charles R., additional, Mackay, Ian R., additional, Malattia, Clara, additional, Mangalam, Ashutosh, additional, Martini, Alberto, additional, Mauri, Claudia, additional, Mavragani, Clio P., additional, Mayer, Lloyd, additional, McCombe, Pamela A., additional, Melchers, Fritz, additional, Mieli-Vergani, Giorgina, additional, Miller, Frederick W., additional, Miller, Stephen D., additional, Mizui, Masayuki, additional, Mjösberg, Jenny, additional, Moutsopoulos, Haralampos M., additional, Norris, David A., additional, Nussenblatt, Robert B., additional, O’Connor, Kevin C., additional, Ohashi, Pamela S., additional, O’Keeffe, Meredith, additional, Oliveira, Joao Bosco, additional, Oppenheim, Joost J., additional, Perez-Arroyo, Alicia, additional, Peters, Anneli, additional, Peterson, Pärt, additional, Plüddemann, Annette, additional, Posner, Jerome B., additional, Preston, Gloria A., additional, Puccetti, Antonio, additional, Radford, Kristen, additional, Ramos-Casals, Manuel, additional, Rao, V. Koneti, additional, Rauschkolb, Paula K., additional, Reddy, Venkat, additional, Redlich, Kurt, additional, Rival, Claudia, additional, Rose, Noel R., additional, Rosen, Antony, additional, Schrader, John W., additional, Schwaeble, Wilhelm J., additional, Selmi, Carlo, additional, Nida Sen, H., additional, Serota, Marc, additional, Sheikh, Kazim A., additional, Shoenfeld, Yehuda, additional, Shortman, Ken, additional, Sieper, Joachim, additional, Silverstein, Arthur M., additional, Sim, Robert B., additional, Simon, Anna, additional, Smolen, Josef S., additional, Sollid, Ludvig M., additional, Stoffels, Monique, additional, Su, Helen, additional, Syrbe, Uta, additional, Talwalkar, Jayant A., additional, Taneja, Veena, additional, Tincani, Angela, additional, Tipping, Peter, additional, Toh, Ban-Hock, additional, Tsokos, George C., additional, Tu, Eric, additional, Tung, Kenneth S.K., additional, van Driel, Ian R., additional, Vergani, Diego, additional, Vickers, Mark A., additional, Viegas, Stuart, additional, Vincent, Angela, additional, von Andrian, Ulrich H., additional, Herrath, Matthias von, additional, Weetman, Anthony P., additional, Wentworth, John M., additional, Weyand, Cornelia M., additional, Wingender, Gerhard, additional, Zanchetta, Renato, additional, and Zouali, Moncef, additional

Published
2014
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129. The STAT5-IRF4-BATF pathway drives heightened epigenetic remodeling in naïve CD4⁺ T cell responses of older adults

Author

Zhang, Huimin, Jadhav, Rohit R., Cao, Wenqiang, Goronzy, Isabel N., Jin, Jun, Greenleaf, William J., Weyand, Cornelia M., Goronzy, Jörg J., Zhang, Huimin, Jadhav, Rohit R., Cao, Wenqiang, Goronzy, Isabel N., Jin, Jun, Greenleaf, William J., Weyand, Cornelia M., and Goronzy, Jörg J.

Abstract

T cell aging is a complex process combining the emergence of cellular defects with activation of adaptive mechanisms. Generation of T cell memory is impaired, while a low-inflammatory state is induced, in part due to effector T cells. To determine whether age-associated changes in T cell fate decisions occur early after T cell activation, we profiled the longitudinal transcriptional and epigenetic landscape induced by TCR stimulation comparing naïve CD4⁺ T cells from young and older adults. In spite of attenuated TCR signaling, activation-induced remodeling of the epigenome increased with age, culminating in heightened BATF and BLIMP1 activity. Single cell studies, integrating ATAC-seq and RNA-seq data, identified increases in dysfunctional and in effector T cells and a decrease in BACH2-expressing memory cell precursors. STAT5 activation, in part due to a decline in HELIOS and aberrant IL-2 receptor expression, accounted for the induction of transcription factor networks favoring effector cell differentiation.

Published
2021

131. Decline in miR- 181 a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

Author

Li, Guangjin, Yu, Mingcan, Lee, Won-Woo, Tsang, Michae, Krishnan, Eswar, Weyand, Cornelia M., and Goronzy, Jorg J.

Subjects
T cells -- Receptors -- Physiological aspects -- Genetic aspects -- Research, Vaccination -- Physiological aspects -- Genetic aspects -- Research, Antigen receptors, T cell -- Physiological aspects -- Genetic aspects -- Research, Immune response -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health
Abstract

The ability of the human immune system to respond to vaccination declines with age. We identified an age-associated defect in T cell receptor (TCR)-induced extracellular signal-regulated kinase (ERK) phosphorylation in naive [CD4.sup.+] T cells, whereas other signals, such as θ chain-associated protein kinase 70 (ZAP70) and phospholipase C-γ1 phosphorylation, were not impaired. The defective ERK signaling was caused by the dual specific phosphatase 6 (DUSP6), whose protein expression increased with age due to a decline in repression by miR-181a. Reconstitution of miR-181a lowered DUSP6 expression in naive [CD4.sup.+] T cells in elderly individuals. DUSP6 repression using miR-181a or specific siRNA and DUSP6 inhibition by the allosteric inhibitor (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1 H-inden-1-one improved [CD4.sup.+] T cell responses, as seen by increased expression of activation markers, improved proliferation and supported preferential T helper type 1 cell differentiation. DUSP6 is a potential intervention target for restoring T cell responses in the elderly, which may augment the effectiveness of vaccination., With increasing age, the ability of the human immune system to protect against new antigenic challenges or to control chronic infections declines (1), (2). More than 90% of all influenza-related [...]

Published
2012
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137. Influence of age on functional memory T cell diversity

Author

Fang, Fengqin, primary, Cao, Wenqiang, additional, Zhu, Weikang, additional, Lam, Nora, additional, Li, Lingjie, additional, Gaddam, Sadhana, additional, Wang, Yong, additional, Kim, Chulwoo, additional, Lambert, Simon, additional, Zhang, Huimin, additional, Hu, Bin, additional, Farber, Donna L., additional, Weyand, Cornelia M., additional, and Goronzy, Jörg J., additional

Published
2021
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145. Preface to the fourth edition

Author

Rich, Robert R., primary, Fleisher, Thomas A., additional, Shearer, William T., additional, Schroeder, Harry W., additional, Frew, Anthony J., additional, and Weyand, Cornelia M., additional

Published
2013
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146. List of contributors

Author

Abraham, Roshini Sarah, primary, Albanesi, Cristina, additional, Alevizos, Ilias, additional, Anguita, Juan, additional, Anstead, Gregory M., additional, Aranow, Cynthia, additional, Austin, Howard A., additional, Babu, Subash, additional, Ballow, Mark C., additional, Balow, James E., additional, Barnidge, David R., additional, Belmont, John W., additional, Belz, Gabrielle T., additional, Ben-Yehuda, Dina, additional, Berek, Claudia, additional, Beukelman, Timothy, additional, Bieber, Thomas, additional, Bijlsma, Johannes W.J., additional, Bleesing, Jack J.H., additional, Blutt, Sarah E., additional, Bohle, Barbara, additional, Borzova, Elena, additional, Boyaka, Prosper N., additional, Knut, Brockow, additional, Bustamante, Jacinta, additional, Buttgereit, Frank, additional, Byrne, Mary, additional, Calder, Virginia L., additional, Carneiro-Sampaio, Magda, additional, Carotta, Sebastian, additional, Casanova, Jean-Laurent, additional, Cavacini, Lisa A., additional, Chan, Edwin S.L., additional, Chinen, Javier, additional, Chitnis, Tanuja, additional, Cho, Monique, additional, Christopher-Stine, Lisa, additional, Cope, Andrew P., additional, Corry, David B., additional, Cottrell, Tricia, additional, Coutinho, Antonio, additional, Craveiro, Marco, additional, Cron, Randy Q., additional, Cuellar-Rodriguez, Jennifer, additional, Dalakas, Marinos C., additional, de Barros, Stephanie C., additional, Devlin, Blythe H., additional, Diamond, Betty, additional, Dispenzieri, Angela, additional, Du Clos, Terry W., additional, Dupuis-Boisson, Stéphanie, additional, Eagar, Todd N., additional, Edhegard, Kim D., additional, Eisenbarth, George S., additional, Elmets, Craig A., additional, Erkan, Doruk, additional, Feinberg, Mark B., additional, Fikrig, Erol, additional, Fleisher, Thomas A., additional, Fontenot, Andrew P., additional, Franco, Luis M., additional, Freeman, Alexandra F., additional, Frew, Anthony J., additional, Friedman, Thea, additional, Fujihashi, Kohtaro, additional, Gadina, Massimo, additional, Galli, Stephen J., additional, Gaspar, H. Bobby, additional, Gatt, Moshe E., additional, Gershwin, M. Eric, additional, Ghoreschi, Kamran, additional, Gillespie, Susan L., additional, Goronzy, Jörg J., additional, Grattan, Clive E.H., additional, Greenspan, Neil S., additional, Grunebaum, Eyal, additional, Haeberli, Gabrielle, additional, Hall, Russell P., additional, Hamilton, Robert G., additional, Harriman, Gregory R., additional, Hasni, Sarfaraz A., additional, Helbling, Arthur, additional, Hingorani, Melanie, additional, Holland, Steven M., additional, Hruz, Petr L., additional, Illei, Gabor, additional, Imboden, John B., additional, Izraeli, Shai, additional, Jaffe, Elaine S., additional, Jagobi, Caroline, additional, Jalkanen, Sirpa, additional, Jetanalin, Pim, additional, Jouanguy, Emmanuelle, additional, June, Carl H., additional, Kallies, Axel, additional, Kaufmann, Stefan H.E., additional, Kavanaugh, Arthur, additional, Khan, Sabiha, additional, Kheradmand, Farrah, additional, Khoury, Samia J., additional, Koretzky, Gary A., additional, Korngold, Robert, additional, Kovalszki, Anna, additional, Kuhns, Douglas B., additional, Kyle, Robert A., additional, Lanza, Ian R., additional, Laurence, Arian, additional, Lee, Susan J., additional, Lenardo, Michael J., additional, Levinson, Arnold I., additional, Levy, Ofer, additional, Lewis, David B., additional, Lewis, Dorothy E., additional, Lightman, Sue L., additional, Lockshin, Michael D., additional, Lotze, Michael T., additional, Luong, Amber, additional, Mackay, Meggan, additional, Malo, Jean-Luc, additional, Maltzman, Jonathan S., additional, Mannon, Peter J., additional, Manns, Michael P., additional, Markert, Mary Louise, additional, McCarthy, Elizabeth A., additional, McDonald, Douglas R., additional, McGhee, Jerry R., additional, Melby, Peter C., additional, Metcalfe, Dean D., additional, Metz, Martin, additional, Miller, Stephen D., additional, Mitchell, Anna L., additional, Mittal, Shruti, additional, Miyara, Makoto, additional, Mold, Carolyn, additional, Moller, David R., additional, Mueller, Scott N., additional, Müller, Ulrich R., additional, Murphy, Philip M., additional, Noel, Pierre, additional, Notarangelo, Luigi, additional, Nutman, Thomas B., additional, Nutt, Stephen L., additional, Oliveira, João B., additional, Olson, Chris M., additional, O'Shea, John J., additional, Pai, Sung-Yun, additional, Pandit, Lavannya, additional, Paul, Mary E., additional, Pearce, Simon H.S., additional, Peterson, Erik J., additional, Picard, Capucine, additional, Pichler, Werner J., additional, Pittaluga, Stefania, additional, Puel, Anne, additional, Radbruch, Andreas, additional, Reece, Stephen T., additional, Reveille, John D., additional, Rich, Robert R., additional, Rivat, Christine, additional, Robinson, Bruce W.S., additional, Rodgers, John R., additional, Roifman, Chaim M., additional, Rosen, Antony, additional, Rosenbaum, James T., additional, Rouse, Barry T., additional, Rowley, Scott D., additional, Sakaguchi, Shimon, additional, Salmi, Marko, additional, Schroeder, Harry W., additional, Seibel, Markus J.H., additional, Selmi, Carlo, additional, Shafer, William M., additional, Shah, Prediman K., additional, Shankar, Sushma, additional, Shaw, Alan R., additional, Shearer, William T., additional, Sheikh, Javed, additional, Siegel, Richard, additional, Simon, Anna, additional, Simonian, Philip L., additional, Smith, Gideon P., additional, Smith, Justine R., additional, Snow, Andrew L., additional, Stephens, David S., additional, Stone, John H., additional, Straumann, Alex, additional, Su, Helen C., additional, Swainson, Louise, additional, Szymanska-Mroczek, Ewa, additional, Taylor, Naomi, additional, Thrasher, Adrian J., additional, Timares, Laura, additional, Torres, Raul M., additional, Uzel, Gülbŭ, additional, van der Meer, Jos W.M., additional, van der Hilst, Jeroen C.H., additional, Varga, John, additional, Waldman, Meryl, additional, Weiser, Peter, additional, Weller, Peter F., additional, Weyand, Cornelia M., additional, Whiteside, Theresa L., additional, Wigley, Fredrick M., additional, Winchester, Robert J., additional, Wing, Kajsa, additional, Wood, Kathryn, additional, Xu, Hui, additional, Zhang, Shen-Ying, additional, and Zimmermann, Valérie S., additional

Published
2013
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